Updated on 2024/12/24

Information

 

写真a

 
KITAMURA YOSHIYUKI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926411151
Profile
1) Education To students: teaching the fundamentals of nuclear medicine examination, method and features and findings of examination images To the resident doctor: teaching implementation and diagnosis of nuclear medical examination, understanding treatment methods in RI internal therapy, specific treatment and the way to explanation to patients / families. To the medical staff: instructed on basic knowledge of nuclear medicine examination and RI internal medicine therapy, and educates knowledge on examination, treatment, and disease. 2) Medical treatment I engage in nuclear medicine diagnosis and treatment at Kyushu University Hospital. - diagnosis, explanation of results about examination - 131 I Iodine treatment for differentiated thyroid cancer and hyperthyroidism - RI-labeled CD20 antibody therapy for low-grade malignant lymphoma - strontium 89 treatment for pain of multiple bone metastases - Ra-223 treatment for castration-resistant prostate cancer bone metastasis 3) Research I am conducting research on the examination of bone tumors (mainly bone metastasis of the prostate cancer) using 18F-NaF PET.
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Degree

  • Doctor of medical science, Master of infomation technology

Research History

  • 原三信病院(初期研修医)、独立行政法人国立病院機構 九州がんセンター(レジデント)、恩賜財団 済生会 八幡総合病院(医員)、日本赤十字山口綜合病院(医員)、独立行政法人地方病院機構 福岡市民病院(医員)

    原三信病院(初期研修医)、独立行政法人国立病院機構 九州がんセンター(レジデント)、恩賜財団 済生会 八幡総合病院(医員)、日本赤十字山口綜合病院(医員)、独立行政法人地方病院機構 福岡市民病院(医員)

Research Interests・Research Keywords

  • Research theme:A new diagnostic method using FDG-PET/CT for infections associated with left ventricular assist device

    Keyword:FDG-PET/CT, LVAD(left ventricular assist device), LVAD infection

    Research period: 2023.1 - 2025.6

  • Research theme:Usefulness of FDG-PET/CT for diagnosis of myocardial rejection after heart transplantation

    Keyword:FDG-PET/CT, myocardial rejection, heart transplantation

    Research period: 2022.1 - 2026.6

  • Research theme:Semi-quantitative Analysis of I-123 Metaiodobenzylguanidine (MIBG) SPECT/CT 

    Keyword:I-123 Metaiodobenzylguanidine (MIBG), SPECT/CT, Semi-quantitative Analysis, Neuroblastoma, Pheochromocytoma

    Research period: 2019.4 - 2022.5

  • Research theme:Bone SPECT/CT quantitative evaluation using statistical analysis method

    Keyword:SPECT, bone disease, quantitative evaluation, statistical analysis method

    Research period: 2019.4 - 2022.3

  • Research theme:Usefulness of 18F-NaF PET/CT for bone metastasis

    Keyword:18F-NaF for bone metastasis

    Research period: 2017.2 - 2020.4

Papers

  • Usefulness of semi-quantitative analysis in 123I metaiodobenzylguanidine SPECT/CT for the differentiation of pheochromocytoma and cortical adenoma Reviewed International journal

    Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Masayuki Sasaki, Akihiro Nishie, Kousei Ishigami

    Annals of Nuclear Medicine   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • I-123 metaiodobenzylguanidine (MIBG) uptake predicts early relapse of neuroblastoma using semi-quantitative SPECT/CT analysis Reviewed International journal

    Kitamura Yoshiyuki, Baba Shingo, Isoda Takuro, Maruoka Yasuhiro, Sasaki Masayuki, Kamitani Takeshi, Koga Yuhki, Kawakubo Naonori, Matsuura Toshiharu, Ishigami Kousei

    ANNALS OF NUCLEAR MEDICINE   35 ( 5 )   549 - 556   2021.5

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    DOI: 10.1007/s12149-021-01595-7

  • <SUP>18</SUP>F-Fluorodeoxyglucose Positron Emission Tomography Can be a Novel Diagnostic Tool for Detecting Acute Cellular Rejection Following Heart Transplantation

    Yoshitake, T; Fujino, T; Yamamoto, S; Hashimoto, T; Suenaga, T; Shinohara, K; Matsushima, S; Kitamura, Y; Komman, H; Toyosawa, M; Ide, T; Shiose, A; Kinugawa, S

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   43 ( 4 )   S206 - S206   2024.4   ISSN:1053-2498 eISSN:1557-3117

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  • Dynamic chest radiography for pulmonary vascular diseases: clinical applications and correlation with other imaging modalities

    Yamasaki Yuzo, Kamitani Takeshi, Sagiyama Koji, Hino Takuya, Kisanuki Megumi, Tabata Kosuke, Isoda Takuro, Kitamura Yoshiyuki, Abe Kohtaro, Hosokawa Kazuya, Toyomura Daisuke, Moriyama Shohei, Kawakubo Masateru, Yabuuchi Hidetake, Ishigami Kousei

    Japanese Journal of Radiology   42 ( 2 )   126 - 144   2023.8   ISSN:18671071 eISSN:1867108X

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    Dynamic chest radiography (DCR) is a novel functional radiographic imaging technique that can be used to visualize pulmonary perfusion without using contrast media. Although it has many advantages and clinical utility, most radiologists are unfamiliar with this technique because of its novelty. This review aims to (1) explain the basic principles of lung perfusion assessment using DCR, (2) discuss the advantages of DCR over other imaging modalities, and (3) review multiple specific clinical applications of DCR for pulmonary vascular diseases and compare them with other imaging modalities.

    DOI: 10.1007/s11604-023-01483-2

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  • Impacts of Clinical and Imaging Factors on the Outcome of Radioiodine Therapy for the Patients with Bone Metastasis from Thyroid Cancer

    Isoda, T; Baba, S; Maruoka, Y; Kitamura, Y; Sasaki, M; Ishigami, K

    JOURNAL OF NUCLEAR MEDICINE   64   2023.6   ISSN:0161-5505 eISSN:1535-5667

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  • Predicting value of 11C-methionine PET/CT in gliomas based on the 2021 WHO classification.

    Kitamura, Y; Baba, S; Isoda, T; Maruoka, Y; Togao, O; Kuga, D; Sasaki, M; Ishigami, K

    JOURNAL OF NUCLEAR MEDICINE   64   2023.6   ISSN:0161-5505 eISSN:1535-5667

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  • Efficacy of Dynamic Chest Radiography for Chronic Thromboembolic Pulmonary Hypertension

    Yamasaki, Y; Abe, K; Kamitani, T; Hosokawa, K; Hida, T; Sagiyama, K; Matsuura, Y; Baba, S; Isoda, T; Maruoka, Y; Kitamura, Y; Moriyama, S; Yoshikawa, H; Fukumoto, T; Yabuuchi, H; Ishigami, K

    RADIOLOGY   306 ( 3 )   e220908   2023.3   ISSN:0033-8419

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    Language:English   Publisher:Radiology  

    Background: While current guidelines require lung ventilation-perfusion (V/Q) scanning as the first step to diagnose chronic pulmonary embolism in pulmonary hypertension (PH), its use may be limited by low availability and/or exposure to ionizing radiation. Purpose: To compare the performance of dynamic chest radiography (DCR) and lung V/Q scanning for detection of chronic thromboembolic PH (CTEPH). Materials and Methods: Patients with PH who underwent DCR and V/Q scanning in the supine position from December 2019 to July 2021 were retrospectively screened. The diagnosis of CTEPH was confirmed with right heart catheterization and invasive pulmonary angiography. Observer tests were conducted to evaluate the diagnostic accuracy of DCR and V/Q scanning. The lungs were divided into six areas (upper, middle, and lower for both) in the anteroposterior image, and the number of lung areas with thromboembolic perfusion defects was scored. Diagnostic performance was compared between DCR and V/Q scanning using the area under the receiver operating characteristic curve. Agreement between the interpretation of DCR and that of V/Q scanning was assessed using the Cohen kappa coefficient and percent agreement. Results: A total of 50 patients with PH were analyzed: 29 with CTEPH (mean age, 64 years ± 15 [SD]; 19 women) and 21 without CTEPH (mean age, 61 years ± 22; 14 women). The sensitivity, specificity, and accuracy of DCR were 97%, 86%, and 92%, respectively, and those of V/Q scanning were 100%, 86%, and 94%, respectively. Areas under the receiver operating characteristic curve for DCR and V/Q scanning were 0.92 (95% CI: 0.79, 0.97) and 0.93 (95% CI: 0.78, 0.98). Agreement between the consensus interpretation of DCR and that of V/Q scanning was substantial (κ = 0.79 [95% CI: 0.61, 0.96], percent agreement = 0.9 [95% CI: 0.79, 0.95]). Conclusion: Dynamic chest radiography had similar efficacy to ventilation-perfusion scanning in the detection of chronic thromboembolic pulmonary hypertension.

    DOI: 10.1148/radiol.220908

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  • Utility of FDG PET at the Initial Radioiodine Therapy in Differentiated Thyroid Cancer Invited Reviewed International journal

    MIOKO MATSUO, SHINGO BABA, KAZUKI HASHIMOTO, TAKURO ISODA, YOSHIYUKI KITAMURA, RYUNOSUKE KOGO, RINA JIROMARU, TAKAHIRO HONGO, TOMOMI MANAKO, TAKASHI NAKAGAWA

    ANTICANCER RESEARCH   43 ( 1 )   183 - 190   2023.1   ISSN:0250-7005 eISSN:1791-7530

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    DOI: 10.21873/anticanres.16148

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  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[<SUP>18</SUP>F]-fluoro-2-deoxy-D-glucose positron-emission tomography

    Tabata, K; Nishie, A; Shimomura, Y; Isoda, T; Kitamura, Y; Nakata, K; Yamada, Y; Oda, Y; Ishigami, K; Baba, S

    CLINICAL RADIOLOGY   77 ( 6 )   436 - 442   2022.6   ISSN:0009-9260 eISSN:1365-229X

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    Language:English   Publisher:Clinical Radiology  

    AIM: To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-[18F]-fluoro-2-deoxy-D-glucose positron-emission tomography (F-18 FDG-PET). MATERIALS AND METHODS: Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis. RESULTS: The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively. CONCLUSIONS: SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.

    DOI: 10.1016/j.crad.2022.03.001

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  • Is the image quality of conventional chest radiography obtained from a two-layer flat panel detector affected by the internal structure of the detector?

    Takarabe, S; Kuramoto, T; Shibayama, Y; Yamasaki, Y; Kitamura, Y; Yoshikawa, H; Kato, T

    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS   95   176 - 181   2022.3   ISSN:1120-1797 eISSN:1724-191X

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    Purpose: Recently developed and commercialized dual-layer flat panel detectors (DL-FPDs) with two indirect scintillators are capable of acquiring dual-energy X-ray images. However, in clinical practice, they are utilized to perform conventional radiography using diagnostic X-rays with a wide energy spectrum. The two layers of the DL-FPD may affect the obtained image quality, even when only using one layer for conventional image acquisition, and these effects are yet to be substantiated. Therefore, in this study, we quantitatively evaluated the image quality of a conventional chest radiography using DL-FPD and visually verified the characteristics of the chest anthropomorphic phantom images. Methods: The physical characteristics of the system were evaluated using the pre-sampled modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE), for beam quality RQA 7 and RQA 9. In addition, the subjective visibility of the anthropomorphic chest phantom and simple objects images were compared with those of a conventional single-layer flat-panel detector (SL-FPD). Results: No significant differences were found in the MTF between the SL-FPD and DL-FPD images. In addition, a higher DQE was observed at some exposure doses and in the high spatial frequency regions wherein NNPSs were lower for DL-FPD than for SL-FPD. Furthermore, no significant differences were found in the subjective visibility of the chest phantoms in each system. Conclusions: We concluded that the image quality of the conventional radiography acquired with DL-FPD is comparable to or better than that of the SL-FPD.

    DOI: 10.1016/j.ejmp.2022.02.004

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  • 褐色細胞腫と副腎皮質腺腫の鑑別に、123IメタヨードベンジルグアニジンSPECT/CTによる半定量分析の有用性(Usefulness of semi-quantitative analysis in 123I metaiodobenzylguanidine SPECT/CT for the differentiation of pheochromocytoma and cortical adenoma)

    Kitamura Yoshiyuki, Baba Shingo, Isoda Takuro, Maruoka Yasuhiro, Sasaki Masayuki, Nishie Akihiro, Ishigami Kousei

    Annals of Nuclear Medicine   36 ( 1 )   95 - 102   2022.1   ISSN:0914-7187

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    2011年1月~2015年2月までの期間内に、当院で123I MIBG SPECT/CT検査を受けた、褐色細胞腫(PHEO)患者21例(男性10例、女性11例、年齢24~80歳)と、副腎皮質腺腫(CA)患者23例(男性15例、女性8例、年齢30~78歳)を対象に調査した。123Iメタヨードベンジルグアニジン(MIBG) SPECT/CT所見から、腫瘍と肝臓へ集積最大値の比(T/Lmax)、腫瘍と肝臓への集積平均値の比(T/Lmean)、腫瘍と骨格筋への集積最大値の比(T/Mmax)、腫瘍と骨格筋への集積平均値の比(T/Mmean)について、半定量的に解析した。その結果、ROC解析によるAUCでは、123I MIBGのプラナー画像の視覚スコアが0.833、SPECT画像の視覚スコアが0.813で、T/Lmaxが0.986、T/Lmeanが0.975、T/Mmaxが0.955、T/Mmeanが0.933であった。なかでも、T/MmaxのAUCでは、123I MIBGのプラナー画像の視覚スコアや、SPECT画像の視覚スコアに比べ、有意に高値が検出された。以上の解析結果から、PHEOとCAの鑑別に、123I MIBG SPECT/CTによる半定量分析が有用と判断された。

  • Usefulness of semi-quantitative analysis in <SUP>123</SUP>I metaiodobenzylguanidine SPECT/CT for the differentiation of pheochromocytoma and cortical adenoma

    Kitamura, Y; Baba, S; Isoda, T; Maruoka, Y; Sasaki, M; Nishie, A; Ishigami, K

    ANNALS OF NUCLEAR MEDICINE   36 ( 1 )   95 - 102   2022.1   ISSN:0914-7187 eISSN:1864-6433

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    Objective: 123I metaiodobenzylguanidine (MIBG) scintigraphy is a useful tool for the diagnosis of pheochromocytomas (PHEOs), but some PHEOs are difficult to differentiate from cortical adenoma (CA) or normal adrenal uptake by visual evaluation alone. A new semi-quantitative analysis using 123I MIBG SPECT/CT is thus expected. Herein, we introduce the tumor-to-liver count ratio (T/L) and the tumor-to-muscle count ratio (T/M). Methods: We examined the cases of 21 patients with PHEOs (10 males, 11 females; age 24–80, median 61 years) and 23 patients with CA (15 males and 8 females, age 30–78, median 58 years). The visual scoring based on 123I MIBG planar images (planar score) and SPECT images (SPECT score) was used as the conventional evaluation. Using 123I MIBG SPECT/CT findings, we calculated the semi-quantitative values of the count ratio using the maximum or mean count of the tumor and the liver or muscle as the reference organ (T/Lmax, T/Lmean, T/Mmax and T/Mmean). Each evaluation of the PHEOs and CAs was compared, and the diagnosing performance was evaluated based on an ROC analysis. Results: The area under curve (AUC) values were as follows: the planar score, 0.833; SPECT score, 0.813; T/Lmax, 0.986; T/Lmean, 0.975; T/Mmax, 0.955; and T/Mmean, 0.933. The AUC for T/Mmax was significantly higher than those of the planar score, and SPECT score by ROC analysis (p < 0.01 each). Conclusion: The semi-quantitative value of 123I MIBG SPECT/CT is more useful than the conventional visual evaluation for differentiating PHEOs from CAs.

    DOI: 10.1007/s12149-021-01690-9

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  • Diagnosis of Pulmonary Hypertension Using Dynamic Chest Radiography Reviewed International journal

    Yuzo Yamasaki, Takeshi Kamitani, Kohtaro Abe, Kazuya Hosokawa, Koji Sagiyama, Tomoyuki Hida, Yuko Matsuura, Yoshiyuki Kitamura, Yasuhiro Maruoka, Takuro Isoda, Shingo Baba, Hideki Yoshikawa, Taku Kuramoto, Hidetake Yabuuchi, Kousei Ishigami

    Am J Respir Crit Care Med   2021.12

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  • Diagnostic accuracy for the epileptogenic zone detection in focal epilepsy could be higher in FDG-PET/MRI than in FDG-PET/CT Reviewed International journal

    Kikuchi K, Togao O, Yamashita K, Momosaka D, Nakayama T, Kitamura Y, Kikuchi Y, Baba S, Sagiyama K, Ishimatsu K, Kamei R, Mukae N, Iihara K, Suzuki SO, Iwaki T, Hiwatashi A

    Eur Radiol   2021.5

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  • Impact of Metabolic Activity in Hepatocellular Carcinoma: Association With Immune Status and Vascular Formation Reviewed International journal

    Shinji Itoh, Tomoharu Yoshizumi, Yoshiyuki Kitamura, Kyohei Yugawa, Norifumi Iseda, Tomonari Shimagaki, Yoshihiro Nagao, Takeo Toshima, Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, Masaki Mori

    Hepatol Commun   2021.5

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  • Usefulness of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Infective Endocarditis in Patients With Adult Congenital Heart Disease Reviewed International journal

    Ayako Ishikita, Ichiro Sakamoto, Kenichiro Yamamura, Shintaro Umemoto, Hazumu Nagata, Yoshiyuki Kitamura, Yuzo Yamasaki, Hiromichi Sonoda, Hideki Tatewaki, Akira Shiose, Hiroyuki Tsutsui

    Circ J   2021.4

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  • A functional scoring system based on salivary gland scintigraphy for evaluating salivary gland dysfunction secondary to 131I therapy in patients with differentiated thyroid carcinoma Reviewed

    Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Horoshi Honda

    Journal of Clinical and Diagnostic Research   11 ( 8 )   TC23 - TC28   2017.8

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    DOI: 10.7860/JCDR/2017/27340.10431

  • Association between volumetric analysis of lung metastases on F-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography and short-term progression after i-131 therapy for differentiated thyroid carcinoma Reviewed

    Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda

    Indian Journal of Nuclear Medicine   32 ( 3 )   167 - 172   2017.7

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    DOI: 10.4103/ijnm.IJNM_43_17

  • Three-dimensional fractal analysis of 99m Tc-MAA SPECT images in chronic thromboembolic pulmonary hypertension for evaluation of response to balloon pulmonary angioplasty Association with pulmonary arterial pressure Reviewed

    Yasuhiro Maruoka, Michinobu Nagao, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Yuzo Yamazaki, Koichiro Abe, Masayuki Sasaki, Kotaro Abe, Hiroshi Honda

    Nuclear Medicine Communications   38 ( 6 )   480 - 486   2017.5

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    DOI: 10.1097/MNM.0000000000000673

  • Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System, BONENAVI, on Bone Scintigraphy Images Reviewed International journal

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Masayuki Sasaki, Masamitsu Hatakenaka, Hiroshi Honda

    Asia Oceania Journal of Nuclear Medicine and Biology   5 ( 1 )   49 - 55   2017.1

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    DOI: 10.22038/aojnmb.2016.7606

  • The Efficiency of Respiratory-gated 18F-FDG PET/CT in Lung Adenocarcinoma: Amplitude-gating Versus Phase-gating Methods Reviewed International journal

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Masayuki Sasaki, Masamitsu Hatakenaka, Hiroshi Honda

    Asia Oceania Journal of Nuclear Medicine and Biology   5 ( 1 )   30 - 36   2017.1

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    DOI: 10.22038/aojnmb.2016.7747

  • Metabolic Tumor Volume by (18)F-FDG PET/CT Can Predict the Clinical Outcome of Primary Malignant Spine/Spinal Tumors Reviewed

    Yoshihiro Matsumoto, Shingo Baba, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Jun-Ichi Fukushi, Kenichi Kawaguchi, Seiji Okada, Hirofumi Bekki, Takuro Isoda, Yoshiyuki Kitamura, Hiroshi Honda, Yasuharu Nakashima

    BioMed Research International   2017   8132676   2017

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    DOI: 10.1155/2017/8132676

  • Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme. Reviewed International journal

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazuhumi Kikuchi, Yoshiyuki Kitamura, Masahiro Mizoguchi, Koji Yoshimoto, Takuro Isoda, Shingo Baba, Koji Iihara, Toru Iwaki, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   44 ( 5 )   1256 - 1261   2016.11

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    DOI: 10.1002/jmri.25261

  • Impact of patient age on the iodine/FDG “flip-flop” phenomenon in lung metastasis from thyroid cancer Reviewed

    30 ( 8 )   518 - 524   2016.10

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    Objectives: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called “flip-flop” phenomenon. The aim of this study was to assess the relationship between patient age and the occurrence of the flip-flop phenomenon. Methods: Eighty-six patients who underwent radioiodine therapy for lung metastasis were studied retrospectively (age 17–73 years; median 60 years; males:females 22:64). We compared the clinical data and imaging findings (size and FDG uptake of lung nodules) between patients with (n = 44) and without (n = 42) iodine uptake in lung metastasis. Results: Significantly more young patients showed iodine accumulation in lung metastasis than old patients (p = 0.0025). Lung metastases with larger size or greater FDG uptake showed no iodine uptake more frequently with significant difference (p = 0.015 and <0.001, respectively). Among patients with FDG uptake in the lung metastasis, 57.1 % of young patients (<60 years) and 24.3 % of the old patients (≥60 years) showed iodine uptake (p = 0.0029). Conclusions: Higher patient age and lung nodules with large size or FDG accumulation are negative factors for iodine accumulation in lung metastases from thyroid cancer. In addition, our results show that young patients have a greater likelihood of iodine uptake even when FDG accumulates in lung metastasis, in contrast to old patients.

    DOI: 10.1007/s12149-016-1104-9

  • Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing Detection of ischemia for intermediate coronary stenosis Reviewed

    Michinobu Nagao, Yuzo Yamasaki, Takeshi Kamitani, Satoshi Kawanami, Koji Sagiyama, Torahiko Yamanouchi, Yamato Shimomiya, Tetsuya Matoba, Yasushi Mukai, Keita Odashiro, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Akihiro Nishie, Hiroshi Honda

    European Journal of Radiology   85 ( 5 )   996 - 1003   2016.5

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    DOI: 10.1016/j.ejrad.2016.02.027

  • Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy Reviewed

    Michinobu Nagao, Shingo Baba, Masato Yonezawa, Yuzo Yamasaki, Takeshi Kamitani, Takuro Isoda, Satoshi Kawanami, Yasuhiro Maruoka, Yoshiyuki Kitamura, Kotaro Abe, Taiki Higo, Kenji Sunagawa, Hiroshi Honda

    International Journal of Cardiovascular Imaging   31 ( 2 )   399 - 407   2015.2

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    DOI: 10.1007/s10554-014-0562-1

  • Inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen Case report and review of the literature Reviewed

    Yoshiyuki Kitamura, Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, yasuhiro ushijima, nobuhiro fujita, Koichirou Morita, Shingo Baba, Yuichiro Kubo, Ken Shirabe, Hiroshi Honda

    Magnetic Resonance in Medical Sciences   14 ( 4 )   347 - 354   2015.1

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    DOI: 10.2463/mrms.2014-0052

  • Role of FDG-PET for the treatment strategy of malignant lymphoma Reviewed

    Shingo Baba, Takuro Isoda, Y. Maruoka, Yoshiyuki Kitamura, Hiroshi Honda, Masayuki Sasaki

    Japanese Journal of Clinical Radiology   59 ( 10 )   1292 - 1301   2014.10

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  • Diagnostic and prognostic value of pretreatment SUV in 18F-FDG/ PET in breast cancer Comparison with apparent diffusion coefficient from diffusion-weighted MR imaging Reviewed

    Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Tsuyoshi Yoshida, Hiroshi Honda

    Journal of Nuclear Medicine   55 ( 5 )   736 - 742   2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2967/jnumed.113.129395

  • Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations Reviewed

    Yuji Tsutsui, Daisuke Kidera, Takafumi Taniguchi, Go Akamatsu, Isao Komiya, Yoshiyuki Umezu, Yoshiyuki Kitamura, Shingo Baba, Masayuki Sasaki

    Annals of Nuclear Medicine   28 ( 8 )   770 - 779   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12149-014-0870-5

  • Nabothian Cyst a predominant cause of false-positive iodine uptake in Uterus Comparison of SPECT/CT and Pelvic MRI Reviewed

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Akihiro Nishie, Masayuki Sasaki, Hiroshi Honda

    Clinical Nuclear Medicine   39 ( 8 )   680 - 684   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/RLU.0000000000000504

  • Usefulness of partial volume effect-corrected F-18 FDG PET/CT for predicting I-131 accumulation in the metastatic lymph nodes of patients with thyroid carcinoma Reviewed

    Yasuhiro Maruoka, Koichiro Abe, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Noriko Mizoguchi, Go Akamatsu, Masayuki Sasaki, Hiroshi Honda

    Annals of Nuclear Medicine   27 ( 10 )   873 - 879   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12149-013-0767-8

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Presentations

  • Usefulness of FDG-PET/CT for diagnosis of myocardial rejection after heart transplantation International conference

    Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Takeo Fujino, Masayuki Sasaki, Kosei Ishigami

    SNMMI 2022 Annual Meeting  2022.6 

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    Event date: 2023.6

    Language:English  

    Country:United States  

  • Predicting value of 11C-methionine PET/CT in gliomas based on the 2021 WHO classification International conference

    Yoshiyuki Kitamura, Takuro Isoda, Yasuhiro Maruoka, Osamu Togao, Shingo Baba, Kosei Ishigami

    SNM annual meeting 2023  2023.6 

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    Event date: 2023.6

    Language:English  

    Country:United States  

  • 神経内分泌腫瘍PRRTにおけるソマトスタチン受容体シンチグラフィ定量測定の有用性

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 佐々木 雅之, 石神 康生

    第58回 日本核医学会 九州地方会  2023.2 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米市, 福岡   Country:Japan  

  • 心臓移植後左室心筋FDG集積の検討

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 佐々木 雅之, 藤野 剛雄, 石神 康生

    第57回 日本核医学会九州地方会  2022.2 

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    Event date: 2022.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 大腿骨頭壊死症に対する統計解析手法を用いた骨SPECT/CT定量評価の有用性

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 神谷 武志, 佐々木 雅之, 本村 悟朗, 石神 康生

    第60回日本核医学学術総会  2020.11 

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    Event date: 2020.11

    Language:Japanese  

    Venue:神戸市、兵庫   Country:Japan  

  • 体動補正機能を用いたFDG-PET/CTによる肺病変撮像の有用性:息止め撮像との比較

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 眞鍋 裕介, 神谷 武志, 西江 昭弘, 佐々木 雅之

    第56回 日本核医学会九州地方会  2020.2 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀市   Country:Japan  

  • Predicting Efficacy of Radium-223 Dichrolide (223RaCl2) therapy in Bone-metastatic Castration-resistant Prostate Cancer Using F-18 Sodium Fluoride (18F-NaF) PET/CT International conference

    Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Ryo Somehara, Masayuki Sasaki2, Hiroshi Honda1

    SNMMI 2019 Annual Meeting  2019.6 

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    Event date: 2020.6

    Language:English  

    Country:United States  

  • 大腿骨頭壊死症における統計解析手法を用いたSPECT/CTの有用性

    北村 宜之,馬場 眞吾,磯田 拓郎,丸岡 保博,神谷 武志,佐々木 雅之,本村 悟朗,石神 康生

    第59回日本核医学会学術総会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:松山市、愛媛   Country:Japan  

  • 核医学のアイデアを症例検討に活かす~核医学が診断の決め手となった症例の施設対抗Q&A~ Invited

    北村 宜之

    第59回日本核医学会学術総会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:松山市、愛媛   Country:Japan  

  • 去勢抵抗性前立癌骨転移に対する223RaCl2治療~基礎知識と当院での治療の実際~ Invited

    北村 宜之

    第1回 日本核医学会 九州・沖縄支部会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市、福岡   Country:Japan  

  • 去勢抵抗性前立腺癌骨転移患者に対するRa-223 RaClに治療におけるF-18 NaF PET/CTを用いた治療効果予測

    北村 宜之,馬場 眞吾,磯田 拓郎,染原 涼,本田 浩,猪口 淳一,佐々木 雅之

    第54回 日本核医学会九州地方会  2019.2 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

    【目的】去勢抵抗性前立腺癌骨転移に対する223RaCl2内用療法の客観的な治療効果評価には血中ALPが用いられる。骨トレーサーであるF-18 Sodium Fluoride(NaF)を用いたPET/CT(以下18F-NaF PET/CT)では半定量値の測定が可能である。本研究では18F-NaF PET/CTの半定量値とRa-223 RaCl治療における血中ALPとの関係を調べ、治療効果予測の有用性を検証した。
    【方法】2017年3月から2018年10月までにRa-223 RaCl内用療法を施行され、治療開始時に18F-NaF PET/CTを施行し、治療開始時および治療終了後に血中ALPを測定した男性6名(年齢 65-77歳、中央値 68歳)。18F-NaF PET/CT半定量値としてSUVmax、SUVmax≧10となる領域を病変と仮定したMTVおよびTLGを測定し、ALPおよび治療前後のALP比(ALP%)との相関をそれぞれ調べた。
    【結果】ALPとSUVmax、MTV、TLGの間には弱い正の相関がみられた。ALP%とSUVmax、MTV、TLGの間には負の相関が見られ、特にALP%とSUVmaxで強い相関がみられた(R2=0.84)。
    【結語】18F-NaF PET/CTのSUVmaxが高いほどALPの減少率が高く、去勢抵抗性前立腺癌骨転移に対する223RaCl2内用療法の治療効果予測に有用である可能性が示唆された。

  • Assessment of the effect of Urinary excretion rate of 18F-Sodium fluoride on the SUV of NaF PET/CT.

    Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Ryo Somehara, Keiichiro Tahara, Akifumi Yamada, Masayuki Sasaki, Hiroshi Honda

    2018.4 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • F-18 NaF PET/CTにおける加齢による正常骨集積変化の検証

    北村 宜之,馬場 眞吾,磯田 拓郎,染原 涼,田原 圭一郎,本田 浩,佐々木 雅之

    第185回 日本医学放射線学会九州地方会  2017.6 

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    Event date: 2018.6

    Language:Japanese  

    Venue:福岡県久留米市 久留米シティプラザ   Country:Japan  

    【背景】F-18 NaF(Sodium Fluoride)を用いたPET/CT(以下NaF PET)は主に骨代謝亢進を反映するトレーサーであり、半定量値(SUV:Standardarized uptake value)の計測が可能である。しかし骨の部位によってSUVが異なることが知られている。特に脊椎、骨盤骨など赤色骨髄が分布する骨で集積程度が強く、これらの骨は加齢に伴い集積が変化する可能性がある。
    【目的】若年と老年それぞれの成人男性におけるNaF PETの集積を比較し、骨の部位ごとの半定量値と年齢との相関を検証する。
    【方法】4名の正常成人男性および2名の前立腺癌患者に対してNaF PETを施行した。60歳以下を若年群、60歳以上を老年群として、投与60分後に撮像を行い、骨の各部位でSUVmaxおよびSUVmeanを測定し、それぞれの部位について2群間で比較を行った。
    【結果】測定した骨のうち、脊椎や骨盤骨では若年群に比べ老年群で集積が低かった。頭蓋骨、大腿骨、上腕骨では若年群と老年群に有意な差は認めなかった。腰椎では年齢とSUVmaxおよびSUVmeanで有意な相関を認め(p=0.01)、高齢者ほど集積が低かった。
    【結論】NaF PETにおいて、特に赤色骨髄を有しうる骨では病変の半定量解析の際に年齢を考慮する必要がある。

  • 骨肉腫の術前化学療法の治療効果予測におけるFDG-PET/CTの各種指標の有用性の検討

    田原 圭一郎, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 染原 涼, 本田 浩

    第56回日本核医学会学術総会  2017.10 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川県横浜市 パシフィコ横浜   Country:Japan  

  • 神経内分泌腫瘍の診断におけるソマトスタチン受容体シンチの初期経験

    染原 涼, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 田原 圭一郎, 西江 昭弘, 浅山 良樹, 石神 康生, 佐々木 雅之, 本田 浩

    第52回 日本核医学会九州地方会  2017.2 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:那覇市   Country:Japan  

  • Usefulness of volume-based analysis of FDG-PET for prognosis prediction of malignant musculoskeletal tumor. International conference

    2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Comparison of multiple parameters of FDG PET/CT in the prognosis prediction in the patients with lymphoma treated with allogeneic transplantation International conference

    2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT International conference

    2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 18FDG-PET/CTにおけるmetabolic tumor volumeと分化型甲状腺癌肺転移症例における放射性ヨウ素治療後反応性との関連

    丸岡 保博, 馬場 眞吾, 磯田 拓郎, 北村 宜之, 田原 圭一郎, 佐々木 雅之, 本田 浩

    第183回日本医学放射線学会九州地方会  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎市   Country:Japan  

  • Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer International conference

    63th Annual Meeting, Society of Nuclear Medicine  2016.6 

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    Event date: 2016.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT International conference

    63th Annual Meeting, Society of Nuclear Medicine  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Relationship of the I-123 Metaiodobenzylguanidine (MIBG) Uptake and Early Relapse of Neuroblastoma Using Semi-quantitative Analysis of SPECT/CT International conference

    63th Annual Meeting, Society of Nuclear Medicine  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Usefulness of Semi-quantitative Analysis in I-123 Metaiodobenzylguanidine Scintigraphy for Differentiation of Pheochromocytoma and Cortical Adenoma International conference

    2016.4 

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 甲状腺癌に対する放射性ヨウ素内用療法において子宮筋腫に強いヨウ素集積を認めた1例

    井上 紗也香, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 牛島 泰宏, 石神 康生, 佐々木 雅之

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • 機械学習を用いた悪性リンパ腫のFDG-PET画像のMTV測定の有用性

    馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 佐々木 雅之, 石神 康生

    核医学  2022.8  (一社)日本核医学会

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  • 心臓移植後左室心筋FDG集積の検討

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 石神 康生, 藤野 剛雄, 佐々木 雅之

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • 前立腺のFDG集積 排尿前撮像による尿中FDG逆流の証明

    磯田 拓郎, 馬場 眞吾, 丸岡 保博, 北村 宜之, 佐々木 雅之, 石神 康生

    核医学  2022.8  (一社)日本核医学会

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  • 体動補正機能を用いたFDG-PET/CT肺病変撮像の有用性 息止め撮像との比較

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 眞鍋 裕介, 神谷 武志, 西江 昭弘, 佐々木 雅之

    Japanese Journal of Radiology  2022.2  (公社)日本医学放射線学会

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  • FDG-PETにて高集積を呈したEpithelioid angiomyolipoma(eAML)の1例

    大島 健史, 馬場 眞吾, 北村 宜之, 丸岡 保博, 磯田 拓郎, 石神 康生, 今田 憲二郎, 孝橋 賢一

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • FDG-PET/CTが診断に寄与したTAFRO症候群の1例

    中村 勇星, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 石神 康生, 陳之内 文昭, 山元 英崇

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • Deep Learningを用いた再構成法に影響する患者要因の検討

    磯田 拓郎, 北村 宜之, 楠 正興, 三道 幹大, 吉留 郷志, 馬場 眞吾, 石神 康生

    核医学  2023  (一社)日本核医学会

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  • 99mTc-macroaggregated albumin(MAA)を用いた肺血流シンチグラフィにて椎体に高集積を示した上大静脈症候群の1例

    磯田 拓郎, 馬場 眞吾, 丸岡 保博, 北村 宜之, 眞鍋 裕介, 西江 昭弘, 佐々木 雅之

    Japanese Journal of Radiology  2022.2  (公社)日本医学放射線学会

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  • 3D U-netを用いた全身FDG-PET/CTの高精度腫瘍セグメンテーションの自動化(Automated high accuracy tumor segmentation of whole-body FDG-PET/CT using 3D U-net)

    Baba Shingo, Isoda Takuro, Kitamura Yoshiyuki, Kusunoki Masaoki, Sandou Motohiro, Ishii Hideaki, Yamane Toshimizu, Ueno Shunya, Ishigami Kosei

    核医学  2023  (一社)日本核医学会

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  • 111Inソマトスタチン受容体シンチグラフィーにおいて全身像の収集時間が内部臓器被ばく線量推定に及ぼす影響

    山下 泰生, 北村 宜之, 吉留 聡志, 粟元 伸一, 小林 幸次, 寳部 真也, 馬場 眞吾

    日本放射線技術学会総会学術大会予稿集  2022.3  (公社)日本放射線技術学会

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  • 111Inを用いたソマトスタチン受容体シンチグラフィーにおける撮影速度と撮影タイミングが線量に与える影響(The influence of acquisition speed and timing on the dosimetry in 111In somatostatin receptor scintigraphy)

    Yamashita Yasuo, Kitamura Yoshiyuki, Yoshidome Satoshi, Hirakawa Kazuya, Takarabe Shinya, Noguchi Yoshitaka, Awamoto Shinichi, Kobayashi Koji, Baba Shingo

    核医学  2022.8  (一社)日本核医学会

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MISC

Committee Memberships

  • Councilor   Domestic

    2023.6 - 2025.6   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

Research Projects

  • 左心補助人工心臓装着に伴う感染症に対するFDG-PET/CTを用いた新たな診断方法の確立

    Grant number:23K07182  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    北村 宜之, 磯田 拓郎, 楠 正興, 山田 明史, 馬場 眞吾, 石神 康生

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    Authorship:Principal investigator  Grant type:Scientific research funding

    左室補助人工心臓(LVAD)の装着が必要となっている患者さんにおいて、LVAD装着後の合併症の一つである装着部の感染症があるが、CT検査など従来の画像検査ではその診断が困難である。本研究では、核医学を用いた検査の一つで、すでに国内でも広く利用されているFDG(F-18 Fluorodeoxyglucose)を用いた検査(FDG-PET/CT)をLVAD装着後の患者さんに行い、検査結果を詳しく調べることで、LVAD装着後感染症の診断に有用な画像診断法を確立する。

    CiNii Research

  • 18F-NaF PETによる前立腺癌骨転移の治療効果予測法の確立

    Grant number:17K10444  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 89Zr-PSMA-PETを用いた新たな前立腺癌の画像診断法の確立

    Grant number:21K07622 

    馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 山田 明史, 石神 康生

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    Grant type:Scientific research funding

    本研究は、前立腺癌病変の描出における89Zr-PMSA PET/CTの有用性について検証し、臨床応用を行うことを目的とする。計画している具体的な研究項目は、89Zr-PMSA合成法の確立と生検結果を基準とした89Zr-PMSA PETの感度・特異度の算出、治療効果との比較の3つである。この方法により前立腺癌病変の非侵襲的な画像診断法を確立する。

    CiNii Research

  • メチオニンPETとAPTイメージングの統合による新たな脳腫瘍診断方法の開発

    Grant number:24K10763 

    楠 正興, 北村 宜之, 三道 幹大, 磯田 拓郎, 栂尾 理, 山田 明史, 石神 康生

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    Grant type:Scientific research funding

    脳腫瘍の特異なアミノ酸代謝を画像化するメチオニンPET(Positron Emission Tomography) は、腫瘍の進展範囲や再発診断などにその有用性が報告されてきた。しかしながら、現時点で主流である静的撮像法(Static Imaging)による術前の腫瘍悪性度の正確な評価は困難とされており、依然発展途上の課題である。本研究では、動的撮像法(Dynamic imaging)により新たな診断パラメータを探索し、これを先進的な分子イメージング技術であるAPT (Amide Proton Transfer)イメージングと統合することで、この課題を克服し悪性度評価の精度向上を目的とする。

    CiNii Research

  • サイクロトロンによるガリウム68標識放射性薬剤の安定製造に関する研究

    Grant number:24K10839 

    馬場 眞吾, 山田 明史, 北村 宜之, 磯田 拓郎

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    Grant type:Scientific research funding

    本研究は、サイクロトロンを利用して各種の68Ga標識PETトレーサーの合成環境を確立させることを目的とする。合成を計画している具体的なトレーサーは、68Ga-PSMA11および68Ga-FAPI04であり、これらの薬剤の安定合成環境の構築を目指す。

    CiNii Research

  • アミノ酸イメージングの拡大を目指した18F標識アミノ酸の新規合成法の確立

    Grant number:19K08100 

    山田 明史, 北村 宜之, 馬場 眞吾, 磯田 拓郎

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    Grant type:Scientific research funding

    18F-FPheおよび18F-FAMTはアミノ酸トレーサーとして脳組織および種々の腫瘍などのアミノ酸輸送過程を、定量的あるいは定性的に診断する薬剤として使用される。現在、18F-FPheおよび18F-FAMTは18F-F2ガスから合成されているが、この方法では1回の合成で得られる放射能量や比放射能が著しく低い。18Fアニオン(18F-)から18F-FPheと18F-FAMTの合成することができれば、この課題は克服できる。

    CiNii Research

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Educational Activities

  • To students: teaching the fundamentals of nuclear medicine examination, method and features and findings of examination images
    To the resident doctor: teaching implementation and diagnosis of nuclear medical examination, understanding treatment methods in RI internal therapy, specific treatment and the way to explanation to patients / families.
    To the medical staff: instructed on basic knowledge of nuclear medicine examination and RI internal medicine therapy, and educates knowledge on examination, treatment, and disease.

Outline of Social Contribution and International Cooperation activities

  • I engage in nuclear medicine diagnosis and treatment at Kyushu University Hospital.
    - diagnosis, explanation of results about examination
    - 131 I Iodine treatment for differentiated thyroid cancer and hyperthyroidism
    - RI-labeled CD20 antibody therapy for low-grade malignant lymphoma
    - Ra-223 treatment for castration-resistant prostate cancer bone metastasis
    We actively participate in study meetings and symposiums on nuclear medicine examination and radiation diagnosis conducted in Japan and abroad, sharing knowledge and enlightenment.
    I conducted education and guidance on medical diagnostic imaging diagnosis and radiation nuclide-based treatment for overseas trainees.

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Radiology

Clinician qualification

  • 診断専門医

    Japan Radiological Society(JRS)

  • Specialist

    Japanese Society of Nuclear Medicine(JSNM)

Year of medical license acquisition

  • 2006