Updated on 2024/07/28

Information

 

写真a

 
ONO FUMITAKA
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
Kyushu University Hospital Dermatology（Joint Appointment）
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425585
Profile
臨床、研究

Degree

  • M.D.,Ph.D.

Research Interests・Research Keywords

  • Research theme：The role of Periostin in murine and human melanoma. Reveal the tumor microenvironment.

    Keyword：Malignant Melanoma, Chronic inflammation, Prognosis, Periostin, Tumor microenvironment

    Research period： 2015.4

Papers

  • Intra- And Inter-Tumor BRAF Heterogeneity in Acral Melanoma: An Immunohistochemical Analysis Invited Reviewed International journal

    Int J Mol Sci. 2019 Dec 8;20(24):6191.   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/ijms20246191.

  • Periostin Links Skin Inflammation to Melanoma Progression in Humans and Mice. Invited Reviewed International journal

    Int J Mol Sci. 2019 Jan; 20(1): 169.   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

Presentations

  • hree prognostic factors in human melanoma; PD-L1 expression is associated with M2 macrophage infiltration but not with stromal periostin International conference

    @Ohno F, @Nakahara T, @Furue M

    5th Eastern Asia Dermatology Congress  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：China  

  • Integration of periostin, M2 macrophages and integrin in human and murine melanoma progression International conference

    @Ohno F, @Nakahara T, @Furue M

    5th Eastern Asia Dermatology Congress, June 21-24, 2018.  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：China  

    Periostin is a multifunctional matricellular protein that has an important role in regulating melanoma behavior. Periostin is also involved induction in tolerogenic CD163+ M2 macrophages. However, a comprehensive study about the relation among periostin, CD163+ M2 macrophages and melanoma progression has poorly investigated. Thus, we examined the prognostic values of periostin and infiltrated M2 macrophages in human and murine melanoma. In human melanoma, we immunohistologically examined the expression of stromal periostin and the infiltration of CD163+ M2 macrophages, and statistically analyzed the associations of these variables with the patients’ histological features, clinical stage, and prognosis. In addition, we established a murine inflammatory skin model that expressed stromal periostin, and investigated the relationship among periostin expression, the number of CD163+ M2 macrophages, and melanoma progression. In human melanomas, high expression of periostin and a large number of infiltrated M2 macrophages were significantly correlated with poor prognosis. In our murine model, B16 melanoma cell growth in the inflamed periostin-high skin was significantly faster than that in control skin. Intriguingly, significantly more number of CD163+ M2 macrophages were recruited in the melanomas in the inflamed periostin-high skin than those in control skin. Both in human and murine melanoma, periostin receptor αVβ5 integrin was preferentially expressed in melanoma cells whereas CD163+ M2 macrophages mainly harbored periostin receptor αVβ3 integrin. These findings stress a critical role of periostin and M2 macrophages in melanoma progression and prognosis irrespective of human and mouse, indicating that periostin may be a potential target in treating progressive melanoma.

  • Essential role of periostin in inflammation-associated melanoma progression in human and mouse International conference

    @F.Ohno, @T.Nakahara, @M.Nakahara, @S.Nunomura, @K.Izuhara, @M.Furue

    European Society of Dermatology Research Sep 27, 2017.  2017.9 

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    Event date： 2017.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Germany  

  • Chronic inflammation promotes melanoma progression - emerging role of periostin - International conference

    @Fumitaka Ohno, @Takeshi Nakahara, @Makiko Nakahara, @Masutaka Furue

    Society for Investigative Dermatology Apr 26, 2017.  2017.4 

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    Event date： 2017.4

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

Travel Abroad

  • 2019.7 - 2020.7

    Staying countory name 1：Mongolia   Staying institution name 1：Mongolian National University of Medical Sciences

    Staying institution name 2：National Cancer Center of Mongolia

    Staying institution name 3：National Dermatology Center of Mongolia

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Dermatology

Clinician qualification

  • Certifying physician

    The Japanese Dermatological Association

Year of medical license acquisition

  • 2011

Notable Clinical Activities

  • 悪性腫瘍