Updated on 2024/10/01

Information

 

写真a

 
MIYACHI YASUTAKA
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
Research: Clinical and basic research on the prevention and treatment of diabetes mellitus. Education: For undergraduate and graduate students, lectures and research instructions in diabetes and endocrinology, respectively.

Degree

  • M.D. (Chiba University, Japan)

  • Ph.D. (Tokyo Medical and Dental University, Japan)

Research Interests・Research Keywords

  • Research theme:Research on prevention and treatment of the onset and progression of diabetes

    Keyword:Diabetes

    Research period: 2013.4

Awards

  • 第4回肝臓と糖尿病・代謝研究会 若手研究奨励賞

    2017.5   日本糖尿病学会と日本肝臓学会   肥満による肝臓への炎症細胞浸潤のメカニズムと糖代謝への影響を明らかにしたこと。

  • 第20回日本心血管内分泌代謝学会学術総会 若手研究奨励賞

    2016.12   日本心血管内分泌代謝学会   肥満による肝臓への炎症細胞浸潤のメカニズムと糖代謝への影響を明らかにしたこと。

Papers

  • High frequency of germline recombination in Nestin-Cre transgenic mice crossed with Glucagon-like peptide 1 receptor floxed mice. International journal

    Yusuke Kajitani, Takashi Miyazawa, Tomoaki Inoue, Nao Kajitani, Masamichi Fujita, Yukina Takeichi, Yasutaka Miyachi, Ryuichi Sakamoto, Yoshihiro Ogawa

    PloS one   18 ( 12 )   e0296006   2023.12   ISSN:1932-6203

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    Language:English   Publishing type:Research paper (scientific journal)  

    The Cre-loxP strategy for tissue-specific gene inactivation has become a widely employed tool in several research studies. Conversely, inadequate breeding and genotyping without considering the potential for non-specific Cre-recombinase expression may lead to misinterpretations of results. Nestin-Cre transgenic mice, widely used for the selective deletion of genes in neurons, have been observed to have an incidence of Cre-line germline recombination. In this study, we attempted to generate neuron-specific Glucagon-like peptide 1 receptor (Glp1r) knock-out mice by crossing mice harboring the Nestin-Cre transgene with mice harboring the Glp1r gene modified with loxP insertion, in order to elucidate the role of Glp1r signaling in the nervous system. Surprisingly, during this breeding process, we discovered that the null allele emerged in the offspring irrespective of the presence or absence of the Nestin-Cre transgene, with a high probability of occurrence (93.6%). To elucidate the cause of this null allele, we conducted breeding experiments between mice carrying the heterozygous Glp1r null allele but lacking the Nestin-Cre transgene. We confirmed that the null allele was inherited by the offspring independently of the Nestin-Cre transgene. Furthermore, we assessed the gene expression, protein expression, and phenotype of mice carrying the homozygous Glp1r null allele generated from the aforementioned breeding, thereby confirming that the null allele indeed caused a global knock-out of Glp1r. These findings suggest that the null allele in the NestinCre-Glp1r floxed breeding arose due to germline recombination. Moreover, we demonstrated the possibility that germline recombination may occur not only during the spermatogenesis at testis but also during epididymal sperm maturation. The striking frequency of germline recombination in the Nestin-Cre driver underscores the necessity for caution when implementing precise breeding strategies and employing suitable genotyping methods.

    DOI: 10.1371/journal.pone.0296006

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  • Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion. International journal

    Masamichi Fujita, Takashi Miyazawa, Keiichiro Uchida, Naohiro Uchida, Shojiro Haji, Seiichi Yano, Norifusa Iwahashi, Tomomi Hatayama, Shunsuke Katsuhara, Shintaro Nakamura, Yukina Takeichi, Maki Yokomoto-Umakoshi, Yasutaka Miyachi, Ryuichi Sakamoto, Yoichiro Iwakura, Yoshihiro Ogawa

    Endocrinology   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/endocr/bqad181

  • Improved endurance capacity of diabetic mice during SGLT2 inhibition: Role of AICARP, an AMPK activator in the soleus. International journal

    Shintaro Nakamura, Yasutaka Miyachi, Akihito Shinjo, Hisashi Yokomizo, Masatomo Takahashi, Kohta Nakatani, Yoshihiro Izumi, Hiroko Otsuka, Naoichi Sato, Ryuichi Sakamoto, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

    Journal of cachexia, sarcopenia and muscle   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcsm.13350

  • Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes. International journal

    Hitoshi Watanabe, Wen Du, Jinsook Son, Lina Sui, Shun-Ichiro Asahara, Irwin J Kurland, Taiyi Kuo, Takumi Kitamoto, Yasutaka Miyachi, Rafael de Cabo, Domenico Accili

    Science translational medicine   15 ( 681 )   eabq4126   2023.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.abq4126

  • Reflections on the state of diabetes research and prospects for treatment.

    Domenico Accili, Wen Du, Takumi Kitamoto, Taiyi Kuo, Wendy McKimpson, Yasutaka Miyachi, Maria Mukhanova, Jinsook Son, Liheng Wang, Hitoshi Watanabe

    Diabetology international   14 ( 1 )   21 - 31   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13340-022-00600-2

  • Differential effect of canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice. International journal

    Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

    The Biochemical journal   479 ( 3 )   425 - 444   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/BCJ20210700

  • Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

    Taiyi Kuo, Wen Du, Yasutaka Miyachi, Prasanna K. Dadi, David A. Jacobson, Daniel Segrè, Domenico Accili

    53   101256 - 101256   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molmet.2021.101256

  • Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets Reviewed

    Yasutaka Miyachi, Taiyi Kuo, Jinsook Son, Domenico Accili

    PLOS ONE   16 ( 11 )   e0260526 - e0260526   2021.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0260526

  • Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice

    Kentaro Mori, Kyoichiro Tsuchiya, Suguru Nakamura, Yasutaka Miyachi, Kumiko Shiba, Yoshihiro Ogawa, Kenichiro Kitamura

    Cardiovascular Diabetology   18 ( 1 )   2019.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12933-019-0886-1

  • Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH

    Kumiko Shiba, Kyoichiro Tsuchiya, Chikara Komiya, Yasutaka Miyachi, Kentaro Mori, Noriko Shimazu, Shinobu Yamaguchi, Naomi Ogasawara, Makoto Katoh, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Scientific Reports   8 ( 1 )   2018.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-19658-7

  • A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition

    Yasutaka Miyachi, Kyoichiro Tsuchiya, Kumiko Shiba, Kentaro Mori, Chikara Komiya, Naomi Ogasawara, Yoshihiro Ogawa

    Scientific Reports   8 ( 1 )   2018.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-34305-x

  • Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

    Chikara Komiya, Miyako Tanaka, Kyoichiro Tsuchiya, Noriko Shimazu, Kentaro Mori, Shunsaku Furuke, Yasutaka Miyachi, Kumiko Shiba, Shinobu Yamaguchi, Kenji Ikeda, Kozue Ochi, Kazuhiko Nakabayashi, Ken-ichiro Hata, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Scientific Reports   7 ( 1 )   2017.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep44754

  • Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

    Yasutaka Miyachi, Kyoichiro Tsuchiya, Chikara Komiya, Kumiko Shiba, Noriko Shimazu, Shinobu Yamaguchi, Michiyo Deushi, Mizuko Osaka, Kouji Inoue, Yuta Sato, Sayaka Matsumoto, Junichi Kikuta, Kenjiro Wake, Masayuki Yoshida, Masaru Ishii, Yoshihiro Ogawa

    Cell Reports   18 ( 11 )   2766 - 2779   2017.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.02.039

  • Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction

    Chikara Komiya, Kyoichiro Tsuchiya, Kumiko Shiba, Yasutaka Miyachi, Shunsaku Furuke, Noriko Shimazu, Shinobu Yamaguchi, Kazuo Kanno, Yoshihiro Ogawa

    PLOS ONE   11 ( 3 )   e0151511 - e0151511   2016.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0151511

  • IgG4-related retroperitoneal fibrosis and sclerosing cholangitis independent of autoimmune pancreatitis. A recurrent case after a 5-year history of spontaneous remission. International journal

    Hideaki Miura, Yasutaka Miyachi

    JOP : Journal of the pancreas   10 ( 4 )   432 - 7   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • Physical Cell-Cell Interaction Regulates Hepatic Glucose Metabolism in Mice

    Kyoichiro Tsuchiya, Yasutaka Miyachi, Chikara Komiya, Kumiko Shiba, Noriko Shimazu, Shinobu Yamaguchi, Mizuko Osaka, Masayuki Yoshida, Koji Inoue, Kenjiro Wake, Yuta Sato, Junichi Kikuta, Masaru Ishii, Yoshihiro Ogawa

    DIABETES  2016.6 

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    Language:English  

    Country:United States  

  • SGLT2阻害薬が肥満糖尿病マウスの骨格筋代謝に与える影響の検討

    中村 慎太郎, 横溝 久, 大塚 裕子, 和泉 自泰, 高橋 政友, 佐藤 直市, 坂本 竜一, 宮地 康高, 宮澤 崇, 馬場 健史, 小川 佳宏

    糖尿病  2022.4 

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    Language:Japanese  

    Country:Japan  

  • 糖代謝における自然免疫受容体Dectin-2の意義

    藤田 政道, 宮澤 崇, 内田 啓一郎, 内田 尚宏, 宮地 康高, 坂本 竜一, 小川 佳宏

    糖尿病  2022.4 

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    Language:Japanese  

    Country:Japan  

  • Sensor Augmented pump(SAP)療法により血糖管理をした膵全摘後糖尿病の2例

    大熊 英之, 辻本 和峰, 増田 誠三郎, 山下 大翔, 震明 あすか, 竹内 崇人, 宮地 康高, 南 勲, 泉山 肇, 橋本 貢士, 吉本 貴宣

    糖尿病  2018.10 

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    Language:Japanese  

    Country:Japan  

  • 原発性副甲状腺機能亢進症を合併した多腺性自己免疫症候群3型の1例

    山下 大翔, 大熊 英之, 辻本 和峰, 関 隆実, 宮地 康高, 南 勲, 橋本 貢士, 泉山 肇, 吉本 貴宣

    糖尿病  2018.10 

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    Language:Japanese  

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  • 急激な体重減少後からの回復期に生じた高インスリン血症を持続血糖モニタリングおよび経口ブドウ糖負荷試験により示した低血糖症の1例

    増田 誠三郎, 大熊 英之, 新津 吉博, 上田 恵利, 松田 祐輔, 竹内 崇人, 村上 正憲, 中野 雄二郎, 辻本 和峰, 宮地 康高, 坊内 良太郎, 南 勲, 泉山 肇, 橋本 貢士, 吉本 貴宣, 小川 佳宏

    日本内分泌学会雑誌  2018.4 

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    Language:Japanese  

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  • マジンドール用量調節時の摂食抑制効果の定量にVisual analog scale(VAS)が有用であった高度肥満症の1例

    大熊 英之, 南 勲, 関 隆実, 山下 大翔, 増田 誠三郎, 小関 紗代, 安藤 真広, 新津 吉博, 宮地 康高, 辻本 和峰, 泉山 肇, 橋本 貢士, 吉本 貴宣

    日本内分泌学会雑誌  2017.12 

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    Language:Japanese  

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  • 高インスリン血性低血糖症の責任病変の特定に難渋した多発神経内分泌腫瘍の1例

    五十嵐 晃子, 安藤 真広, 南 勲, 宮地 康高, 辻本 和峰, 泉山 肇, 橋本 貢士, 工藤 篤, 田邊 稔, 吉本 貴宣

    日本内分泌学会雑誌  2017.12 

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    Language:Japanese  

    Country:Japan  

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MISC

  • HNF1A Mutations and Beta Cell Dysfunction in Diabetes.

    Yasutaka Miyachi, Takashi Miyazawa, Yoshihiro Ogawa

    International journal of molecular sciences   2022.3

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    Language:English  

    DOI: 10.3390/ijms23063222

Professional Memberships

  • The Japan Diabetes Society

  • The Japanese Society of Internal Medicine

Research Projects

  • CD8+T細胞の分化における転写因子FoxO1の制御メカニズムの解明を目指して

    Grant number:22K16398  2022 - 2024

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • CD8陽性T細胞の分化に着目した1型糖尿病の進展抑制を目指した治療法の開発

    Grant number:21K20934  2021 - 2022

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • CD8陽性T細胞の分化に着目した1型糖尿病の進展抑制を目指した治療法の開発

    Grant number:21K20934  2021 - 2022

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Grant type:Scientific research funding

Educational Activities

  • For undergraduate and graduate students, lectures and research instructions in diabetes and endocrinology, respectively.

Class subject

  • 糖尿病(治療)

    2024.4 - 2024.9   First semester

  • 系統医学III 臨床診断学

    2023.10 - 2024.3   Second semester

  • 糖尿病(治療)

    2023.4 - 2023.9   First semester

  • 糖尿病(治療)

    2022.4 - 2022.9   First semester

Travel Abroad

  • 2018.4 - 2021.3

    Staying countory name 1:United States   Staying institution name 1:コロンビア大学メディカルセンター