Language：English  

DOI： 10.1016/j.radcr.2025.04.034

PubMed

Language：English   Publisher：Ejnmmi Reports  

Background: To evaluate whether the combination of amide proton transfer-weighted imaging (APT-WI) and methionine positron emission tomography (MET-PET) enhances the non-invasive prediction of isocitrate dehydrogenase (IDH) mutation status in adult diffuse gliomas. Results: We retrospectively analysed 28 adult patients with histologically confirmed diffuse gliomas who underwent preoperative APT-WI and MET-PET imaging at our institution. Histogram analyses were conducted for both imaging modalities, extracting parameters such as the 10th, 50th, 70th, and 90th percentiles, mean, variance, skewness, and kurtosis. Parameters between IDH-mutant and IDH-wildtype gliomas were compared using the Mann–Whitney U test. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis, and combined models of the two parameters were constructed using multivariable logistic regression. IDH-wildtype gliomas exhibited significantly higher APT-WI 90th percentile (APT<inf>90</inf>) values (median: 3.51%, interquartile range [IQR]: 1.92–4.23%) compared to IDH-mutant gliomas (median: 2.24%, IQR: 1.52–2.85%, p = 0.039). Similarly, IDH-wildtype gliomas showed elevated MET-PET maximum tumour-to-normal ratios (TNR<inf>max</inf>) (median: 2.51, IQR: 2.13–3.41) compared to IDH-mutant gliomas (median: 1.62, IQR: 1.30–2.77, p = 0.020). ROC curve analysis indicated that the combined model of APT<inf>90</inf> and TNR kurtosis achieved an area under the curve of 0.85, demonstrating superior diagnostic accuracy compared to that of single-parameter models. Conclusions: Combining histogram-derived parameters from APT-WI and MET-PET significantly improves the diagnostic accuracy for predicting IDH mutation status in diffuse gliomas. This non-invasive approach may serve as a valuable adjunct for preoperative evaluation and the development of personalised treatment strategies in patients with gliomas.

DOI： 10.1186/s41824-025-00248-6

Web of Science

Scopus

PubMed

Language：English  

DOI： 10.7759/cureus.82340

PubMed

Publisher：メジカルビュー社  

DOI： 10.18885/ci.0000001998

CiNii Research

Language：English   Publisher：Neuroradiology  

Background and purpose: The cortical high-flow sign has been more commonly reported in oligodendroglioma, IDH-mutant and 1p/19q-codeleted (ODG IDHm-codel) compared to diffuse glioma with IDH-wildtype or astrocytoma, IDH-mutant. Besides tumor types, higher grades of glioma might also contribute to the cortical high flow. Therefore, we investigated whether the histological cortical vascular density or CNS WHO grade was associated with the cortical high-flow sign in patients with ODG IDHm-codel. Materials and methods: This retrospective study consisted of pathologically confirmed 25 adult patients with ODG IDHm-codel. We implemented pseudo-continuous arterial spin labeling technique with background suppression. Subtraction images were generated from paired control and label images. Tumor-affecting cortices without intense contrast enhancement on conventional MR imaging were targeted for the determination of the cortical high-flow sign. Immunohistochemical staining of CD31 antibody was performed for the identification of vascular endothelial cells. A microscopic field of the most intense vascularization was captured in each specimen. The vessel number and the relative vascular density (%Vessel) were compared between the positive cortical high-flow sign (CHFS⁺) and the negative cortical high-flow sign (CHFS⁻) groups using the Mann–Whitney U test. Second, Fisher’s exact test was used to compare the difference between the presence or absence of cortical high-flow sign and CNS WHO grades. Finally, the vessel number and %Vessel were compared between the CNS WHO grade 2 and grade 3 using the Mann–Whitney U test. Results: The vessel number and %Vessel were higher in patients with the CHFS⁺ group than in patients with CHFS⁻ group (p = 0.016 and p = 0.005, respectively). We observed no significant differences (p = 1.00) in the frequency of cortical high-flow sign between the CNS WHO grade 2 and grade 3. In addition, no significant differences are found in the vessel number and %Vessel between the CNS WHO grade 2 and grade 3 (p = 0.121 and p = 0.475, respectively). Conclusion: The cortical high-flow sign on ASL, which is more commonly found in ODG IDHm-codel than in diffuse glioma with IDH-wildtype or astrocytoma, is associated with the histological cortical vascular density in patients with ODG IDHm-codel.

DOI： 10.1007/s00234-024-03538-1

Web of Science

Scopus

PubMed

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese   Publisher：(株)メジカルビュー社  

＜文献概要＞★診断のキッカケはどこ?　進展範囲が広いわりに臨床症状が乏しいことがびまん性神経膠腫を疑うキッカケになる。

Language：Japanese   Publisher：産業開発機構(株)  

Type：Peer review 

Number of peer-reviewed articles in foreign language journals：2