記述言語：英語  

DOI： 10.3174/ajnr.A9192

PubMed

記述言語：英語   出版者・発行元：Neuroradiology  

Objectives: To leverage a combination of cortical high-flow sign on arterial spin labeling (ASL) and cystathionine measurement using ¹H-MR spectroscopy (¹H-MRS) to distinguish oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDHm-codel) from astrocytoma, IDH-mutant (A_IDHm-noncodel). Materials and methods: We implemented pseudo-continuous ASL technique (post-labeling delay = 2000 ms) using a 3.0-T MRI scanner. Relative perfusion maps were generated by subtracting paired labeled images from control images. ¹H-MRS data were acquired by using the single-voxel point-resolved spectroscopy sequence (PRESS) sequence (TR = 2000 ms, TE = 97 ms, NEX = 128, volume of interest = 20³ mm³). Our study included cases with a Cramér-Rao Lower Bound of cystathionine levels at 2.7 ppm that were below 50%. The presence or absence of cortical high-flow sign and the estimated concentration of cystathionine were compared between A_IDHm-noncodel and O_IDHm-codel. The receiver operating characteristic curves were used to evaluate the diagnostic performance of each parameter, as well as the combination of both. Results: The cortical high-flow sign was identified more frequent in O_IDHm-codel (7/12, 58.3%) than in A_IDHm-noncodel (3/18, 16.7%; p = 0.018). The cystathionine levels in O_IDHm-codel (1.50 ± 0.63 mM) was significantly higher than in A_IDHm-noncodel (0.85 ± 0.24 mM; p = 0.001). The area under the curve for distinguishing O_IDHm-codel from A_IDHm-noncodel using the presence of cortical high-flow sign, cystathionine levels, and their combination was 0.708 (0.509–0.908), 0.750 (0.553–0.947), and 0.875 (0.737–1.000), respectively. Conclusion: The presence of cortical high-flow sign on ASL, along with elevated cystathionine levels measured by 1H-MRS, could differentiate O_IDHm-codel from A_IDHm-noncodel.

DOI： 10.1007/s00234-026-03909-w

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Neuroradiology  

Purpose: To determine whether relaxometry assessment using synthetic MRI (SyMRI) can predict meningioma consistency. Methods: Eighteen patients with histologically confirmed meningioma were included, and all patients underwent quantitative MRI on a 3T MRI system using a 2D multi-dynamic multi-cho sequence. Quantitative MRI software version 11.3 (SyntheticMR AB, Linköping, Sweden) was used to generate quantitative maps of T1, T2 relaxation times and proton density (PD). Regions of interest were manually placed over all tumor slices to evaluate three parameters (T1, T2, PD). Comparing with the conventional method, relative values of the tumor-to-thalamus signal intensity ratio on the non-contrast T1-weighted image (T1R) and T2-weighted image (T2R) and apparent diffusion coefficients generated from b-values (0 and 1000 s/mm²) of the diffusion-weighted image were also evaluated. The 10^th, 25^th, 50^th, 75^th, and 90^th percentiles and mean values were calculated using histogram analysis. Meningioma consistency was intraoperatively assessed by neurosurgeons using a standardized 5-point scale, with tumors classified as soft (scores 1–2) or hard (scores 3–5). The Mann–Whitney U test and receiver operating characteristic analysis were performed. Results: Soft meningiomas showed significantly longer T1 and T2 relaxation times and higher PDs than hard meningiomas (median value, p-value: 2701 vs. 1721 ms, p = 0.0009 for T1; 111 vs. 94 ms, p = 0.0047 for T2; 92 vs. 85%, p = 0.0092 for PD, respectively). The 90^th percentile of T1 relaxation time exhibited the highest diagnostic performance for differentiating soft from hard meningiomas. Conclusion: Relaxometry assessment offers a reliable method for predicting meningioma consistency that can optimize surgical planning.

DOI： 10.1007/s00234-025-03879-5

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Clinical Neuroradiology  

Purpose: The cerebral blood flow (CBF) measured by multi-delay ASL (4D-ASL) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Dynamic changes in signal intensity (SI) and arterial transit time (ATT) obtained from 4D-ASL may also be key factors in differentiating adult-type diffuse glioma. Furthermore, the longitudinal relaxation time (T1) of brain tumor may influence on CBF and ATT when using ASL techniques. Our purpose was to determine if time-intensity profiles from 4D-ASL using a variable-TR scheme and T1-corrected ATT (ATT<inf>T1corr</inf>) could distinguish among adult-type diffuse gliomas. Materials and Methods: The 4D-ASL with a variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A total of 14 LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATT<inf>T1corr</inf> were compared among adult-type diffuse gliomas. Results: Thirty patients were included in the study. ATT and the SI peak time in diffuse glioma with IDH-wildtype (IDHw) were significantly shorter than astrocytoma, IDH-mutant (p < 0.01, each). Moreover, ATT<inf>T1corr</inf> in astrocytoma, IDH-mutant was longer than the other types of diffuse glioma (p < 0.0001). Conclusion: The 4D-ASL with a variable-TR scheme includes ATT<inf>T1corr</inf> and the SI peak time could potentially improve the differential diagnosis of adult-type diffuse gliomas.

DOI： 10.1007/s00062-026-01616-w

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Ejnmmi Reports  

Background: In positron emission tomography/computed tomography (PET/CT), CT is typically used for attenuation correction during the creation and reconstruction of PET images. Respiratory motion can cause artifacts due to misalignment of PET images, known as respiratory misalignment artifacts (RMA), which occur in up to 30% of lesion-based evaluations, often necessitating rescans of both PET and CT. A new method for reconstructing PET/CT artifacts caused by respiratory motion, termed ‘Enhanced AC’ (EAC) (GE HealthCare, USA), was developed to improve RMA. To evaluate the effectiveness of EAC, radiologists’ visual assessment using a misalignment score is appropriate regardless of the presence or absence of target lesions. This study aimed to assess the usefulness of EAC based on radiologist evaluations. Methods: Consecutive F-18 fluorodeoxyglucose (FDG) PET/CT cases imaged at our hospital between July and August 2024 were included. Two radiologists independently assessed the deviation of FDG-PET/CT images from all cases imaged conventionally. Cases identified by either radiologist as misaligned were designated as the misalignment case group and used for evaluating EAC. A 5-point scoring system was established for the misalignment score. To evaluate the effect of EAC, PET coronal section images from the misalignment case group before EAC adaptation (pre-images) and the EAC-reconstructed images (EAC images) were displayed side by side. Five radiologists independently evaluated both images using a misalignment score. Results: Fifty-four patients (male/female = 36/18, average age 64.1 ± 15.0 years, median 66.5 years) were identified as the misalignment case group. The average misalignment scores from the five radiologists for the pre-images were 3.5, 3.4, 3.3, 3.1, and 3.1, respectively, whereas the scores for the EAC images were significantly lower (p < 0.01) across all radiologists: 2.1, 2.4, 2.5, 2.2, and 1.9, respectively. Conclusions: EAC is an effective and practical method for reducing RMA in selected cases. This method can be easily tailored to individual patients and does not require a large, deep-learning dataset, making it suitable for routine diagnostics.

DOI： 10.1186/s41824-025-00279-z

Web of Science

Scopus

PubMed

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   出版者・発行元：産業開発機構(株)  

記述言語：日本語   出版者・発行元：大道学館出版部  

出版者・発行元：メジカルビュー社  

DOI： 10.18885/ci.0000001998

CiNii Research

記述言語：日本語   出版者・発行元：(株)メジカルビュー社  

＜文献概要＞★診断のキッカケはどこ?　進展範囲が広いわりに臨床症状が乏しいことがびまん性神経膠腫を疑うキッカケになる。

記述言語：日本語   出版者・発行元：産業開発機構(株)  

種別：査読等 

外国語雑誌　査読論文数：2