2024/10/07 更新

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写真a

フジモト シヨウ
藤本 翔
FUJIMOTO SHO
所属
医学研究院 医学教育学部門 助教
医学部 医学科(併任)
職名
助教
連絡先
メールアドレス
電話番号
0926425228

学位

  • 九州大学, 日本

研究テーマ・研究キーワード

  • 研究テーマ: 全身性エリテマトーデスと好塩基球およびIgE型自己抗体の関係

    研究キーワード: 全身性エリテマトーデス、好塩基球、IgE

    研究期間: 2024年4月

論文

  • Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp. equisimilis from Retroperitoneal Panniculitis during the treatment with anti-IL-6 receptor antibody: A Case Report 招待 査読 国際誌

    Sho Fujimoto, Yoshihiro Eriguchi, Rinto Nakamura, Sota Kamikawa, Akiko Yonekawa, Noriko Miyake, Nobuyuki Ono, Hiroaki Niiro

    Mod Rheumatol Case Rep.   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1093/mrcr/rxae001.

  • Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus

    Fujimoto, S; Arinobu, Y; Miyawaki, K; Ayano, M; Mitoma, H; Kimoto, Y; Ono, N; Akashi, K; Horiuchi, T; Niiro, H

    RHEUMATOLOGY   62 ( 10 )   3480 - 3489   2023年10月   ISSN:1462-0324 eISSN:1462-0332

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    記述言語:英語   出版者・発行元:Rheumatology (United Kingdom)  

    Objectives: Recently, the involvement of basophils and IgE-type autoantibodies in the pathogenesis of SLE has been elucidated using mouse models; however, few studies have been conducted in humans. In this study, the role of basophils and anti-double-stranded DNA (dsDNA) IgE in SLE was examined using human samples. Methods: The correlation between disease activity and serum levels of anti-dsDNA IgE in SLE was evaluated using enzyme-linked immunosorbent assay. Cytokines produced by IgE-stimulated basophils from healthy subjects were assessed using RNA sequences. The interaction of basophils and B cells to promote B cell differentiation was investigated using a co-culture system. The ability of basophils from patients with SLE with anti-dsDNA IgE to create cytokines that may be involved in B cell differentiation in response to dsDNA was examined using real-time PCR. Results: Anti-dsDNA IgE levels in the serum of patients with SLE correlated with disease activity. Healthy donor basophils produced IL-3, IL-4 and TGF-β1 after anti-IgE stimulation. Co-culture of B cells with anti-IgE-stimulated basophils increased plasmablasts which were cancelled by neutralizing IL-4. After encountering the antigen, basophils released IL-4 more quickly than follicular helper T cells. Basophils isolated from patients with anti-dsDNA IgE promoted IL-4 expression by adding dsDNA. Conclusions: These results suggest that basophils contribute to the pathogenesis of SLE by promoting B cell differentiation via dsDNA-specific IgE in patients similar to the process described in mouse models.

    DOI: 10.1093/rheumatology/kead082

    Web of Science

    Scopus

    PubMed

  • Clozapine-induced antineutrophil cytoplasmic antibody-associated vasculitis: a case report 招待 査読 国際誌

    Sho Fujimoto, Naoyasu Ueda, Naoya Nishimura, Atsushi Naito, Junki Hiura, Kouichi Mashiba, Ayane Ikai, Kousuke Marutsuka, Kentaro Mizuno

    Mod Rheumatol Case Rep   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: doi: 10.1080/24725625.2019.1628413.

MISC

  • 大型血管炎の画像診断

    藤本 翔, 新納 宏昭

    リウマチ科   71 ( 5 )   488 - 495   2024年5月

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    担当区分:筆頭著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

所属学協会

  • 日本リウマチ学会

  • 日本内科学会

  • 日本感染症学会

専門診療領域

  • 生物系/医歯薬学/内科系臨床医学/膠原病・アレルギー・感染症内科学

臨床医資格

  • 専門医

    日本リウマチ学会

  • 認定医

    日本内科学会

医師免許取得年

  • 2014年