Updated on 2024/10/02

Information

 

写真a

 
KINUGAWA SHINTARO
 
Organization
Faculty of Medical Sciences Research Institute of Angiocardiology Associate Professor
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
School of Medicine Department of Health Sciences(Concurrent)
School of Pharmaceutical Sciences Department of Clinical Pharmacy(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Tel
0926425360
Profile
心不全および心臓リハビリテーションに関する臨床および研究(臨床研究、基礎研究、疫学研究)と循環器内科学全般の教育

Degree

  • PhD

Research History

  • Hokkaido University

Research Interests・Research Keywords

  • Research theme:Elucidation of the molecular mechanism of pathogenesis in heart failure Elucidation of the molecular mechanism of skeletal muscle abnormalities in heart failure Elucidation of factors affecting the limited exercise capacity and development of therapy for heart failure

    Keyword:heart failure, cardiac remodeling, oxidative stress, skeletal muscle, myokine

    Research period: 2020.4 - 2020.7

Awards

  • 日本心臓リハビリテーション学会木村登賞

    2013.7  

  • 第1回日本心不全学会YIA最優秀賞

    1997.10  

Papers

  • Effectiveness of vericiguat on right ventricle to pulmonary artery uncoupling associated with heart failure with reduced ejection fraction Reviewed

    Hashimot T, Yoshitake T, Suenaga T, Yamamoto S, Fujino T, Shinohara K, Matsushima S, Ide T, Kinugawa S, Abe K

    Int J Cardiol   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2024.132441

  • Different impact of immunosuppressive therapy on cardiac outcomes in systemic versus isolated cardiac sarcoidosis Reviewed

    Msunaga T, Hashimot T, Fujino T, Ohtani K, Ishikawa Y, Yoshitake T, Shinotara K, Matsushima S, Ide T, Yamasaki Y, Isoda T, Baba S, Ishigami K, Tsutsui H, Kinugawa S

    Int Heat J   65 ( 5 )   856 - 865   2024.9

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.24-166

  • Right ventricular to pulmonary artery uncoupling is associated with impaired exercise capacity in patients with transthyretin cardiac amyloidosis Reviewed

    Hasimoto T, Ikuta K, Yamamoto S, Yoshitake T, Suenaga T, Nakashima S, Kai T, Misumi K, Fujino T, Shinohara K, Matsushima S, Atsumi R, Isoda T, Kinugawa S, Abe K

    Circ J   2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-24-0402

  • Efficacy and safety of the urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia: results from the LEAF-CHF study Reviewed

    Yokota T, Kinugawa S, Fukushima A, Okumura T, Murohara T, Tsutsui H; LEAF-CHF Investigators

    Heart Vessels   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.10007/s00380-024-02448-9

  • Esaxerenone: blood pressure reduction and cardiorenal protection without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats. Reviewed

    Ikeda S, Shinohara K, Kashihara S, Matsumoto S Yoshida S, Nakashima R, Ono Y, Matsushima S, Tsutsui H, Kinugawa S

    Hypertens Res   47 ( 8 )   2133 - 2143   2024.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-024-01733-4

  • Triglyceride-glucose index associated with future renal function decline in the general population Reviewed

    Yoshida D, Ikeda S, Shinohara K, Kazurayama M, Tanaka S, Yamaizumi M, Nagayoshi H, Toyama K, Kinugawa S

    J Gen Intern Med   2024.5

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11606-024-08809-4

  • The effects of renal denervation on blood pressure, cardiac hypertrophy, and sympathetic activity during the established phase of hypertension in spontaneously hypertensive rats. Reviewed International journal

    Katsuki M, Shinohara K, Kinugawa S, Hirooka Y.

    Hypertens Res   47 ( 4 )   1073 - 1077   2024.4

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  • Perforation of the chest wall from bioprosthetic pulmonary valve endocarditis Reviewed International journal

    Nishizaki A, Ishikita A, Kakino T, Sakamoto I, Shiose A, Kinugawa S

    J Echocardiogr   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12574-024-00647-x

  • Overview of the 87th annual scientific meeting of the Japanese Circulation Society (JCS2023) - New Challenge With Next Generation Reviewed International journal

    Matoba T, Nakano Y Katsuki S, Ide T, Matsushima S, FujinoT, Hashimoto T, Shinohara K, Abe K, Hosokawa K, Sakamoto T, Sakamoto I, Kakino T, Ishikita A, Nishizaki A, Sakamoto K, Takase S, Nagayama T, Tohyama T, Nagata T, Kinugawa S, Tsutsui H

    Circ J   88 ( 4 )   615 - 619   2024.3

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  • Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: comparison with conventional catheters. Reviewed International journal

    Takase S, Mukai Y, Nagaoka K, Ogawa K, Kawai S, Honda N, Nagayama T, Tohyama T, Inoue S, Sadamatsu K, Tashiro H, Sakamoto K, Matoba T, Chishaki A, Kinugawa S, Tsutsui H

    Pacing Clin Electrophysiol   47 ( 1 )   5 - 18   2024.1

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  • Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population Reviewed International journal

    Ikeda S, Shinohara K, Tagawa K, Tohyama T, Kishimoto J, Kazurayama M, Tanaka S, Yamaizumi M, Nagayoshi H, Toyama K, Matsushima S, Tsutsui H, Kinugawa S

    Sci Rep   14 ( 1 )   2024.1

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  • Paced QRS morphology mimicking complete left bundle branch block induced by right ventricular pacing is associated with pacing-induced cardiomyopathy. Reviewed International journal

    Ikeda S, Sakamoto K, Sunagawa M, Yakabe D, Nagaoka K, Kowase S, Inoue S, Morishige K, Mukai Y, Tsutsui H, Kinugaw S

    J Cardiovasc Electrophysiol   2024.1

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  • Hemoglobin level can predict heart failure hospitalization in patients with advanced heart failure awaiting heart transplantation without inotropes or mechanical circulatory support Reviewed

    Suenaga T, Fujino T, Hashimoto T, Ishikawa Y, Shinohara K, Matsushima S, Komman H, Toyosawa M, Ide T, Tsutsui H, Shiose A, Kinugawa S

    Int Heart J   65 ( 4 )   667 - 675   2024

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.24-067

  • Development of deep-learning models for real-time anaerobic threshold and peak VO2 prediction during cardiopulmonary exercise testing. Reviewed International journal

    Watanabe T, Tohyama T, Ikeda M, Fujiono T, Hashimoto T, Matsushima S, Kishimoto J, Todaka K, Kinugawa S, Tsutsui H, Ide T

    Eur J Prev Cardiol   31 ( 4 )   448 - 457   2023.4

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  • The AppCare-HF randomized clinical trial: a feasibility study of a novel self-care support mobile app for individuals with chronic heart failure Reviewed International journal

    Yokota T, Fukushima A, Tsuchihashi-Makaya M, Abe T, Takada S, Furihata T, Ishimori N, Fujno T, Kinugawa S, Ohta M, Kakinoki S, Yokota I, Endoh A, Yoshino M, Tsutsui H

    Eur Heart J Digit Health   4 ( 4 )   325 - 336   2023.2

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  • ZBP1 protects against mtDNA-induced myocardial inflammation in failing hearts Reviewed International journal

    Enzan N, Matsushima S, Ikeda S, Okabe K, Ishikita A, Yamamoto T, Sada M, Miyake R, Tsutsui Y, Nishimura R, Toyohara T, Ikeda Y, Shojima Y, Miyamoto HD, Tadokoro T, Ikeda M, Abe K, Ide T, Kinugawa S, Tsutsui H

    Circ Res   132 ( 9 )   1110 - 1126   2023.2

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  • Enahanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults Reviewed International journal

    Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T

    Sci Rep   13 ( 1 )   5203   2023.1

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  • Nationwide temporal trends in clinical characteristics and treatment of dilated cardiomyopathy from 2003 to 2013 in Japan – A report from clinical personal records Reviewed International journal

    87 ( 4 )   500 - 507   2022.10

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  • Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure Reviewed International journal

    Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H

    Proc Natl Acad Sci USA   119 ( 41 )   2022.10

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  • JCS/JACR 2021 guideline on rehabilitation in patients with cardiovascular disease Reviewed International journal

    Makita S, Yasu T, Akashi YJ, Adachi H, Izawa H, Ishihara S, Iso Y, Ohuchi H, Omiya K, Ohya Y, Okita K, Kimura Y, Koike A, Kohzuki M, Koba S, Sata M, Shimada K, Shimokawa T, Shiraishi H, Sumitomo N, Takahashi T, Takura T, Tsutsui H, Nagayama M, Hasegawa E, Fukuomoto Y, Furukawa Y, Miura S, Yasuda S, Yamada S, Yamada Y, Yumino D, Yoshida T, Adachi T, Ikegame T, Izawa KP, Ishida T, Ozasa N, Osada N, Obata H, Kakutani N, Kasahara Y, Kato M, Kamiya K, Kinugawa S, Kono Y, Kobayashi Y, Koyama T, Sase K, Sato S, Shibata T, Suzuki N, Tamaki D, Yamaoka-Tojo M, Nakanishi M, Nakane E, Nishizaki M, Higo T, Fujimi K, Honda T, Matsumoto Y, Matsumoto N, Miyawaki I, Murata M, Yagi S, Yanase M, Yamada M, Yokoyama M, Watanabe N, Ito H, Kimura T, Kyo S, Goto Y, Nohara R, Hirata K; on behalf of the Japanese Circulation Society/the Japanese Association of Cardiac Rehabilitation Joint Working Group

    Circ J   87 ( 1 )   155 - 235   2022.7

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  • Protect roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation Reviewed International journal

    Tokuyama T, Uosaki H, Sugiura A, Nishitani G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A, Hirai H, Ishido S, Yoshizawa T, Shindo T, Takda S, Kinugawa S, Inatome T, Yanagi S

    iScience   25 ( 7 )   2022.7

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  • Home-based cardiac rehabilitation using information and communication technology for heart failure patients with frailty Reviewed International journal

    Nagatomi Y, Ide T, Nezu T, FujinoT, Yohyama T, Nagata T, Higo T, Hashimoto T, Matsushima S, Shinohara K, Yokoyama T, Eguchi A, Ogusu A, Ikeda M, Ishikawa Y, Yamashita F, Kinugawa S, Tsutsui H

    ESC Heart Fail   2022.4

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  • Diagnostic performance of nutritional indicators in patients with heart failure Reviewed International journal

    Kinugasa Y, Sota T, Kamitani H, Kakutani N, Nakayama N, Nakamura K, Hirai M, Yanagihara K, Kato M, Ono T, Takahashi M, Matsuo H, Matsukawa R, Yoshida I, Himura Y, Yokota T, Yamamoto K, Tsuchihashi-Makaya M, Kinugawa S.

    ESC Heart Fail   2022.2

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  • Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients Reviewed

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Mayumi Yamato, Shingo Takada, Tadashi Suga, Ippei Nakano, Arata Fukushima, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    Scientific Reports   11 ( 1 )   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-81736-0

  • Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice Reviewed

    Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa

    BMC Pharmacology and Toxicology   22 ( 1 )   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40360-021-00495-w

  • Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure Reviewed

    Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa

    Communications Biology   4 ( 1 )   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-021-01675-4

  • JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure. Reviewed

    Hiroyuki Tsutsui, Tomomi Ide, Hiroshi Ito, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Miyuki Makaya, Toyoaki Murohara, Koichi Node, Yoshihiko Saito, Yasushi Sakata, Wataru Shimizu, Kazuhiro Yamamoto, Yasuko Bando, Yu-Ki Iwasaki, Yoshiharu Kinugasa, Isamu Mizote, Hitoshi Nakagawa, Shogo Oishi, Akiko Okada, Atsushi Tanaka, Takashi Akasaka, Minoru Ono, Takeshi Kimura, Shun Kosaka, Masami Kosuge, Shin-Ichi Momomura

    Circulation journal : official journal of the Japanese Circulation Society   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-21-0431

  • GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway Reviewed International journal

    Ishikita A, Matsushima S, Ikeda S, Okabe K, Tadokoro T, Enzan N, Yamamoto T, Sada M, Tsutsui Y, Miyake R, Ikeda M, Ide T, Kinugawa S, Tsutsui H

    iScience   24 ( 12 )   2021.9

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  • JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure. Reviewed International journal

    Hiroyuki Tsutsui, Tomomi Ide, Hiroshi Ito, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Miyuki Makaya, Toyoaki Murohara, Koichi Node, Yoshihiko Saito, Yasushi Sakata, Wataru Shimizu, Kazuhiro Yamamoto, Yasuko Bando, Yu-Ki Iwasaki, Yoshiharu Kinugasa, Isamu Mizote, Hitoshi Nakagawa, Shogo Oishi, Akiko Okada, Atsushi Tanaka, Takashi Akasaka, Minoru Ono, Takeshi Kimura, Shun Kosaka, Masami Kosuge, Shin-Ichi Momomura

    Journal of cardiac failure   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cardfail.2021.04.023

  • Angiotensin-converting enzyme inhibitor prevents skeletal muscle fibrosis in diabetic mice. Reviewed International journal

    Naoya Kakutani, Shingo Takada, Hideo Nambu, Satoshi Maekawa, Hikaru Hagiwara, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Yoshizuki Fumoto, Soichiro Hata, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa

    Experimental physiology   106 ( 8 )   1785 - 1793   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/EP089375

  • JCS/JHFS 2018 Guideline on the Diagnosis and Treatment of Cardiomyopathies.

    Hiroaki Kitaoka, Hiroyuki Tsutsui, Toru Kubo, Tomomi Ide, Taishiro Chikamori, Keiichi Fukuda, Noboru Fujino, Taiki Higo, Mitsuaki Isobe, Chizuko Kamiya, Seiya Kato, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Shigetoyo Kogaki, Issei Komuro, Nobuhisa Hagiwara, Minoru Ono, Yuichiro Maekawa, Shigeru Makita, Yoshiro Matsui, Shouji Matsushima, Yasushi Sakata, Yoshiki Sawa, Wataru Shimizu, Kunihiko Teraoka, Miyuki Tsuchihashi-Makaya, Hatsue Ishibashi-Ueda, Masafumi Watanabe, Michihiro Yoshimura, Arata Fukusima, Satoshi Hida, Shungo Hikoso, Teruhiko Imamura, Hiroko Ishida, Makoto Kawai, Toshiro Kitagawa, Takashi Kohno, Satoshi Kurisu, Yoji Nagata, Makiko Nakamura, Hiroyuki Morita, Hitoshi Takano, Tsuyoshi Shiga, Yasuyoshi Takei, Shinsuke Yuasa, Teppei Yamamoto, Tetsu Watanabe, Takashi Akasaka, Yoshinori Doi, Takeshi Kimura, Masafumi Kitakaze, Masami Kosuge, Morimasa Takayama, Hitonobu Tomoike

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 9 )   1590 - 1689   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-20-0910

  • Impact of citrus fruit intake on the mental health of patients with chronic heart failure Reviewed International journal

    Kakutani N, Yokota T, Fukushima A, Obata Y, Ono T, Sota T, Kinugasa Y, Takahashi M, Matsuo H, Matsukawa R, Yoshida I, Kakinoki S, Yonezawa K, Himura Y, Yokota I, Yamamoto K, Tsuchihashi-Makaya M, Kinugawa S

    J Cardiol   79 ( 6 )   719 - 726   2021.6

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  • Impact of Inadequate Calorie Intake on Mortality and Hospitalization in Stable Patients with Chronic Heart Failure Reviewed

    Yoshikuni Obata, Naoya Kakutani, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shingo Takada, Taisuke Ono, Takeshi Sota, Yoshiharu Kinugasa, Masashige Takahashi, Hisashi Matsuo, Ryuichi Matsukawa, Ichiro Yoshida, Isao Yokota, Kazuhiro Yamamoto, Miyuki Tsuchihashi-Makaya

    Nutrients   13 ( 3 )   874 - 874   2021.3

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    DOI: 10.3390/nu13030874

  • Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ - Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure. Reviewed International journal

    14 ( 1 )   e005890   2021.1

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    BACKGROUND: We recently reported that treatment with rhBDNF (recombinant human brain-derived neurotrophic factor) improved the reduced exercise capacity of mice with heart failure (HF) after myocardial infarction (MI). Since BDNF is reported to enhance fatty acid oxidation, we herein conducted an in vivo investigation to determine whether the improvement in exercise capacity is due to the enhancement of the fatty acid oxidation of skeletal muscle via the AMPKα-PGC1α (adenosine monophosphate-activated protein kinase-ɑ-proliferator-activated receptor-r coactivator-1ɑ) axis. METHODS: MI and sham operations were conducted in C57BL/6J mice. Two weeks postsurgery, we randomly divided the MI mice into groups treated with rhBDNF or vehicle for 2 weeks. AMPKα-PGC1α signaling and mitochondrial content in the skeletal muscle of the mice were evaluated by Western blotting and transmission electron microscopy. Fatty acid β-oxidation was examined by high-resolution respirometry using permeabilized muscle fiber. BDNF-knockout mice were treated with 5-aminoimidazole-4-carboxamide-1-beta-d-riboruranoside, an activator of AMPK. RESULTS: The rhBDNF treatment significantly increased the expressions of phosphorylated AMPKα and PGC1α protein and the intermyofibrillar mitochondrial density in the MI mice. The lowered skeletal muscle mitochondrial fatty acid oxidation was significantly improved in the rhBDNF-treated MI mice. The reduced exercise capacity and mitochondrial dysfunction of the BDNF-knockout mice were improved by 5-aminoimidazole-4-carboxamide-1-beta-d-riboruranoside. CONCLUSIONS: Beneficial effects of BDNF on the exercise capacity of mice with HF are mediated through an enhancement of fatty acid oxidation via the activation of AMPKα-PGC1α in skeletal muscle. BDNF may become a therapeutic option to improve exercise capacity as an alternative or adjunct to exercise training.

    DOI: 10.1161/CIRCHEARTFAILURE.119.005890

  • Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction. Reviewed International journal

    Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai

    Cardiovascular diabetology   19 ( 1 )   142 - 142   2020.9

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    DOI: 10.1186/s12933-020-01114-4

  • Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Reviewed International journal

    Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Masaya Tsuda, Akimichi Saito, Arata Fukushima, Takashi Yokota, Junko Nio-Kobayashi, Hironobu Yasui, Kei Higashikawa, Yuji Kuge, Toshihisa Anzai, Hisataka Sabe, Shintaro Kinugawa

    Cardiovascular research   117 ( 3 )   805 - 819   2020.5

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    DOI: 10.1093/cvr/cvaa127

  • Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter. Reviewed International journal

    Eriko Kawamura, Minako Maruyama, Jiro Abe, Akira Sudo, Atsuhito Takeda, Shingo Takada, Takashi Yokota, Shintaro Kinugawa, Hideyoshi Harashima, Yuma Yamada

    Molecular therapy. Nucleic acids   20   687 - 698   2020.4

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    DOI: 10.1016/j.omtn.2020.04.004

  • Angiotensin-converting-enzym inhibitor prevents skeletal uscle fibrosis in myocardial infarction mice International journal

    Kakutani N, Takada S, Nambu H, Matsumoto J, Furihata T, Yokota T, Fukushima A, Kinugawa S

    Skelet Muscle   2020.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice. Reviewed International journal

    Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Naoya Kakutani, Takaaki Furihata, Mochamad Ali Sobirin, Arata Fukushima, Yoshikuni Obata, Akimichi Saito, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    Experimental physiology   105 ( 3 )   489 - 501   2020.3

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    Language:English  

    DOI: 10.1113/EP087652

  • Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle. Reviewed International journal

    Maekawa S, Takada S, Furihata T, Fukushima A, Yokota T, Kinugawa S

    Biochemistry and biophysics reports   21   100717 - 100717   2020.3

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    Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle.
    Skeletal muscle (SKM) requires a large amount of energy, which is produced mainly by mitochondria, for their daily functioning. Of the several mitochondrial complexes, it has been reported that the dysfunction of complex II is associated with several diseases, including myopathy. However, the degree to which complex II contributes to ATP production by mitochondria remains unknown. As complex II is not included in supercomplexes, which are formed to produce ATP efficiently, we hypothesized that complex II-linked respiration was lower than that of complex I. In addition, differences in the characteristics of complex I and II activity suggest that different factors might regulate their function. The isolated mitochondria from gastrocnemius muscle was used for mitochondrial respiration measurement and immunoblotting in male C57BL/6J mice. Student paired t-tests were performed to compare means between two groups. A univariate linear regression model was used to determine the correlation between mitochondrial respiration and proteins. Contrary to our hypothesis, complex II-linked respiration was not significantly less than complex I-linked respiration in SKM mitochondria (complex I vs complex II, 3402 vs 2840 pmol/[s × mg]). Complex I-linked respiration correlated with the amount of complex I incorporated in supercomplexes (r = 0.727, p < 0.05), but not with the total amount of complex I subunits. In contrast, complex II-linked respiration correlated with the total amount of complex II (r = 0.883, p < 0.05), but not with the amount of each complex II subunit. We conclude that both complex I and II play important roles in mitochondrial respiration and that the assembly of both supercomplexes and complex II is essential for the normal functioning of complex I and II in mouse SKM mitochondria.

    DOI: 10.1016/j.bbrep.2019.100717

  • Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy. Reviewed International journal

    Katsuma Yamanashi, Shintaro Kinugawa, Arata Fukushima, Naoya Kakutani, Shingo Takada, Yoshikuni Obata, Ippei Nakano, Takashi Yokota, Yasuyuki Kitaura, Yoshiharu Shimomura, Toshihisa Anzai

    Life sciences   117593 - 117593   2020.3

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    DOI: 10.1016/j.lfs.2020.117593

  • Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates doxorubicin-induced cardiotoxicity in mice. Reviewed International journal

    Yoshikuni Obata, Naoki Ishimori, Akimichi Saito, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Ippei Nakano, Naoya Kakutani, Katsuma Yamanashi, Toshihisa Anzai

    European journal of preventive cardiology   27 ( 19 )   2047487319901208 - 2047487319901208   2020.3

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    DOI: 10.1177/2047487319901208

  • Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure. Reviewed

    Ippei Nakano, Shintaro Kinugawa, Hiroaki Hori, Arata Fukushima, Takashi Yokota, Shingo Takada, Naoya Kakutani, Yoshikuni Obata, Katsuma Yamanashi, Toshihisa Anzai

    International heart journal   61 ( 1 )   96 - 102   2020.1

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    DOI: 10.1536/ihj.19-400

  • Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure. Reviewed International journal

    Ippei Nakano, Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Naoya Kakutani, Shingo Takada, Takashi Yokota

    Journal of cardiology   76 ( 1 )   109 - 114   2020.1

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    DOI: 10.1016/j.jjcc.2020.01.003

  • Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Reviewed International journal

    Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S

    European journal of pharmacology   866   172810 - 172810   2020.1

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    Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure.
    Decreased exercise capacity, which is an independent predictor of the poor prognosis of patients with heart failure (HF), is attributed to markedly impaired skeletal muscle mitochondrial function and fatty acid oxidation. Previous studies reported that the administration of an inhibitor of sodium-glucose cotransporter 2 (SGLT2) increases ketone body production and fat utilization in type 2 diabetic mice. In this study, we investigated the effects of SGLT2 inhibitor administration on exercise endurance and skeletal muscle mitochondrial function with fatty acid oxidation in a murine model of HF after the induction of myocardial infarction (MI). Two weeks post-MI, HF mice were divided into 2 groups, i.e., with or without treatment with the SGLT2 inhibitor empagliflozin (Empa, 300 mg/kg of food). Consistent with previous studies, urinary glucose and blood beta-hydroxybutyrate levels were increased in the HF+Empa mice compared with the sham and HF mice 4 weeks after the start of Empa administration. Exercise endurance capacity was limited in the HF mice but was ameliorated in the HF+Empa mice, without any effects on cardiac function, food intake, spontaneous physical activity, skeletal muscle strength, and skeletal muscle weight. Mitochondrial oxidative phosphorylation capacity with fatty acid substrates was reduced in the skeletal muscle of HF mice, and this decrease was ameliorated in the HF+Empa mice. Our results demonstrate that SGLT2 inhibitors may be novel therapeutics against reduced exercise endurance capacity in HF, by improving mitochondrial fatty acid oxidation in skeletal muscle.

    DOI: 10.1016/j.ejphar.2019.172810

  • Standard cardiac rehabilitation program for heart failure Reviewed International journal

    Izawa H, Yoshida T, Ikegami T, Izawa KP, Ito Y, Okamura H, Osada N, Kinugawa S, Kubozono T, Kono Y, Kobayashi K, Nishigaki K, Higo T, Hirashiki A, Miyazawa Y, Morio Y, Yanase M, Yamada S, Ikeda H, Momomura SI, Kihara Y, Yamamoto K, Goto Y, Makita S; Japanese Association of Cardiac Rehabilitation Standard Cardiac Rehabilitation Program Planning Committee

    Circ J   83 ( 12 )   2394 - 2398   2019.12

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  • Long-term treatment of tolvaptan in refractory heart failure Reviewed International journal

    Imamura T, Kinugawa S, Muramatsu T, Shiga T, Ogimoto A, Anzai T, Hagiwara N, Tsutsui H, Komuro I, Kinugawa K

    Circ Rep   1 ( 10 )   431 - 437   2019.10

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  • Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Reviewed

    Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T

    Scientific reports   9 ( 1 )   14709   2019.10

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    Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients.

    DOI: 10.1038/s41598-019-51298-3

  • Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. Reviewed International journal

    Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S

    Cell communication and signaling : CCS   17 ( 1 )   128 - 128   2019.10

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    Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure.
    BACKGROUND: Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential nutrient, its excess intake is harmful to health. On the other hand, linoleic acid has been shown to prevent the reduction in cardiolipin content and to improve mitochondrial function in aged rats with spontaneous hypertensive heart failure (HF). In this study, we found that lower dietary intake of linoleic acid in HF patients statistically correlates with greater severity of HF, and we investigated the mechanisms therein involved. METHODS: HF patients, who were classified as New York Heart Association (NYHA) functional class I (n = 45), II (n = 93), and III (n = 15), were analyzed regarding their dietary intakes of different fatty acids during the one month prior to the study. Then, using a mouse model of HF, we confirmed reduced cardiolipin levels in their cardiac myocytes, and then analyzed the mechanisms by which dietary supplementation of linoleic acid improves cardiac malfunction of mitochondria. RESULTS: The dietary intake of linoleic acid was significantly lower in NYHA III patients, as compared to NYHA II patients. In HF model mice, both CI-based and CII-based OXPHOS activities were affected together with reduced cardiolipin levels. Silencing of CRLS1, which encodes cardiolipin synthetase, in cultured cardiomyocytes phenocopied these events. Feeding HF mice with linoleic acid improved both CI-based and CII-based respiration as well as left ventricular function, together with an increase in cardiolipin levels. However, although assembly of the respirasome (i.e., CI/CIII2/CIV complex), as well as assembly of CII subunits and the CIII2/CIV complex statistically correlated with cardiolipin levels in cultured cardiomyocytes, respirasome assembly was not notably restored by dietary linoleic acid in HF mice. Therefore, although linoleic acid may significantly improve both CI-based and CII-based respiration of cardiomyocytes, respirasomes impaired by HF were not easily repaired by the dietary intake of linoleic acid. CONCLUSIONS: Dietary supplement of linoleic acid is beneficial for improving cardiac malfunction in HF, but is unable to completely cure HF.

    DOI: 10.1186/s12964-019-0445-0

  • JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version. Reviewed

    Tsutsui H, Isobe M, Ito H, Okumura K, Ono M, Kitakaze M, Kinugawa K, Kihara Y, Goto Y, Komuro I, Saiki Y, Saito Y, Sakata Y, Sato N, Sawa Y, Shiose A, Shimizu W, Shimokawa H, Seino Y, Node K, Higo T, Hirayama A, Makaya M, Masuyama T, Murohara T, Momomura SI, Yano M, Yamazaki K, Yamamoto K, Yoshikawa T, Yoshimura M, Akiyama M, Anzai T, Ishihara S, Inomata T, Imamura T, Iwasaki YK, Ohtani T, Onishi K, Kasai T, Kato M, Kawai M, Kinugasa Y, Kinugawa S, Kuratani T, Kobayashi S, Tanaka A, Toda K, Noda T, Nochioka K, Hatano M, Hidaka T, Fujino T, Makita S, Yamaguchi O, Ikeda U, Kimura T, Kohsaka S, Kosuge M, Yamagishi M, Yamashina A, Japanese Circulation Society, the Japanese Heart Failure Society Joint, Working Group

    Circulation Journal   83 ( 10 )   2084 - 2184   2019.9

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    JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version.

    DOI: 10.1253/circj.CJ-19-0342

  • Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure. Reviewed International journal

    Nakano I, Hori H, Fukushima A, Yokota T, Kinugawa S, Takada S, Yamanashi K, Obata Y, Kitaura Y, Kakutani N, Abe T, Anzai T

    Journal of cardiac failure   26 ( 8 )   685 - 693   2019.9

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    Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure.
    BACKGROUND: Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo intensity (EI) is associated with exercise capacity in patients with HF. METHODS AND RESULTS: Fifty-eight patients with HF (61 ± 12 years) and 28 control subjects (58 ± 14 years) were studied. The quadriceps femoris echo intensity (QEI) was significantly higher and the quadriceps femoris muscle thickness (QMT) was significantly lower in the patients with HF than the controls (88.3 ± 13.4 vs 81.1 ± 7.5, P= .010; 5.21 ± 1.10 vs 6.54 ±1.34 cm, P< .001, respectively). By univariate analysis, QEI was significantly correlated with age, peak oxygen uptake (VO2), and New York Heart Association class in the HF group. A multivariable analysis revealed that the QEI was independently associated with peak VO2 after adjustment for age, gender, body mass index, and QMT: β-coefficient = -11.80, 95%CI (-20.73, -2.86), P= .011. CONCLUSION: Enhanced EI in skeletal muscle was independently associated with lowered exercise capacity in HF. The measurement of EI is low-cost, easily accessible, and suitable for assessment of HF-related alterations in skeletal muscle quality.

    DOI: 10.1016/j.cardfail.2019.09.001

  • Heterogeneity in the vasodilatory function of individual extremities Reviewed

    Kadoguchi T, Horiuchi M, Kinugawa S, Okita K

    Vascular   doi: 10.1177/1708538119868411   2019.8

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    Heterogeneity in the vasodilatory function of individual extremities

  • A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Reviewed

    Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y

    Mitochondrion   49   66 - 72   2019.7

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    A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells.

    DOI: 10.1016/j.mito.2019.07.005

  • Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial -

    Hiroyuki Tsutsui, Shin-ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa, Koji Oba, Norihiro Sato, Yoshio Yasumura, Shinya Hiramitsu, Yukihito Satou, Takayuki Inomata, Katsuya Onishi, Yasushi Sakata, Kyoichi Mizuno, Kenji Sunagawa, Hisao Ogawa, Mitsuaki Isobe, Hiroyuki Daida, Masahiko Kurabayashi, Shintaro Kinugawa, Tetsuro Kohya, Yuji Ogawa, Naofumi Itoh, Shigeo Kakinoki, Kenji Aoki, Akihito Tsuchida, Hiroshi Ito, Osamu Yamaguchi, Yutaka Eki, Shigeru Toyoda, Akihiko Nakano, Norimichi Koitabashi, Toshihiro Muramatsu, Hideo Nakahara, Hiroyuki Tanaka, Akira Yamashina, Kiyoshi Takasu, Yasuhiro Maejima, Yukihiko Momiyama, Iwao Nakamura, Keisuke Kida, Takashi Naruke, Hideshi Takenobu, Tohru Minamino, Masahiko Nakamura, Masatoshi Ikeda, Kazuhiro Ashida, Shigekiyo Takahashi, Shinya Minatoguchi, Satoru Suwa, Hiroshi Satoh, Hideo Izawa, Hidekatsu Fukuta, Naoya Tsuboi, Hiroyasu Uzui, Atsuyuki Wada, Takeshi Kimura, Ken Takenaka, Takao Kato, Masaaki Okutsu, Tomohito Ohtani, Shinji Hasegawa, Toshihisa Anzai, Kenshi Fujii, Ichiro Shiojima, Yoshinori Yasaka, Tohru Masuyama, Ken-ichi Hirata, Yoshihiko Saito, Takashi Akasaka, Hiroshi Ito, Yasuki Kihara, Ritsu Tamura, Hiroki Teragawa, Kotaro Yasuda, Koichiro Okuhara, Eiji Karashima, Masataka Sata, Akira Ota, Takahisa Noma, Jun Suzuki, Kouki Watanabe, Hiroaki Kitaoka, Ryuichi Matsukawa, Takeshi Yoshihiro, Nobuhide Tanaka, Kiyoshi Ozumi, Masaru Takahashi, Koji Maemura, Nobuhiko Atsuchi

    CIRCULATION JOURNAL   83 ( 6 )   1269 - +   2019.6

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    DOI: 10.1253/circj.CJ-18-1199

  • Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms. Reviewed

    Komoriyama H, Fukushima A, Takahashi Y, Kinugawa S, Sera F, Ohtani T, Nakamura A, Sakata Y, Anzai T

    Internal medicine (Tokyo, Japan)   58 ( 17 )   2545 - 2549   2019.5

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    Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms.
    © 2019 Japanese Society of Internal Medicine. All rights reserved. Becker muscular dystrophy (BMD) carriers are at risk to developing cardiac dysfunction. The prevalence of female BMD carriers remains underestimated, and the disease progression varies. We herein report the case of a young female BMD carrier who developed dilated cardiomyopathy (DCM) and heart failure without any skeletal muscle signs. Her cardiac dysfunction progressed over a mere two months, resulting in the need for left ventricular assist device implantation. Her case demonstrates that progressive cardiomyopathy can be the only clinical manifestation in some BMD carriers, suggesting the need for a more aggressive implementation of genetic testing in female DCM patients.

    DOI: 10.2169/internalmedicine.2714-19

  • Clinical impacts and associated factors of delayed ambulation in patients with acute heart failure Reviewed International journal

    Ishikawa K, Fukushima A, Yokota T, Takada S, Furihata T, Kakutani N, Yamanashi K, Obata Y, Nakano I, Abe T, Kinugawa S, Anzai T

    Circ Rep   1 ( 4 )   179 - 186   2019.4

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  • Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Reviewed International journal

    Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S

    Scientific reports   9 ( 1 )   3535 - 3535   2019.3

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    Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis.
    Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.

    DOI: 10.1038/s41598-019-40419-7

  • Progressive mobilization program for patients with acute heart failure reduces the hospital stay and improves clinical outcomes Reviewed International journal

    Kakutani N, Fukushima A, Kinugawa S, Yokota T, Oikawa T, Nishikawa M, Nakamura R, Tsukada T, Mori S, Yoshida I, Anzai T

    Circ Rep   1 ( 3 )   123 - 130   2019.3

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  • Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder Reviewed International journal

    Li M, Hirano K, Ikeda Y, Higashi M, Hashimoto C, Zhang B, Kozawa J, Sugimura K, Miyauchi H, Suzuki A, Hara Y, Takagi A, Ikeda Y, Kobayashi K, Futsukaichi Y, Zaima N, Yamaguchi S, Shrestha R, Nakamura H, Kawaguchi K, Sai E, Hui SP, Nakano Y, Sawamura A, Inaba T, Sakata Y, Yasui Y, Nagasawa Y, Kinugawa S, Shimada K, Yamada S, Hao H, Nakatani D, Ide T, Amano T, Naito H, Nagasaka H, Kobayashi K, on behlf of the Japan TGCV study group

    Orphanet J Rare Dis   14 ( 1 )   134   2019.1

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  • Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort Reviewed International journal

    Okita K, Takada S, Morita N, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S

    Appl Physiol Nutr Metab   2018 Dec 19 ( 7 )   759 - 764   2018.12

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    Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort
    Increases in muscle size and strength similar to those obtained with high resistance load can be achieved by combining lower loads with continuous blood flow restriction (BFR). However, high ratings for distress have been reported for continuous BFR. Therefore, we investigated the efficacy (metabolic stress) of BFR applied only during intervals in resistance exercise. Seven healthy men performed three 1-min sets of plantar flexion (30 reps/min) with 1-min rest intervals under 4 conditions: low-load resistance exercise (L, 20% 1-repetition maximum (1RM)) without BFR (L-noBFR), L with BFR during exercise sets (L-exBFR), L with BFR during rest intervals (L-intBFR), and L with continuous BFR during both exercise and rest intervals (L-conBFR). Based on the results of the first experiment, we performed additional protocols using a moderate load (M, 40% 1RM) with intermittent (exercise or rest intervals) BFR (M-exBFR and M-intBFR). Intramuscular metabolic stress, defined as decreases in phosphocreatine and intramuscular pH, was evaluated by 31P magnetic resonance spectroscopy. Rated perceived exertion (RPE) was also assessed. At the end of exercise, total decreases in phosphocreatine and intramuscular pH were similar among L-noBFR, L-intBFR, and L-exBFR and significantly less than those in L-conBFR (p < 0.05). In contrast, changes in these variables in M-intBFR but not in M-exBFR were similar to those in L-conBFR. Nevertheless, RPE was lower in M-intBFR than in both M-exBFR and L-conBFR (p < 0.05). The effect of intermittent BFR during exercise might be insufficient to induce metabolic stress when using a low load. However, effective metabolic stress for muscle adaptation could be obtained by moderate-load resistance exercise with BFR during intervals with less ischemic duration and discomfort.

    DOI: 10.1139/apnm-2018-0321

  • Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure. Reviewed

    Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T

    Circulation   138 ( 18 )   2064 - 2066   2018.10

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    Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure.

    DOI: 10.1161/CIRCULATIONAHA.118.035212

  • Impact of High Respiratory Exchange Ratio During Submaximal Exercise on Adverse Clinical Outcome in Heart Failure Reviewed

    Kakutani N, Fukushima A, Yokota T, Katayama T, Nambu H, Shirakawa R, Maekawa S, Abe T, Takada S, Furihata T, Ono K, Okita K, Kinugawa S, Anzai T

    Circ J   2018.8

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    Impact of High Respiratory Exchange Ratio During Submaximal Exercise on Adverse Clinical Outcome in Heart Failure

  • Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure Reviewed

    Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T

    J Cachexia Sarcopenia Muscle   2018.8

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    Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

  • Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure. Reviewed

    Fukuda H, Shindo K, Sakamoto M, Ide T, Kinugawa S, Fukushima A, Tsutsui H, Ito S, Ishii A, Washio T, Kitakaze M

    EBioMedicine   33   185 - 195   2018.7

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    Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure.

    DOI: 10.1016/j.ebiom.2018.06.001

  • Hyponatremia as a surrogate marker for optimal diuretic selection in acute heart failure. Reviewed

    Fukushima A, Kinugawa S

    Journal of cardiology   71 ( 6 )   547 - 549   2018.6

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    Hyponatremia as a surrogate marker for optimal diuretic selection in acute heart failure.

    DOI: 10.1016/j.jjcc.2017.10.013

  • Malnutrition in Heart Failure: Important But Undervalued Issue. Reviewed

    Kinugawa S, Fukushima A

    JACC. Heart failure   2018.5

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    Malnutrition in Heart Failure: Important But Undervalued Issue.

    DOI: 10.1016/j.jchf.2018.03.014

  • Randomized trial of effect of urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia (LEAF-CHF): study design Reviewed International journal

    Yokota T, Fukushima A, Kinugawa S, Okumura T, Murohara T, Tsutsui H

    Int Heart J   59 ( 5 )   976 - 982   2018.5

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  • The impact of creating mathematical formula to predict cardiovascular events in patients with heart failure. Reviewed

    Sakamoto M, Fukuda H, Kim J, Ide T, Kinugawa S, Fukushima A, Tsutsui H, Ishii A, Ito S, Asanuma H, Asakura M, Washio T, Kitakaze M

    Scientific reports   8 ( 1 )   3986   2018.3

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    The impact of creating mathematical formula to predict cardiovascular events in patients with heart failure.

    DOI: 10.1038/s41598-018-22347-0

  • Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure Reviewed

    Hiroyuki Sawatari, Mari K. Nishizaka, Mami Miyazono, Shin-ichi Ando, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Daisuke Goto, Tomoo Furumoto, Shintaro Kinugawa, Nobuko Hashiguchi, Anita Rahmawati, Hiroaki Chishaki, Tomoko Ohkusa, Chie Magota, Hiroyuki Tsutsui, Akiko Chishaki

    Heart and Vessels   33 ( 2 )   155 - 162   2018.2

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    DOI: 10.1007/s00380-017-1047-7

  • Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy Reviewed International journal

    Kadoguchi T, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Mizushima W, Fukushima A, Okita K, Kinugawa S

    Biomed Res Int   2018   3194917 - 3194917   2018.1

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    Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy
    Skeletal muscle atrophy is induced by an imbalance between protein synthesis and degradation. Our previous studies reported that angiotensin II (AII) directly induced muscle atrophy in mice. This study investigated the role of NAD(P)H oxidase 2 (Nox2) activation by AII in the induction of skeletal muscle atrophy. For 4 weeks, either saline (vehicle: V) or AII (1000 ng kg-1 min-1) was infused into male wild-type (WT) and Nox2 knockout (KO) mice via osmotic minipumps. Experiments were performed in the following 4 groups: WT + V, KO + V, WT + AII, and KO + AII. Body weight, muscle weight, and myocyte cross-sectional area were significantly decreased in WT + AII compared to WT + V mice, and these changes were not observed in KO + AII mice. Akt phosphorylation of Ser473 and p70S6K of Thr389 was decreased, gene expression levels of MuRF-1 and atrogin-1 were increased in WT + AII compared to WT + V, and these changes were significantly attenuated in KO + AII mice. The deletion of Nox2 prevented AII-induced skeletal muscle atrophy via improving the balance between protein synthesis and degradation. Therefore, Nox2 may be a therapeutic target for AII-induced skeletal muscle atrophy.

    DOI: 10.1155/2018/3194917

  • Diagnostic criteria and severity score for triglyceraide deposit cardiomyovasculopathy Reviewed International journal

    Miyauchi H, Hashimoto C, Ikeda Y, Li M, Nakano Y, Kozawa J, Sai E, Nagasawa Y, Kinugawa S, Kawaguchi K, Shimada K, Ide T, Amano T, Higashi M, Inaba T, Nakamura H, Kobayashi K, Hirano K

    Ann Nucl Cardiol   4 ( 1 )   94 - 100   2018.1

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  • Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome Reviewed

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Masashige Takahashi, Arata Fukushima, Shouji Matsushima, Mayumi Yamato, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF DIABETES INVESTIGATION   8 ( 4 )   535 - 541   2017.7

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    DOI: 10.1111/jdi.12606

  • Angiotensin II and skeletal muscle abnormalities Reviewed

    Shintaro Kinugawa

    EXPERIMENTAL PHYSIOLOGY   102 ( 6 )   614 - 615   2017.6

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    DOI: 10.1113/EP086216

  • Renin-Angiotensin-Aldosterone System and Natriuretic Peptides as Possible Targets of Waon Therapy in Heart Failure Reviewed

    Arata Fukushima, Shintaro Kinugawa

    CIRCULATION JOURNAL   81 ( 5 )   635 - 636   2017.5

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    DOI: 10.1253/circj.CJ-17-0286

  • The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes Reviewed

    Wataru Mizushima, Hidehisa Takahashi, Masashi Watanabe, Shintaro Kinugawa, Shouji Matsushima, Shingo Takada, Takashi Yokota, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Ikuru Chiba, Shun Nagashima, Shigeru Yanagi, Masaki Matsumoto, Keiichi I. Nakayama, Hiroyuki Tsutsui, Shigetsugu Hatakeyama

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   100   43 - 53   2016.11

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    DOI: 10.1016/j.yjmcc.2016.09.013

  • Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure. Reviewed International journal

    Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Takashi Yokota, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

    International journal of cardiology   220   483 - 7   2016.10

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    DOI: 10.1016/j.ijcard.2016.06.231

  • Fyn is a physiological regulator of Nox4 in the heart Reviewed International journal

    Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J

    J Clin Invest   126 ( 9 )   3403 - 3416   2016.9

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  • Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling Reviewed

    Shouji Matsushima, Junya Kuroda, Peiyong Zhai, Tong Liu, Shohei Ikeda, Narayani Nagarajan, Shin-ichi Oka, Takashi Yokota, Shintaro Kinugawa, Chiao-Po Hsu, Hong Li, Hiroyuki Tsutsui, Junichi Sadoshima

    JOURNAL OF CLINICAL INVESTIGATION   126 ( 9 )   3403 - 3416   2016.9

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    DOI: 10.1172/JCI85624

  • Successful Evaluation for Reversibility of Pulmonary Hypertension Using Inhaled Nitric Oxide Determining Candidate for Heart Transplantation Reviewed

    Omote Kazunori, Sakakibara Mamoru, Nanbu Hideo, Maekawa Satoshi, Asakawa Naoya, Noguchi Keiji, Tokuda Yusuke, Kamiya Kiwamu, Kinugawa Shintaro, Tsutsui Hiroyuki

    JOURNAL OF CARDIAC FAILURE   22 ( 9 )   S228 - S229   2016.9

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    Successful Evaluation for Reversibility of Pulmonary Hypertension Using Inhaled Nitric Oxide Determining Candidate for Heart Transplantation

    DOI: 10.1016/j.cardfail.2016.07.402

  • Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling Reviewed

    Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takaaki Furihata, Wataru Mizushima, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Masashige Takahashi, Shinichi Harashima, Shouji Matsushima, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsui

    CARDIOVASCULAR RESEARCH   111 ( 4 )   338 - 347   2016.9

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    DOI: 10.1093/cvr/cvw182

  • The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice. Reviewed International journal

    Takaaki Furihata, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Masashige Takahashi, Tsuneaki Homma, Yoshihiro Masaki, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Shouji Matsushima, Takashi Yokota, Hiroyuki Tsutsui

    International journal of cardiology. Heart & vasculature   11   24 - 28   2016.6

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    DOI: 10.1016/j.ijcha.2016.03.007

  • Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice Reviewed

    Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Junichi Matsumoto, Takaaki Furihata, Wataru Mizushima, Masaya Tsuda, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    EUROPEAN JOURNAL OF PHARMACOLOGY   779   147 - 156   2016.5

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    DOI: 10.1016/j.ejphar.2016.03.022

  • Low-intensity exercise under ischemic conditions enhances metabolic stress in patients with heart failure Reviewed

    Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Kagami Hirabayashi, Takashi Yokota, Shouji Matsushima, Akimichi Saito, Koichi Okita, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   201   142 - 144   2015.12

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    DOI: 10.1016/j.ijcard.2015.08.022

  • Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes Reviewed

    Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Daisuke Takemoto, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Yoshiko Ono, Hiroshi Shibata, Koichi Okita, Hiroyuki Tsutsui

    EXPERIMENTAL PHYSIOLOGY   100 ( 11 )   1319 - 1330   2015.11

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    DOI: 10.1113/EP085251

  • Curcumin ameliorates skeletal muscle atrophy in type 1 diabetic mice by inhibiting protein ubiquitination Reviewed

    Taisuke Ono, Shingo Takada, Shintaro Kinugawa, Hiroyuki Tsutsui

    EXPERIMENTAL PHYSIOLOGY   100 ( 9 )   1052 - 1063   2015.9

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    DOI: 10.1113/EP085049

  • Skeletal Muscle Abnormalities in Heart Failure Reviewed

    Shintaro Kinugawa, Shingo Takada, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    INTERNATIONAL HEART JOURNAL   56 ( 5 )   475 - 484   2015.9

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    DOI: 10.1536/ihj.15-108

  • AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress Reviewed

    Mikito Nishikawa, Naoki Ishimori, Shingo Takada, Akimichi Saito, Tomoyasu Kadoguchi, Takaaki Furihata, Arata Fukushima, Shouji Matsushima, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

    NEPHROLOGY DIALYSIS TRANSPLANTATION   30 ( 6 )   934 - 942   2015.6

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    DOI: 10.1093/ndt/gfv103

  • Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure. Reviewed International journal

    Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takashi Yokota, Shouji Matsushima, Shingo Takada, Tomoyasu Kadoguchi, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

    Journal of cardiac failure   21 ( 4 )   300 - 6   2015.4

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    DOI: 10.1016/j.cardfail.2015.01.003

  • Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle Reviewed

    Tomoyasu Kadoguchi, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Takaaki Furihata, Tsuneaki Homma, Yoshihiro Masaki, Wataru Mizushima, Mikito Nishikawa, Masashige Takahashi, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    EXPERIMENTAL PHYSIOLOGY   100 ( 3 )   312 - 322   2015.3

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    DOI: 10.1113/expphysiol.2014.084095

  • Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity Reviewed

    Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Arata Fukushima, Tadashi Suga, Masashige Takahashi, Taisuke Ono, Noriteru Morita, Masashi Omokawa, Kuniaki Harada, Noriko Oyama-Manabe, Hiroaki Shirato, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   176 ( 3 )   1110 - 1112   2014.10

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    DOI: 10.1016/j.ijcard.2014.07.113

  • Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice Reviewed

    Shingo Takada, Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Shouji Matsushima, Tadashi Suga, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Wataru Mizushima, Yoshihiro Masaki, Takaaki Furihata, Ryoichi Katsuyama, Koichi Okita, Hiroyuki Tsutsui

    EUROPEAN JOURNAL OF PHARMACOLOGY   740   690 - 696   2014.10

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    DOI: 10.1016/j.ejphar.2014.06.008

  • (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice Reviewed

    Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Shouji Matsushima, Mochamad Ali Sobirin, Taisuke Ono, Masashige Takahashi, Tadashi Suga, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM   307 ( 6 )   E503 - E514   2014.9

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    DOI: 10.1152/ajpendo.00449.2013

  • Clinical characteristics and CHADS(2) score in patients with heart failure and atrial fibrillation: Insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Shouji Matsushima, Arata Fukushima, Takashi Yokota, Mamoru Sakakibara, Hisashi Yokoshiki, Miyuki Tsuchihashi-Makaya, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   176 ( 1 )   239 - 242   2014.9

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    DOI: 10.1016/j.ijcard.2014.06.068

  • Assessment of Quality of Life During Long-Term Treatment of Tolvaptan in Refractory Heart Failure Design and Rationale of the AQUA-TLV Study Reviewed

    Teruhiko Imamura, Koichiro Kinugawa, Tomohito Ohtani, Yasushi Sakata, Taiki Higo, Shintaro Kinugawa, Hiroyuki Tsutsui, Kenji Sunagawa, Issei Komuro

    INTERNATIONAL HEART JOURNAL   55 ( 3 )   264 - 267   2014.5

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    DOI: 10.1536/ihj.13-326

  • Weekend versus weekday hospital admission and outcomes during hospitalization for patients due to worsening heart failure: a report from Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Hiroyuki Tsutsui

    HEART AND VESSELS   29 ( 3 )   328 - 335   2014.5

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    DOI: 10.1007/s00380-013-0359-5

  • Hyponatremia is an independent predictor of adverse clinical outcomes in hospitalized patients due to worsening heart failure Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Shouji Matsushima, Mamoru Sakakibara, Naoki Ishimori, Daisuke Goto, Hiroyuki Tsutsui

    JOURNAL OF CARDIOLOGY   63 ( 3-4 )   182 - 188   2014.3

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    DOI: 10.1016/j.jjcc.2013.07.012

  • Combination of Exercise Training and Diet Restriction Normalizes Limited Exercise Capacity and Impaired Skeletal Muscle Function in Diet-Induced Diabetic Mice Reviewed

    Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A. Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsui

    ENDOCRINOLOGY   155 ( 1 )   68 - 80   2014.1

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    DOI: 10.1210/en.2013-1382

  • Report of the American Heart Association (AHA) Scientific Sessions 2013, Dallas Reviewed

    Naoki Ishimori, Shintaro Kinugawa, Satoshi Yamada, Hisashi Yokoshiki, Hirofumi Mitsuyama, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   78 ( 1 )   51 - 56   2014.1

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    DOI: 10.1253/circj.CJ-13-1466

  • Resistance exercise with blood flow restriction in women Invited Reviewed

    Okita K, Takada S, Suga T, Kadoguchi T, Taniura T, Morita N, Yokota T, Kinugawa S, Tsutsui H

    Proceeding of Asian Federation of Sports Medicine   73 - 75   2013.12

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    Resistance exercise with blood flow restriction in women

  • Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy Reviewed

    Takashi Fujita, Noboru Fujino, Ryuichiro Anan, Chuwa Tei, Toru Kubo, Yoshinori Doi, Shintaro Kinugawa, Hiroyuki Tsutsui, Shigeki Kobayashi, Masafumi Yano, Masanori Asakura, Masafumi Kitakaze, Issei Komuro, Tetsuo Konno, Kenshi Hayashi, Masa-aki Kawashiri, Hidekazu Ino, Masakazu Yamagishi

    JACC-HEART FAILURE   1 ( 6 )   459 - 466   2013.12

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    DOI: 10.1016/j.jchf.2013.08.007

  • Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure. Reviewed International journal

    Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takashi Yokota, Shouji Matsushima, Takahiro Abe, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Ryoichi Katsuyama, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

    International journal of cardiology   168 ( 5 )   e142-4 - 4   2013.10

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    DOI: 10.1016/j.ijcard.2013.08.073

  • Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure Reviewed

    Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takahiro Abe, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Shouji Matsushima, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   168 ( 4 )   4313 - 4314   2013.10

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    DOI: 10.1016/j.ijcard.2013.04.176

  • Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice. Reviewed

    62   179 - 188   2013.9

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    DOI: 10.1016/j.yjmcc.2013.06.004

  • Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

    JOURNAL OF CARDIOLOGY   62 ( 1-2 )   95 - 101   2013.7

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    DOI: 10.1016/j.jjcc.2013.03.009

  • Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome Reviewed

    Takashi Yokota, Shintaro Kinugawa, Mayumi Yamato, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Kuniaki Harada, Noriteru Morita, Noriko Oyama-Manabe, Yasuka Kikuchi, Koichi Okita, Hiroyuki Tsutsui

    DIABETES CARE   36 ( 5 )   1341 - 1346   2013.5

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    DOI: 10.2337/dc12-1161

  • Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice Reviewed

    Shingo Takada, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Mochamad A. Sobirin, Yoshihiro Masaki, Wataru Mizushima, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF APPLIED PHYSIOLOGY   114 ( 7 )   844 - 857   2013.4

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    DOI: 10.1152/japplphysiol.00053.2012

  • Home-Based Disease Management Program to Improve Psychological Status in Patients With Heart Failure in Japan Reviewed

    Miyuki Tsuchihashi-Makaya, Hisashi Matsuo, Shigeo Kakinoki, Shigeru Takechi, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   77 ( 4 )   926 - 933   2013.4

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    DOI: 10.1253/circj.CJ-13-0115

  • Exercise Intolerance in Chronic Heart Failure - Skeletal Muscle Dysfunction and Potential Therapies Reviewed

    Koichi Okita, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   77 ( 2 )   293 - 300   2013.2

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    DOI: 10.1253/circj.CJ-12-1235

  • Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: Report from the registry data in Japan Reviewed

    Daisuke Goto, Shintaro Kinugawa, Sanae Hamaguchi, Mamoru Sakakibara, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

    JOURNAL OF CARDIOLOGY   61 ( 1-2 )   65 - 70   2013.1

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    DOI: 10.1016/j.jjcc.2012.08.010

  • [Multidisciplinary management for heart failure --prevention, diagnosis and updated treatment]. Reviewed

    Yokoshiki H, Tsutsui H, Goto D, Kinugawa S, Ooka T

    [Hokkaido igaku zasshi] The Hokkaido journal of medical science   88 ( 1 )   11 - 14   2013.1

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    [Multidisciplinary management for heart failure --prevention, diagnosis and updated treatment].

  • Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction Reviewed

    Tadashi Suga, Koichi Okita, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Yokota, Kagami Hirabayashi, Masashige Takahashi, Noriteru Morita, Masahiro Horiuchi, Shintaro Kinugawa, Hiroyuki Tsutsui

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   112 ( 11 )   3915 - 3920   2012.11

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    DOI: 10.1007/s00421-012-2377-x

  • Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice Reviewed

    Mochamad Ali Sobirin, Shintaro Kinugawa, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Putri Azalia, Shingo Takada, Masaru Taniguchi, Toshinori Nakayama, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    CIRCULATION RESEARCH   111 ( 8 )   1037 - +   2012.9

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    DOI: 10.1161/CIRCRESAHA.112.270132

  • Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   76 ( 8 )   1920 - 1927   2012.8

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    DOI: 10.1253/circj.CJ-11-1196

  • Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions Reviewed

    Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Sato, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Noriteru Morita, Masahiro Horiuchi, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF APPLIED PHYSIOLOGY   113 ( 2 )   199 - 205   2012.7

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    DOI: 10.1152/japplphysiol.00149.2012

  • Mode of Death in Patients With Heart Failure and Reduced vs. Preserved Ejection Fraction - Report From the Registry of Hospitalized Heart Failure Patients Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Mochamad Ali Sobirin, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   76 ( 7 )   1662 - 1669   2012.7

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    DOI: 10.1253/circj.CJ-11-1355

  • Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle Reviewed

    Naoki Inoue, Shintaro Kinugawa, Tadashi Suga, Takashi Yokota, Kagami Hirabayashi, Satoshi Kuroda, Koichi Okita, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   302 ( 5 )   H1202 - H1210   2012.3

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    DOI: 10.1152/ajpheart.00534.2011

  • Blood Flow Restriction Exercise in Sprinters and Endurance Runners Reviewed

    Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Noriteru Morita, Masahiro Horiuchi, Tomoyasu Kadoguchi, Masashige Takahashi, Kagami Hirabayashi, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   44 ( 3 )   413 - 419   2012.3

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    DOI: 10.1249/MSS.0b013e31822f39b3

  • High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice Reviewed

    Mayumi Yamato, Takeshi Shiba, Tomomi Ide, Naoko Seri, Wataru Kudo, Makoto Ando, Ken-ichi Yamada, Shintaro Kinugawa, Hiroyuki Tsutsui

    MOLECULAR AND CELLULAR BIOCHEMISTRY   359 ( 1-2 )   161 - 167   2012.1

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    DOI: 10.1007/s11010-011-1010-3

  • Oxidative stress and heart failure Reviewed

    Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   301 ( 6 )   H2181 - H2190   2011.12

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    DOI: 10.1152/ajpheart.00554.2011

  • [Inotropic drug]. Reviewed

    Kinugawa S

    Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 9   397 - 401   2011.11

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    [Inotropic drug].

  • Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   75 ( 10 )   2403 - 2410   2011.10

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    DOI: 10.1253/circj.CJ-11-0267

  • Hyperuricemia predicts adverse outcomes in patients with heart failure Reviewed

    Sanae Hamaguchi, Tomoo Furumoto, Miyuki Tsuchihashi-Makaya, Kazutomo Goto, Daisuke Goto, Takashi Yokota, Shintaro Kinugawa, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   151 ( 2 )   143 - 147   2011.9

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    DOI: 10.1016/j.ijcard.2010.05.002

  • Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome Reviewed

    Takashi Yokota, Shintaro Kinugawa, Koichi Okita, Kagami Hirabayashi, Tadashi Suga, Masaaki Hattori, Yoshinao Nakagawa, Noriko Oyama-Manabe, Hiroki Shirato, Hiroyuki Tsutsui

    HYPERTENSION RESEARCH   34 ( 9 )   1029 - 1034   2011.9

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    DOI: 10.1038/hr.2011.78

  • Sex differences with respect to clinical characteristics, treatment, and long-term outcomes in patients with heart failure Reviewed

    Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Kazutomo Goto, Daisuke Goto, Tomoo Furumoto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    INTERNATIONAL JOURNAL OF CARDIOLOGY   150 ( 3 )   338 - 339   2011.8

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    DOI: 10.1016/j.ijcard.2011.03.042

  • Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure Reviewed

    Yukihiro Ohta, Shintaro Kinugawa, Shouji Matsushima, Taisuke Ono, Mochamad A. Sobirin, Naoki Inoue, Takashi Yokota, Kagami Hirabayashi, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   300 ( 5 )   H1637 - H1644   2011.5

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    DOI: 10.1152/ajpheart.01185.2009

  • Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus Reviewed

    Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima, Takashi Yokota

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   48 ( 1 )   68 - 71   2011.1

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    Language:English  

    DOI: 10.3164/jcbn.11-012FR

  • Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Takashi Yokota, Kazutomo Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   74 ( 12 )   2605 - 2611   2010.12

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    DOI: 10.1253/circj.CJ-10-0599

  • Spironolactone use at discharge was associated with improved survival in hospitalized patients with systolic heart failure Reviewed

    Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Kazutomo Goto, Daisuke Goto, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    AMERICAN HEART JOURNAL   160 ( 6 )   1156 - 1162   2010.12

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    DOI: 10.1016/j.ahj.2010.08.036

  • Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure - Report From MetS-CHF Study Reviewed

    Yutaka Miura, Yoshihiro Fukumoto, Nobuyuki Shiba, Toshiro Miura, Kazunori Shimada, Yoshitaka Iwama, Atsutoshi Takagi, Hidenori Matsusaka, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Masanori Asakura, Shuichi Okamatsu, Hiroyuki Tsutsui, Hiroyuki Daida, Masunori Matsuzaki, Hitonobu Tomoike, Hiroaki Shimokawa

    CIRCULATION JOURNAL   74 ( 12 )   2612 - 2621   2010.12

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    DOI: 10.1253/circj.CJ-10-0677

  • Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation o2 of calf muscle during plantar flexion exercise Reviewed International journal

    Horiuchi M, Okita K, Takada S, Omokawa M, Suga T, Morita N, Hirabayashi K, Yokota T, Kinguawa S, Tsutsui H

    Adv Exp Med Biol   662   531 - 536   2010.10

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  • Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice Reviewed

    Masaaki Hokari, Satoshi Kuroda, Shintaro Kinugawa, Tomomi Ide, Hiroyuki Tsutsui, Yoshinobu Iwasaki

    NEUROPATHOLOGY   30 ( 4 )   401 - 407   2010.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1440-1789.2009.01086.x

  • Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism Reviewed

    Caroline Ojaimi, Shintaro Kinugawa, Fabio A. Recchia, Thomas H. Hintze

    CARDIOVASCULAR DIABETOLOGY   9   43   2010.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-9-43

  • Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival Reviewed

    Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Hisashi Yokoshiki, Sanae Hamaguchi, Takashi Yokota, Daisuke Goto, Kazutomo Goto, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   74 ( 7 )   1364 - 1371   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-09-0993

  • Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction Reviewed

    Tadashi Suga, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Masashi Omokawa, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF APPLIED PHYSIOLOGY   108 ( 6 )   1563 - 1567   2010.6

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    DOI: 10.1152/japplphysiol.00504.2009

  • [Myocardial ischemia and metabolic disorder]. Reviewed

    Yokota T, Kinugawa S, Tsutsui H

    Nihon rinsho. Japanese journal of clinical medicine   68 ( 4 )   621 - 624   2010.4

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    [Myocardial ischemia and metabolic disorder].

  • Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure Reviewed

    Miyuki Tsuchihashi-Makaya, Tomoo Furumoto, Shintaro Kinugawa, Sanae Hamaguchi, Kazutomo Goto, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

    HYPERTENSION RESEARCH   33 ( 3 )   197 - 202   2010.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2009.199

  • Clinical characteristics and outcomes of heart failure with preserved ejection fraction: Lessons from epidemiological studies Reviewed

    Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa

    JOURNAL OF CARDIOLOGY   55 ( 1 )   13 - 22   2010.1

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    DOI: 10.1016/j.jjcc.2009.09.003

  • Effects of Atrial Fibrillation on Long-Term Outcomes in Patients Hospitalized for Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Hisashi Yokoshiki, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   73 ( 11 )   2084 - 2090   2009.11

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    DOI: 10.1253/circj.CJ-09-0316

  • Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Takashi Yokota, Akira Takeshita, Hisashi Yokoshiki, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   73 ( 10 )   1901 - 1908   2009.10

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    DOI: 10.1253/circj.CJ-09-0184

  • Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Hisashi Yokoshiki, Norihiro Kato, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   73 ( 10 )   1893 - 1900   2009.10

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    DOI: 10.1253/circj.CJ-09-0254

  • Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice Reviewed

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Shouji Matsushima, Naoki Inoue, Yukihiro Ohta, Sanae Hamaguchi, Mochamad A. Sobirin, Taisuke Ono, Tadashi Suga, Satoshi Kuroda, Shinya Tanaka, Fumio Terasaki, Koichi Okita, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 3 )   H1069 - H1077   2009.9

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    DOI: 10.1152/ajpheart.00267.2009

  • Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan - Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) - Reviewed

    Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Takashi Yokota, Tomomi Ide, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   73 ( 8 )   1442 - 1447   2009.8

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    DOI: 10.1253/circj.CJ-09-0062

  • Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes Reviewed

    Shouji Matsushima, Shintaro Kinugawa, Takashi Yokota, Naoki Inoue, Yukihiro Ohta, Sanae Hamaguchi, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 1 )   H409 - H416   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.01332.2008

  • Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction Reviewed

    Tadashi Suga, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Tomohiro Takahashi, Masashi Omokawa, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF APPLIED PHYSIOLOGY   106 ( 4 )   1119 - 1124   2009.4

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    DOI: 10.1152/japplphysiol.90368.2008

  • Mitochondrial oxidative stress and dysfunction in myocardial remodelling Reviewed

    Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima

    CARDIOVASCULAR RESEARCH   81 ( 3 )   449 - 456   2009.2

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    Language:English  

    DOI: 10.1093/cvr/cvn280

  • Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin Reviewed

    Mayumi Yamato, Takeshi Shiba, Masayoshi Yoshida, Tomomi Ide, Naoko Seri, Wataru Kudou, Shintaro Kinugawa, Hiroyuki Tsutsui

    FEBS JOURNAL   274 ( 15 )   3855 - 3863   2007.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1742-4658.2007.05914.x

  • Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart Reviewed

    Hiroyuki Tsutsui, Shouji Matsushima, Shintaro Kinugawa, Tomomi Ide, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Sanae Hamaguchi, Kenji Sunagawa

    HYPERTENSION RESEARCH   30 ( 5 )   439 - 449   2007.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1291/hypres.30.439

  • [Diabetic heart disease]. Reviewed

    Kinugawa S

    Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 5   465 - 469   2007.5

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    [Diabetic heart disease].

  • Characteristics and outcomes of patients with heart failure in general practices and hospitals - Japanese cardiac registry of heart failure in general practice (JCARE-GENERAL) Reviewed

    Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

    CIRCULATION JOURNAL   71 ( 4 )   449 - 454   2007.4

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    DOI: 10.1253/circj.71.449

  • [Molecular mechanisms of chronic heart failure]. Reviewed

    Kinugawa S, Tsutsui H

    Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 4   87 - 91   2007.4

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    [Molecular mechanisms of chronic heart failure].

  • [Recovery from circulatory support with long term left ventricular assist device in a 29-year-old woman with fulminant giant cell myocarditis]. Reviewed

    Hirabayashil K, Yamada S, Iwamil K, Kinugawa S, Makita N, Okamotol H, Sugiki H, Murashita T, Nakagawa Y, Tsutsui H

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   96 ( 2 )   335 - 337   2007.2

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    [Recovery from circulatory support with long term left ventricular assist device in a 29-year-old woman with fulminant giant cell myocarditis].

  • Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress Reviewed

    Nobuhiro Suematsu, Caroline Ojaimi, Shintaro Kinugawa, Zipping Wang, Xiaobin Xu, Akos Koller, Fabio A. Recchia, Thomas H. Hintze

    CIRCULATION   115 ( 2 )   255 - 262   2007.1

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    DOI: 10.1161/CIRCULATIONHA.106.652693

  • Clinical characteristics and outcome of hospitalized patients with heart failure in Japan - Rationale and design of Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) Reviewed

    Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

    CIRCULATION JOURNAL   70 ( 12 )   1617 - 1623   2006.12

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    DOI: 10.1253/circj.70.1617

  • Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart Reviewed

    Shouji Matsushima, Shintaro Kinugawa, Tomomi Ide, Hidenori Matsusaka, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Kenji Sunagawa, Hiroyuki Tsutsui

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   291 ( 5 )   H2237 - H2245   2006.11

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    DOI: 10.1152/ajpheart.00427.2006

  • Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction Reviewed

    Hidenori Matsusaka, Shintaro Kinugawa, Tomomi Ide, Shouji Matsushima, Tetsuya Shiomi, Toru Kubota, Kenji Sunagawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   48 ( 3 )   95 - 102   2006.9

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    DOI: 10.1097/01.fjc.0000245405.41317.60

  • Mitochondrial oxidative stress, DNA damage, and heart failure Reviewed

    Hiroyuki Tsutsui, Tomomi Ide, Shintaro Kinugawa

    ANTIOXIDANTS & REDOX SIGNALING   8 ( 9-10 )   1737 - 1744   2006.9

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    Language:English  

    DOI: 10.1089/ars.2006.8.1737

  • Targeted deletion of p53 prevents cardiac rapture after myocardial infarction in mice Reviewed

    H Matsusaka, T Ide, S Matsushima, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

    CARDIOVASCULAR RESEARCH   70 ( 3 )   457 - 465   2006.6

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    DOI: 10.1016/j.cardiores.2006.02.001

  • [Oxidative stress and heart failure]. Reviewed

    Kinugawa S, Tsutsui H

    Nihon rinsho. Japanese journal of clinical medicine   64 ( 5 )   848 - 853   2006.5

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    [Oxidative stress and heart failure].

  • Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice Reviewed

    S Matsushima, T Ide, M Yamato, H Matsusaka, F Hattori, M Ikeuchi, T Kubota, K Sunagawa, Y Hasegawa, T Kurihara, S Oikawa, S Kinugawa, H Tsutsui

    CIRCULATION   113 ( 14 )   1779 - 1786   2006.4

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    DOI: 10.1161/CIRCULATIONAHA.105.582239

  • Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload Reviewed

    H Matsusaka, T Ide, S Matsushima, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

    HYPERTENSION   47 ( 4 )   711 - 717   2006.4

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    DOI: 10.1161/01.HYP.0000208840.30778.00

  • Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype Reviewed

    C Ojaimi, W Li, S Kinugawa, H Post, A Csiszar, P Pacher, G Kaley, TH Hintze

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   289 ( 4 )   H1399 - H1407   2005.10

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    DOI: 10.1152/ajpheart.00170.2005

  • [Ca channel blocker and heart failure]. Reviewed

    Kinugawa S, Tsutsui H

    Clinical calcium   15 ( 10 )   1615 - 1622   2005.10

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    [Ca channel blocker and heart failure].

  • gp91(phox)-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II Reviewed

    S Kinugawa, JH Zhang, E Messina, E Walsh, H Huang, PM Kaminski, MS Wolin, TH Hintze

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   289 ( 2 )   H862 - H867   2005.8

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    DOI: 10.1152/ajpheart.00076.2005

  • Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice - Roles of superoxide anion and nitric oxide Reviewed

    S Kinugawa, ZP Wang, PM Kaminski, MS Wolin, JG Edwards, G Kaley, TH Hintze

    CIRCULATION   111 ( 12 )   1480 - 1486   2005.3

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    DOI: 10.1161/01.CIR.0000159261.11520.63

  • A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase Reviewed

    S Kinugawa, H Huang, ZP Wang, PM Kaminski, MS Wolin, TH Hintze

    CIRCULATION RESEARCH   96 ( 3 )   355 - 362   2005.2

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    DOI: 10.1161/01.RES.0000155331.09458.A7

  • Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes - The role of angiotensin II type 1 receptor and NAD(P)H oxidase Reviewed

    S Kinugawa, H Post, PM Kaminski, XP Zhang, XB Xu, H Huang, FA Recchia, M Ochoa, MS Wolin, G Kaley, TH Hintze

    CIRCULATION   108 ( 23 )   2934 - 2940   2003.12

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    DOI: 10.1161/01.CIR.0000096488.78151.97

  • Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction Reviewed

    S Hayashidani, H Tsutsui, T Shiomi, N Suematsu, S Kinugawa, T Ide, J Wen, A Takeshita

    CIRCULATION   105 ( 7 )   868 - 873   2002.2

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    DOI: 10.1161/hc0702.104164

  • Effects of ACE inhibition on left ventricular failure and oxidative stress in Dahl salt-sensitive rats Reviewed International journal

    Tsutsui H, Ide T, Hayashidani S, Kinugawa S, Suematsu N, Utsumi H, Takeshita A

    J Cardiovasc Pharmacol   37 ( 6 )   725 - 733   2001.6

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  • Alpha1-Adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts Reviewed International journal

    Suematsu N, Satoh S, Kinugawa S, Tsutsui H, Hayashidani S, Nakamura R, Egashira K, Makino N, Takeshita A

    Am J Physiol Heart Circ Physiol   281 ( 2 )   637 - 646   2001.6

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  • Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes Reviewed International journal

    Tsutsui H, Kinugawa S, Ide T, Hayashidani S, Suematsu N, Satoh S, Nakamura R, Egashira K, Takeshita A

    J Cardiovasc Pharmacol   37 ( 1 )   16 - 24   2001.1

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  • Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress Reviewed International journal

    Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, Utsumi H, Takeshita A

    Circ Res   87 ( 5 )   392 - 398   2000.2

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  • Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium Reviewed International journal

    Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A

    Circ Res   86 ( 2 )   152 - 157   2000.1

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  • Adrenoceptor-mediated regulation of myofibrillar Ca2+ sensitivity through the GTP-binding protein-related mechanisms: tension recording in beta-escin-skinned single rat cardiac cells with preserved receptor functions Reviewed International journal

    Satoh S, Kinugawa S, Tsutsui H, Takeshita A

    Pflugers Arch-Eur J Physiol   437 ( 5 )   702 - 709   1999.5

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  • Endocardial versus epicardial differences of sarcoplasmic reticulum Ca2+-ATPase gene expression in the canine failing myocardium Reviewed International journal

    Igarashi-Saito K, Tsutsui H, Takahashi M, Kinugawa S, Egashira K, Takeshita A

    Basic Res Cardiol   94 ( 4 )   267 - 273   1999.4

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  • Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action Reviewed International journal

    Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A

    Circulation   100 ( 7 )   690 - 692   1999.3

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  • Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocytes contractile dysfunction in heart failure Reviewed International journal

    Kinugawa S, Tsutsui H, Satoh S, Takahashi M, Ide T, Igarashi-Saito K, Arimura K, Egashira K, Takeshita A

    Cardiovasc Res   44 ( 2 )   398 - 406   1999.2

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  • Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes Reviewed International journal

    9. Kinugawa S, Tsutsui H, Ide T, Nakamura R, Arimura K, Egashira K, Takeshita A

    Cardiovasc Res   43 ( 1 )   157 - 164   1999.1

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  • Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium Reviewed International journal

    Ide T, Tsutsui H, Kinugawa S, Ustumi H, Kang D, Hattori N, Uchida K, Arimura K, Egashira K, Takeshita A

    Circ Res   85 ( 4 )   357 - 363   1999.1

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  • Role of SR Ca2+-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure Reviewed

    K Igarashi-Saito, H Tsutsui, S Yamamoto, M Takahashi, S Kinugawa, H Tagawa, M Usui, M Yamamoto, K Egashira, A Takeshita

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   275 ( 1 )   H31 - H40   1998.7

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  • Role of microtubles in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy Reviewed International journal

    Takahashi M, Tsutsui H, Kinugawa S, Igarashi-Saito K, Yamamoto S, Yamamoto M, Tagawa H, Imanaka-Yoshida K, Egashira K, Takeshita A

    J Mol Cell Cardiol   30 ( 5 )   1047 - 1057   1998.5

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  • Negative inotropic effect of basic fibroblast growth factor on adult rat cardiac myocytes Reviewed International journal

    Ishibashi Y, Urabe Y, Tsutsui H, Kinugawa S, Sugimachi M, Takahashi M, Yamamoto S, Tagawa H, Sunagawa K, Takeshita A

    Circulation   96 ( 8 )   2501 - 2504   1997.2

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    Language:Japanese   Book type:Scholarly book

  • 心不全 1.心不全の病態分類、原因疾患、病態 包括的心臓リハビリテーション(後藤葉一編)

    絹川真太郎( Role: Sole author)

    南江堂  2022.6 

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    Language:Japanese   Book type:Scholarly book

  • 心不全の治療 1.薬物治療 心不全療養指導士認定試験ガイドブック(改訂第2版)(日本循環器学会編)

    絹川真太郎( Role: Joint author)

    南江堂  2022.4 

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    Language:Japanese   Book type:Scholarly book

  • 心不全治療薬(強心薬)Pocket Drugs 2022(福井次矢監修,小松康弘,渡邊裕司編)

    絹川真太郎、筒井裕之( Role: Joint author)

    2022.1 

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    Language:Japanese   Book type:Scholarly book

  • HFrEF患者の薬物療法 一からわかる循環器腎臓病学(伊藤浩編)

    絹川真太郎、筒井裕之( Role: Joint author)

    文光堂  2021.4 

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    Language:Japanese  

  • 利尿薬(経口) ザ・ベーシックメソッド 心不全 薬物療法(筒井裕之編)

    絹川真太郎( Role: Joint author)

    メジカルビュー社  2021.4 

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    Language:Japanese  

  • 高齢者HFpEF患者の臨床的特徴とどのように診断するかに関して教えてください 高齢者の循環器診療Q&A(伊藤浩編)

    絹川真太郎、筒井裕之( Role: Joint author)

    文光堂  2021.3 

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    Language:Japanese  

  • フレイルとその予防 心不全診療アップグレード(佐藤幸人編)

    絹川真太郎( Role: Joint author)

    日本医事新報社  2021.3 

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  • 心不全治療薬(強心薬)Pocket Drugs 2021(福井次矢監修,小松康弘,渡邊裕司編)

    絹川真太郎、筒井裕之

    医学書院  2021.1 

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    Language:Japanese  

  • 心不全の治療 1.薬物治療 心不全療養指導士認定試験ガイドブック(日本循環器学会編)

    絹川真太郎( Role: Joint author)

    南江堂  2020.7 

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    Language:Japanese   Book type:Scholarly book

  • Comprehensive Cardiac Rehabilitation: Update of Non-Pharmacological Therapy for Heart Failure.

    Kinugawa S( Role: Joint author)

    2020.4 

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    Language:English   Book type:Scholarly book

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Presentations

  • 心不全 Invited

    絹川真太郎

    専門薬剤師認定取得のための薬物療法集中講義  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB   Country:Japan  

  • 心不全における交感神経活性と運動療法 Invited

    絹川真太郎、松島将士、篠原啓介、池田翔大

    日本心不全学会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 心不全における新規栄養療法 Invited

    髙田真吾、絹川真太郎

    心臓リハビリテーション学会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 心不全の骨格筋異常-マイオカインの役割 Invited

    絹川真太郎、髙田真吾、麓佳月

    日本心臓リハビリテーション学会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • サルコペニア予防を目指した心不全治療 Invited

    絹川真太郎

    日本心臓リハビリテーション学会北陸地方会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢市   Country:Japan  

  • 心不全における骨格筋エネルギー代謝異常 Invited

    絹川真太郎

    日本心不全学会学術集会  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:奈良市   Country:Japan  

  • 心不全治療の最新トピックスと当院での取り組み Invited

    絹川真太郎

    日本心不全学会学術集会  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:奈良市   Country:Japan  

  • Skeletal muscle abnormalities and myokines in heart failure Invited

    2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 心不全患者における食事歴法質問票における栄養評価 Invited

    絹川真太郎、横田卓

    日本病態栄養学会年次集会  2022.1 

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    Event date: 2022.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 心不全に対する心臓リハビリテーション Invited

    絹川真太郎

    日本循環器学会九州地方会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 不全心筋におけるミトコンドリア代謝リプログラミング

    高田真吾、佐邊壽孝、絹川真太郎

    日本生化学学会大会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • マイオカインとミトコンドリア:加齢や疾患における摂動

    絹川真太郎、高田真吾、佐邊壽孝

    日本生化学学会大会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 心不全治療アルゴリズム Invited

    絹川真太郎

    日本心不全学会学術集会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 心不全治療アップデート-新規治療法の位置づけ- Invited

    絹川真太郎

    日本心臓学会学術集会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 心疾患の超急性期における骨格筋異常発症機序 Invited

    高田真吾、絹川真太郎

    日本心臓リハビリテーション学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 高齢心疾患患者に対する心臓リハビリテーションのエビデンス Invited

    絹川真太郎

    日本心臓リハビリテーション学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 心不全と骨格筋の基礎 Invited

    絹川真太郎

    日本心臓リハビリテーション学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese  

    Country:Japan  

  • Treatment with brain-derived neurotrophic factor (BDNF) for skeletal muscle abnormalities in heart failure Invited

    2021.3 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Skeletal muscle abnormalities in heart failure Invited International conference

    Kinugawa Shintaro

    Asian Pacific Society of Cardiology Japan Circulation Society 2020  2020.3 

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    Event date: 2021.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳由来神経栄養因子による心不全骨格筋李朝 Invited

    高田真吾、絹川真太郎

    日本心臓リハビリテーション学会学術集会  2020.7 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Skeletal muscle as a therapeutic target Invited

    Kinugawa Shintaro

    2020.7 

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    Event date: 2021.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 運動療法代替治療法の開発 Invited

    絹川真太郎

    日本臨床運動療法学会学術集会  2020.9 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Inadequate Nutritinal Intake is an Independent Predictor of Poor Outcomes in Patients with Heart Failure Invited

    2019.3 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ステージA、Bの運動療法の効果と実際 Invited

    絹川真太郎

    日本心不全学会学術集会  2019.10 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 心不全におけるマイオカインの役割 Invited

    絹川真太郎

    日本心臓病学会学術集会  2019.9 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 心不全の骨格筋異常におけるキサンチンオキシダーゼ由来活性酸素種の役割 Invited

    絹川真太郎、南部秀雄、高田真吾

    日本酸化ストレス学会学術集会  2019.6 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

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MISC

  • 高齢心不全患者に対する心臓リハビリテーションのエビデンス

    絹川真太郎

    日本心臓リハビリテーション学会誌   2023.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Ergogenic effects of caffeine are mediated by myokines. Reviewed

    Takada S, Fumoto Y, Kinugawa S

    2022.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 心不全

    絹川真太郎

    日本臨床   2022.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases. Reviewed

    Takada S, Kinugawa S, Handa H, Yokota T, Sabe H

    Front Oncol   2022.10

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 心不全患者の運動療法とマイオカイン

    絹川真太郎

    2022.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Treatment for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies Reviewed

    Takada S, Sabe H, Kinugawa S

    Am J Physiol Heart Circ Physiol   2022.2

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  • 押さえておくべき心不全診療ガイドラインのポイント

    絹川真太郎

    2021.10

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  • 高齢者心不全の心臓リハビリテーション

    絹川真太郎

    2021.10

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    Repository Public URL: https://hdl.handle.net/2324/7172593

  • 骨格筋異常

    絹川真太郎

    日本臨床   2021.8

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  • 治療アルゴリズムの中での従来の心不全治療薬と新規薬剤の位置づけ

    絹川真太郎

    2021.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 心筋症

    絹川真太郎

    内科   2021.4

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  • 心臓サルコイドーシス

    絹川真太郎

    内科   2021.4

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  • 急性心膜炎

    絹川真太郎

    日本医事新報   2020.10

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  • 心不全パンデミックを防ぐためにはバイオマーカーをどう使うか?

    絹川真太郎、筒井裕之

    2020.10

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  • 運動療法を理解するための運動生理

    絹川真太郎

    診断と治療   2020.6

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  • ステージCの心臓リハビリテーション

    絹川真太郎

    2020.6

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  • Abnormalities of skeletal muscle, adipocyte tissue, and lipid metabolism in heart failure: practical therapeutic targets Reviewed

    Takada S, Sabe H, Kinugawa S

    Front Cardiovasc Med   2020.5

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  • 循環不全や呼吸不全による臓器不全へ至るメカニズムとは?

    絹川真太郎

    2020.4

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  • 糖尿病と心不全に共通する骨格筋異常

    絹川真太郎

    糖尿病プラクティス   2020.2

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  • Empagliflozin Restores Lowered Exercise Endurance Capacity via the Activation of Skeletal Muscle Fatty Acid Oxidation in Murine Heart Failure

    Hideo Nambu, Shingo Takada, Satoshi Maekawa, Naoya Kakutani, Takaaki Furihata, Akimichi Saito, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa

    CIRCULATION   2019.11

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  • 重複障害を有する超高齢心疾患患者に対するリハビリテーションの工夫 難渋重症例をどのように対応するか? 後期高齢心不全患者に対する急性期離床プログラムの開発と運用

    角谷 尚哉, 吉田 一郎, 福島 新, 中村 梨沙子, 塚田 貴紀, 絹川 真太郎, 安斉 俊久

    日本循環器学会学術集会抄録集   2019.3

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  • 在宅でのICTを活用した心不全患者向けセルフケア強化システムの開発・検証

    髙田 真吾, 絹川 真太郎, 横田 卓

    福田記念医療技術振興財団情報   2018.12

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    Language:Japanese  

  • Excessive Mitochondrial Reactive Oxygen Species Emission From Circulating Blood Cells is Associated With Systemic Oxidative Stress, Severity of Heart Failure, and Exercise Intolerance

    Ryosuke Shirakawa, Takashi Yokota, Takayuki Nakajima, Shingo Takada, Miwako Yamane, Akimichi Saito, Satoshi Maekawa, Naoya Kakutani, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takashi Katayama, Hideo Nambu, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Arata Fukushima, Shintaro Kinugawa, Toshihisa Anzai

    CIRCULATION   2018.11

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  • The Outer Mitochondrial Membrane Protein, mitoNEET, Sustains Structure of Mitochondrial Cristae

    Takaaki Furihata, Shintaro Kinugawa, Shingo Takada, Satoshi Maekawa, Takashi Katayama, Ryosuke Shirakawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Naoya Kakutani, Akimichi Saito, Arata Fukushima, Takashi Yokota, Toshihisa Anzai

    CIRCULATION   2018.11

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  • Inhibition of Xanthine Oxidase in the Acute Phase Preserves Mitochondrial Function in Skeletal Muscle and Exercise Capacity in Heart Failure After Myocardial Infarction

    Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Ryosuke Shirakawa, Takashi Katayama, Katsuma Yamanashi, Yoshikuni Obata, Takaaki Furihata, Akimichi Saito, Takashi Yokota, Shintaro Kinugawa, Toshihisa Anzai

    CIRCULATION   2018.11

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  • 加齢に伴う運動能力低下・サルコペニアのバイオマーカーとしての血中アドロピンの臨床応用と基礎的検討

    福島 新, 絹川 真太郎, 横田 卓, 高田 真吾, 沖田 孝一

    デサントスポーツ科学   2018.5

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    Language:Japanese  

  • Coronary Artery Stenosis is Associated With Mitochondrial Dysfunction in Epicardial Adipose Tissue

    Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihara, Shuhei Miura, Shingo Takada, Ryosuke Shirakawa, Takaaki Furihata, Masaya Tsuda, Junichi Matsumoto, Takashi Katayama, Arata Fukushima, Akimichi Saito, Yoshiro Matsui, Shintaro Kinugawa

    CIRCULATION   2017.11

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  • High Respiratory Exchange Ratio at Submaximal Exercise Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure

    Naoya Kakutani, Arata Fukushima, Takashi Yokota, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Takahiro Abe, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Shingo Takada, Akimichi Saito, Koichi Okita, Shintaro Kinugawa

    CIRCULATION   2017.11

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  • Cardiac Hypertrophy in Congenital Heart Disease Delays the Maturation of Cardiac Fatty Acid B-Oxidation by Modifying Myocardial Acetylation Control(和訳中)

    福島 新, 絹川 真太郎, 横田 卓, 齋藤 晶理, 高田 真吾, 降旗 高明, 松本 純一, 津田 正哉, 中島 孝之, 片山 貴史, 前川 聡, 南部 秀雄, 角谷 尚哉, 白川 亮介, 沖田 孝一, ポール・カンター, アイバン・レベッカ, ギャリー・ロパスチュック

    日本循環器学会学術集会抄録集   2017.3

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  • The Novel Heart-specific RING-finger Protein 207 Modulates Energy Metabolism in Cardiomyocytes(和訳中)

    高田 真吾, 水島 航, 降旗 高明, 松本 純一, 津田 正哉, 片山 貴史, 中島 孝之, 福島 新, 横田 卓, 絹川 真太郎

    日本循環器学会学術集会抄録集   2017.3

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  • Skeletal Muscle Mitochondrial Protein Hyperacetylation Contributes to Exercise Intolerance in a Murine Model of Heart Failure After Myocardial Infarction(和訳中)

    津田 正哉, 高田 真吾, 福島 新, 水島 航, 降旗 高明, 松本 純一, 片山 貴史, 中島 孝之, 白川 亮介, 前川 聡, 南部 秀雄, 角谷 尚哉, 横田 卓, 絹川 真太郎

    日本循環器学会学術集会抄録集   2017.3

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  • Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis(和訳中)

    中島 孝之, 横田 卓, 新宮 康栄, 山田 陽, 伊庭 裕, 若狭 哲, 大岡 智学, 高田 真吾, 白川 亮介, 降旗 高明, 津田 正哉, 松本 純一, 片山 貴史, 福島 新, 松居 喜郎, 絹川 真太郎

    日本循環器学会学術集会抄録集   2017.3

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  • 【基礎研究を予防心臓病学の未来に活かす】 心不全における骨格筋萎縮予防

    沖田 孝一, 高田 真吾, 横田 卓, 絹川 真太郎

    心臓リハビリテーション   2017.1

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  • 循環器領域における骨格筋の役割 心不全における骨格筋異常をターゲットとした治療法の開発

    絹川 真太郎, 福島 新, 高田 真吾, 松本 純一

    血管   2017.1

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  • Brain-derived Neurotrophic Factor Plays an Important Role of Exercise Capacity and Mitochondrial Function in the Skeletal Muscle in Mice With Post-infarct Heart Failure

    Takayuki Nakajima, Shintaro Kinugawa, Junichi Matsumoto, Shingo Takada, Takaaki Furihata, Masaya Tsuda, Takashi Katayama, Hideo Nanbu, Ryosuke Shirakawa, Satoshi Maekawa, Naoya Kakutani, Wataru Mizushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2016.11

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  • The Activation of Glucagon-Like Peptide-1 Improves the Mitochondrial Abnormalities in Skeletal Muscle and Exercise Intolerance in Heart Failure Mice

    Takashi Katayama, Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takayuki Nakajima, Masaya Tsuda, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2016.11

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  • Mitochondrial Protein Acetylation in Skeletal Muscle Was Associated With Exercise Intolerance in Heart Failure After Myocardial Infarction in Mice

    Masaya Tsuda, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Takashi Yokota, Wataru Mizushima, Takaaki Furihata, Junichi Matsumoto, Takashi Katayama, Takayuki Nakajima, Satoshi Maekawa, Hideo Nambu, Ryosuke Shirakawa, Naoya Kakutani, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2016.11

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  • A Multi-Center Observational Study of Dilated Phase of Hypertrophic Cardiomyopathy

    Shouji Matsushima, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • 心不全における多臓器不全 心不全における骨格筋異常 マイオカインの役割

    絹川 真太郎, 松本 純一, 高田 真吾

    日本心臓病学会学術集会抄録   2016.9

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  • The Activation of Glucagon-Like Peptide-1 Improves the Mitochondrial Abnormalities in Skeletal Muscle and Exercise Intolerance in Heart Failure Mice

    Takashi Katayama, Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Plasma Acetyl-lysine is a Novel Marker for Exercise Capacity in Patients With Heart Failure

    Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Takashi Yokota, Takaald Furihata, Junichi Matsumoto, Takashi Katayama, Takayuki Nakajima, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Pioglitazone Improves Aerobic Capacity and Skeletal Muscle Energy Metabolism in Patients with Metabolic Syndrome

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Nutritional Assessment in Patients with Heart Failure and Exercise Intolerance -Comparative Analysis of GNRI, MNA, and CONUT-

    Takeshi Sota, Yoshiharu Kinugasa, Hiroko Kamitani, Natsuko Nakayama, Miyuki Makaya, Shintaro Kinugawa, Takahiro Naruse, Masahiko Kato, Hiroshi Hagino, Kazuhiro Yamamoto

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Nifedipine Negatively Regulates Nox4 and Inhibits HDAC4 Oxidation in Phenylephrine-Induced Cardiac Hypertrophy

    Shouji Matsushima, Junichi Matsumoto, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • NADPH Oxidase 4 is a Major Source of Mitochondrial Reactive Oxygen Species in the Heart

    Shouji Matsushima, Shintaro Kinugawa, Junichi Sadoshima, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • HeartMate IIから離脱し得た拡張型心筋症の一症例

    表和徳, 榊原守, 高橋雅之, 浅川直也, 野口圭士, 徳田裕輔, 神谷究, 松島将士, 絹川真太郎, 大岡智学, 松居喜郎, 筒井裕之

    日本循環器学会北海道地方会(Web)   2016.9

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  • Development of Novel Therapeutic Strategy for Heart Failure via Activating Invariant Natural Killer T Cells

    Naoki Ishimori, Akimichi Saito, Shintaro Kinugawa, Wataru Mizushima, Ryousuke Shirakawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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    DOI: 10.1016/j.cardfail.2016.07.041

  • Comparative Analysis of Ability to Assess Nutritional Status between CONUT and GNRI in Patients with Heart Failure

    Hiroko Kamitani, Yoshiharu Kinugasa, Takeshi Sota, Natsuko Nakayama, Miyuki Makaya, Shintaro Kinugawa, Takahiro Naruse, Masahiko Kato, Hiroshi Hagino, Kazuhiro Yamamoto

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Cardiac Hypertrophy in Neonates With Congenital Heart Disease Delays Maturational Alterations in Cardiac Energy Metabolism by Modifying Myocardial Acetylation Control

    Arata Fukushima, Alda Huqi, Liyan Zhang, Victoria H. Lam, Tariq Altamimi, Shintaro Kinugawa, Hiroyuki Tsutsui, Ivan M. Rebeyka, Paul F. Kantor, Gary D. Lopaschuk

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Brain-Derived Neurotrophic Factor Regulates Exercise Capacity and Mitochondria' Function in the Skeletal Muscle in Mice with Post-Infarct Heart Failure

    Junichi Matsumoto, Shingo Takada, Shintaro Kinugawa, Takaaki Furihata, Masaya Tsuda, Takayuki Nakajima, Takashi Katayama, Wataru Mizushima, Takashi Yokota, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Association of Helicobacter Pylori with Chronic Heart Failure

    Shouji Matsushima, Masaya Tsuda, Junichi Matsumoto, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Analysis of Expired Gas During the Hemodialysis in Patients With Cardiovascular Disease

    Motoki Nakao, Masashige Takahashi, Kou Motoi, Hikaru Hagiwara, Yoshikuni Obata, Hidetsugu Sakai, Shintaro Kinugawa, Koichi Okita

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Acetylation Control Contributes to Maturational Alterations in Cardiac Energy Metabolism in the Newborn Heart

    Arata Fukushima, Osama A. Alrob, Liyan Zhang, Cory S. Wage, Tariq Altamimi, Shintaro Kinugawa, Hiroyuki Tsutsui, Ivan M. Rebeyka, Paul F. Kantor, Gary D. Lopaschuk

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Alpha-galactosylceramide-pulsed human dendritic cells can ameliorate post-infarct cardiac remodeling and failure in mice

    A. Saito, N. Ishimori, M. Nishikawa, Y. Masaki, S. Kinugawa, H. Tsutsui

    EUROPEAN HEART JOURNAL   2016.8

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  • Brain-derived neurotrophic factor improves exercise capacity and mitochondrial function in the skeletal muscle in mice with post-infarct heart failure

    J. Matsumoto, S. Takada, S. Kinugawa, W. Mizushima, T. Furihata, M. Tsuda, T. Nakajima, T. Katayama, T. Yokota, K. Okita, H. Tsutsui

    EUROPEAN HEART JOURNAL   2016.8

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  • 維持期慢性心不全患者の良好な栄養状態には食事パターンが影響する 栄養疫学研究から

    池田 陽子, 絹川 真太郎, 眞茅 みゆき

    日本静脈経腸栄養学会雑誌   2016.1

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  • 心不全モデルマウスにおける骨格筋ミトコンドリア機能低下に対する脳由来神経栄養因子の役割解明

    高田 真吾, 絹川 真太郎, 横田 卓, 松島 将士, 沖田 孝一, 筒井 裕之

    体力科学   2015.12

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  • 酸化ストレスの抑制はアンジオテンシンII誘発性の骨格筋萎縮を改善する

    門口 智泰, 絹川 真太郎, 高田 真吾, 田中 寿人, 沖田 孝一, 筒井 裕之

    体力科学   2015.12

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  • 心臓リハビリテーション すべてわかるWhy~Howから最先端 サルコペニア、フレイル、マイオカインとは?

    高田 真吾, 絹川 真太郎, 沖田 孝一, 筒井 裕之

    日本冠疾患学会雑誌   2015.11

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  • Brain-Derived Neurotrophic Factor Could Regulate Mitochondrial Function in the Skeletal Muscle Through Ampk-Pgc1 alpha Signaling in Heart Failure Mice

    Takayuki Nakajima, Shintaro Kinugawa, Shingo Takada, Junichi Matsumoto, Wataru Misushima, Takaaki Furihata, Masaya Tsuda, Takashi Yokota, Shouji Matsushima, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2015.10

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  • 血流制限を併用したレジスタンス運動が血管機能へ影響

    沖田 孝一, 高田 真吾, 門口 智泰, 森田 憲輝, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

    北翔大学北方圏生涯スポーツ研究センター年報   2015.10

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    従来の高強度負荷を用いるレジスタンス運動では、血管機能を悪化させるとの報告が散見される。近年、血流制限を併用したレジスタンス運動が、低強度負荷にもかかわらず、顕著な筋肥大および筋力増加をもたらすことが報告された。しかしながら、同運動が血管機能にどのような影響を及ぼすのかは明確にされていない。本研究では、血流制限を併用した低強度レジスタンス運動が筋量・筋力および血管機能に与える影響について検討した。健常男性14名にて、右下腿を対象に、最大挙上重量(1RM)の20%を用いた血流制限下仰臥位足関節底屈運動を、60収縮(30回/分、2分間)を2セット、1日2回、週3回、4週間実施した。血流制限は、右大腿部に空気圧式カフを装着し、安静時収縮期血圧の1.3倍にて施行した。トレーニング前後、血管機能の指標として、CAVI(心臓足首血管指数)、四肢血圧をそれぞれ、フクダ電子社製脈波検査装置(VaSera:VS-1000)により、また、1RMおよび最大筋横断面積(MCA)を測定した。トレーニング後、1RMおよびMCAは有意に増加した(p<0.05)。血圧値は対象肢の収縮期血圧においてのみ有意に低下した(p<0.05)。CAVI値はいずれの側においても変化が認められなかった。血流制限を併用した低強度レジスタンス運動は、筋量および筋力を増加させるとともに、血管機能を改善する可能性が示唆された。(著者抄録)

  • Metabolomic Analysis Reveals New Insights Towards Understanding Skeletal Muscle Mass and Exercise Capacity in Patients with Heart Failure

    Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Takashi Yokota, Shoji Matsushima, Takaaki Furihata, Junichi Matsumoto, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2015.10

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  • ナチュラルキラーT細胞活性化による新たな心不全治療法の開発

    筒井裕之, 絹川真太郎, 石森直樹, 佐藤典宏, 本橋新一郎

    先進医薬研究振興財団 2014年度 研究成果報告集   2015.3

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  • 精神及び身体機能高度低下例における複合的音楽療法の可能性

    沖田 孝一, 森田 憲輝, 高田 真吾, 舛谷 夕貴, 絹川 真太郎, 佐々木 浩子, 澤田 悦子

    心臓リハビリテーション   2015.3

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    "Exercise is medicine"に象徴されるように、運動療法を主軸とした心臓リハビリテーションは、疾患治療ツールとして発展してきた。しかしながら、超高齢化が進む臨床現場では、歩行すら困難な患者が増加しており、運動療法の限界が懸念される。身体負荷が少ない音楽療法などの芸術療法は、特にうつ状態や認知機能の改善を目的として民間療法的に施行されているが、ターゲットとする精神・神経機能への効果を客観的に評価することが難しく、科学エビデンスに乏しいため、医療には組み込まれていない。一方、精神・神経機能は、心疾患者の予後に影響することはよく知られている。脳由来神経栄養因子(BDNF)は、神経細胞の寿命、成長、維持に中心的な役割をしており、その血中レベルが、学習、記憶、認知機能やうつ、さらには狭心症患者の予後に関連することが報告されている。そこで我々は、身体機能が著しく低下した高齢者において、血中BDNFを精神・神経機能のバイオマーカーとして用い、歌唱、簡易楽器の演奏からなる複合的な音楽療法の効果を検討し、良好な結果を得たので、心リハ領域における音楽療法の潜在的有用性について報告する。(著者抄録)

  • 心不全における水管理

    絹川 真太郎, 筒井 裕之

    循環器内科   2015.1

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  • アンジオテンシンII受容体阻害薬はストレプトゾトシン誘発性糖尿病マウスにおける運動能力低下と骨格筋代謝障害を改善する

    菅 唯志, 絹川 真太郎, 高田 真吾, 門口 智泰, 筒井 裕之

    体力科学   2014.12

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  • レニン・アンジオテンシン系の活性化は骨格筋異常を介して運動能力低下を引き起こす

    門口 智泰, 絹川 真太郎, 高田 真吾, 菅 唯志, 田中 寿人, 沖田 孝一, 筒井 裕之

    体力科学   2014.12

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  • 心筋梗塞後心不全における骨格筋ミトコンドリア機能および運動能力に対するDPP-4阻害薬の効果

    高田 真吾, 絹川 真太郎, 正木 芳宏, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

    体力科学   2014.12

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  • AST-120 Ameliorates Lowered Exercise Capacity and Mitochondrial Dysfunction of the Skeletal Muscle in Mice with Chronic Kidney Disease via Reducing Oxidative Stress

    Mikito Nishikawa, Naoki Ishimori, Shingo Takada, Akimichi Saito, Tomoyasu Kadoguchi, Takaaki Furihata, Arata Fukushima, Shouji Matsushima, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Influence of Nutritional Status on Depressive Symptoms and Quality of Life in Patients With Heart Failure

    Miyuki Tsuchihashi-Makaya, Arata Fukushima, Shintaro Kinugawa, Yoshiharu Kinugasa, Taisuke Ono, Hisashi Matsuo, Akiko Okada, Masahiko Kato, Kazuhiro Yamamoto, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Impact of Health Literacy on Long-Term Outcomes in Patients with Heart Failure

    Miyuki Tsuchihashi-Makaya, Shiho Matsuoka, Takahiro Kayane, Masako Koizumi, Michiyo Yamada, Akiko Okada, Miyuki Yazawa, Shintaro Kinugawa

    CIRCULATION   2014.11

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  • Fyn is a Sensor and Regulator of Nox4-derived ROS in the Heart

    Shoji Matsushima, Junya Kuroda, Peiyong Zhai, Tong Liu, Hong Li, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

    CIRCULATION   2014.11

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  • Disruption of Outer Mitochondrial Membrane Protein, MitoNEET, Increases Mitochondrial Iron Content in the Heart

    Takaaki Furihata, Shintaro Kinugawa, Shouji Matsushima, Shingo Takada, Arata Fukushima, Wataru Mizushima, Tomoyasu Kadoguchi, Yoshihiro Masaki, Takashi Yokota, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Circulating Invariant Natural Killer T Cells are Decreased in Patients With Chronic Heart Failure

    Akimichi Saito, Naoki Ishimori, Mikito Nishikawa, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Changes of Metabolomic Profiling Are Associated With Reduced Exercise Capacity in Patients With Heart Failure

    Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shoji Matsushima, Takaaki Furihata, Shingo Takada, Tomoyasu Kadoguchi, Masato Kudo, Junichi Matsumoto, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Brain-Derived Neurotrophic Factor Maintains Exercise Capacity and Mitochondrial Function in the Skeletal Muscle Through Ampk-Pgc1 alpha Signaling

    Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Wataru Mizushima, Arata Fukushima, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Tadashi Suga, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Angiotensin II Directly Induces Mitochondrial Dysfunction and Atrophy in the Skeletal Muscle

    Tomoyasu Kadoguchi, Shintaro Kinugawa, Arata Fukushima, Takaaki Furihata, Tadashi Suga, Shingo Takada, Wataru Mizushima, Masato Kudo, Junichi Matsumoto, Masaya Tsuda, Mikito Nishikawa, Takashi Yokota, Shoji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2014.11

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  • Angiotensin II Could Directly Induced Mitochondrial Dysfunction and Atrophy in the Skeletal Muscle

    Tomoyasu Kadoguchi, Shintaro Kinugawa, Arata Fukushima, Takaaki Furihata, Shingo Takada, Takashi Yokota, Shoji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2014.10

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  • Nifedipine Attenuates Cardiac Hypertrophy by Inhibiting Nox4-induced Oxidation of HDAC4

    Junichi Matsumoto, Shouji Matsushima, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

    JOURNAL OF CARDIAC FAILURE   2014.10

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  • Circulating Invariant Natural Killer T Cells are Decreased in Patients With Chronic Heart Failure

    Akimichi Saito, Naoki Ishimori, Mikito Nishikawa, Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2014.10

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  • Changes of Metabolomic Profiling are Associated with Reduced Exercise Capacity in Patients with Heart Failure

    Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shoji Matsushima, Takaaki Furihata, Shingo Takada, Masato Kudo, Junichi Matsumoto, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2014.10

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  • Sesamin improves lowered exercise capacity and mitochondrial dysfunction in the skeletal muscle from high fat diet-induced diabetic mice

    S. Takada, S. Kinugawa, D. Takemoto, T. Kadoguchi, T. Yokota, S. Matsushima, A. Fukushima, Y. Masaki, T. Furihata, T. Suga, W. Mizushima, Y. Ono, H. Shibata, K. Okita, H. Tsutsui

    DIABETOLOGIA   2014.9

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  • 北海道における心臓移植報告

    大岡 智学, 新宮 康栄, 若狭 哲, 松居 喜郎, 榊原 守, 絹川 真太郎, 筒井 裕之, 小林 真梨子, 久保田 卓, 杉木 宏司

    日本移植学会総会プログラム抄録集   2014.8

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  • Dipeptidyl Peptidase-4 Inhibitor Improved Exercise Capacity in Association with Switching to Oxidative Skeletal Muscle Fiber Type in Mice with Post-infarct Heart Failure

    Yoshihiro Masaki, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Takaaki Furihata, Ryoichi Katsuyama, Tadashi Suga, Masashige Takahashi, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

    DIABETES   2014.6

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  • 北海道大学における植込型補助人工心臓治療及び心臓移植実施体制の現状

    大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 絹川 真太郎, 榊原 守, 筒井 裕之, 小林 真梨子, 浅野 恵子, 寒河江 磨, 法邑 まなみ, 矢萩 亮児, 加藤 伸彦

    移植   2014.5

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  • 第18回欧州スポーツ医学会2013年6月26-29日バルセロナ、スペインにおける発表 レジスタンス運動における血流制限のタイミングの影響(18th Annual Congress of European College of Sports Science, 26-29 June 2013, Bacelona, Spain: Effect of Blood Flow Restriction Timing in Enhancing Intramuscular Metabolic Stress During R

    沖田 孝一, 高田 真吾, 菅 唯志, 門口 智泰, 森田 憲輝, 谷浦 有史, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

    北翔大学北方圏生涯スポーツ研究センター年報   2014.4

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    近年、レジスタンス運動に血流制限を併用することで、低強度負荷にも関わらず、高強度負荷と同等の筋力増加・筋肥大が得られることが報告された。このトレーニング方法の効果は、血流制限の併用によって生じる骨格筋の代謝的負荷の増強に起因していると考えられている。この方法は、一般的に複数セットで構成され、血流制限は運動・休息期継続して施行されるが、血流制限の継続は血圧上昇や被験者の苦痛を伴う。これらの問題点は血流制限を運動期もしくは休息期のみに間欠的に行なうことで、軽減可能と考えられる。本研究では血流制限を併用した低強度レジスタンス運動中の、間欠的血流制限とそのタイミングが骨格筋内代謝的負荷に及ぼす影響を検討した。健常男性7名に右足関節低底運動(毎分30回)を最大挙上重量(1RM)の20%を用いて、1分間×3セット施行し(セット間休息各1分)、骨格筋内代謝的負荷は磁気共鳴分光法を用いて測定した。運動条件は、血流制限なし、運動時もしくは休息期のみに間欠的に血流制限を実施した2条件と継続的に血流制限を実施した条件の計4条件とした。また追加実験として、休息期血流制限に30%1RMおよび40%1RMの負荷を用いた条件を施行した。間欠的血流制限における骨格筋内代謝的負荷の増強効果は軽度であり、継続的血流制限に及ばなかった。一方、運動時と休息時の血流制限には差はなかった。しかしながら、負荷量30%1RM以上に増加させることで継続的血流制限と同等のレベルまで増加することも明らかになり、さらに被験者の自覚的疲労度も小さい傾向が認められた。(著者抄録)

  • 心-骨格筋連関 (特集 2025年を見すえた心不全診療ロードマップ : 突破口はどこにあるのか) -- (臓器連関をどう理解するか)

    絹川 真太郎, 沖田 孝一

    内科   2014.3

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  • 一酸化窒素は運動誘発性の運動能力と骨格筋ミトコンドリア増加を調節する

    門口 智泰, 絹川 真太郎, 菅 唯志, 小野 太祐, 横田 卓, 高田 真吾, モハマド・アリ・ソビリン, 高橋 将成, 福島 新, 本間 恒章, 正木 芳宏, 平林 鑑, 沖田 孝一, 筒井 裕之

    心臓リハビリテーション   2014.2

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    【目的】一酸化窒素(NO)合成酵素阻害剤であるL-NAME(LN)を用いて運動誘発性の運動能力と骨格筋ミトコンドリア機能の増加におよぼすNOの役割について検討した。【方法】雄性C57BL/6JマウスをSED(対照群)群、SED+LN群、EX群およびEX+LN群の4群に分け5週間飼育した。運動は水槽内での水泳運動とし、1日90分、週5日の頻度で実施した。LNは飲水(1mg/mL)にて投与した。【結果】小動物用トレッドミルにより評価した仕事量は、SED群に比較してET群で有意に増加したが、EX+LN群では有意に低下した(p<0.05)。また、同時に測定した最高酸素摂取量、骨格筋ミトコンドリアにおけるクエン酸回路・電子伝達系にかかわる因子の酵素活性・遺伝子発現も、SED群に比較しEX群において有意に増加したが(p<0.05)、EX+LN群で有意に減少した。【結論】NOは、運動誘発性の運動能力およびミトコンドリア機能増加における重要な調節因子であることが示唆される。(著者抄録)

  • アンジオテンシンII由来の酸化ストレスは骨格筋異常を引き起こす

    門口 智泰, 絹川 真太郎, 菅 唯志, 高田 真吾, 沖田 孝一, 筒井 裕之

    体力科学   2013.12

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    DOI: 10.7600/jspfsm.62.596

  • 酪酸は運動能力および骨格筋ミトコンドリア機能を増加する

    菅 唯志, 絹川 真太郎, 高田 真吾, 門口 智泰, 伊坂 忠夫, 沖田 孝一, 筒井 裕之

    体力科学   2013.12

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  • 慢性心不全患者における脳由来神経栄養因子の低下は運動耐容能の低下に関連する

    高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

    体力科学   2013.12

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    DOI: 10.7600/jspfsm.62.600

  • Disruption of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

    Ryoichi Katsuyama, Shintaro Kinugawa, Tsuneaki Homma, Takaaki Furihata, Arata Fukushima, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Shouji Matsushima, Hiroyuki Tsutsui

    CIRCULATION   2013.11

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  • Serum Myostatin Levels Are Independent Determinant of Skeletal Muscle Wasting in Patients With Heart Failure

    Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Shouji Matsushima, Takashi Yokota, Hiroyuki Tsutsui

    CIRCULATION   2013.11

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  • Clinical Characteristics, Prognosis, and Management of Hospitalized Patients with Heart Failure in Japan

    Shintaro Kinugawa

    JOURNAL OF CARDIAC FAILURE   2013.10

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  • Skeletal Muscle Abnormalities and Exercise Training in Heart Failure with Preserved Ejection Fraction

    Shintaro Kinugawa

    JOURNAL OF CARDIAC FAILURE   2013.10

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  • Fyn Plays a Critical Role in Regulating Apoptosis of Cardiac Myocyte in Failing Heart through Tyrosine-phosphorylation of Nox4

    Shouji Matsushima, Shintaro Kinugawa, Junichi Sadoshima, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2013.10

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  • Decreased Serum BDNF Levels are Correlated with Lower Exercise capacity in Patients with Heart Failure

    Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2013.10

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  • β遮断薬 (特集 循環器薬 : 使い方プラクティス) -- (疾患別循環器薬の使い方)

    絹川 真太郎, 筒井 裕之

    内科   2013.9

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  • 右膝窩巨大嚢状静脈瘤が血栓塞栓源となり肺動脈血栓塞栓症を発症した一症例

    天満太郎, 木村銀河, 福島新, 絹川真太郎, 納谷昌直, 筒井裕之, 久保田卓, 松居喜郎, 早川峰司

    日本心臓病学会誌   2013.9

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  • 心筋梗塞後の心筋リモデリングおよび心不全におけるNKT細胞の役割 (AYUMI 生活習慣病とNKT細胞 : 病態モジュレーターの面から)

    絹川 真太郎, 筒井 裕之

    医学のあゆみ   2013.7

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  • 心不全における利尿薬耐性の病態と対策 (特集 治療抵抗性心不全における体液コントロール)

    絹川 真太郎, 筒井 裕之

    2013.4

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  • TrkBアゴニストは運動トレーニングによる運動能力向上を模擬する

    高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 森田 憲輝, 沖田 孝一, 筒井 裕之

    体力科学   2012.12

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    DOI: 10.7600/jspfsm.61.619

  • 高齢者における血中脳性神経栄養因子の低下

    谷浦 有史, 沖田 孝一, 高田 真吾, 菅 唯志, 門口 智泰, 絹川 真太郎, 筒井 裕之

    体力科学   2012.12

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  • クルクミンはタンパク分解を抑制して糖尿病誘発性骨格筋萎縮を軽減する

    門口 智泰, 絹川 真太郎, 菅 唯志, 高田 真吾, 小野 太祐, 沖田 孝一, 筒井 裕之

    体力科学   2012.12

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  • BDNF-TrkB Pathway Plays an Important Role in the Effects of Exercise Training on Exercise Capacity and Skeletal Muscle Function in Mice

    Shingo Takada, Shintaro Kinugawa, Tadashi Suga, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takaaki Furihata, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2012.11

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  • The Activation of Natural Killer T Cells Ameliorates Post-Infarct Cardiac Remodeling and Failure in Mice

    Mochamad Ali Sobirin, Shintaro Kinugawa, Masashige Takahashi, Arata Fukushima, Masaru Taniguchi, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    CARDIOVASCULAR THERAPEUTICS   2012.11

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  • Impact of Sarcomere Gene Mutations on Clinical Outcome of Left Ventricular Hypertrophy: Evidence from Comparison with Hypertension-related Hypertrophy

    Takashi Fujita, Noboru Fujino, Tetsuo Konno, Masanori Asakura, Masafumi Kitakaze, Toru Kubo, Yoshinori Doi, Shintaro Kinugawa, Hiroyuki Tsutsui, Issei Komuro, Ryuichiro Anan, Chuwa Tei, Masakazu Yamagishi

    CIRCULATION   2012.11

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  • Endothelial Nitric Oxide (NO) Synthase-Derived NO Plays an Essential Role in the Beneficial Effects of Exercise Training via Activating Skeletal Muscle Mitochondrial Biogenesis

    Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Masaski Yoshihiro, Okita Koichi, Tsutsui Hiroyuki

    CIRCULATION   2012.11

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  • Dipeptidyl Peptidase-4 Inhibitor Can Ameliorate the Decreased Exercise Capacity in Heart Failure After Myocardial Infraction in Mice With the Skeletal Muscle Switch to Oxidative Fiber Type

    Yoshihiro Masaki, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Takaaki Furihata, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2012.11

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  • Skeletal Muscle Abnormalities in Heart Failure

    Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2012.10

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  • 糖尿病と心不全 (特集 糖尿病性心血管合併症 : update)

    筒井 裕之, 絹川 真太郎

    循環器内科   2012.10

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  • The Activation of Invariant Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

    Tsuneaki Homma, Shintaro Kinugawa, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takaaki Furihata, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2012.10

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  • The Activation of (Pro)renin Receptor Plays an Important Role on the Development of Insulin Resistance in Experimental Post-infarct Heart Failure

    Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2012.10

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  • Effect of Exercise with Blood Flow Restriction Depends on Total Work Regardless of Mechanical Intensity

    Shingo Takada, Koichi Okita, Masashi Omokawa, Tadashi Suga, Noriteru Morita, Masahiro Horiuchi, Tomoyasu Kadoguchi, Takashi Sato, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Shintaro Kinugawa, Hiroyuki Tsutsui

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2012.5

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  • 体外式補助人工心臓装着患者に対する心臓リハビリテーションの経験

    阿部隆宏, 堀享一, 横田卓, 絹川真太郎, 後藤大祐, 大岡智学, 久保田卓, 松居喜郎, 筒井裕之, 生駒一憲

    北海道リハビリテーション学会雑誌   2012.5

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  • 梗塞後心不全において酸化ストレスは骨格筋のインスリンシグナルを障害し, インスリン抵抗性を誘導する

    太田 幸博, 絹川 真太郎, 松島 将士, 小野 太祐, アリ ソビリン, 井上 直樹, 横田 卓, 平林 鑑, 筒井 裕之

    北海道醫學雜誌 = Acta medica Hokkaidonensia   2012.4

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  • ピオグリタゾンはインスリン抵抗性患者の骨格筋エネルギー代謝を改善し有酸素運動能を増加させる

    高橋 将成, 絹川 真太郎, 横田 卓, 平林 鑑, 高田 真吾, 菅 唯志, 福島 新, 本間 恒章, 正木 芳宏, 門口 智泰, 佐藤 貴志, 沖田 孝一, 筒井 裕之

    心臓リハビリテーション   2012.2

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    【目的】メタボリック症候群(MetS)患者では有酸素運動能が低下しており、運動療法の障害となっている。ピオグリタゾンは、骨格筋ミトコンドリア機能や脂肪酸酸化に関わる遺伝子発現を誘導することが知られている。MetS患者においてピオグリタゾンが、有酸素運動能を改善させるかどうかを検討した。【方法】運動習慣の無い14人のMetS患者にピオグリタゾン15mg/dayを3ヵ月間投与した。投与前後で、有酸素運動能測定、31P磁気共鳴分光法を用いた足関節底屈運動中(最大挙上重量の20%)の下腿骨格筋高エネルギーリン酸代謝および1H磁気共鳴分光法を用いた筋細胞内脂肪測定を行った。【結果】ピオグリタゾン投与後に、最高酸素摂取量と嫌気代謝閾値は改善した。骨格筋における運動中のクレアチンリン酸低下と筋細胞内脂肪はピオグリタゾン投与後に減少した。【結論】ピオグリタゾンはインスリン抵抗性患者の有酸素運動能を高める有効な治療法であると考えられた。(著者抄録)

  • 酸化ストレスと心不全患者における骨格筋異常

    高田 真吾, 絹川 真太郎, 平林 鑑, 横田 卓, 菅 唯志, 高橋 将成, 福島 新, 本間 恒章, 正木 芳宏, 門口 智泰, 佐藤 貴志, 森田 憲輝, 堀内 雅弘, 沖田 孝一, 筒井 裕之

    心臓リハビリテーション   2012.2

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    【背景・目的】心不全患者における運動能力低下は筋内エネルギー代謝異常および筋細胞内脂肪蓄積(IMCL)に密接に関連している。しかしながら、これらの異常の機序は明らかではない。我々は酸化ストレスの亢進が骨格筋異常に関連していると仮説を立てた。【方法・結果】拡張型心筋症患者(DCM;10名、左室駆出率<40%、NYHA I~III)および同年齢の健常者(9名)を対象とした。最高酸素摂取量はDCMで有意に低値であった。31P-磁気共鳴分光法(MRS)により、20%1RM(最大挙上重量)の定常負荷を用いた仰臥位右足関節底屈運動中のクレアチンリン酸低下(PCr loss)はDCMで有意に低下した。1H-MRSを用いて測定したIMCLはDCMで2.1倍に増加した。DCMにおいて、血漿SOD活性は減少し、チオバルビツール酸反応性物質(TBARS)は増加した。SOD活性およびTBARSは最高酸素摂取量、PCr loss、およびIMCLと有意に相関した。【結論】酸化ストレスは骨格筋代謝障害およびIMCL増加に重要な役割を果たしており、心不全患者の運動能力を低下させる可能性が示唆された。(著者抄録)

  • 診断へのアプローチ(病歴聴取と身体診察)

    絹川 真太郎, 筒井 裕之

    日本内科学会雑誌   2012.2

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    DOI: 10.2169/naika.101.338

  • 血流制限を併用した筋力トレーニングの効果 女性における至適方法の検討へ

    沖田 孝一, 絹川 真太郎, 横田 卓, 森田 憲輝, 佐々木 浩子

    女性健康科学研究会受賞研究報告集   2012.1

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    女性および男性における血流制限を併用したレジスタンス運動の効果を単回運動時の筋内代謝的ストレスから評価し、その差異について検討した。仰臥位における右足関節底屈運動を毎分30回のペースで、総計60回(2分間)施行した。女性の最大挙上重(1-RM)は男性に比べて有意に低かったため、各条件における絶対的負荷量は、女性において低値となった。また、収縮期血圧も女性において低値であったため血流制限圧も低くなった。安静から運動時における骨格筋内クレアチンリン酸は、各条件・時間において、男女間の有意差は見られなかった。65%1-RM条件において、女性における筋細胞内pHの低下が小さいように見えるが、クレアチンリン酸同様に各条件・時間においても男女間の有意差はみられなかった。男性、女性同様に血流制限により有意にクレアチンリン酸、筋細胞内pHの低下は増強したが、高強度負荷には及んでいなかった。

  • アンジオテンシンII受容体阻害薬は高脂肪食誘発糖尿病マウスにおける運動能力低下を改善する

    高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

    体力科学   2011.12

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  • 血液依存性血管拡張反応 上下肢および男女における検討

    谷浦 有史, 沖田 孝一, 佐藤 貴志, 菅 唯志, 高田 真吾, 門口 智泰, 森田 憲輝, 高橋 将成, 福島 新, 絹川 真太郎, 堀内 雅弘, 筒井 裕之

    体力科学   2011.12

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  • 血流依存性血管拡張能と筋力における関連性の検討

    門口 智泰, 沖田 孝一, 菅 唯志, 高田 真吾, 佐藤 貴志, 面川 雅司, 森田 憲輝, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

    体力科学   2011.12

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  • レジスタンス運動が動脈機能へ与える影響 血流制限を併用した検討

    佐藤 貴志, 沖田 孝一, 菅 唯志, 高田 真吾, 門口 智泰, 森田 憲輝, 高橋 将成, 福島 新, 絹川 真太郎, 鎌倉 一, 堀内 雅弘, 筒井 裕之

    体力科学   2011.12

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  • Angiotensin II Receptor Blocker Improves Exercise Capacity and Mitochondrial Function of Skeletal Muscle via Inhibiting Oxidative Stress in High Fat Diet-Induced Diabetic Mice

    Shingo Takada, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Sobirin A. Mochamad, Taisuke Ono, Yoshihiro Masaki, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • Nitric Oxide is Involved the Beneficial Effects of Exercise Training via Activating Skeletal Muscle Mitochondrial Biogenesis in Mice

    Tadashi Suga, Shintaro Kinugawa, Taisuke Ono, Takashi Yokota, Shingo Takada, Mochamad A. Sobirin, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Tomoyasu Kadoguchi, Yoshihiro Masaki, Kagami Hirabayashi, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • Enhanced Oxidative Stress is Correlated With Skeletal Muscle Abnormalities in Patients With Metabolic Syndrome

    Shintaro Kinugawa, Takashi Yokota, Kagami Hirabayashi, Tadashi Suga, Masashige Takahashi, Shingo Takada, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • Direct Renin Inhibitor Ameliorates Insulin Resistance by Improving Insulin Signaling in the Skeletal Muscle in Experimental Post-Infarct Heart Failure

    Arata Fukushima, Shintaro Kinugawa, Takashi Yokota, Sobrin A. Mochamad, Masashige Takahashi, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Kouichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • The Activation of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

    Tsuneaki Homma, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Taisuke Ono, Mochamad A. Sobirin, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • The Enhanced Oxidative Stress is Associated with Skeletal Muscle Abnormalities in Patients with Heart Failure

    Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Masashige Takahashi, Shingo Takada, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • The Disruption of Natural Killer T Cell Receptor Exacerbates Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

    Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Mochamad A. Sobirin, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Yoshihiro Masaki, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • The Disruption of Natural Killer T Cell Exacerbates Cardiac Hypertrophy and Heart Failure Due to Pressure Overload in Mice

    Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Mochamad A. Sobirin, Tadashi Suga, Shingo Takada, Taisuke Ono, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

    CIRCULATION   2011.11

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  • Direct Renin Inhibitor (Aliskiren) Improves Insulin Resistance and Impaired Insulin Signal in Post-Infarct Heart Failure

    Arata Fukushima, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2011.9

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  • The Disruption of Natural Killer T cell Exacerbates Cardiac Hypertrophy and Heart Failure Due to Pressure Overload in Mice

    Shintaro Kinugawa, Masashige Takahashi, Shingo Takada, Arata Fukushima, Tomoyasu Kadoguchi, Tadashi Suga, Mochamad Ali Sobirin, Taisuke Ono, Tsuneaki Homma, Hiroyuki Tsutsu

    JOURNAL OF CARDIAC FAILURE   2011.9

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  • The Activation of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

    Tsuneaki Homma, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2011.9

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  • The activation of natural killer T cells ameliorates post-infarct heart failure in mice

    M. A. Sobirin, S. Kinugawa, M. Takahashi, T. Ono, A. Fukushima, T. Yokota, T. Homma, N. Ishimori, K. Iwabuchi, H. Tsutsui

    EUROPEAN HEART JOURNAL   2011.8

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  • 腎障害合併心不全の病態と治療 (特集 利尿薬と心不全)

    絹川 真太郎, 筒井 裕之

    2011.7

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  • Discharge Use of Spironolactone was Associated with Lower Long-term Mortality in Patients Hospitalized with Systolic Heart Failure

    Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Miyuki Tsuchihashi-Makaya, Hiroyuki Tsutsui

    CIRCULATION   2010.11

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  • 慢性心不全の患者背景,治療,長期予後における性差

    眞茅みゆき, 絹川真太郎, 濱口早苗, 後藤大祐, 古本智夫, 横式尚司, 筒井裕之

    日本高血圧学会総会プログラム・抄録集   2010.10

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  • Pioglitazone increases the aerobic capacity with improved skeletal muscle energetics in patients with insulin resistance

    T. Yokota, S. Kinugawa, K. Hirabayashi, T. Suga, S. Takada, M. Takahashi, S. A. Mochamad, T. Ono, N. Morita, K. Okita, H. Tsutsui

    DIABETOLOGIA   2010.9

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  • The Effect on Intramuscular Metabolic Stress During Low-Intensity Resistance Exercise With Blood Flow Restriction in Patients With Heart Failure

    Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Tadashi Suga, Arata Fukushima, Tomoyasu Kadoguchi, Kagami Hirabayashi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2010.9

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  • The Disruption of Natural Killer T Cell Receptor Exacerbates Post-Infarct Heart Failure in Mice

    Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2010.9

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  • The Activation of Natural Killer T Cells Ameliorates Post-Infarct Heart Failure in Mice

    Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2010.8

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  • 慢性心不全に対する運動療法の継続に及ぼす患者背景因子の検討

    後藤大祐, 堀享一, 絹川真太郎, 横田卓, 小島尚子, 筒井裕之

    心臓リハビリテーション   2010.6

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  • 血流制限を併用した短期間の低強度筋力トレーニングが筋量・筋力および動脈硬化指標に与える影響

    門口智泰, 沖田孝一, 菅唯志, 高田真吾, 面川雅司, 佐藤貴志, 今泉貴, 森田憲輝, 高橋将成, 横田卓, 平林鑑, 絹川真太郎, 筒井裕之

    心臓リハビリテーション   2010.6

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  • Difference In Metabolic Stress During Resistance Exercise With Blood Flow Restriction Between Sprinters And Endurance Runners

    Tomoyasu Kadoguchi, Koichi Okita, Tadashi Suga, Shingo Takada, Masashi Omokawa, Noriteru Morita, Masahiro Horiuchi, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Shintaro Kinugawa, Hiroyuki Tsutsui

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2010.5

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  • High-metabolic Stress During Resistance Exercise Might Provide Muscle Hypertrophy And Strength Increase Even With Low-mechanical Stimulus

    Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Tomoyasu Kadoguchi, Noriteru Morita, Masahiro Horiuchi, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Shintaro Kinugawa, Hiroyuki Tsutsui

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2010.5

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  • Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) (vol 73, pg 1893, 2009)

    Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Hisashi Yokoshiki, Norihiro Kato, Akira Takeshita, Hiroyuki Tsutsui

    CIRCULATION JOURNAL   2009.12

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  • Pioglitazone Improves Aerobic Capacity and Skeletal Muscle High-Energy Phosphate Metabolism in Patients With Metabolic Syndrome

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Noriteru Morita, Masahige Takahashi, Shingo Takada, Masashi Omokawa, Shouji Matsushima, Mochamad A. Sobirin, Taisuke Ono, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2009.11

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  • The Increase in Intramyocellular Lipid in Leg Skeletal Muscle is Associated With Lowered Aerobic Exercise Capacity in Patients With Heart Failure

    Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Noriteru Morita, Taisuke Ono, Mochamad A. Sobirin, Masashige Takahashi, Koichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2009.11

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  • Role of Chronic Inflammation in Left Ventricular Remodeling and Failure After Myocardial Infarction

    Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2009.9

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  • The Increase in Intramyocellular Lipid in Leg Skeletal Muscle is Associated With Lowered Aerobic Exercise Capacity in Heart Failure Patients

    Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Noriteru Morita, Taisuke Ono, Mochamad Ali Sobirin, Masashige Takahashi, Koichi Okita, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2009.9

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  • The Activation of Natural Killer T Cells Ameliorates Post-Infarct Heart Failure in Mice

    Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2009.9

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  • 重症心機能障害を併発した強皮症患者の治療に難渋した一例

    有賀伸, 榊原守, 野澤篤史, 穴田真奈美, 納谷昌直, 絹川真太郎, 古本智夫, 筒井裕之

    2009.4

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  • 新規開発臓器保存液を用いた心冷保存限界延長の試み

    若山 顕治, 深井 原, 山下 健一郎, 後藤 了一, 植木 伸也, 福森 大介, 柴崎 晋, 大浦 哲, 廣方 玄太郎, 芳賀 早苗, 谷口 雅彦, 鈴木 友己, 嶋村 剛, 松下 道明, 古川 博之, 尾崎 倫孝, 藤堂 省, 小野 太祐, 絹川 真太郎, 筒井 裕之, 菅原 満

    日本外科学会雑誌   2009.2

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  • 画像診断と病理 強皮症に伴う心筋症

    藤間憲幸, 大山徳子, 榊原守, 納谷昌直, 絹川真太郎, 久保田佳奈子, 松野吉宏

    画像診断   2008.11

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  • 30) 修正大血管転位症術後のAFLに対して,アブレーション治療が有効だった1例(第99回日本循環器学会北海道地方会)

    渡邉 昌也, 安藤 康博, 絹川 真太郎, 川嶋 望, 三山 博史, 下川 淳一, 横式 尚司, 山田 聡, 筒井 裕之, 西浦 猛, 大場 淳一, 松居 喜郎

    2008.10

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  • Type 2 Diabetes Is Associated with the Exacerbation of Heart Failure via Increasing Myocardial NAD(P)H Oxidase-Derived Superoxide Production

    Shintaro Kinugawa, Shouji Matsushima, Takashi Yokota, Yukihiro Ohta, Naoki Inoue, Hiroyuki Tsutsui

    CIRCULATION   2008.10

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  • Impaired Skeletal Muscle Energy Metabolism Limits Aerobic Exercise Capacity in Patients with Metabolic Syndrome

    Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Naoki Inoue, Yukihiro Ohta, Shouji Matsushima, Sanae Hamaguchi, Mochamad A. Sobirin, Taisuke Ono, Noriteru Morita, Kouichi Okita, Hiroyuki Tsutsui

    CIRCULATION   2008.10

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  • Beta-blocker use at discharge in patients hospitalized for heart failure is associated with improved survival: An analysis from JCARE-CARD

    Miyuki Makaya, Hiroyuki Tsutsui, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Akira Takeshita

    JOURNAL OF CARDIAC FAILURE   2008.9

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  • Oxidative stress through the activation of renin-angiotensin system in skeletal muscle causes insulin resistance in mice with heart failure

    Shintaro Kinugawa, Yukihiro Ohta, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2008.9

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  • Novel treatment strategies against left ventricular remodeling and failure after infarction by attenuating mitochondrial oxidative stress

    Shintaro Kinugawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2008.9

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  • 7) 冠動脈左室憩室瘻と心室中隔欠損を合併した1例(第98回日本循環器学会北海道地方会)

    川崎 いくみ, 渡邉 昌也, 安藤 康博, 岡田 昌子, 絹川 真太郎, 川嶋 望, 山田 聡, 筒井 裕之

    2008.4

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  • NOS dependent gene regulation in cardiac tissues of conscious type I diabetic dogs

    Caroline Ojaimi, Shintaro Kinugawa, Thomas H. Hintze

    FASEB JOURNAL   2008.4

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  • 血流制限下低強度レジスタンス運動中の筋内エネルギー代謝

    菅 唯志, 沖田 孝一, 高田 真吾, 高橋 智宏, 面川 雅司, 森田 憲輝, 堀内 雅弘, 平林 鑑, 横田 卓, 絹川 真太郎, 筒井 裕之

    心臓リハビリテーション   2008.1

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    磁気共鳴分光法(31P-MRS)を用いて、血流制限下低強度レジスタンス運動中の筋内エネルギー代謝を明らかにし、自然血流下の低強度および高強度レジスタンス運動中と比較検討した。明らかな疾患をもたない健常男性15例を対象とした。被験者の右下腿部下に31P-MRS専用の表面コイルを装着し、右下腿三頭筋の最大筋腹部位を分析対象として行った。低強度負荷条件として、最大挙上重量(1RM)の20%を用いた低強度条件(L)と、血流制限を併用した低強度血流制限条件(LI)、および1RMの65%を用いた高強度条件(H)の3条件による動的足底屈運動を2分間(毎分30回)行い、筋内エネルギー代謝を測定した。LIのクレアチンリン酸および筋内pHの変化は、Lに比較して有意に大きかったが、LIのこれらの変化は、Hに比較して有意に小さかった。

  • 34)左室流出路狭窄を合併した重症大動脈弁狭窄症に弁置換術と同時に心筋切除術を施行した一例(第97回日本循環器学会北海道地方会)

    平林 鑑, 笹井 春江, 相馬 孝光, 絹川 真太郎, 古本 智夫, 山田 聡, 横式 尚司, 小野塚 久夫, 筒井 裕之, 松居 喜郎

    2007.10

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  • 左心補助装置から離脱しえた巨細胞性劇症型心筋炎の1例

    平林 鑑, 山田 聡, 石見 かおり, 絹川 真太郎, 蒔田 直昌, 岡本 洋, 筒井 裕之, 杉木 宏司, 村下 十志文, 中川 雄太

    日本内科学会雑誌   2007.2

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    DOI: 10.2169/naika.96.335

  • Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress

    Nobuhiro Suematsu, Caroline Ojaimi, Shintaro Kinugawa, Xiaobin Xu, Fabio Recchia, Thomas Hintze

    CIRCULATION   2006.10

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  • National registry of patients with chronic heart failure in Japan - JCARE study

    Hiroyuki Tsutsui, Miyuki Tsuchihashi, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

    JOURNAL OF CARDIAC FAILURE   2006.10

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  • NAD(P)H oxidase-derived oxidative stress is involved in the exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction

    Shouji Matsushima, Shintaro Kinugawa, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Kenji Sunagawa, Hiroyuki Tsutsui

    JOURNAL OF CARDIAC FAILURE   2006.10

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  • 心不全における酸化ストレスの役割 (第1土曜特集 酸化ストレスと心血管疾患--分子機構の解明から治療への応用まで) -- (病態形成における酸化ストレスの役割)

    絹川 真太郎, 筒井 裕之

    医学のあゆみ   2006.7

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  • 心不全における骨格筋異常一酸化窒素と酸化ストレスの役割

    筒井 裕之, 絹川 真太郎, 沖田 孝一

    循環制御 = CIRCULATION CONTROL   2006.6

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  • Chronic hyperhomocysteinemia regulates cardiac myocyte gene expression creating a cardiac metabolic disease

    C Ojaimi, N Suematsu, S Kinugawa, TH Hintze

    FASEB JOURNAL   2006.3

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  • 酸素消費量と一酸化窒素(NO)

    絹川 真太郎, 筒井 裕之

    循環器専門医 : 日本循環器学会専門医誌   2006.3

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  • 嫌気閾値

    絹川 真太郎, 筒井 裕之

    循環器専門医 : 日本循環器学会専門医誌   2006.3

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  • Wassermanの歯車

    絹川 真太郎, 筒井 裕之

    循環器専門医 : 日本循環器学会専門医誌   2006.3

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  • Hyperhomocysteinemia alters the cardiac metabolism by impairing nitric oxide bioavailability through oxidative stress

    N Suematsu, S Kinugawa, XB Xu, TH Hintze

    FASEB JOURNAL   2006.3

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  • Overexpression of glutathione peroxidase attenuates cardiac remodeling and diastolic dysfunction in diabetic mice

    S Matsushima, T Ide, H Matsusaka, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   2005.12

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  • Overexpression of mitochondrial peroxiredoxin-3 ameliorates left ventricular remodeling and failure after myocardial infarction in mice

    S Matsushima, H Matsusaka, M Ikeuchi, T Ide, T Kubota, K Sunagawa, F Hattori, Y Hasagawa, T Kurihara, S Oikawa, S Kinugawa, H Tsutsui

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   2005.12

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  • Superoxide/endothelial nitric oxide synthase-derived nitric oxide interaction controls substrate utilization during exercise

    P Serpillon, S Kinugawa, FA Recchia, TH Hintze

    CIRCULATION   2005.10

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  • A defect of neuronal nitric oxide synthase increases xanthine oxidase derived-superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase

    S Kinugawa, HR Huang, ZP Wang, PM Kaminski, MS Wolin, TH Hintze

    FASEB JOURNAL   2005.3

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  • Impaired endothelial nitric oxide production from coronary microvessels induced by cAMP signal transduction in diabetic dog heart

    XP Zhang, S Kinugawa, T Hintze

    FASEB JOURNAL   2004.3

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  • Angiotensin II stimulation inhibits modulation of myocardial oxygen consumption by endogenous nitric oxide

    S Kinugawa, P Kaminski, H Huang, XB Xu, M Wolin, TH Hintze

    FASEB JOURNAL   2003.3

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  • Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes inhibited by ascorbate and mediated by increased local angiotensin II

    S Kinugawa, H Post, XP Zhang, XB Xu, H Huang, FA Recchia, M Ochoa, P Kaminski, M Wolin, TH Hintze

    FASEB JOURNAL   2003.3

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  • Effects of amiodarone on heart cells - Response

    H Tsutsui, T Ide, S Kinugawa, A Takeshita, H Utsumi

    CIRCULATION   2000.11

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  • Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury

    H Tsutsui, T Ide, S Kinugawa, N Suematsu, H Utsumi

    CIRCULATION   1999.11

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  • Role of oxidative stress in left ventricular remodeling and heart failure after myocardial infarction

    S Kinugawa, H Tsutsui, T Ide, S Yamamoto, N Suematsu, S Satoh, H Utsumi, A Takeshita

    CIRCULATION   1999.11

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  • Enhanced myocardial generation of oxygen radicals in heart failure

    T Ide, T Tsutsui, S Kinugawa, H Utsumi, N Hattori, K Uchida, H Tagawa

    CIRCULATION   1998.10

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  • Active force development in isolated chemically skinned myocytes are normal in heart failure

    S Kinugawa, H Tsutsui, S Satoh, M Takahashi, K IgarashiSaito, H Tagawa

    CIRCULATION   1997.10

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    Language:English  

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Industrial property rights

Patent   Number of applications: 0   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 国際心臓研究会日本部会

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  • THE JAPANESE CIRCULATION SOCIETY

  • JAPANESE HEART FAILURE SOCIETY

  • 日本心臓リハビリテーション学会

  • JAPANESE COLLEGE OF CARDIOLOGY

  • 日本生化学学会

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Committee Memberships

  • 日本循環器学会   ガイドライン委員会幹事   Domestic

    2014.7 - 2016.7   

  • Councilor   Domestic

    2011.7 - Present   

  • Councilor   Domestic

    2011.7 - 2023.6   

  • Councilor   Domestic

    2008.7 - Present   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:25

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:30

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:25

  • シンポジウム

    日本心不全学術集会  2019.10 - 2023.6

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    Type:Competition, symposium, etc. 

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Research Projects

  • O結合グリコシル化制御に基づくサルコペニアの新規治療法開発

    Grant number:22K19754  2022 - 2023

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 心不全に合併するサルコペニアの機序解明

    2022 - 2023

    先進医薬研究振興財団 循環医学分野 一般助成

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    Authorship:Principal investigator  Grant type:Contract research

  • O結合グリコシル化制御によるサルコペニア治療法開発

    2022

    上原記念生命財団研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • O-結合グリコシル化制御に基づくサルコペニアの新規治療法の開発

    2022

    ノバルティス科学振興財団研究奨励金

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    Authorship:Principal investigator  Grant type:Contract research

  • ペマフィブラートの心不全における骨格筋異常に対する影響の検討

    2021.11 - 2023.3

    受託研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • マイオカインによる老化進展制御機構の解明

    Grant number:21H03360  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 脳由来神経栄養因子によるミトコンドリア機能制御機構の解明

    2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 心不全モデルマウスにおける運動能力低下および骨格筋異常に対するエンパグリフロジンの保護効果および作用メカニズムの検討

    2017.7 - 2019.7

    受託研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • ナノカプセルを用いた拡張型心筋症に対するミトコンドリアをターゲットとした新規治療法の開発

    2016 - 2017

    日本医療研究開発機構研究費難治性疾患実用化研究事業

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    Authorship:Principal investigator  Grant type:Contract research

  • 骨格筋不全におけるmitoNEETによるミトコンドリア機能制御の分子機構の解明

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • メタボリックシンドロームにおける運動能力低下の分子機構の解明と治療への応用

    2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ミトコンドリア酸化ストレス制御による運動能力改善の新たな治療法の開発

    2006 - 2007

    科学研究費助成事業  若手研究(A,B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 生理機能検査学I, II, III

    2024.4 - 2024.9   First semester

  • 臨床医学III

    2024.4 - 2024.9   First semester

  • 臨床医学基本実習

    2023.10 - 2024.3   Second semester

  • 臨床検査学II

    2023.10 - 2024.3   Second semester

  • 系統医学II

    2023.10 - 2024.3   Second semester

  • 生理機能検査学I、II、III

    2023.4 - 2023.9   First semester

  • 臨床医学III

    2023.4 - 2023.9   First semester

  • 臨床検査学II

    2022.10 - 2023.3   Second semester

  • 系統医学II

    2022.10 - 2023.3   Second semester

  • 生理機能検査学II, III

    2022.4 - 2022.9   First semester

  • 臨床医学III

    2022.4 - 2022.9   First semester

  • 臨床検査学講義

    2021.10 - 2022.3   Second semester

  • 臨床基本実習

    2021.10 - 2022.3   Second semester

  • 系統医学II(循環器)

    2021.10 - 2022.3   Second semester

  • 生理機能検査学II, III

    2021.4 - 2021.9   First semester

  • 臨床医学III

    2021.4 - 2021.9   First semester

  • 系統医学II(循環器)

    2020.10 - 2021.3   Second semester

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Social Activities

  • 健康寿命を延ばすために―運動の重要性

    西日本新聞  2023.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 循環器疾患の予防と治療-運動について-

    北海道新聞  2018.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 心疾患と運動

    北海道心臓協会  2016.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 肥大型心筋症とうまくつきあうために

    札幌市難病医療相談会  2014.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

Media Coverage

  • 教えて!ドクター 家族の健康 TV or radio program

    BSジャパン  2015.3

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    教えて!ドクター 家族の健康

  • 心臓財団 虚血性心疾患セミナー TV or radio program

    ラジオNIKKEI  2014.12

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    心臓財団 虚血性心疾患セミナー

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Cardiology

Clinician qualification

  • Certifying physician

    日本心臓リハビリテーション学会

  • Specialist

    The Japanese Circulation Society(JCS)

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 1994

Notable Clinical Activities

  • 心不全チームリーダーとして治療方針の決定を行っている 院内心臓移植委員会の副委員長として心臓移植適応の判断を行っている 心臓リハビリテーションの普及活動を行っている