Triglyceride-glucose index associated with future renal function decline in the general population 査読

Yoshida D, Ikeda S, Shinohara K, Kazurayama M, Tanaka S, Yamaizumi M, Nagayoshi H, Toyama K, Kinugawa S

J Gen Intern Med   2024年5月

The effects of renal denervation on blood pressure, cardiac hypertrophy, and sympathetic activity during the established phase of hypertension in spontaneously hypertensive rats. 査読 国際誌

Katsuki M, Shinohara K, Kinugawa S, Hirooka Y.

Hypertens Res   47 ( 4 )   1073 - 1077   2024年4月

Overview of the 87th annual scientific meeting of the Japanese Circulation Society (JCS2023) - New Challenge With Next Generation 査読 国際誌

Matoba T, Nakano Y Katsuki S, Ide T, Matsushima S, FujinoT, Hashimoto T, Shinohara K, Abe K, Hosokawa K, Sakamoto T, Sakamoto I, Kakino T, Ishikita A, Nishizaki A, Sakamoto K, Takase S, Nagayama T, Tohyama T, Nagata T, Kinugawa S, Tsutsui H

Circ J   88 ( 4 )   615 - 619   2024年3月

Perforation of the chest wall from bioprosthetic pulmonary valve endocarditis 査読 国際誌

Nishizaki A, Ishikita A, Kakino T, Sakamoto I, Shiose A, Kinugawa S

J Echocardiogr   2024年3月

Paced QRS morphology mimicking complete left bundle branch block induced by right ventricular pacing is associated with pacing-induced cardiomyopathy. 査読 国際誌

Ikeda S, Sakamoto K, Sunagawa M, Yakabe D, Nagaoka K, Kowase S, Inoue S, Morishige K, Mukai Y, Tsutsui H, Kinugaw S

J Cardiovasc Electrophysiol   2024年1月

Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: comparison with conventional catheters. 査読 国際誌

Takase S, Mukai Y, Nagaoka K, Ogawa K, Kawai S, Honda N, Nagayama T, Tohyama T, Inoue S, Sadamatsu K, Tashiro H, Sakamoto K, Matoba T, Chishaki A, Kinugawa S, Tsutsui H

Pacing Clin Electrophysiol   47 ( 1 )   5 - 18   2024年1月

Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population 査読 国際誌

Ikeda S, Shinohara K, Tagawa K, Tohyama T, Kishimoto J, Kazurayama M, Tanaka S, Yamaizumi M, Nagayoshi H, Toyama K, Matsushima S, Tsutsui H, Kinugawa S

Sci Rep   14 ( 1 )   2024年1月

Hemoglobin level can predict heart failure hospitalization in patients with advanced heart failure awaiting heart transplantation without inotropes or mechanical circulatory support 査読

Suenaga T, Fujino T, Hashimoto T, Ishikawa Y, Shinohara K, Matsushima S, Komman H, Toyosawa M, Ide T, Tsutsui H, Shiose A, Kinugawa S

Int Heart J   65 ( 4 )   667 - 675   2024年

Development of deep-learning models for real-time anaerobic threshold and peak VO2 prediction during cardiopulmonary exercise testing. 査読 国際誌

Watanabe T, Tohyama T, Ikeda M, Fujiono T, Hashimoto T, Matsushima S, Kishimoto J, Todaka K, Kinugawa S, Tsutsui H, Ide T

Eur J Prev Cardiol   31 ( 4 )   448 - 457   2023年4月

The AppCare-HF randomized clinical trial: a feasibility study of a novel self-care support mobile app for individuals with chronic heart failure 査読 国際誌

Yokota T, Fukushima A, Tsuchihashi-Makaya M, Abe T, Takada S, Furihata T, Ishimori N, Fujno T, Kinugawa S, Ohta M, Kakinoki S, Yokota I, Endoh A, Yoshino M, Tsutsui H

Eur Heart J Digit Health   4 ( 4 )   325 - 336   2023年2月

ZBP1 protects against mtDNA-induced myocardial inflammation in failing hearts 査読 国際誌

Enzan N, Matsushima S, Ikeda S, Okabe K, Ishikita A, Yamamoto T, Sada M, Miyake R, Tsutsui Y, Nishimura R, Toyohara T, Ikeda Y, Shojima Y, Miyamoto HD, Tadokoro T, Ikeda M, Abe K, Ide T, Kinugawa S, Tsutsui H

Circ Res   132 ( 9 )   1110 - 1126   2023年2月

Enahanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults 査読 国際誌

Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T

Sci Rep   13 ( 1 )   5203   2023年1月

Nationwide temporal trends in clinical characteristics and treatment of dilated cardiomyopathy from 2003 to 2013 in Japan – A report from clinical personal records 査読 国際誌

87 ( 4 )   500 - 507   2022年10月

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure 査読 国際誌

Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H

Proc Natl Acad Sci USA   119 ( 41 )   2022年10月

JCS/JACR 2021 guideline on rehabilitation in patients with cardiovascular disease 査読 国際誌

Makita S, Yasu T, Akashi YJ, Adachi H, Izawa H, Ishihara S, Iso Y, Ohuchi H, Omiya K, Ohya Y, Okita K, Kimura Y, Koike A, Kohzuki M, Koba S, Sata M, Shimada K, Shimokawa T, Shiraishi H, Sumitomo N, Takahashi T, Takura T, Tsutsui H, Nagayama M, Hasegawa E, Fukuomoto Y, Furukawa Y, Miura S, Yasuda S, Yamada S, Yamada Y, Yumino D, Yoshida T, Adachi T, Ikegame T, Izawa KP, Ishida T, Ozasa N, Osada N, Obata H, Kakutani N, Kasahara Y, Kato M, Kamiya K, Kinugawa S, Kono Y, Kobayashi Y, Koyama T, Sase K, Sato S, Shibata T, Suzuki N, Tamaki D, Yamaoka-Tojo M, Nakanishi M, Nakane E, Nishizaki M, Higo T, Fujimi K, Honda T, Matsumoto Y, Matsumoto N, Miyawaki I, Murata M, Yagi S, Yanase M, Yamada M, Yokoyama M, Watanabe N, Ito H, Kimura T, Kyo S, Goto Y, Nohara R, Hirata K; on behalf of the Japanese Circulation Society/the Japanese Association of Cardiac Rehabilitation Joint Working Group

Circ J   87 ( 1 )   155 - 235   2022年7月

Protect roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation 査読 国際誌

Tokuyama T, Uosaki H, Sugiura A, Nishitani G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A, Hirai H, Ishido S, Yoshizawa T, Shindo T, Takda S, Kinugawa S, Inatome T, Yanagi S

iScience   25 ( 7 )   2022年7月

Home-based cardiac rehabilitation using information and communication technology for heart failure patients with frailty 査読 国際誌

Nagatomi Y, Ide T, Nezu T, FujinoT, Yohyama T, Nagata T, Higo T, Hashimoto T, Matsushima S, Shinohara K, Yokoyama T, Eguchi A, Ogusu A, Ikeda M, Ishikawa Y, Yamashita F, Kinugawa S, Tsutsui H

ESC Heart Fail   2022年4月

Diagnostic performance of nutritional indicators in patients with heart failure 査読 国際誌

Kinugasa Y, Sota T, Kamitani H, Kakutani N, Nakayama N, Nakamura K, Hirai M, Yanagihara K, Kato M, Ono T, Takahashi M, Matsuo H, Matsukawa R, Yoshida I, Himura Y, Yokota T, Yamamoto K, Tsuchihashi-Makaya M, Kinugawa S.

ESC Heart Fail   2022年2月

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure 査読

Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa

Communications Biology   4 ( 1 )   2021年12月

Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients 査読

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Mayumi Yamato, Shingo Takada, Tadashi Suga, Ippei Nakano, Arata Fukushima, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

Scientific Reports   11 ( 1 )   2021年12月

Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice 査読

Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa

BMC Pharmacology and Toxicology   22 ( 1 )   2021年12月

JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure. 査読

Hiroyuki Tsutsui, Tomomi Ide, Hiroshi Ito, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Miyuki Makaya, Toyoaki Murohara, Koichi Node, Yoshihiko Saito, Yasushi Sakata, Wataru Shimizu, Kazuhiro Yamamoto, Yasuko Bando, Yu-Ki Iwasaki, Yoshiharu Kinugasa, Isamu Mizote, Hitoshi Nakagawa, Shogo Oishi, Akiko Okada, Atsushi Tanaka, Takashi Akasaka, Minoru Ono, Takeshi Kimura, Shun Kosaka, Masami Kosuge, Shin-Ichi Momomura

Circulation journal : official journal of the Japanese Circulation Society   2021年9月

GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway 査読 国際誌

Ishikita A, Matsushima S, Ikeda S, Okabe K, Tadokoro T, Enzan N, Yamamoto T, Sada M, Tsutsui Y, Miyake R, Ikeda M, Ide T, Kinugawa S, Tsutsui H

iScience   24 ( 12 )   2021年9月

JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure. 査読 国際誌

Hiroyuki Tsutsui, Tomomi Ide, Hiroshi Ito, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Miyuki Makaya, Toyoaki Murohara, Koichi Node, Yoshihiko Saito, Yasushi Sakata, Wataru Shimizu, Kazuhiro Yamamoto, Yasuko Bando, Yu-Ki Iwasaki, Yoshiharu Kinugasa, Isamu Mizote, Hitoshi Nakagawa, Shogo Oishi, Akiko Okada, Atsushi Tanaka, Takashi Akasaka, Minoru Ono, Takeshi Kimura, Shun Kosaka, Masami Kosuge, Shin-Ichi Momomura

Journal of cardiac failure   2021年9月

Angiotensin-converting enzyme inhibitor prevents skeletal muscle fibrosis in diabetic mice. 査読 国際誌

Naoya Kakutani, Shingo Takada, Hideo Nambu, Satoshi Maekawa, Hikaru Hagiwara, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Yoshizuki Fumoto, Soichiro Hata, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa

Experimental physiology   106 ( 8 )   1785 - 1793   2021年8月

JCS/JHFS 2018 Guideline on the Diagnosis and Treatment of Cardiomyopathies.

Hiroaki Kitaoka, Hiroyuki Tsutsui, Toru Kubo, Tomomi Ide, Taishiro Chikamori, Keiichi Fukuda, Noboru Fujino, Taiki Higo, Mitsuaki Isobe, Chizuko Kamiya, Seiya Kato, Yasuki Kihara, Koichiro Kinugawa, Shintaro Kinugawa, Shigetoyo Kogaki, Issei Komuro, Nobuhisa Hagiwara, Minoru Ono, Yuichiro Maekawa, Shigeru Makita, Yoshiro Matsui, Shouji Matsushima, Yasushi Sakata, Yoshiki Sawa, Wataru Shimizu, Kunihiko Teraoka, Miyuki Tsuchihashi-Makaya, Hatsue Ishibashi-Ueda, Masafumi Watanabe, Michihiro Yoshimura, Arata Fukusima, Satoshi Hida, Shungo Hikoso, Teruhiko Imamura, Hiroko Ishida, Makoto Kawai, Toshiro Kitagawa, Takashi Kohno, Satoshi Kurisu, Yoji Nagata, Makiko Nakamura, Hiroyuki Morita, Hitoshi Takano, Tsuyoshi Shiga, Yasuyoshi Takei, Shinsuke Yuasa, Teppei Yamamoto, Tetsu Watanabe, Takashi Akasaka, Yoshinori Doi, Takeshi Kimura, Masafumi Kitakaze, Masami Kosuge, Morimasa Takayama, Hitonobu Tomoike

Circulation journal : official journal of the Japanese Circulation Society   85 ( 9 )   1590 - 1689   2021年8月

Impact of citrus fruit intake on the mental health of patients with chronic heart failure 査読 国際誌

Kakutani N, Yokota T, Fukushima A, Obata Y, Ono T, Sota T, Kinugasa Y, Takahashi M, Matsuo H, Matsukawa R, Yoshida I, Kakinoki S, Yonezawa K, Himura Y, Yokota I, Yamamoto K, Tsuchihashi-Makaya M, Kinugawa S

J Cardiol   79 ( 6 )   719 - 726   2021年6月

Impact of Inadequate Calorie Intake on Mortality and Hospitalization in Stable Patients with Chronic Heart Failure 査読

Yoshikuni Obata, Naoya Kakutani, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shingo Takada, Taisuke Ono, Takeshi Sota, Yoshiharu Kinugasa, Masashige Takahashi, Hisashi Matsuo, Ryuichi Matsukawa, Ichiro Yoshida, Isao Yokota, Kazuhiro Yamamoto, Miyuki Tsuchihashi-Makaya

Nutrients   13 ( 3 )   874 - 874   2021年3月

Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ - Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure. 査読 国際誌

14 ( 1 )   e005890   2021年1月

Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction. 査読 国際誌

Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai

Cardiovascular diabetology   19 ( 1 )   142 - 142   2020年9月

Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. 査読 国際誌

Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Masaya Tsuda, Akimichi Saito, Arata Fukushima, Takashi Yokota, Junko Nio-Kobayashi, Hironobu Yasui, Kei Higashikawa, Yuji Kuge, Toshihisa Anzai, Hisataka Sabe, Shintaro Kinugawa

Cardiovascular research   117 ( 3 )   805 - 819   2020年5月

Angiotensin-converting-enzym inhibitor prevents skeletal uscle fibrosis in myocardial infarction mice 国際誌

Kakutani N, Takada S, Nambu H, Matsumoto J, Furihata T, Yokota T, Fukushima A, Kinugawa S

Skelet Muscle   2020年4月

Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter. 査読 国際誌

Eriko Kawamura, Minako Maruyama, Jiro Abe, Akira Sudo, Atsuhito Takeda, Shingo Takada, Takashi Yokota, Shintaro Kinugawa, Hideyoshi Harashima, Yuma Yamada

Molecular therapy. Nucleic acids   20   687 - 698   2020年4月

The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice. 査読 国際誌

Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Naoya Kakutani, Takaaki Furihata, Mochamad Ali Sobirin, Arata Fukushima, Yoshikuni Obata, Akimichi Saito, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

Experimental physiology   105 ( 3 )   489 - 501   2020年3月

Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle. 査読 国際誌

Maekawa S, Takada S, Furihata T, Fukushima A, Yokota T, Kinugawa S

Biochemistry and biophysics reports   21   100717 - 100717   2020年3月

Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy. 査読 国際誌

Katsuma Yamanashi, Shintaro Kinugawa, Arata Fukushima, Naoya Kakutani, Shingo Takada, Yoshikuni Obata, Ippei Nakano, Takashi Yokota, Yasuyuki Kitaura, Yoshiharu Shimomura, Toshihisa Anzai

Life sciences   117593 - 117593   2020年3月

Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates doxorubicin-induced cardiotoxicity in mice. 査読 国際誌

Yoshikuni Obata, Naoki Ishimori, Akimichi Saito, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Ippei Nakano, Naoya Kakutani, Katsuma Yamanashi, Toshihisa Anzai

European journal of preventive cardiology   27 ( 19 )   2047487319901208 - 2047487319901208   2020年3月

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure. 査読

Ippei Nakano, Shintaro Kinugawa, Hiroaki Hori, Arata Fukushima, Takashi Yokota, Shingo Takada, Naoya Kakutani, Yoshikuni Obata, Katsuma Yamanashi, Toshihisa Anzai

International heart journal   61 ( 1 )   96 - 102   2020年1月

Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure. 査読 国際誌

Ippei Nakano, Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Naoya Kakutani, Shingo Takada, Takashi Yokota

Journal of cardiology   76 ( 1 )   109 - 114   2020年1月

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. 査読 国際誌

Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S

European journal of pharmacology   866   172810 - 172810   2020年1月

Standard cardiac rehabilitation program for heart failure 査読 国際誌

Izawa H, Yoshida T, Ikegami T, Izawa KP, Ito Y, Okamura H, Osada N, Kinugawa S, Kubozono T, Kono Y, Kobayashi K, Nishigaki K, Higo T, Hirashiki A, Miyazawa Y, Morio Y, Yanase M, Yamada S, Ikeda H, Momomura SI, Kihara Y, Yamamoto K, Goto Y, Makita S; Japanese Association of Cardiac Rehabilitation Standard Cardiac Rehabilitation Program Planning Committee

Circ J   83 ( 12 )   2394 - 2398   2019年12月

Long-term treatment of tolvaptan in refractory heart failure 査読 国際誌

Imamura T, Kinugawa S, Muramatsu T, Shiga T, Ogimoto A, Anzai T, Hagiwara N, Tsutsui H, Komuro I, Kinugawa K

Circ Rep   1 ( 10 )   431 - 437   2019年10月

Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. 査読

Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T

Scientific reports   9 ( 1 )   14709   2019年10月

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. 査読 国際誌

Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S

Cell communication and signaling : CCS   17 ( 1 )   128 - 128   2019年10月

Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure. 査読 国際誌

Nakano I, Hori H, Fukushima A, Yokota T, Kinugawa S, Takada S, Yamanashi K, Obata Y, Kitaura Y, Kakutani N, Abe T, Anzai T

Journal of cardiac failure   26 ( 8 )   685 - 693   2019年9月

JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version. 査読

Tsutsui H, Isobe M, Ito H, Okumura K, Ono M, Kitakaze M, Kinugawa K, Kihara Y, Goto Y, Komuro I, Saiki Y, Saito Y, Sakata Y, Sato N, Sawa Y, Shiose A, Shimizu W, Shimokawa H, Seino Y, Node K, Higo T, Hirayama A, Makaya M, Masuyama T, Murohara T, Momomura SI, Yano M, Yamazaki K, Yamamoto K, Yoshikawa T, Yoshimura M, Akiyama M, Anzai T, Ishihara S, Inomata T, Imamura T, Iwasaki YK, Ohtani T, Onishi K, Kasai T, Kato M, Kawai M, Kinugasa Y, Kinugawa S, Kuratani T, Kobayashi S, Tanaka A, Toda K, Noda T, Nochioka K, Hatano M, Hidaka T, Fujino T, Makita S, Yamaguchi O, Ikeda U, Kimura T, Kohsaka S, Kosuge M, Yamagishi M, Yamashina A, Japanese Circulation Society, the Japanese Heart Failure Society Joint, Working Group

Circulation Journal   83 ( 10 )   2084 - 2184   2019年9月

Heterogeneity in the vasodilatory function of individual extremities 査読

Kadoguchi T, Horiuchi M, Kinugawa S, Okita K

Vascular   doi: 10.1177/1708538119868411   2019年8月

A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. 査読

Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y

Mitochondrion   49   66 - 72   2019年7月

Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial -

Hiroyuki Tsutsui, Shin-ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa, Koji Oba, Norihiro Sato, Yoshio Yasumura, Shinya Hiramitsu, Yukihito Satou, Takayuki Inomata, Katsuya Onishi, Yasushi Sakata, Kyoichi Mizuno, Kenji Sunagawa, Hisao Ogawa, Mitsuaki Isobe, Hiroyuki Daida, Masahiko Kurabayashi, Shintaro Kinugawa, Tetsuro Kohya, Yuji Ogawa, Naofumi Itoh, Shigeo Kakinoki, Kenji Aoki, Akihito Tsuchida, Hiroshi Ito, Osamu Yamaguchi, Yutaka Eki, Shigeru Toyoda, Akihiko Nakano, Norimichi Koitabashi, Toshihiro Muramatsu, Hideo Nakahara, Hiroyuki Tanaka, Akira Yamashina, Kiyoshi Takasu, Yasuhiro Maejima, Yukihiko Momiyama, Iwao Nakamura, Keisuke Kida, Takashi Naruke, Hideshi Takenobu, Tohru Minamino, Masahiko Nakamura, Masatoshi Ikeda, Kazuhiro Ashida, Shigekiyo Takahashi, Shinya Minatoguchi, Satoru Suwa, Hiroshi Satoh, Hideo Izawa, Hidekatsu Fukuta, Naoya Tsuboi, Hiroyasu Uzui, Atsuyuki Wada, Takeshi Kimura, Ken Takenaka, Takao Kato, Masaaki Okutsu, Tomohito Ohtani, Shinji Hasegawa, Toshihisa Anzai, Kenshi Fujii, Ichiro Shiojima, Yoshinori Yasaka, Tohru Masuyama, Ken-ichi Hirata, Yoshihiko Saito, Takashi Akasaka, Hiroshi Ito, Yasuki Kihara, Ritsu Tamura, Hiroki Teragawa, Kotaro Yasuda, Koichiro Okuhara, Eiji Karashima, Masataka Sata, Akira Ota, Takahisa Noma, Jun Suzuki, Kouki Watanabe, Hiroaki Kitaoka, Ryuichi Matsukawa, Takeshi Yoshihiro, Nobuhide Tanaka, Kiyoshi Ozumi, Masaru Takahashi, Koji Maemura, Nobuhiko Atsuchi

CIRCULATION JOURNAL   83 ( 6 )   1269 - +   2019年6月

Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms. 査読

Komoriyama H, Fukushima A, Takahashi Y, Kinugawa S, Sera F, Ohtani T, Nakamura A, Sakata Y, Anzai T

Internal medicine (Tokyo, Japan)   58 ( 17 )   2545 - 2549   2019年5月

Clinical impacts and associated factors of delayed ambulation in patients with acute heart failure 査読 国際誌

Ishikawa K, Fukushima A, Yokota T, Takada S, Furihata T, Kakutani N, Yamanashi K, Obata Y, Nakano I, Abe T, Kinugawa S, Anzai T

Circ Rep   1 ( 4 )   179 - 186   2019年4月

Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. 査読 国際誌

Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S

Scientific reports   9 ( 1 )   3535 - 3535   2019年3月

Progressive mobilization program for patients with acute heart failure reduces the hospital stay and improves clinical outcomes 査読 国際誌

Kakutani N, Fukushima A, Kinugawa S, Yokota T, Oikawa T, Nishikawa M, Nakamura R, Tsukada T, Mori S, Yoshida I, Anzai T

Circ Rep   1 ( 3 )   123 - 130   2019年3月

Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder 査読 国際誌

Li M, Hirano K, Ikeda Y, Higashi M, Hashimoto C, Zhang B, Kozawa J, Sugimura K, Miyauchi H, Suzuki A, Hara Y, Takagi A, Ikeda Y, Kobayashi K, Futsukaichi Y, Zaima N, Yamaguchi S, Shrestha R, Nakamura H, Kawaguchi K, Sai E, Hui SP, Nakano Y, Sawamura A, Inaba T, Sakata Y, Yasui Y, Nagasawa Y, Kinugawa S, Shimada K, Yamada S, Hao H, Nakatani D, Ide T, Amano T, Naito H, Nagasaka H, Kobayashi K, on behlf of the Japan TGCV study group

Orphanet J Rare Dis   14 ( 1 )   134   2019年1月

Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort 査読 国際誌

Okita K, Takada S, Morita N, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S

Appl Physiol Nutr Metab   2018 Dec 19 ( 7 )   759 - 764   2018年12月

Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure. 査読

Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T

Circulation   138 ( 18 )   2064 - 2066   2018年10月

Impact of High Respiratory Exchange Ratio During Submaximal Exercise on Adverse Clinical Outcome in Heart Failure 査読

Kakutani N, Fukushima A, Yokota T, Katayama T, Nambu H, Shirakawa R, Maekawa S, Abe T, Takada S, Furihata T, Ono K, Okita K, Kinugawa S, Anzai T

Circ J   2018年8月

Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure 査読

Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T

J Cachexia Sarcopenia Muscle   2018年8月

Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure. 査読

Fukuda H, Shindo K, Sakamoto M, Ide T, Kinugawa S, Fukushima A, Tsutsui H, Ito S, Ishii A, Washio T, Kitakaze M

EBioMedicine   33   185 - 195   2018年7月

Hyponatremia as a surrogate marker for optimal diuretic selection in acute heart failure. 査読

Fukushima A, Kinugawa S

Journal of cardiology   71 ( 6 )   547 - 549   2018年6月

Randomized trial of effect of urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia (LEAF-CHF): study design 査読 国際誌

Yokota T, Fukushima A, Kinugawa S, Okumura T, Murohara T, Tsutsui H

Int Heart J   59 ( 5 )   976 - 982   2018年5月

Malnutrition in Heart Failure: Important But Undervalued Issue. 査読

Kinugawa S, Fukushima A

JACC. Heart failure   2018年5月

The impact of creating mathematical formula to predict cardiovascular events in patients with heart failure. 査読

Sakamoto M, Fukuda H, Kim J, Ide T, Kinugawa S, Fukushima A, Tsutsui H, Ishii A, Ito S, Asanuma H, Asakura M, Washio T, Kitakaze M

Scientific reports   8 ( 1 )   3986   2018年3月

Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure 査読

Hiroyuki Sawatari, Mari K. Nishizaka, Mami Miyazono, Shin-ichi Ando, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Daisuke Goto, Tomoo Furumoto, Shintaro Kinugawa, Nobuko Hashiguchi, Anita Rahmawati, Hiroaki Chishaki, Tomoko Ohkusa, Chie Magota, Hiroyuki Tsutsui, Akiko Chishaki

Heart and Vessels   33 ( 2 )   155 - 162   2018年2月

Diagnostic criteria and severity score for triglyceraide deposit cardiomyovasculopathy 査読 国際誌

Miyauchi H, Hashimoto C, Ikeda Y, Li M, Nakano Y, Kozawa J, Sai E, Nagasawa Y, Kinugawa S, Kawaguchi K, Shimada K, Ide T, Amano T, Higashi M, Inaba T, Nakamura H, Kobayashi K, Hirano K

Ann Nucl Cardiol   4 ( 1 )   94 - 100   2018年1月

Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy 査読 国際誌

Kadoguchi T, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Mizushima W, Fukushima A, Okita K, Kinugawa S

Biomed Res Int   2018   3194917 - 3194917   2018年1月

Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome 査読

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Masashige Takahashi, Arata Fukushima, Shouji Matsushima, Mayumi Yamato, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF DIABETES INVESTIGATION   8 ( 4 )   535 - 541   2017年7月

Angiotensin II and skeletal muscle abnormalities 査読

Shintaro Kinugawa

EXPERIMENTAL PHYSIOLOGY   102 ( 6 )   614 - 615   2017年6月

Renin-Angiotensin-Aldosterone System and Natriuretic Peptides as Possible Targets of Waon Therapy in Heart Failure 査読

Arata Fukushima, Shintaro Kinugawa

CIRCULATION JOURNAL   81 ( 5 )   635 - 636   2017年5月

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes 査読

Wataru Mizushima, Hidehisa Takahashi, Masashi Watanabe, Shintaro Kinugawa, Shouji Matsushima, Shingo Takada, Takashi Yokota, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Ikuru Chiba, Shun Nagashima, Shigeru Yanagi, Masaki Matsumoto, Keiichi I. Nakayama, Hiroyuki Tsutsui, Shigetsugu Hatakeyama

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   100   43 - 53   2016年11月

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure. 査読 国際誌

Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Takashi Yokota, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

International journal of cardiology   220   483 - 7   2016年10月

Fyn is a physiological regulator of Nox4 in the heart 査読 国際誌

Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J

J Clin Invest   126 ( 9 )   3403 - 3416   2016年9月

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling 査読

Shouji Matsushima, Junya Kuroda, Peiyong Zhai, Tong Liu, Shohei Ikeda, Narayani Nagarajan, Shin-ichi Oka, Takashi Yokota, Shintaro Kinugawa, Chiao-Po Hsu, Hong Li, Hiroyuki Tsutsui, Junichi Sadoshima

JOURNAL OF CLINICAL INVESTIGATION   126 ( 9 )   3403 - 3416   2016年9月

Successful Evaluation for Reversibility of Pulmonary Hypertension Using Inhaled Nitric Oxide Determining Candidate for Heart Transplantation 査読

Omote Kazunori, Sakakibara Mamoru, Nanbu Hideo, Maekawa Satoshi, Asakawa Naoya, Noguchi Keiji, Tokuda Yusuke, Kamiya Kiwamu, Kinugawa Shintaro, Tsutsui Hiroyuki

JOURNAL OF CARDIAC FAILURE   22 ( 9 )   S228 - S229   2016年9月

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling 査読

Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takaaki Furihata, Wataru Mizushima, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Masashige Takahashi, Shinichi Harashima, Shouji Matsushima, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsui

CARDIOVASCULAR RESEARCH   111 ( 4 )   338 - 347   2016年9月

The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice. 査読 国際誌

Takaaki Furihata, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Masashige Takahashi, Tsuneaki Homma, Yoshihiro Masaki, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Shouji Matsushima, Takashi Yokota, Hiroyuki Tsutsui

International journal of cardiology. Heart & vasculature   11   24 - 28   2016年6月

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice 査読

Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Junichi Matsumoto, Takaaki Furihata, Wataru Mizushima, Masaya Tsuda, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

EUROPEAN JOURNAL OF PHARMACOLOGY   779   147 - 156   2016年5月

Low-intensity exercise under ischemic conditions enhances metabolic stress in patients with heart failure 査読

Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Kagami Hirabayashi, Takashi Yokota, Shouji Matsushima, Akimichi Saito, Koichi Okita, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   201   142 - 144   2015年12月

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes 査読

Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Daisuke Takemoto, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Yoshiko Ono, Hiroshi Shibata, Koichi Okita, Hiroyuki Tsutsui

EXPERIMENTAL PHYSIOLOGY   100 ( 11 )   1319 - 1330   2015年11月

Curcumin ameliorates skeletal muscle atrophy in type 1 diabetic mice by inhibiting protein ubiquitination 査読

Taisuke Ono, Shingo Takada, Shintaro Kinugawa, Hiroyuki Tsutsui

EXPERIMENTAL PHYSIOLOGY   100 ( 9 )   1052 - 1063   2015年9月

Skeletal Muscle Abnormalities in Heart Failure 査読

Shintaro Kinugawa, Shingo Takada, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

INTERNATIONAL HEART JOURNAL   56 ( 5 )   475 - 484   2015年9月

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress 査読

Mikito Nishikawa, Naoki Ishimori, Shingo Takada, Akimichi Saito, Tomoyasu Kadoguchi, Takaaki Furihata, Arata Fukushima, Shouji Matsushima, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

NEPHROLOGY DIALYSIS TRANSPLANTATION   30 ( 6 )   934 - 942   2015年6月

Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure. 査読 国際誌

Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takashi Yokota, Shouji Matsushima, Shingo Takada, Tomoyasu Kadoguchi, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

Journal of cardiac failure   21 ( 4 )   300 - 6   2015年4月

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle 査読

Tomoyasu Kadoguchi, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Takaaki Furihata, Tsuneaki Homma, Yoshihiro Masaki, Wataru Mizushima, Mikito Nishikawa, Masashige Takahashi, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

EXPERIMENTAL PHYSIOLOGY   100 ( 3 )   312 - 322   2015年3月

Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity 査読

Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Arata Fukushima, Tadashi Suga, Masashige Takahashi, Taisuke Ono, Noriteru Morita, Masashi Omokawa, Kuniaki Harada, Noriko Oyama-Manabe, Hiroaki Shirato, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   176 ( 3 )   1110 - 1112   2014年10月

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice 査読

Shingo Takada, Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Shouji Matsushima, Tadashi Suga, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Wataru Mizushima, Yoshihiro Masaki, Takaaki Furihata, Ryoichi Katsuyama, Koichi Okita, Hiroyuki Tsutsui

EUROPEAN JOURNAL OF PHARMACOLOGY   740   690 - 696   2014年10月

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice 査読

Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Shouji Matsushima, Mochamad Ali Sobirin, Taisuke Ono, Masashige Takahashi, Tadashi Suga, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM   307 ( 6 )   E503 - E514   2014年9月

Clinical characteristics and CHADS(2) score in patients with heart failure and atrial fibrillation: Insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Shintaro Kinugawa, Shouji Matsushima, Arata Fukushima, Takashi Yokota, Mamoru Sakakibara, Hisashi Yokoshiki, Miyuki Tsuchihashi-Makaya, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   176 ( 1 )   239 - 242   2014年9月

Assessment of Quality of Life During Long-Term Treatment of Tolvaptan in Refractory Heart Failure Design and Rationale of the AQUA-TLV Study 査読

Teruhiko Imamura, Koichiro Kinugawa, Tomohito Ohtani, Yasushi Sakata, Taiki Higo, Shintaro Kinugawa, Hiroyuki Tsutsui, Kenji Sunagawa, Issei Komuro

INTERNATIONAL HEART JOURNAL   55 ( 3 )   264 - 267   2014年5月

Weekend versus weekday hospital admission and outcomes during hospitalization for patients due to worsening heart failure: a report from Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Hiroyuki Tsutsui

HEART AND VESSELS   29 ( 3 )   328 - 335   2014年5月

Hyponatremia is an independent predictor of adverse clinical outcomes in hospitalized patients due to worsening heart failure 査読

Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Shouji Matsushima, Mamoru Sakakibara, Naoki Ishimori, Daisuke Goto, Hiroyuki Tsutsui

JOURNAL OF CARDIOLOGY   63 ( 3-4 )   182 - 188   2014年3月

Combination of Exercise Training and Diet Restriction Normalizes Limited Exercise Capacity and Impaired Skeletal Muscle Function in Diet-Induced Diabetic Mice 査読

Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A. Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsui

ENDOCRINOLOGY   155 ( 1 )   68 - 80   2014年1月

Report of the American Heart Association (AHA) Scientific Sessions 2013, Dallas 査読

Naoki Ishimori, Shintaro Kinugawa, Satoshi Yamada, Hisashi Yokoshiki, Hirofumi Mitsuyama, Hiroyuki Tsutsui

CIRCULATION JOURNAL   78 ( 1 )   51 - 56   2014年1月

Resistance exercise with blood flow restriction in women 招待 査読

Okita K, Takada S, Suga T, Kadoguchi T, Taniura T, Morita N, Yokota T, Kinugawa S, Tsutsui H

Proceeding of Asian Federation of Sports Medicine   73 - 75   2013年12月

Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy 査読

Takashi Fujita, Noboru Fujino, Ryuichiro Anan, Chuwa Tei, Toru Kubo, Yoshinori Doi, Shintaro Kinugawa, Hiroyuki Tsutsui, Shigeki Kobayashi, Masafumi Yano, Masanori Asakura, Masafumi Kitakaze, Issei Komuro, Tetsuo Konno, Kenshi Hayashi, Masa-aki Kawashiri, Hidekazu Ino, Masakazu Yamagishi

JACC-HEART FAILURE   1 ( 6 )   459 - 466   2013年12月

Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure. 査読 国際誌

Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takashi Yokota, Shouji Matsushima, Takahiro Abe, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Ryoichi Katsuyama, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

International journal of cardiology   168 ( 5 )   e142-4 - 4   2013年10月

Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure 査読

Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Takahiro Abe, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Shouji Matsushima, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   168 ( 4 )   4313 - 4314   2013年10月

Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice. 査読

62   179 - 188   2013年9月

Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

JOURNAL OF CARDIOLOGY   62 ( 1-2 )   95 - 101   2013年7月

Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome 査読

Takashi Yokota, Shintaro Kinugawa, Mayumi Yamato, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Kuniaki Harada, Noriteru Morita, Noriko Oyama-Manabe, Yasuka Kikuchi, Koichi Okita, Hiroyuki Tsutsui

DIABETES CARE   36 ( 5 )   1341 - 1346   2013年5月

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice 査読

Shingo Takada, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Mochamad A. Sobirin, Yoshihiro Masaki, Wataru Mizushima, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF APPLIED PHYSIOLOGY   114 ( 7 )   844 - 857   2013年4月

Home-Based Disease Management Program to Improve Psychological Status in Patients With Heart Failure in Japan 査読

Miyuki Tsuchihashi-Makaya, Hisashi Matsuo, Shigeo Kakinoki, Shigeru Takechi, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION JOURNAL   77 ( 4 )   926 - 933   2013年4月

Exercise Intolerance in Chronic Heart Failure - Skeletal Muscle Dysfunction and Potential Therapies 査読

Koichi Okita, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION JOURNAL   77 ( 2 )   293 - 300   2013年2月

Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: Report from the registry data in Japan 査読

Daisuke Goto, Shintaro Kinugawa, Sanae Hamaguchi, Mamoru Sakakibara, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

JOURNAL OF CARDIOLOGY   61 ( 1-2 )   65 - 70   2013年1月

[Multidisciplinary management for heart failure --prevention, diagnosis and updated treatment]. 査読

Yokoshiki H, Tsutsui H, Goto D, Kinugawa S, Ooka T

[Hokkaido igaku zasshi] The Hokkaido journal of medical science   88 ( 1 )   11 - 14   2013年1月

Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction 査読

Tadashi Suga, Koichi Okita, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Yokota, Kagami Hirabayashi, Masashige Takahashi, Noriteru Morita, Masahiro Horiuchi, Shintaro Kinugawa, Hiroyuki Tsutsui

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   112 ( 11 )   3915 - 3920   2012年11月

Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice 査読

Mochamad Ali Sobirin, Shintaro Kinugawa, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Putri Azalia, Shingo Takada, Masaru Taniguchi, Toshinori Nakayama, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

CIRCULATION RESEARCH   111 ( 8 )   1037 - +   2012年9月

Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   76 ( 8 )   1920 - 1927   2012年8月

Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions 査読

Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Sato, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Noriteru Morita, Masahiro Horiuchi, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF APPLIED PHYSIOLOGY   113 ( 2 )   199 - 205   2012年7月

Mode of Death in Patients With Heart Failure and Reduced vs. Preserved Ejection Fraction - Report From the Registry of Hospitalized Heart Failure Patients 査読

Sanae Hamaguchi, Shintaro Kinugawa, Mochamad Ali Sobirin, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

CIRCULATION JOURNAL   76 ( 7 )   1662 - 1669   2012年7月

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle 査読

Naoki Inoue, Shintaro Kinugawa, Tadashi Suga, Takashi Yokota, Kagami Hirabayashi, Satoshi Kuroda, Koichi Okita, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   302 ( 5 )   H1202 - H1210   2012年3月

Blood Flow Restriction Exercise in Sprinters and Endurance Runners 査読

Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Noriteru Morita, Masahiro Horiuchi, Tomoyasu Kadoguchi, Masashige Takahashi, Kagami Hirabayashi, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   44 ( 3 )   413 - 419   2012年3月

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice 査読

Mayumi Yamato, Takeshi Shiba, Tomomi Ide, Naoko Seri, Wataru Kudo, Makoto Ando, Ken-ichi Yamada, Shintaro Kinugawa, Hiroyuki Tsutsui

MOLECULAR AND CELLULAR BIOCHEMISTRY   359 ( 1-2 )   161 - 167   2012年1月

Oxidative stress and heart failure 査読

Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   301 ( 6 )   H2181 - H2190   2011年12月

[Inotropic drug]. 査読

Kinugawa S

Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 9   397 - 401   2011年11月

Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Shintaro Kinugawa, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   75 ( 10 )   2403 - 2410   2011年10月

Hyperuricemia predicts adverse outcomes in patients with heart failure 査読

Sanae Hamaguchi, Tomoo Furumoto, Miyuki Tsuchihashi-Makaya, Kazutomo Goto, Daisuke Goto, Takashi Yokota, Shintaro Kinugawa, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   151 ( 2 )   143 - 147   2011年9月

Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome 査読

Takashi Yokota, Shintaro Kinugawa, Koichi Okita, Kagami Hirabayashi, Tadashi Suga, Masaaki Hattori, Yoshinao Nakagawa, Noriko Oyama-Manabe, Hiroki Shirato, Hiroyuki Tsutsui

HYPERTENSION RESEARCH   34 ( 9 )   1029 - 1034   2011年9月

Sex differences with respect to clinical characteristics, treatment, and long-term outcomes in patients with heart failure 査読

Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Kazutomo Goto, Daisuke Goto, Tomoo Furumoto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

INTERNATIONAL JOURNAL OF CARDIOLOGY   150 ( 3 )   338 - 339   2011年8月

Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure 査読

Yukihiro Ohta, Shintaro Kinugawa, Shouji Matsushima, Taisuke Ono, Mochamad A. Sobirin, Naoki Inoue, Takashi Yokota, Kagami Hirabayashi, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   300 ( 5 )   H1637 - H1644   2011年5月

Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus 査読

Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima, Takashi Yokota

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   48 ( 1 )   68 - 71   2011年1月

Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Takashi Yokota, Kazutomo Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   74 ( 12 )   2605 - 2611   2010年12月

Spironolactone use at discharge was associated with improved survival in hospitalized patients with systolic heart failure 査読

Sanae Hamaguchi, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Kazutomo Goto, Daisuke Goto, Takashi Yokota, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

AMERICAN HEART JOURNAL   160 ( 6 )   1156 - 1162   2010年12月

Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure - Report From MetS-CHF Study 査読

Yutaka Miura, Yoshihiro Fukumoto, Nobuyuki Shiba, Toshiro Miura, Kazunori Shimada, Yoshitaka Iwama, Atsutoshi Takagi, Hidenori Matsusaka, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Masanori Asakura, Shuichi Okamatsu, Hiroyuki Tsutsui, Hiroyuki Daida, Masunori Matsuzaki, Hitonobu Tomoike, Hiroaki Shimokawa

CIRCULATION JOURNAL   74 ( 12 )   2612 - 2621   2010年12月

Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation o2 of calf muscle during plantar flexion exercise 査読 国際誌

Horiuchi M, Okita K, Takada S, Omokawa M, Suga T, Morita N, Hirabayashi K, Yokota T, Kinguawa S, Tsutsui H

Adv Exp Med Biol   662   531 - 536   2010年10月

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice 査読

Masaaki Hokari, Satoshi Kuroda, Shintaro Kinugawa, Tomomi Ide, Hiroyuki Tsutsui, Yoshinobu Iwasaki

NEUROPATHOLOGY   30 ( 4 )   401 - 407   2010年8月

Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism 査読

Caroline Ojaimi, Shintaro Kinugawa, Fabio A. Recchia, Thomas H. Hintze

CARDIOVASCULAR DIABETOLOGY   9   43   2010年8月

Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival 査読

Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Hisashi Yokoshiki, Sanae Hamaguchi, Takashi Yokota, Daisuke Goto, Kazutomo Goto, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   74 ( 7 )   1364 - 1371   2010年7月

Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction 査読

Tadashi Suga, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Masashi Omokawa, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF APPLIED PHYSIOLOGY   108 ( 6 )   1563 - 1567   2010年6月

[Myocardial ischemia and metabolic disorder]. 査読

Yokota T, Kinugawa S, Tsutsui H

Nihon rinsho. Japanese journal of clinical medicine   68 ( 4 )   621 - 624   2010年4月

Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure 査読

Miyuki Tsuchihashi-Makaya, Tomoo Furumoto, Shintaro Kinugawa, Sanae Hamaguchi, Kazutomo Goto, Daisuke Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui

HYPERTENSION RESEARCH   33 ( 3 )   197 - 202   2010年3月

Clinical characteristics and outcomes of heart failure with preserved ejection fraction: Lessons from epidemiological studies 査読

Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa

JOURNAL OF CARDIOLOGY   55 ( 1 )   13 - 22   2010年1月

Effects of Atrial Fibrillation on Long-Term Outcomes in Patients Hospitalized for Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Hisashi Yokoshiki, Shintaro Kinugawa, Miyuki Tsuchihashi-Makaya, Takashi Yokota, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   73 ( 11 )   2084 - 2090   2009年11月

Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Takashi Yokota, Akira Takeshita, Hisashi Yokoshiki, Hiroyuki Tsutsui

CIRCULATION JOURNAL   73 ( 10 )   1901 - 1908   2009年10月

Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Hisashi Yokoshiki, Norihiro Kato, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   73 ( 10 )   1893 - 1900   2009年10月

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice 査読

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Shouji Matsushima, Naoki Inoue, Yukihiro Ohta, Sanae Hamaguchi, Mochamad A. Sobirin, Taisuke Ono, Tadashi Suga, Satoshi Kuroda, Shinya Tanaka, Fumio Terasaki, Koichi Okita, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 3 )   H1069 - H1077   2009年9月

Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan - Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) - 査読

Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Takashi Yokota, Tomomi Ide, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   73 ( 8 )   1442 - 1447   2009年8月

Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes 査読

Shouji Matsushima, Shintaro Kinugawa, Takashi Yokota, Naoki Inoue, Yukihiro Ohta, Sanae Hamaguchi, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 1 )   H409 - H416   2009年7月

Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction 査読

Tadashi Suga, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Tomohiro Takahashi, Masashi Omokawa, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF APPLIED PHYSIOLOGY   106 ( 4 )   1119 - 1124   2009年4月

Mitochondrial oxidative stress and dysfunction in myocardial remodelling 査読

Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima

CARDIOVASCULAR RESEARCH   81 ( 3 )   449 - 456   2009年2月

Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin 査読

Mayumi Yamato, Takeshi Shiba, Masayoshi Yoshida, Tomomi Ide, Naoko Seri, Wataru Kudou, Shintaro Kinugawa, Hiroyuki Tsutsui

FEBS JOURNAL   274 ( 15 )   3855 - 3863   2007年8月

Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart 査読

Hiroyuki Tsutsui, Shouji Matsushima, Shintaro Kinugawa, Tomomi Ide, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Sanae Hamaguchi, Kenji Sunagawa

HYPERTENSION RESEARCH   30 ( 5 )   439 - 449   2007年5月

[Diabetic heart disease]. 査読

Kinugawa S

Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 5   465 - 469   2007年5月

Characteristics and outcomes of patients with heart failure in general practices and hospitals - Japanese cardiac registry of heart failure in general practice (JCARE-GENERAL) 査読

Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

CIRCULATION JOURNAL   71 ( 4 )   449 - 454   2007年4月

[Molecular mechanisms of chronic heart failure]. 査読

Kinugawa S, Tsutsui H

Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 4   87 - 91   2007年4月

[Recovery from circulatory support with long term left ventricular assist device in a 29-year-old woman with fulminant giant cell myocarditis]. 査読

Hirabayashil K, Yamada S, Iwamil K, Kinugawa S, Makita N, Okamotol H, Sugiki H, Murashita T, Nakagawa Y, Tsutsui H

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   96 ( 2 )   335 - 337   2007年2月

Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress 査読

Nobuhiro Suematsu, Caroline Ojaimi, Shintaro Kinugawa, Zipping Wang, Xiaobin Xu, Akos Koller, Fabio A. Recchia, Thomas H. Hintze

CIRCULATION   115 ( 2 )   255 - 262   2007年1月

Clinical characteristics and outcome of hospitalized patients with heart failure in Japan - Rationale and design of Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) 査読

Hiroyuki Tsutsui, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

CIRCULATION JOURNAL   70 ( 12 )   1617 - 1623   2006年12月

Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart 査読

Shouji Matsushima, Shintaro Kinugawa, Tomomi Ide, Hidenori Matsusaka, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Kenji Sunagawa, Hiroyuki Tsutsui

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   291 ( 5 )   H2237 - H2245   2006年11月

Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction 査読

Hidenori Matsusaka, Shintaro Kinugawa, Tomomi Ide, Shouji Matsushima, Tetsuya Shiomi, Toru Kubota, Kenji Sunagawa, Hiroyuki Tsutsui

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   48 ( 3 )   95 - 102   2006年9月

Mitochondrial oxidative stress, DNA damage, and heart failure 査読

Hiroyuki Tsutsui, Tomomi Ide, Shintaro Kinugawa

ANTIOXIDANTS & REDOX SIGNALING   8 ( 9-10 )   1737 - 1744   2006年9月

Targeted deletion of p53 prevents cardiac rapture after myocardial infarction in mice 査読

H Matsusaka, T Ide, S Matsushima, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

CARDIOVASCULAR RESEARCH   70 ( 3 )   457 - 465   2006年6月

[Oxidative stress and heart failure]. 査読

Kinugawa S, Tsutsui H

Nihon rinsho. Japanese journal of clinical medicine   64 ( 5 )   848 - 853   2006年5月

Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice 査読

S Matsushima, T Ide, M Yamato, H Matsusaka, F Hattori, M Ikeuchi, T Kubota, K Sunagawa, Y Hasegawa, T Kurihara, S Oikawa, S Kinugawa, H Tsutsui

CIRCULATION   113 ( 14 )   1779 - 1786   2006年4月

Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload 査読

H Matsusaka, T Ide, S Matsushima, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

HYPERTENSION   47 ( 4 )   711 - 717   2006年4月

Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype 査読

C Ojaimi, W Li, S Kinugawa, H Post, A Csiszar, P Pacher, G Kaley, TH Hintze

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   289 ( 4 )   H1399 - H1407   2005年10月

[Ca channel blocker and heart failure]. 査読

Kinugawa S, Tsutsui H

Clinical calcium   15 ( 10 )   1615 - 1622   2005年10月

gp91(phox)-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II 査読

S Kinugawa, JH Zhang, E Messina, E Walsh, H Huang, PM Kaminski, MS Wolin, TH Hintze

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   289 ( 2 )   H862 - H867   2005年8月

Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice - Roles of superoxide anion and nitric oxide 査読

S Kinugawa, ZP Wang, PM Kaminski, MS Wolin, JG Edwards, G Kaley, TH Hintze

CIRCULATION   111 ( 12 )   1480 - 1486   2005年3月

A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase 査読

S Kinugawa, H Huang, ZP Wang, PM Kaminski, MS Wolin, TH Hintze

CIRCULATION RESEARCH   96 ( 3 )   355 - 362   2005年2月

Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes - The role of angiotensin II type 1 receptor and NAD(P)H oxidase 査読

S Kinugawa, H Post, PM Kaminski, XP Zhang, XB Xu, H Huang, FA Recchia, M Ochoa, MS Wolin, G Kaley, TH Hintze

CIRCULATION   108 ( 23 )   2934 - 2940   2003年12月

Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction 査読

S Hayashidani, H Tsutsui, T Shiomi, N Suematsu, S Kinugawa, T Ide, J Wen, A Takeshita

CIRCULATION   105 ( 7 )   868 - 873   2002年2月

Effects of ACE inhibition on left ventricular failure and oxidative stress in Dahl salt-sensitive rats 査読 国際誌

Tsutsui H, Ide T, Hayashidani S, Kinugawa S, Suematsu N, Utsumi H, Takeshita A

J Cardiovasc Pharmacol   37 ( 6 )   725 - 733   2001年6月

Alpha1-Adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts 査読 国際誌

Suematsu N, Satoh S, Kinugawa S, Tsutsui H, Hayashidani S, Nakamura R, Egashira K, Makino N, Takeshita A

Am J Physiol Heart Circ Physiol   281 ( 2 )   637 - 646   2001年6月

Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes 査読 国際誌

Tsutsui H, Kinugawa S, Ide T, Hayashidani S, Suematsu N, Satoh S, Nakamura R, Egashira K, Takeshita A

J Cardiovasc Pharmacol   37 ( 1 )   16 - 24   2001年1月

Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress 査読 国際誌

Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, Utsumi H, Takeshita A

Circ Res   87 ( 5 )   392 - 398   2000年2月

Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium 査読 国際誌

Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A

Circ Res   86 ( 2 )   152 - 157   2000年1月

Adrenoceptor-mediated regulation of myofibrillar Ca2+ sensitivity through the GTP-binding protein-related mechanisms: tension recording in beta-escin-skinned single rat cardiac cells with preserved receptor functions 査読 国際誌

Satoh S, Kinugawa S, Tsutsui H, Takeshita A

Pflugers Arch-Eur J Physiol   437 ( 5 )   702 - 709   1999年5月

Endocardial versus epicardial differences of sarcoplasmic reticulum Ca2+-ATPase gene expression in the canine failing myocardium 査読 国際誌

Igarashi-Saito K, Tsutsui H, Takahashi M, Kinugawa S, Egashira K, Takeshita A

Basic Res Cardiol   94 ( 4 )   267 - 273   1999年4月

Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action 査読 国際誌

Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A

Circulation   100 ( 7 )   690 - 692   1999年3月

Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocytes contractile dysfunction in heart failure 査読 国際誌

Kinugawa S, Tsutsui H, Satoh S, Takahashi M, Ide T, Igarashi-Saito K, Arimura K, Egashira K, Takeshita A

Cardiovasc Res   44 ( 2 )   398 - 406   1999年2月

Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes 査読 国際誌

9. Kinugawa S, Tsutsui H, Ide T, Nakamura R, Arimura K, Egashira K, Takeshita A

Cardiovasc Res   43 ( 1 )   157 - 164   1999年1月

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium 査読 国際誌

Ide T, Tsutsui H, Kinugawa S, Ustumi H, Kang D, Hattori N, Uchida K, Arimura K, Egashira K, Takeshita A

Circ Res   85 ( 4 )   357 - 363   1999年1月

Role of SR Ca2+-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure 査読

K Igarashi-Saito, H Tsutsui, S Yamamoto, M Takahashi, S Kinugawa, H Tagawa, M Usui, M Yamamoto, K Egashira, A Takeshita

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   275 ( 1 )   H31 - H40   1998年7月

Role of microtubles in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy 査読 国際誌

Takahashi M, Tsutsui H, Kinugawa S, Igarashi-Saito K, Yamamoto S, Yamamoto M, Tagawa H, Imanaka-Yoshida K, Egashira K, Takeshita A

J Mol Cell Cardiol   30 ( 5 )   1047 - 1057   1998年5月

Negative inotropic effect of basic fibroblast growth factor on adult rat cardiac myocytes 査読 国際誌

Ishibashi Y, Urabe Y, Tsutsui H, Kinugawa S, Sugimachi M, Takahashi M, Yamamoto S, Tagawa H, Sunagawa K, Takeshita A

Circulation   96 ( 8 )   2501 - 2504   1997年2月

HFrEF患者の薬物療法　一からわかる循環器腎臓病学（伊藤浩編）

絹川真太郎、筒井裕之（ 担当： 共著）

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高齢者HFpEF患者の臨床的特徴とどのように診断するかに関して教えてください　高齢者の循環器診療Q&A（伊藤浩編）

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日本医事新報社  2021年3月 

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医学書院  2021年1月 

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絹川真太郎（ 担当： 共著）

南江堂  2020年7月 

Comprehensive Cardiac Rehabilitation: Update of Non-Pharmacological Therapy for Heart Failure.

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2020年4月 

心不全における骨格筋エネルギー代謝異常 招待

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日本心不全学会学術集会  2022年10月 

心不全治療の最新トピックスと当院での取り組み 招待

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日本心不全学会学術集会  2022年10月 

Skeletal muscle abnormalities and myokines in heart failure 招待

2022年3月 

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日本病態栄養学会年次集会  2022年1月 

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絹川真太郎

日本循環器学会九州地方会  2021年12月 

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高田真吾、佐邊壽孝、絹川真太郎

日本生化学学会大会  2021年11月 

マイオカインとミトコンドリア：加齢や疾患における摂動

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日本生化学学会大会  2021年11月 

心不全治療アルゴリズム 招待

絹川真太郎

日本心不全学会学術集会  2021年10月 

心不全治療アップデート－新規治療法の位置づけ－ 招待

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日本心臓学会学術集会  2021年9月 

心疾患の超急性期における骨格筋異常発症機序 招待

高田真吾、絹川真太郎

日本心臓リハビリテーション学会学術集会  2021年6月 

高齢心疾患患者に対する心臓リハビリテーションのエビデンス 招待

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日本心臓リハビリテーション学会学術集会  2021年6月 

心不全と骨格筋の基礎 招待

絹川真太郎

日本心臓リハビリテーション学会学術集会  2021年6月 

Treatment with brain-derived neurotrophic factor (BDNF) for skeletal muscle abnormalities in heart failure 招待

2021年3月 

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Asian Pacific Society of Cardiology Japan Circulation Society 2020  2020年3月 

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日本心臓リハビリテーション学会学術集会  2020年7月 

Skeletal muscle as a therapeutic target 招待

Kinugawa Shintaro

2020年7月 

運動療法代替治療法の開発 招待

絹川真太郎

日本臨床運動療法学会学術集会  2020年9月 

Inadequate Nutritinal Intake is an Independent Predictor of Poor Outcomes in Patients with Heart Failure 招待

2019年3月 

ステージA、Bの運動療法の効果と実際 招待

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日本心不全学会学術集会  2019年10月 

心不全におけるマイオカインの役割 招待

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絹川真太郎、南部秀雄、高田真吾

日本酸化ストレス学会学術集会  2019年6月 

Treatment for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies 査読

Takada S, Sabe H, Kinugawa S

Am J Physiol Heart Circ Physiol   2022年2月

押さえておくべき心不全診療ガイドラインのポイント

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診断と治療   2020年6月

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2020年6月

Abnormalities of skeletal muscle, adipocyte tissue, and lipid metabolism in heart failure: practical therapeutic targets 査読

Takada S, Sabe H, Kinugawa S

Front Cardiovasc Med   2020年5月

循環不全や呼吸不全による臓器不全へ至るメカニズムとは？

絹川真太郎

2020年4月

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糖尿病プラクティス   2020年2月

Empagliflozin Restores Lowered Exercise Endurance Capacity via the Activation of Skeletal Muscle Fatty Acid Oxidation in Murine Heart Failure

Hideo Nambu, Shingo Takada, Satoshi Maekawa, Naoya Kakutani, Takaaki Furihata, Akimichi Saito, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa

CIRCULATION   2019年11月

重複障害を有する超高齢心疾患患者に対するリハビリテーションの工夫 難渋重症例をどのように対応するか? 後期高齢心不全患者に対する急性期離床プログラムの開発と運用

角谷 尚哉, 吉田 一郎, 福島 新, 中村 梨沙子, 塚田 貴紀, 絹川 真太郎, 安斉 俊久

日本循環器学会学術集会抄録集   2019年3月

在宅でのICTを活用した心不全患者向けセルフケア強化システムの開発・検証

髙田 真吾, 絹川 真太郎, 横田 卓

福田記念医療技術振興財団情報   2018年12月

Excessive Mitochondrial Reactive Oxygen Species Emission From Circulating Blood Cells is Associated With Systemic Oxidative Stress, Severity of Heart Failure, and Exercise Intolerance

Ryosuke Shirakawa, Takashi Yokota, Takayuki Nakajima, Shingo Takada, Miwako Yamane, Akimichi Saito, Satoshi Maekawa, Naoya Kakutani, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takashi Katayama, Hideo Nambu, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Arata Fukushima, Shintaro Kinugawa, Toshihisa Anzai

CIRCULATION   2018年11月

The Outer Mitochondrial Membrane Protein, mitoNEET, Sustains Structure of Mitochondrial Cristae

Takaaki Furihata, Shintaro Kinugawa, Shingo Takada, Satoshi Maekawa, Takashi Katayama, Ryosuke Shirakawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Naoya Kakutani, Akimichi Saito, Arata Fukushima, Takashi Yokota, Toshihisa Anzai

CIRCULATION   2018年11月

Inhibition of Xanthine Oxidase in the Acute Phase Preserves Mitochondrial Function in Skeletal Muscle and Exercise Capacity in Heart Failure After Myocardial Infarction

Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Ryosuke Shirakawa, Takashi Katayama, Katsuma Yamanashi, Yoshikuni Obata, Takaaki Furihata, Akimichi Saito, Takashi Yokota, Shintaro Kinugawa, Toshihisa Anzai

CIRCULATION   2018年11月

加齢に伴う運動能力低下・サルコペニアのバイオマーカーとしての血中アドロピンの臨床応用と基礎的検討

福島 新, 絹川 真太郎, 横田 卓, 高田 真吾, 沖田 孝一

デサントスポーツ科学   2018年5月

Coronary Artery Stenosis is Associated With Mitochondrial Dysfunction in Epicardial Adipose Tissue

Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihara, Shuhei Miura, Shingo Takada, Ryosuke Shirakawa, Takaaki Furihata, Masaya Tsuda, Junichi Matsumoto, Takashi Katayama, Arata Fukushima, Akimichi Saito, Yoshiro Matsui, Shintaro Kinugawa

CIRCULATION   2017年11月

High Respiratory Exchange Ratio at Submaximal Exercise Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure

Naoya Kakutani, Arata Fukushima, Takashi Yokota, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Takahiro Abe, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Shingo Takada, Akimichi Saito, Koichi Okita, Shintaro Kinugawa

CIRCULATION   2017年11月

Cardiac Hypertrophy in Congenital Heart Disease Delays the Maturation of Cardiac Fatty Acid B-Oxidation by Modifying Myocardial Acetylation Control(和訳中)

福島 新, 絹川 真太郎, 横田 卓, 齋藤 晶理, 高田 真吾, 降旗 高明, 松本 純一, 津田 正哉, 中島 孝之, 片山 貴史, 前川 聡, 南部 秀雄, 角谷 尚哉, 白川 亮介, 沖田 孝一, ポール・カンター, アイバン・レベッカ, ギャリー・ロパスチュック

日本循環器学会学術集会抄録集   2017年3月

The Novel Heart-specific RING-finger Protein 207 Modulates Energy Metabolism in Cardiomyocytes(和訳中)

高田 真吾, 水島 航, 降旗 高明, 松本 純一, 津田 正哉, 片山 貴史, 中島 孝之, 福島 新, 横田 卓, 絹川 真太郎

日本循環器学会学術集会抄録集   2017年3月

Skeletal Muscle Mitochondrial Protein Hyperacetylation Contributes to Exercise Intolerance in a Murine Model of Heart Failure After Myocardial Infarction(和訳中)

津田 正哉, 高田 真吾, 福島 新, 水島 航, 降旗 高明, 松本 純一, 片山 貴史, 中島 孝之, 白川 亮介, 前川 聡, 南部 秀雄, 角谷 尚哉, 横田 卓, 絹川 真太郎

日本循環器学会学術集会抄録集   2017年3月

Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis(和訳中)

中島 孝之, 横田 卓, 新宮 康栄, 山田 陽, 伊庭 裕, 若狭 哲, 大岡 智学, 高田 真吾, 白川 亮介, 降旗 高明, 津田 正哉, 松本 純一, 片山 貴史, 福島 新, 松居 喜郎, 絹川 真太郎

日本循環器学会学術集会抄録集   2017年3月

【基礎研究を予防心臓病学の未来に活かす】 心不全における骨格筋萎縮予防

沖田 孝一, 高田 真吾, 横田 卓, 絹川 真太郎

心臓リハビリテーション   2017年1月

循環器領域における骨格筋の役割 心不全における骨格筋異常をターゲットとした治療法の開発

絹川 真太郎, 福島 新, 高田 真吾, 松本 純一

血管   2017年1月

Brain-derived Neurotrophic Factor Plays an Important Role of Exercise Capacity and Mitochondrial Function in the Skeletal Muscle in Mice With Post-infarct Heart Failure

Takayuki Nakajima, Shintaro Kinugawa, Junichi Matsumoto, Shingo Takada, Takaaki Furihata, Masaya Tsuda, Takashi Katayama, Hideo Nanbu, Ryosuke Shirakawa, Satoshi Maekawa, Naoya Kakutani, Wataru Mizushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2016年11月

The Activation of Glucagon-Like Peptide-1 Improves the Mitochondrial Abnormalities in Skeletal Muscle and Exercise Intolerance in Heart Failure Mice

Takashi Katayama, Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takayuki Nakajima, Masaya Tsuda, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2016年11月

Mitochondrial Protein Acetylation in Skeletal Muscle Was Associated With Exercise Intolerance in Heart Failure After Myocardial Infarction in Mice

Masaya Tsuda, Shintaro Kinugawa, Shingo Takada, Arata Fukushima, Takashi Yokota, Wataru Mizushima, Takaaki Furihata, Junichi Matsumoto, Takashi Katayama, Takayuki Nakajima, Satoshi Maekawa, Hideo Nambu, Ryosuke Shirakawa, Naoya Kakutani, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2016年11月

A Multi-Center Observational Study of Dilated Phase of Hypertrophic Cardiomyopathy

Shouji Matsushima, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

心不全における多臓器不全 心不全における骨格筋異常 マイオカインの役割

絹川 真太郎, 松本 純一, 高田 真吾

日本心臓病学会学術集会抄録   2016年9月

The Activation of Glucagon-Like Peptide-1 Improves the Mitochondrial Abnormalities in Skeletal Muscle and Exercise Intolerance in Heart Failure Mice

Takashi Katayama, Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, Junichi Matsumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Plasma Acetyl-lysine is a Novel Marker for Exercise Capacity in Patients With Heart Failure

Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Takashi Yokota, Takaald Furihata, Junichi Matsumoto, Takashi Katayama, Takayuki Nakajima, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Pioglitazone Improves Aerobic Capacity and Skeletal Muscle Energy Metabolism in Patients with Metabolic Syndrome

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Shingo Takada, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Nutritional Assessment in Patients with Heart Failure and Exercise Intolerance -Comparative Analysis of GNRI, MNA, and CONUT-

Takeshi Sota, Yoshiharu Kinugasa, Hiroko Kamitani, Natsuko Nakayama, Miyuki Makaya, Shintaro Kinugawa, Takahiro Naruse, Masahiko Kato, Hiroshi Hagino, Kazuhiro Yamamoto

JOURNAL OF CARDIAC FAILURE   2016年9月

Nifedipine Negatively Regulates Nox4 and Inhibits HDAC4 Oxidation in Phenylephrine-Induced Cardiac Hypertrophy

Shouji Matsushima, Junichi Matsumoto, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

JOURNAL OF CARDIAC FAILURE   2016年9月

NADPH Oxidase 4 is a Major Source of Mitochondrial Reactive Oxygen Species in the Heart

Shouji Matsushima, Shintaro Kinugawa, Junichi Sadoshima, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

HeartMate IIから離脱し得た拡張型心筋症の一症例

表和徳, 榊原守, 高橋雅之, 浅川直也, 野口圭士, 徳田裕輔, 神谷究, 松島将士, 絹川真太郎, 大岡智学, 松居喜郎, 筒井裕之

日本循環器学会北海道地方会(Web)   2016年9月

Development of Novel Therapeutic Strategy for Heart Failure via Activating Invariant Natural Killer T Cells

Naoki Ishimori, Akimichi Saito, Shintaro Kinugawa, Wataru Mizushima, Ryousuke Shirakawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Comparative Analysis of Ability to Assess Nutritional Status between CONUT and GNRI in Patients with Heart Failure

Hiroko Kamitani, Yoshiharu Kinugasa, Takeshi Sota, Natsuko Nakayama, Miyuki Makaya, Shintaro Kinugawa, Takahiro Naruse, Masahiko Kato, Hiroshi Hagino, Kazuhiro Yamamoto

JOURNAL OF CARDIAC FAILURE   2016年9月

Cardiac Hypertrophy in Neonates With Congenital Heart Disease Delays Maturational Alterations in Cardiac Energy Metabolism by Modifying Myocardial Acetylation Control

Arata Fukushima, Alda Huqi, Liyan Zhang, Victoria H. Lam, Tariq Altamimi, Shintaro Kinugawa, Hiroyuki Tsutsui, Ivan M. Rebeyka, Paul F. Kantor, Gary D. Lopaschuk

JOURNAL OF CARDIAC FAILURE   2016年9月

Brain-Derived Neurotrophic Factor Regulates Exercise Capacity and Mitochondria' Function in the Skeletal Muscle in Mice with Post-Infarct Heart Failure

Junichi Matsumoto, Shingo Takada, Shintaro Kinugawa, Takaaki Furihata, Masaya Tsuda, Takayuki Nakajima, Takashi Katayama, Wataru Mizushima, Takashi Yokota, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Association of Helicobacter Pylori with Chronic Heart Failure

Shouji Matsushima, Masaya Tsuda, Junichi Matsumoto, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2016年9月

Analysis of Expired Gas During the Hemodialysis in Patients With Cardiovascular Disease

Motoki Nakao, Masashige Takahashi, Kou Motoi, Hikaru Hagiwara, Yoshikuni Obata, Hidetsugu Sakai, Shintaro Kinugawa, Koichi Okita

JOURNAL OF CARDIAC FAILURE   2016年9月

Acetylation Control Contributes to Maturational Alterations in Cardiac Energy Metabolism in the Newborn Heart

Arata Fukushima, Osama A. Alrob, Liyan Zhang, Cory S. Wage, Tariq Altamimi, Shintaro Kinugawa, Hiroyuki Tsutsui, Ivan M. Rebeyka, Paul F. Kantor, Gary D. Lopaschuk

JOURNAL OF CARDIAC FAILURE   2016年9月

Alpha-galactosylceramide-pulsed human dendritic cells can ameliorate post-infarct cardiac remodeling and failure in mice

A. Saito, N. Ishimori, M. Nishikawa, Y. Masaki, S. Kinugawa, H. Tsutsui

EUROPEAN HEART JOURNAL   2016年8月

Brain-derived neurotrophic factor improves exercise capacity and mitochondrial function in the skeletal muscle in mice with post-infarct heart failure

J. Matsumoto, S. Takada, S. Kinugawa, W. Mizushima, T. Furihata, M. Tsuda, T. Nakajima, T. Katayama, T. Yokota, K. Okita, H. Tsutsui

EUROPEAN HEART JOURNAL   2016年8月

維持期慢性心不全患者の良好な栄養状態には食事パターンが影響する 栄養疫学研究から

池田 陽子, 絹川 真太郎, 眞茅 みゆき

日本静脈経腸栄養学会雑誌   2016年1月

心不全モデルマウスにおける骨格筋ミトコンドリア機能低下に対する脳由来神経栄養因子の役割解明

高田 真吾, 絹川 真太郎, 横田 卓, 松島 将士, 沖田 孝一, 筒井 裕之

体力科学   2015年12月

酸化ストレスの抑制はアンジオテンシンII誘発性の骨格筋萎縮を改善する

門口 智泰, 絹川 真太郎, 高田 真吾, 田中 寿人, 沖田 孝一, 筒井 裕之

体力科学   2015年12月

心臓リハビリテーション すべてわかるWhy～Howから最先端 サルコペニア、フレイル、マイオカインとは?

高田 真吾, 絹川 真太郎, 沖田 孝一, 筒井 裕之

日本冠疾患学会雑誌   2015年11月

Brain-Derived Neurotrophic Factor Could Regulate Mitochondrial Function in the Skeletal Muscle Through Ampk-Pgc1 alpha Signaling in Heart Failure Mice

Takayuki Nakajima, Shintaro Kinugawa, Shingo Takada, Junichi Matsumoto, Wataru Misushima, Takaaki Furihata, Masaya Tsuda, Takashi Yokota, Shouji Matsushima, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2015年10月

血流制限を併用したレジスタンス運動が血管機能へ影響

沖田 孝一, 高田 真吾, 門口 智泰, 森田 憲輝, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

北翔大学北方圏生涯スポーツ研究センター年報   2015年10月

Metabolomic Analysis Reveals New Insights Towards Understanding Skeletal Muscle Mass and Exercise Capacity in Patients with Heart Failure

Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Takashi Yokota, Shoji Matsushima, Takaaki Furihata, Junichi Matsumoto, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2015年10月

ナチュラルキラーT細胞活性化による新たな心不全治療法の開発

筒井裕之, 絹川真太郎, 石森直樹, 佐藤典宏, 本橋新一郎

先進医薬研究振興財団 2014年度 研究成果報告集   2015年3月

精神及び身体機能高度低下例における複合的音楽療法の可能性

沖田 孝一, 森田 憲輝, 高田 真吾, 舛谷 夕貴, 絹川 真太郎, 佐々木 浩子, 澤田 悦子

心臓リハビリテーション   2015年3月

心不全における水管理

絹川 真太郎, 筒井 裕之

循環器内科   2015年1月

アンジオテンシンII受容体阻害薬はストレプトゾトシン誘発性糖尿病マウスにおける運動能力低下と骨格筋代謝障害を改善する

菅 唯志, 絹川 真太郎, 高田 真吾, 門口 智泰, 筒井 裕之

体力科学   2014年12月

レニン・アンジオテンシン系の活性化は骨格筋異常を介して運動能力低下を引き起こす

門口 智泰, 絹川 真太郎, 高田 真吾, 菅 唯志, 田中 寿人, 沖田 孝一, 筒井 裕之

体力科学   2014年12月

心筋梗塞後心不全における骨格筋ミトコンドリア機能および運動能力に対するDPP-4阻害薬の効果

高田 真吾, 絹川 真太郎, 正木 芳宏, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

体力科学   2014年12月

AST-120 Ameliorates Lowered Exercise Capacity and Mitochondrial Dysfunction of the Skeletal Muscle in Mice with Chronic Kidney Disease via Reducing Oxidative Stress

Mikito Nishikawa, Naoki Ishimori, Shingo Takada, Akimichi Saito, Tomoyasu Kadoguchi, Takaaki Furihata, Arata Fukushima, Shouji Matsushima, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Influence of Nutritional Status on Depressive Symptoms and Quality of Life in Patients With Heart Failure

Miyuki Tsuchihashi-Makaya, Arata Fukushima, Shintaro Kinugawa, Yoshiharu Kinugasa, Taisuke Ono, Hisashi Matsuo, Akiko Okada, Masahiko Kato, Kazuhiro Yamamoto, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Impact of Health Literacy on Long-Term Outcomes in Patients with Heart Failure

Miyuki Tsuchihashi-Makaya, Shiho Matsuoka, Takahiro Kayane, Masako Koizumi, Michiyo Yamada, Akiko Okada, Miyuki Yazawa, Shintaro Kinugawa

CIRCULATION   2014年11月

Fyn is a Sensor and Regulator of Nox4-derived ROS in the Heart

Shoji Matsushima, Junya Kuroda, Peiyong Zhai, Tong Liu, Hong Li, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

CIRCULATION   2014年11月

Disruption of Outer Mitochondrial Membrane Protein, MitoNEET, Increases Mitochondrial Iron Content in the Heart

Takaaki Furihata, Shintaro Kinugawa, Shouji Matsushima, Shingo Takada, Arata Fukushima, Wataru Mizushima, Tomoyasu Kadoguchi, Yoshihiro Masaki, Takashi Yokota, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Circulating Invariant Natural Killer T Cells are Decreased in Patients With Chronic Heart Failure

Akimichi Saito, Naoki Ishimori, Mikito Nishikawa, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Changes of Metabolomic Profiling Are Associated With Reduced Exercise Capacity in Patients With Heart Failure

Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Shoji Matsushima, Takaaki Furihata, Shingo Takada, Tomoyasu Kadoguchi, Masato Kudo, Junichi Matsumoto, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Brain-Derived Neurotrophic Factor Maintains Exercise Capacity and Mitochondrial Function in the Skeletal Muscle Through Ampk-Pgc1 alpha Signaling

Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Wataru Mizushima, Arata Fukushima, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Tadashi Suga, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Angiotensin II Directly Induces Mitochondrial Dysfunction and Atrophy in the Skeletal Muscle

Tomoyasu Kadoguchi, Shintaro Kinugawa, Arata Fukushima, Takaaki Furihata, Tadashi Suga, Shingo Takada, Wataru Mizushima, Masato Kudo, Junichi Matsumoto, Masaya Tsuda, Mikito Nishikawa, Takashi Yokota, Shoji Matsushima, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2014年11月

Angiotensin II Could Directly Induced Mitochondrial Dysfunction and Atrophy in the Skeletal Muscle

Tomoyasu Kadoguchi, Shintaro Kinugawa, Arata Fukushima, Takaaki Furihata, Shingo Takada, Takashi Yokota, Shoji Matsushima, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2014年10月

Nifedipine Attenuates Cardiac Hypertrophy by Inhibiting Nox4-induced Oxidation of HDAC4

Junichi Matsumoto, Shouji Matsushima, Shintaro Kinugawa, Hiroyuki Tsutsui, Junichi Sadoshima

JOURNAL OF CARDIAC FAILURE   2014年10月

Circulating Invariant Natural Killer T Cells are Decreased in Patients With Chronic Heart Failure

Akimichi Saito, Naoki Ishimori, Mikito Nishikawa, Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2014年10月

Changes of Metabolomic Profiling are Associated with Reduced Exercise Capacity in Patients with Heart Failure

Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shoji Matsushima, Takaaki Furihata, Shingo Takada, Masato Kudo, Junichi Matsumoto, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2014年10月

Sesamin improves lowered exercise capacity and mitochondrial dysfunction in the skeletal muscle from high fat diet-induced diabetic mice

S. Takada, S. Kinugawa, D. Takemoto, T. Kadoguchi, T. Yokota, S. Matsushima, A. Fukushima, Y. Masaki, T. Furihata, T. Suga, W. Mizushima, Y. Ono, H. Shibata, K. Okita, H. Tsutsui

DIABETOLOGIA   2014年9月

北海道における心臓移植報告

大岡 智学, 新宮 康栄, 若狭 哲, 松居 喜郎, 榊原 守, 絹川 真太郎, 筒井 裕之, 小林 真梨子, 久保田 卓, 杉木 宏司

日本移植学会総会プログラム抄録集   2014年8月

Dipeptidyl Peptidase-4 Inhibitor Improved Exercise Capacity in Association with Switching to Oxidative Skeletal Muscle Fiber Type in Mice with Post-infarct Heart Failure

Yoshihiro Masaki, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Takaaki Furihata, Ryoichi Katsuyama, Tadashi Suga, Masashige Takahashi, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui

DIABETES   2014年6月

北海道大学における植込型補助人工心臓治療及び心臓移植実施体制の現状

大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 絹川 真太郎, 榊原 守, 筒井 裕之, 小林 真梨子, 浅野 恵子, 寒河江 磨, 法邑 まなみ, 矢萩 亮児, 加藤 伸彦

移植   2014年5月

第18回欧州スポーツ医学会2013年6月26-29日バルセロナ、スペインにおける発表 レジスタンス運動における血流制限のタイミングの影響(18th Annual Congress of European College of Sports Science, 26-29 June 2013, Bacelona, Spain: Effect of Blood Flow Restriction Timing in Enhancing Intramuscular Metabolic Stress During R

沖田 孝一, 高田 真吾, 菅 唯志, 門口 智泰, 森田 憲輝, 谷浦 有史, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

北翔大学北方圏生涯スポーツ研究センター年報   2014年4月

心-骨格筋連関 (特集 2025年を見すえた心不全診療ロードマップ : 突破口はどこにあるのか) -- (臓器連関をどう理解するか)

絹川 真太郎, 沖田 孝一

内科   2014年3月

一酸化窒素は運動誘発性の運動能力と骨格筋ミトコンドリア増加を調節する

門口 智泰, 絹川 真太郎, 菅 唯志, 小野 太祐, 横田 卓, 高田 真吾, モハマド・アリ・ソビリン, 高橋 将成, 福島 新, 本間 恒章, 正木 芳宏, 平林 鑑, 沖田 孝一, 筒井 裕之

心臓リハビリテーション   2014年2月

アンジオテンシンII由来の酸化ストレスは骨格筋異常を引き起こす

門口 智泰, 絹川 真太郎, 菅 唯志, 高田 真吾, 沖田 孝一, 筒井 裕之

体力科学   2013年12月

酪酸は運動能力および骨格筋ミトコンドリア機能を増加する

菅 唯志, 絹川 真太郎, 高田 真吾, 門口 智泰, 伊坂 忠夫, 沖田 孝一, 筒井 裕之

体力科学   2013年12月

慢性心不全患者における脳由来神経栄養因子の低下は運動耐容能の低下に関連する

高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

体力科学   2013年12月

Disruption of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

Ryoichi Katsuyama, Shintaro Kinugawa, Tsuneaki Homma, Takaaki Furihata, Arata Fukushima, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Shouji Matsushima, Hiroyuki Tsutsui

CIRCULATION   2013年11月

Serum Myostatin Levels Are Independent Determinant of Skeletal Muscle Wasting in Patients With Heart Failure

Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Shouji Matsushima, Takashi Yokota, Hiroyuki Tsutsui

CIRCULATION   2013年11月

Clinical Characteristics, Prognosis, and Management of Hospitalized Patients with Heart Failure in Japan

Shintaro Kinugawa

JOURNAL OF CARDIAC FAILURE   2013年10月

Skeletal Muscle Abnormalities and Exercise Training in Heart Failure with Preserved Ejection Fraction

Shintaro Kinugawa

JOURNAL OF CARDIAC FAILURE   2013年10月

Fyn Plays a Critical Role in Regulating Apoptosis of Cardiac Myocyte in Failing Heart through Tyrosine-phosphorylation of Nox4

Shouji Matsushima, Shintaro Kinugawa, Junichi Sadoshima, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2013年10月

Decreased Serum BDNF Levels are Correlated with Lower Exercise capacity in Patients with Heart Failure

Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Shingo Takada, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2013年10月

β遮断薬 (特集 循環器薬 : 使い方プラクティス) -- (疾患別循環器薬の使い方)

絹川 真太郎, 筒井 裕之

内科   2013年9月

右膝窩巨大嚢状静脈瘤が血栓塞栓源となり肺動脈血栓塞栓症を発症した一症例

天満太郎, 木村銀河, 福島新, 絹川真太郎, 納谷昌直, 筒井裕之, 久保田卓, 松居喜郎, 早川峰司

日本心臓病学会誌   2013年9月

心筋梗塞後の心筋リモデリングおよび心不全におけるNKT細胞の役割 (AYUMI 生活習慣病とNKT細胞 : 病態モジュレーターの面から)

絹川 真太郎, 筒井 裕之

医学のあゆみ   2013年7月

心不全における利尿薬耐性の病態と対策 (特集 治療抵抗性心不全における体液コントロール)

絹川 真太郎, 筒井 裕之

2013年4月

TrkBアゴニストは運動トレーニングによる運動能力向上を模擬する

高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 森田 憲輝, 沖田 孝一, 筒井 裕之

体力科学   2012年12月

高齢者における血中脳性神経栄養因子の低下

谷浦 有史, 沖田 孝一, 高田 真吾, 菅 唯志, 門口 智泰, 絹川 真太郎, 筒井 裕之

体力科学   2012年12月

クルクミンはタンパク分解を抑制して糖尿病誘発性骨格筋萎縮を軽減する

門口 智泰, 絹川 真太郎, 菅 唯志, 高田 真吾, 小野 太祐, 沖田 孝一, 筒井 裕之

体力科学   2012年12月

BDNF-TrkB Pathway Plays an Important Role in the Effects of Exercise Training on Exercise Capacity and Skeletal Muscle Function in Mice

Shingo Takada, Shintaro Kinugawa, Tadashi Suga, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takaaki Furihata, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2012年11月

The Activation of Natural Killer T Cells Ameliorates Post-Infarct Cardiac Remodeling and Failure in Mice

Mochamad Ali Sobirin, Shintaro Kinugawa, Masashige Takahashi, Arata Fukushima, Masaru Taniguchi, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

CARDIOVASCULAR THERAPEUTICS   2012年11月

Impact of Sarcomere Gene Mutations on Clinical Outcome of Left Ventricular Hypertrophy: Evidence from Comparison with Hypertension-related Hypertrophy

Takashi Fujita, Noboru Fujino, Tetsuo Konno, Masanori Asakura, Masafumi Kitakaze, Toru Kubo, Yoshinori Doi, Shintaro Kinugawa, Hiroyuki Tsutsui, Issei Komuro, Ryuichiro Anan, Chuwa Tei, Masakazu Yamagishi

CIRCULATION   2012年11月

Endothelial Nitric Oxide (NO) Synthase-Derived NO Plays an Essential Role in the Beneficial Effects of Exercise Training via Activating Skeletal Muscle Mitochondrial Biogenesis

Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Masaski Yoshihiro, Okita Koichi, Tsutsui Hiroyuki

CIRCULATION   2012年11月

Dipeptidyl Peptidase-4 Inhibitor Can Ameliorate the Decreased Exercise Capacity in Heart Failure After Myocardial Infraction in Mice With the Skeletal Muscle Switch to Oxidative Fiber Type

Yoshihiro Masaki, Shintaro Kinugawa, Arata Fukushima, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Takaaki Furihata, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2012年11月

Skeletal Muscle Abnormalities in Heart Failure

Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2012年10月

糖尿病と心不全 (特集 糖尿病性心血管合併症 : update)

筒井 裕之, 絹川 真太郎

循環器内科   2012年10月

The Activation of Invariant Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

Tsuneaki Homma, Shintaro Kinugawa, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takaaki Furihata, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2012年10月

The Activation of (Pro)renin Receptor Plays an Important Role on the Development of Insulin Resistance in Experimental Post-infarct Heart Failure

Arata Fukushima, Shintaro Kinugawa, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2012年10月

Effect of Exercise with Blood Flow Restriction Depends on Total Work Regardless of Mechanical Intensity

Shingo Takada, Koichi Okita, Masashi Omokawa, Tadashi Suga, Noriteru Morita, Masahiro Horiuchi, Tomoyasu Kadoguchi, Takashi Sato, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Shintaro Kinugawa, Hiroyuki Tsutsui

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2012年5月

体外式補助人工心臓装着患者に対する心臓リハビリテーションの経験

阿部隆宏, 堀享一, 横田卓, 絹川真太郎, 後藤大祐, 大岡智学, 久保田卓, 松居喜郎, 筒井裕之, 生駒一憲

北海道リハビリテーション学会雑誌   2012年5月

梗塞後心不全において酸化ストレスは骨格筋のインスリンシグナルを障害し, インスリン抵抗性を誘導する

太田 幸博, 絹川 真太郎, 松島 将士, 小野 太祐, アリ ソビリン, 井上 直樹, 横田 卓, 平林 鑑, 筒井 裕之

北海道醫學雜誌 = Acta medica Hokkaidonensia   2012年4月

ピオグリタゾンはインスリン抵抗性患者の骨格筋エネルギー代謝を改善し有酸素運動能を増加させる

高橋 将成, 絹川 真太郎, 横田 卓, 平林 鑑, 高田 真吾, 菅 唯志, 福島 新, 本間 恒章, 正木 芳宏, 門口 智泰, 佐藤 貴志, 沖田 孝一, 筒井 裕之

心臓リハビリテーション   2012年2月

酸化ストレスと心不全患者における骨格筋異常

高田 真吾, 絹川 真太郎, 平林 鑑, 横田 卓, 菅 唯志, 高橋 将成, 福島 新, 本間 恒章, 正木 芳宏, 門口 智泰, 佐藤 貴志, 森田 憲輝, 堀内 雅弘, 沖田 孝一, 筒井 裕之

心臓リハビリテーション   2012年2月

診断へのアプローチ(病歴聴取と身体診察)

絹川 真太郎, 筒井 裕之

日本内科学会雑誌   2012年2月

血流制限を併用した筋力トレーニングの効果 女性における至適方法の検討へ

沖田 孝一, 絹川 真太郎, 横田 卓, 森田 憲輝, 佐々木 浩子

女性健康科学研究会受賞研究報告集   2012年1月

アンジオテンシンII受容体阻害薬は高脂肪食誘発糖尿病マウスにおける運動能力低下を改善する

高田 真吾, 絹川 真太郎, 菅 唯志, 門口 智泰, 沖田 孝一, 筒井 裕之

体力科学   2011年12月

血液依存性血管拡張反応 上下肢および男女における検討

谷浦 有史, 沖田 孝一, 佐藤 貴志, 菅 唯志, 高田 真吾, 門口 智泰, 森田 憲輝, 高橋 将成, 福島 新, 絹川 真太郎, 堀内 雅弘, 筒井 裕之

体力科学   2011年12月

血流依存性血管拡張能と筋力における関連性の検討

門口 智泰, 沖田 孝一, 菅 唯志, 高田 真吾, 佐藤 貴志, 面川 雅司, 森田 憲輝, 堀内 雅弘, 絹川 真太郎, 筒井 裕之

体力科学   2011年12月

レジスタンス運動が動脈機能へ与える影響 血流制限を併用した検討

佐藤 貴志, 沖田 孝一, 菅 唯志, 高田 真吾, 門口 智泰, 森田 憲輝, 高橋 将成, 福島 新, 絹川 真太郎, 鎌倉 一, 堀内 雅弘, 筒井 裕之

体力科学   2011年12月

Angiotensin II Receptor Blocker Improves Exercise Capacity and Mitochondrial Function of Skeletal Muscle via Inhibiting Oxidative Stress in High Fat Diet-Induced Diabetic Mice

Shingo Takada, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Sobirin A. Mochamad, Taisuke Ono, Yoshihiro Masaki, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2011年11月

Nitric Oxide is Involved the Beneficial Effects of Exercise Training via Activating Skeletal Muscle Mitochondrial Biogenesis in Mice

Tadashi Suga, Shintaro Kinugawa, Taisuke Ono, Takashi Yokota, Shingo Takada, Mochamad A. Sobirin, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Tomoyasu Kadoguchi, Yoshihiro Masaki, Kagami Hirabayashi, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2011年11月

Enhanced Oxidative Stress is Correlated With Skeletal Muscle Abnormalities in Patients With Metabolic Syndrome

Shintaro Kinugawa, Takashi Yokota, Kagami Hirabayashi, Tadashi Suga, Masashige Takahashi, Shingo Takada, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2011年11月

Direct Renin Inhibitor Ameliorates Insulin Resistance by Improving Insulin Signaling in the Skeletal Muscle in Experimental Post-Infarct Heart Failure

Arata Fukushima, Shintaro Kinugawa, Takashi Yokota, Sobrin A. Mochamad, Masashige Takahashi, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Kouichi Okita, Hiroyuki Tsutsui

CIRCULATION   2011年11月

The Activation of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

Tsuneaki Homma, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Taisuke Ono, Mochamad A. Sobirin, Hiroyuki Tsutsui

CIRCULATION   2011年11月

The Enhanced Oxidative Stress is Associated with Skeletal Muscle Abnormalities in Patients with Heart Failure

Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Masashige Takahashi, Shingo Takada, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2011年11月

The Disruption of Natural Killer T Cell Receptor Exacerbates Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Mochamad A. Sobirin, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Yoshihiro Masaki, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION   2011年11月

The Disruption of Natural Killer T Cell Exacerbates Cardiac Hypertrophy and Heart Failure Due to Pressure Overload in Mice

Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Mochamad A. Sobirin, Tadashi Suga, Shingo Takada, Taisuke Ono, Yoshihiro Masaki, Tomoyasu Kadoguchi, Takashi Yokota, Shintaro Kinugawa, Hiroyuki Tsutsui

CIRCULATION   2011年11月

Direct Renin Inhibitor (Aliskiren) Improves Insulin Resistance and Impaired Insulin Signal in Post-Infarct Heart Failure

Arata Fukushima, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Tsuneaki Homma, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2011年9月

The Disruption of Natural Killer T cell Exacerbates Cardiac Hypertrophy and Heart Failure Due to Pressure Overload in Mice

Shintaro Kinugawa, Masashige Takahashi, Shingo Takada, Arata Fukushima, Tomoyasu Kadoguchi, Tadashi Suga, Mochamad Ali Sobirin, Taisuke Ono, Tsuneaki Homma, Hiroyuki Tsutsu

JOURNAL OF CARDIAC FAILURE   2011年9月

The Activation of Natural Killer T Cells Ameliorates Myocardial Ischemia Reperfusion Injury in Mice

Tsuneaki Homma, Shintaro Kinugawa, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tadashi Suga, Shingo Takada, Yoshihiro Masaki, Tomoyasu Kadoguchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2011年9月

The activation of natural killer T cells ameliorates post-infarct heart failure in mice

M. A. Sobirin, S. Kinugawa, M. Takahashi, T. Ono, A. Fukushima, T. Yokota, T. Homma, N. Ishimori, K. Iwabuchi, H. Tsutsui

EUROPEAN HEART JOURNAL   2011年8月

腎障害合併心不全の病態と治療 (特集 利尿薬と心不全)

絹川 真太郎, 筒井 裕之

2011年7月

Discharge Use of Spironolactone was Associated with Lower Long-term Mortality in Patients Hospitalized with Systolic Heart Failure

Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Miyuki Tsuchihashi-Makaya, Hiroyuki Tsutsui

CIRCULATION   2010年11月

慢性心不全の患者背景,治療,長期予後における性差

眞茅みゆき, 絹川真太郎, 濱口早苗, 後藤大祐, 古本智夫, 横式尚司, 筒井裕之

日本高血圧学会総会プログラム・抄録集   2010年10月

Pioglitazone increases the aerobic capacity with improved skeletal muscle energetics in patients with insulin resistance

T. Yokota, S. Kinugawa, K. Hirabayashi, T. Suga, S. Takada, M. Takahashi, S. A. Mochamad, T. Ono, N. Morita, K. Okita, H. Tsutsui

DIABETOLOGIA   2010年9月

The Effect on Intramuscular Metabolic Stress During Low-Intensity Resistance Exercise With Blood Flow Restriction in Patients With Heart Failure

Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Tadashi Suga, Arata Fukushima, Tomoyasu Kadoguchi, Kagami Hirabayashi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2010年9月

The Disruption of Natural Killer T Cell Receptor Exacerbates Post-Infarct Heart Failure in Mice

Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2010年9月

The Activation of Natural Killer T Cells Ameliorates Post-Infarct Heart Failure in Mice

Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2010年8月

慢性心不全に対する運動療法の継続に及ぼす患者背景因子の検討

後藤大祐, 堀享一, 絹川真太郎, 横田卓, 小島尚子, 筒井裕之

心臓リハビリテーション   2010年6月

血流制限を併用した短期間の低強度筋力トレーニングが筋量・筋力および動脈硬化指標に与える影響

門口智泰, 沖田孝一, 菅唯志, 高田真吾, 面川雅司, 佐藤貴志, 今泉貴, 森田憲輝, 高橋将成, 横田卓, 平林鑑, 絹川真太郎, 筒井裕之

心臓リハビリテーション   2010年6月

Difference In Metabolic Stress During Resistance Exercise With Blood Flow Restriction Between Sprinters And Endurance Runners

Tomoyasu Kadoguchi, Koichi Okita, Tadashi Suga, Shingo Takada, Masashi Omokawa, Noriteru Morita, Masahiro Horiuchi, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Shintaro Kinugawa, Hiroyuki Tsutsui

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2010年5月

High-metabolic Stress During Resistance Exercise Might Provide Muscle Hypertrophy And Strength Increase Even With Low-mechanical Stimulus

Shingo Takada, Koichi Okita, Tadashi Suga, Masashi Omokawa, Tomoyasu Kadoguchi, Noriteru Morita, Masahiro Horiuchi, Masashige Takahashi, Takashi Yokota, Kagami Hirabayashi, Shintaro Kinugawa, Hiroyuki Tsutsui

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   2010年5月

Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) (vol 73, pg 1893, 2009)

Miyuki Tsuchihashi-Makaya, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Hisashi Yokoshiki, Norihiro Kato, Akira Takeshita, Hiroyuki Tsutsui

CIRCULATION JOURNAL   2009年12月

Pioglitazone Improves Aerobic Capacity and Skeletal Muscle High-Energy Phosphate Metabolism in Patients With Metabolic Syndrome

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Noriteru Morita, Masahige Takahashi, Shingo Takada, Masashi Omokawa, Shouji Matsushima, Mochamad A. Sobirin, Taisuke Ono, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2009年11月

The Increase in Intramyocellular Lipid in Leg Skeletal Muscle is Associated With Lowered Aerobic Exercise Capacity in Patients With Heart Failure

Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Noriteru Morita, Taisuke Ono, Mochamad A. Sobirin, Masashige Takahashi, Koichi Okita, Hiroyuki Tsutsui

CIRCULATION   2009年11月

Role of Chronic Inflammation in Left Ventricular Remodeling and Failure After Myocardial Infarction

Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2009年9月

The Increase in Intramyocellular Lipid in Leg Skeletal Muscle is Associated With Lowered Aerobic Exercise Capacity in Heart Failure Patients

Kagami Hirabayashi, Shintaro Kinugawa, Takashi Yokota, Tadashi Suga, Noriteru Morita, Taisuke Ono, Mochamad Ali Sobirin, Masashige Takahashi, Koichi Okita, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2009年9月

The Activation of Natural Killer T Cells Ameliorates Post-Infarct Heart Failure in Mice

Mochamad Ali Sobirin, Shintaro Kinugawa, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2009年9月

重症心機能障害を併発した強皮症患者の治療に難渋した一例

有賀伸, 榊原守, 野澤篤史, 穴田真奈美, 納谷昌直, 絹川真太郎, 古本智夫, 筒井裕之

2009年4月

新規開発臓器保存液を用いた心冷保存限界延長の試み

若山 顕治, 深井 原, 山下 健一郎, 後藤 了一, 植木 伸也, 福森 大介, 柴崎 晋, 大浦 哲, 廣方 玄太郎, 芳賀 早苗, 谷口 雅彦, 鈴木 友己, 嶋村 剛, 松下 道明, 古川 博之, 尾崎 倫孝, 藤堂 省, 小野 太祐, 絹川 真太郎, 筒井 裕之, 菅原 満

日本外科学会雑誌   2009年2月

画像診断と病理 強皮症に伴う心筋症

藤間憲幸, 大山徳子, 榊原守, 納谷昌直, 絹川真太郎, 久保田佳奈子, 松野吉宏

画像診断   2008年11月

30) 修正大血管転位症術後のAFLに対して,アブレーション治療が有効だった1例(第99回日本循環器学会北海道地方会)

渡邉 昌也, 安藤 康博, 絹川 真太郎, 川嶋 望, 三山 博史, 下川 淳一, 横式 尚司, 山田 聡, 筒井 裕之, 西浦 猛, 大場 淳一, 松居 喜郎

2008年10月

Type 2 Diabetes Is Associated with the Exacerbation of Heart Failure via Increasing Myocardial NAD(P)H Oxidase-Derived Superoxide Production

Shintaro Kinugawa, Shouji Matsushima, Takashi Yokota, Yukihiro Ohta, Naoki Inoue, Hiroyuki Tsutsui

CIRCULATION   2008年10月

Impaired Skeletal Muscle Energy Metabolism Limits Aerobic Exercise Capacity in Patients with Metabolic Syndrome

Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Naoki Inoue, Yukihiro Ohta, Shouji Matsushima, Sanae Hamaguchi, Mochamad A. Sobirin, Taisuke Ono, Noriteru Morita, Kouichi Okita, Hiroyuki Tsutsui

CIRCULATION   2008年10月

Beta-blocker use at discharge in patients hospitalized for heart failure is associated with improved survival: An analysis from JCARE-CARD

Miyuki Makaya, Hiroyuki Tsutsui, Sanae Hamaguchi, Shintaro Kinugawa, Takashi Yokota, Daisuke Goto, Akira Takeshita

JOURNAL OF CARDIAC FAILURE   2008年9月

Oxidative stress through the activation of renin-angiotensin system in skeletal muscle causes insulin resistance in mice with heart failure

Shintaro Kinugawa, Yukihiro Ohta, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2008年9月

Novel treatment strategies against left ventricular remodeling and failure after infarction by attenuating mitochondrial oxidative stress

Shintaro Kinugawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2008年9月

7) 冠動脈左室憩室瘻と心室中隔欠損を合併した1例(第98回日本循環器学会北海道地方会)

川崎 いくみ, 渡邉 昌也, 安藤 康博, 岡田 昌子, 絹川 真太郎, 川嶋 望, 山田 聡, 筒井 裕之

2008年4月

NOS dependent gene regulation in cardiac tissues of conscious type I diabetic dogs

Caroline Ojaimi, Shintaro Kinugawa, Thomas H. Hintze

FASEB JOURNAL   2008年4月

血流制限下低強度レジスタンス運動中の筋内エネルギー代謝

菅 唯志, 沖田 孝一, 高田 真吾, 高橋 智宏, 面川 雅司, 森田 憲輝, 堀内 雅弘, 平林 鑑, 横田 卓, 絹川 真太郎, 筒井 裕之

心臓リハビリテーション   2008年1月

34)左室流出路狭窄を合併した重症大動脈弁狭窄症に弁置換術と同時に心筋切除術を施行した一例(第97回日本循環器学会北海道地方会)

平林 鑑, 笹井 春江, 相馬 孝光, 絹川 真太郎, 古本 智夫, 山田 聡, 横式 尚司, 小野塚 久夫, 筒井 裕之, 松居 喜郎

2007年10月

左心補助装置から離脱しえた巨細胞性劇症型心筋炎の1例

平林 鑑, 山田 聡, 石見 かおり, 絹川 真太郎, 蒔田 直昌, 岡本 洋, 筒井 裕之, 杉木 宏司, 村下 十志文, 中川 雄太

日本内科学会雑誌   2007年2月

Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress

Nobuhiro Suematsu, Caroline Ojaimi, Shintaro Kinugawa, Xiaobin Xu, Fabio Recchia, Thomas Hintze

CIRCULATION   2006年10月

National registry of patients with chronic heart failure in Japan - JCARE study

Hiroyuki Tsutsui, Miyuki Tsuchihashi, Shintaro Kinugawa, Daisuke Goto, Akira Takeshita

JOURNAL OF CARDIAC FAILURE   2006年10月

NAD(P)H oxidase-derived oxidative stress is involved in the exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction

Shouji Matsushima, Shintaro Kinugawa, Naoki Inoue, Yukihiro Ohta, Takashi Yokota, Kenji Sunagawa, Hiroyuki Tsutsui

JOURNAL OF CARDIAC FAILURE   2006年10月

心不全における酸化ストレスの役割 (第1土曜特集 酸化ストレスと心血管疾患--分子機構の解明から治療への応用まで) -- (病態形成における酸化ストレスの役割)

絹川 真太郎, 筒井 裕之

医学のあゆみ   2006年7月

心不全における骨格筋異常一酸化窒素と酸化ストレスの役割

筒井 裕之, 絹川 真太郎, 沖田 孝一

循環制御 = CIRCULATION CONTROL   2006年6月

Chronic hyperhomocysteinemia regulates cardiac myocyte gene expression creating a cardiac metabolic disease

C Ojaimi, N Suematsu, S Kinugawa, TH Hintze

FASEB JOURNAL   2006年3月

酸素消費量と一酸化窒素(NO)

絹川 真太郎, 筒井 裕之

循環器専門医 : 日本循環器学会専門医誌   2006年3月

嫌気閾値

絹川 真太郎, 筒井 裕之

循環器専門医 : 日本循環器学会専門医誌   2006年3月

Wassermanの歯車

絹川 真太郎, 筒井 裕之

循環器専門医 : 日本循環器学会専門医誌   2006年3月

Hyperhomocysteinemia alters the cardiac metabolism by impairing nitric oxide bioavailability through oxidative stress

N Suematsu, S Kinugawa, XB Xu, TH Hintze

FASEB JOURNAL   2006年3月

Overexpression of glutathione peroxidase attenuates cardiac remodeling and diastolic dysfunction in diabetic mice

S Matsushima, T Ide, H Matsusaka, M Ikeuchi, T Kubota, K Sunagawa, S Kinugawa, H Tsutsui

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   2005年12月

Overexpression of mitochondrial peroxiredoxin-3 ameliorates left ventricular remodeling and failure after myocardial infarction in mice

S Matsushima, H Matsusaka, M Ikeuchi, T Ide, T Kubota, K Sunagawa, F Hattori, Y Hasagawa, T Kurihara, S Oikawa, S Kinugawa, H Tsutsui

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   2005年12月

Superoxide/endothelial nitric oxide synthase-derived nitric oxide interaction controls substrate utilization during exercise

P Serpillon, S Kinugawa, FA Recchia, TH Hintze

CIRCULATION   2005年10月

A defect of neuronal nitric oxide synthase increases xanthine oxidase derived-superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase

S Kinugawa, HR Huang, ZP Wang, PM Kaminski, MS Wolin, TH Hintze

FASEB JOURNAL   2005年3月

Impaired endothelial nitric oxide production from coronary microvessels induced by cAMP signal transduction in diabetic dog heart

XP Zhang, S Kinugawa, T Hintze

FASEB JOURNAL   2004年3月

Angiotensin II stimulation inhibits modulation of myocardial oxygen consumption by endogenous nitric oxide

S Kinugawa, P Kaminski, H Huang, XB Xu, M Wolin, TH Hintze

FASEB JOURNAL   2003年3月

Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes inhibited by ascorbate and mediated by increased local angiotensin II

S Kinugawa, H Post, XP Zhang, XB Xu, H Huang, FA Recchia, M Ochoa, P Kaminski, M Wolin, TH Hintze

FASEB JOURNAL   2003年3月

Effects of amiodarone on heart cells - Response

H Tsutsui, T Ide, S Kinugawa, A Takeshita, H Utsumi

CIRCULATION   2000年11月

Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury

H Tsutsui, T Ide, S Kinugawa, N Suematsu, H Utsumi

CIRCULATION   1999年11月

Role of oxidative stress in left ventricular remodeling and heart failure after myocardial infarction

S Kinugawa, H Tsutsui, T Ide, S Yamamoto, N Suematsu, S Satoh, H Utsumi, A Takeshita

CIRCULATION   1999年11月

Enhanced myocardial generation of oxygen radicals in heart failure

T Ide, T Tsutsui, S Kinugawa, H Utsumi, N Hattori, K Uchida, H Tagawa

CIRCULATION   1998年10月

Active force development in isolated chemically skinned myocytes are normal in heart failure

S Kinugawa, H Tsutsui, S Satoh, M Takahashi, K IgarashiSaito, H Tagawa

CIRCULATION   1997年10月

日本心臓病学会

日本生化学学会

シンポジウム

日本心不全学術集会  2019年10月 - 2023年6月

マイオカインによる老化進展制御機構の解明

研究課題/領域番号：21H03360  2021年 - 2023年

日本学術振興会  科学研究費助成事業  基盤研究(B)

脳由来神経栄養因子によるミトコンドリア機能制御機構の解明

2018年 - 2020年

日本学術振興会  科学研究費助成事業  基盤研究(B)

心不全モデルマウスにおける運動能力低下および骨格筋異常に対するエンパグリフロジンの保護効果および作用メカニズムの検討

2017年7月 - 2019年7月

受託研究

ナノカプセルを用いた拡張型心筋症に対するミトコンドリアをターゲットとした新規治療法の開発

2016年 - 2017年

日本医療研究開発機構研究費難治性疾患実用化研究事業

骨格筋不全におけるmitoNEETによるミトコンドリア機能制御の分子機構の解明

2014年 - 2016年

日本学術振興会  科学研究費助成事業  基盤研究(C)

メタボリックシンドロームにおける運動能力低下の分子機構の解明と治療への応用

2008年 - 2010年

日本学術振興会  科学研究費助成事業  基盤研究(C)

ミトコンドリア酸化ストレス制御による運動能力改善の新たな治療法の開発

2006年 - 2007年

科学研究費助成事業  若手研究(A,B)

生理機能検査学I、II、III

2023年4月 - 2023年9月   前期

臨床医学III

2023年4月 - 2023年9月   前期

臨床検査学II

2022年10月 - 2023年3月   後期

系統医学II

2022年10月 - 2023年3月   後期

生理機能検査学II,　III

2022年4月 - 2022年9月   前期

臨床医学III

2022年4月 - 2022年9月   前期

臨床検査学講義

2021年10月 - 2022年3月   後期

臨床基本実習

2021年10月 - 2022年3月   後期

系統医学II（循環器）

2021年10月 - 2022年3月   後期

生理機能検査学II,　III

2021年4月 - 2021年9月   前期

臨床医学III

2021年4月 - 2021年9月   前期

系統医学II（循環器）

2020年10月 - 2021年3月   後期