Human microglial cells as a therapeutic target in a neurodevelopmental disease model

Mesci P., LaRock C.N., Jeziorski J.J., Nakashima H., Chermont N., Ferrasa A., Herai R.H., Ozaki T., Saleh A., Snethlage C.E., Sanchez S., Goldberg G., Trujillo C.A., Nakashima K., Nizet V., Muotri A.R.

Stem Cell Reports   19 ( 8 )   1074 - 1091   2024.8   （ ISSN:2213-6711 ）

The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis. International journal

Naoya Murao, Taito Matsuda, Hisae Kadowaki, Yosuke Matsushita, Kousuke Tanimoto, Toyomasa Katagiri, Kinichi Nakashima, Hideki Nishitoh

EMBO reports   25 ( 8 )   3678 - 3706   2024.7   （ ISSN:1469-221X eISSN:1469-3178 ）

Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages

Kunoh, S; Nakashima, H; Nakashima, K

EPIGENOMES   8 ( 2 )   2024.6   （ eISSN:2075-4655 ）

Lineage Reprogramming: Genetic, Chemical, and Physical Cues for Cell Fate Conversion with a Focus on Neuronal Direct Reprogramming and Pluripotency Reprogramming. International journal

Taichi Umeyama, Taito Matsuda, Kinichi Nakashima

Cells   13 ( 8 )   2024.4   （ eISSN:2073-4409 ）

特集 脳と個性 Ⅲ."個性"の実験的理解 エピゲノムと"個性"

渡邉 紗羽, 中嶋 秀行, 中島 欽一

生体の科学   75 ( 1 )   57 - 62   2024.2   （ ISSN:03709531 eISSN:18835503 ）

Mechanism of aberrant brain development induced by exposure to the reverse transcriptase inhibitor during fetal stages

AOYAGI Kei, NAKASHIMA Hideyuki, NAKASHIMA Kinichi

Annual Meeting of the Japanese Society of Toxicology   51.1 ( 0 )   S23-2   2024

Multifaceted Regulation of Neural Stem Cell Fate in the Developing Brain

Takanobu Uotsu, Kinichi Nakashima, Kinichi Nakashima, Sayako Katada

Medical Research Archives   12 ( 3 )   2024   （ ISSN:2375-1916 eISSN:2375-1924 ）

ミクログリア／マクロファージの直接的な神経細胞転換が脳卒中後の神経機能を回復させる Reviewed

Irie T, Matsuda T, Hayashi Y, Matsuda-Ito K, Kamiya A, Masuda T, Prinz M, Isobe N, Kira J.I, Nakashima K

Proc Natl Acad Sci USA   120 ( 42 )   e2307972120   2023.10   （ ISSN:0027-8424 eISSN:1091-6490 ）

胎生期麻酔曝露による神経幹細胞の挙動変化とそのメカニズムの解明

中島 孝輔, 松田 泰斗, 土井 浩義, 山浦 健, 中島 欽一

日本生化学会大会プログラム・講演要旨集   96回   [1T16a - 552)]   2023.10

Reduced neuroinflammation via astrocytes and neutrophils promotes regeneration after spinal cord injury in neonatal mice Invited Reviewed International journal

Kitade K, Kobayakawa K, Saiwai H, Matsumoto Y, Kawaguchi K, Iida K, Kijima K, Iura H, Tamaru T, Haruta Y, Ono G, Konno D, Maeda T, Okada S, Nakashima K, Nakashima Y.

J Neurotrauma   40 ( 23-24 )   2566 - 2579   2023.9   （ ISSN:0897-7151 eISSN:1557-9042 ）

TRK-inhibitor control of an <i>NTRK</i>-rearranged spindle cell tumor with malignant transformation in an adolescent

Higuchi, N; Honda, Y; Koga, Y; Asai, H; Ono, H; Kato, W; Nakashima, K; de la Cuesta, E; Tsujino, T; Yamamoto, H; Kusuhara, K; Hisaoka, M; Ohga, S

PEDIATRIC BLOOD & CANCER   70 ( 9 )   e30379   2023.9   （ ISSN:1545-5009 eISSN:1545-5017 ）

Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. International journal

Takashi Irie, Kanae Matsuda-Ito, Taito Matsuda, Takahiro Masuda, Marco Prinz, Noriko Isobe, Kinichi Nakashima

Genes to cells : devoted to molecular & cellular mechanisms   28 ( 7 )   526 - 534   2023.7   （ ISSN:1356-9597 eISSN:1365-2443 ）

Lineage tracing identifies in vitro microglia -to-neuron conversion by, Invited Reviewed International journal

Irie T, Matsuda-Ito K, Matsuda T, Masuda T, Prinz M, Isoda N, Nakashima K,

Genes Cells 10,   2023.4

特集 生体内リプログラミングによる個体生命機能の制御 リプログラミングによる神経再生

岩本 昌和, 松田 泰斗, 中島 欽一

医学のあゆみ   284 ( 11 )   869 - 874   2023.3   （ ISSN:00392359 ）

Seizure-induced hilar ectopic granule cells in the adult dentate gyrus. International journal

Yuka Kasahara, Hideyuki Nakashima, Kinichi Nakashima

Frontiers in neuroscience   17   1150283 - 1150283   2023.3   （ ISSN:16624548 eISSN:1662-453X ）

C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. Invited Reviewed International journal

J Cancer 14   2023.1

Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition

NAKASHIMA Kinichi, DOI Hiroyoshi, MATSUDA Taito

Annual Meeting of the Japanese Society of Toxicology   50.1 ( 0 )   S31-1   2023

C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions. International journal

Shinjiro Nagao, Hideya Onishi, Makoto Kawamoto, Shogo Masuda, Lin Na, Shinji Morisaki, Naoya Iwamoto, Yutaka Yamada, Satoko Koga, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kinichi Nakashima, Yoshinao Oda, Masafumi Nakamura

Journal of Cancer   14 ( 2 )   306 - 317   2023   （ ISSN:1837-9664 ）

Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types. Invited Reviewed International journal

Kanae Matsuda-Ito, Taito Matsuda, Kinichi Nakashima

Sci Rep   12 ( 1 )   17980 - 17980   2022.10   （ ISSN:2045-2322 ）

Wettability of Molten Fe-Al Alloys Against Oxide Substrates with Various SiO₂ Activity

Furukawa, T; Zhang, ZY; Hirosumi, T; Saito, N; Nakashima, K

TETSU TO HAGANE-JOURNAL OF THE IRON AND STEEL INSTITUTE OF JAPAN   108 ( 8 )   572 - 583   2022.8   （ ISSN:0021-1575 eISSN:1883-2954 ）

脳内免疫担当細胞から神経細胞へのダイレクトリプログラミングによる脳梗塞治療法の開発

中島 欽一

医科学応用研究財団研究報告   39   31 - 36   2022.2   （ ISSN:0914-5117 ）

Wettability of Molten Fe-Al Alloys against Oxide Substrates with Various SiO₂ Activity

Furukawa, T; Zhang, ZY; Hirosumi, T; Saito, N; Nakashima, K

ISIJ INTERNATIONAL   62 ( 7 )   1352 - 1362   2022   （ ISSN:0915-1559 eISSN:1347-5460 ）

Understanding Humanitude Care for Sit-to-stand Motion by Wearable Sensors

An Q., Tanaka A., Nakashima K., Sumioka H., Shiomi M., Kurazume R.

Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics   2022-October   1874 - 1879   2022   （ ISSN:1062922X ISBN:9781665452588 ）

Decreased Lamin B1 Levels Affect Gene Positioning and Expression in Postmitotic Neurons Reviewed International journal

Noguchi, A. Ito, K. Uosaki, Y. Ideta-Otsuka, M. Igarashi, K. Nakashima, H. Kakizaki, T. Kaneda, R. Uosaki, H. Yanagawa, Y. Nakashima, K. Arakawa, H. Takizawa, T.

Neurosci Res   173   22 - 33   2021.12

Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation Reviewed International journal

KAMEDA, T., NAKASHIMA, H., TAKIZAWA, T., MIURA, F., ITO, T., NAKASHIMA, K., IMAMURA T.

J Reprod Dev   67 ( 6 )   369 - 379   2021.12

SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia Reviewed International journal

Takouda, Jun Katada, Sayako Imamura, Takuya Sanosaka, Tsukasa Nakashima, Kinichi

Pharmacol. Res. Perspect.   9   e00749   2021.12

Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration Reviewed International journal

Wakizono T., Nakashima H., Yasui T., Noda T., Aoyagi K., Okada K., Yamada Y., Nakagawa T., Nakashima K.

JCI Insight   2021.11

Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice Reviewed International journal

Parajuli, B. Saito, H. Shinozaki, Y. Shigetomi, E. Miwa, H. Yoneda, S. Tanimura, M. Omachi, S. Asaki, T. Takahashi, K. Fujita, M. Nakashima, K. Koizumi, S.

GLIA   69 ( 10 )   2332 - 2348   2021.10

scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse Reviewed International journal

Wittmann, M.T., Katada,S., Sock, E., Kirchner,P., Ekici, A.B., Wegner, M., Nakashima,K., Lie,2, D.C., Reis, A.

Development   148 ( 14 )   dev196022   2021.7

Generation of ovarian follicles from mouse pluripotent stem cells Reviewed International journal

Yoshino, T., Suzuki, T., Nagamatsu, G., Yabukami, H., Ikegaya, M., Kishima, M., Kita, H., Imamura, T., Nakashima, K., Nishinakamura , R., Tachibana, M., Inoue, M., Shima, Y., Morohashi, K., Hayashi K.

Science   373 ( 6552 )   eabe0237   2021.7

CADM1 and CADM2 triggers neuropathogenic measles virus-mediated membrane fusion by acting in cis Reviewed International journal

Yuta Shirogane, Ryuichi Takemoto, Tateki Suzuki, Tomonori Kameda , Kinichi Nakashima, Takao Hashiguchi, Yusuke Yanagi

J Virol   2021.4

Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury Reviewed International journal

Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Masahide Nakajo, Tatsuya Nagai, Dengli Wang, Masahiro Nishibori, Kinichi Nakashima

Neurosci Res   2021.4

Reconstitution of the oocyte transcriptional network with transcription factors Reviewed International journal

Hamazaki, N. Kyogoku, H. Araki, H. Miura, F. Horikawa, C. Hamada, N. Shimamoto, S. Hikabe, O. Nakashima, K. Kitajima, T. S. Ito, T. Leitch, H. G. Hayashi, K.

Nature   589 ( 7841 )   264 - 269   2021.1

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage Reviewed International journal

Akihide Takeuchi, Yuji Takahashi, Kei Iida, Motoyasu Hosokawa, Koichiro Irie, Mikako Ito, J B Brown, Kinji Ohno, Kinichi Nakashima, Masatoshi Hagiwara

Stem Cell Reports   2020.10

NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes Invited Reviewed International journal

358   104237   2020.10

Enhanced processivity of Dnmt1 by monoubiquitinated histone H3 Reviewed

Yuichi Mishima, Laura Brueckner, Saori Takahashi, Toru Kawakami, Junji Otani, Akira Shinohara, Kohei Takeshita, Ronald Garingalao Garvilles, Mikio Watanabe, Norio Sakai, Hideyuki Takeshima, Charlotte Nachtegael, Atsuya Nishiyama, Makoto Nakanishi, Kyohei Arita, Kinichi Nakashima, Hironobu Hojo, Isao Suetake

Genes to Cells   25 ( 1 )   22 - 32   2020.1

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice. Reviewed International journal

Hirokatsu Saito, Kenshiro Hara, Takashi Tominaga, Kinichi Nakashima, Kentaro Tanemura

Journal of applied toxicology : JAT   39 ( 12 )   1651 - 1662   2019.12

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells. Reviewed

Noguchi H, Castillo JG, Nakashima K, Pleasure SJ

eLife   8   2019.4

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. Reviewed International journal

Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima

Neuron   101 ( 3 )   472 - 485   2019.2

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury. Reviewed

Yoshikawa Y, Ago T, Kuroda J, Wakisaka Y, Tachibana M, Komori M, Shibahara T, Nakashima H, Nakashima K, Kitazono T

Neuroscience   398   193 - 205   2019.2

Rett syndrome and stem cell research

Keita Tsujimura, Kinichi Nakashima

Stem Cell Genetics for Biomedical Research Past, Present, and Future   27 - 41   2018.6

Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury Reviewed

Naohiro Uezono, Yicheng Zhu, Yusuke Fujimoto, Tetsuro Yasui, Taito Matsuda, Masahide Nakajo, Masahiko Abematsu, Takao Setoguchi, Shuji Mori, Hideo K. Takahashi, Setsuro Komiya, Masahiro Nishibori, Kinichi Nakashima

Stem Cells   36 ( 5 )   737 - 750   2018.5

Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression. Reviewed

38 ( 20 )   4791 - 4810   2018.5

Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation Reviewed

Katsunori Semi, Tsukasa Sanosaka, Masakazu Namihira, Kinichi Nakashima

HAYATI Journal of Biosciences   25 ( 2 )   70 - 78   2018.4

Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice Reviewed

Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, Kinichi Nakashima

Proceedings of the National Academy of Sciences of the United States of America   115 ( 16 )   4270 - 4275   2018.4

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells Reviewed

Ayaka Kimura, Taito Matsuda, Atsuhiko Sakai, Naoya Murao, Kinichi Nakashima

Developmental Dynamics   247 ( 1 )   229 - 238   2018.1

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells Reviewed

Yoichiro Kawamura, Jun Takouda, Koji Yoshimoto, Kinichi Nakashima

Cell Biology and Toxicology   1 - 16   2018.1

Neural stem cell therapy aiming at better functional recovery after spinal cord injury Reviewed

Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Kinichi Nakashima

Developmental Dynamics   247 ( 1 )   75 - 84   2018.1

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration Reviewed

Tomonori Kameda, Takuya Imamura, Kinichi Nakashima

Cell and Tissue Research   371 ( 1 )   189 - 199   2018.1

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain Reviewed

Naoya Murao, Shuzo Matsubara, Taito Matsuda, Hirofumi Noguchi, Tetsuji Mutoh, Masahiro Mutoh, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashima

Neuroscience Research   2018.1

Epigenetic Regulation of Human Neural Stem Cell Differentiation

Mizuki Honda, Kinichi Nakashima, Sayako Katada

Results and Problems in Cell Differentiation   125 - 136   2018.1

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury Reviewed

Masahide Nakajo, Naohiro Uezono, Hideyuki Nakashima, Hidenori Wake, Setsuro Komiya, Masahiro Nishibori, Kinichi Nakashima

Neuroscience Research   2018.1

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain Reviewed

Yoichiro Kawamura, Sayako Katada, Hirofumi Noguchi, Hiroyuki Yamamoto, Tsukasa Sanosaka, Koji Iihara, Kinichi Nakashima

FEBS Letters   591 ( 22 )   3709 - 3720   2017.11

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain Reviewed

Yoichiro Kawamura, Sayako Katada, Hirofumi Noguchi, Hiroyuki Yamamoto, Tsukasa Sanosaka, Koji Iihara, Kinichi Nakashima

FEBS LETTERS   591 ( 22 )   3709 - 3720   2017.11

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells Reviewed

Tsukasa Sanosaka, Takuya Imamura, Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, Kinichi Nakashima

CELL REPORTS   20 ( 12 )   2992 - 3003   2017.9

PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells Reviewed

Mizuki Honda, Kinichi Nakashima, Sayako Katada

JOURNAL OF NEUROCHEMISTRY   142 ( 6 )   901 - 907   2017.9

Emerging mechanisms underlying astrogenesis in the developing mammalian brain Reviewed

Jun Takouda, Sayako Katada, Kinichi Nakashima

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES   93 ( 6 )   386 - 398   2017.6

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes Reviewed

Rebecca Brulet, Taito Matsuda, Ling Zhang, Carlos Miranda, Mauro Giacca, Brian K. Kaspar, Kinichi Nakashima, Jenny Hsieh

STEM CELL REPORTS   8 ( 6 )   1506 - 1515   2017.6

Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells Reviewed

Tetsuro Yasui, Naohiro Uezono, Hideyuki Nakashima, Hirofumi Noguchi, Taito Matsuda, Tomoko Noda-Andoh, Hideyuki Okano, Kinichi Nakashima

STEM CELL REPORTS   8 ( 6 )   1743 - 1756   2017.6

Evolutionary acquisition of promoterassociated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals Reviewed

Masahiro Uesaka, Kiyokazu Agata, Takao Oishi, Kinichi Nakashima, Takuya Imamura

BMC GENOMICS   18 ( 1 )   285   2017.4

Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status

Nobuhiko Hamazaki, Kinichi Nakashima, Takuya Imamura

Methods in Molecular Biology   271 - 282   2017.1

Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method

Nobuhiko Hamazaki, Kinichi Nakashima, Katsuhiko Hayashi, Takuya Imamura

Methods in Molecular Biology   83 - 103   2017.1

Reconstitution in vitro of the entire cycle of the mouse female germ line Reviewed

Orie Hikabe, Nobuhiko Hamazaki, Go Nagamatsu, Yayoi Obata, Yuji Hirao, Norio Hamada, So Shimamoto, Takuya Imamura, Kinichi Nakashima, Mitinori Saitou, Katsuhiko Hayashi

NATURE   539 ( 7628 )   299 - +   2016.11

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions Reviewed

Sumiyo Morita, Hirofumi Noguchi, Takuro Horii, Kazuhiko Nakabayashi, Mika Kimura, Kohji Okamura, Atsuhiko Sakai, Hideyuki Nakashitna, Kenichiro Hata, Kinichi Nakashima, Izuho Hatada

NATURE BIOTECHNOLOGY   34 ( 10 )   1060 - 1065   2016.10

Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells Reviewed

Naoki Yamamoto, Kiyokazu Agata, Kinichi Nakashima, Takuya Imamura

NUCLEIC ACIDS RESEARCH   44 ( 11 )   5105 - 5122   2016.6

MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki) Reviewed

Koichiro Irie, Keita Tsujimura, Hideyuki Nakashima, Kinichi Nakashima

JOURNAL OF BIOLOGICAL CHEMISTRY   291 ( 26 )   13891 - 13904   2016.6

DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus Reviewed

Hirofumi Noguchi, Naoya Murao, Ayaka Kimura, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima

JOURNAL OF NEUROSCIENCE   36 ( 22 )   6050 - 6068   2016.6

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation Reviewed

Kenji Ito, Tsukasa Sanosaka, Katsuhide Igarashi, Maky Ideta-Otsuka, Akira Aizawa, Yuichi Uosaki, Azumi Noguchi, Hirokazu Arakawa, Kinichi Nakashima, Takumi Takizawa

SCIENTIFIC REPORTS   6   23903   2016.4

Epigenetic regulation of neural stem cell property from embryo to adult Reviewed

Naoya Murao, Hirofumi Noguchi, Kinichi Nakashima

Neuroepigenetics   5   1 - 10   2016.1

Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood Reviewed

Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Masakazu Namihira, Kinichi Nakashima

Neurogenesis   3 ( 1 )   2016.1

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid Reviewed

Berry Juliandi, Kentaro Tanemura, Katsuhide Igarashi, Takashi Tominaga, Yusuke Furukawa, Maky Otsuka, Noriko Moriyama, Daigo Ikegami, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Minoru Narita, Jun Kanno, Kinichi Nakashima

STEM CELL REPORTS   5 ( 6 )   996 - 1009   2015.12

Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor Reviewed

Akihiro Nakamura, Hiroyuki Funaya, Naohiro Uezono, Kinichi Nakashima, Yasumasa Ishida, Tomohiro Suzuki, Shigeharu Wakana, Tomohiro Shibata

NEUROSCIENCE RESEARCH   100   55 - 62   2015.11

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes Reviewed

Keita Tsujimura, Koichiro Irie, Hideyuki Nakashima, Yoshihiro Egashira, Yoichiro Fukao, Masayuki Fujiwara, Masayuki Itoh, Masahiro Uesaka, Takuya Imamura, Yasukazu Nakahata, Yui Yamashita, Takaya Abe, Shigeo Takamori, Kinichi Nakashima

CELL REPORTS   12 ( 11 )   1887 - 1901   2015.9

Meet our editorial board member Reviewed

Kinichi Nakashima

Current Stem Cell Research and Therapy   10 ( 5 )   373   2015.8

Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus Reviewed

Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima

NEUROSCIENCE RESEARCH   95   1 - 11   2015.6

Akhirin Regulates the Proliferation and Differentiation of Neural Stem Cells in Intact and Injured Mouse Spinal Cord Reviewed

Felemban Athary M. Abdulhaleem, Xiaohong Song, Rie Kawano, Naohiro Uezono, Ayako Ito, Giasuddin Ahmed, Mahmud Hossain, Kinichi Nakashima, Hideaki Tanaka, Kunimasa Ohta

DEVELOPMENTAL NEUROBIOLOGY   75 ( 5 )   494 - 504   2015.5

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage Reviewed

Tomoko Andoh-Noda, Wado Akamatsu, Kunio Miyake, Takuya Matsumoto, Ryo Yamaguchi, Tsukasa Sanosaka, Yohei Okada, Tetsuro Kobayashi, Manabu Ohyama, Kinichi Nakashima, Hiroshi Kurosawa, Takeo Kubota, Hideyuki Okano

MOLECULAR BRAIN   8   31   2015.5

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus Reviewed

Taito Matsuda, Naoya Murao, Yuki Katano, Berry Juliandi, Jun Kohyama, Shizuo Akira, Taro Kawai, Kinichi Nakashima

NATURE COMMUNICATIONS   6   6514   2015.3

Gene activation-associated long noncoding RNAs function in mouse preimplantation development Reviewed

Nobuhiko Hamazaki, Masahiro Uesaka, Kinichi Nakashima, Kiyokazu Agata, Takuya Imamura

DEVELOPMENT   142 ( 5 )   910 - 920   2015.3

Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells

Naoya Murao, Taito Matuda, Hirofumi Noguchi, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashima

Neurogenesis   1 ( 1 )   e976026   2014.11

Transplantation of neural stem cells with valproate for spinal cord injury Reviewed

Masahiko Abematsu, Kinichi Nakashima

Neuroprotection and Regeneration of the Spinal Cord   9784431545026   247 - 253   2014.11

Transplantation of neural stem cells with valproate for spinal cord injury

Masahiko Abematsu, Kinichi Nakashima

Neuroprotection and Regeneration of the Spinal Cord   9784431545026   247 - 253   2014.11

Epigenetic setting and reprogramming for neural cell fate determination and differentiation Reviewed

Takuya Imamura, Masahiro Uesaka, Kinichi Nakashima

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES   369 ( 1652 )   2014.9

VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome Reviewed

Weixiang Guo, Keita Tsujimura, Maky Otsuka, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao

PLOS ONE   9 ( 6 )   e100215   2014.6

Roles of Epigenetics in the Neural Stem Cell and Neuron Reviewed

Naoki Yamamoto, Masahiro Uesaka, Takuya Imamura, Kinichi Nakashima

Epigenetics in Psychiatry   51 - 78   2014.6

Roles of Epigenetics in the Neural Stem Cell and Neuron

Naoki Yamamoto, Masahiro Uesaka, Takuya Imamura, Kinichi Nakashima

Epigenetics in Psychiatry   51 - 78   2014.6

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation Reviewed

Sang-Hoon Yi, Xi-Biao He, Yong-Hee Rhee, Chang-Hwan Park, Takumi Takizawa, Kinichi Nakashima, Sang-Hun Lee

DEVELOPMENT   141 ( 4 )   761 - 772   2014.2

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals Reviewed

Masahiro Uesaka, Osamu Nishimura, Yasuhiro Go, Kinichi Nakashima, Kiyokazu Agata, Takuya Imamura

BMC GENOMICS   15   35   2014.1

Mechanisms of astrocytogenesis in the mammalian brain Reviewed

Masakazu Namihira, Kinichi Nakashima

CURRENT OPINION IN NEUROBIOLOGY   23 ( 6 )   921 - 927   2013.12

Epigenetic regulation of neural stem cell fate during corticogenesis Reviewed

Chai MuhChyi, Berry Juliandi, Taito Matsuda, Kinichi Nakashima

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE   31 ( 6 )   424 - 433   2013.10

Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis Reviewed

Nunung Yuniarti, Berry Juliandi, Chai MuhChyi, Hirofumi Noguchi, Tsukasa Sanosaka, Kinichi Nakashima

NEUROSCIENCE RESEARCH   77 ( 1-2 )   42 - 49   2013.9

Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation Reviewed

Satoshi Urayama, Katsunori Semi, Tsukasa Sanosaka, Yukina Hori, Masakazu Namihira, Jun Kohyama, Takumi Takizawa, Kinichi Nakashima

Cell Structure and Function   38 ( 1 )   55 - 66   2013

Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation Reviewed

Atsushi Saito, Soshi Kanemoto, Noritaka Kawasaki, Rie Asada, Hideo Iwamoto, Mami Oki, Hidetaka Miyagi, Soutarou Izumi, Tsukasa Sanosaka, Kinichi Nakashima, Kazunori Imaizumi

NATURE COMMUNICATIONS   3   967   2012.7

Treatment of a Mouse Model of Spinal Cord Injury by Transplantation of Human Induced Pluripotent Stem Cell-Derived Long-Term Self-Renewing Neuroepithelial-Like Stem Cells Reviewed

Yusuke Fujimoto, Masahiko Abematsu, Anna Falk, Keita Tsujimura, Tsukasa Sanosaka, Berry Juliandi, Katsunori Semi, Masakazu Namihira, Setsuro Komiya, Austin Smith, Kinichi Nakashima

STEM CELLS   30 ( 6 )   1163 - 1173   2012.6

Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1α-notch signal interaction in the developing brain. Reviewed

30 ( 3 )   561 - 569   2012.3

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid Reviewed

Berry Juliandi, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Austin Smith, Kinichi Nakashima

NEUROSCIENCE RESEARCH   72 ( 1 )   23 - 31   2012.1

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb Reviewed

Tomoko Kuwabara, Mohamedi N. Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H. Gage, Makoto Asashima

EMBO MOLECULAR MEDICINE   3 ( 12 )   742 - 754   2011.12

Role of GLI2 in the growth of human osteosarcoma Reviewed

Hiroko Nagao, Kosei Ijiri, Masataka Hirotsu, Yasuhiro Ishidou, Takuya Yamamoto, Satoshi Nagano, Takumi Takizawa, Kinichi Nakashima, Setsuro Komiya, Takao Setoguchi

JOURNAL OF PATHOLOGY   224 ( 2 )   169 - 179   2011.6

L1 retrotransposition in neurons is modulated by MeCP2 Reviewed

Alysson R. Muotri, Maria C. N. Marchetto, Nicole G. Coufal, Ruth Oefner, Gene Yeo, Kinichi Nakashima, Fred H. Gage

NATURE   468 ( 7322 )   443 - 446   2010.11

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury Reviewed

Masahiko Abematsu, Keita Tsujimura, Mariko Yamano, Michiko Saito, Kenji Kohno, Jun Kohyama, Masakazu Namihira, Setsuro Komiya, Kinichi Nakashima

JOURNAL OF CLINICAL INVESTIGATION   120 ( 9 )   3255 - 3266   2010.9

Chromatin remodeling in neural stem cell differentiation Reviewed

Berry Juliandi, Masahiko Abematsu, Kinichi Nakashima

CURRENT OPINION IN NEUROBIOLOGY   20 ( 4 )   408 - 415   2010.8

Epigenetic regulation in neural stem cell differentiation Reviewed

Berry Juliandi, Masahiko Abematsu, Kinichi Nakashima

DEVELOPMENT GROWTH & DIFFERENTIATION   52 ( 6 )   493 - 504   2010.8

Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus Reviewed

Helena Mira, Zoraida Andreu, Hoonkyo Suh, D. Chichung Lie, Sebastian Jessberger, Antonella Consiglio, Juana San Emeterio, Rafael Hortigueela, Maria Angeles Marques-Torrejon, Kinichi Nakashima, Dilek Colak, Magdalena Goetz, Isabel Farinas, Fred H. Gage

CELL STEM CELL   7 ( 1 )   78 - 89   2010.7

BMP-induced REST regulates the establishment and maintenance of astrocytic identity Reviewed

Jun Kohyama, Tsukasa Sanosaka, Akinori Tokunaga, Eriko Takatsuka, Keita Tsujimura, Hideyuki Okano, Kinichi Nakashima

JOURNAL OF CELL BIOLOGY   189 ( 1 )   159 - U220   2010.4

Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification Reviewed

Hirotsugu Asano, Makoto Aonuma, Tsukasa Sanosaka, Jun Kohyama, Masakazu Namihira, Kinichi Nakashima

STEM CELLS   27 ( 11 )   2744 - 2752   2009.11

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis Reviewed

Tomoko Kuwabara, Jenny Hsieh, Alysson Muotri, Gene Yeo, Masaki Warashina, Dieter Chichung Lie, Lynne Moore, Kinichi Nakashima, Makoto Asashima, Fred H. Gage

NATURE NEUROSCIENCE   12 ( 9 )   1097 - U6   2009.9

Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2 Reviewed

Keita Tsujimura, Masahiko Abematsu, Jun Kohyama, Masakazu Namihira, Kinichi Nakashima

EXPERIMENTAL NEUROLOGY   219 ( 1 )   104 - 111   2009.9

Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells Reviewed

Wataru Ochiai, Sayaka Nakatani, Taishi Takahara, Masahiko Kainuma, Makoto Masaoka, Sayaka Minobe, Masakazu Namihira, Kinichi Nakashima, Akira Sakakibara, Masaharu Ogawa, Takaki Miyata

MOLECULAR AND CELLULAR NEUROSCIENCE   40 ( 2 )   225 - 233   2009.2

Epigenetic mechanisms in sequential differentiation of neural stem cells Reviewed

Tsukasa Sanosaka, Masakazu Namihira, Kinichi Nakashima

EPIGENETICS   4 ( 2 )   89 - 92   2009.2

Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.

Namihira Masakazu, Kohyama Jun, Semi Katsunori, Sanosaka Tsukasa, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi

Dev Cell   16 ( 2 )   245 - 255   2009.2

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells Reviewed

Masakazu Namihira, Jun Kohyama, Katsunori Semi, Tsukasa Sanosaka, Benjamin Deneen, Tetsuya Taga, Kinichi Nakashima

DEVELOPMENTAL CELL   16 ( 2 )   245 - 255   2009.2

Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain Reviewed

Jun Kohyama, Takuro Kojima, Eriko Takatsuka, Toru Yamashita, Jun Namiki, Jenny Hsieh, Fred H. Gage, Masakazu Namihira, Hideyuki Okano, Kazunobu Sawamoto, Kinichi Nakashima

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   105 ( 46 )   18012 - 18017   2008.11

Astrocyte-Specific Genes Are Generally Demethylated in Neural Precursor Cells Prior to Astrocytic Differentiation Reviewed

Izuho Hatada, Masakazu Namihira, Sumiyo Morita, Mika Kimura, Takuro Horii, Kinichi Nakashima

PLOS ONE   3 ( 9 )   e3189   2008.9

Epigenetic mechanisms regulating fate specification of neural stem cells Reviewed

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES   363 ( 1500 )   2099 - 2109   2008.6

[Epigenetic regulation involved in fate specification of neural cells]. Reviewed

Sanosaka T, Tsujimura K, Nakashima K

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   53 ( 4 Suppl )   331 - 337   2008.3

Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain Reviewed

Wenwu Li, Guoqiang Sun, Su Yang, Qiuhao Qu, Kinichi Nakashima, Yanhong Shi

MOLECULAR ENDOCRINOLOGY   22 ( 1 )   56 - 64   2008.1

Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells Reviewed

Shinji Fukuda, Masahiko Abematsu, Hiroyuki Mori, Makoto Yanagisawa, Tetsushi Kagawa, Kinichi Nakashima, Akihiko Yoshimura, Tetsuya Taga

MOLECULAR AND CELLULAR BIOLOGY   27 ( 13 )   4931 - 4937   2007.7

Bcl-X-L/Bax proteins direct the fate of embryonic cortical precursor cells Reviewed

Mi-Yoon Chang, Woong Sun, Wataru Ochiai, Kinichi Nakashima, Soo-Young Kim, Chang-Hwan Park, Jin Sun Kang, Jae-Won Shim, A-Young Jo, Chun-Sik Kang, Yong-Sung Lee, Jae-Sang Kim, Sang-Hun Lee

MOLECULAR AND CELLULAR BIOLOGY   27 ( 12 )   4293 - 4305   2007.6

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline Reviewed

Sebastian Jessberger, Kinichi Nakashima, Gregory D. Clemenson, Eunice Mejia, Emily Mathews, Kerstin Ure, Shiori Ogawa, Christopher M. Sinton, Fred H. Gage, Jenny Hsieh

JOURNAL OF NEUROSCIENCE   27 ( 22 )   5967 - 5975   2007.5

Conversion of mammalian Müller glial cells into a neuronal lineage by in vitro aggregate-culture. Reviewed

351 ( 2 )   514 - 520   2006.12

Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons Reviewed

Hiroki Setoguchi, Masakazu Namihira, Jun Kohyama, Hirotsugu Asano, Tsukasa Sanosaka, Kinichi Nakashima

JOURNAL OF NEUROSCIENCE RESEARCH   84 ( 5 )   969 - 979   2006.10

Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3 Reviewed

Makoto Ohno, Jun Kohyama, Masakazu Namihira, Tsukasa Sanosaka, Jun A. Takahashi, Nobuo Hashimoto, Kinichi Nakashima

CYTOKINE   36 ( 1-2 )   17 - 22   2006.10

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells Reviewed

Atsushi Suzuki, Angel Raya, Yasuhiko Kawakami, Masanobu Morita, Takaaki Matsui, Kinichi Nakashima, Fred H. Gaget, Concepcion Rodriguez-Esteban, Juan Carlos Izpisua Belmonte

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   103 ( 27 )   10294 - 10299   2006.7

Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation Reviewed

Basam Z. Barkho, Hongjun Song, James B. Aimone, Richard D. Smrt, Tomoko Kuwabara, Kinichi Nakashima, Fred H. Gage, Xinyu Zhao

STEM CELLS AND DEVELOPMENT   15 ( 3 )   407 - 421   2006.6

Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs. Reviewed

Abematsu M, Smith I, Nakashima K

Current stem cell research & therapy   1 ( 2 )   267 - 277   2006.5

Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification Reviewed

Nature Clinical Practice Cardiovascular Medicine   3 ( 1 )   S114 - S122   2006.3

Development of functional human embryonic stem cell-derived neurons in mouse brain Reviewed

AR Muotri, K Nakashima, N Toni, VM Sandler, FH Gage

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   102 ( 51 )   18644 - 18648   2005.12

Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture Reviewed

M Yanagisawa, K Nakashima, W Ochiai, T Takizawa, T Setoguchi, A Uemura, M Takizawa, Nobuhisa, I, T Taga

NEUROSCIENCE RESEARCH   53 ( 2 )   176 - 182   2005.10

Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells Reviewed

K Shimozaki, M Namihira, K Nakashima, T Taga

JOURNAL OF NEUROCHEMISTRY   93 ( 2 )   432 - 439   2005.4

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells Reviewed

J Hsieh, K Nakashima, T Kuwabara, E Mejia, FH Gage

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   101 ( 47 )   16659 - 16664   2004.11

Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor Reviewed

T Setoguchi, K Nakashima, T Takizawa, M Yanagisawa, W Ochiai, M Okabe, K Yone, S Komiya, T Taga

EXPERIMENTAL NEUROLOGY   189 ( 1 )   33 - 44   2004.9

Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter Reviewed

M Namihira, K Nakashima, T Taga

FEBS LETTERS   572 ( 1-3 )   184 - 188   2004.8

Cell fusion-independent differentiation of neural stem cells to the endothelial lineage Reviewed

AE Wurmser, K Nakashima, RG Summers, N Toni, KA D'Amour, DC Lie, FH Gage

NATURE   430 ( 6997 )   350 - 356   2004.7

[Mechanism of neural stem cell fate specification] Reviewed

Nakashima K

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   49   718 - 726   2004.5

Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan. Reviewed

Chijiwa T, Deshimaru M, Nobuhisa I, Nakai M, Ogawa T, Oda N, Nakashima K, Fukumaki Y, Shimohigashi Y, Hattori S, Ohno M

Biochem J   347 ( Pt 2 )   491 - 400   2004.4

A small modulatory dsRNA specifies the fate of adult neural stem cells Reviewed

T Kuwabara, J Hsieh, K Nakashima, K Taira, FH Gage

CELL   116 ( 6 )   779 - 793   2004.3

IGF-1 instructs multipotent adult neural progenitor cells to become oligodendrocytes Reviewed

J Hsieh, JB Aimone, BK Kaspar, T Kuwabara, K Nakashima, FH Gage

JOURNAL OF CELL BIOLOGY   164 ( 1 )   111 - 122   2004.1

Expression and function of orphan nuclear receptor TLX in adult neural stem cells Reviewed

YH Shi, DC Lie, P Taupin, K Nakashima, J Ray, RT Yu, FH Gage, RM Evans

NATURE   427 ( 6969 )   78 - 83   2004.1

Embryonic stem cells: staying plastic on plastic Reviewed

K Nakashima, S Colamarino, FH Gage

NATURE MEDICINE   10 ( 1 )   23 - 24   2004.1

Enhanced gene activation by Notch and BMP signaling cross-talk Reviewed

T Takizawa, W Ochiai, K Nakashima, T Taga

NUCLEIC ACIDS RESEARCH   31 ( 19 )   5723 - 5731   2003.10

Enhanced gene activation by Notch and BMP signaling cross-talk.

Takizawa Takumi, Ochiai Wataru, Nakashima Kinichi, Taga Tetsuya

Nucleic Acids Res   31 ( 19 )   5723 - 5731   2003.10

Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures Reviewed

K Shimozaki, K Nakashima, H Niwa, T Taga

DEVELOPMENT   130 ( 11 )   2505 - 2512   2003.6

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function Reviewed

XY Zhao, T Ueba, BR Christie, B Barkho, MJ McConnell, K Nakashima, ES Lein, BD Eadie, AR Willhoite, AR Muotri, RG Summers, J Chun, KF Lee, FH Gage

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   100 ( 11 )   6777 - 6782   2003.5

Requirement of gp130 signaling for the AGM hematopoiesis Reviewed

M Takizawa, Nobuhisa, I, K Igarashi, M Ueno, K Nakashima, T Kitamura, T Taga

EXPERIMENTAL HEMATOLOGY   31 ( 4 )   283 - 289   2003.4

Interisland evolution of Trimeresurus flavoviridis venom phospholipase A(2) isozymes Reviewed

T Chijiwa, Y Yamaguchi, T Ogawa, M Deshimaru, Nobuhisa, I, K Nakashima, N Oda-Ueda, Y Fukumaki, S Hattori, M Ohno

JOURNAL OF MOLECULAR EVOLUTION   56 ( 3 )   286 - 293   2003.3

The role of gp130 in cerebral cortical development: In vivo functional analysis in a mouse exo utero system Reviewed

T Hatta, K Moriyama, K Nakashima, T Taga, H Otani

JOURNAL OF NEUROSCIENCE   22 ( 13 )   5516 - 5524   2002.7

Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system Reviewed

K Nakashima, T Taga

MOLECULAR NEUROBIOLOGY   25 ( 3 )   233 - 244   2002.6

Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3 Reviewed

A Uemura, T Takizawa, W Ochiai, M Yanagisawa, K Nakashima, T Taga

CYTOKINE   18 ( 1 )   1 - 7   2002.4

Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues Reviewed

N Kimura, M Takizawa, K Okita, O Natori, K Igarashi, M Ueno, K Nakashima, Nobuhisa, I, T Taga

GENES TO CELLS   7 ( 4 )   435 - 446   2002.4

DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain Reviewed

T Takizawa, K Nakashima, M Namihira, W Ochiai, A Uemura, M Yanagisawa, N Fujita, M Nakao

DEVELOPMENTAL CELL   1 ( 6 )   749 - 758   2001.12

Traumatic injury-induced BMP7 expression in the adult rat spinal cord Reviewed

T Setoguchi, K Yone, E Matsuoka, H Takenouchi, K Nakashima, T Sakou, S Komiya, S Izumo

BRAIN RESEARCH   921 ( 1-2 )   219 - 225   2001.12

Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 Reviewed

M Yanagisawa, K Nakashima, K Takeda, W Ochiai, T Takizawa, M Ueno, M Takizawa, H Shibuya, T Taga

GENES TO CELLS   6 ( 12 )   1091 - 1099   2001.12

Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins Reviewed

M Yanagisawa, T Takizawa, W Ochiai, A Uemura, K Nakashima, T Taga

NEUROSCIENCE RESEARCH   41 ( 4 )   391 - 396   2001.12

Brain from bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent Reviewed

J Kohyama, H Abe, T Shimazaki, A Koizumi, K Nakashima, S Gojo, T Taga, H Okano, J Hata, A Umezawa

DIFFERENTIATION   68 ( 4-5 )   235 - 244   2001.10

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion Reviewed

M Ueno, K Igarashi, N Kimura, K Okita, M Takizawa, Nobuhisa, I, T Kojima, T Kitamura, U Samulowitz, D Vestweber, T Shimomura, T Suda, K Nakashima, T Taga

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   287 ( 2 )   501 - 506   2001.9

Ligand recognition by the vitamin D receptor Reviewed

MW Choi, K Yamamoto, H Masuno, K Nakashima, T Taga, S Yamada

BIOORGANIC & MEDICINAL CHEMISTRY   9 ( 7 )   1721 - 1730   2001.7

Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3 Reviewed

W Ochiai, M Yanagisawa, T Takizawa, K Nakashima, T Taga

CYTOKINE   14 ( 5 )   264 - 271   2001.6

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis Reviewed

K Nakashima, T Takitawa, W Ochiai, M Yanagisawa, T Hisatsune, M Nakafuku, K Miyazono, T Kishimoto, R Kageyama, T Taga

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   98 ( 10 )   5868 - 5873   2001.5

Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 Reviewed

T Takizawa, M Yanagisawa, W Ochiai, K Yasukawa, T Ishiguro, K Nakashima, T Taga

CYTOKINE   13 ( 5 )   272 - 279   2001.3

Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines Reviewed

M Yanagisawa, K Nakashima, T Takizawa, W Ochiai, H Arakawa, T Taga

FEBS LETTERS   489 ( 2-3 )   139 - 143   2001.2

A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody Reviewed

R Matsuo, W Ochiai, K Nakashima, T Taga

JOURNAL OF IMMUNOLOGICAL METHODS   247 ( 1-2 )   141 - 151   2001.1

Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons Reviewed

H Kato, S Chen, H Kiyama, K Ikeda, N Kimura, K Nakashima, T Taga

JOURNAL OF BIOCHEMISTRY   128 ( 6 )   923 - 932   2000.12

Cell density-dependent regulation of hepatic development by a gp 130-independent pathway Reviewed

N Kojima, T Kinoshita, A Kamiya, K Nakamura, K Nakashima, T Taga, A Miyajima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   277 ( 1 )   152 - 158   2000.10

Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1 Reviewed

M Ueno, N Kimura, K Nakashima, F Saito-Ohara, J Inazawa, T Taga

GENE   254 ( 1-2 )   29 - 35   2000.8

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 Reviewed

N Kimura, R Matsuo, H Shibuya, K Nakashima, T Taga

JOURNAL OF BIOLOGICAL CHEMISTRY   275 ( 23 )   17647 - 17652   2000.6

Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3 Reviewed

M Yanagisawa, K Nakashima, H Arakawa, K Ikenaka, K Yoshida, T Kishimoto, T Hisatsune, T Taga

JOURNAL OF NEUROCHEMISTRY   74 ( 4 )   1498 - 1504   2000.4

Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan Reviewed

Chijiwa T, Deshimaru M, Nobuhisa I, Nakai M, Ogawa T, Oda N, Nakashima K, Fukumaki Y, Shimohigashi Y, Hattori S, Ohno M

Biochemical Journal   347   491 - 499   2000.4

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain Reviewed

K Yamamoto, H Masuno, M Choi, K Nakashima, T Taga, H Ooizumi, K Umesono, W Sicinska, J VanHooke, HF DeLuca, S Yamada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   97 ( 4 )   1467 - 1472   2000.2

Astrocyte differentiation mediated by LIF in cooperation with BMP2 Reviewed

K Nakashima, M Yanagisawa, H Arakawa, T Taga

FEBS LETTERS   457 ( 1 )   43 - 46   1999.8

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains Reviewed

N Kimura, M Ueno, K Nakashima, T Taga

JOURNAL OF BIOCHEMISTRY   126 ( 1 )   180 - 187   1999.7

STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M Reviewed

M Yanagisawa, K Nakashima, T Taga

NEUROSCIENCE LETTERS   269 ( 3 )   169 - 172   1999.7

Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation Reviewed

K Nakashima, S Wiese, M Yanagisawa, H Arakawa, N Kimura, T Hisatsune, K Yoshida, T Kishimoto, M Sendtner, T Taga

JOURNAL OF NEUROSCIENCE   19 ( 13 )   5429 - 5434   1999.7

A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain Reviewed

N Kimura, K Nakashima, M Ueno, H Kiyama, T Taga

DEVELOPMENTAL BRAIN RESEARCH   115 ( 2 )   183 - 193   1999.6

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer Reviewed

A Kamiya, T Kinoshita, Y Ito, T Matsui, Y Morikawa, E Senba, K Nakashima, T Taga, K Yoshida, T Kishimoto, A Miyajima

EMBO JOURNAL   18 ( 8 )   2127 - 2136   1999.4

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 Reviewed

K Nakashima, M Yanagisawa, H Arakawa, N Kimura, T Hisatsune, M Kawabata, K Miyazono, T Taga

SCIENCE   284 ( 5413 )   479 - 482   1999.4

Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: Their sequence comparison to the respective rat homologs Reviewed

Chieko Aoyama, Kinichi Nakashima, Kozo Ishidate

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism   1393 ( 1 )   179 - 185   1998.7

gp130 and the IL-6 family of cytokines: Signaling mechanisms and thrombopoietic activities Reviewed

K Nakashima, T Taga

SEMINARS IN HEMATOLOGY   35 ( 3 )   210 - 221   1998.7

Retrotransposable CR1-like elements in crotalinae snake genomes Reviewed

Nobuhisa, I, T Ogawa, M Deshimaru, T Chijiwa, K Nakashima, Y Chuman, Y Shimohigashi, Y Fukumaki, S Hattori, M Ohno

TOXICON   36 ( 6 )   915 - 920   1998.6

Structures of genes encoding phospholipase A(2) inhibitors from the serum of Trimeresurus flavoviridis snake Reviewed

Nobuhisa, I, M Deshimaru, T Chijiwa, K Nakashima, T Ogawa, Y Shimohigashi, Y Fukumaki, S Hattori, H Kihara, M Ohno

GENE   191 ( 1 )   31 - 37   1997.5

Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130 Reviewed

K Nakashima, M Narazaki, T Taga

FEBS LETTERS   403 ( 1 )   79 - 82   1997.2

Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130 Reviewed

K Nakashima, M Narazaki, T Taga

FEBS LETTERS   401 ( 1 )   49 - 52   1997.1

Accelerated evolution of snake venom phospholipase A(2) isozymes for acquisition of diverse physiological functions Reviewed

T Ogawa, K Nakashima, Nobuhisa, I, M Deshimaru, Y Shimohigashi, Y Fukumaki, Y Sakaki, S Hattori, M Ohno

TOXICON   34 ( 11-12 )   1229 - 1236   1996.11

Accelerated evolution of crotalinae snake venom gland serine proteases Reviewed

M Deshimaru, T Ogawa, KI Nakashima, Nobuhisa, I, T Chijiwa, Y Shimohigashi, Y Fukumaki, M Niwa, Yamashina, I, S Hattori, M Ohno

FEBS LETTERS   397 ( 1 )   83 - 88   1996.11

Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A(2) isozyme-encoding genes Reviewed

Nobuhisa, I, K Nakashima, M Deshimaru, T Ogawa, Y Shimohigashi, Y Fukumaki, Y Sakaki, S Hattori, H Kihara, M Ohno

GENE   172 ( 2 )   267 - 272   1996.6

Roles of lysine-69 in dimerization and activity of Trimeresurus flavoviridis venom aspactate-49-phospholipase A(2) Reviewed

S Nakamura, M Nakai, K Nakashima, T Ogawa, Y Shimohigashi, M Ohno, H Kihara, T Yamane, T Ashida

JOURNAL OF MOLECULAR RECOGNITION   9 ( 1 )   23 - 30   1996.1

Molecular evolution of group II phospholipases A(2) Reviewed

T Ogawa, M Kitajima, K Nakashima, Y Sakaki, M Ohno

JOURNAL OF MOLECULAR EVOLUTION   41 ( 6 )   867 - 877   1995.12

LYSINE-49-PHOSPHOLIPASES A(2) FROM TRIMERESURUS-FLAVOVIRIDIS VENOM ARE MEMBRANE-ACTING ENZYMES Reviewed

Y SHIMOHIGASHI, A TANI, H MATSUMOTO, K NAKASHIMA, Y YAMAGUCHI, N ODA, Y TAKANO, H KAMIYA, J KISHINO, H ARITA, M OHNO

JOURNAL OF BIOCHEMISTRY   118 ( 5 )   1037 - 1044   1995.11

PURIFICATION AND PRIMARY STRUCTURE OF A MYOTOXIC LYSINE-49 PHOSPHOLIPASE A(2) WITH LOW LIPOLYTIC-ACTIVITY FROM TRIMERESURUS-GRAMINEUS VENOM Reviewed

M NAKAI, K NAKASHIMA, T OGAWA, Y SHIMOHIGASHI, S HATTORI, CC CHANG, M OHNO

TOXICON   33 ( 11 )   1469 - 1478   1995.11

ACCELERATED EVOLUTION IN THE PROTEIN-CODING REGIONS IS UNIVERSAL IN CROTALINAE SNAKE-VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES Reviewed

KI NAKASHIMA, NOBUHISA, I, M DESHIMARU, M NAKAI, T OGAWA, Y SHIMOHIGASHI, Y FUKUMAKI, M HATTORI, Y SAKAKI, S HATTORI, M OHNO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   92 ( 12 )   5605 - 5609   1995.6

Structures of Genes Encoding TATA Box-binding Proteins from Trimeresurus gramineus and T. flavoviridis Snakes Reviewed

NAKASHIMA K, NOBUHISA I, DESHIMARU M, OGAWA T, SHIMOHIGASHI Y, FUKUMAKI Y, HATTORI M, SAKAKI Y, HATTORI S, OHNO M

Gene   152 ( 2 )   209 - 213   1995.1

Trimeresurus flavoviridis venom gland phospholipase A(2) isozymes genes have evolved via accelerated substitutions Reviewed

T OGAWA, KI NAKASHIMA, N ODA, Y SHIMOHIGASHI, M OHNO, S HATTORI, M HATTORI, Y SAKAKI, H KIHARA

JOURNAL OF MOLECULAR RECOGNITION   8 ( 1-2 )   40 - 46   1995.1

POLYMORPHISMS OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES Reviewed

KI NAKASHIMA, NOBUHISA, I, T OGAWA, M HATTORI, Y SAKAKI, H KIHARA, M OHNO

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   58 ( 8 )   1510 - 1511   1994.8

Darwinian Evolution of Trimeresurus flavoviridis Gland Phospholipase A2 Isozymes Invited Reviewed

NAKASHIMA K, OGAWA T, ODA N, SHIMOHIGASHI Y, HATTORI M, SAKAKI Y, KIHARA H, OHNO M

Pure & Applied Chemistry   66 ( 4 )   715 - 720   1994.4

PURIFICATION, SEQUENCING AND CHARACTERIZATION OF SINGLE AMINO ACID-SUBSTITUTED PHOSPHOLIPASE-A(2) ISOZYMES FROM TRIMERESURUS-GRAMINEUS (GREEN HABU SNAKE) VENOM Reviewed

T FUKAGAWA, T NOSE, Y SHIMOHIGASHI, T OGAWA, N ODA, K NAKASHIMA, CC CHANG, M OHNO

TOXICON   31 ( 8 )   957 - 967   1993.8

ACCELERATED EVOLUTION OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE-A2 ISOZYMES Reviewed

K NAKASHIMA, T OGAWA, N ODA, M HATTORI, Y SAKAKI, H KIHARA, M OHNO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   90 ( 13 )   5964 - 5968   1993.7

REFOLDING OF TRIMERESURUS-FLAVOVIRIDIS PHOSPHOLIPASES-A2 Reviewed

S TSUNO, T OGAWA, K NAKASHIMA, N ODA, SM LEE, Y SHIMOHIGASHI, H AOYAGI, M OHNO

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   65 ( 10 )   2655 - 2659   1992.10

UNUSUALLY HIGH CONSERVATION OF UNTRANSLATED SEQUENCES IN CDNAS FOR TRIMERESURUS-FLAVOVIRIDIS PHOSPHOLIPASE-A2 ISOZYMES Reviewed

T OGAWA, N ODA, K NAKASHIMA, H SASAKI, M HATTORI, Y SAKAKI, H KIHARA, M OHNO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   89 ( 18 )   8557 - 8561   1992.9

Cloning and sequence analysis of cDNA for Trimeresurus flavoviridis phospholipase A2 isozymes : Unusually high conservation of untranslated region sequences

Ogawa, T, Nakashima, K, Oda, N, Ohno, M, Sasaki, H, Hattori, M, Sakaki, Y, Kihara, H

Recent Advances in Toxinology Research   1   549 - 556   1992.4

内在性DNAを介したミクログリア活性化による広凡性発達障害レット症候群発症の可能性

中嶋秀行、中島欽一

第55回日本発生生物学会  2022.6 

miR-199aを介したBMP-Smadシグナル阻害によるレット症候群原因因子MeCP2の神経幹細胞分化制御

中島欽一

第94回日本生化学会大会  2021.11 

レット症候群原因因子MeCP2欠損による神経幹細胞分化バランス異常のメカニズム

中島欽一、中嶋秀行

日本人類遺伝学会第66回大会 第28回日本遺伝子診療学会大会合同開催  2021.10 

レット症候群原因因子MeCP2のmiRNAを介した神経幹細胞分化制御機構

中島欽一

第６４回日本神経化学会大会  2021.9 

MeCP2 controls neural stem cell fate specification through microRNA-mediated inhibition of BMP-Smad signaling

2021.7 

Artificially-induced neurogenesis and its therapeutic application to injury in the adult central nervous systems

2021.5 

ミクログリアからニューロンへの直接分化転換による脳梗塞治療法の開発

中島欽一

2021.3 

レット症候群原因因子MeCP2のマイクロRNAを介した神経幹細胞分化制御機構の解明

中島欽一

第47回日本毒性学会学術年会  2020.6 

レット症候群原因因子MeCP2のmiRNAを介した神経幹細胞分化制御機構の解明 Invited

中島欽一

第19回日本再生医療学会総会  2020.3 

ミクログリアからニューロンへのダイレクトリプログラミングによる脳梗塞治療法の開発 Invited

中島欽一

第19回日本再生医療学会総会  2020.3 

Artificial neurogenesis in the adult central nervous systems and its effects on functional recovery after injury Invited International conference

Kinichi Nakashima

2nd Neuroepigenetics & Neuroepitranscriptomics  2020.3 

人為的新生ニューロン補充による成体中枢神経系損傷治療法開発の試み Invited

中島欽一

先端モデル動物支援プラットフォーム  2020.2 

人為的ニューロン新生誘導による神経系機能修復の試み Invited

中島欽一

みらい研究公開シンポジウム  2020.1 

Artificial Production of New Neurons in the Adult Central Nervous System

Cell&Cene Therapy Asia 2019  2019.11 

Prior inhibition of HMGB1enhances human neural stem cell transplantation-mediated functional recovery after spinal cord injury Invited International conference

9th International DAMPs and Alarmins Symposium  2019.11 

転写因子NeuroD1によるミクログリアからニューロンへのダイレクトリプログラミングのメカニズム Invited

中島欽一

第９１回日本遺伝学会  2019.9 

生体神経組織における人為的ニューロン新生とその作用 Invited

中島欽一

第43回蛋白質と酵素の構造と機能に関する九州シンポジウム  2019.9 

転写因子 ND1によるミクログリアからニューロンへのダイレクトリプログラミングの分子基盤 Invited

中島欽一

第46回日本毒性学会学術年会  2019.6 

胎生期バルプロ酸曝露によるけいれん感受性増大のメカニズムとその改善法 Invited

中島欽一

第46回日本毒性学会学術年会  2019.6 

成体神経系組織における人為的ニューロン新生

中島欽一

第１５回成体脳ニューロン新生懇談会  2019.2 

転写因子 NeuroD1によるミクログリアからニューロンへの分化転換とそのメカニズム

中島欽一

第41回日本分子生物学会年会  2018.11 

転写因子ND1によるミクログリアからニューロンへの直接分化転換メカニズムの解明 Invited

中島欽一

神経発達・再生研究会  2018.10 

損傷部保全と神経幹細胞移植の併用による脊髄損傷治療法の開発

中島欽一

2018.10 

Preservation of the injured site boosts up neural stem cell transplantation-mediated functional recovery after spinal cord injury

2018.9 

Interplay between cell extrinsic cues and intrinsic epigenetic programs in the regulation of developmental stage-dependent fate spevification of neural stem cells

2018.7 

神経系のエピジェネティクスとその変遷

中島欽一

第95回日本生理学会大会  2018.3 

酸素濃度によるヒト神経幹細胞分化のエピジェネティック制御

中島欽一

日本薬学会  2018.3 

胎生期エピジェネティック撹乱による遅発性学習記憶障害とてんかん感受性増加のメカニズム Invited

中島欽一

第26回海馬と高次脳機能学会  2017.9 

Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells Invited

The 72nd Fujihara Seminar Molecular Mechanism of Molding and Disruption of the Epigenomes Underlying Cellular Community  2017.9 

DNA Methylation Regulting Neuron-Glia Fate Switching of Neural Stem Cells

2017.7 

Insights into Rett Syndrome using Neural Stem Cell Invited International conference

Kinichi Nakashima

KEYSTONE SYMPOSIA  2017.1 

移植医療・再生医療　細胞移植及び生体内直接分化転換による中枢神経系機能の再生

中島 欽一

日本病理学会会誌  2024.2  (一社)日本病理学会

胎生期麻酔曝露による神経幹細胞の挙動変化とそのメカニズムの解明

中島 孝輔, 松田 泰斗, 土井 浩義, 山浦 健, 中島 欽一

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

精神・神経疾患発症のメカニズム解明と治療に向けたエピジェネティック・アプローチ　内在性DNAリガンドによるミクログリア活性化を介したレット症候群発症機構

中嶋 秀行, 中島 欽一

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

移植医療・再生医療　細胞移植及び生体内直接分化転換による中枢神経系機能の再生

中島 欽一

日本病理学会会誌  2024.2  (一社)日本病理学会

神経幹細胞の増殖再開の可否を規定するG0期誘導の分子基盤解明

野村 真優子, 松田 泰斗, 和泉 自泰, 松田 花菜江, 馬場 健史, 中島 欽一

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

母体免疫活性化による自閉スペクトラム症様病態誘発機序の解明とその改善法の創出

岡田 可南子, 中嶋 秀行, 中島 欽一

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

エピジェネティクス研究の新機軸～モデル動物からヒトまで～　幼児期ミダゾラム曝露による遅発性認知機能低下の分子基盤解明とその改善法

中島 欽一, 土井 浩義, 松田 泰斗

The Journal of Toxicological Sciences  2023.6  (一社)日本毒性学会

ダイレクロリプログラミングによる失われた神経系機能の改善法

中島孝輔、松田泰斗、松田花菜江、入江剛史、中島欽一

月刊細胞   2023.9

【神経の再生-臨床に届く基礎研究】ダイレクトリプログラミングによる失われた神経系機能の改善法

中島 孝輔, 松田 泰斗, 松田 花菜江, 入江 剛史, 中島 欽一

細胞   55 ( 10 )   774 - 777   2023.9   （ ISSN:1346-7557 ）

ダイレクトリプログラミングによる失われた神経系機能の改善法—Improving impaired neurological function through direct programming—特集 神経の再生 : 臨床に届く基礎研究

中島 孝輔, 松田 泰斗, 松田 花菜江, 入江 剛史, 中島 欽一

細胞   55 ( 10 )   774 - 777   2023.9   （ ISSN:1346-7557 ）

Seizure-induced hilar ectopic granule cells in the adult dentate gyrus Reviewed

Yuka Kasahara, Hideyuki Nakashima, Kinichi Nakashima

2023.3

リプログラミングによる神経再生 Reviewed

岩本昌和、松田泰斗、中島欽一

医学のあゆみ　Vol.284、No.11、869-874   2023.3

【生体内リプログラミングによる個体生命機能の制御】リプログラミングによる神経再生

岩本 昌和, 松田 泰斗, 中島 欽一

医学のあゆみ   284 ( 11 )   869 - 874   2023.3   （ ISSN:0039-2359 ）

胎生期麻酔曝露による神経幹細胞の挙動変化とそのメカニズムの解明

中島孝輔, 中島孝輔, 松田泰斗, 土井浩義, 山浦健, 中島欽一

日本生化学会大会(Web)   96th   2023

幼若期の麻酔薬暴露が将来的な認知機能障害を誘発するメカニズムの解明 Reviewed

松田泰斗、土井浩義、中島欽一

実験医学 Vol.40、No.4、588-2591   2022.2

Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders Reviewed

Taito Matsuda Kinichi Nakashima

Neurosci Res   2021.5

Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors Reviewed

Shuzo Matsubara, Taito Matsuda, Kinichi Nakashima

Cells   2021.5

メチル化DNA結合タンパク異常症 Reviewed

中嶋秀行、青柳圭、岡田可南子、中島欽一

遺伝子医学MOOK Vo.36、99-104   2021.4

ミクログリアへの遺伝子導入. Reviewed

入江剛史、松田泰斗、中島欽一

実験医学別冊105-112   2020.11

ダイレクトリプログラミングによるミクログリアから神経細胞への運命転換. Reviewed

松田花菜江、松田泰斗、中島欽一

ダイレクトリプログラミング   2020.8

ミクログリアから機能的な神経細胞へのダイレクトリプログラミング

松田泰斗, 中島欽一

2019.5

エピジェネティクスを介したヒト多能性細胞由来神経幹/前駆細胞のアストロサイト分化能獲得における酸素濃度の影響

安井徹郎, 中島欽一

2019.2

Hypoxia epigenetically bestows astrocytic differentiation potential on human pluripotent cell-derived neural stem/precursor cells

Tetsuro Yasui, Kinichi Nakashima

Folia Pharmacologica Japonica   2019.1

低用量ペルメトリン早期慢性暴露によるマウス次世代雄個体行動影響

斉藤洋克, 原健士朗, 冨永貴志, 中島欽一, 種村健太郎

日本内分泌かく乱化学物質学会研究発表会要旨集   2018.12

アセチル化

山下りえ, 堅田明子, 中島欽一

2018.9

子どもへの低用量化学物質暴露が誘発する情動認知行動影響とその評価系の開発 幼若期ネオニコチノイド投与が成体マウス脳トランスクリプトームに及ぼす影響

今村 拓也, 亀田 朋典, 松田 泰斗, 土井 浩義, 古川 佑介, 種村 健太郎, 中島 欽一

2018.6

子どもへの低用量化学物質暴露が誘発する情動認知行動影響とその評価系の開発 幼若期ネオニコチノイド投与が成体マウス脳トランスクリプトームに及ぼす影響

今村 拓也, 亀田 朋典, 松田 泰斗, 土井 浩義, 古川 佑介, 種村 健太郎, 中島 欽一

2018.6

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

Tomonori Kameda, Takuya Imamura, Kinichi Nakashima

Cell and Tissue Research   2018.1

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

Yoichiro Kawamura, Jun Takouda, Koji Yoshimoto, Kinichi Nakashima

Cell Biology and Toxicology   2018.1

Neural stem cell therapy aiming at better functional recovery after spinal cord injury

Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Kinichi Nakashima

Developmental Dynamics   2018.1

Manipulation of Promoter-Associated Noncoding RNAs in Mouse Early Embryos for Controlling Sequence-Specific Epigenetic Status

Hamazaki, N. Nakashima, K. Imamura, T.

Methods Mol Biol   2017.4

レット症候群病態に重要なMeCP2の新機能：MeCP2によるmicroRNAプロセシングを介したmTORシグナル制御

辻村啓太, 中島欽一

2017.4

Detection of Bidirectional Promoter-Derived lncRNAs from Small-Scale Samples Using Pre-Amplification-Free Directional RNA-seq Method

Hamazaki, N. Nakashima, K. Hayashi, K. Imamura, T.

Methods Mol Biol   2017.4

Emerging mechanisms underlying astrogenesis in the developing mammalian brain

Jun Takouda, Sayako Katada, Kinichi Nakashima

Proceedings of the Japan Academy Series B: Physical and Biological Sciences   2017.1

Novel function of MeCP2 in the pathophysiology of Rett syndrome Regulation of mTOR signaling mediated by MeCP2-dependent microRNA processing

Keita Tsujimura, Kinichi Nakashima

Seikagaku. The Journal of Japanese Biochemical Society   2017.1

Epigenetic regulation of neural stem cell property from embryo to adult

Naoya Murao, Hirofumi Noguchi, Kinichi Nakashima

Neuroepigenetics   2016.1

Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus

Taito Matsuda, Kinichi Nakashima

Neurogenesis   2015.1

Epigenetic setting and reprogramming for neural cell fate determination and differentiation

Takuya Imamura, Masahiro Uesaka, Kinichi Nakashima

Philosophical Transactions of the Royal Society B: Biological Sciences   2014.1

Epigenetic mechanisms regulating differentiation of neural stem/precursor cells

Aliya Mari D. Adefuin, Ayaka Kimura, Hirofumi Noguchi, Kinichi Nakashima, Masakazu Namihira

Epigenomics   2014.1

Mechanisms of astrocytogenesis in the mammalian brain

Masakazu Namihira, Kinichi Nakashima

Current Opinion in Neurobiology   2013.12

Epigenetic regulation of neural stem cell fate during corticogenesis

Chai MuhChyi, Berry Juliandi, Taito Matsuda, Kinichi Nakashima

International Journal of Developmental Neuroscience   2013.10

妊娠期投与による胎生期バルプロ酸暴露マウスは学習記憶異常と海馬抑制系の減弱を示す

冨永 貴志, 冨永 洋子, 五十嵐 勝秀, 種村 健太郎, 菅野 純, 中島 欽一

2012.7

アストロサイト分化における小胞体ストレス応答の役割(The role of endoplasmic reticulum stress response in astrocyte differentiation)

齋藤 敦, 落合 希実子, 村上 智彦, 佐野坂 司, 中島 欽一, 和中 明生, 今泉 和則

神経化学   2010.8

Glucocorticoid induces expression of astrocyte marker GFAP mRNA in mouse neural stem cells

Jun Kanno, Katsuhide Igarashi, Kentaro Tanemura, Hirotugu Asano, Kinichi Nakashima

ENDOCRINE JOURNAL   2010.3

神経系細胞分化を制御するエピジェネティクス機構

中島欽一, 神山淳, 波平昌一, Gage Fred H, 岡野栄之, 澤本和延

脳と発達   2009.11

脊髄損傷に対するエピジェネティック治療

あべ松昌彦, 辻村啓太, 山野眞利子, 斉藤美知子, 河野憲二, 神山淳, 波平昌一, 小宮節郎, 中島欽一

日本整形外科学会雑誌   2009.8

成体脳におけるニューロン新生の分子メカニズム (特集 海馬ニューロンの新生--精神疾患と神経機能への関与)

切替郁枝, 松井恵, 中島欽一

メディカルバイオ   2009.3

神経新生・幹細胞の生物学 REST/NRSFを介した骨形成因子BMPによる新規ニューロン分化抑制機構(A inhibitory mechanism of neuronal differentiation mediated by BMP-induced REST/NRSF)

中島 欽一, 神山 淳, 高塚 絵里子, 佐野坂 司, 徳永 暁憲, 岡野 栄之

神経化学   2008.8

バルプロ酸の持つ新たな薬理作用 : 神経幹細胞の増殖・分化制御

松昌彦, 中島欽一

日本薬理学雑誌   2008.5

神経細胞の誕生・幹細胞 神経系細胞の分化制御とエピジェネティクス (神経の分化,回路形成,機能発現) -- (神経の発生と分化)

佐野坂司, 辻村啓太, 中島欽一

蛋白質核酸酵素   2008.3

エピジェネティクス機構による神経幹細胞の分化制御

波平昌一, 中島欽一

生化学   2008.2

エピジェネティクスにより制御される神経幹細胞運命決定機構

神山淳, 中島欽一

2007.7

ヒストン脱アセチル化酵素阻害剤バルプロ酸による神経幹細胞分化制御機構の解明と損傷脊髄再生治療への応用

あべ松昌彦, 辻村啓太, 神山淳, 波平昌一, 瀬戸口啓夫, 米和徳, 小宮節郎, 五十嵐勝秀, 菅野純, 中島欽一

2007.7

神経幹細胞運命決定におけるエピジェネティクスの重要性 (特集 幹細胞新世紀--ES細胞・体性幹細胞の新たなポテンシャル)

神山淳, 中島欽一

細胞工学   2007.5

神経系とクロマチン (細胞核の世界--ダイナミクスから病態まで) -- (クロマチンリモデリングと転写)

波平昌一, 中島欽一

蛋白質核酸酵素   2006.11

Special Review 神経系細胞におけるエピジェネティックな遺伝子発現調節機構

大野誠, 中島欽一

細胞工学   2006.6

生命現象との関わり 2.幹細胞分化とエピジェネティクス―神経幹細胞をモデルとして

神山淳, 高塚絵理子, 中島欽一

実験医学   2006.5

エピジェネティクスと神経幹細胞分化制御 (第1土曜特集 神経保護・再生医療研究の最前線) -- (神経再生)

神山淳, 中島欽一

医学のあゆみ   2005.12

Notchシグナルによる発生段階依存的な神経幹細胞成熟機構の解析

波平昌一, 神山淳, 青沼真, 瀬戸口広貴, 田賀哲也, 中島欽一

日本分子生物学会年会講演要旨集   2005.11

レチノイン酸とLIFによる神経幹細胞の相乗的アストロサイト分化誘導

青沼真, 波平昌一, 瀬戸口広貴, 神山淳, 中島欽一

日本分子生物学会年会講演要旨集   2005.11

メチル化DNA結合蛋白質による神経系細胞分化可塑性制御機構の解析

瀬戸口広貴, 波平昌一, 青沼真, 神山淳, 中島欽一

日本分子生物学会年会講演要旨集   2005.11

メチル化DNA結合タンパク質による神経系細胞分化可塑性制御

神山淳, 黒見靖, 瀬戸口広貴, 波平昌一, 中島欽一

日本分子生物学会年会講演要旨集   2005.11

DNA methylation regulating neural cell fate specification

Jun Kohyama, Yasushi Kuromi, Masakazu Namihira, Jenny Hsieh, Fred H. Gage, Kinichi Nakashima

CELL STRUCTURE AND FUNCTION   2005.6

神経幹細胞多分化能獲得機構の解析

波平昌一, 神山淳, 田賀哲也, 中島欽一

日本発生生物学会大会発表要旨集   2005.5

サイトカインや核内因子による脳細胞分化の制御 (特集 脳の発生分化と回路形成)

波平昌一, 中島欽一, 田賀哲也

神経研究の進歩   2005.2

ハブ毒ホスホリパーゼA₂アイソザイムの島内および島間多様性の比較

千々岩崇仁, 弟子丸正伸, 信久幾夫, 中島欽一, 小川智久, 服巻保幸, 服部正策, 小田(上田)直子, 大野素徳

日本分子生物学会年会プログラム・講演要旨集   2004.11

神経幹細胞の系譜制御機構 (特集 幹細胞の運命を決定するシグナル)

中島欽一

蛋白質核酸酵素   2004.5

DNA methylation-mediated regulation of astrocyte differentiation from neural precursor cells in mouse fetal brain

M Namihira, K Nakashima, T Takizawa, T Taga

JOURNAL OF NEUROCHEMISTRY   2004.2

Stage- and site-specific DNA demethylation in neural stem cells generated from embryonic stem cells

K Shimozaki, M Namihira, K Nakashima, T Taga

JOURNAL OF NEUROCHEMISTRY   2004.2

DNA methylation-mediated regulation of astrocyte differentiation from neural stem cell in mouse fetal brain

M Namihira, K Nakashima, T Takizawa, T Taga

JOURNAL OF NEUROCHEMISTRY   2003.12

Regulation of cell fate-specific DNA methylation in astrocyte differentiation from ES cells

K Shimozaki, M Namihira, K Nakashima, T Taga

JOURNAL OF NEUROCHEMISTRY   2003.12

Indispensable role of gp130 signaling in the AGM hematopoiesis.

M Takizawa, Nobuhisa, I, K Igarashi, M Ueno, K Nakashima, T Taga

BLOOD   2003.11

Neurogenin1は神経幹細胞においてintegrinα5の発現を抑制する

村松大, 吉田真子, 中島欽一, 宮本有正, 久恒辰博

日本農芸化学会大会講演要旨集   2003.3

神経系とサイトカイン (特集 サイトカインを知ろう)

瀬戸口啓夫, 中島欽一, 田賀哲也

救急医学   2002.12

神経幹細胞の分化制御 (再生医学・再生医療) -- (第2部 幹細胞の分化制御)

滝沢琢己, 中島欽一, 田賀哲也

現代化学増刊   2002.7

サイトカインによる細胞系譜制御機構

中島欽一, 柳澤亮, 滝沢琢己

臨床免疫   2001.10

マウスAGM造血期におけるgp130シグナルの役割

滝沢牧子, 信久幾夫, 五十嵐勝秀, 上野将也, 沖田圭介, 井上博文, 中島欽一, 田賀哲也

日本免疫学会総会・学術集会記録   2001.10

Cytokine-mediated cell fate modulation in the developing brain

K Nakashima, T Takizawa, W Ochiai, M Yanagisawa, T Taga

JOURNAL OF NEUROCHEMISTRY   2001.9

インターロイキン6のシグナル伝達機構 (特集 免疫学研究の最新動向)

田賀哲也, 中島欽一

学術月報   2001.7

ニューロン分化に関与する遺伝子 (特集 脳の発達に関与する分子機構)

田賀哲也, 滝沢琢己, 中島欽一

生体の科学   2001.5

ビタミンD受容体リガンド結合領域の三次元構造構築とリガンドドッキング

山本恵子, 増野弘幸, 崔美花, 中島欽一, 田賀哲也, 大泉宏, 梅園和彦, SicinskaWanda, VanHookeJaneen, DeLucaHector F, 山田幸子

ビタミン   2000.9

IL-6ファミリーサイトカインとBMPファミリーサイトカインのシグナルクロストークによる細胞系譜制御

田賀哲也, 中島欽一

歯科基礎医学会雑誌   2000.8

胎生10.5日マウスdorsal aortaで発現する分泌蛋白と膜蛋白のcDNAクローニング

上野将也, 五十嵐勝秀, 木村直紀, 沖田圭介, 滝沢牧子, 北村俊雄, 中島欽一, 田賀哲也

生化学   2000.8

日本南西諸島におけるハブ毒腺ホスホリパーゼA2アイソザイムの孤立による進化

千々岩 崇仁, 弟子丸 正伸, 信久 幾夫, 中井 誠, 小川 智久, 小田 直子, 中島 欽一, 服巻 保幸, 下東 康之, 服部 正策

生化学   2000.8

神経系におけるBMPの役割 (特集 骨形成因子"BMP"--形づくりから臨床応用まで)

中島欽一, 田賀哲也

モレキュラ-メディシン   2000.6

IL‐6ファミリーサイトカインによる胎生期マウス神経上皮細胞のアストロサイトへの分化誘導とその分子機構

柳沢亮, 中島欽一, 木村直紀, 池中一裕, 久恒辰博, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1999.11

LIFとBMP2のシグナルクロストークによる未分化神経上皮細胞の分化制御

中島欽一, 柳沢亮, 荒川浩一, 木村直紀, 久恒辰博, 今村健志, 川畑正博, 宮園浩平, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1999.11

IL-6ファミリーサイトカインにより活性化されるSTAT3セリンキナーゼの解析

中島欽一, 楢崎雅司, 松尾律子, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

運動ニューロン損傷時に発現される新規遺伝子のクローニング

加藤博明, 陳実, 木村直紀, 中島欽一, 木山博資, 池田憲, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

未分化神経上皮細胞のアストロサイト分化誘導におけるgp130刺激性サイトカインとBMPによる相乗効果

中島欽一, 柳澤亮, 木村直紀, 久恒辰博, 吉田寛二, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

新規T-box遺伝子Tbr2, および新規Lhx遺伝子ebs71の脳神経構築における役割

木村直紀, 上野将也, 中島欽一, 木山博資, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

マウス胎仔脳で特異的に発現する新規T-box遺伝子Tbr2の単離およびそのゲノム構造解析

上野将也, 木村直紀, 中島欽一, 木山博資, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

インターロイキン11により誘導される未分化神経上皮細胞のアストロサイトへの分化

柳澤亮, 荒川浩一, 中島欽一, 木村直紀, 久恒辰博, 吉田寛二, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

gp130欠損マウスにおける多様な神経系異常

中島欽一, 柳澤亮, 木村直紀, 久恒辰博, 吉田寛二, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.12

インターロイキンIIにより誘導される未分化神経上皮細胞のアストロサイトへの分化

柳沢亮, 荒川浩一, 中島欽一, 木村直紀, 久恒辰博, 吉田寛二, 田賀哲也

日本分子生物学会年会プログラム・講演要旨集   1998.11

サイトカイン受容体 (特集 受容体と疾患--基礎と臨床)

中島欽一, 田賀哲也

現代医療   1998.1

Two distinct pathways that mediate gp130-induced cell proliferation; SHP-2-p42/p44 map kinase pathway and state pathway.

M Narazaki, K Nakashima, T Kishimoto, T Taga

TISSUE ANTIGENS   1996.10

ハブ血清ホスホリパーゼA_2インヒビターの遺伝子構造

信久幾夫, 弟子丸正伸, 千々岩崇仁, 中島欽一, 小川智久, 服巻保幸, 服部正策, 下東康幸, 大野素徳

日本分子生物学会年会プログラム・講演要旨集   1996.8

マムシ亜科ヘビ毒腺トロンビン様酵素アイソザイムの加速進化

弟子丸正伸, 小川智久, 中島欽一, 下東康幸, 服巻保幸, 榊佳之, 服部正策, 大野素徳

化学関連支部合同九州大会講演予稿集   1995.7

ヘビ毒腺ホスホリパーゼA₂アイソザイムの加速進化による多機能獲得

中島欽一, 小川智久, 信久幾夫, 弟子丸正伸, 中井誠, 下東康幸, 服部正策, 大野素徳

生体機能関連化学シンポジウム講演要旨集   1995.5

ヘビ毒腺アイソザイムは加速進化により新しい機能を獲得している

中島欽一, 小川智久, 大野素徳

化学と生物   1994.11

ヘビ毒腺ホスホリパーゼA₂アイソザイムの適応進化による多機能獲得のタンパク質工学的解析

小川智久, 松村操, 中島欽一, 下東康幸, 服巻保幸, 榊佳之, 木原大, 大野素徳

日本分子生物学会年会プログラム・講演要旨集   1994.11

グリーンハブ毒腺塩基性Lys‐49‐ホスホリパーゼA₂の精製と一次構造

中井誠, 中島欽一, 野瀬健, 小川智久, 下東康幸, 張均昌, 大野素徳

化学関連支部合同九州大会講演予稿集   1994.7

ヒメハブ毒ホスホリパーゼA₂アイソザイムcDNA及び遺伝子のクローニング

信久幾夫, 中島欽一, 小川智久, 下東康幸, 服巻保幸, 榊佳之, 服部正策, 木原大, 大野素徳

化学関連支部合同九州大会講演予稿集   1994.7

ハブ属異種ヘビ間におけるホスホリパーゼA₂アイソザイム遺伝子の比較

中島欽一, 小川智久, 下東康幸, 服巻保幸, 服部正平, 榊佳之, 木原大, 大野素徳

化学関連支部合同九州大会講演予稿集   1994.7

II型ホスホリパーゼA₂の分子進化

小川智久, 北島正人, 中島欽一, 榊佳之, 大野素徳

日本分子生物学会年会プログラム・講演要旨集   1993.11

ハブ毒腺ホスホリパーゼA₂アイソザイムの機能の多様性と適応進化

小川智久, 中島欽一, 小田直子, 下東康幸, 服部正平, 榊佳之, 木原大, 大野素徳

タンパク質構造討論会講演要旨集   1993.9

ハブ毒ホスホリパーゼA₂アイソザイム遺伝子の多様性及び構造解析

中島欽一, 小川智久, 小田直子, 大野素徳, 服部正平, 榊佳之, 木原大

化学関連支部合同九州大会講演予稿集   1992.7

日本神経科学学会

日本分子生物学会

日本エピジェネティクス研究会

Society for Neuroscience

International Society for Stem Cell Research

日本エピジェネティクス研究会   広報委員長   Domestic

2012.5 - 2017.4   

Neuroscience Research International contribution

Role(s)： Peer review

2017.1 - 2023.12

その他

第8回神経発生討論会  （ 九州大学コラボステーション Japan ） 2015.3

その他

第７回日本エピジェネティクス研究会年会  （ 奈良県新公会堂 Japan ） 2013.5

Stem Cells International contribution

Role(s)： Peer review

2006.5 - 2023.4

環境変化誘発性精神・神経疾患の発症共通原理の解明ならびに完全非侵襲的細胞置換による治療法の創出

2020 - 2025

革新的先端研究開発支援事業ユニットタイプ

Study for the early prediction system for the neurobehavioral toxicity induced by chemical exposure during development

Grant number：19H01142  2019.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

Tanemura Kentaro

認知症に関与するマイクロバイオーム・バイオメーカー解析の研究

2019 - 2022

厚生労働科学研究費補助金 (厚生労働省）

完全非侵襲的新生ニューロン補充による新規脳梗塞治療法の創出

2019 - 2021

再生医療実現拠点ネットワークプログラム

ミクログリア－ニューロン直接分化転換機構の解明と新規脊髄損傷治療法開発の試み

Grant number：19K22473  2019 - 2020

日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

ゲノム編集技術を用いたモデル動物作出による精神神経筋疾患の病態解明

2018.4 - 2021.3

受託研究

家庭用品化学物質が周産期の中枢神経系に及ぼす遅発性毒性の評価系作出に資する研究

2018 - 2020

厚生労働科学研究費補助金 (厚生労働省）

非神経細胞とマイクロRNA生合成撹乱の観点から探る神経発達障害発症の分子基盤解明

Grant number：17H01390  2017 - 2020

日本学術振興会  科学研究費助成事業  基盤研究(A)

個性を創発する神経幹細胞におけるエピジェネティックメモリーとその制御

Grant number：16H06527  2016 - 2020

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

「個性」創発脳システムの統合的理解を拓く国際的データシェアプラットフォームの構築

Grant number：16K21734 

大隅 典子, 保前 文高, 若林 明雄, 中島 欽一, 星野 幹雄, 今吉 格, 郷 康広, 冨永 貴志, 駒木 文保, 柴田 智広

応用幹細胞学

2022.10 - 2023.3   Second semester

医学研究特論Ⅱ

2022.4 - 2022.9   First semester

生命の科学A

2022.4 - 2022.9   First semester

分子医学概論

2022.4 - 2022.9   First semester

基礎生物学

2022.4 - 2022.9   First semester

応用幹細胞学

2021.10 - 2022.3   Second semester

生体情報機能学Ⅱ

2021.10 - 2022.3   Second semester

基礎生物学

2021.4 - 2021.9   First semester

分子医学概論

2021.4 - 2021.9   First semester

医学研究特論Ⅱ

2020.10 - 2021.3   Second semester

生命の科学A

2020.10 - 2021.3   Second semester

応用幹細胞学

2020.10 - 2021.3   Second semester

生体情報機能学Ⅱ

2020.10 - 2021.3   Second semester

基礎生物学

2020.4 - 2020.9   First semester

分子医学概論

2020.4 - 2020.9   First semester

生体情報機能学Ⅱ-②

2019.10 - 2020.3   Second semester

応用幹細胞学

2019.10 - 2020.3   Second semester

分子医学概論

2019.4 - 2019.9   First semester

生命の科学A

2019.4 - 2019.9   First semester

分子生物学概論

2019.4 - 2019.9   First semester

生体情報機能学Ⅱ-②

2018.10 - 2019.3   Second semester

応用幹細胞学

2018.10 - 2019.3   Second semester

分子生物学概論

2018.4 - 2018.9   First semester

分子医学概論

2018.4 - 2018.9   First semester

医学研究特論II

2018.4 - 2018.9   First semester

応用幹細胞学

2017.10 - 2018.3   Second semester

生命の科学A

2017.6 - 2017.8   Summer quarter

生命の科学A

2017.4 - 2017.9   First semester

分子医学概論

2017.4 - 2017.9   First semester

分子生物学概論

2017.4 - 2017.9   First semester

生体情報機能学Ⅱ

2016.10 - 2017.3   Second semester

応用幹細胞学

2016.10 - 2017.3   Second semester

分子医学概論

2016.4 - 2016.9   First semester

生命の科学A

2016.4 - 2016.9   First semester

応用幹細胞学

2015.10 - 2016.3   Second semester