MATSUDA TAITO
Organization
Faculty of Medical Sciences Department of Stem Cell Biology and Medicine Lecturer
School of Medicine Department of Medicine（Joint Appointment）
Title
Lecturer
Contact information
Tel
0926426196
Degree
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Doctor of Medicine
Research Interests・Research Keywords
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Research theme：Identify the factors inducing the impairment of neural stem cell proliferation during aging
Keyword：Neural stem cell
Research period： 2018.4 - 2022.5
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Research theme：Direct reprogramming of microglia into neurons
Keyword：direct reprogramming
Research period： 2018.4 - 2021.5
Awards
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エピジェネティクス研究会奨励賞
2020.4 エピジェネティクス研究会 成体脳における自然/人為的なニューロン新生のエピジェネティック制御
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神経科学会奨励賞
2020.4 日本神経科学会 成体脳における「自然／人為的な」ニューロン新生
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井上研究奨励賞
2016.2 井上科学振興財団 ミクログリアのTLR9はてんかん発作依存的な海馬異常ニューロン新生を抑制する
Papers
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Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke Invited Reviewed International journal
Takashi Irie, Taito Matsuda*, Yoshinori Hayashi, Kanae Matsuda-Ito, Akihide Kamiya, Takahiro Masuda, Marco Prinz, Noriko Isobe, Jun-ichi Kira, and Kinichi Nakashima*
Proc Natl Acad Sci USA 2024.5
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Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. Invited Reviewed International journal
Takashi Irie*, Kanae Matsuda-Ito*, Taito Matsuda#, Takahiro Masuda, Marco Prinz, Noriko Isobe, Kinichi Nakashima#
Gene to Cells 2023.4
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Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types. Invited Reviewed International journal
Kanae Matsuda-Ito#, Taito Matsuda#* (equal first authorship, co-corresponding author) & Kinichi Nakashima*
Scientific Reports 2022.10
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Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition Reviewed International journal
Doi H#., Matsuda T#* (equal first authorship, co-corresponding author)., Sakai A., Matsubara S., Hoka S., Yamaura K. & Nakashima K*.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118 ( 38 ) 2021.9
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Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion Reviewed International journal
Matsuda T * (co-corresponding author)., Irie T., Katsurabayashi S., Hayashi Y., Nagai T., Hamazaki N., Adefuin AMD., Miura F., Ito T., Kimura H., Shirahige K., Takeda T., Iwasaki K., Imamura T. & Nakashima K*.
Neuron 2019.1
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Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Reviewed International journal
Murao N., Matsubara S., Matsuda T., Noguchi H., Mutoh T., Mutoh M., Koseki H., Namihira M. & Nakashima K.
Neurosci Res 2018.8
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Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice Reviewed International journal
Proc Natl Acad Sci USA 2018.4
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Prior treatment with anti-High Mobility Group Box-1 antibody boosts human neural stem cell transplantation-mediated functional recovery after spinal cord injury Reviewed International journal
Uezono N., Zhu Y., Fujimoto Y., Yasui T., Matsuda T., Nakajo M., Abematsu M., Setoguchi T., Mori S., Takahashi H.K., Komiya S., Nishibori M. & Nakashima K.
Stem Cells 2018.3
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HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells. Reviewed International journal
Kimura A., Matsuda T* (co-corresponding author)., Sakai A., Murao N. & Nakashima K*.
Deve Dyn 2017.8
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Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells Reviewed International journal
5. Yasui T., Uezono N., Nakashima H, Noguchi H., Matsuda T., Noda-Andoh T., Okano H. & Nakashima K
Stem Cell Reports 2017.6
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NEUROD1 instructs neuronal conversion in non-reactive astrocytes Reviewed International journal
Brulet R., Matsuda T., Zhang L., Miranda C., Giacca M., Kaspar B.K., Nakashima K. & Hsieh J.
Stem Cell Reports 2017.3
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DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus. Reviewed International journal
Noguchi H., Murao N., Kimura A., Matsuda T., Namihira M. & Nakashima K.
J. Neurosci 2016.5
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TLR9 signaling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus Reviewed International journal
Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K
Nat Commun 2015.3
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Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα. Invited Reviewed International journal
2011.1
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Taito Matsuda, Kinichi Nakashima
Neurogenesis 2 ( 1 ) 2015.1
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Epigenetic regulation of neural stem cell fate during corticogenesis Reviewed
Chai MuhChyi, Berry Juliandi, Taito Matsuda, Kinichi Nakashima
International Journal of Developmental Neuroscience 31 ( 6 ) 424 - 433 2013.10
Presentations
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ミクログリアからニューロンへのダイレクトリプログラミングによる脳梗塞治療
松田泰斗
第63回神経化学会 2020.9
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成体マウス脳ミクログリアから機能的なニューロンへのダイレクトリプログラミング
松田 泰斗
第43回神経科学会 2020.7
MISC
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Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders. Reviewed
Matsuda T*. & Nakashima K
Neuroscience Research 2021.6
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Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors. Reviewed
Matsubara S., Matsuda T*. & Nakashima K*
Cells 2021.6
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In vivo direct reprogramming as a therapeutic strategy for brain and retina repair Reviewed
Sekiryu H. & Matsuda T*.
Neural Regeneration 2021.6
Professional Memberships
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The Japanese society for Epigenetics
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The Japane Neuroscience Sciety
Research Projects
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幹細胞老化機構の解明とリプログラミングに基づく健康脳機能の再生
Grant number：23K18451 2023 - 2024
日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）
Authorship：Principal investigator Grant type：Scientific research funding
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腸内細菌による異所性ニューロン新生誘発の分子基盤解明とてんかん治療法創出
Grant number：21H02808 2021 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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腸内細菌による異所性ニューロン新生誘発の分子基盤解明とてんかん治療法創出
Grant number：21H02808 2021 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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神経幹細胞エイジングを誘発する最初期因子の同定
Grant number：18K14820 2018 - 2020
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding