Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal Reviewed International journal

Fumio Arai, Patrick S Stumpf, Yoshiko M Ikushima, Kentaro Hosokawa, Aline Roch, Matthias P Lutolf, Toshio Suda, Ben D MacArthur

CELL SYSTEMS   11 ( 6 )   640 - +   2020.12

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45(-) TER119(-) Erythroid and Lymphoid Progenitors Invited Reviewed International journal

Kazuhito Gotoh, Yuya Kunisaki, Soichi Mizuguchi, Daiki Setoyama, Kentaro Hosokawa, Hisayuki Yao, Yuya Nakashima, Mikako Yagi, Takeshi Uchiumi, Yuichiro Semba, Jumpei Nogami, Koichi Akashi, Fumio Arai, Dongchon Kang

ISCIENCE   23 ( 11 )   2020.11

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes International journal

Sakamoto H, Takeda N, Fumio Arai, Hosokawa Kentaro, Garcia P, Suda T, Frampton J, Ogawa M

Stem Cells   2015.2

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.

Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa Kentaro, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Oike Y

Arterioscler Thromb Vasc Biol.   2014.4

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.

Yamashita M, Nitta E, Nagamatsu Go, Ikushima YM, Hosokawa Kentaro, Fumio Arai, Suda T

Biochem Biophys Res Commun.   2013.11

Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.

Ikushima YM, Hosokawa Kentaro, Fumio Arai, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T

Blood.   2013.3

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.

Ikushima YM, Fumio Arai, Nakamura Y, Hosokawa Kentaro, Kubota Y, Hirashima M, Toyama H, Suda T

Biochem Biophys Res Commun.   2013.1

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.

Toyama H, Fumio Arai, Hosokawa Kentaro, Ikushima YM, Suda T

Biochem Biophys Res Commun.   2012.11

p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.

Zou P, Yoshihara H, Hosokawa Kentaro, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Keiichi Nakayama, Suda T

Cell Stem Cell.   2011.9

Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.

Nitta E, Yamashita M, Hosokawa Kentaro, Xian M, Takubo K, Fumio Arai, Nakada S, Suda T

Blood.   2011.4

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.

Nakamura Y, Fumio Arai, Iwasaki H, Hosokawa Kentaro, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T

Blood.   2010.8

骨中コラーゲン高親和性タンパク質の骨芽細胞様細胞株MC3T3-E1細胞の骨形成過程に及ぼす影響. Reviewed

村上 拡治, @細川 健太郎, 祭 友昭, 笠井 久隆, 井上 順雄

日本保健科学学会誌   12 ( 4 )   237 - 244   2010.3

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.

Gomei Y, Nakamura Y, Yoshihara H, Hosokawa Kentaro, Iwasaki H, Suda T, Fumio Arai

Exp Hematol.   2010.2

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.

Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa Kentaro, Fumio Arai, Takahashi T, Suda T

Biochem Biophys Res Commun.   2009.1

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

Matsuoka S, Oike Y, Onoyama I, Iwama A, Fumio Arai, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa Kentaro, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Keiichi Nakayama, Suda T

Genes Dev.   2008.4

Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

Yoshihara H, Fumio Arai, Hosokawa Kentaro, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T

Cell Stem Cell.   2007.12

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto K, Araki KY, Naka K, Fumio Arai, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa Kentaro, Nakauchi H, Nakayama K, Keiichi Nakayama, Harada M, Motoyama N, Suda T, Hirao A

Cell Stem Cell.   2007.6

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

Ito K, Takubo K, Fumio Arai, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa Kentaro, Ikeda Y, Mak TW, Suda T, Hirao A

J Immunol.   2007.1

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

Ito K, Hirao A, Fumio Arai, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa Kentaro, Ikeda Y, Suda T

Nat Med.   2006.4

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

Ito K, Hirao A, Fumio Arai, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa Kentaro, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T

Nature.   2004.10

造血幹細胞の未分化性維持に対する転写因子Foxp2の機能解析

Grant number：17K09907  2017 - 2019

日本学術振興会  科学研究費助成事業  基盤研究(C)

シングルセル統合解析による新規間葉系幹細胞の同定と造血制御能の解明

Grant number：15K15366  2015 - 2016

科学研究費助成事業  挑戦的萌芽研究

医学系研究奨励・基礎「テロメア結合性因子による造血幹細胞の体外増幅技術の開発」

2015

がん研究助成「Shelterin分子複合体を標的とした白血病幹細胞の形成抑制技術の開発」

2015

テロメア結合蛋白POT1の増強によるヒト造血幹細胞の体外増幅技術への挑戦

Grant number：25670453  2013 - 2014

科学研究費助成事業  挑戦的萌芽研究

造血幹細胞における細胞競合を介した増殖制御機構の解明

Grant number：24689041  2012 - 2014

科学研究費助成事業  若手研究(A)

造血および白血病幹細胞ニッチの分子機構とその制御

Grant number：23249053  2011 - 2013

日本学術振興会  科学研究費助成事業  基盤研究(A)

研究助成「POT1の増強による造血幹細胞の体外増幅法の開発」

2011

造血幹細胞の単一細胞単位での非対称分裂機構の解析

Grant number：22790920  2010 - 2011

科学研究費助成事業  若手研究(B)

血液医学研究助成「造血幹細胞の単一細胞単位における非対称分裂機構の解析」

2010

骨髄内ニッチによる造血幹細胞制御機構の解明

Grant number：07J02999  2007 - 2008

日本学術振興会  科学研究費助成事業  特別研究員奨励費

骨髄内ニッチによる造血幹細胞制御機構の解明

2007 - 2008

日本学術振興会  特別研究員