Updated on 2024/08/27

Information

 

写真a

 
TAKAHASHI EIKI
 
Organization
Faculty of Medical Sciences Research Center for Human Disease Modeling Professor
Faculty of Medical Sciences Research Center for Human Disease Modeling(Concurrent)
Environmental Control Center for Experimental Biology (Concurrent)
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Title
Professor
Contact information
メールアドレス
Profile
Studies have been focused on generation of animal models for neuronal disorders and analyses of a molecular cascade that links nutritional environment to neuronal disease risk.
External link

Degree

  • PhD

Research History

  • 1994年4月 エーザイ株式会社創薬研究所

    1994年4月 エーザイ株式会社創薬研究所

  • 2006年7月 理化学研究所脳科学総合研究センター動物実験支援ユニット 専門職研究員 2008年4月 理化学研究所脳科学総合研究センター動物実験支援ユニット ユニットリーダー 2011年4月 理化学研究所脳科学総合研究センター動物資源開発支援ユニット ユニットリーダー(組織名称変更) 2018年4月 理化学研究所脳神経科学研究センター研究基盤開発部門 副部門長

Research Interests・Research Keywords

  • Research theme:Studies of a molecular cascade that links nutritional environment to neuronal disease risk

    Keyword:Laboratory animals, Laboratory animal medicine, Animal model, Gut microbiota, Behavior analysis

    Research period: 2021.4

Awards

  • エーザイ科学賞特別賞

    2020.10   エーザイ株式会社   N型カルシウムチャネル遺伝子改変マウスの作成と解析

  • 日本獣医学会賞

    2012.3   日本獣医学会   網羅的マウス表現型解析システムを用いた脳機能研究モデルマウスの開発と記憶のメカニズム解明に関する研究

  • 獣医学奨励賞

    2007.4   日本獣医学会   導入遺伝子産物の時期特異的活性化トランスジェニックマウスを用いたNMDAレセプターNR2BサブユニットとαCaMKIIの結合が学習記憶に与える影響

  • 日本獣医学会第143回学術集会大会長賞

    2007.3   日本獣医学会  

  • 日本実験動物医学会前島賞

    2007.3   日本実験動物医学会  

  • AFLAS-ICLAS Young Investigator Award

    2006.8   Asian Federation of Laboratory Animal Science Associations  

  • 日本実験動物学会奨励賞

    2006.5   日本実験動物学会   遺伝子組換え動物を用いた電位依存性カルシウムチャネルの解析

  • エーザイ科学賞特別賞

    2000.8   エーザイ株式会社  

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Papers

  • Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature

    Nishimura H., Elhussiny M.Z., Ouchi Y., Haraguchi S., Itoh T.Q., Gilbert E.R., Cline M.A., Nishimura S., Hosaka Y.Z., Takahashi E., Cockrem J.F., Bungo T., Chowdhury V.S.

    Neuropeptides   107   102459   2024.10   ISSN:01434179

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    High ambient temperatures (HT) can increase diencephalic neuropeptide Y (NPY) expression, and central injection of NPY attenuates heat stress responses while inducing an antioxidative state in the chick spleen. However, there is a lack of knowledge about NPY receptor expression, and its regulation by HT, in the chick spleen. In the current study, male chicks were used to measure the expression of NPY receptors in the spleen and other immune organs under acute (30 vs. 40 ± 1°C for 3 h) or chronic (30 vs. 40 ± 1°C for 3 h/day for 3 days) exposure to HT and in response to central injection of NPY (47 pmol, 188 pmol, or 1 nmol). We found that NPY-Y4 receptor mRNA was expressed in the spleen, but not in other immune organs studied. Immunofluorescence staining revealed that NPY-Y4 receptors were localized in the splenic pulp. Furthermore, NPY-Y4 receptor mRNA increased in the chick spleen under both acute and chronic exposure to HT. Central NPY at two dose levels (47 and 188 pmol) and a higher dose (1 nmol) did not increase splenic NPY-Y4 receptor mRNA expression or splenic epinephrine under HT (35 ± 1°C), and significantly increased 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations under HT (40 ± 1°C). In conclusion, increased expression of NPY-Y4 receptor mRNA in the spleen under HT suggest that Y4 receptor may play physiological roles in response to HT in male chicks.

    DOI: 10.1016/j.npep.2024.102459

    Scopus

    PubMed

  • Characteristics of Common Marmoset

    TAKAHASHI Eiki

    Fukuoka Acta Medica   114 ( 3 )   109 - 115   2023.9   ISSN:0016254X

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    Language:Japanese  

    Rodent laboratory animals, such as mice and rats, have greatly contributed to biomedical research. While their usefulness will remain unchanged in the future, nonhuman primates also provide excellent models for research to examine disease mechanisms and to assess the safety and efficacy of developing novel therapeutic approaches because of their genetic, metabolic, and physiological similarities to humans. Among nonhuman primates, the common marmoset (Callithrix jacchus) is a suitable laboratory animal. The common marmoset has several advantages compared to macaque species, including a smaller body size, availability, easy breeding in captivity, low husbandry costs, fewer zoonotic issues, early sexual maturation, and a short gestation period, indicating that the common marmoset may represent an alternative species to traditional nonhuman primates such as Cynomolgus macaque, Rhesus macaque, and Japanese macaque. In addition, the development of transgenic marmosets has become possible. This article provides an overview of the ecology, husbandry, and characteristics of the common marmoset.

    CiNii Research

  • Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing Reviewed International journal

    XiangYu Yang, YaFei Mao, Xuan-Kai Wang, Dong-Ni Ma, Zhen Xu, Neng Gong, Barbara Henning, Xu Zhang, Guang He, Yong-Yong Shi, Evan E Eichler, Zhi-Qiang Li, Eiki Takahashi, Wei-Dong Li

    Zool Res   44 ( 5 )   837 - 847   2023.9

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    DOI: 10.24272/j.issn.2095-8137.2022.514

  • Decomposing Working Memory in Recurrent Major Depression: Impaired Encoding and Limited Maintenance Immune-to-Encoding Constraint Reviewed International journal

    Zhitang Chen, Zheng Dou, Hui Xu, Zhenghua Wang , Suhua Zeng, Xiangyu Yang, @Eiki Takahashi, Milos R Popovic, Lihui Wang, Weidong Li

    Brain Sci   13 ( 1 )   38   2022.12

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    DOI: 10.3390/brainsci13010038

  • Pathogenicity of Bordetella bronchiseptica isolated from apparently healthy rabbits in guinea pig, rat, and mouse Reviewed International journal

    Kameyama H, Fujimoto Y, Tomioka Y, Yamamoto S, Suyama H, Inoue H, Takahashi E, Ono E.

    J Vet Med Sci.   84 ( 4 )   574 - 581   2022.4

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    DOI: 10.1292/jvms.21-0494.

  • A natural marmoset model of genetic generalized epilepsy. Reviewed International journal

    Yang X, Chen Z, Wang Z, He G, Li Z, Shi Y, Gong N, Zhao B, Kuang Y, Takahashi E, Li W.

    Mol Brain.   15 ( 1 )   16   2022.2

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    DOI: doi: 10.1186/s13041-022-00901-2.

  • Differential effects of different diets on depressive-like phenotypes in C57BL/JJmsSLc mice

    Eiki Takahashi, Etsuro Ono

    Physiology & Behavior   243   113623 - 113623   2022.1

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    DOI: 10.1016/j.physbeh.2021.113623

  • Effects of semi-purified diet on depressive behaviors in aged mice

    Eiki Takahashi, Etsuro Ono

    Biochemistry and Biophysics Reports   28   101152 - 101152   2021.12

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    DOI: 10.1016/j.bbrep.2021.101152

  • Reduced differentiation of intestinal epithelial cells in wasting marmoset syndrome.

    Kimie Niimi, Eiki Takahashi

    The Journal of veterinary medical science   83 ( 5 )   784 - 792   2021.5

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    DOI: 10.1292/jvms.20-0532

  • Simultaneous Fluorescent Identification of Odontoblasts and Ameloblasts. International journal

    K Isono, E Takahashi, I Miyoshi, M Tsuneto, M Hikosaka-Kuniishi, T Yamane, H Yamazaki

    Journal of dental research   100 ( 5 )   532 - 541   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034520974576

  • Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm. International journal

    Mayuko Hashimoto, Shunsuke Kimura, Chihiro Kanno, Yojiro Yanagawa, Takafumi Watanabe, Jun Okabe, Eiki Takahashi, Masashi Nagano, Hiroshi Kitamura

    Cellular and molecular life sciences : CMLS   78 ( 6 )   2929 - 2948   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00018-020-03683-9

  • Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice. International journal

    Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He, Weidong Li

    Molecular brain   13 ( 1 )   162 - 162   2020.11

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    DOI: 10.1186/s13041-020-00703-4

  • CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage. International journal

    Kazuki Kodama, Hiroaki Takahashi, Nobuyasu Oiji, Kenta Nakano, Tadashi Okamura, Kimie Niimi, Eiki Takahashi, Long Guo, Shiro Ikegawa, Tatsuya Furuichi

    FEBS open bio   10 ( 6 )   1096 - 1103   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2211-5463.12859

  • Kainic acid-induced seizures in the common marmoset. International journal

    Akiyoshi Ishikawa, Yuri Mizuno, Keita Sakai, Takehiro Maki, Ryo Tanaka, Yasuhiro Oda, Kimie Niimi, Eiki Takahashi

    Biochemical and biophysical research communications   525 ( 3 )   595 - 599   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2020.02.121

  • Simplified drug efficacy screening system for sleep-disorder drugs using non-human primates. International journal

    Keita Sakai, Akiyoshi Ishikawa, Yuri Mizuno, Takehiro Maki, Yasuhiro Oda, Eiki Takahashi

    Heliyon   6 ( 3 )   e03524   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.heliyon.2020.e03524

  • Comparison of the fecal microbiota of two monogastric herbivorous and five omnivorous mammals

    Rana Kobayashi, Kentaro Nagaoka, Naomichi Nishimura, Satoshi Koike, Eiki Takahashi, Kimie Niimi, Harutaka Murase, Teruo Kinjo, Takamitsu Tsukahara, Ryo Inoue

    Animal Science Journal   91 ( 1 )   2020.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/asj.13366

  • ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration. International journal

    Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi, Koji Yamanaka

    Molecular brain   13 ( 1 )   8 - 8   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-0550-4

  • New system to examine the activity and water and food intake of germ-free mice in a sealed positive-pressure cage. International journal

    Kimie Niimi, Eiki Takahashi

    Heliyon   5 ( 8 )   e02176   2019.8

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    DOI: 10.1016/j.heliyon.2019.e02176

  • Measurement of the α1-proteinase inhibitor (α1-antitrypsin) of common marmoset and intestinal protein loss in wasting syndrome. International journal

    39 ( 7 )   2019.7

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    Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in WMS must be understood. In the present study, we investigated whether intestinal protein loss, a known reason for hypoalbuminemia, occurs in this disease. Fecal α1-proteinase inhibitor (α1-PI, also known as α1-antitrypsin) has been used to diagnose intestinal protein loss in other species. To develop an assay system for this protein, marmoset α1-PI was purified from plasma and antibodies against it were developed using the purified protein. Using the antibodies, a sandwich enzyme-linked immunosorbent assay (ELISA) to measure marmoset α1-PI was developed, and its detection sensitivity for fecal samples was ∼20-fold higher than that of a commercial kit for human α1-PI. From this ELISA, the reference intervals for serum and feces of healthy marmosets were 0.87-1.85 mg/ml and 0.53-395.58 μg/g, respectively. The average concentrations of α1-PI in serum and feces of seven WMS-affected marmosets were 1.17 mg/ml and 1357.58 μg/g, respectively. Although there were no significant differences in the serum concentrations between healthy and WMS-affected marmosets, the fecal concentrations were significantly higher in WMS-affected marmosets than in healthy individuals, suggesting that intestinal protein loss occurs in WMS. Intestinal protein loss of WMS-affected marmosets was significantly attenuated with treatment, suggesting that it is one of the mechanisms involved in the hypoalbuminemia observed in WMS.

    DOI: 10.1042/BSR20190562

  • Rearing and breeding of germ-free mice for over 1 year in a sealed positive pressure cage system.

    Niimi K, Hardy P, Bilecki B, Takahashi E

    Jpn J Vet Res   67 ( 1 )   119 - 125   2019.2

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  • End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules. International journal

    ACS nano   13 ( 1 )   305 - 312   2019.1

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    DOI: 10.1021/acsnano.8b06189

  • Comparison of gut microbiota composition between laboratory-bred marmosets (Callithrix jacchus) with chronic diarrhea and healthy animals using terminal restriction fragment length polymorphism analysis. International journal

    Yuko Shigeno, Mutsumi Toyama, Mutsumi Nakamura, Kimie Niimi, Eiki Takahashi, Yoshimi Benno

    Microbiology and immunology   62 ( 11 )   702 - 710   2018.11

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    DOI: 10.1111/1348-0421.12655

  • Sentinel EAD program can detect more microorganisms than sentinel animals.

    Niimi K, Maruyama S, Sako N, Miyata K, Yoshimoto T, Bilecki B, Henderson KS, Takahashi E

    Jpn J Vet Res   66 ( 2 )   125 - 129   2018.5

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  • Generation and validation of novel anti-bovine CD163 monoclonal antibodies ABM-1A9 and ABM-2D6. International journal

    Yoshinori Shimamoto, Junko Nio-Kobayashi, Hiroshi Watarai, Masashi Nagano, Natsuko Saito, Eiki Takahashi, Hidetoshi Higuchi, Atsushi Kobayashi, Takashi Kimura, Hiroshi Kitamura

    Veterinary immunology and immunopathology   198   6 - 13   2018.4

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    DOI: 10.1016/j.vetimm.2018.02.004

  • Larger cages with housing unit environment enrichment improve the welfare of marmosets.

    Takuro Yoshimoto, Eiki Takahashi, Shunji Yamashita, Kiichi Ohara, Kimie Niimi

    Experimental animals   67 ( 1 )   31 - 39   2018.2

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    DOI: 10.1538/expanim.17-0058

  • Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. International journal

    Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Chen

    Nature communications   9 ( 1 )   114 - 114   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-017-02531-y

  • Correction: Functional significance of rare neuroligin 1 variants found in autism. International journal

    PLoS genetics   13 ( 10 )   e1007035   2017.10

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    DOI: 10.1371/journal.pgen.1007035

  • Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes

    M Maekawa, A Watanabe, Y Iwayama, T Kimura, K Hamazaki, S Balan, H Ohba, Y Hisano, Y Nozaki, T Ohnishi, M Toyoshima, C Shimamoto, K Iwamoto, M Bundo, N Osumi, E Takahashi, A Takashima, T Yoshikawa

    Translational Psychiatry   7 ( 9 )   e1229 - e1229   2017.9

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    DOI: 10.1038/tp.2017.182

  • Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells. International journal

    Hiroshi Kitamura, Takeshi Ishino, Yoshinori Shimamoto, Jun Okabe, Tomomi Miyamoto, Eiki Takahashi, Ichiro Miyoshi

    Mediators of inflammation   2017   6909415 - 6909415   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2017/6909415

  • Functional significance of rare neuroligin 1 variants found in autism. International journal

    PLoS genetics   13 ( 8 )   e1006940   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pgen.1006940

  • Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice. International journal

    Natsuko Saito, Shunsuke Kimura, Tomomi Miyamoto, Sanae Fukushima, Misato Amagasa, Yoshinori Shimamoto, Chieko Nishioka, Shiki Okamoto, Chitoku Toda, Kohei Washio, Atsushi Asano, Ichiro Miyoshi, Eiki Takahashi, Hiroshi Kitamura

    Biochemistry and biophysics reports   9   322 - 329   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrep.2017.01.009

  • Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. International journal

    1655   138 - 144   2017.1

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    Voltage-gated Ca2+ channels (VGCCs) are comprised of α1, α2/δ, β, and γ subunits. The pore-forming α1 subunit is essential for the proper functioning of Ca2+ channels, while the α2/δ subunit interacts with components of the extracellular matrix. The α2/δ subunit is related in many neuropathological symptoms, including epilepsy and cerebellar ataxia. We previously reported that the mutant Cav.2.1α1 subunit has protective effects following brain injury. The present study aimed to investigate the effects of the α2/δ subunit inhibition alone and in combination with the inhibition of the Cav.2.1α1 subunit following brain injury by injecting Gabapentin using Cav.2.1α1 mutant heterozygous rolling Nagoya (rol/+) and wild-type (+/+) mice. Gabapentin binds to the α2/δ subunit and leads to Ca2+ flow disturbance. A cryogenic method was used to induce brain injury. The mice pretreated with 100mg/kg Gabapentin exhibited a decrease in lesion size, while the 40mg/kg Gabapentin injection was effective in rol/+ mice but not +/+ mice. The administration of 100mg/kg Gabapentin also attenuated reactive astrocyte activity and neuronal degeneration; the pattern of results was similar to that for lesion size. An analysis of phosphorylated p38 (pp38) expression revealed that Gabapentin suppressed the p38 mitogen-activated protein kinase (MAPK) signaling cascade by interrupting glutamate-signaling induced by the inhibition of VGCCs. The present findings demonstrated that the administration of the α2/δ subunit inhibitor, Gabapentin, had neuroprotective effects following brain injury.

    DOI: 10.1016/j.brainres.2016.11.009

  • Investigation of sleep-wake rhythm in non-human primates without restraint during data collection.

    Akiyoshi Ishikawa, Keita Sakai, Takehiro Maki, Yuri Mizuno, Kimie Niimi, Yasuhiro Oda, Eiki Takahashi

    Experimental animals   66 ( 1 )   51 - 60   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.16-0073

  • Tranexamic Acid and Supportive Measures to Treat Wasting Marmoset Syndrome. International journal

    Takuro Yoshimoto, Kimie Niimi, Eiki Takahashi

    Comparative medicine   66 ( 6 )   468 - 473   2016.12

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  • In situ hybridization study of CYP2D mRNA in the common marmoset brain.

    Yoshinori Shimamoto, Kimie Niimi, Hiroshi Kitamura, Sae Tsubakishita, Eiki Takahashi

    Experimental animals   65 ( 4 )   465 - 471   2016.11

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  • Perinatal Iron Deficiency-Induced Hypothyroxinemia Impairs Early Brain Development Regardless of Normal Iron Levels in the Neonatal Brain

    Xiaona Hu, Ranran Wang, Zhongyan Shan, Yujie Dong, Hongzhi Zheng, Forrest Fabian Jesse, Elizabeth Rao, Eiki Takahashi, Weidong Li, Weiping Teng, Xiaochun Teng

    Thyroid   26 ( 7 )   891 - 900   2016.7

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    DOI: 10.1089/thy.2015.0293

  • Protein expression pattern in cerebellum of Cav2.1 mutant, tottering-6j mice.

    Tae Yeon Kim, Kimie Niimi, Eiki Takahashi

    Experimental animals   65 ( 3 )   207 - 14   2016.7

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    DOI: 10.1538/expanim.15-0120

  • Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome.

    Takuro Yoshimoto, Kimie Niimi, Eiki Takahashi

    The Journal of veterinary medical science   78 ( 5 )   837 - 43   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1292/jvms.15-0675

  • Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury. International journal

    T Y Kim, T Yoshimoto, Y Aoyama, K Niimi, E Takahashi

    Neuroscience   313   110 - 21   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroscience.2015.11.035

  • Absence-like seizures and their pharmacological profile in tottering-6j mice

    Tae Yeon Kim, Takehiro Maki, Ying Zhou, Keita Sakai, Yuri Mizuno, Akiyoshi Ishikawa, Ryo Tanaka, Kimie Niimi, Weidong Li, Norihiro Nagano, Eiki Takahashi

    Biochemical and Biophysical Research Communications   463 ( 1-2 )   148 - 153   2015.7

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    DOI: 10.1016/j.bbrc.2015.05.050

  • The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness. International journal

    Yue Zhou, Hongli Mao, Binata Joddar, Nobuhisa Umeki, Yasushi Sako, Ken-Ichi Wada, Chieko Nishioka, Eiki Takahashi, Yi Wang, Yoshihiro Ito

    Scientific reports   5   11386 - 11386   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep11386

  • Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel. International journal

    461 ( 2 )   200 - 5   2015.5

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    Genetic analyses have revealed an important association between P/Q-type calcium channel activities and hereditary neurological disorders. The P/Q-type channels are composed principally of heterologous multimeric subunits including CaV2.1 and CaVβ4. Of these, the β4 subunit is thought to play a significant role in channel physiology, because a mouse line mutant in that subunit (the lethargic mouse: lh) exhibits a severe ataxic phenotype. The aim of the present study was to elucidate the physiological importance of the β4 subunit. ECG analysis showed that the T wave was high in 8-week-old lh mutants; this may be associated with hyperkalemia. Upon pharmacological ECG analysis, 2-3-week-old lh mutants exhibited reduced responses to a β-blocker and a muscarinic receptor antagonist. Analysis of heart rate variability revealed that the R-R interval was unstable in lh mutants and that both the low- and high-frequency components had increased in extent, indicating that the tonus of both the sympathetic and parasympathetic nervous systems was modified. Thus, our present study revealed that the β4 subunit played a significant role in regulation of sympathetic and parasympathetic nerve activities.

    DOI: 10.1016/j.bbrc.2015.03.112

  • Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling. International journal

    Siyoong Seo, Kazumitsu Onizuka, Chieko Nishioka, Eiki Takahashi, Satoshi Tsuneda, Hiroshi Abe, Yoshihiro Ito

    Organic & biomolecular chemistry   13 ( 15 )   4589 - 95   2015.4

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    DOI: 10.1039/c5ob00199d

  • Congenital malformation of the vaginal orifice, imperforate vagina, in the common marmoset (Callithrix jacchus).

    Kimie Niimi, Ayaka Oguchi, Kenji Nishio, Yasushi Okano, Eiki Takahashi

    The Journal of veterinary medical science   77 ( 3 )   345 - 8   2015.3

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    DOI: 10.1292/jvms.14-0378

  • Piebald mutation on a C57BL/6J background.

    Sanae Fukushima, Kimie Niimi, Eiki Takahashi

    The Journal of veterinary medical science   77 ( 2 )   161 - 6   2015.2

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    DOI: 10.1292/jvms.14-0408

  • Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture

    Binata Joddar, Chieko Nishioka, Eiki Takahashi, Yoshihiro Ito

    Journal of Materials Chemistry B   3 ( 11 )   2301 - 2307   2015.2

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    DOI: 10.1039/c4tb01635a

  • Japan's RIKEN BSI: Whole Facility Chlorine Dioxide Gas Decontamination Approach for a Barrier Facility—A Case Study

    19 ( 4 )   201 - 210   2014.12

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    DOI: 10.1177/153567601401900404

  • The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. International journal

    Shinichi Nakagawa, Masayuki Shimada, Kaori Yanaka, Mari Mito, Takashi Arai, Eiki Takahashi, Youko Fujita, Toshihiko Fujimori, Laura Standaert, Jean-Christophe Marine, Tetsuro Hirose

    Development (Cambridge, England)   141 ( 23 )   4618 - 27   2014.12

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    DOI: 10.1242/dev.110544

  • Age-dependent kainate sensitivity in heterozygous rolling Nagoya Cav2.1 channel mutant mice. International journal

    Tae Yeon Kim, Takuro Yoshimoto, Yo Aoyama, Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Pharmacology, biochemistry, and behavior   124   250 - 9   2014.9

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    DOI: 10.1016/j.pbb.2014.06.022

  • Rolling Nagoya mouse strain (PROD-rol/rol) with classic piebald mutation.

    Takuro Yoshimoto, Yo Aoyama, Tae Yeon Kim, Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    The Journal of veterinary medical science   76 ( 8 )   1093 - 8   2014.8

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  • Differences in saccharin preference and genetic alterations of the Tas1r3 gene among senescence-accelerated mouse strains and their parental AKR/J strain. International journal

    Kimie Niimi, Eiki Takahashi

    Physiology & behavior   130   108 - 12   2014.5

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    DOI: 10.1016/j.physbeh.2014.04.005

  • Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. International journal

    Kimie Niimi, Yanfei Han, Ying Zhou, Takuro Yoshimoto, Fu Dai, Xiaochun Teng, Xiaoli Tian, Weidong Li, Eiki Takahashi

    Behavioural brain research   259   45 - 9   2014.2

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    DOI: 10.1016/j.bbr.2013.10.033

  • Detection of calprotectin and apoptotic activity in the colon of marmosets with chronic diarrhea.

    Erika Nakashima, Yasushi Okano, Kimie Niimi, Eiki Takahashi

    The Journal of veterinary medical science   75 ( 12 )   1633 - 6   2013.12

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  • Selection of suitable reference genes for mRNA quantification studies using common marmoset tissues. International journal

    Yoshinori Shimamoto, Hiroshi Kitamura, Kimie Niimi, Yasunaga Yoshikawa, Fumio Hoshi, Mayumi Ishizuka, Eiki Takahashi

    Molecular biology reports   40 ( 12 )   6747 - 55   2013.12

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    DOI: 10.1007/s11033-013-2791-0

  • Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators. International journal

    Asako Sakaue-Sawano, Tetsushi Hoshida, Masahiro Yo, Reiko Takahashi, Kenji Ohtawa, Takashi Arai, Eiki Takahashi, Shinichi Noda, Hiroyuki Miyoshi, Atsushi Miyawaki

    Development (Cambridge, England)   140 ( 22 )   4624 - 32   2013.11

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    DOI: 10.1242/dev.099226

  • Improvement of spontaneous alternation behavior deficit by activation of α4β2 nicotinic acetylcholine receptor signaling in the ganglioside GM3-deficient mice.

    34 ( 4 )   189 - 95   2013.8

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    We have reported that in ganglioside GM3-deficient (GM3(-/-)) mice, spontaneous alternation behavior assessed by a Y-maze task was significantly lower, and total arm entries were significantly higher than in wild-type mice. The objective of the present study was to examine the role of nicotinic acetylcholine receptor (nAChR) signaling in impairment of spontaneous alternation behavior of GM3(-/-) mice. Nicotine treatment (0.3, 1.0 mg/kg, s.c.) dose dependently improved the spontaneous alternation deficit without affecting total arm entries in GM3(-/-) mice. The nicotine-induced (1.0 mg/kg, s.c.) improvement was significantly abolished by the nAChR antagonist mecamylamine (1.0 mg/kg, i.p.). The α4β2 nAChR antagonist dihydro-β-erythroidine (2.5, 10.0 mg/kg, i.p.) dose dependently counteracted the nicotine-induced improvement of spontaneous alternation in GM3(-/-) mice, whereas the α7 nAChR antagonist methyllycaconitine (2.5, 10.0 mg/kg, i.p.) did not. In addition, the α4β2 nAChR agonist RJR-2403 (5.0, 10.0 mg/kg, s.c.) dose dependently and significantly improved the spontaneous alternation deficit, whereas the α7 nAChR agonist PNU120596 (0.3, 1.0, 3.0 mg/kg, i.p.) did not. These findings revealed that nicotine improved spontaneous alternation behavior of GM3(-/-) mice via the activation of α4β2, but not α7, nAChR. Thus, the ganglioside GM3 might be responsible for α4β2 nAChR signaling in the spontaneous alternation behavior.

  • Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis

    Chihiro Miyamoto Nakazawa, Kohdoh Shikata, Mai Uesugi, Hiroyuki Katayama, Ken Aoshima, Kazuhiro Tahara, Eiki Takahashi, Takayuki Hida, Hisashi Shibata, Hiroo Ogura, Takashi Seiki, Yoshiya Oda, Junro Kuromitsu, Norimasa Miyamoto

    Journal of Receptors and Signal Transduction   33 ( 4 )   224 - 233   2013.8

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    DOI: 10.3109/10799893.2012.756895

  • Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1). International journal

    Yo Aoyama, Tae Yeon Kim, Takuro Yoshimoto, Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Brain research   1515   48 - 54   2013.6

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    DOI: 10.1016/j.brainres.2013.03.053

  • Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice. International journal

    434 ( 1 )   60 - 4   2013.4

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    One of the main instigators leading to cell death and brain damage following ischemia is Ca(2+) dysregulation. Neuronal membrane depolarization results in the activation of voltage-gated Ca(2+) (CaV) channels and intracellular Ca(2+) influx. We investigated the physiological role of the CaV2.1 (P/Q-type) channel in ischemic neuronal injury using CaV2.1 channel α1 subunit mutant mice, rolling Nagoya and leaner mice. The in vivo ischemia model with a complete occlusion of the middle cerebral artery showed that the infarct area at 24h was significantly smaller in rolling Nagoya (27.1±3.5% of total brain volume) and leaner (20.1±3.5%) mice compared to wild-type (42.9±4.5%) mice. In an in vitro Ca(2+) imaging study, oxygen-glucose deprivation using a hippocampal slice induced a significantly slower rate of increase in intracellular Ca(2+) concentration ([Ca(2+)]i) in rolling Nagoya (0.083±0.007/min) and leaner (0.062±0.006/min) mice compared to wild-type (0.105±0.008/min) mice. These results demonstrate that the mutant CaV2.1 channel in rolling Nagoya and leaner mice plays a different protective role in a ([Ca(2+)]i)-dependent manner in ischemic models and indicate that CaV2.1 channel blockers may be used preventively against ischemic injury.

    DOI: 10.1016/j.bbrc.2013.03.066

  • New Ataxic Tottering-6j Mouse Allele Containing a Cacna1a Gene Mutation

    Weidong Li, Ying Zhou, Xiaoli Tian, Tae Yeon Kim, Namiko Ito, Kaori Watanabe, Akiko Tsuji, Kimie Niimi, Yo Aoyama, Takashi Arai, Eiki Takahashi

    PLoS ONE   7 ( 8 )   e44230 - e44230   2012.8

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    DOI: 10.1371/journal.pone.0044230

  • Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. International journal

    Nao Fukumoto, Naoki Kitamura, Kimie Niimi, Eiki Takahashi, Chitoshi Itakura, Izumi Shibuya

    Neuroscience research   73 ( 3 )   199 - 206   2012.7

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    DOI: 10.1016/j.neures.2012.04.006

  • Comparative anatomy of marmoset and mouse cortex from genomic expression. International journal

    Hiromi Mashiko, Aya C Yoshida, Satomi S Kikuchi, Kimie Niimi, Eiki Takahashi, Jun Aruga, Hideyuki Okano, Tomomi Shimogori

    The Journal of neuroscience : the official journal of the Society for Neuroscience   32 ( 15 )   5039 - 53   2012.4

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    DOI: 10.1523/JNEUROSCI.4788-11.2012

  • Feeder Cells Support the Culture of Induced Pluripotent Stem Cells Even after Chemical Fixation

    Xiao-Shan Yue, Masako Fujishiro, Chieko Nishioka, Takashi Arai, Eiki Takahashi, Jian-Sheng Gong, Toshihiro Akaike, Yoshihiro Ito

    PLoS ONE   7 ( 3 )   e32707 - e32707   2012.3

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    DOI: 10.1371/journal.pone.0032707

  • Role of Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Behavioural brain research   218 ( 2 )   353 - 6   2011.4

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    DOI: 10.1016/j.bbr.2010.12.019

  • Emotional behavior in heterozygous rolling mouse Nagoya Ca v 2.1 channel mutant mice. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Neurobiology of aging   32 ( 3 )   486 - 96   2011.3

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    DOI: 10.1016/j.neurobiolaging.2009.03.001

  • Impairment of neuropsychological behaviors in ganglioside GM3-knockout mice. International journal

    Kimie Niimi, Chieko Nishioka, Tomomi Miyamoto, Eiki Takahashi, Ichiro Miyoshi, Chitoshi Itakura, Tadashi Yamashita

    Biochemical and biophysical research communications   406 ( 4 )   524 - 8   2011.3

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    DOI: 10.1016/j.bbrc.2011.02.071

  • Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the Ca V 2.1 alpha1 mutation. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Behavioural brain research   213 ( 1 )   121 - 5   2010.11

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    DOI: 10.1016/j.bbr.2010.04.030

  • Subthreshold pharmacological and genetic approaches to analyzing CaV2.1-mediated NMDA receptor signaling in short-term memory. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    European journal of pharmacology   645 ( 1-3 )   113 - 8   2010.10

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    DOI: 10.1016/j.ejphar.2010.07.029

  • Levetiracetam-mediated emotional behavior in heterozygous rolling Nagoya Ca(V)2.1 channel mutant mice. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Pharmacology, biochemistry, and behavior   96 ( 3 )   294 - 300   2010.9

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    DOI: 10.1016/j.pbb.2010.05.020

  • Hallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Senescence-Accelerated Mice

    Kimie NIIMI, Eiki TAKAHASHI, Chitoshi ITAKURA

    Experimental Animals   59 ( 4 )   441 - 447   2010.7

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    DOI: 10.1538/expanim.59.441

  • Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Journal of molecular neuroscience : MN   41 ( 2 )   223 - 9   2010.6

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    DOI: 10.1007/s12031-009-9216-5

  • Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit. International journal

    Osamu Nakagawasai, Hiroshi Onogi, Satoru Mitazaki, Atsushi Sato, Kenya Watanabe, Hiroko Saito, Shigeo Murai, Kota Nakaya, Manabu Murakami, Eiki Takahashi, Koichi Tan-No, Takeshi Tadano

    Behavioural brain research   208 ( 1 )   224 - 30   2010.3

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    DOI: 10.1016/j.bbr.2009.11.042

  • Neonatal motor functions in Cacna1a-mutant rolling Nagoya mice. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Behavioural brain research   207 ( 2 )   273 - 9   2010.3

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    DOI: 10.1016/j.bbr.2009.10.017

  • Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Behavioural brain research   204 ( 1 )   241 - 5   2009.12

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    DOI: 10.1016/j.bbr.2009.05.020

  • Adiposity-related biochemical phenotype in senescence-accelerated mouse prone 6 (SAMP6). International journal

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Comparative medicine   59 ( 5 )   431 - 6   2009.10

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  • Combination of modified SHIRPA and pharmacological approach uncovers neuronal alteration in senescence-accelerated mouse prone 6 (SAMP6) strain. International journal

    Kimie Niimi, Eiki Takahashi

    Neuroscience letters   458 ( 2 )   53 - 6   2009.7

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    DOI: 10.1016/j.neulet.2009.04.042

  • Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Brain research   1279   50 - 7   2009.7

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    DOI: 10.1016/j.brainres.2009.05.016

  • Enhanced CaMKII activity and spatial cognitive function in SAMP6 mice. International journal

    Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

    Behavioral neuroscience   123 ( 3 )   527 - 32   2009.6

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    DOI: 10.1037/a0015119

  • Modulators of voltage-dependent calcium channels for the treatment of nervous system diseases. International journal

    Eiki Takahashi, Kimie Niimi

    Recent patents on CNS drug discovery   4 ( 2 )   96 - 111   2009.6

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  • Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. International journal

    Eiki Takahashi, Kimie Niimi

    Experimental gerontology   44 ( 4 )   274 - 9   2009.4

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    DOI: 10.1016/j.exger.2008.11.006

  • Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya

    N. Fukumoto, Y. Obama, N. Kitamura, K. Niimi, E. Takahashi, C. Itakura, I. Shibuya

    Neuroscience   160 ( 1 )   165 - 173   2009.4

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    DOI: 10.1016/j.neuroscience.2009.02.032

  • Analysis of motor function and dopamine systems of SAMP6 mouse. International journal

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Physiology & behavior   96 ( 3 )   464 - 9   2009.3

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    DOI: 10.1016/j.physbeh.2008.11.012

  • Modified autonomic regulation in mice with a P/Q-type calcium channel mutation. International journal

    Takayoshi Ohba, Eiki Takahashi, Manabu Murakami

    Biochemical and biophysical research communications   381 ( 1 )   27 - 32   2009.3

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    DOI: 10.1016/j.bbrc.2009.01.184

  • The utilization of gene targeting models during in preclinical study of drug discovery process--example of phenotypic and functional analysis of Cacna1beta gene product. International journal

    Norimasa Miyamoto, Kana Namiki, Naoki Tokuhara, Mai Uesugi, Eiki Takahashi, Junro Kuromitsu, Yoshitoshi Kasuya

    Current pharmaceutical biotechnology   10 ( 2 )   261 - 7   2009.2

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  • Age dependence of motor activity and sensitivity to dopamine receptor 1 agonist, SKF82958, of inbred AKR/J, BALB/c, C57BL/6J, SAMR1, and SAMP6 strains. International journal

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Brain research   1250   175 - 82   2009.1

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    DOI: 10.1016/j.brainres.2008.10.043

  • Age-related difference in nociceptive behavior between SAMP6 and SAMR1 strains. International journal

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Neuroscience letters   444 ( 1 )   60 - 3   2008.10

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    DOI: 10.1016/j.neulet.2008.08.003

  • Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6. International journal

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Experimental gerontology   43 ( 9 )   847 - 52   2008.9

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    DOI: 10.1016/j.exger.2008.06.010

  • Modified Sympathetic Nerve System Activity with Overexpression of the Voltage-dependent Calcium Channel β3 Subunit

    283 ( 36 )   24554 - 24560   2008.9

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    DOI: 10.1074/jbc.m802319200

  • Additive subthreshold dose effects of cannabinoid CB1 receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests

    Eiki Takahashi, Mariko Katayama, Kimie Niimi, Chitoshi Itakura

    European Journal of Pharmacology   589 ( 1-3 )   149 - 156   2008.7

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    DOI: 10.1016/j.ejphar.2008.05.020

  • Emotional behavior and expression patterns of tyrosine hydroxylase and tryptophan hydroxylase in senescence-accelerated mouse (SAM) P6 mice

    Kimie Niimi, Eiki Takahashi, Chitoshi Itakura

    Behavioural Brain Research   188 ( 2 )   329 - 336   2008.4

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    DOI: 10.1016/j.bbr.2007.11.014

  • C57BL/6JとC57BL/6Nマウスの隔離飼育ストレスによる空間的記憶への影響

    高橋英機

    実験動物技術   42   9 - 16   2007.12

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  • Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning

    Y. Zhou, E. Takahashi, W. Li, A. Halt, B. Wiltgen, D. Ehninger, G.-D. Li, J. W. Hell, M. B. Kennedy, A. J. Silva

    Journal of Neuroscience   27 ( 50 )   13843 - 13853   2007.12

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    DOI: 10.1523/jneurosci.4486-07.2007

  • Modified sympathetic regulation in N-type calcium channel null-mouse. International journal

    Manabu Murakami, Takayoshi Ohba, Tsai-Wen Wu, Susumu Fujisawa, Takashi Suzuki, Yoichiro Takahashi, Eiki Takahashi, Hiroyuki Watanabe, Ichiro Miyoshi, Kyoichi Ono, Hironobu Sasano, Hiroshi Ito, Toshihiko Iijima

    Biochemical and biophysical research communications   354 ( 4 )   1016 - 20   2007.3

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  • Deficits in spatial learning and motor coordination in ADAM11-deficient mice

    Eiki Takahashi, Koji Sagane, Tohru Oki, Kazuto Yamazaki, Takeshi Nagasu, Junro Kuromitsu

    BMC Neuroscience   7 ( 1 )   2006.12

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    DOI: 10.1186/1471-2202-7-19

  • Individual and group housing in N-type Ca2+ channel alpha1B subunit-deficient mice differently affect motor activity. International journal

    Eiki Takahashi, Takeshi Nagasu

    Journal of the American Association for Laboratory Animal Science : JAALAS   45 ( 5 )   44 - 7   2006.9

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  • Stability of recent and remote contextual fear memory

    Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ

    Learning & Memory   13 ( 4 )   451 - 457   2006.7

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    DOI: 10.1101/lm.183406

  • Enhanced expression of Ca2+ channel alpha1A and beta4 subunits and phosphorylated tyrosine hydroxylase in the adrenal gland of N-type Ca2+ channel alpha1B subunit-deficient mice with a CBA/JN genetic background. International journal

    Eiki Takahashi, Takeshi Nagasu

    Comparative medicine   56 ( 3 )   168 - 75   2006.6

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  • Altered nociceptive response in ADAM11-deficient mice

    Eiki Takahashi, Koji Sagane, Takeshi Nagasu, Junro Kuromitsu

    Brain Research   1097 ( 1 )   39 - 42   2006.6

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    DOI: 10.1016/j.brainres.2006.04.043

  • Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits of voltage-dependent Ca2+-channels.

    Manabu Murakami, Hitosi Matsui, Takeshi Shiraiwa, Takashi Suzuki, Hironobu Sasano, Eiki Takahashi, Makoto Kashiwayanagi

    Biological & pharmaceutical bulletin   29 ( 3 )   437 - 42   2006.3

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  • Chronic Intracerebroventricular Administration of Relaxin-3 Increases Body Weight in Rats

    TAKAYUKI HIDA, EIKI TAKAHASHI, KODO SHIKATA, TOMOKO HIROHASHI, TORU SAWAI, TAKASHI SEIKI, HIROKAZU TANAKA, TAKATOSHI KAWAI, OSAMU ITO, TORU ARAI, AKIRA YOKOI, TETSUYA HIRAKAWA, HIROO OGURA, TAKESHI NAGASU, NORIMASA MIYAMOTO, JUNRO KUROMITSU

    Journal of Receptors and Signal Transduction   26 ( 3 )   147 - 158   2006.1

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    DOI: 10.1080/10799890600623373

  • 電位依存性カルシウムチャネルα1Bまたはβ3サブユニット欠損マウスの傍糸球体細胞で抑制されたフェロモン応答

    松井等, 白岩剛, 高橋英機, 鈴木貴, 笹野公伸, 村上学, 柏柳誠

    日本味と匂学会誌   12   457 - 458   2005.12

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  • Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice. International journal

    Eiki Takahashi, Masashi Ito, Norimasa Miyamoto, Takeshi Nagasu, Mitsuhiro Ino, Isao Tanaka

    International journal of molecular medicine   15 ( 6 )   937 - 44   2005.6

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  • Genetic Background Influences P/Q-type Ca2+ Channel α1A Subunit mRNA Expression in Olfactory Bulb and Reproductive Ability of N-type Ca2+ Channel α1B Subunit-Deficient Mice

    43 ( 5-6 )   287 - 298   2005.6

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    DOI: 10.1007/s10528-005-5220-9

  • Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. International journal

    Koji Sagane, Kazuhiro Hayakawa, Junko Kai, Tomoko Hirohashi, Eiki Takahashi, Norimasa Miyamoto, Mitsuhiro Ino, Tohru Oki, Kazuto Yamazaki, Takeshi Nagasu

    BMC neuroscience   6   33 - 33   2005.5

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  • Expression pattern of voltage-dependent calcium channel alpha1 and beta subunits in adrenal gland of N-type Ca2+ channel alpha1B subunit gene-deficient mice. International journal

    Eiki Takahashi, Takeshi Nagasu

    Molecular and cellular biochemistry   271 ( 1-2 )   91 - 9   2005.3

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  • Pattern of compensatory expression of voltage-dependent Ca2+ channel alpha1 and beta subunits in brain of N-type Ca2+ channel alpha1B subunit gene-deficient mice with a CBA/JN genetic background.

    Eiki Takahashi, Takeshi Nagasu

    Experimental animals   54 ( 1 )   29 - 36   2005.1

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  • Effect of genetic background on Cav2 channel alpha1 and beta subunit messenger RNA expression in cerebellum of N-type Ca2+ channel alpha1B subunit-deficient mice. International journal

    Eiki Takahashi, Mitsuhiro Ino, Takeshi Nagasu

    Comparative medicine   54 ( 6 )   690 - 4   2004.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice. International journal

    Eiki Takahashi, Mitsuhiro Ino, Norimasa Miyamoto, Takeshi Nagasu

    Neuroscience letters   359 ( 1-2 )   37 - 40   2004.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice. International journal

    Eiki Takahashi, Mitsuhiro Ino, Norimasa Miyamoto, Takeshi Nagasu

    Brain research. Molecular brain research   124 ( 1 )   79 - 87   2004.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Consolidation of CS and US representations in associative fear conditioning

    Paul W. Frankland, Sheena A. Josselyn, Stephan G. Anagnostaras, Jeffrey H. Kogan, Eiki Takahashi, Alcino J. Silva

    Hippocampus   14 ( 5 )   557 - 569   2004.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hipo.10208

  • Analysis of Gene Expression in Peripheral Blood Eosinophils from Patients with Atopic Dermatitis by Differential Display

    Ryoichi Hashida, Kaoru Ogawa, Masami Miyagawa, Yuji Sugita, Eiki Takahashi, Takeshi Nagasu, Toshio Katsunuma, Akira Akasawa, Gozoh Tsujimoto, Kenji Matsumoto, Hirohisa Saito

    131 ( Suppl. 1 )   26 - 33   2003.7

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    Analysis of Gene Expression in Peripheral Blood Eosinophils from Patients with Atopic Dermatitis by Differential Display

    DOI: 10.1159/000070478

  • Differential nociceptive responses in mice lacking the α1B subunit of N-type Ca2+ channels

    12 ( 11 )   2423 - 2427   2001.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00001756-200108080-00027

  • Rescue of a transgenic mouse line by transplantation of a frozen-thawed ovary obtained postmortem

    Takahashi E, Miyoshi I, Nagasu T

    Contemp Top Lab Anim Sci.   40 ( 4 )   28 - 31   2001.7

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  • Functional disorders of the sympathetic nervous system in mice lacking the  1B subunit (Cav 2.2) of N-type calcium channels

    98 ( 9 )   5323 - 5328   2001.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.081089398

  • Restoration of fertility by transplantation of mouse ovary obtained postmortem.

    Takahashi E, Nagasu T

    Contemp Top Lab Anim Sci.   40 ( 1 )   36 - 37   2001.1

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  • Expression analysis of Escherichia coli lacZ reporter gene in transgenic mice

    Eiki Takahashi, Norimasa Miyamoto, Noriko Kajiwara, Keiko Furuya, Keiko Yanai-Taniguchi, Fumihiro Sugiyama, Ken-ichi Yagami

    Brain Research Protocols   5 ( 2 )   159 - 166   2000.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/s1385-299x(00)00009-x

  • Expression analysis of the 5′-upstream region of mouse P/Q-type Ca2+ channel α lA subunit gene fused to Escherichia coli lacZ reporter gene in the spinal cord using transgenic mice

    284 ( 1-2 )   9 - 12   2000.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/s0304-3940(00)00964-2

  • Analysis of the 5'-upstream region of mouse P/Q-type Ca2+ channel alpha1A subunit gene for expression in pancreatic islet beta cells using transgenic mice and HIT-T15 cells

    E Takahashi, N Miyamoto, T Nagasu

    Journal of Molecular Endocrinology   24 ( 2 )   225 - 232   2000.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1677/jme.0.0240225

  • Neuron-specific expression of reporter gene in transgenic mice carrying the 5′-upstream region of mouse P/Q-type Ca2+ channel α1A subunit gene fused to E. coli lacZ reporter gene

    850 ( 1-2 )   47 - 54   1999.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/s0006-8993(99)02077-6

  • Isolation and Functional Characterization of the 5′-Upstream Region of Mouse P/Q-Type Ca2+ Channel α1A Subunit Gene

    260 ( 1 )   54 - 59   1999.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/bbrc.1999.0857

  • Targeted pituitary tumorigenesis using the human thyrotropin β-subunit chain promoter in transgenic mice

    105 ( 2 )   147 - 154   1994.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/0303-7207(94)90164-3

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Books

  • Summary of Currently Available Mouse Models.

    Ito A, Ito N, Niimi, K T Arai T, Takahashi E( Role: Joint author)

    Handbook of in vivo chemistry in mice: From Lab to Living System. Wiley Publishers  2020.4 

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    Language:Others  

  • General Notes of Chemical Administration to Live Animals.

    Ito A, Ito N, Arai T, Takahashi E, Niimi K( Role: Joint author)

    Handbook of in vivo chemistry in mice: From Lab to Living System. Wiley Publishers  2020.4 

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    Language:Others  

  • 細胞・組織染色の達人 : 実験を正しく組む、行う、解釈する免疫染色とISHの鉄板テクニック

    大久保 和央, ジェノスタッフ, 高橋 英機( Role: Supervisor (editorial))

    羊土社  2018.6 

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    Responsible for pages:総ページ数:184, 13p   Language:Japanese  

  • 実験で学ぶ生理学

    獣医生理学・生化学教育懇談会

    学窓社  2014.3 

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    Responsible for pages:総ページ数:xvii, 170p   Language:Japanese  

  • Systemic blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.

    Takahashi E

    Management of Symptoms and Long-Term Neurological Implications. Nova Science Publishers  2013.3 

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    Language:Others  

  • Cav2.1 channelopathy and mouse genetic approaches to investigate function and dysfunction of Cav2.1 channel.

    Takahashi E

    Calcium Signaling. Nova Science Publishers  2012.2 

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    Language:Others  

  • Effect of aging on changes of nociception and Cav2.1 expression pattern in seven inbred mouse strains

    Takahashi E

    Neurological Disorders: New Research. Nova Science Publishers  2012.1 

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    Language:Others  

  • Cav2.1-mediated NMDA receptor signaling in short-term memory

    Takahashi E

    Short-Term Memory: New Research. Nova Science Publishers  2012.1 

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    Language:Others  

  • Physiological role of RTK transactivation in the central nervous system and neuropsychiatric diseases.

    Takahashi E

    Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits. Nova Science Publishers  2012.1 

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  • 実験動物学の原理 : 動物の人道的使用と管理および実験結果の質の向上をめざして

    Zutphen, L. F. M. van, Baumans, Vera, Beynen, Anton C., 笠井, 憲雪, 二宮, 博義, 安居院, 高志, 黒澤, 努

    学窓社  2011.3 

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    Responsible for pages:総ページ数:xv, 373p   Language:Japanese  

  • 現代実験動物学

    笠井, 憲雪, 吉川, 泰弘, 安居院, 高志

    朝倉書店  2009.4 

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    Responsible for pages:総ページ数:219   Language:Japanese  

  • Studies of the Role of Voltage-Dependent Calcium Channels in Nociceptive Neurotransmission in Mice

    Murakami M, Nakagawasai O, Suzuki T, Takahashi E, Takahashi H, Tan-No K, Sasano H, Tadano T, Iijima T( Role: Joint author)

    Trends in Brain Research. Nova Science Publishers  2006.1 

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MISC

  • Digital gene atlas of neonate common marmoset brain.

    Tomomi Shimogori, Ayumi Abe, Yasuhiro Go, Tsutomu Hashikawa, Noriyuki Kishi, Satomi S Kikuchi, Yoshiaki Kita, Kimie Niimi, Hirozumi Nishibe, Misako Okuno, Kanako Saga, Miyano Sakurai, Masae Sato, Tsuna Serizawa, Sachie Suzuki, Eiki Takahashi, Mami Tanaka, Shoji Tatsumoto, Mitsuhiro Toki, Mami U, Yan Wang, Karl J Windak, Haruhiko Yamagishi, Keiko Yamashita, Tomoko Yoda, Aya C Yoshida, Chihiro Yoshida, Takuro Yoshimoto, Hideyuki Okano

    Neuroscience research   2018.3

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    Language:English  

    DOI: 10.1016/j.neures.2017.10.009

  • Characterization of Senescence-Accelerated Mouse Prone 6 (SAMP6) as an Animal Model for Brain Research

    Kimie Niimi, Eiki Takahashi

    Experimental Animals   2014.2

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    Language:Others  

    DOI: 10.1538/expanim.63.1

  • Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory.

    Paul W Frankland, Masuo Ohno, Eiki Takahashi, Adele R Chen, Rui M Costa, Steven A Kushner, Alcino J Silva

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry   2003.4

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    Language:English  

Industrial property rights

Patent   Number of applications: 2   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Japanese Society of Veterinary Science

  • Japanese Association for Laboratory Animal Science

  • Japanese Association for Laboratory Animal Medicine

  • Japanese College of Laboratory Animal Medicine

  • American Association for Laboratory Animal Science

Committee Memberships

  • AAALAC International   Ad hoc consultant   Foreign country

    2020.9 - Present   

  • Executive   Domestic

    2020.5 - 2024.6   

  • 日本実験動物学会   常務理事   Domestic

    2020.5 - 2024.6   

  • 獣医事審議会   専門委員   Domestic

    2018.4 - 2021.3   

  • 日本獣医学会   学会誌JVMS編集委員会委員   Domestic

    2016.1 - 2022.1   

  • Councilor   Domestic

    2015.9 - 2023.9   

  • 日本実験動物学会   学会誌Experimental Animals編集委員会委員   Domestic

    2007.5 - 2012.5   

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Academic Activities

  • 組織委員会委員

    第70回日本実験動物学会総会  ( つくば国際会議場 ) 2023.5

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    Type:Competition, symposium, etc. 

    Number of participants:1,100

  • プログラム委員会委員長

    第69回日本実験動物学会総会  ( 仙台国際センター ) 2022.5

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    Type:Competition, symposium, etc. 

    Number of participants:1,050

  • 獣医事審議会専門委員

    Role(s): Review, evaluation

    農林水産省  2018.6 - 2021.3

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    Type:Scientific advice/Review 

  • Journal of Veterinary Medical Science

    2016.1 - 2022.1

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    Type:Academic society, research group, etc. 

  • Experimental Animals

    2007.6 - 2011.6

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    Type:Academic society, research group, etc. 

Research Projects

  • SARS-CoV-2をモデルウイルスとする信頼性基準に従ったin vitro/in vivo非臨床試験実施体制の確立

    2024 - 2025

    AMED-SCARDA「カイコ昆虫モダリティによる低価格な国産組換えワクチンに関する研究開発」

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • ヒト多能性幹細胞評価を革新する非ヒト霊長類-マウス異種間キメラ解析システムの開発

    Grant number:17H03568  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • エネルギー代謝ネットワークの鍵分子USP2の役割解析

    Grant number:15K06805  2015 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • アストロサイト異常に着目した遺伝性・孤発性ALSの病態解明

    Grant number:26293208  2014 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 新しいマクロファージ分子M-modによる2型糖尿病制御

    Grant number:24500494  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 老化促進モデルマウスを用いた加齢による表現型多様性とその原因遺伝子の解析

    Grant number:22500396  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

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Class subject

  • 3年次研究室配属実習

    2023.4 - 2023.9   First semester

  • 3年次研究室配属実習

    2022.4 - 2022.9   First semester

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  沖縄科学技術大学院大学 (OIST) 

  • 2024  宇宙航空研究開発機構(JAXA) 

  • 2023  沖縄科学技術大学院大学 (OIST) 

  • 2023  東北大学大学院医学系研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  東北大学大学院医学系研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  東北大学大学院医学系研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

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Social Activities

  • モデル動物

    2015

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    モデル動物

Media Coverage

  • GNOTOBIOTIC STUDY AT THE RIKEN BRAIN SCIENCE INSTITUTE

    Gnoto News  2019.6

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    GNOTOBIOTIC STUDY AT THE RIKEN BRAIN SCIENCE INSTITUTE

  • 理研BSI、アラキドン酸とDHAの脳発達期の接種不良は統合失調症のリスクを増やす、第6回4DOHaD学会で発表、毛根細胞でマーカー探索開始

    日経バイオテク  2017.9

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    理研BSI、アラキドン酸とDHAの脳発達期の接種不良は統合失調症のリスクを増やす、第6回4DOHaD学会で発表、毛根細胞でマーカー探索開始

  • 理研、自閉症の発症に関与する可能性のある遺伝子としてNLGN1を同定

    日本経済新聞  2017.8

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    理研、自閉症の発症に関与する可能性のある遺伝子としてNLGN1を同定

  • 理化学研究所脳科学総合研究センター動物実験施設の紹介

    オベリスク  2016.6

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    理化学研究所脳科学総合研究センター動物実験施設の紹介

  • 最先端の解析が加速する、省力化を極めた動物実験施設

    Lab Design+ (ラボデザインプラス) vol.10.  2015.7

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    最先端の解析が加速する、省力化を極めた動物実験施設

  • 理研ASI他、化学固定化したフィーダー細胞でマウスiPS細胞を培養、PLoS ONE誌で発表

    日経バイオテク  2012.7

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    理研ASI他、化学固定化したフィーダー細胞でマウスiPS細胞を培養、PLoS ONE誌で発表

  • iPS細胞 多分化能を維持 理研-東工大 新培養技術を開発

    化学工業日報  2012.3

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    iPS細胞 多分化能を維持 理研-東工大 新培養技術を開発

  • 脳科学研究の最先端施設でOSGの殺菌装置セリウスが活躍

    新水生活  2012.1

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    脳科学研究の最先端施設でOSGの殺菌装置セリウスが活躍

  • 理研・脳科学総合研究センターの新動物実験施設の概要と特質

    2011.4

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    理研・脳科学総合研究センターの新動物実験施設の概要と特質

  • 精神疾患とその疾患モデル小動物の表現型解析

    日本実験動物学会ニュース  2008.5

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    精神疾患とその疾患モデル小動物の表現型解析

  • 先端人「細胞狙い撃ちの遺伝子治療開発」

    日本経済新聞  2001.4

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    先端人「細胞狙い撃ちの遺伝子治療開発」

  • Emerging Technology 「狙った細胞に遺伝子を注入」

    日経産業新聞  2001.3

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    Emerging Technology 「狙った細胞に遺伝子を注入」

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Activities contributing to policy formation, academic promotion, etc.

  • 2020.9 - Present  

    AAALAC International Ad hoc Consultant

  • 2019.5 - Present  

    日本実験動物学会 外部検証専門員

  • 2017.4 - 2020.3  

    北里大学獣医学部 動物実験動物倫理委員会 外部委員

  • 2015.9 - Present  

    沖縄科学技術大学院大学 (OIST) 動物実験委員会 外部委員

  • 2015.7 - 2017.3  

    国立研究開発法人宇宙航空研究開発機構 小動物実験専門獣医師

Travel Abroad

  • 2012.1 - 2021.3

    Staying countory name 1:China   Staying institution name 1:上海交通大学