Language：English   Publisher：Hepatology Research  

Aim: To estimate the risks of coronary artery and cerebrovascular diseases in metabolic dysfunction-associated fatty liver disease (MAFLD) using different fatty liver index (FLI) cut-off values in a Japanese population. Methods: We analyzed insurance claims and health checkup data from public medical insurance enrollees aged ≥40 years in seven Japanese municipalities who had undergone a health checkup between April 2015 and March 2022. The MAFLD cases were identified as hepatic steatosis (defined as FLI ≥60 or ≥37) with overweight/obesity, diabetes, or lean/normal weight with metabolic dysregulation. Cox proportional hazards models estimated adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for MAFLD (reference: non-MAFLD) regarding incident coronary artery and cerebrovascular diseases. Covariates included age, sex, smoking habit, low-density lipoprotein cholesterol level, and statin use. Results: The study was undertaken using 163 834 individuals. The HRs of MAFLD for coronary artery disease were 1.44 (95% CI, 1.24–1.67) for FLI ≥ 60 and 1.49 (95% CI, 1.32–1.68) for FLI ≥ 37. The HRs of MAFLD for cerebrovascular disease were 1.58 (95% CI, 1.22–2.05) for FLI ≥ 60 and 1.41 (95% CI, 1.15–1.74) for FLI ≥ 37. In women, neither FLI cut-off was associated with coronary artery disease, and only FLI ≥ 60 was associated with cerebrovascular disease. Conclusions: The MAFLD cases identified using the two FLI cut-off values were at higher risk for coronary artery and cerebrovascular diseases. Asian-specific FLI cut-offs may better identify hepatic steatosis in Japan than Western-specific cut-offs, but there is a need to consider sex differences when determining at-risk subgroups for targeted health interventions.

DOI： 10.1111/hepr.14185

Web of Science

Scopus

PubMed

Event date： 2023.11

Language：Japanese  

Venue：茨城県   Country：Japan  

Event date： 2024.5

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京都   Country：Japan  

Event date： 2024.5

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：沖縄県   Country：Japan  

Event date： 2024.5

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：鹿児島県   Country：Japan  

Event date： 2024.5

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan