Updated on 2024/07/28

Information

 

写真a

 
KIMURA TOMOKO
 
Organization
Faculty of Medical Sciences Department of Health Sciences Assistant Professor
School of Medicine Department of Health Sciences（Concurrent）
Title
Assistant Professor
Profile
I deliver a lecture on hematology, microbiology, immunology, international infectious and genetic testing for students of the laboratory technology sciences. I investigate that　search for new therapeutic agents for myelodysplastic syndrome, development of a novel anti-leukemic therapy targeting the circadian clock genes　and establishment of evaluation method of airway inflammation state in breath condensate.
External link

Degree

  • doctor

Research Interests・Research Keywords

  • Research theme： Establishment of evaluation method of airway inflammation state in breath condensate

    Keyword： breath condensae, eosinophil, basophil, inflammation

    Research period： 2019.4

  • Research theme： Search for novel leukemia treatment by controlling mitochondria-related metabolic factors

    Keyword： mitochondria, leukemia, p32, TFAM

    Research period： 2016.11 - 2018.11

  • Research theme： Development of a novel anti-leukemic therapy targeting the circadian clock genes

    Keyword： circadian rhythm, leukemia

    Research period： 2016.4

  • Research theme： Effects of new drugs on an MDS-derived cell line.

    Keyword： myelodysplastic syndromes， apoptosis, cell cycle

    Research period： 2012.4

Awards

  • 平成29年度学術奨励基金受賞

    2018.7   一般社団法人 福岡県臨床衛生検査技師会  

  • 平成２８年度がん研究助成金　奨励賞

    2017.1   財団法人福岡県すこやか健康事業団  

  • キャンパスベンチャーグランプリ全国大会　TDK賞，MIT賞

    2011.3   キャンパスベンチャーグランプリ  

  • キャンパスベンチャーグランプリ中国大会　最優秀賞

    2010.12   キャンパスベンチャーグランプリ  

Papers

  • Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Reviewed International journal

    Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A. Kay, Kenichiro Itami, and Tsuyoshi Hirota

    Science Advances   5 ( 1 )   2019.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we identified GO289, which strongly lengthened circadian period, as a potent and selective inhibitor of CK2. Phosphoproteomics identified multiple phosphorylation sites inhibited by GO289 on clock proteins, including PER2 S693. Furthermore, GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The x-ray crystal structure of the CK2 alpha-GO289 complex revealed critical interactions between GO289 and CK2-specific residues and no direct interaction of GO289 with the hinge region that is highly conserved among kinases. The discovery of GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.

    DOI： 10.1126

  • Rigosertib induces cell death of an MDS-derived cell line by DNA damage-induced G2/M arrest. Reviewed International journal

    Tomoko Hyoda, Takayuki Tsujioka, Takako Nakahara, Shinichiro Suemori, Shuichiro Okamoto, Mikio Kataoka, Kaoru Tohyama

    Cancer Science   106 ( 3 )   287 - 293   2015.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    A multi-kinase inhibitor, rigosertib (ON 01910.Na) has recently been highlighted as a novel type of anti-cancer agent for the treatment of the myelodysplastic syndromes (MDS), but its action mechanisms remain to be clarified. We investigated the invitro effects of rigosertib on an MDS-derived cell line MDS-L and a myeloid leukemia cell line HL-60. Rigosertib suppressed the proliferation of both HL-60 and MDS-L cells and induced apoptosis by inhibition of the PI3 kinase/Akt pathway. As the effects on cell cycle, rigosertib treatment promoted the phosphorylation of histone H2AX and led to the DNA damage-induced G2/M arrest. In addition, an immunofluorescence staining study demonstrated the abnormal localization of aurora A kinase, suggesting that rigosertib causes perturbation of spindle assembly and deregulated mitotic patterns towards cell cycle arrest and apoptosis. We also found that rigosertib exerted growth inhibitory effects on two lymphoid cell lines, Jurkat and Ramos. We further examined the molecular pathways influenced by rigosertib from the gene expression profiling data of MDS-L cells and found a possible involvement of rigosertib treatment in the upregulation of the genes related to microtubule kinetics and the downregulation of the mRNA degradation system. The gene set enrichment analysis showed the suppression of nonsense-mediated mRNA decay (NMD) as the most significantly affected gene set. These data provide a new aspect and a potential utility of rigosertib for the treatment of refractory hematopoietic malignancies.

  • Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma. Reviewed International journal

    Tomoe Iio, Misako Shibakura, Kanayo Yokota, Michinori Aoe, Tomoko Hyoda, Ryoko Shinohata, Arihiko Kanehiro, Mitsune Tanimoto, Mikio Kataoka

    Life science   108 ( 2 )   109 - 115   2014.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

Books

  • 臨床検査の基礎技術

    中原 貴子, 近末 久美子, 小郷 正則, 永瀬 澄香, 迎 由利子, 衣川 菜美, 兵田 朋子, 玉井 利奈（Role：Joint author）

    ふくろう出版  2015.4 

    　More details

    Language：Japanese   Book type：General book, introductory book for general audience

Presentations

  • AXL inhibitor exhibits an antitumor effects on an MDS-derived cell line through DNA damage response

    木村朋子, #龍美玖璃, #福元沙織, #湯田遼介, 三浦浩一, 細川健太郎, 八尾尚幸, @岡本秀一郎, @宮野佳, @渡邉昂, @通山薫, 内海健

    第84回日本血液学会  2022.10 

    　More details

    Event date： 2022.10

    Language：Japanese  

    Venue：福岡国際会議場   Country：Japan  

  • Antitumor effects of AXL inhibitor (TP-0903) on a MDS-derived cell line

    木村 朋子, #林 麟太郎, #平井 遥, #龍 美玖璃, 安田 洋子, 三浦 浩一, 内海 健

    第83回日本血液学会  2021.9 

    　More details

    Event date： 2021.9

    Language：Japanese  

    Country：Japan  

  • AXL阻害剤の骨髄異形成症候群細胞株における抗腫瘍効果

    木村 朋子, #平井 遥, #林 麟太郎, 内海 健

    第22回日本検査血液学会  2021.9 

    　More details

    Event date： 2021.9

    Language：Japanese  

    Country：Japan  

  • 概日リズム制御分子を標的とした新規白血病治療薬の開発

    木村（兵田）朋子

    第29回福岡県医学検査学会  2019.6 

    　More details

    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：のがみプレジデントホテル（飯塚市）   Country：Japan  

  • The circadian modulating drug exhibits an anti leukemia effect through the mitochondrial oxidation

    兵田朋子,國崎祐哉, 細川健太郎, 廣田毅, 後藤和人, 瀬戸山大樹, 康東天, 新井文用

    第80回日本血液学会  2018.10 

    　More details

    Event date： 2018.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪国際会議場   Country：Japan  

  • Development of a novel anti-leukemic therapy targeting the circadian clock genes

    Tomoko Hyoda, Yuya Kunisaki, Kentaro Hosokawa, Tsuyoshi Hirota, Kazuhito Gotoh, Fumio Arai

    第79回日本血液学会  2017.10 

    　More details

    Event date： 2017.10

    Language：Japanese  

    Venue：東京国際フォーラム   Country：Japan  

  • Development of a novel anti-leukemic therapy targeting the circadian clock genes

    兵田 朋子, 國﨑 祐哉, 細川 健太郎, 新井 文用

    第15回幹細胞シンポジウム  2017.5 

    　More details

    Event date： 2017.5

    Language：Japanese  

    Venue：東京大学　伊藤国際学術研究センター   Country：Japan  

  • プロスタグランジン刺激によるEoL-1細胞の好酸球分化と主要塩基性蛋白(MBP)の発現

    @兵田 朋子, @柴倉 美砂子, @青江 伯規, @中川 尚久, @中原 貴子, @佐藤 妃映, @飯尾 友愛, @片岡 幹男

    日本検査血液学会  2011.7 

    　More details

    Language：Japanese  

    Country：Japan  

  • 呼気凝縮液(EBC)による気管支喘息患者の気道炎症の診断

    兵田 朋子, @飯尾 友愛, @青江 伯規, @柴倉 美砂子, @中原 貴子, @中川 尚久, @片岡 幹男

    日本臨床検査医学会  2011.10 

    　More details

    Language：Japanese  

    Country：Japan  

  • MDS細胞株におけるON 01910.Na（リゴサチブ）の効果

    兵田 朋子, @辻岡貴之, @久山亜紀, @末盛晋一郎, @通山薫

    第75回 日本血液学会  2013.10 

    　More details

    Language：Japanese  

    Country：Japan  

  • 新規抗腫瘍薬rigosertibのMDS細胞株に対する効果

    兵田 朋子, @辻岡貴之, @末盛晋一郎, @通山薫

    第14回 Okayama Hematology Conference  2014.7 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

▼display all

Professional Memberships

  • 日本臨床衛生検査技師学会

  • 日本検査血液学会

  • 日本血液学会

Committee Memberships

  • 日本臨床衛生検査技師会   福岡支部遺伝子部門副班長, 血液部門委員   Domestic

    2016.6 - 2019.3   

Academic Activities

  • 座長

    第70回日本医学検査学会  （ Japan ） 2021.5 - 2021.6

    　More details

    Type：Competition, symposium, etc. 

Research Projects

  • 造血器腫瘍細胞株におけるAXL阻害剤の効果

    2022

    令和4年度 研究補助者雇用支援（短期）（春）

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 造血器腫瘍細胞株におけるAXL阻害剤の効果

    2022

    令和4年度 研究補助者雇用支援（短期）（秋）

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • AXL活性の制御による骨髄異形成症候群の病態解明及び新たな治療戦略

    Grant number：21K15647  2021 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 造血器腫瘍細胞株におけるAXL阻害剤の効果

    2021

    令和3年度 研究補助者雇用支援（短期）（春）

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 造血器腫瘍細胞株におけるAXL阻害剤の効果

    2021

    令和3年度 研究補助者雇用支援（短期）（秋）

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 概日リズム制御分子を標的とした新規白血病治療薬の開発

    2020

    出産・育児復帰者支援

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 概日リズム制御分子を標的とした新規白血病治療薬の開発

    Grant number：18K15392  2018 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 概日リズム制御分子を標的とした新規白血病治療薬の開発

    2018

    福岡県臨床衛生検査技師会 学術奨励金

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 骨髄異形成症候群における新規薬剤ポマリドミドの薬効プロファイル評価因子の探索

    2017 - 2018

    平成２８年度がん研究助成金（福岡県すこやか健康事業団）

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 課題解決型高度人材養成プログラム「実践能力強化型チーム医療加速プログラム」

    2014.9 - 2019.3

    九州大学大学院 

    　 More details

    Authorship：Coinvestigator(s) 

▼display all

Educational Activities

  • I deliver a lecture on hematology, microbiology, Basic Inspection Technology for students of the laboratory technology sciences.

Class subject

  • 検査基礎技術および実習

    2024.4 - 2024.9   First semester

  • 検査基礎技術および実習

    2023.4 - 2023.9   First semester

  • 国際感染症学および実習

    2023.4 - 2023.9   First semester

  • 臨床検査学概論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 一般検査学および実習

    2022.10 - 2023.3   Second semester

  • 血液検査学実習

    2022.10 - 2023.3   Second semester

  • 医用工学・情報概論実験

    2022.10 - 2022.12   Fall quarter

  • 国際感染症学および実習

    2022.4 - 2022.9   First semester

  • 検査基礎技術

    2022.4 - 2022.9   First semester

  • 臨床検査学概論Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 血液検査学実習

    2021.10 - 2022.3   Second semester

  • 臨床微生物学および実習

    2021.4 - 2021.9   First semester

  • 検査基礎技術

    2021.4 - 2021.9   First semester

  • 臨床検査学概論Ⅰ

    2021.4 - 2021.6   Spring quarter

  • 臨床免疫学および実習

    2020.10 - 2021.3   Second semester

  • 臨床検査学概論Ⅰ

    2020.10 - 2020.12   Fall quarter

  • 遺伝子検査学実験

    2020.10 - 2020.12   Fall quarter

  • 臨床微生物学および実習

    2020.4 - 2020.9   First semester

  • 血液検査学実習

    2020.4 - 2020.9   First semester

  • 国際感染症学および実習

    2020.4 - 2020.9   First semester

  • 臨床微生物学および実習

    2019.4 - 2019.9   First semester

  • 血液検査学実習

    2019.4 - 2019.9   First semester

  • 国際感染症学および実習

    2019.4 - 2019.9   First semester

  • 臨床免疫学および実習

    2018.10 - 2019.3   Second semester

  • 遺伝子検査学実験

    2018.10 - 2018.12   Fall quarter

  • 臨床微生物学および実習

    2018.4 - 2018.9   First semester

  • 血液検査学実習

    2018.4 - 2018.9   First semester

  • 国際感染症学および実習

    2018.4 - 2018.9   First semester

  • 臨床検査学概論Ⅱ

    2017.10 - 2018.3   Second semester

  • 血液検査学

    2017.10 - 2018.3   Second semester

  • 血液検査学実習

    2017.10 - 2018.3   Second semester

  • 臨床免疫学実習

    2017.10 - 2018.3   Second semester

  • 遺伝子検査学実験

    2017.10 - 2018.3   Second semester

  • 臨床微生物学および実習

    2017.4 - 2017.9   First semester

  • 臨床検査学概論Ⅰ

    2017.4 - 2017.9   First semester

  • 遺伝子検査学実験

    2016.10 - 2017.3   Second semester

  • 血液検査学実習

    2016.10 - 2017.3   Second semester

  • 血液検査学Ⅰ

    2016.10 - 2017.3   Second semester

  • 臨床免疫学実習

    2016.10 - 2017.3   Second semester

  • 国際感染症学および実習

    2016.10 - 2017.3   Second semester

  • 臨床微生物学および実習

    2016.4 - 2016.9   First semester

  • 血液検査学Ⅰ

    2015.10 - 2016.3   Second semester

  • 血液検査学実習

    2015.10 - 2016.3   Second semester

▼display all

FD Participation

  • 2022.9   Role：Participation   Title：保健学部門における国際化の推進とグローバル人材の育成

    Organizer：Undergraduate school department

  • 2022.3   Role：Participation   Title：メンタルヘルス講演会

    Organizer：University-wide

  • 2021.9   Role：Participation   Title：With/Postコロナ時代の保健学実習・講義のあり方

    Organizer：Undergraduate school department

  • 2020.9   Role：Participation   Title：遠隔授業の現状を踏まえた今後の活用に向けて！

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.9   Role：Participation   Title：医学部保健学科の入試の在り方〜新入試制度QUBE導入に向けて〜

    Organizer：Undergraduate school department

  • 2017.9   Role：Participation   Title：三専攻共通科目の在り方について

    Organizer：Undergraduate school department

  • 2016.9   Role：Participation   Title：部局の国際化を考える

    Organizer：Undergraduate school department

  • 2016.3   Role：Participation   Title：大学における情報セキュリティについて

    Organizer：Undergraduate school department

  • 2015.9   Role：Participation   Title：教育力セルフマネジメントプログラム

    Organizer：Undergraduate school department

▼display all

Other educational activity and Special note

  • 2019  Class Teacher  学部

  • 2018  Class Teacher  学部

  • 2017  Class Teacher  学部

Social Activities

  • 血液のひみつ

    第15回九州大学医学部保健学科公開講座  保健学科本館  2017.9

    　More details

    Audience：General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture