MAEDA TAKAHIRO
Banner URL
Organization
Faculty of Medical Sciences Research Center for Precision Medicine Professor
School of Medicine Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）
Title
Professor
Homepage
External link
ORCID
Degree
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MD., Ph.D.
Research History
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2007-2011 Assistant Professor, Department of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA 2011-2016 Assistant Professor of Medicine, Harvard Medical School, Hematology Division, Brigham and Women's Hospital, Boston, MA, USA 2012-2016 Affiliated Faculty Member, Harvard Stem Cell Institute, Boston, MA 2012-2016 Member, Dana-Farber/Harvard Cancer Center, Boston, MA 2013-2016 Associate Member, Broad Institute, Cambridge, MA
Research Interests・Research Keywords
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Research theme：Goals of our research projects are to: 1. Identify novel targets for acute leukemia therapy. 2. Determine molecular mechanisms underlying fetal global repression in adult erythroid cells. 3. Determine the role of the transcription factor LRF/ZBTB7A in hematopoietic cellular differentiation.
Keyword：Acute leukemia, Sickle cell disease, Differentiation of hematopoietic lineage cells
Research period： 2016.10
Awards
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Japanese Cancer Association Mauvernay Award
2018.9
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American Society of Hematology Scholar Award
2008.6 American Society of Hematology
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V Foundation Scholar Award
2007.6 V Foundation
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Memorial Sloan-Kettering Cancer Center Research Fellow Award
2005.6
Papers
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Impact of Genomic Alterations on Efficacy of Trastuzumab Deruxtecan Against Human Epidermal Growth Factor Receptor-2–Positive Advanced Gastric Cancer
( 8 ) 2024.5
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ctDNA improves prognostic prediction in relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone.
Yasunori Kogure, Handa H, Yuta Ito, Masaki Ri, Horigome Y, Iino M, Yoriko Harazaki, Takahiro Kobayashi, Masahiro Abe, Tadao Ishida, Ito S, Iwasaki H, Kuroda J, Shibayama H, Sunami K, Takamatsu H, Tamura H, Toshi, Akagi K, Tomohiro Shinozaki, Yoshida T, Mori I, SHINSUKE IIDA, Takahiro Maeda, Keisuke Kataoka
Blood 2024.3
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A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence.
Sunami K, Naito Y, Saigusa Y, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Hirata M, Ito M, Kozuki T, Sakashita H, Horinouchi H, Okuma Y, Takashima A, Kubo T, Hironaka S, Segawa Y, Yakushijin Y, Bando H, Makiyama A, Suzuki T, Kinoshita I, Kohsaka S, Ohe Y, Ishioka C, Yamamoto K, Tsuchihara K, Yoshino T
JAMA oncology 2024.1
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A prospective, multicenter, observational study of ixazomib plus lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in Japan.
Horigome Y, Iino M, Harazaki Y, Kobayashi T, Handa H, Hiramatsu Y, Kuroi T, Tanimoto K, Matsue K, Abe M, Ishida T, Ito S, Iwasaki H, Kuroda J, Shibayama H, Sunami K, Takamatsu H, Tamura H, Hayashi T, Akagi K, Maeda T, Yoshida T, Mori I, Shinozaki T, SHINSUKE IIDA
Annals of hematology 2023.9
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CELMoD for ALL: an exciting prospect
Takahiro Maeda
Blood 2023.8
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MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins
Yosuke Komata, Akinori Kanai, Takahiro Maeda, Toshiya Inaba, Akihiko Yokoyama
Nature Communications 2023.4
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Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance.
Nakao F, Setoguchi K, Semba Y, Yamauchi T, Nogami J, Sasaki K, Imanaga H, Terasaki T, Miyazaki M, Shigeki Hirabayashi, Miyawaki K, Kikushige Y, Masuda T, Akashi K, Takahiro Maeda
Leukemia 2023.3
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RHAMM marks proliferative subpopulation of human colorectal cancer stem cells.
Michitaka Nakano, Taguchi R, Kikushige Y, Taichi Isobe, Kohta Miyawaki, Mizuno S, Tsuruta N, Hanamura F, Yamaguchi K, Yamauchi T, Hiroshi Ariyama, Kusaba H, Nakamura M, Maeda T, Kuo CJ, Eishi Baba, Akashi K
Cancer science 2023.3
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Concordance Between Recommendations From Multidisciplinary Molecular Tumor Boards and Central Consensus for Cancer Treatment in Japan.
Naito Y, Sunami K, Kage H, Komine K, Amano T, Imai M, Koyama T, Ennishi D, Kanai M, Kenmotsu H, Maeda T, Morita S, Sakai D, Watanabe K, Shirota H, Kinoshita I, Yoshioka M, Mamesaya N, Ito M, Kohsaka S, Saigusa Y, Yamamoto K, Hirata M, Tsuchihara K, Yoshino T
JAMA network open 2022.12
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Chronological improvement in precision oncology implementation in Japan
Kuniko Sunami, Yoichi Naito, Keigo Komine, Toraji Amano, Daisuke Ennishi, Mitsuho Imai, Hidenori Kage, Masashi Kanai, Hirotsugu Kenmotsu, Takafumi Koyama, Takahiro Maeda, Sachi Morita, Daisuke Sakai, Shinji Kohsaka, Katsuya Tsuchihara, Yusuke Saigusa, Takayuki Yoshino
Cancer Science 2022.9
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Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation
Shiho Taniguchi, Sae Utsumi, Yu Kochi, Yuki Taya, Yasuo Mori, Yu-ichiro Semba, Takeshi Sugio, Kohta Miyawaki, Yoshikane Kikushige, Yuya Kunisaki, Goichi Yoshimoto, Akihiko Numata, Koji Kato, Naoyuki Uchida, Takahiro Maeda, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi
International Journal of Hematology 2022.9
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Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model
Kyoko Yamaguchi, Tomoyasu Yoshihiro, Hiroshi Ariyama, Mamoru Ito, Michitaka Nakano, Yuichiro Semba, Jumpei Nogami, Kenji Tsuchihashi, Takuji Yamauchi, Shohei Ueno, Taichi Isobe, Koji Shindo, Taiki Moriyama, Kenoki Ohuchida, Masafumi Nakamura, Yoshihiro Nagao, Tetsuo Ikeda, Makoto Hashizume, Hiroyuki Konomi, Takehiro Torisu, Takanari Kitazono, Tomohiro Kanayama, Hiroyuki Tomita, Yoshinao Oda, Hitoshi Kusaba, Takahiro Maeda, Koichi Akashi, Eishi Baba
Gastric Cancer 25 ( 5 ) 862 - 878 2022.9
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Expert panel consensus recommendations on the use of circulating tumor <scp>DNA</scp> assays for patients with advanced solid tumors
Mitsuho Imai, Yoshiaki Nakamura, Kuniko Sunami, Hidenori Kage, Keigo Komine, Takafumi Koyama, Toraji Amano, Daisuke Ennishi, Masashi Kanai, Hirotsugu Kenmotsu, Takahiro Maeda, Sachi Morita, Daisuke Sakai, Hideaki Bando, Akitaka Makiyama, Tatsuya Suzuki, Makoto Hirata, Shinji Kohsaka, Katsuya Tsuchihara, Yoichi Naito, Takayuki Yoshino
Cancer Science 2022.9
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A preterm newborn‐onset juvenile myelomonocytic leukemia‐like myeloproliferation with PTPN11 mutation
Shunsuke Yamamoto, Shingo Nakao, Hirosuke Inoue, Yuhki Koga, Kanako Kojima‐Ishii, Yuichiro Semba, Takahiro Maeda, Koichi Akashi, Shouichi Ohga
2022.8
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Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC
Jake C. Swartzel, Michael J. Bond, Andreas P. Pintado-Urbanc, Mehana Daftary, Mackenzie W. Krone, Todd Douglas, Evan J. Carder, Joshua T. Zimmer, Takahiro Maeda, Matthew D. Simon, Craig M. Crews
ACS Chemical Biology 17 ( 7 ) 1789 - 1798 2022.7
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A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL
Kohta Miyawaki, Koji Kato, Takeshi Sugio, Kensuke Sasaki, Hiroaki Miyoshi, Yuichiro Semba, Yoshikane Kikushige, Yasuo Mori, Yuya Kunisaki, Hiromi Iwasaki, Toshihiro Miyamoto, Frank C Kuo, Jon C. Aster, Koichi Ohshima, Takahiro Maeda, Koichi Akashi
Blood Advances 2021.10
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Optimization of lymphapheresis for manufacturing autologous CAR-T cells
Ikumi Yamanaka, Takuji Yamauchi, Tomoko Henzan, Teppei Sakoda, Kyoko Miyamoto, Hiroyuki Mishima, Hiroaki Ono, Yuhki Koga, Yasuhiro Nakashima, Koji Kato, Toshihiro Miyamoto, Shinichi Mizuno, Yoshihiro Ogawa, Shouichi Ohga, Koichi Akashi, Takahiro Maeda, Yuya Kunisaki
International Journal of Hematology 114 ( 4 ) 449 - 458 2021.10
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Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL
Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, ELs Verhoeyen, Koichi Akashi, Takahiro Maeda
Blood 2021.9
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Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch
Tomoko Henzan, Takuji Yamauchi, Ikumi Yamanaka, Teppei Sakoda, Yuichiro Semba, Masayasu Hayashi, Yoshikane Kikushige, Hiroyuki Mishima, Masataka Ishimura, Yuhki Koga, Toshihiro Miyamoto, Shouichi Ohga, Koichi Akashi, Takahiro Maeda, Yuya Kunisaki
International Journal of Hematology 2021.8
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Targeting leukemia-specific dependence on the de novo purine synthesis pathway
Takuji Yamauchi, Kohta Miyawaki, Yuichiro Semba, Masatomo Takahashi, Yoshihiro Izumi, Jumpei Nogami, Fumihiko Nakao, Takeshi Sugio, Kensuke Sasaki, Luca Pinello, Daniel E. Bauer, Takeshi Bamba, Koichi Akashi, Takahiro Maeda
Leukemia 2021.8
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Platelet decrease and efficacy of platelet‐rich plasma return following peripheral blood stem cell apheresis
2021.6
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Clinical features and chromosomal/genetic aberration in adult acute lymphoblastic leukemia in Japan: results of Fukuoka Blood & Marrow Transplant Group Studies ALL MRD 2002 and 2008
Satoshi Morishige, Toshihiro Miyamoto, Tetsuya Eto, Naoyuki Uchida, Tomohiko Kamimura, Yasuhiko Miyazaki, Ryosuke Ogawa, Hirokazu Okumura, Tomoaki Fujisak, Hiromi Iwasaki, Noriaki Kawano, Atsushi Wake, Takanori Ohta, Yasushi Takamatsu, Toshiro Kurokawa, Yoshikiyo Ito, Takahiro Maeda, Koichi Akashi, Koji Nagafuji
International Journal of Hematology 2021.3
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The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan
Kuniko Sunami, Yoichi Naito, Eriko Aimono, Toraji Amano, Daisuke Ennishi, Hidenori Kage, Masashi Kanai, Keigo Komine, Takafumi Koyama, Takahiro Maeda, Sachi Morita, Daisuke Sakai, Shinji Kohsaka, Katsuya Tsuchihara, Takayuki Yoshino
International Journal of Clinical Oncology 26 ( 3 ) 443 - 449 2021.3
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Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion
Shuki Oya, Satoshi Morishige, Hidetoshi Ozawa, Kensuke Sasaki, Yuichiro Semba, Yoshitaka Yamasaki, Takayuki Nakamura, Kazutoshi Aoyama, Ritsuko Seki, Fumihiko Mouri, Koichi Osaki, Toshihiro Miyamoto, Takahiro Maeda, Koji Nagafuji
International Journal of Hematology 113 ( 2 ) 285 - 289 2021.2
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Outcome predictors after retransplantation in relapsed acute lymphoblastic leukemia: a multicenter, retrospective study
Yasuo Mori, Kensuke Sasaki, Yoshikiyo Ito, Takuro Kuriyama, Toshiyuki Ueno, Masanori Kadowaki, Takatoshi Aoki, Takeshi Sugio, Goichi Yoshimoto, Koji Kato, Takahiro Maeda, Koji Nagafuji, Koichi Akashi, Toshihiro Miyamoto
Annals of Hematology 100 ( 1 ) 197 - 208 2021.1
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Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia
135 ( 24 ) 2146 - 2158 2020.6
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A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells
Fumiaki Jinnouchi, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Michitaka Nakano, Chika Iwamoto, Teppei Obara, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Eishi Baba, Koichi Akashi, Katsuto Takenaka
Blood 135 ( 19 ) 1661 - 1672 2020.5
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Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma
18 ( 9 ) 1555 - 1564 2019.9
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Successful rescue transplantation with desensitization procedure after primary graft failure due to donor-specific antibody
Mariko Minami, Takumi Matsushima, Yasuo Mori, Daisuke Ishihara, Fumiaki Jinnnouchi, Katsuto Takenaka, Tomoko Henzan, Goichi Yoshimoto, Akihiko Numata, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Koichi Akashi
Bone Marrow Transplantation 54 ( 8 ) 1374 - 1376 2019.8
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Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
Falak Sher, Mir Hossain, Davide Seruggia, Vivien A. C. Schoonenberg, Qiuming Yao, Paolo Cifani, Laura M. K. Dassama, Mitchel A. Cole, Chunyan Ren, Divya S. Vinjamur, Claudio Macias-Trevino, Kevin Luk, Connor McGuckin, Patrick G. Schupp, Matthew C. Canver, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Scot A. Wolfe, Luca Pinello, Takahiro Maeda, Alex Kentsis, Stuart H. Orkin, Daniel E. Bauer
Nature Genetics 51 ( 7 ) 1149 - 1159 2019.7
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DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways and protein complexes from CRISPR screens
Matthew C Canver, Daniel E Bauer, Takahiro Maeda, Luca Pinello
Bioinformatics 35 ( 11 ) 1981 - 1984 2019.6
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Molecular pathogenesis of disease progression in MLL-rearranged AML
Shinichi Kotani, Akinori Yoda, Ayana Kon, Keisuke Kataoka, Yotaro Ochi, Yusuke Shiozawa, Cassandra Hirsch, June Takeda, Hiroo Ueno, Tetsuichi Yoshizato, Kenichi Yoshida, Masahiro M. Nakagawa, Yasuhito Nannya, Nobuyuki Kakiuchi, Takuji Yamauchi, Kosuke Aoki, Yuichi Shiraishi, Satoru Miyano, Takahiro Maeda, Jaroslaw P. Maciejewski, Akifumi Takaori-Kondo, Seishi Ogawa, Hideki Makishima
Leukemia 33 ( 3 ) 612 - 624 2019.3
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Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer
Michitaka Nakano, Yoshikane Kikushige, Kohta Miyawaki, Yuya Kunisaki, Shinichi Mizuno, Katsuto Takenaka, Shingo Tamura, Yuta Okumura, Mamoru Ito, Hiroshi Ariyama, Hitoshi Kusaba, Masafumi Nakamura, Takahiro Maeda, Eishi Baba, Koichi Akashi
Oncogene 38 ( 6 ) 780 - 793 2019.2
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Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation
Yasuo Mori, Goichi Yoshimoto, Jun-Ichiro Yuda, Masayasu Hayashi, Jun Odawara, Takuro Kuriyama, Takeshi Sugio, Kohta Miyawaki, Kenjiro Kamezaki, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Takahiro Maeda, Toshihiro Miyamoto, Koichi Akashi
Leukemia & Lymphoma 60 ( 1 ) 271 - 273 2019.1
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CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis
Genome Biology 19 ( 1 ) 2018.12
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Human Herpes Virus-6–Associated Encephalitis/Myelitis Mimicking Calcineurin Inhibitor–Induced Pain Syndrome in Allogeneic Stem Cell Transplantation Recipients
24 ( 12 ) 2540 - 2548 2018.12
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Gastrointestinal Graft-versus-Host Disease Is a Risk Factor for Postengraftment Bloodstream Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Yasuo Mori, Goichi Yoshimoto, Ruriko Nishida, Takeshi Sugio, Kohta Miyawaki, Takahiro Shima, Yoji Nagasaki, Noriko Miyake, Yukiko Harada, Yuya Kunisaki, Kenjiro Kamezaki, Akihiko Numata, Koji Kato, Motoaki Shiratsuchi, Takahiro Maeda, Katsuto Takenaka, Hiromi Iwasaki, Nobuyuki Shimono, Koichi Akashi, Toshihiro Miyamoto
Biology of Blood and Marrow Transplantation 24 ( 11 ) 2302 - 2309 2018.11
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Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS
Takeshi Sugio, Kohta Miyawaki, Koji Kato, Kensuke Sasaki, Kyohei Yamada, Javeed Iqbal, Toshihiro Miyamoto, Koichi Ohshima, Takahiro Maeda, Hiroaki Miyoshi, Koichi Akashi
Blood Advances 2 ( 17 ) 2242 - 2252 2018.9
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Successful treatment of Ph ALL with hematopoietic stem cell transplantation from the same HLA-haploidentical related donor of previous liver transplantation
Kensuke Sasaki, Yasuo Mori, Goichi Yoshimoto, Teppei Sakoda, Koji Kato, Kyoko Inadomi, Kenjiro Kamezaki, Katsuto Takenaka, Hiromi Iwasaki, Takahiro Maeda, Toshihiro Miyamoto, Koichi Akashi
Leukemia & Lymphoma 59 ( 8 ) 2005 - 2007 2018.8
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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al-Raqad, Manami Maeda, Vivien A.C. Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda
Cancer Cell 33 ( 3 ) 386 - 400.e5 2018.3
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Identification of unipotent megakaryocyte progenitors in human hematopoiesis
Kohta Miyawaki, Hiromi Iwasaki, Takashi Jiromaru, Hirotake Kusumoto, Ayano Yurino, Takeshi Sugio, Yasufumi Uehara, Jun Odawara, Shinya Daitoku, Yuya Kunisaki, Yasuo Mori, Yojiro Arinobu, Hirofumi Tsuzuki, Yoshikane Kikushige, Tadafumi Iino, Koji Kato, Katsuto Takenaka, Toshihiro Miyamoto, Takahiro Maeda, Koichi Akashi
Blood 129 ( 25 ) 3332 - 3343 2017.6
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Erythropoietin signaling regulates heme biosynthesis
Jacky Chung, Johannes G Wittig, Alireza Ghamari, Manami Maeda, Tamara A Dailey, Hector Bergonia, Martin D Kafina, Emma E Coughlin, Catherine E Minogue, Alexander S Hebert, Liangtao Li, Jerry Kaplan, Harvey F Lodish, Daniel E Bauer, Stuart H Orkin, Alan B Cantor, Takahiro Maeda, John D Phillips, Joshua J Coon, David J Pagliarini, Harry A Dailey, Barry H Paw
eLife 6 2017.5
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Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
Takeshi Masuda, Xin Wang, Manami Maeda, Matthew C. Canver, Falak Sher, Alister P. W. Funnell, Chris Fisher, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Catherine Zhu, Ryo Kurita, Yukio Nakamura, Jian Xu, Douglas R. Higgs, Merlin Crossley, Daniel E. Bauer, Stuart H. Orkin, Peter V. Kharchenko, Takahiro Maeda
Science 351 ( 6270 ) 285 - 289 2016.1
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Notch signal strength controls cell fate in the haemogenic endothelium
Nature Communications 6 ( 1 ) 2015.12
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, Diane D. Chen, Patrick G. Schupp, Divya S. Vinjamur, Sara P. Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart H. Orkin, Daniel E. Bauer
Nature 527 ( 7577 ) 192 - 197 2015.11
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Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
18 ( 7 ) 978 - 987 2015.7
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A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells
Jlenia Guarnerio, Luisa Riccardi, Riccardo Taulli, Takahiro Maeda, Guocan Wang, Robin M. Hobbs, Min Sup Song, Paolo Sportoletti, Rosa Bernardi, Roderick T. Bronson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Andrea Lunardi, Pier Paolo Pandolfi
Cancer Discovery 5 ( 4 ) 396 - 409 2015.4
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Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology
Y. Ishikawa, M. Maeda, M. Pasham, F. Aguet, S. K. Tacheva-Grigorova, T. Masuda, H. Yi, S.-U. Lee, J. Xu, J. Teruya-Feldstein, M. Ericsson, A. Mullally, J. Heuser, T. Kirchhausen, T. Maeda
Haematologica 100 ( 4 ) 439 - 451 2015.4
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Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells*
Matthew C. Canver, Daniel E. Bauer, Abhishek Dass, Yvette Y. Yien, Jacky Chung, Takeshi Masuda, Takahiro Maeda, Barry H. Paw, Stuart H. Orkin
Journal of Biological Chemistry 289 ( 31 ) 21312 - 21324 2014.8
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Utility of LRF/Pokemon and NOTCH1 Protein Expression in the Distinction Between Nodular Lymphocyte-Predominant Hodgkin Lymphoma and Classical Hodgkin Lymphoma
Olga Bohn, Takahiro Maeda, Alexander Filatov, Andrea Lunardi, Pier Paolo Pandolfi, Julie Teruya-Feldstein
International Journal of Surgical Pathology 22 ( 1 ) 6 - 11 2014.2
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Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation
Cell Metabolism 17 ( 3 ) 343 - 352 2013.3
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LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Sung-Uk Lee, Manami Maeda, Yuichi Ishikawa, Sierra Min Li, Anne Wilson, Adrian M. Jubb, Nagisa Sakurai, Lihong Weng, Emma Fiorini, Freddy Radtke, Minhong Yan, H. Robson MacDonald, Ching-Cheng Chen, Takahiro Maeda
Blood 121 ( 6 ) 918 - 929 2013.2
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Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
Cancer Cell 21 ( 4 ) 577 - 592 2012.4
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Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development
K. Tsuji-Takechi, T. Negishi-Koga, E. Sumiya, A. Kukita, S. Kato, T. Maeda, P. P. Pandolfi, K. Moriyama, H. Takayanagi
Proceedings of the National Academy of Sciences 109 ( 7 ) 2561 - 2566 2012.2
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The LRF transcription factor regulates mature B cell development and the germinal center response in mice
Nagisa Sakurai, Manami Maeda, Sung-Uk Lee, Yuichi Ishikawa, Min Li, John C. Williams, Lisheng Wang, Leila Su, Mai Suzuki, Toshiki I. Saito, Shigeru Chiba, Stefano Casola, Hideo Yagita, Julie Teruya-Feldstein, Shinobu Tsuzuki, Ravi Bhatia, Takahiro Maeda
Journal of Clinical Investigation 121 ( 7 ) 2583 - 2598 2011.7
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LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
Takahiro Maeda, Keisuke Ito, Taha Merghoub, Laura Poliseno, Robin M. Hobbs, Guocan Wang, Lin Dong, Manami Maeda, Louis C. Dore, Arthur Zelent, Lucio Luzzatto, Julie Teruya-Feldstein, Mitchell J. Weiss, Pier Paolo Pandolfi
Developmental Cell 17 ( 4 ) 527 - 540 2009.10
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Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF
Takahiro Maeda, Taha Merghoub, Robin M. Hobbs, Lin Dong, Manami Maeda, Johannes Zakrzewski, Marcel R.M. van den Brink, Arthur Zelent, Hirokazu Shigematsu, Koichi Akashi, Julie Teruya-Feldstein, Giorgio Cattoretti, Pier Paolo Pandolfi
Science 316 ( 5826 ) 860 - 866 2007.5
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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression
Takahiro Maeda, Robin M. Hobbs, Taha Merghoub, Ilhem Guernah, Arthur Zelent, Carlos Cordon-Cardo, Julie Teruya-Feldstein, Pier Paolo Pandolfi
Nature 433 ( 7023 ) 278 - 285 2005.1
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Histone deacetylase 3 associates with and represses the transcription factor GATA-2
Yukiyasu Ozawa, Masayuki Towatari, Shinobu Tsuzuki, Fumihiko Hayakawa, Takahiro Maeda, Yasuhiko Miyata, Mitsune Tanimoto, Hidehiko Saito
Blood 98 ( 7 ) 2116 - 2123 2001.10
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Histone Acetylation Induced by Granulocyte Colony-Stimulating Factor in a MAP Kinase-Dependent Manner
Yasuhiko Miyata, Masayuki Towatari, Takahiro Maeda, Yukiyasu Ozawa, Hidehiko Saito
Biochemical and Biophysical Research Communications 283 ( 3 ) 655 - 660 2001.5
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Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Reviewed
Takahiro Maeda, Masayuki Towatari, Hiroshi Kosugi, Hidehiko Saito
Blood 96 ( 12 ) 3847 - 3856 2000.12
Presentations
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Harnessing functional genomics to uncover potential targets for AML therapy. Invited
Takahiro Maeda
2024.10
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Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization. International conference
Terasaki T, Semba Y, Sasaki K, Setoguchi K, Yamauchi T, Imanaga H, Nakao F, Hirabayashi S, Nogami J, Akashi K, Maeda T.
American Society of Hematology Annual Meeting, San Diego, CA 2023.12
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The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53-Mutated AML. International conference
SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Ogawa S, Akashi K, Maeda T.
American Society of Hematology Annual Meeting, San Diego, CA 2023.12
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Genome-Wide CRISPR-Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis by Regulating MCL1 mRNA Cellular Localization. Invited International conference
Terasaki T, Semba Y, Sasaki K, Setoguchi K, Yamauchi T, Imanaga H, Nakao F, Hirabayashi S, Nogami J, Akashi K, Maeda T.
FASEB Hematologic Malignancies Conference 2023.8
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The XPO7/NPAT axis as a potential therapeutic target for TP53-mutated AML. Invited International conference
Yuichiro Semba, Takahiro Maeda
FASEB Hematologic Malignancies Conference 2023.8
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Autophagy Induction via mTORC1 Inhibition is an Essential Mechanism in Glucocorticoid-Mediated Cell Death in B-cell Precursor Acute Lymphoblastic Leukemia Invited International conference
Imanaga H, Semba Y, Sasaki K, Setoguchi K, Yamauchi T, Terasaki T, Nakao F, Hirabayashi S, Nogami J, Akashi K, Maeda T.
FASEB Hematologic Malignancies Conference 2023.8
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Identifying novel targets for AML therapy using functional genomic tools. Invited International conference
Takahiro Maeda
BMT/HM Grand Rounds, Dana-Farber Cancer Institute. 2023.5
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Identifying novel combination therapies for B-ALL harboring the IgH::CRLF2 rearrangement using functional genomics tools Invited International conference
Takahiro Maeda
European School of Haematology ALL 2023, Berlin, Germany 2023.5
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Genome-wide CRISPR-Cas9 screens identify the GATOR1 complex as a critical regulator of glucocorticoid sensitivity in B-ALL International conference
Hiroshi Imanaga, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, Shigeki Hirabayashi, Jumpei Nogami, Koichi Akashi, and Takahiro Maeda
American Society of Hematology Annual Meeting, New Orleans, LA 2022.12
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The XPO7/NPAT axis is a potential therapeutic target for TP53-mutated AML International conference
Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Qiuming Yao, Matthew C. Canver, Luca Pinello, Daniel E. Bauer, Seishi Ogawa, Koichi Akashi and Takahiro Maeda
American Society of Hematology Annual Meeting, New Orleans, LA 2022.12
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Genome-Wide CRISPR-Cas9 Screen Identifies Rationally Designed Combination Therapies Relevant for CRLF2-Rearranged Ph-like ALL International conference
Sasaki K, Yamauchi T, Semba Y, Nogami J, Imanaga H, Terasaki T, Nakao F, Akahane K, Inukai T, Verhoeyen E, Akashi K and Maeda T
American Society of Hematology annual meeting, Atlanta, USA 2021.12
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PAICS, a de novo purine synthetic enzyme, is a novel target for AML therapy. International conference
Yamauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T.
American Society of Hematology annual meeting, Orland, USA 2019.9
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CRISPR-Cas9 screen identifies Me2, a mitochondrial malic enzyme, as a molecule relevant for MCL1 inhibitor resistance in AML. American Society of Hematology annual meeting, International conference
Nakao F, Yamauchi T, SembaY, Nogami J, Akashi K and Maeda T.
American Society of Hematology annual meeting, Orland, USA 2019.9
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CRISPR-Cas9 screen identifies XPO7 as a potential therapeutic target for TP53-mutated AML. International conference
SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
American Society of Hematology annual meeting, Orland, USA 2019.9
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A fast and accurate diagnostic method for Ph-like ALL using the nCounter system. International conference
Sasaki K, Miyawaki K, Semba Y, Kato K, Nogami J, Sugio T, Miyamoto T, Ito Y, Nagafuji K, Maeda T, Akashi K.
American Society of Hematology annual meeting, Orland, USA 2019.9
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CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML. International conference
SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
SOHO 2019 2019.9
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PAICS inhibition is a potential therapeutic strategy for MYC-positive aggressive DLBCL. International conference
Miyawaki K, Yamauchi T, SugioT, Sasaki K, Miyoshi H, Osborne S, Taylor D, Ohshima K, Kato K, Maeda T, Akashi K.
SOHO 2019 2019.9
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Genome-wide CRISPR screen identifies PAICS, and enzyme involved in de novo purine synthesis, as a potential target for AML therapy. International conference
Yamauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T.
SOHO 2019 2019.9
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PAICS inhibition is a potential therapeutic strategy for MYC-positive DLBCL. International conference
Miyawaki K, Yamauchi T, SugioT, Sasaki K, Miyoshi H, Osborne S, Taylor D, Ohshima K, Kato K, Maeda T, Akashi K.
American Society of Hematology annual meeting, Orland, USA 2019.9
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PAICS inhibition is a potential therapeutic strategy for MYC-positive aggressive DLBCL. International conference
Miyawaki K, Yamauchi T, SugioT, Sasaki K, Miyoshi H, Osborne S, Taylor D, Ohshima K, Kato K, Maeda T, Akashi K.
FASEB: The Hematologic Malignancies Conference. 2019.7
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A fast and accurate diagnostic method for Ph-like ALL using the nCounter system. International conference
Sasaki K, Miyawaki K, Semba Y, Kato K, Nogami J, Sugio T, Miyamoto T, Ito Y, Nagafuji K, Maeda T, Akashi K.
FASEB: The Hematologic Malignancies Conference. 2019.7
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CRISPR-Cas9 screen identifies Me2, a mitochondrial malic enzyme, as a molecule relevant for MCL1 inhibitor resistance. FASEB: The Hematologic Malignancies Conference. International conference
Nakao F, Yamauchi T, SembaY, Nogami J, Akashi K and Maeda T.
FASEB: The Hematologic Malignancies Conference. 2019.7
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CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML. International conference
SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
FASEB: The Hematologic Malignancies Conference. 2019.7
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Genome-wide CRISPR screen identifies PAICS, and enzyme involved in de novo purine synthesis, as a potential target for AML therapy. International conference
Yamauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T.
FASEB: The Hematologic Malignancies Conference. 2019.7
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プレシジョン血液腫瘍学：次世代シークエンスの導入が臨床現場にもたらすこと Invited
前田高宏
第80回 日本血液学会総会 2018.10
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Identifying novel targets for leukemia therapy using the CRISPR/Cas9 gene-editing tool Invited
2018.9
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全ゲノムCRISPR-Cas9スクリーニングによる白血病細胞の増殖に必要なpre-mRNA合成制御因子の同定 Invited
前田高宏
第77回日本癌学会学術総会 2018.9
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Leukemia-specific dependence on a nuclear pre-mRNA processing pathway regulated by the DCPS decapping enzyme Invited International conference
Takahiro Maeda
Novel insights into nuclear events in cancer 2018.6
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Genome-Wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Invited International conference
Takahiro Maeda
American Society of Hematology Annual Meeting 2017.12
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Genome-wide CRISPR/Cas9 screen reveals that the DCPS scavenger decapping enzyme is essential for AML cell survival
Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg V.A.C., Cole MA, Trevino CM, Ishikawa Y, Yao Qiuming, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.
American Society of Hematology Annual Meeting 2017.12
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Targeting nuclear RNA metabolic pathways for the treatment of acute myeloid leukemia
Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg V.A.C., Cole MA, Trevino CM, Ishikawa Y, Yao Qiuming, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.
Japanese Society of Hematology 2017.10
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Regulation of fetal hemoglobin expression by the LRF transcription factor Invited
Takahiro Maeda
Japanese Society of Hematology 2017.10
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Transcription factor LRF is a repressor of γ-globin expression. Invited International conference
Gamma Globin Induction Translational Mini-Workshop. Children’s Hospital Boston 2016.5
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Regulation of lympho-hematopoiesis by the transcription factor LRF/ZBTB7A Invited
Takahiro Maeda
Japanese Society of Immunology 2016.11
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Identification of novel targets for AML therapy via a genome-wide CRISPR-Cas9 screen. Invited
Takahiro Maeda
5th Cancer Stem Cell Symposium 2016.11
Professional Memberships
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Japan Society of Transfusion Medicine and Cell Therapy
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Japanese Society of Internal Medicine
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Japanese Cancer Association
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Japan Society for Hematopoietic Cell Transplantation
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Society of Hematologic Oncology
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Japanese Society of Hematology
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American Society of Hematology
Committee Memberships
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Society of Hematologic Oncology Ambassador Foreign country
2019.3 - Present
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Councilor Domestic
2016.10 - Present
Research Projects
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自己免疫疾患における加齢性クローナル造血の関連についての検討
Grant number：22K08565 2022 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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白血病難治性の分子機構解明と新規治療法の開発
Grant number：20H05699 2020 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(S)
Authorship：Principal investigator Grant type：Scientific research funding
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白血病難治性の分子機構解明と新規治療法の開発
Grant number：20H00540 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
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急性NK白血病における腫瘍微小環境解析
Grant number：20H03716 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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骨髄不全症候群における胚細胞異変および体細胞異変の解明に基づく新規治療開発
Grant number：19H01053 2019 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(A)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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急性骨髄性白血病に対する新規分化誘導療法の開発
Grant number：18cm0106135h0001 2018 - 2019
科学研究費助成事業 AMED 次世代がん医療創生研究事業
Authorship：Principal investigator Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
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Targeting the NuRD complex for fetal globin induction International coauthorship
2017.10 - 2022.9
Kyushu University (Japan)
Authorship：Principal investigator
Hemoglobinopathies, such as sickle cell disease (SCD) and thalassemia, are among the greatest public health concerns in the world. Although new therapeutic modalities, such as gene therapy, are currently being tested, there is a pressing need for pharmacologic approaches to treat general patient populations. Our long-term goal is to develop a compound(s) that induces fetal-type globin (HbF) production by targeting the transcriptional complex regulating globin switching. The objective of this application is to determine molecular mechanisms underlying the LRF-NuRD-mediated γ-globin silencing and identify a mean(s) to target them. Our central hypothesis is that the LRF-containing NuRD complex is a potential target for HbF reactivation therapy. The rationale for the proposed research is that understanding the LRF/NuRD-mediated globin regulation will provide greater understanding of the transcriptional complex regulating γ-globin repression and facilitate development of novel therapeutic strategies for HbF induction therapy.
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全ゲノム機能的CRISPRスクリーニングによる新規白血病治療標的分子
2017.4 - 2020.3
九州大学 （日本）
Authorship：Principal investigator
全ゲノムCRISPR/Cas9スクリーニングにより、新規白血病の治療標的となる分子を同定する。
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全ゲノム機能的CRISPRスクリーニングによる新規白血病治療標的分子の探索
Grant number：17H01567 2017 - 2019
日本学術振興会 科学研究費助成事業 基盤研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
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Targeting the NuRD complex for fetal globin induction
Grant number：1R01DK111455-01 2016 - 2021
Grants-in-Aid for Scientific Research
Authorship：Principal investigator Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
Class subject
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臨床医学研究コース
2023.4 - 2024.3 Full year
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臨床医学研究コース
2022.4 - 2023.3 Full year
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臨床医学研究コース
2021.4 - 2022.3 Full year
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臨床医学研究コース
2020.4 - 2021.3 Full year
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臨床医学研究コース
2019.4 - 2020.3 Full year
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臨床医学研究コース
2018.4 - 2019.3 Full year
Participation in international educational events, etc.
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2023.5
ESH
European School of Hematology ALL 2023
Venue：Germany, Berlin
Activities contributing to policy formation, academic promotion, etc.
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2023.10 - 2025.3 医薬品アクセス確保WG（DDWG）
医薬品アクセス確保WG（DDWG）
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2023.10 - 2025.3 厚生労働省 エキスパートパネル標準化WG
患者情報登録ＷＧ、造血器腫瘍サブＷＧ (RPWG)
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2023.10 - 2025.3 厚生労働省 エキスパートパネル標準化WG
二次的所見WG (SFWG)
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2023.3 - 2025.3 厚労省中釜班患者還元WG
厚労省中釜班患者還元WG
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2020.10 - 2023.3 厚生労働科学研究費補助金 がん政策研究事業
造血器腫瘍における遺伝子パネル検査の提供体制構築およびガイドライン作成 （20EA2601）
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2019.10 - 2021.3 厚生労働科学研究（がん対策推進総合研究事業）
大江班『がんゲノム医療に携わる医師等の育成に資する研究（19EA1007）』
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2019.4 - 2019.6 厚生労働省 がんゲノム医療中核拠点病院等の指定要件に関するワーキンググループ
がんゲノム医療中核拠点病院等の指定要件に関するワーキンググループ
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2018.10 - 2025.3 厚生労働省 エキスパートパネル標準化ワーキンググループ
エキスパートパネル標準化WG
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2018.4 - 2025.3 日本血液学会ゲノム医療委員会
日本血液学会ゲノム医療委員会
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Hematology
Clinician qualification
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Specialist
The Japanese Society of Hematology
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Certifying physician
The Japanese Society of Internal Medicine（JSIM）
Year of medical license acquisition
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1994