Generation of functional oocytes from male mice in vitro 査読 国際誌

Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, Nosaka Y, Ishikura Y, Kitajima TS, Semba Y, Kunisaki Y, Arai F, Akashi K, Saitou M, Kato K, Hayashi K.

Nature   2023年3月

Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation 査読 国際誌

Taniguchi S, Utsumi S, Kochi Y, Taya Y, Mori Y, Semba YI, Sugio T, Miyawaki K, Kikushige Y, Kunisaki Y, Yoshimoto G, Numata A, Kato K, Uchida N, Maeda T, Miyamoto T, Taniguchi S, Akashi K.

Int J Hematol.   2023年2月

A preterm newborn-onset juvenile myelomonocytic leukemia-like myeloproliferation with PTPN11 mutation 査読 国際誌

Yamamoto S, Nakao S, Inoue H, Koga Y, Kojima-Ishii K, Semba Y, Maeda T, Akashi K, Ohga S.

Pediatr Blood Cancer   2023年2月

Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing 査読 国際誌

Stumpf PS, Du X, Imanishi H, Kunisaki Y, Semba Y, Noble T, Smith RCG, Rose-Zerili M, West JJ, Oreffo ROC, Farrahi K, Niranjan M, Akashi K, Arai F, MacArthur BD.

Commun Biol.   2022年12月

Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model 査読 国際誌

Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E.

Gastric Cancer   2022年9月

Human acute leukemia utilizes branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function 査読 国際誌

Kikushige Y, Miyamoto T, Kochi Y, Semba Y, Ohishi M, Irifune H, Hatakeyama K, Kunisaki Y, Sugio T, Sakoda T, Miyawaki K, Kato K, Soga T, Akashi K.

Blood Adv.   2022年8月

Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions 査読 国際誌

Ito M, Nakano M, Ariyama H, Yamaguchi K, Tanaka R, Semba Y, Sugio T, Miyawaki K, Kikushige Y, Mizuno S, Isobe T, Tanoue K, Taguchi R, Ueno S, Kawano T, Murata M, Baba E, Akashi K.

Cancer Lett.   2022年4月

A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL 査読 国際誌

Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.

Blood Adv.   2022年4月

TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma 査読 国際誌

Hatakeyama K, Hieda M, Semba Y, Moriyama S, Wang Y, Maeda T, Kato K, Miyamoto T, Akashi K, Kikushige Y.

JACC CardioOncol.   2022年3月

TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells 査読 国際誌

Kawano S, Mitoma H, Inokuchi S, Yamauchi Y, Yokoyama K, Nogami J, Semba Y, Ayano M, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

J Immunol.   2022年3月

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL 査読 国際誌

Sasaki K, Yamauchi T, Semba Y, Nogami J, Imanaga H, Terasaki T, Nakao F, Akahane K, Inukai T, Verhoeyen E, Akashi K, Maeda T.

Blood   2022年2月

Targeting leukemia-specific dependence on the de novo purine synthesis pathway 査読 国際誌

Yamauchi T, Miyawaki K, Semba Y, Takahashi M, Izumi Y, Nogami J, Nakao F, Sugio T, Sasaki K, Pinello L, Bauer DE, Bamba T, Akashi K, Maeda T.

Leukemia   2022年2月

Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch 査読 国際誌

Henzan T, Yamauchi T, Yamanaka I, Sakoda T, Semba Y, Hayashi M, Kikushige Y, Mishima H, Ishimura M, Koga Y, Miyamoto T, Ohga S, Akashi K, Maeda T, Kunisaki Y.

Int J Hematol.   2021年12月

Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion 査読 国際誌

Oya S, Morishige S, Ozawa H, Sasaki K, Semba Y, Yamasaki Y, Nakamura T, Aoyama K, Seki R, Mouri F, Osaki K, Miyamoto T, Maeda T, Nagafuji K.

Int J Hematol.   2021年2月

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45- TER119-Erythroid and Lymphoid Progenitors. 査読 国際誌

Gotoh K, Kunisaki Y, Mizuguchi S, Setoyama D, Hosokawa K, Yao H, Nakashima Y, Yagi M, Uchiumi T, Semba Y, Nogami J, Akashi K, Arai F, Kang D.

iScience   2020年10月

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration 査読 国際誌

Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y.

Nat Commun.   2018年4月

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS 査読 国際誌

Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.

Cancer Cell   2018年3月

Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response 査読 国際誌

Yuda J, Miyamoto T, Odawara J, Ohkawa Y, Semba Y, Hayashi M, Miyamura K, Tanimoto M, Yamamoto K, Taniwaki M, Akashi K.

Cancer Sci.   2017年12月

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells 査読 国際誌

Semba Y, Harada A, Maehara K, Oki S, Meno C, Ueda J, Yamagata K, Suzuki A, Onimaru M, Nogami J, Okada S, Akashi K, Ohkawa Y.

Nucleic Acids Res.   2017年9月

Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 査読 国際誌

Taguchi H, Xie Y, Horikoshi N, Maehara K, Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.

Biochemistry   2017年4月

Significance of monitoring trough plasma concentration levels for invasive fungal infection prophylaxis with itraconazole oral solution in patients with hematological malignancies: a prospective study 査読 国際誌

Kawano I, Matsumoto K, Jiromaru T, Jinnochi F, Semba Y, Sugio T, Sakamoto K, Saito N, Yoshida S, Henzan H, Takase K, Morita K, Eto T.

Rinsho Ketsueki   2016年12月

Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas 査読 国際誌

Kuniyoshi Y, Maehara K, Iwasaki T, Hayashi M, Semba Y, Fujita M, Sato Y, Kimura H, Harada A, Ohkawa Y.

PLoS One   2016年10月

Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2 査読 国際誌

Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.

J Cell Biochem.   2016年3月

Generation of a monoclonal antibody for INI1/hSNF5/BAF47 査読 国際誌

Harada A, Hayashi M, Kuniyoshi Y, Semba Y, Sugahara S, Tachibana T, Ohkawa Y, Fujita M.

Monoclon Antib Immunodiagn Immunother.   2014年2月

臨床応用に向けたヒト白血病幹細胞特異的標的分子TIM-3の機能解明

2021年4月 - 2024年3月

臨床応用に向けたヒト白血病幹細胞特異的標的分子TIM-3の機能解明

研究課題/領域番号：21H04827  2021年 - 2024年

日本学術振興会  科学研究費助成事業  基盤研究(A)

白血病難治性の分子機構解明と新規治療法の開発

研究課題/領域番号：20H05699  2020年 - 2025年

日本学術振興会  科学研究費助成事業  基盤研究(S)