Updated on 2024/10/09

Information

 

写真a

 
YAMAZA TAKAYOSHI
 
Organization
Faculty of Dental Science Department of Dental Science Professor
Kyushu University Hospital (Joint Appointment)
School of Dentistry Department of Dentistry(Joint Appointment)
Graduate School of Dental Science (Joint Appointment)
Graduate School of Dental Science Department of Dental Science(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426305
Profile
1. Human stem cell-based translational research in regenerative medicine and dental medicine 2. Origin, phenotypes and kinetics of stem cells 3. Function of stem cells in bone and mineral metabolism and osteoimmunology 4. Lecture and Practice of Anatomy for dental school students 5. Lecture and Practice of Oral Anatomy for dental school students 6. Lecture and Practice of Tooth Anatomy for dental school students 7. Lecture of Human Development for dental school students 8. Lecture and Practice of Oral Histology for dental school students 9. Early exposure to undergraduate dental students 10. Research exposure to undergraduate dental students 11. Scientific instruction to graduate students 12. Scientific instruction to undergraduate students
External link

Research Areas

  • Life Science / Oral biological science

Degree

  • PhD

Research History

  • Kyushu University Professor

    2021.4 - Present

      More details

Research Interests・Research Keywords

  • Research theme:幹細胞

    Keyword:幹細胞

    Research period: 2024

  • Research theme:トランスレーショナルリサーチ

    Keyword:トランスレーショナルリサーチ

    Research period: 2024

  • Research theme:Stem Cells Translational Research

    Keyword:Stem Cells Translational Research

    Research period: 2024

  • Research theme:Origin, Characterization and Kinetics of Stem Cells

    Keyword:Stem Cells, Origin, Characterization, Kinetics

    Research period: 2009.4

  • Research theme:Functional Characterization of Stem Cells in Bone Metabolism and Osteoimmunology

    Keyword:Bone Metabolism, Osteoimmunology, Mesenchymal Stem Cells

    Research period: 2009.4

  • Research theme:Translational Research of HumanStem Cells in Regenerative Medicine

    Keyword:Regeneration in Dental Medicine, Stem Cells in Translational Research

    Research period: 2009.4

Awards

  • Best Original Article in 2010 Oral Diseases Awards

    2010.12   Oral Diseases   Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases. F Feng, K Akiyama, Y Liu, T Yamaza, T-M Wang, J-H Chen, BB Wang, G T-J Huang, S Wang, S Shi.

  • Travel award

    2003.7   1st joint meeting of the international bone and mineral society and the Japanese society for bone and mineral research  

Papers

  • NaV1.1 contributes to the cell cycle of human mesenchymal stem cells by regulating AKT and CDK2 Reviewed

    Mohammed Fouad Zakaria, Hiroki Kato, Soichiro Sonoda, Kenichi Kato, Norihisa Uehara, Yukari Kyumoto-Nakamura, Mohammed Majd Sharifa, Liting Yu, Lisha Dai, Haruyoshi Yamaza, Shunichi Kajioka, Fusanori Nishimura, Takayoshi Yamaza

    Journal of Cell Science   2024.9   ISSN:0021-9533 eISSN:1477-9137

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Company of Biologists  

    Non-excitable cells express sodium voltage-gated channel alpha subunit 1 gene and protein (SCN1A/NaV1.1); however, the functions of NaV1.1 are unclear. SCN1A was expressed in human mesenchymal stem cells (MSCs). Nav1.1 was abundantly expressed in the endoplasmic reticulum of MSCs; however, its expression was not found to be related to sodium currents. SCN1A-silencing reduced MSC proliferation and delayed the cell cycle in the S phase. SCN1A-silencing also suppressed the protein levels of CDK2 and AKT, despite similar mRNA expression, and inhibited AKT phosphorylation in MSCs. Cycloheximide-chase assay showed that SCN1A-silencing induced CDK2 but not AKT protein degradation in MSCs. Proteolysis inhibition assay using epoxomicin, bafilomycin A1, and NH4Cl, revealed that the ubiquitin-proteasome and autophagy/endo-lysosome systems were irrelevant to CDK2 and AKT protein reduction in SCN1A-silenced MSCs. AKT inhibitor LY294002 did not affect the degradation and nuclear localization of CDK2 in MSCs. Likewise, AKT activator SC79 did not attenuate the SCN1A-silencing effects on CDK2 in MSCs. These results suggest that NaV1.1 contributes to the cell cycle of MSCs by regulating the post-translational control of AKT and CDK2.

    DOI: 10.1242/jcs.261732

    PubMed

    researchmap

  • Dental pulp stem cells as a therapy for congenital entero-neuropathy Invited Reviewed International journal

    Dental pulp stem cells as a therapy for congenital entero-neuropathy Yoshimaru, K., Yamaza, T., Kajioka, S., Sonoda, S., Yanagi, Y., Matsuura, T., Yoshizumi, J., Oda, Y., Iwata, N., Takai, C., Nakayama, S. & Taguchi, T.

    Scientific Reports   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells Reviewed International coauthorship

    Ratih Yuniarthe, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Stem Cell Research and Therapy   12 ( 1 )   2020.1

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-020-02113-8.

  • Potential role of stem cells from human exfoliated deciduous teeth in inducing liver regeneration Reviewed International coauthorship

    Alatas, FS; Yamaza, T; Matsuura, T; Ongko, L; Kadim, M; Ohga, S; Taguchi, T; Tajiri, T

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2024.6   ISSN:0815-9319 eISSN:1440-1746

     More details

    Language:English   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    Background and Aim: Even with advancement of medical technologies, liver transplantation still faces several major challenges. Hence, other treatment modalities are urgently needed for patients with end-stage liver disease. Stem cells from human exfoliated deciduous teeth (SHED) was discovered to have highly proliferative and pluripotent properties; including differentiation into hepatocyte-like cells. This study aims to investigate the capability of intrasplenic transplanted SHED and SHED-Hep cells in inducing proliferation of stem cells and native hepatocytes in order to accelerate liver regeneration in liver fibrosis mice models. Methods: Three carbon tetrachloride (CCl4)-injured male mice groups were used in this study. Two of those groups were transplanted with either SHED or SHED-Hep, while the other did not undergo transplantation. One age- and sex- matched healthy mice group was used as control. All specimens were immunohistochemically stained with anti-Ki-67 antibodies and anti-proliferating cell nuclear antigen (PCNA) antibodies before counter stained with hematoxylin–eosin. Results: Anti-Ki-67 antibodies staining: at both 8 and 12 weeks, proliferating activity was predominantly seen on both SHED- and SHED-Hep-transplanted CCl4-injured mice groups, while control and non-transplanted CCl4-injured mice group showed little to no sign of proliferation activity. Anti-PCNA staining: at both 8 and 12 weeks, significant proliferating activity was detected by PCNA staining, mainly on stem cells population area on SHED- and SHED-Hep-treated group. Conclusions: In conclusion, this study has provided the evidence that transplantation of SHED or SHED-Hep on liver-injured mice induced proliferation of both transplanted stem cells and native liver cells in order to accelerate liver regeneration.

    DOI: 10.1111/jgh.16651

    Web of Science

    Scopus

    PubMed

  • Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease Reviewed International coauthorship

    Zakaria MHD. Fouad, Sonoda Soichiro, Kato Hiroki, Ma Lan, Uehara Norihisa, Kyumoto Yukari, Sharifa M. Majd, Yu Liting, Dai Lisha, Yamauchi Erika, Aijima Reona, Yamaza Haruyoshi, Nishimura Fusanori, Yamaza Takayoshi

    Scientific Reports   14   6719   2024.3   eISSN:20452322

     More details

    Authorship:Last author, Corresponding author   Language:English  

    Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.

    CiNii Research

  • Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. Reviewed International coauthorship International journal

    Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza

    Scientific reports   14 ( 1 )   6719 - 6719   2024.3   ISSN:2045-2322

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.

    DOI: 10.1038/s41598-024-57361-y

    Web of Science

    Scopus

    PubMed

    researchmap

  • Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Reviewed

    Norihisa Uehara, Shibusawa N, Mikami Y, Kyumoto-Nakamura Y, Sonoda S, Kato H, Yamaza T, Kukita T

    Archives of biochemistry and biophysics   750   109821   2023.11   ISSN:0003-9861 eISSN:1096-0384

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    The metastases of breast cancer to bone often cause osteolytic lesions not only by stimulating osteoclasts to resorb the bone but also by inhibiting osteoblasts from bone formation. Although tumor cell-derived extracellular vesicles (EVs) promote osteoclast differentiation and bone resorption, their roles in osteoblast differentiation and functions have not been elucidated. In this study, we investigated the effects of breast cancer cell-derived EVs on osteoblast differentiation and functions in vitro. We found that upon osteogenic induction, 4T1 bone metastatic mouse mammary tumor cell-derived EVs (4T1-EVs) were inhibited matrix mineralization of ST2 mouse bone marrow stromal cells. Temporal expression analysis of osteoblast marker genes, including runt-related transcription factor 2 (Runx2), osterix (Osx), alkaline phosphatase (Alp), collagen type I (Col1a1), bone sialoprotein (Bsp), and osteocalcin (Bglap) revealed that 4T1-EVs decreased their expression during the late stage of osteoblast differentiation. Elevated levels of c-Jun N-terminal kinase (JNK) phosphorylation, upon osteogenic induction, were diminished by 4T1-EVs, significantly. In contrast, the nullification of reduced JNK phosphorylation by anisomycin, a potent JNK activator, increased the expression levels of osteoblast differentiation markers. Overall, our data indicated that 4T1-EVs affect osteoblast maturation, at least partially, through the regulation of JNK activity, which provides novel insights into the pathological impact of osteolytic bone metastasis and the role of EVs in osteoblast differentiation.

    DOI: 10.1016/j.abb.2023.109821

    Web of Science

    Scopus

    PubMed

    researchmap

  • Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders. Reviewed

    Koichiro Yoshimaru, Toshiharu Matsuura, Yasuyuki Uchida, Soichiro Sonoda, Shohei Maeda, Keisuke Kajihara, Yuki Kawano, Takeshi Shirai, Yukihiro Toriigahara, Alvin Santoso Kalim, Xiu-Ying Zhang, Yoshiaki Takahashi, Naonori Kawakubo, Kouji Nagata, Haruyoshi Yamaza, Takayoshi Yamaza, Tomoaki Taguchi, Tatsuro Tajiri

    Surgery today   54 ( 9 )   977 - 994   2023.9   ISSN:0941-1291 eISSN:1436-2813

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy. Notably, HSCR involving the small intestine, isolated hypoganglionosis, chronic idiopathic intestinal pseudo-obstruction, and megacystis-microcolon-intestinal hypoperistalsis syndrome carry a poor prognosis. Ultimately, small-bowel transplantation (SBTx) is necessary for refractory cases, but it is highly invasive and outcomes are less than optimal, despite advances in surgical techniques and management. Thus, regenerative therapy has come to light as a potential form of treatment involving regeneration of the enteric nervous system, mesenchyme, and smooth muscle in affected areas. We review the cutting-edge regenerative therapeutic approaches for managing HSCR and AD-HSCR, including the use of enteric nervous system progenitor cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells as cell sources, the recipient intestine's microenvironment, and transplantation methods. Perspectives on the future of these treatments are also discussed.

    DOI: 10.1007/s00595-023-02741-6

    Web of Science

    Scopus

    PubMed

    researchmap

  • Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells Reviewed

    TAKAHASHI Ryosuke, ATSUTA Ikiru, NARIMATSU Ikue, YAMAZA Takayoshi, ZHANG Xiaoxu, EGASHIRA Yuki, KOYANO Kiyoshi, AYUKAWA Yasunori

    Dental Materials Journal   42 ( 2 )   282 - 290   2023.3   ISSN:02874547 eISSN:18811361

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society for Dental Materials and Devices  

    <p>Carbonate apatite (CO<sub>3</sub>Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO<sub>3</sub>Ap, we compared differences among CO<sub>3</sub>Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For <i>in vivo</i> experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO<sub>3</sub>Ap and β-TCP groups. For <i>in vitro</i> experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO<sub>3</sub>Ap and HAp groups than in the β-TCP group. Increases in insulin-like growth factor-I and vascular endothelial growth factor were found only in the CO<sub>3</sub>Ap group. CO<sub>3</sub>Ap-filled extraction sockets accumulated MSCs, and MSCs cultured in the presence of CO<sub>3</sub>Ap produced large amounts of growth factors. These results suggest that CO<sub>3</sub>Ap promotes healing of tooth extraction sockets.</p>

    DOI: 10.4012/dmj.2022-040

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

  • Extracellular vesicles rejuvenate the microenvironmental modulating function of recipient tissue-specific mesenchymal stem cells in osteopenia treatment. Invited Reviewed International journal

    Soichiro Sonoda, Takayoshi Yamaza

    Frontiers in endocrinology   14   1151429 - 1151429   2023.3   ISSN:1664-2392

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    Systemic transplantation of mesenchymal stem cells (MSCs), such as bone marrow MSCs (BMMSCs) and stem cells from human exfoliated deciduous teeth (SHED), is considered a prominent treatment for osteopenia. However, the mechanism of action of the transplanted MSCs has been poorly elucidated. In the recipient target tissue, including bone and bone marrow, only a few donor MSCs can be detected, suggesting that the direct contribution of donor MSCs may not be expected for osteopenia treatment. Meanwhile, secretomes, especially contents within extracellular vesicles (EVs) released from donor MSCs (MSC-EVs), play key roles in the treatment of several diseases. In this context, administrated donor MSC-EVs may affect bone-forming function of recipient cells. In this review, we discuss how MSC-EVs contribute to bone recovery recipient tissue in osteopenia. We also summarize a novel mechanism of action of systemic administration of SHED-derived EVs (SHED-EVs) in osteopenia. We found that reduced telomerase activity in recipient BMMSCs caused the deficiency of microenvironmental modulating function, including bone and bone marrow-like niche formation and immunomodulation in estrogen-deficient osteopenia model mice. Systemic administration of SHED-EVs could exert therapeutic effects on bone reduction via recovering the telomerase activity, leading to the rejuvenation of the microenvironmental modulating function in recipient BMMSCs, as seen in systemic transplantation of SHED. RNase-preconditioned donor SHED-EVs diminished the therapeutic benefits of administrated SHED-EVs in the recipient osteopenia model mice. These facts suggest that MSC-EV therapy targets the recipient BMMSCs to rejuvenate the microenvironmental modulating function via telomerase activity, recovering bone density. We then introduce future challenges to develop the reproducible MSC-EV therapy in osteopenia.

    DOI: 10.3389/fendo.2023.1151429

    Web of Science

    Scopus

    PubMed

    researchmap

  • 間葉系幹細胞に関する視点からの評価した、ラット抜歯窩への骨補填材としての炭酸アパタイト(Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells) Reviewed

    Takahashi Ryosuke, Atsuta Ikiru, Narimatsu Ikue, Yamaza Takayoshi, Zhang Xiaoxu, Egashira Yuki, Koyano Kiyoshi, Ayukawa Yasunori

    Dental Materials Journal   42 ( 2 )   282 - 290   2023.3   ISSN:0287-4547

     More details

    Language:English   Publisher:(一社)日本歯科理工学会  

    骨補填材としての炭酸アパタイト(炭酸Ap)をハイドロキシアパタイト(HAp)およびβリン酸三カルシウム(β-TCP)と比較し、間葉系幹細胞(MSC)に注目してそれらの間にみられる差異を検討した。6週齢の雄性ラット30匹を使用してin vivo実験を施行した。上顎の第1・2大臼歯を抜歯し、抜歯窩に上記3種の骨補填材のいずれかを移植した。その3日後と7日後に深麻酔死させ各種の評価に供した。その結果、炭酸Ap群とβ-TCP群では、抜歯窩付近のMSCの集積が有意に促進された。MSCを骨補填材の存在下で培養するin vitro実験も行ったところ、炭酸Ap群とHAp群では分化能とカルシウム沈着量がβ-TCP群よりも有意に低減していた。インスリン様成長因子I(IGF-I)と血管内皮細胞増殖因子(VEGF)が増加しているという結果は炭酸Ap群のみで認められた。炭酸Apを充填した抜歯窩にはMSCが集積し、炭酸Ap存在下で培養したMSCは成長因子類を大量に産生したことから、炭酸Apは抜歯窩の治癒を促進することが示唆された。

  • Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice Reviewed

    Murayama, M; Hirata, H; Shiraki, M; Iovanna, JL; Yamaza, T; Kukita, T; Komori, T; Moriishi, T; Ueno, M; Morimoto, T; Mawatari, M; Kukita, A

    JOURNAL OF CELLULAR PHYSIOLOGY   238 ( 3 )   566 - 581   2023.3   ISSN:0021-9541 eISSN:1097-4652

     More details

    Language:English   Publisher:Journal of Cellular Physiology  

    Nuclear protein 1 (NUPR1) is a stress-induced protein activated by various stresses, such as inflammation and oxidative stress. We previously reported that Nupr1 deficiency increased bone volume by enhancing bone formation in 11-week-old mice. Analysis of differentially expressed genes between wild-type (WT) and Nupr1-knockout (Nupr1-KO) osteocytes revealed that high temperature requirement A 1 (HTRA1), a serine protease implicated in osteogenesis and transforming growth factor-β signaling was markedly downregulated in Nupr1-KO osteocytes. Nupr1 deficiency also markedly reduced HtrA1 expression, but enhanced SMAD1 signaling in in vitro-cultured primary osteoblasts. In contrast, Nupr1 overexpression enhanced HtrA1 expression in osteoblasts, suggesting that Nupr1 regulates HtrA1 expression, thereby suppressing osteoblastogenesis. Since HtrA1 is also involved in cellular senescence and age-related diseases, we analyzed aging-related bone loss in Nupr1-KO mice. Significant spine trabecular bone loss was noted in WT male and female mice during 6−19 months of age, whereas aging-related trabecular bone loss was attenuated, especially in Nupr1-KO male mice. Moreover, cellular senescence-related markers were upregulated in the osteocytes of 6−19-month-old WT male mice but markedly downregulated in the osteocytes of 19-month-old Nupr1-KO male mice. Oxidative stress-induced cellular senescence stimulated Nupr1 and HtrA1 expression in in vitro-cultured primary osteoblasts, and Nupr1 overexpression enhanced p16ink4a expression in osteoblasts. Finally, NUPR1 expression in osteocytes isolated from the bones of patients with osteoarthritis was correlated with age. Collectively, these results indicate that Nupr1 regulates HtrA1-mediated osteoblast differentiation and senescence. Our findings unveil a novel Nupr1/HtrA1 axis, which may play pivotal roles in bone formation and age-related bone loss.

    DOI: 10.1002/jcp.30949

    Web of Science

    Scopus

    PubMed

  • The challenge for the radical therapy against interstitial cystitis transplanting deciduous dental pulp stem cells Reviewed

    Kajioka, S; Kareman, E; Okabe, A; Lee, K; Yamaza, T; Etoh, M

    EUROPEAN UROLOGY   83   2023.2   ISSN:0302-2838 eISSN:1873-7560

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

    Web of Science

  • Targeting hepatic oxidative stress rescues bone loss in liver fibrosis Reviewed International coauthorship

    Soichiro Sonoda, Sara Murata, Haruyoshi Yamaza, Ratih Yuniartha, Junko Fujiyoshi, Koichiro Yoshimaru, Toshiharu Matsuura, Yoshinao Oda, Shouichi Ohga, Tasturo Tajiri, Tomoaki Taguchi, Takayoshi Yamaza

    Molecular Metabolism   66   101599   2022.12   ISSN:2212-8778 eISSN:2212-8778

     More details

    Authorship:Last author, Corresponding author   Language:Others   Publishing type:Research paper (scientific journal)  

    Objective: Chronic liver diseases often involve metabolic damage to the skeletal system. The underlying mechanism of bone loss in chronic liver diseases remains unclear, and appropriate therapeutic options, except for orthotopic liver transplantation, have proved insufficient for these patients. This study aimed to investigate the efficacy and mechanism of transplantation of immature hepatocyte-like cells converted from stem cells from human exfoliated deciduous teeth (SHED-Heps) in bone loss of chronic liver fibrosis. Methods: Mice that were chronically treated with CCl4 received SHED-Heps, and trabecular bone density, reactive oxygen species (ROS), and osteoclast activity were subsequently analyzed in vivo and in vitro. The effects of stanniocalcin 1 (STC1) knockdown in SHED-Heps were also evaluated in chronically CCl4 treated mice. Results: SHED-Hep transplantation (SHED-HepTx) improved trabecular bone loss and liver fibrosis in chronic CCl4-treated mice. SHED-HepTx reduced hepatic ROS production and interleukin 17 (Il-17) expression under chronic CCl4 damage. SHED-HepTx reduced the expression of both Il-17 and tumor necrosis factor receptor superfamily 11A (Tnfrsf11a) and ameliorated the imbalance of osteoclast and osteoblast activities in the bone marrow of CCl4-treated mice. Functional knockdown of STC1 in SHED-Heps attenuated the benefit of SHED-HepTx including anti-bone loss effect by suppressing osteoclast differentiation through TNFSF11–TNFRSF11A signaling and enhancing osteoblast differentiation in the bone marrow, as well as anti-fibrotic and anti-ROS effects in the CCl4-injured livers. Conclusions: These findings suggest that targeting hepatic ROS provides a novel approach to treat bone loss resulting from chronic liver diseases.

    DOI: 10.1016/j.molmet.2022.101599

    Web of Science

    Scopus

    PubMed

    researchmap

  • miR-92a-3p encapsulated in bone metastatic mammary tumor cell–derived extracellular vesicles modulates mature osteoclast longevity Reviewed

    Norihisa Uehara, Yukari Kyumoto-Nakamura, Yoshikazu Mikami, Manabu Hayatsu, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita

    Cancer Science   113 ( 12 )   4219 - 4229   2022.12   ISSN:1347-9032 eISSN:1349-7006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Aberrant osteoclast formation and activation are the hallmarks of osteolytic metastasis. Extracellular vesicles (EVs), released from bone metastatic tumor cells, play a pivotal role in the progression of osteolytic lesions. However, the mechanisms through which tumor cell–derived EVs regulate osteoclast differentiation and function have not been fully elucidated. In this study, we found that 4T1 bone metastatic mouse mammary tumor cell–derived EVs (4T1-EVs) are taken up by mouse bone marrow macrophages to facilitate osteoclastogenesis. Furthermore, treatment of mature osteoclasts with 4T1-EVs promoted bone resorption, which was accompanied by enhanced survival of mature osteoclasts through the negative regulation of caspase-3. By comparing the miRNA content in 4T1-EVs with that in 67NR nonmetastatic mouse mammary tumor cell–derived EVs (67NR-EVs), miR-92a-3p was identified as one of the most enriched miRNAs in 4T1-EVs, and its transfer into mature osteoclasts significantly reduced apoptosis. Bioinformatic and Western blot analyses revealed that miR-92a-3p directly targeted phosphatase and tensin homolog (PTEN) in mature osteoclasts, resulting in increased levels of phospho-Akt. Our findings provide novel insights into the EV-mediated regulation of osteoclast survival through the transfer of miR-92a-3p, which enhances mature osteoclast survival via the Akt survival signaling pathway, thus promoting bone resorption.

    DOI: 10.1111/cas.15557

    Web of Science

    Scopus

    PubMed

    researchmap

  • 骨転移乳癌細胞由来細胞外小胞に封入されたmiR-92a-3pは成熟破骨細胞の寿命を調節する(miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity) Reviewed

    Uehara Norihisa, Kyumoto-Nakamura Yukari, Mikami Yoshikazu, Hayatsu Manabu, Sonoda Soichiro, Yamaza Takayoshi, Kukita Akiko, Kukita Toshio

    Cancer Science   113 ( 12 )   4219 - 4229   2022.12   ISSN:1347-9032

     More details

    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    骨転移乳癌細胞由来細胞外小胞(EV)が破骨細胞の分化や機能に及ぼす影響とそのメカニズムについて検討した。マウス乳癌細胞株4T1由来EV(4T1-EV)がマウス骨髄マクロファージに取り込まれ、破骨細胞形成を促進することを見出した。成熟破骨細胞を4T1-EVで処理すると、骨吸収が促進され、カスパーゼ3を負に制御して成熟破骨細胞の生存が促進された。4T1-EVと非転移性マウス乳癌細胞株67NR由来EV(67NR-EV)におけるmiRNAの内容を比較した。その結果、miR-92a-3pが4T1-EVに最も濃縮されたmiRNAの一つとして特定され、miR-92a-3pの成熟破骨細胞への移入によりアポトーシスが著しく抑制された。さらに、miR-92a-3pは成熟破骨細胞においてphosphatase and tensin homolog(PTEN)を直接標的とし、リン酸化Aktのレベルを増加させた。以上より、マウス乳癌細胞株4T1由来EVに存在するmiR-92a-3pは、Akt生存シグナル経路を介して成熟破骨細胞の生存を高め、骨吸収を促進させることが示された。

  • Protocol to generate xenogeneic-free/serum-free human dental pulp stem cells. Reviewed International journal

    Soichiro Sonoda, Haruyoshi Yamaza, Koichiro Yoshimaru, Tomoaki Taguchi, Takayoshi Yamaza

    STAR protocols   3 ( 2 )   101386 - 101386   2022.6   ISSN:2666-1667

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Human dental pulp stem cell (hDPSCs)-based therapy is a feasible option for regenerative medicine, such as dental pulp regeneration. Here, we show the steps needed to colony-forming unit-fibroblasts (CFU-F)-based isolation, expansion, and cryopreservation of hDPSCs for manufacturing clinical-grade products under a xenogeneic-free/serum-free condition. We also demonstrate the characterization of hDPSCs by CFU-F, flow cytometric, and in vitro multipotent assays. For complete details on the use and execution of this protocol, please refer to Iwanaka et al. (2020).

    DOI: 10.1016/j.xpro.2022.101386

    Web of Science

    Scopus

    PubMed

    researchmap

  • Dental pulp stem cells as a therapy for congenital entero-neuropathy. Reviewed International journal

    Koichiro Yoshimaru, Takayoshi Yamaza, Shunichi Kajioka, Soichiro Sonoda, Yusuke Yanagi, Toshiharu Matsuura, Junko Yoshizumi, Yoshinao Oda, Naoko Iwata, Chiho Takai, Shinsuke Nakayama, Tomoaki Taguchi

    Scientific reports   12 ( 1 )   6990 - 6990   2022.4   ISSN:2045-2322

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Hirschsprung's disease is a congenital entero-neuropathy that causes chronic constipation and intestinal obstruction. New treatments for entero-neuropathy are needed because current surgical strategies have limitations5. Entero-neuropathy results from enteric nervous system dysfunction due to incomplete colonization of the distal intestine by neural crest-derived cells. Impaired cooperation between the enteric nervous system and intestinal pacemaker cells may also contribute to entero-neuropathy. Stem cell therapy to repair these multiple defects represents a novel treatment approach. Dental pulp stem cells derived from deciduous teeth (dDPSCs) are multipotent cranial neural crest-derived cells, but it remains unknown whether dDPSCs have potential as a new therapy for entero-neuropathy. Here we show that intravenous transplantation of dDPSCs into the Japanese Fancy-1 mouse, an established model of hypoganglionosis and entero-neuropathy, improves large intestinal structure and function and prolongs survival. Intravenously injected dDPSCs migrate to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Transplanted dDPSCs differentiate into both pacemaker cells and enteric neurons in the proximal colon to improve electrical and peristaltic activity, in addition to their paracrine effects. Our findings indicate that transplanted dDPSCs can differentiate into different cell types to correct entero-neuropathy-associated defects.

    DOI: 10.1038/s41598-022-10077-3

    Web of Science

    Scopus

    PubMed

    researchmap

  • A New Target of Dental Pulp-Derived Stem Cell-Based Therapy on Recipient Bone Marrow Niche in Systemic Lupus Erythematosus. Reviewed International journal

    Soichiro Sonoda, Takayoshi Yamaza

    International journal of molecular sciences   23 ( 7 )   2022.3   ISSN:16616596 eISSN:1422-0067

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Recent advances in mesenchymal stem/stromal cell (MSC) research have led us to consider the feasibility of MSC-based therapy for various diseases. Human dental pulp-derived MSCs (hDPSCs) have been identified in the dental pulp tissue of deciduous and permanent teeth, and they exhibit properties with self-renewal and in vitro multipotency. Interestingly, hDPSCs exhibit superior immunosuppressive functions toward immune cells, especially T lymphocytes, both in vitro and in vivo. Recently, hDPSCs have been shown to have potent immunomodulatory functions in treating systemic lupus erythematosus (SLE) in the SLE MRL/lpr mouse model. However, the mechanisms underlying the immunosuppressive efficacy of hDPSCs remain unknown. This review aims to introduce a new target of hDPSC-based therapy on the recipient niche function in SLE.

    DOI: 10.3390/ijms23073479

    Web of Science

    Scopus

    PubMed

    researchmap

  • In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion. Reviewed International journal

    Jing-Qi Zhang, Akira Takahashi, Jiong-Yan Gu, Xiaoxu Zhang, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Hidenobu Hiura, Takayoshi Yamaza, Toshio Kukita

    Laboratory investigation; a journal of technical methods and pathology   101 ( 12 )   1571 - 1584   2021.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-021-00656-9

  • Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway Invited Reviewed International journal

    Gao, Jing; Muroya, Ryusuke; Huang, Fei; Nagata, Kengo; Shin, Masashi; Nagano, Ryoko; Tajiri, Yudai; Fujii, Shinsuke; Yamaza, Takayoshi; Aoki, Kazuhiro; Tamura, Yukihiko; Inoue, Mayuko; Chishaki, Sakura; Kukita, Toshio; Okabe, Koji; Matsuda, Miho; Mori, Yoshihide; Kiyoshima, Tamotsu; Jimi, Eijiro

    LABORATORY INVESTIGATION   101 ( 11 )   1475 - 1483   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-021-00661-y

  • Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway. Reviewed International journal

    Jing Gao, Ryusuke Muroya, Fei Huang, Kengo Nagata, Masashi Shin, Ryoko Nagano, Yudai Tajiri, Shinsuke Fujii, Takayoshi Yamaza, Kazuhiro Aoki, Yukihiko Tamura, Mayuko Inoue, Sakura Chishaki, Toshio Kukita, Koji Okabe, Miho Matsuda, Yoshihide Mori, Tamotsu Kiyoshima, Eijiro Jimi

    Laboratory investigation; a journal of technical methods and pathology   101 ( 11 )   1475 - 1483   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-021-00661-y

  • Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency. Reviewed International coauthorship International journal

    Soichiro Sonoda, Koichiro Yoshimaru, Haruyoshi Yamaza, Ratih Yuniartha, Toshiharu Matsuura, Erika Yamauchi-Tomoda, Sara Murata, Kento Nishida, Yoshinao Oda, Shouichi Ohga, Tasturo Tajiri, Tomoaki Taguchi, Takayoshi Yamaza

    Stem cell research & therapy   12 ( 1 )   582 - 582   2021.11

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-021-02652-8

    Repository Public URL: https://hdl.handle.net/2324/7172586

  • Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice Invited Reviewed International coauthorship International journal

    Haruyama N, @Yamaza T, Suzuki S, Hall B, Cho A, Gibson CW, Kulkarni AB

    PLoS ONE   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1371/journal.pone.0259966

  • Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division Invited Reviewed International journal

    Kukita, Toshio; Hiura, Hidenobu; Gu, Jiong-Yan; Zhang, Jing-Qi; Kyumoto-Nakamura, Yukari; Uehara, Norihisa; Murata, Sara; Sonoda, Soichiro; Yamaza, Takayoshi; Takahashi, Ichiro; Kukita, Akiko

    LABORATORY INVESTIGATION   101 ( 11 )   1449 - 1457   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-021-00633-2

  • Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division Reviewed International journal

    Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Jing-Qi Zhang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, Akiko Kukita

    Laboratory Investigation   101 ( 11 )   1449 - 1457   2021.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-021-00633-2

  • 骨芽細胞特異的な骨改造制膜表面分子の同定 アルカリ微小環境による石灰化制御の可能性について Reviewed

    日浦 秀暢, 久本 由香里, 顧 炯炎, 張 旌旗, 上原 範久, 山座 孝義, 久木田 明子, 高橋 一郎, 久木田 敏夫

    日本骨代謝学会学術集会プログラム抄録集   39回   134 - 134   2021.10

     More details

    Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

  • Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus. Reviewed International journal

    Soichiro Sonoda, Sara Murata, Hiroki Kato, Fouad Zakaria, Yukari Kyumoto-Nakamura, Norihisa Uehara, Haruyoshi Yamaza, Toshio Kukita, Takayoshi Yamaza

    Journal of immunology (Baltimore, Md. : 1950)   206 ( 12 )   3053 - 3063   2021.6

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.2001312

  • Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Reviewed International coauthorship International journal

    Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Stem cell research & therapy   12 ( 1 )   57 - 57   2021.1

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-020-02113-8

  • 破骨細胞機能制御に関連する新規破骨細胞特異的膜表面抗原 Reviewed

    顧 炯炎, 久本 由香里, 寺町 順平, 日浦 秀暢, 張 旌旗, 張 暁旭, 上原 範久, 山座 孝義, 久木田 明子, 久木田 敏夫

    2020   205 - 205   2020.9

     More details

    Language:Japanese  

  • 骨芽細胞特異的な骨改造制御膜表面分子の同定と機能解析 Reviewed

    日浦 秀暢, 久本 由香里, 上原 範久, 張 旌旗, 顧 炯炎, 山座 孝義, 久木田 明子, 高橋 一郎, 久木田 敏夫

    2020   201 - 201   2020.9

     More details

    Language:Japanese  

  • Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Reviewed International journal

    Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

    Stem Cell Research and Therapy   11 ( 1 )   296 - 296   2020.7

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-020-01818-0

  • A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment Reviewed International journal

    Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda, Tomoaki Taguchi

    Stem Cell Research and Therapy   11 ( 1 )   134 - 134   2020.3

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-020-01630-w

  • Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A. International journal

    Yoshiaki Takahashi, Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Haruyoshi Yamaza, Kosuke Kirino, Koichiro Yoshimaru, Toshiharu Matsuura, Tomoaki Taguchi

    Pediatric surgery international   35 ( 12 )   1379 - 1388   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-019-04564-4

  • Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A Reviewed

    Yoshiaki Takahashi, Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Haruyoshi Yamaza, Kosuke Kirino, Koichiro Yoshimaru, Toshiharu Matsuura, Tomoaki Taguchi

    Pediatric surgery international   35 ( 12 )   1379 - 1388   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-019-04564-4

  • Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson’s disease Reviewed

    9 ( 1 )   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Wilson’s disease (WD) is an inherited metabolic disease arising from ATPase copper transporting beta gene (ATP7B) mutation. Orthotoropic liver transplantation is the only radical treatment of fulminant WD, although appropriate donors are lacking at the onset of emergency. Given the hepatogenic capacity and tissue-integration/reconstruction ability in the liver of stem cells from human exfoliated deciduous teeth (SHED), SHED have been proposed as a source for curing liver diseases. We hypothesized the therapeutic potential of SHED and SHED-converted hepatocyte-like- cells (SHED-Heps) for fulminant WD. SHED and SHED-Heps were transplanted into WD model Atp7b-mutated Long-Evans Cinnamon (LEC) rats received copper overloading to induce a lethal fulminant liver failure. Due to the superior copper tolerance via ATP7B, SHED-Hep transplantation gave more prolonged life-span of fulminant LEC rats than SHED transplantation. The integrated ATP7B-expressing SHED-Heps showed more therapeutic effects on to restoring the hepatic dysfunction and tissue damages in the recipient liver than the integrated naïve SHED without ATP7B expression. Moreover, SHED-Heps could reduce copper-induced oxidative stress via ATP7B- independent stanniocalcin 1 secretion in the fulminant LEC rats, suggesting a possible role for paracrine effect of the integrated SHED-Heps. Taken together, SHED-Heps offer a potential of functional restoring, bridging, and preventive approaches for treating fulminant WD.

    DOI: 10.1038/s41598-018-38275-y

  • Novel application method for mesenchymal stem cell therapy utilizing its attractant-responsive accumulation property

    Nobuyuki Ueda, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ikue Narimatsu, Yuri Matsuura, Ryosuke Kondo, Yu Watanabe, Xiaoxu Zhang, Kiyoshi Koyano

    Applied Sciences (Switzerland)   9 ( 22 )   2019.11

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/app9224908

  • Novel application method for mesenchymal stem cell therapy utilizing its attractant-responsive accumulation property Reviewed

    Nobuyuki Ueda, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ikue Narimatsu, Yuri Matsuura, Ryosuke Kondo, Yu Watanabe, Xiaoxu Zhang, Kiyoshi Koyano

    Applied Sciences (Switzerland)   9 ( 22 )   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/app9224908

  • Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling International journal

    Tamer Badawy, Yukari Kyumoto-Nakamura, Norihisa Uehara, Jingqi Zhang, Soichiro Sonoda, Hidenobu Hiura, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita

    Laboratory Investigation   99 ( 6 )   866 - 884   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-018-0179-4

  • Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling Reviewed

    Tamer Badawy, Yukari Kyumoto-Nakamura, Norihisa Uehara, Jingqi Zhang, Soichiro Sonoda, Hidenobu Hiura, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita

    Laboratory Investigation   99 ( 6 )   866 - 884   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-018-0179-4

  • Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla International journal

    Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

    Journal of Endodontics   45 ( 5 )   591 - 598.e6   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joen.2019.01.016

  • Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla Reviewed

    Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

    Journal of Endodontics   45 ( 5 )   591 - 598.e6   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joen.2019.01.016

  • Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED) a promising new treatment in pediatric surgery Reviewed

    Tomoaki Taguchi, Yusuke Yanagi, Koichiro Yoshimaru, Xiu Ying Zhang, Toshiharu Matsuura, Koichi Nakayama, Eiji Kobayashi, Haruyoshi Yamaza, Kazuaki Nonaka, Shouichi Ohga, Takayoshi Yamaza

    Surgery today   49 ( 4 )   316 - 322   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-019-01783-z

  • Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery. Reviewed

    Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, Kobayashi E, Yamaza H, Nonaka K, Ohga S, Yamaza T

    Surgery today   49 ( 4 )   316 - 322   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery.
    Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.

    DOI: 10.1007/s00595-019-01783-z

  • Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells Reviewed

    Soichiro Sonoda, Yu Feng Mei, Ikiru Atsuta, Atsushi Danjo, Haruyoshi Yamaza, Shion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza

    Scientific reports   8 ( 1 )   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-21183-6

  • Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla. Reviewed International journal

    Tanaka Y, Sonoda S, Yamaza H, Murata S, Nishida K, Hama S, Kyumoto-Nakamura Y, Uehara N, Nonaka K, Kukita T, Yamaza T

    Stem cell research & therapy   9 ( 1 )   334 - 334   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla.
    BACKGROUND: Stem cells from apical papilla (SCAP) are a subpopulation of mesenchymal stem cells (MSCs) isolated from the apical papilla of the developing tooth root apex of human teeth. Because of their osteogenic/dentinogenic capacity, SCAP are considered as a source for bone and dentin regeneration. However, little is understood about the molecular mechanism of osteogenic/dentinogenic differentiation of SCAP. Phosphoinositide 3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signal pathway participates in regulating the differentiation of various cell types, such as MSCs. In this study, we examined the role of the PI3K-AKT-mTOR signal pathway in the osteogenic/dentinogenic differentiation of SCAP. Moreover, we challenge to fabricate scaffold-free SCAP-based spheroidal calcified constructs. METHODS: SCAP were pretreated with or without small interfering RNA for AKT (AKT siRNA), PI3K inhibitor LY294402, and mTOR inhibitor rapamycin and were cultured under osteogenic/dentinogenic differentiation to examine in vitro and in vivo calcified tissue formation. Moreover, SCAP-based cell aggregates were pretreated with or without LY294402 and rapamycin. The cell aggregates were cultured under osteogenic/dentinogenic condition and were analyzed the calcification of the aggregates. RESULTS: Pretreatment with AKT siRNA, LY294402, and rapamycin enhances the in vitro and in vivo calcified tissue-forming capacity of SCAP. SCAP were fabricated as scaffold-free spheroids and were induced into forming calcified 3D constructs. The calcified density of the spheroidal constructs was enhanced when the spheroids were pretreated with LY294402 and rapamycin. CONCLUSIONS: Our findings indicate that the suppression of PI3K-AKT-mTOR signal pathway plays a role in not only enhancing the in vivo and in vitro osteogenic/dentinogenic differentiation of SCAP, but also promoting the calcification of scaffold-free SCAP-based calcified constructs. These findings suggest that a suppressive regulation of PI3K-AKT-mTOR signal pathway is a novel approach for SCAP-based bone and dentin regeneration.

    DOI: 10.1186/s13287-018-1077-9

  • Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla Reviewed

    Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Shion Hama, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

    Stem Cell Research and Therapy   9 ( 1 )   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-018-1077-9

  • Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth Reviewed

    Haruyoshi Yamaza, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza

    Stem Cell Research and Therapy   9 ( 1 )   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-018-1042-7

  • Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth. Reviewed International journal

    Yamaza H, Sonoda S, Nonaka K, Kukita T, Yamaza T

    Stem cell research & therapy   9 ( 1 )   303 - 303   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth.
    BACKGROUND: Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green pigmentation and dentin hypoplasia in the developing teeth. However, hyperbilirubinemia-induced tooth impairments remain after liver transplantation. No effective dental management to prevent hyperbilirubinemia-induced tooth impairments has been established. METHODS: In this study, we focused on pamidronate, which is used to treat pediatric osteopenia, and investigated its effects on hyperbilirubinemia-induced tooth impairments. We cultured stem cells from human exfoliated deciduous teeth (SHED) under high and low concentrations of unconjugated bilirubin in the presence or absence of pamidronate. We then analyzed the effects of pamidronate on the cell death, associated signal pathways, and dentinogenic function in SHED. RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-κB) signal pathway. The high concentration of unconjugated bilirubin impaired the in vitro and in vivo dentinogenic capacity of SHED, but not the low concentration. We then demonstrated that pamidronate decreased the bilirubin-induced cell death in SHED via the altered AKT, ERK1/2, and NF-κB signal pathways and recovered the bilirubin-impaired dentinogenic function of SHED. CONCLUSIONS: Our findings suggest that pamidronate may prevent tooth abnormalities in pediatric patients with hyperbilirubinemia.

    DOI: 10.1186/s13287-018-1042-7

  • 破骨細胞形成と石灰化を調節する骨芽細胞系特異的細胞表面抗原 骨リモデリングに関与する可能性のある新規プレイヤー(Osteoblast lineage-specific cell-surface antigen regulating osteoclastogenesis and calcification: A possible new player in bone remodeling) Reviewed

    Tamer Badawy, 久本 由香里, 上原 範久, 張 旌旗, 山座 孝義, 久木田 明子, 久木田 敏夫

    2018   175 - 175   2018.9

     More details

    Language:English  

  • Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth. Reviewed

    Yamaza H, Tomoda E, Sonoda S, Nonaka K, Kukita T, Yamaza T

    Oral diseases   24 ( 5 )   809 - 819   2018.7

     More details

    Language:Others  

    Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth.

    DOI: 10.1111/odi.12827

  • Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth Reviewed

    H. Yamaza, E. Tomoda, S. Sonoda, K. Nonaka, T. Kukita, T. Yamaza

    Oral Diseases   24 ( 5 )   809 - 819   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/odi.12827

  • Unique Osteoblast-Specific Cell-Surface Antigen Useful for Odontoblast Ontology and Dentin Regeneration Reviewed

    Tamer Badawy, Yukari Kyumoto Nakamura, Norihisa Uehara, Jing-Qi Zhang, Hidenobu Hiura, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita

    Oral Health & Dental Science   2 ( 2 )   1 - 7   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.33425/2639-9490.1018

  • Unique Osteoblast-specific cell surface antigen useful for odontoblast ontology and dentin regeneration Reviewed International journal

    Tamer Badawy, Yukari Kyumoto-Nakamura, Norihisa Uehara, Jingle Zhang, Hidenobu Hiura, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshi Kukita

    International Journal of Oral Health and Dental Management   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 外科学の新知見(3)再生医療の最前線 ヒト脱落乳歯歯髄幹細胞を用いた腸管神経節細胞僅少症に対する腸管神経再生医療

    吉丸 耕一朗, 山座 孝義, 梶岡 俊一, 高橋 良彰, 柳 佑典, 松浦 俊治, 山座 治義, 小田 義直, 野中 和明, 田口 智章

    日本外科学会定期学術集会抄録集   118回   290 - 290   2018.4

     More details

    Language:Japanese  

  • Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Reviewed International journal

    Sonoda S, Mei YF, Atsuta I, Danjo A, Yamaza H, Hama S, Nishida K, Tang R, Kyumoto-Nakamura Y, Uehara N, Kukita T, Nishimura F, Yamaza T

    Scientific reports   8 ( 1 )   3419 - 3419   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells.
    Nitric oxide (NO) is thought to play a pivotal regulatory role in dental pulp tissues under both physiological and pathological conditions. However, little is known about the NO functions in dental pulp stem cells (DPSCs). We examined the direct actions of a spontaneous NO gas-releasing donor, NOC-18, on the odontogenic capacity of rat DPSCs (rDPSCs). In the presence of NOC-18, rDPSCs were transformed into odontoblast-like cells with long cytoplasmic processes and a polarized nucleus. NOC-18 treatment increased alkaline phosphatase activity and enhanced dentin-like mineralized tissue formation and the expression levels of several odontoblast-specific genes, such as runt related factor 2, dentin matrix protein 1 and dentin sialophosphoprotein, in rDPSCs. In contrast, carboxy-PTIO, a NO scavenger, completely suppressed the odontogenic capacity of rDPSCs. This NO-promoted odontogenic differentiation was activated by tumor necrosis factor-NF-κB axis in rDPSCs. Further in vivo study demonstrated that NOC-18-application in a tooth cavity accelerated tertiary dentin formation, which was associated with early nitrotyrosine expression in the dental pulp tissues beneath the cavity. Taken together, the present findings indicate that exogenous NO directly induces the odontogenic capacity of rDPSCs, suggesting that NO donors might offer a novel host DPSC-targeting alternative to current pulp capping agents in endodontics.

    DOI: 10.1038/s41598-018-21183-6

  • The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model. International journal

    Miya Kanazawa, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, Yuri Matsuura, Kiyoshi Koyano

    International journal of implant dentistry   4 ( 1 )   2 - 2   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40729-017-0112-4

  • IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1 Reviewed

    200 ( 1 )   218 - 228   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    As osteoclasts have the central roles in normal bone remodeling, it is ideal to regulate only the osteoclasts performing pathological bone destruction without affecting normal osteoclasts. Based on a hypothesis that pathological osteoclasts form under the pathological microenvironment of the bone tissues, we here set up optimum culture conditions to examine the entity of pathologically activated osteoclasts (PAOCs). Through searching various inflammatory cytokines and their combinations, we found the highest resorbing activity of osteoclasts when osteoclasts were formed in the presence of M-CSF, receptor activator of NF-κB ligand, and IL-1β. We have postulated that these osteoclasts are PAOCs. Analysis using confocal laser microscopy revealed that PAOCs showed extremely high proton secretion detected by the acid-sensitive fluorescence probe Rh-PM and bone resorption activity compared with normal osteoclasts. PAOCs showed unique morphology bearing high thickness and high motility with motile cellular processes in comparison with normal osteoclasts. We further examined the expression of Kindlin-3 and Talin-1, essential molecules for activating integrin b-chains. Although normal osteoclasts express high levels of Kindlin-3 and Talin-1, expression of these molecules was markedly suppressed in PAOCs, suggesting the abnormality in the adhesion property. When whole membrane surface of mature osteoclasts was biotinylated and analyzed, the IL-1β-induced cell surface protein was detected. PAOCs could form a subpopulation of osteo-clasts possibly different from normal osteoclasts. PAOC-specific molecules could be an ideal target for regulating pathological bone destruction.

    DOI: 10.4049/jimmunol.1602035

  • The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model Reviewed International journal

    Miya Kanazawa, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, Yuri Matsuura, Kiyoshi Koyano

    International Journal of Implant Dentistry   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1. Reviewed International journal

    200 ( 1 )   218 - 228   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1602035

  • In vivo and ex vivo methods of growing a liver bud through tissue connection Reviewed

    Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kohashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi

    Scientific reports   7 ( 1 )   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-14542-2

  • Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments Reviewed

    Norihisa Uehara, Akiko Kukita, Yukari Kyumoto-Nakamura, Takayoshi Yamaza, Hisataka Yasuda, Toshio Kukita

    Laboratory Investigation   97 ( 10 )   1235 - 1244   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2017.55

  • Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments. Reviewed International journal

    Norihisa Uehara, Akiko Kukita, Yukari Kyumoto-Nakamura, Takayoshi Yamaza, Hisataka Yasuda, Toshio Kukita

    Laboratory investigation; a journal of technical methods and pathology   97 ( 10 )   1235 - 1244   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2017.55

  • In vivo and ex vivo methods of growing a liver bud through tissue connection. Reviewed International journal

    Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kohashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi

    Scientific reports   7 ( 1 )   14085 - 14085   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-14542-2

  • Galectin-9による破骨細胞分化抑制因子MafBの発現制御

    久本 由香里, 上原 範久, 久木田 明子, 山座 孝義, 久木田 敏夫

    2016   270 - 270   2016.9

     More details

    Language:Japanese  

  • 破骨細胞形成過程における細胞融合と細胞質分裂の形態学的解析

    張 旌旗, 白鳥 卓麻, 久木田 明子, 山座 孝義, 久木田 敏夫

    2016   489 - 489   2016.9

     More details

    Language:Japanese  

  • 病的に活性化された破骨細胞 形成条件の検討と蛍光プローブを用いた骨吸収イメージング

    白鳥 卓麻, 久木田 明子, 上原 範久, 久本 由香里, 張 旌旗, 山座 孝義, 古谷野 潔, 久木田 敏夫, 浦野 泰照, 神谷 真子, 国府田 絹子

    2016   269 - 269   2016.9

     More details

    Language:Japanese  

  • Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw Reviewed

    Yuri Matsuura, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, Akira Takahashi, Nobuyuki Ueda, Wakana Oshiro, Yoshihiro Tsukiyama, Kiyoshi Koyano

    Stem Cell Research and Therapy   7 ( 1 )   2016.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-016-0367-3

  • Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw. Reviewed International journal

    Matsuura Y, Atsuta I, Ayukawa Y, Yamaza T, Kondo R, Takahashi A, Ueda N, Oshiro W, Tsukiyama Y, Koyano K

    Stem cell research & therapy   7 ( 1 )   119 - 119   2016.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw.
    BACKGROUND: Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues, including bone marrow, adipose, and mucosa. MSCs have the capacity for self-renewal and differentiation. Reports have been published on the systemic administration of MSCs leading to functional improvements by engraftment and differentiation, thus providing a new strategy to regenerate damaged tissues. Recently, it has become clear that MSCs possess immunomodulatory properties and can therefore be used to treat diseases. However, the therapeutic effect mechanisms of MSCs are yet to be determined. Here, we investigated these mechanisms using a medication-related osteonecrosis of the jaw (MRONJ)-like mouse model. METHODS: To generate MRONJ-like characteristics, mice received intravenous zoledronate and dexamethasone two times a week. At 1 week after intravenous injection, maxillary first molars were extracted, and at 1 week after tooth extraction, MSCs were isolated from the bone marrow of the mice femurs and tibias. To compare "diseased MSCs" from MRONJ-like mice (d-MSCs) with "control MSCs" from untreated mice (c-MSCs), the isolated MSCs were analyzed by differentiation and colony-forming unit-fibroblast (CFU-F) assays and systemic transplantation of either d-MSCs or c-MSCs into MRONJ-like mice. Furthermore, we observed the exchange of cell contents among d-MSCs and c-MSCs during coculture with all combinations of each MSC type. RESULTS: d-MSCs were inferior to c-MSCs in differentiation and CFU-F assays. Moreover, the d-MSC-treated group did not show earlier healing in MRONJ-like mice. In cocultures with any combination, MSC pairs formed cell-cell contacts and exchanged cell contents. Interestingly, the exchange among c-MSCs and d-MSCs was more frequently observed than other pairs, and d-MSCs were distinguishable from c-MSCs. CONCLUSIONS: The interaction of c-MSCs and d-MSCs, including exchange of cell contents, contributes to the treatment potential of d-MSCs. This cellular behavior might be one therapeutic mechanism used by MSCs for MRONJ.

    DOI: 10.1186/s13287-016-0367-3

  • Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells Reviewed

    Soichiro Sonoda, Haruyoshi Yamaza, Lan Ma, Yosuke Tanaka, Erika Tomoda, Reona Aijima, Kazuaki Nonaka, Toshio Kukita, Songtao Shi, Fusanori Nishimura, Takayoshi Yamaza

    Scientific reports   6   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep19286

  • Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells International journal

    Soichiro Sonoda, Haruyoshi Yamaza, Lan Ma, Yosuke Tanaka, Erika Tomoda, Reona Aijima, Kazuaki Nonaka, Toshio Kukita, Songtao Shi, Fusanori Nishimura, Takayoshi Yamaza

    Scientific Reports   6   19286 - 19286   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep19286

  • In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice Reviewed

    Takayoshi Yamaza, Fatima Safira Alatas, Ratih Yuniartha, Haruyoshi Yamaza, Junko K. Fujiyoshi, Yusuke Yanagi, Koichiro Yoshimaru, Makoto Hayashida, Toshiharu Matsuura, Reona Aijima, Kenji Ihara, Shouichi Ohga, Songtao Shi, Kazuaki Nonaka, Tomoaki Taguchi

    Stem Cell Research and Therapy   6 ( 1 )   2015.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-015-0154-6

  • In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. Reviewed International journal

    Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T

    Stem cell research & therapy   6 ( 1 )   171 - 171   2015.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.
    INTRODUCTION: Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage of donor organs, alternative therapies have been required. Due to their potential to differentiate into a variety of mature cells, stem cells are considered feasible cell sources for liver regeneration. Stem cells from human exfoliated deciduous teeth (SHED) exhibit hepatogenic capability in vitro. In this study, we investigated their in vivo capabilities of homing and hepatocyte differentiation and therapeutic efficacy for liver disorders in carbon tetrachloride (CCl4)-induced liver fibrosis model mice. METHODS: We transplanted SHED into CCl4-induced liver fibrosis model mice through the spleen, and analyzed the in vivo homing and therapeutic effects by optical, biochemical, histological, immunological and molecular biological assays. We then sorted human leukocyte antigen-ABC (HLA-ABC)-positive cells from primary CCl4-damaged recipient livers, and analyzed their fusogenicity and hepatic characteristics by flow cytometric, genomic DNA, hepatocyte-specific gene assays. Furthermore, we examined the treatment effects of HLA-positive cells to a hepatic dysfunction by a secondary transplantation into CCl4-treated mice. RESULTS: Transplanted SHED homed to recipient livers, and expressed HLA-ABC, human hepatocyte specific antigen hepatocyte paraffin 1 and human albumin. SHED transplantation markedly recovered liver dysfunction and led to anti-fibrotic and anti-inflammatory effects in the recipient livers. SHED-derived HLA-ABC-positive cells that were sorted from the primary recipient liver tissues with CCl4 damage did not fuse with the host mouse liver cells. Sorted HLA-positive cells not only expressed human hepatocyte-specific genes including albumin, cytochrome P450 1A1, fumarylacetoacetase, tyrosine aminotransferase, uridine 5'-diphospho-glucuronosyltransferase, transferrin and transthyretin, but also secreted human albumin, urea and blood urea nitrogen. Furthermore, SHED-derived HLA-ABC-positive cells were secondary transplanted into CCl4-treated mice. The donor cells homed into secondary recipient livers, and expressed hepatocyte paraffin 1 and human albumin, as well as HLA-ABC. The secondary transplantation recovered a liver dysfunction in secondary recipients. CONCLUSIONS: This study indicates that transplanted SHED improve hepatic dysfunction and directly transform into hepatocytes without cell fusion in CCl4-treated mice, suggesting that SHED may provide a feasible cell source for liver regeneration.

    DOI: 10.1186/s13287-015-0154-6

  • Erratum Retraction Notice to: Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-β/SMAD3 Autocrine Loop (Cell Stem Cell (2013) 13 (577-589)) Reviewed

    16 ( 5 )   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2015.04.016

  • Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice. Reviewed International journal

    Ma L, Aijima R, Hoshino Y, Yamaza H, Tomoda E, Tanaka Y, Sonoda S, Song G, Zhao W, Nonaka K, Shi S, Yamaza T

    Stem cell research & therapy   6   104 - 104   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice.
    INTRODUCTION: Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic transplantation of mesenchymal stem cells could ameliorate bone loss and autoimmune disorders in a MRL/lpr mouse systemic lupus erythematosus model, but the detailed therapeutic mechanism of bone regeneration is not fully understood. In this study, we transplanted human bone marrow mesenchymal stem cells (BMMSCs) and stem cells from exfoliated deciduous teeth (SHED) into MRL/lpr mice and explored their therapeutic mechanisms in secondary osteoporotic disorders of the systemic lupus erythematosus model mice. METHODS: The effects of systemic human mesenchymal stem cell transplantation on bone loss of MRL/lpr mice were analyzed in vivo and ex vivo. After systemic human mesenchymal stem cell transplantation, recipient BMMSC functions of MRL/lpr mice were assessed for aspects of stemness, osteogenesis and osteoclastogenesis, and a series of co-culture experiments under osteogenic or osteoclastogenic inductions were performed to examine the efficacy of interleukin (IL)-17-impaired recipient BMMSCs in the bone marrow of MRL/lpr mice. RESULTS: Systemic transplantation of human BMMSCs and SHED recovered the reduction in bone density and structure in MRL/lpr mice. To explore the mechanism, we found that impaired recipient BMMSCs mediated the negative bone metabolic turnover by enhanced osteoclastogenesis and suppressed osteoblastogenesis in secondary osteoporosis of MRL/lpr mice. Moreover, IL-17-dependent hyperimmune conditions in the recipient bone marrow of MRL/lpr mice damaged recipient BMMSCs to suppress osteoblast capacity and accelerate osteoclast induction. To overcome the abnormal bone metabolism, systemic transplantation of human BMMSCs and SHED into MRL/lpr mice improved the functionally impaired recipient BMMSCs through IL-17 suppression in the recipient bone marrow and then maintained a regular positive bone metabolism via the balance of osteoblasts and osteoclasts. CONCLUSIONS: These findings indicate that IL-17 and recipient BMMSCs might be a therapeutic target for secondary osteoporosis in systemic lupus erythematosus.

    DOI: 10.1186/s13287-015-0091-4

  • Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-beta/SMAD3 Autocrine Loop (Retraction of vol 13, pg 577, 2013)

    Haiyan Qin, Cunye Qu, Takayoshi Yamaza, Ruili Yang, Xia Lin, Xue-Yan Duan, Kentaro Akiyama, Yi Liu, Qunzhou Zhang, Chider Chen, Yibu Chen, Hank Heng Qi, Xin-Hua Feng, Anh D. Le, Songtao Shi

    CELL STEM CELL   16 ( 5 )   569 - 569   2015.5

     More details

    Language:English  

    DOI: 10.1016/j.stem.2015.04.016

  • Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice Reviewed

    Lan Ma, Reona Aijima, Yoshihiro Hoshino, Haruyoshi Yamaza, Erika Tomoda, Yosuke Tanaka, Soichiro Sonoda, Guangtai Song, Wei Zhao, Kazuaki Nonaka, Songtao Shi, Takayoshi Yamaza

    Stem Cell Research and Therapy   6 ( 1 )   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13287-015-0091-4

  • Therapeutic potential of mesenchymal stem cell transplantation in a nitrofen-induced congenital diaphragmatic hernia rat model Reviewed

    Ratih Yuniartha, Fatima Safira Alatas, Kouji Nagata, Masaaki Kuda, Yusuke Yanagi, Genshiro Esumi, Takayoshi Yamaza, Yoshiaki Kinoshita, Tomoaki Taguchi

    Pediatric surgery international   30 ( 9 )   907 - 914   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-014-3576-9

  • 間葉系幹細胞の直接的/間接的な組織再生への関与を考える 間葉系幹細胞誘導性インプラント周囲粘膜の構築

    熱田 生, 鮎川 保則, 山座 孝義, 近藤 綾介, 松浦 由梨, 古谷野 潔

    2014   79 - 79   2014.9

     More details

    Language:Japanese  

  • Therapeutic potential of mesenchymal stem cell transplantation in a nitrofen-induced congenital diaphragmatic hernia rat model. International journal

    Ratih Yuniartha, Fatima Safira Alatas, Kouji Nagata, Masaaki Kuda, Yusuke Yanagi, Genshiro Esumi, Takayoshi Yamaza, Yoshiaki Kinoshita, Tomoaki Taguchi

    Pediatric surgery international   30 ( 9 )   907 - 14   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-014-3576-9

  • 四塩化炭素誘導肝硬変モデルマウスに対するヒト脱落乳歯幹細胞移植療法の有効性に関する研究

    柳 佑典, Alatas Fatima Safira, 吉丸 耕一朗, 林田 真, 大賀 正一, 山座 治義, 山座 孝義, 田口 智章

    日本小児外科学会雑誌   50 ( 3 )   694 - 694   2014.4

     More details

    Language:Japanese  

  • Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis Reviewed

    Toshio Takano, Yin Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

    Laboratory Investigation   94 ( 3 )   286 - 296   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2013.152

  • Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. Reviewed International journal

    Chider Chen, Kentaro Akiyama, Takayoshi Yamaza, Yong-Ouk You, Xingtian Xu, Bei Li, Yimin Zhao, Songtao Shi

    EMBO molecular medicine   6 ( 3 )   322 - 34   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/emmm.201303000

  • Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis Reviewed International journal

    Toshio Takano, Yin-Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita

    LABORATORY INVESTIGATION   94 ( 3 )   286 - 296   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2013.152

  • Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa Reviewed

    Ryosuke Kondo, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Yuri Matsuura, Akihiro Furuhashi, Yoshihiro Tsukiyama, Kiyoshi Koyano

    PloS one   9 ( 3 )   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0090681

  • Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression Reviewed

    Chider Chen, Kentaro Akiyama, Takayoshi Yamaza, Yong Ouk You, Xingtian Xu, Bei Li, Yimin Zhao, Songtao Shi

    EMBO Molecular Medicine   6 ( 3 )   322 - 334   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/emmm.201303000

  • The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium. Reviewed International journal

    Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Koyano K

    Archives of oral biology   58 ( 11 )   1696 - 1708   2013.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium.
    BACKGROUND: Oral epithelial cells (OECs) adhesion to titanium may improve the success rate of implant restoration. PURPOSE: We investigated the mechanism by which OECs adhere to titanium dental implants. MATERIALS AND METHODS: (1) After culturing rat OECs on titanium plates (Ti) or culture dishes in the presence or absence of a phosphoinositide 3-kinase (PI3K) activator or inhibitors and/or growth factors, and OEC morphology under these conditions were analyzed. (2) Right maxillary first molars were extracted and replaced with experimental implants. The rats were treated with or without growth factors. RESULTS: (1) Cell adherence was lower of OECs on Ti than in those on culture dishes, as were the levels of integrin β4 and the continuity of F-actin structures. After PI3K inhibition, markedly reducing adherence to both substrates. In contrast, PI3K activation with activator or insulin-like growth factor restored the OEC adherence and the expression of adhesion molecules on Ti to the levels seen in OECs cultured on dishes. Cell migration was inhibited by PI3K activation. (2) High expression of integrin β4 was observed in the peri-implant epithelia of PI3K-activated rats. CONCLUSION: These findings suggest that PI3K plays an important role in the adhesion of OECs to Ti.

    DOI: 10.1016/j.archoralbio.2013.07.013

  • Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop. International journal

    13 ( 5 )   577 - 89   2013.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Abnormal stem cell function makes a known contribution to many malignant tumors, but the role of stem cells in benign tumors is not well understood. Here, we show that ossifying fibroma (OF) contains a stem cell population that resembles mesenchymal stem cells (OFMSCs) and is capable of generating OF-like tumor xenografts. Mechanistically, OFMSCs show enhanced TGF-β signaling that induces aberrant proliferation and deficient osteogenesis via Notch and BMP signaling pathways, respectively. The elevated TGF-β activity is tightly regulated by JHDM1D-mediated epigenetic regulation of thrombospondin-1 (TSP1), forming a JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop. Inhibition of TGF-β signaling in OFMSCs can rescue their abnormal osteogenic differentiation and elevated proliferation rate. Furthermore, chronic activation of TGF-β can convert normal MSCs into OF-like MSCs via establishment of this JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop. These results reveal that epigenetic regulation of TGF-β signaling in MSCs governs the benign tumor phenotype in OF and highlight TGF-β signaling as a candidate therapeutic target.

    DOI: 10.1016/j.stem.2013.08.010

  • Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop. Reviewed

    13 ( 5 )   577 - 589   2013.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Abnormal stem cell function makes a known contribution to many malignant tumors, but the role of stem cells in benign tumors is not well understood. Here, we show that ossifying fibroma (OF) contains a stem cell population that resembles mesenchymal stem cells (OFMSCs) and is capable of generating OF-like tumor xenografts. Mechanistically, OFMSCs show enhanced TGF-β signaling that induces aberrant proliferation and deficient osteogenesis via Notch and BMP signaling pathways, respectively. The elevated TGF-β activity is tightly regulated by JHDM1D-mediated epigenetic regulation of thrombospondin-1 (TSP1), forming a JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop. Inhibition of TGF-β signaling in OFMSCs can rescue their abnormal osteogenic differentiation and elevated proliferation rate. Furthermore, chronic activation of TGF-β can convert normal MSCs into OF-like MSCs via establishment of this JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop. These results reveal that epigenetic regulation of TGF-β signaling in MSCs governs the benign tumor phenotype in OF and highlight TGF-β signaling as a candidate therapeutic target.

  • Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants Reviewed International journal

    ATSUTA IKIRU, AYUKAWA Yasunori, Furuhashi Akihiko, Yamaza Takayoshi, TSUKIYAMA Yoshihiro, KOYANO Kiyoshi

    J Biomed Mater Res A   101 ( 10 )   2896 - 2904   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants
    Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. Here, we investigated whether insulin-like growth factor-1 (IGF-1) improved the sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with experimental implants. After 4 weeks of IGF-1 treatment, the implant-PIE interface exhibited a band of immunoreactive laminin-332 (Ln-5), similar to the tooth-junctional epithelium interface, that was partially absent in the untreated group. Immunoelectron microscopy showed a characteristic Ln-5-positive band including hemidesmosomes at both the apical and upper portions of the implant-PIE interface in the IGF-1-treated group. We also investigated the effects of IGF-1/PI3K inhibitors on the dynamics of rat oral epithelial cells (OECs) grown on Ti plates. In OECs cultured with IGF-1, adhesion protein expression increased, cell adherence to Ti plates was higher, and proliferation was faster, whereas migration and apoptosis were induced in the absence of IGF-1 or in the presence of both IGF-1 and a PI3K inhibitor. These data suggest that PI3K mediates the promotive effects of IGF-1, and that IGF-1 is effective at enhancing epithelial integration around Ti implants.

    DOI: 10.1002/jbm.a.34608

  • The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium Reviewed

    Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Kiyoshi Koyano

    Archives of Oral Biology   58 ( 11 )   1696 - 1708   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.archoralbio.2013.07.013

  • Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants Reviewed

    Ikiru Atsuta, Yasunori Ayukawa, Akihiro Furuhashi, Takayoshi Yamaza, Yoshihiro Tsukiyama, Kiyoshi Koyano

    Journal of Biomedical Materials Research - Part A   101 ( 10 )   2896 - 2904   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.34608

  • 膜ナノチューブを介する破骨前駆細胞間融合の走査電顕的解析

    張 旌旗, 高橋 良, 久木田 明子, 成松 加奈子, 上原 範久, 山座 孝義, 城戸 瑞穂, 久木田 敏夫

    2013   207 - 207   2013.9

     More details

    Language:Japanese  

  • Effect of allergen sensitization on external root resorption Reviewed

    N. Murata, H. Ioi, M. Ouchi, T. Takao, H. Oida, R. Aijima, T. Yamaza, M. A. Kido

    Journal of Dental Research   92 ( 7 )   641 - 647   2013.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034513488787

  • Immune therapeutic potential of stem cells from human supernumerary teeth. Reviewed

    Makino Y, Yamaza H, Akiyama K, Ma L, Hoshino Y, Nonaka K, Terada Y, Kukita T, Shi S, Yamaza T

    Journal of dental research   92 ( 7 )   609 - 615   2013.7

     More details

    Language:Others  

    Immune therapeutic potential of stem cells from human supernumerary teeth.

    DOI: 10.1177/0022034513490732

  • Immune therapeutic potential of stem cells from human supernumerary teeth Reviewed

    Y. Makino, H. Yamaza, K. Akiyama, L. Ma, Y. Hoshino, K. Nonaka, Y. Terada, T. Kukita, S. Shi, T. Yamaza

    Journal of Dental Research   92 ( 7 )   609 - 615   2013.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034513490732

  • Tunneling nanotube formation is essential for the regulation of osteoclastogenesis Reviewed

    akira takahashi, Akiko Kukita, Yin Ji Li, Jing Qi Zhang, Hisayuki Nomiyama, Takayoshi Yamaza, Yasunori Ayukawa, Kiyoshi Koyano, Toshio Kukita

    Journal of Cellular Biochemistry   114 ( 6 )   1238 - 1247   2013.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcb.24433

  • Tunneling nanotube formation is essential for the regulation of osteoclastogenesis. Reviewed International journal

    Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K, Kukita T

    Journal of cellular biochemistry   114 ( 6 )   1238 - 1247   2013.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
    Osteoclasts are the multinucleated giant cells formed by cell fusion of mononuclear osteoclast precursors. Despite the finding of several membrane proteins involving DC-STAMP as regulatory proteins required for fusion among osteoclast precursors, cellular and molecular events concerning this process are still ambiguous. Here we identified Tunneling Nanotubes (TNTs), long intercellular bridges with small diameters, as the essential cellular structure for intercellular communication among osteoclast precursors in prior to cell fusion. Formation of TNTs was highly associated with osteoclastogenesis and it was accompanied with the significant induction of the M-Sec gene, an essential gene for TNT formation. M-Sec gene expression was significantly upregulated by RANKL-treatment in osteoclast precursor cell line. Blockage of TNT formation by Latrunclin B or by M-Sec siRNA significantly suppressed osteoclastogenesis. We have detected the rapid intercellular transport of not only the membrane phospholipids labeled with DiI but also the DC-STAMP-GFP fusion protein through TNTs formed among osteoclast precursors during osteoclastogenesis. Transportation of such regulatory molecules through TNTs would be essential for the process of the specific cell fusion among osteoclast precursors.

    DOI: 10.1002/jcb.24433

  • Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation

    Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ryosuke Kondo, Kiyoshi Koyano

    Key Engineering Materials   529-530   407 - 412   2013.1

     More details

    Language:English  

    Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation
    Integrin, a component of the hemidesmosome, plays a role for epithelial cell migration and adhesion. This study investigated the process of peri-implant epithelium (PIE) formation after implantation, and compared it to the process of oral mucosa healing after tooth extraction. At the healing site of extraction socket without implant, the original junctional epithelium (JE) had disappeared at week 2, and the oral epithelium (OE) with integrin-α3 positive basal cells extending from the sides of the wound, then joined in the middle of the extraction socket. On the other hand in implant group, newly formed epithelium with integrin-α3 positive cells from the OE extended apically 1 week after implantation. After 3 weeks, basal cells of the new epithelium consisted of those with integrin-α3 positive but β4 negative. Finally, after 4 weeks, integrin-β4 was expressed at the implant-PIE interface. These findings suggest that integrin α3β1 plays a role in cell migration during PIE formation from OE. Furthermore, after the completion of PIE constitution, integrin α6β4 contributes to the attachment to titanium. © (2013) Trans Tech Publications, Switzerland.

    DOI: 10.4028/www.scientific.net/KEM.529-530.407

  • Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation

    Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ryosuke Kondo, Kiyoshi Koyano

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 Bioceramics 24   407 - 412   2013.1

     More details

    Language:English   Publishing type:Research paper (other academic)  

    DOI: 10.4028/www.scientific.net/KEM.529-530.407

  • Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine Reviewed International journal

    Lan Ma, Yusuke Makino, Haruyoshi Yamaza, Kentaro Akiyama, Yoshihiro Hoshino, Guangtai Song, Toshio Kukita, Kazuaki Nonaka, Songtao Shi, Takayoshi Yamaza

    PLOS ONE   7 ( 12 )   e51777   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0051777

  • Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine Reviewed

    Lan Ma, Yusuke Makino, Haruyoshi Yamaza, Kentaro Akiyama, Yoshihiro Hoshino, Guangtai Song, Toshio Kukita, Kazuaki Nonaka, Songtao Shi, Takayoshi Yamaza

    PloS one   7 ( 12 )   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0051777

  • Characterization of bone marrow derived mesenchymal stem cells in suspension Reviewed

    Kentaro Akiyama, Yong Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao Dong Chen, Stan Gronthos, Songtao Shi

    Stem Cell Research and Therapy   3 ( 5 )   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/scrt131

  • Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus Reviewed

    Dandan Wang, Kentaro Akiyama, Huayong Zhang, Takayoshi Yamaza, Xia Li, Xuebing Feng, Hong Wang, Bingzhu Hua, Bujun Liu, Huji Xu, Wanjun Chen, Songtao Shi, Lingyun Sun

    Clinical and Developmental Immunology   2012   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2012/273291

  • Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis Reviewed International journal

    Kentaro Akiyama, Chider Chen, Dandan Wang, Xingtian Xu, Cunye Qu, Takayoshi Yamaza, Tao Cai, Wanjun Chen, Lingyun Sun, Songtao Shi

    Cell Stem Cell   10 ( 5 )   544 - 555   2012.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2012.03.007

  • Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis Reviewed

    Kentaro Akiyama, Chider Chen, Dandan Wang, Xingtian Xu, Cunye Qu, Takayoshi Yamaza, Tao Cai, Wanjun Chen, Lingyun Sun, Songtao Shi

    Cell stem cell   10 ( 5 )   544 - 555   2012.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2012.03.007

  • 間葉系幹細胞による炎症性骨破壊制御

    高野登志雄, LI Y, 久木田明子, 山座孝義, 高橋良, 鮎川保則, 古谷野潔, 久木田敏夫

    53 ( Supplement )   131   2011.9

     More details

    Language:Japanese  

  • Mouse mandible contains distinctive mesenchymal stem cells Reviewed

    T. Yamaza, G. Ren, K. Akiyama, C. Chen, Y. Shi, S. Shi

    Journal of Dental Research   90 ( 3 )   317 - 324   2011.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034510387796

  • Mouse Mandible Contains Distinctive Mesenchymal Stem Cells Reviewed

    T. Yamaza, G. Ren, K. Akiyama, C. Chen, Y. Shi, S. Shi

    JOURNAL OF DENTAL RESEARCH   90 ( 3 )   317 - 324   2011.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034510387796

  • Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Reviewed

    Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi

    Stem Cell Research and Therapy   1 ( 1 )   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/scrt5

  • Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors Reviewed International journal

    Sara Parsa, Koh-Ichi Kuremoto, Kerstin Seidel, Reza Tabatabai, BreAnne MacKenzie, Takayoshi Yamaza, Kentaro Akiyama, Jonathan Branch, Chester J. Koh, Denise Al Alam, Ophir D. Klein, Saverio Bellusci

    Development   137 ( 22 )   3743 - 3752   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.051672

  • Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors Reviewed

    Sara Parsa, Koh Ichi Kuremoto, Kerstin Seidel, Reza Tabatabai, Bre Anne MacKenzie, Takayoshi Yamaza, Kentaro Akiyama, Jonathan Branch, Chester J. Koh, Denise Al Alam, Ophir D. Klein, Saverio Bellusci

    Development   137 ( 22 )   3743 - 3752   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.051672

  • Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice Reviewed

    Takashi Kikuiri, Insoo Kim, Takyoshi Yamaza, Kentaro Akiyama, Qunzhou Zhang, Yunsheng Li, Chider Chen, Wan Jun Chen, Songlin Wang, Anh D. Le, Songtao Shi

    Journal of Bone and Mineral Research   25 ( 7 )   1668 - 1679   2010.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbmr.37

  • Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential Reviewed International journal

    Dominick J Alongi, Takayoshi Yamaza, Yingjie Song, Ashraf F Fouad, Elaine E Romberg, Songtao Shi, Rocky S Tuan, George T-J Huang

    Regenerative Medicine   5 ( 4 )   617 - 631   2010.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2217/rme.10.30

  • Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential Reviewed

    Dominick J. Alongi, Takayoshi Yamaza, Yingjie Song, Ashraf F. Fouad, Elaine E. Romberg, Songtao Shi, Rocky S. Tuan, George T.J. Huang

    Regenerative Medicine   5 ( 4 )   617 - 631   2010.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2217/rme.10.30

  • TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis Reviewed International journal

    Ryoichi Hosokawa, Kyoko Oka, Takayoshi Yamaza, Junichi Iwata, Mark Urata, Xun Xu, Pablo Bringas, Kazuaki Nonaka, Yang Chai

    DEVELOPMENTAL BIOLOGY   341 ( 1 )   186 - 195   2010.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2010.02.030

  • TGF-β mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis Reviewed

    341 ( 1 )   186 - 195   2010.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Skeletal muscles are formed from two cell lineages, myogenic and fibroblastic. Mesoderm-derived myogenic progenitors form muscle cells whereas fibroblastic cells give rise to the supportive connective tissue of skeletal muscles, such as the tendons and perimysium. It remains unknown how myogenic and fibroblastic cell-cell interactions affect cell fate determination and the organization of skeletal muscle. In the present study, we investigated the functional significance of cell-cell interactions in regulating skeletal muscle development. Our study shows that cranial neural crest (CNC) cells give rise to the fibroblastic cells of the tongue skeletal muscle in mice. Loss of Tgfbr2 in CNC cells (Wnt1-Cre;Tgfbr2flox/flox) results in microglossia with reduced Scleraxis and Fgf10 expression as well as decreased myogenic cell proliferation, reduced cell number and disorganized tongue muscles. Furthermore, TGF-β2 beads induced the expression of Scleraxis in tongue explant cultures. The addition of FGF10 rescued the muscle cell number in Wnt1-Cre;Tgfbr2flox/flox mice. Thus, TGF-β induced FGF10 signaling has a critical function in regulating tissue-tissue interaction during tongue skeletal muscle development.

    DOI: 10.1016/j.ydbio.2010.02.030

  • Stem/Progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model Reviewed

    George T.J. Huang, Takayoshi Yamaza, Lonnie D. Shea, Farida Djouad, Nastaran Z. Kuhn, Rocky S. Tuan, Songtao Shi

    Tissue Engineering - Part A   16 ( 2 )   605 - 615   2010.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/ten.tea.2009.0518

  • Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. International journal

    George T-J Huang, Takayoshi Yamaza, Lonnie D Shea, Farida Djouad, Nastaran Z Kuhn, Rocky S Tuan, Songtao Shi

    Tissue engineering. Part A   16 ( 2 )   605 - 15   2010.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/ten.TEA.2009.0518

  • Utility of PDL progenitors for in vivo tissue regeneration A report of 3 cases Reviewed

    F. Feng, K. Akiyama, Y. Liu, T. Yamaza, T. M. Wang, J. H. Chen, B. B. Wang, G. T.J. Huang, S. Wang, S. Shi

    Oral Diseases   16 ( 1 )   20 - 28   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2009.01593.x

  • Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis Reviewed

    Qunzhou Zhang, Takayoshi Yamaza, A. Paul Kelly, Shihong Shi, Songlin Wang, Jimmy Brown, Lina Wang, Samuel W. French, Songtao Shi, Anh D. Le

    PloS one   4 ( 11 )   2009.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0007798

  • Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis. International journal

    Qunzhou Zhang, Takayoshi Yamaza, A Paul Kelly, Shihong Shi, Songlin Wang, Jimmy Brown, Lina Wang, Samuel W French, Songtao Shi, Anh D Le

    PloS one   4 ( 11 )   e7798   2009.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0007798

  • TRPV2 expression in rat oral mucosa Reviewed

    Daiji Shimohira, Mizuho A. Kido, Atsushi Danjo, Tomoka Takao, Bing Wang, Jing Qi Zhang, Takayoshi Yamaza, Sadahiko Masuko, Masaaki Goto, Teruo Tanaka

    Histochemistry and Cell Biology   132 ( 4 )   423 - 433   2009.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00418-009-0616-y

  • TRPV2 expression in rat oral mucosa. Reviewed International journal

    Shimohira D, Kido MA, Danjo A, Takao T, Wang B, Zhang JQ, Yamaza T, Masuko S, Goto M, Tanaka T

    Histochemistry and cell biology   132 ( 4 )   423 - 433   2009.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    TRPV2 expression in rat oral mucosa.
    The oral mucosa is a highly specialised, stratified epithelium that confers protection from infection and physical, chemical and thermal stimuli. The non-keratinised junctional epithelium surrounds each tooth like a collar and is easily attacked by foreign substances from the oral sulcus. We found that TRPV2, a temperature-gated channel, is highly expressed in junctional epithelial cells, but not in oral sulcular epithelial cells or oral epithelial cells. Dual or triple immunolabelling with immunocompetent cell markers also revealed TRPV2 expression in Langerhans cells and in dendritic cells and macrophages. Electron microscopy disclosed TRPV2 immunoreactivity in the unmyelinated and thinly myelinated axons within the connective tissue underlying the epithelium. TRPV2 labelling was also observed in venule endothelial cells. The electron-dense immunoreaction in junctional epithelial cells, macrophages and neural axons occurred on the plasma membrane, on invaginations of the plasma membrane and in vesicular structures. Because TRPV2 has been shown to respond to temperature, hypotonicity and mechanical stimuli, gingival cells expressing TRPV2 may act as sensor cells, detecting changes in the physical and chemical environment, and may play a role in subsequent defence mechanisms.

    DOI: 10.1007/s00418-009-0616-y

  • BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. International journal

    Zhipeng Fan, Takayoshi Yamaza, Janice S Lee, Jinhua Yu, Songlin Wang, Guoping Fan, Songtao Shi, Cun-Yu Wang

    Nature cell biology   11 ( 8 )   1002 - 9   2009.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncb1913

  • BCOR regulates mesenchymal stem cell function by epigenetic mechanisms Reviewed

    Zhipeng Fan, Takayoshi Yamaza, Janice S. Lee, Jinhua Yu, Songlin Wang, Guoping Fan, Songtao Shi, Cun Yu Wang

    Nature Cell Biology   11 ( 8 )   1002 - 1009   2009.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncb1913

  • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. International journal

    Lingyun Sun, Kentaro Akiyama, Huayong Zhang, Takayoshi Yamaza, Yayi Hou, Shengnan Zhao, Ting Xu, Anh Le, Songtao Shi

    Stem cells (Dayton, Ohio)   27 ( 6 )   1421 - 32   2009.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.68

  • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans Reviewed

    Lingyun Sun, Kentaro Akiyama, Huayong Zhang, Takayoshi Yamaza, Yayi Hou, Shengnan Zhao, Ting Xu, Anh Le, Songtao Shi

    STEM CELLS   27 ( 6 )   1421 - 1432   2009.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.68

  • Erratum SHED repair critical-size calvarial defects in mice. (Oral Dis (2008) 14:(428-434)) Reviewed

    B. M. Seo, W. Sonoyama, T. Yamaza, C. Coppe, T. Kikuiri, K. Akiyama, J. S. Lee, S. Shi

    Oral Diseases   15 ( 4 )   2009.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2009.01564.x

  • Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development Reviewed

    Il Hyuk Chung, Takayoshi Yamaza, Hu Zhao, Pill Hoon Choung, Songtao Shi, Yang Chai

    STEM CELLS   27 ( 4 )   866 - 877   2009.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.2

  • Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. International journal

    Il-Hyuk Chung, Takayoshi Yamaza, Hu Zhao, Pill-Hoon Choung, Songtao Shi, Yang Chai

    Stem cells (Dayton, Ohio)   27 ( 4 )   866 - 77   2009.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.2

  • Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice Reviewed

    Takayoshi Yamaza, Yasuo Miura, Kentaro Akiyama, Yanming Bi, Wataru Sonoyama, Stan Gronthos, Wanjun Chen, Anh Le, Songtao Shi

    Blood   113 ( 11 )   2595 - 2604   2009.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2008-10-182246

  • Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice Reviewed International journal

    Takayoshi Yamaza, Yasuo Miura, Kentaro Akiyama, Yanming Bi, Wataru Sonoyama, Stan Gronthos, Wanjun Chen, Anh Le, Songtao Shi

    Blood   113 ( 11 )   2595 - 2604   2009.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2008-10-182246

  • Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats Reviewed

    Takayoshi Yamaza, Mizuho A. Kido, Bing Wang, Atsushi Danjo, Daiji Shimohira, Naohisa Murata, Masao Yoshinari, Teruo Tanaka

    Cell and tissue research   335 ( 2 )   407 - 415   2009.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-008-0720-7

  • Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats. Reviewed International journal

    Yamaza T, Kido MA, Wang B, Danjo A, Shimohira D, Murata N, Yoshinari M, Tanaka T

    Cell and tissue research   335 ( 2 )   407 - 415   2009.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats.
    We examined the distribution of substance P and neurokinin-1 (NK1) receptors and substance-P-containing nerve fibers in the peri-implant mucosa around titanium dental implants in rats. Immunohistochemistry and immunocytochemistry revealed that substance-P-immunoreactive nerve fibers abundantly innervated the peri-implant epithelium (PIE) compared with other epithelia of the peri-implant mucosa. NK1 receptor mRNA and protein expression in the peri-implant mucosa were confirmed by reverse transcription with the polymerase chain reaction and immunoblotting. Immunoelectron microscopy revealed that NK1 receptor immunoreactivity was preferentially localized in peri-implant epithelial cells. NK1-receptor-positive products were found on the plasma membrane and in vesicles and granules in PIE cells. Neutrophils and intraepithelial nerve axons in the PIE were positive for the NK1 receptor. NK1 receptor immunoreactivity was also detected in endothelial cells, fibroblasts, and nerve fibers in the connective tissue beneath the PIE. These findings suggest that peri-implant tissue receives sensory information through regenerated nerves expressing substance P and the NK1 receptor. In the peri-implant mucosa, the substance P/NK1 receptor system may play a role in pain transmission, the endocytosis of neutrophils, the extravasation of crevicular fluid, and the migration of macrophages and neutrophils in response to neurogenic inflammation, as in healthy gingiva.

    DOI: 10.1007/s00441-008-0720-7

  • Is aspirin treatment an appropriate intervention for osteoporosis? Reviewed

    Takayoshi Yamaza, Kentaro Akiyama, Songtao Shi

    Future Rheumatology   3 ( 6 )   499 - 502   2008.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2217/17460816.3.6.499

  • Is aspirin treatment an appropriate intervention to osteoporosis? International journal

    Songtao Shi, Takayoshi Yamaza, Kentaro Akiyama

    Future rheumatology   3 ( 6 )   499 - 502   2008.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents Reviewed

    Takayoshi Yamaza, Yasuo Miura, Yanming Bi, Yongzhong Liu, Kentaro Akiyama, Wataru Sonoyama, Voymesh Patel, Silvio Gutkind, Marian Young, Stan Gronthos, Anh Le, Cun Yu Wang, Wan Jun Chen, Songtao Shi

    PloS one   3 ( 7 )   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0002615

  • SHED repair critical-size calvarial defects in mice Reviewed

    B. M. Seo, W. Sonoyama, T. Yamaza, C. Coppe, T. Kikuiri, K. Akiyama, J. S. Lee, S. Shi

    ORAL DISEASES   14 ( 5 )   428 - 434   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2007.01396.x

  • Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents Reviewed International journal

    Takayoshi Yamaza, Yasuo Miura, Yanming Bi, Yongzhong Liu, Kentaro Akiyama, Wataru Sonoyama, Voymesh Patel, Silvio Gutkind, Marian Young, Stan Gronthos, Anh Le, Cun-Yu Wang, Wan Jun Chen, Songtao Shi

    PLoS ONE   3 ( 7 )   e2615   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0002615

  • SHED repair critical-size calvarial defects in mice Reviewed

    B. M. Seo, W. Sonoyama, T. Yamaza, C. Coppe, T. Kikuiri, K. Akiyama, J. S. Lee, S. Shi

    Oral Diseases   14 ( 5 )   428 - 434   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2007.01396.x

  • Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth A Pilot Study Reviewed

    Wataru Sonoyama, Yi Liu, Takayoshi Yamaza, Rocky S. Tuan, Songlin Wang, Songtao Shi, George T.J. Huang

    Journal of Endodontics   34 ( 2 )   166 - 171   2008.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joen.2007.11.021

  • Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot Study Reviewed International journal

    Wataru Sonoyama, Yi Liu, Takayoshi Yamaza, Rocky S. Tuan, Songlin Wang, Songtao Shi, George T.-J. Huang

    Journal of Endodontics   34 ( 2 )   166 - 171   2008.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joen.2007.11.021

  • P41.シスタチンCは骨髄由来間様系幹細胞の骨への分化を促進する(一般演題抄録,第5回日本再生歯科学会)

    檀上 敦, 山座 孝義, 城戸 瑞穂, 下平 大治, 田中 輝男

    日本再生歯科医学会誌   5 ( 1 )   73 - 73   2007.12

     More details

    Language:Japanese  

  • Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation Reviewed

    Atsushi Danjo, Takayoshi Yamaza, Mizuho A. Kido, Daiji Shimohira, Takayuki Tsukuba, Tadayoshi Kagiya, Yoshio Yamashita, Katsushi Nishijima, Sadahiko Masuko, Masaaki Goto, Teruo Tanaka

    Biochemical and Biophysical Research Communications   360 ( 1 )   199 - 204   2007.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2007.06.028

  • Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation. Reviewed International journal

    Danjo A, Yamaza T, Kido MA, Shimohira D, Tsukuba T, Kagiya T, Yamashita Y, Nishijima K, Masuko S, Goto M, Tanaka T

    Biochemical and biophysical research communications   360 ( 1 )   199 - 204   2007.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation.
    Cystatin C (CysC) is a natural cysteine proteinase inhibitor that suppresses the differentiation and bone-resorptive function of osteoclasts. By contrast, the effect of CysC on the differentiation and bone-formative function of osteoblasts has not been elucidated thoroughly. We examined the effects of CysC on mouse osteoblastic cells using in vitro cultures from bone marrow and calvaria and ex vivo calvarial cultures. CysC-stimulated cells showed increased alkaline phosphatase (ALP) activity, mineralization of the new bone matrix, and calvarial bone formation. The cells treated with CysC immunodepleted by anti-CysC antibody (iCysC) and a chemical papain-like cysteine proteinase inhibitor, E-64, did not induce mineralization. Elevated mRNA levels of bone morphogenetic protein (BMP)-2, the differentiation marker osteocalcin, and a master osteogenic transcription factor, Runx2, were observed in CysC-treated cells. These results suggest that CysC affects the BMP signaling cascades in osteoblastic cells and then promotes osteoblast differentiation, mineralization, and bone formation.

    DOI: 10.1016/j.bbrc.2007.06.028

  • Human Hertwig's epithelial root sheath cells play crucial roles in cementum formation Reviewed

    W. Sonoyama, B. M. Seo, T. Yamaza, S. Shi

    Journal of Dental Research   86 ( 7 )   594 - 599   2007.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/154405910708600703

  • Human Hertwig's epithelial root sheath cells play crucial roles in cementum formation Reviewed

    W. Sonoyama, B. M. Seo, T. Yamaza, S. Shi

    Journal of Dental Research   86 ( 7 )   594 - 599   2007.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/154405910708600703

  • Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery. Reviewed International journal

    Dianji Fang, Byoung-Moo Seo, Yi Liu, Wataru Sonoyama, Takayoshi Yamaza, Chunmei Zhang, Songlin Wang, Songtao Shi

    Stem cells (Dayton, Ohio)   25 ( 4 )   1021 - 8   2007.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars. Reviewed International journal

    Mei YF, Yamaza T, Atsuta I, Danjo A, Yamashita Y, Kido MA, Goto M, Akamine A, Tanaka T

    Cell and tissue research   328 ( 1 )   117 - 127   2007.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars.
    Nitric oxide (NO) stimulates osteoblast differentiation, but whether NO contributes to odontoblast differentiation during dentin repair is unknown. By using reverse transcription/polymerase chain reaction and immunostaining, we investigated the gene expression and/or immunolocalization of endothelial NO synthase (eNOS), inducible NOS (iNOS), and nitrotyrosine (a biomarker for NO-derived peroxinitrite), and alkaline phosphatase (ALP) and osteocalcin (early and terminal differentiation markers of odontoblasts, respectively) in dental pulp tissue after rat tooth preparation. At the early stage (1-3 days) post-preparation, markedly increased expression of iNOS and nitrotyrosine was found in odontoblasts and pulp cells beneath the cavity, whereas eNOS expression was significantly decreased. ALP mRNA expression was significantly increased after 1 day but decreased after 3 days, whereas ALP activity was weak in the dentin-pulp interface under the cavity after 1 day but strong after 3 days. Osteocalcin mRNA expression was significantly increased at this stage. At 7 days post-preparation, tertiary dentin was formed under the cavity. All the molecules studied were expressed at control levels in odontoblasts/pulp cells beneath the cavity. These findings show that abundant NO is released from odontoblasts and pulp cells at an early stage after tooth preparation and indicate that, after tooth preparation, the up-regulation of iNOS and nitrotyrosine in odontoblasts is synchronized with increased cellular expression of ALP and osteocalcin. Therefore, the NO synthesized by iNOS after tooth preparation probably participates in regulating odontoblast differentiation during tertiary dentinogenesis.

    DOI: 10.1007/s00441-005-0003-5

  • Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery Reviewed

    Dianji Fang, Byoung Moo Seo, Yi Liu, Wataru Sonoyama, Takayoshi Yamaza, Chunmei Zhang, Songlin Wang, Songtao Shi

    STEM CELLS   25 ( 4 )   1021 - 1028   2007.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1634/stemcells.2006-0576

  • Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars Reviewed

    Yu Feng Mei, Takayoshi Yamaza, Ikiru Atsuta, Atsushi Danjo, Yoshio Yamashita, Mizuho A. Kido, Masaaki Goto, Akifumi Akamine, Teruo Tanaka

    Cell and tissue research   328 ( 1 )   117 - 127   2007.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-005-0003-5

  • Multipotent Stem Cells in Dental Pulp

    Wataru Sonoyama, Takayoshi Yamaza, Stan Gronthos, Songtao Shi

    Culture of Human Stem Cells   187 - 206   2007.1

     More details

    Language:English  

    DOI: 10.1002/9780470167526.ch8

  • Multipotent Stem Cells in Dental Pulp Reviewed

    Wataru Sonoyama, Takayoshi Yamaza, Stan Gronthos, Songtao Shi

    Culture of Human Stem Cells   187 - 206   2007.1

     More details

    Language:English  

    DOI: 10.1002/9780470167526.ch8

  • Mesenchymal stem cell-mediated functional tooth regeneration in Swine Reviewed

    Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun Yu Wang, Songtao Shi, Songlin Wang

    PloS one   1 ( 1 )   2006.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0000079

  • Mesenchymal stem cell-mediated functional tooth regeneration in Swine Reviewed International journal

    Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songtao Shi, Songlin Wang

    PLoS ONE   1 ( 1 )   e79   2006.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0000079

  • Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region Reviewed

    M. Miura, Y. Miura, W. Sonoyama, Takayoshi Yamaza, S. Gronthos, S. Shi

    Oral Diseases   12 ( 6 )   514 - 522   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2006.01300.x

  • Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region Reviewed

    M. Miura, Y. Miura, W. Sonoyama, T. Yamaza, S. Gronthos, S. Shi

    ORAL DISEASES   12 ( 6 )   514 - 522   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-0825.2006.01300.x

  • Capsaicin receptor expression in the rat temporomandibular joint Reviewed

    Hideki Ioi, Mizuho A. Kido, Jing Qi Zhang, Takayoshi Yamaza, Shunsuke Nakata, Akihiko Nakasima, Teruo Tanaka

    Cell and tissue research   325 ( 1 )   47 - 54   2006.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-006-0183-7

  • Capsaicin receptor expression in the rat temporomandibular joint. Reviewed International journal

    Ioi H, Kido MA, Zhang JQ, Yamaza T, Nakata S, Nakasima A, Tanaka T

    Cell and tissue research   325 ( 1 )   47 - 54   2006.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Capsaicin receptor expression in the rat temporomandibular joint.
    Experimentally, temporomandibular joint (TMJ) nerve units respond to capsaicin, which is used clinically to treat TMJ pain. However, the existence of capsaicin receptors in the TMJ has not previously been clearly demonstrated. Immunohistochemical analysis has revealed the presence of transient receptor potential vanilloid subtype 1 (TRPV1) expression in the nerves and synovial lining cells of the TMJ. TRPV1-immunoreactive nerves are distributed in the synovial membrane of the joint capsule and provide branches to the joint compartment. The disc periphery is supplied by TRPV1 nerves that are mostly associated with small arterioles, and occasional nerves penetrate to the synovial lining layer. Double immunofluorescence has shown that many TRPV1-immunoreactive nerves are labeled with neuropeptide calcitonin gene-related peptide, whereas few are labeled with IB4-lectin. The results provide evidence for the presence of TRPV1 in both nerves and synovial lining cells, which might thus be involved in the mechanism of nociception and inflammation in the TMJ.

    DOI: 10.1007/s00441-006-0183-7

  • Immunocytochemical localization of the neurokinin 1 receptor in rat dental pulp Reviewed

    Mizuho A. Kido, Teiichi Ibuki, Atsushi Danjo, Teruyoshi Kondo, Jing Qi Zhang, Takayoshi Yamaza, Yoshio Yamashita, Yoshinori Higuchi, Teruo Tanaka

    Archives of Histology and Cytology   68 ( 4 )   259 - 265   2005.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1679/aohc.68.259

  • Immunocytochemical localization of the neurokinin 1 receptor in rat dental pulp. Reviewed

    Kido MA, Ibuki T, Danjo A, Kondo T, Zhang JQ, Yamaza T, Yamashita Y, Higuchi Y, Tanaka T

    Archives of histology and cytology   68 ( 4 )   259 - 265   2005.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Immunocytochemical localization of the neurokinin 1 receptor in rat dental pulp.
    The dentin-pulp complex is a peripheral end-organ supplied by dense sensory nerve fibers. Substance P, a representative neuropeptide widely distributed in the dental pulp, has been reported to play roles in pain transmission and the amplification of inflammation. We analyzed here the expression of the neurokinin 1 (NK1) receptor, preferentially activated by substance P, using immunocytochemistry in rat dental pulp at both the light and electron microscopic levels. Conspicuous NK1 receptor immunoreactivity was found in the odontoblasts; immunolabelings were present at their plasma membrane and endosomal structures, especially in their cytoplasmic processes. Immunoreactions for NK1 receptor were also detectable in a part of the nerve terminals associated with the cytoplasmic processes of the odontoblasts. Furthermore, the endothelial cells of capillaries and post-capillary venules and the fibroblasts were labeled with the NK1 receptor in the subodontoblast layer. These findings suggest that pulpal cells and nerve fibers are targets for substance P that mediate multiple functions, including a vasoactive function and the regulation of vascular permeability as well as the modulation of pain transmission.

  • Ultrastructural localization of laminin-5 (γ2 chain) in the rat peri-implant oral mucosa around a titanium-dental implant by immuno-electron microscopy Reviewed

    26 ( 32 )   6280 - 6287   2005.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Laminin-5 (Ln-5) is an important molecule associated with epithelial cell adhesion and migration. In the gingiva around the tooth, Ln-5 localizes within basement membranes between the junctional epithelium (JE) and the tooth or connective tissue. Recently, we reported that in the oral mucosa around a dental implant, Ln-5 is expressed within the basement membranes at the implant-peri-implant epithelium (PIE) interface, and at the PIE-connective tissue interface. However, the ultrastructural localization of Ln-5 within or along the PIE has not yet been reported. Therefore, peri-implant oral mucosa was treated with anti-Ln-5 (γ2 chain) antibody and examined using immuno-electron microscopy. Ln-5 was localized in the cells of the innermost-third layer and basal layer of the PIE. A 100-nm-wide Ln-5-positive internal basal lamina (basement membrane) and hemidesmosomes as adhesion structures were formed at the apical portion of the implant-PIE interface. However, at the upper-middle portion of the interface, these adhesion structures were not observed. Furthermore, at the PIE-connective tissue interface, the Ln-5-positive external basal lamina (basement membrane) and hemidesmosomes were partially deficient. Judging from these findings, we concluded that Ln-5 contributes to the attachment of the PIE to the titanium surface, and that PIE attached to titanium at the apical portion of the dental implant-PIE interface.

    DOI: 10.1016/j.biomaterials.2005.03.046

  • Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats Reviewed

    Ikiru Atsuta, Takayoshi Yamaza, Masao Yoshinari, Satoya Mino, Tetsuya Goto, Mizuho A. Kido, Yoshihiro Terada, Teruo Tanaka

    Biomaterials   26 ( 14 )   1751 - 1760   2005.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2004.05.033

  • Localization of the endogenous cysteine proteinase inhibitor, cystatin C, and the cysteine proteinase, cathepsin B, to the junctional epithelium in rat gingiva Reviewed

    Takayoshi Yamaza, Satoya Mino, Ikiru Atsuta, Atsushi Danjo, Tadayoshi Kagiya, Katsushi Nishijima, Jin Qi Zang, Mizuho A. Kido, Teruo Tanaka

    Acta Histochemica et Cytochemica   38 ( 2 )   121 - 129   2005.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1267/ahc.38.121

  • Expression of osteocalcin and Jun D in the early period during reactionary dentin formation after tooth preparation in rat molars Reviewed

    Masako Hirata, Takayoshi Yamaza, Yu Feng Mei, Akifumi Akamine

    Cell and tissue research   319 ( 3 )   455 - 465   2005.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-004-1035-y

  • Expression of osteocalcin and Jun D in the early period during reactionary dentin formation after tooth preparation in rat molars Reviewed International journal

    M Hirata, T Yamaza, YF Mei, A Akamine

    CELL AND TISSUE RESEARCH   319 ( 3 )   455 - 465   2005.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-004-1035-y

  • The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats Reviewed

    Hiroshi Kajiwara, Takayoshi Yamaza, Masao Yoshinari, Tetsuya Goto, Shinji Iyama, Atsuta Ikiru, Mizuho A. Kido, Teruo Tanaka

    Biomaterials   26 ( 6 )   581 - 587   2005.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2004.02.072

  • ラット顎関節におけるカプサイシン受容体陽性神経の分布

    宮嵜 由美子, 冨岡 千佳, 古田 由梨子, 城戸 瑞穂, 山座 孝義, 角 静香, 田中 輝男

    柔道整復・接骨医学 = Japanese journal [of] judo therapy   13 ( 3 )   312 - 312   2004.12

     More details

    Language:Japanese  

  • カプサイシン口腔投与により活性化されるERK神経の解析

    城戸 瑞穂, 張 施旗, 山座 孝義, 田中 輝男

    46 ( 5 )   395 - 395   2004.9

     More details

    Language:Japanese  

  • 破骨細胞におけるIba1の局在

    山座 孝義, 鍵谷 忠慶, 熱田 生, 城戸 瑞穂, 田中 輝男

    46 ( 5 )   405 - 405   2004.9

     More details

    Language:Japanese  

  • チタンへの口腔粘膜上皮細胞の接着に対するインスリン様増殖因子-1(IGF-1)の効果

    熱田 生, 山座 孝義, 吉成 正雄, 城戸 瑞穂, 寺田 善博, 田中 輝男

    46 ( 5 )   456 - 456   2004.9

     More details

    Language:Japanese  

  • Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat Reviewed

    T. Yamaza, K. F. Masuda, I. Atsuta, K. Nishijima, M. A. Kido, T. Tanaka

    Journal of Dental Research   83 ( 8 )   619 - 624   2004.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/154405910408300807

  • Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat Reviewed

    T Yamaza, KF Masuda, Atsuta, I, K Nishijima, MA Kido, T Tanaka

    JOURNAL OF DENTAL RESEARCH   83 ( 8 )   619 - 624   2004.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cathepsins in the osteoclast Reviewed

    Tetsuya Goto, Takayoshi Yamaza, Teruo Tanaka

    Journal of Electron Microscopy   52 ( 6 )   551 - 558   2003.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jmicro/52.6.551

  • 破骨細胞の膜輸送過程におけるPI3キナーゼの関与について

    山座 孝義, 熱田 生, 鍵谷 忠慶, 室谷 春江, 城戸 瑞穂, 後藤 哲哉, 田中 輝男

    歯科基礎医学会雑誌   45 ( 5 )   341 - 341   2003.9

     More details

    Language:Japanese  

  • Vanilloid receptor expression in the rat tongue and palate Reviewed

    M. A. Kido, H. Muroya, T. Yamaza, Y. Terada, T. Tanaka

    Journal of Dental Research   82 ( 5 )   393 - 397   2003.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/154405910308200513

  • Vanilloid receptor expression in the rat tongue and palate

    MA Kido, H Muroya, T Yamaza, Y Terada, T Tanaka

    JOURNAL OF DENTAL RESEARCH   82 ( 5 )   393 - 397   2003.5

     More details

    Language:English  

  • Phosphatidylinositol-3 kinase plays a role in vesicle transport in the secretory pathway of cathepsin K and cystatin C in osteoclasts

    T Yamaza, Atsuta, I, Y Tsuji, T Goto, T Tanaka

    BONE   32 ( 5 )   S148 - S148   2003.5

     More details

    Language:English   Publishing type:Research paper (other academic)  

  • NF-κB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis Reviewed

    82 ( 3 )   183 - 188   2003.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    NF-κB plays a pivotal role in pathogenesis in general arthritis. However, the participation of NF-κB in inflammation of the temporomandibular joint (TMJ) is poorly understood. We examined NF-κB expression in rat TMJs with synovitis induced by condyle hypermobility. By immunohistochemistry, NF-κB immunoreactivity was found mainly in the cytoplasm, not the nucleus, of the synovial lining cells of induced-synovitis and control TMJs. Southwestern histochemistry, a new method for detecting transcription factors, showed greater NF-κB expression in the nucleus of the synovial lining cells in the hypertrophic synovium than in control synovium. Increased numbers of the synovial lining cells with immunoreactivity for inducible nitric oxide synthase (iNOS), which is transcriptionally regulated by NF-κB, were also seen in the inflamed synovium. These findings indicate that excess mechanical stress increases NF-κB activation in the TMJ and suggest that active NF-κB is involved in the progression of TMJ inflammation.

    DOI: 10.1177/154405910308200307

  • NF-kB Activation and iNOS Expression in the Synovial Membrane of Rat Temporomandibular Joints after Induced Synovitis

    YAMAZA T., MASUDA K.F., TSUKIYAMA Y., NISHIJIMA K., MURAKAMI R., KIDO M.A., KOYANO K., TANAKA T.

    Journal of dental research   82 ( 3 )   183 - 188   2003.3

     More details

    Language:English  

    NF-kB Activation and iNOS Expression in the Synovial Membrane of Rat Temporomandibular Joints after Induced Synovitis

  • Biological characteristics of the junctional epithelium Reviewed

    Masaki Shimono, Tatsuya Ishikawa, Yasunobu Enokiya, Takashi Muramatsu, Ken Ichi Matsuzaka, Takashi Inoue, Yoshihiro Abiko, Takayoshi Yamaza, Mizuho A. Kido, Teruo Tanaka, Sadamitsu Hashimoto

    Journal of Electron Microscopy   52 ( 6 )   627 - 639   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jmicro/52.6.627

  • インプラント体周囲粘膜上皮の形成過程におけるラミニン5の発現

    熱田 生, 山座 孝義, 吉成 正雄, 白岩 昌, 室谷 春江, 城戸 瑞穂, 寺田 善博, 田中 輝男

    歯科基礎医学会雑誌   44 ( 5 )   391 - 391   2002.9

     More details

    Language:Japanese  

  • 破骨細胞におけるカテプシンKおよびシスタチンCの遺伝子ならびに動態

    山座 孝義, 辻 康夫, 熱田 生, 室谷 春江, 後藤 哲哉, 田中 輝男

    歯科基礎医学会雑誌   44 ( 5 )   397 - 397   2002.9

     More details

    Language:Japanese  

  • Difference in penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant or junctional epithelium of rat gingivae Reviewed

    Hidehiro Ikeda, Masaru Shiraiwa, Takayoshi Yamaza, Masao Yoshinari, Mizuho A. Kido, Yasunori Ayukawa, Takashi Inoue, Kiyoshi Koyano, Teruo Tanaka

    Clinical Oral Implants Research   13 ( 3 )   243 - 251   2002.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1034/j.1600-0501.2002.130303.x

  • Difference in penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant or junctional epithelium of rat gingivae International journal

    H Ikeda, M Shiraiwa, T Yamaza, M Yoshinari, MA Kido, Y Ayukawa, T Inoue, K Koyano, T Tanaka

    CLINICAL ORAL IMPLANTS RESEARCH   13 ( 3 )   243 - 251   2002.6

     More details

    Language:English  

    DOI: 10.1034/j.1600-0501.2002.130303.x

  • Distribution of inducible nitric oxide synthase, interleukin-1β, and interleukin-1 receptor in the temporomandibular joint of normal rats Reviewed

    35 ( 1 )   11 - 21   2002.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Nitric oxide (NO) is generated from L-arginine by NO synthase (NOS) and has multiple functions under both physiological and pathological conditions. One isoform of NOS, inducible NOS (iNOS) is expressed in the cells such as macrophages after induction with various cytokines or mechanical stress. In this study, we investigated the distribution of iNOS, interleukin-1β (IL-1β) and its receptor, the IL-1 receptor (IL-1R), in the synovial membrane of the temporomandibular joint (TMJ) of normal rats using immunolight and immunoelectron microscopy. By light microscopy, an immunopositive reaction for iNOS and IL-1β was found in the superficial cells of the synovial membrane of both the anterior and posterior portions of the articular disc. Immunoelectron microscopy revealed that iNOS-immunoreactive products were deposited in the cytoplasm and vesicles, and on the plasma membrane of type-A (macrophage-like) and B (fibroblast-like) cells of the superficial layer. IL-1R-positive products were found both on the plasma membrane and in the vesicles of type-A cells of the synovial lining, and were observed in macrophages in the sublining layer. These results reveal that iNOS and IL-1β localize to the synovial membrane of the rat TMJ under physiological conditions. Therefore, it is likely that autocrine/paracrine effects of IL-1β induce NO generation by iNOS via the IL-1R in type-A cells. It is considered that cytokine-induced NO may play an important role in the physiological maintenance, e.g. self-protection, by synovial lining cells of the synovial membrane in the TMJ.

    DOI: 10.1267/ahc.35.11

  • 顎関節炎モデルラットにおける反応性窒素酸化物の炎症増悪への関与

    深蔵啓太郎, 山座孝義, 城戸瑞穂, 築山能大, 古谷野潔, 田中輝男

    日本顎関節学会雑誌   14 ( 1 )   107 - 108   2002.4

     More details

    Language:Japanese  

  • Substance P and substance P receptors in bone and gingival tissues Reviewed

    T. Goto, Mizuho A. Kido, Takayoshi Yamaza, Teruo Tanaka

    Medical Electron Microscopy   34 ( 2 )   77 - 85   2001.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s007950170001

  • Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy

    T Yamaza, Y Tsuji, T Goto, MA Kido, K Nishijma, R Moroi, A Akamine, T Tanaka

    BONE   29 ( 1 )   42 - 53   2001.7

     More details

    Language:English  

    DOI: 10.1016/S8756-3282(01)00466-5

  • Topography and distribution of sympathetic nerve fibers in the rat temporomandibular joint Immunocytochemistry and ultrastructure Reviewed

    Mizuho A. Kido, Jing Qi Zhang, Harue Muroya, Takayoshi Yamaza, Yoshihiro Terada, Teruo Tanaka

    Anatomy and Embryology   203 ( 5 )   357 - 366   2001.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004290100163

  • Topography and distribution of sympathetic nerve fibers in the rat temporomandibular joint: immunocytochemistry and ultrastructure

    MA Kido, JQ Zhang, H Muroya, T Yamaza, Y Terada, T Tanaka

    ANATOMY AND EMBRYOLOGY   203 ( 5 )   357 - 366   2001.5

     More details

    Language:English  

    DOI: 10.1007/s004290100163

  • Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy Reviewed

    Yasuo Tsuji, Takayoshi Yamaza, Mizuho A. Kido, Tetsuya Goto, Shunsuke Nakata, Akifumi Akamine, Akihiko Nakasima, Teruo Tanaka

    Cell and tissue research   303 ( 3 )   359 - 369   2001.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004410000327

  • 歯根周囲組織における破骨細胞分化因子の局在に関する免疫組織学的研究

    小笠原 貴子, 吉嶺 嘉人, 山座 孝義, 橋口 勇, 中野 嗣久, 赤峰 昭文

    日本歯科保存学雑誌   44   97 - 97   2001.4

     More details

    Language:Japanese  

  • Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy

    Y Tsuji, T Yamaza, MA Kido, T Goto, S Nakata, A Akamine, A Nakasima, T Tanaka

    CELL AND TISSUE RESEARCH   303 ( 3 )   359 - 369   2001.3

     More details

    Language:English  

    DOI: 10.1007/s004410000327

  • An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2000 Reviewed

    Isamu Hashiguchi, Takayoshi Yamaza, Y. Koishi, Yasuharu Goto, Yoshimine Yoshito, A. Akamine, H. Fukuyama, H. Okumura

    Fukuoka igaku zasshi = Hukuoka acta medica   92 ( 5 )   115 - 119   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Substance P activates osteoclast formation and osteoclastic bene resorption through the neurokinin-1 receptor Reviewed

    Tetsuya Goto, Takayoshi Yamaza, Mizuho A. Kido, Teruo Tanaka

    Acta Histochemica et Cytochemica   34 ( 1 )   31 - 38   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1267/ahc.34.31

  • Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy Reviewed

    T. Yamaza, Y. Tsuji, T. Goto, M. A. Kido, K. Nishijima, R. Moroi, A. Akamine, T. Tanaka

    Bone   29 ( 1 )   42 - 53   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S8756-3282(01)00466-5

  • Substance P activates osteoclast formation and osteoclastic bene resorption through the neurokinin-1 receptor Reviewed

    Tetsuya Goto, Takayoshi Yamaza, Mizuho A. Kido, Teruo Tanaka

    Acta Histochemica et Cytochemica   34 ( 1 )   31 - 38   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1267/ahc.34.31

  • 破骨細胞性骨吸収過程におけるPI3-キナーゼの関与について

    西田 浩史, 山座 孝義, 山下 英俊, 橋口 勇, 小石 裕子, 小笠原 貴子, 吉嶺 嘉人, 中牟田 博敬, 赤峰 昭文

    日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY   43   161 - 161   2000.10

     More details

    Language:Japanese  

  • Ultrastructural and immunoelectron microscopic studies of the peri-implant epithelium-implant (Ti-6Al-4V) interface of rat maxilla

    H Ikeda, T Yamaza, M Yoshinari, Y Ohsaki, Y Ayukawa, MA Kido, T Inoue, M Shimono, K Koyano, T Tanaka

    JOURNAL OF PERIODONTOLOGY   71 ( 6 )   961 - 973   2000.6

     More details

    Language:English  

  • Ultrastructural and Immunoelectron Microscopic Studies of the Peri-Implant Epithelium-Implant (Ti-6Al-4V) Interface of Rat Maxilla Reviewed

    Hidehiro Ikeda, Takayoshi Yamaza, Masao Yoshinari, Yasuyoshi Ohsaki, Yasunori Ayukawa, Mizuho A. Kido, Takashi Inoue, Masaki Shimono, Kiyoshi Koyano, Teruo Tanaka

    Journal of Periodontology   71 ( 6 )   961 - 973   2000.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1902/jop.2000.71.6.961

  • Ultrastructural and Immunoelectron Microscopic Studies of the Peri-Implant Epithelium-Implant (Ti-6Al-4V) Interface of Rat Maxilla Reviewed

    Hidehiro Ikeda, Takayoshi Yamaza, Masao Yoshinari, Yasuyoshi Ohsaki, Yasunori Ayukawa, Mizuho A. Kido, Takashi Inoue, Masaki Shimono, Kiyoshi Koyano, Teruo Tanaka

    Journal of Periodontology   71 ( 6 )   961 - 973   2000.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1902/jop.2000.71.6.961

  • インプラント周囲上皮とその界面における閉鎖性に関する研究

    池田英弘, 山座孝義, 吉成正雄, 鮎川保則, 古谷野潔, 田中輝男

    日本バイオマテリアル学会大会予稿集   21st   101   1999.11

     More details

    Language:Japanese  

  • Immunocytochemical localization of substance P neurokinin-1 receptors in rat gingival tissue Reviewed

    Mizuho A. Kido, Takayoshi Yamaza, Tetsuya Goto, Teruo Tanaka

    Cell and tissue research   297 ( 2 )   213 - 222   1999.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004410051349

  • Immunocytochemical localization of substance P neurokinin-1 receptors in rat gingival tissue

    MA Kido, T Yamaza, T Goto, T Tanaka

    CELL AND TISSUE RESEARCH   297 ( 2 )   213 - 222   1999.8

     More details

    Language:English  

    DOI: 10.1007/s004410051349

  • 破骨細胞におけるシステインプロテアーゼインヒビター、シスタチンCの局在

    山座 孝義, 後藤 哲哉, 赤峰 昭文, 田中 輝男

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism   17 ( 2 )   107 - 107   1999.6

     More details

    Language:Japanese  

  • Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur Reviewed

    T. Yamaza, T. Goto, T. Kamiya, Y. Kobayashi, H. Sakai, T. Tanaka

    Bone   23 ( 6 )   499 - 509   1998.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S8756-3282(98)00138-0

  • Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur

    T Yamaza, T Goto, T Kamiya, Y Kobayashi, H Sakai, T Tanaka

    BONE   23 ( 6 )   499 - 509   1998.12

     More details

    Language:English  

    DOI: 10.1016/S8756-3282(98)00138-0

  • Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone Reviewed

    Tetsuya Goto, Takayoshi Yamaza, Mizuho A. Kido, Teruo Tanaka

    Cell and tissue research   293 ( 1 )   87 - 93   1998.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004410051100

  • Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone Reviewed

    Tetsuya Goto, Takayoshi Yamaza, Mizuho A. Kido, Teruo Tanaka

    Cell and tissue research   293 ( 1 )   87 - 93   1998.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004410051100

  • A fluid-phase endocytotic capacity and intracellular degradation of a foreign protein (horseradish peroxidase) by lysosomal cysteine proteinases in the rat junctional epithelium Reviewed

    T. Yamaza, M. A. Kido, T. Kiyoshima, Y. Nishimura, M. Himeno, T. Tanaka

    Journal of Periodontal Research   32 ( 8 )   651 - 660   1997.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0765.1997.tb00575.x

  • マトリックスメタロプロテアーゼ阻害剤、KB-R7785、は破骨細胞の migration を抑制する

    後藤 哲哉, 山座 孝義, 田中 輝男

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism   15 ( 2 )   337 - 337   1997.6

     More details

    Language:Japanese  

  • Immunocytochemical study of cathepsin l and rat salivary cystatin-3 in rat osteoclasts treated with e-64 in vivo Reviewed

    Ryoji Moroi, Takayoshi Yamaza, Toshihiro Nishiura, Yukio Nishimura, Yoshihiro Terada, Kimio Abe, Masaru Himeno, Teruo Tanaka

    Archives of Oral Biology   42 ( 4 )   305 - 315   1997.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0003-9969(97)00003-4

  • Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo

    R Moroi, T Yamaza, T Nishiura, Y Nishimura, Y Terada, K Abe, M Himeno, T Tanaka

    ARCHIVES OF ORAL BIOLOGY   42 ( 4 )   305 - 315   1997.4

     More details

    Language:English  

    DOI: 10.1016/S0003-9969(97)00003-4

  • B-25-10 : 10 ラット歯肉付着上皮細胞におけるシステイン・プロテアーゼの局在、および細胞内消化に関する研究 : カテプシンB、Hおよびトレーサーとして西洋ワサビペルオキシダーゼの局在に関する免疫細胞化学的研究

    山座 孝義, 城戸 瑞穂, 田中 輝男

    日本歯周病学会会誌   38   130 - 130   1996.9

     More details

    Language:Japanese  

  • B-26-10 : 20 ラット付着上皮における局所投与サブスタンスPの影響に関する細胞化学的研究

    後藤 康治, 山座 孝義, 城戸 瑞穂, 赤峰 昭文, 田中 輝男

    日本歯周病学会会誌   38   131 - 131   1996.9

     More details

    Language:Japanese  

  • YM175投与ラット破骨細胞におけるカテプシンLの局在およびトレーサーを用いた取り込み能に関する免疫細胞化学(細胞化学)的研究

    山座 孝義, 諸井 亮司, 鮎川 保則, 田中 輝男

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism   14 ( 2 )   311 - 311   1996.6

     More details

    Language:Japanese  

  • Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats Reviewed

    T. Tanaka, M. A. Kido, T. Ibuki, T. Yamaza, T. Kondo, E. Nagata

    Journal of Periodontal Research   31 ( 3 )   187 - 194   1996.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0765.1996.tb00483.x

  • Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats

    T Tanaka, MA Kido, T Ibuki, T Yamaza, T Kondo, E Nagata

    JOURNAL OF PERIODONTAL RESEARCH   31 ( 3 )   187 - 194   1996.4

     More details

    Language:English  

  • An immunohistochemical and monastral blue-vascular labelling study on the involvement of capsaicin-sensitive sensory innervation of the junctional epithelium in neurogenic plasma extravasation in the rat gingiva Reviewed

    T. Kondo, M. A. Kido, T. Kiyoshima, T. Yamaza, T. Tanaka

    Archives of Oral Biology   40 ( 10 )   931 - 940   1995.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/0003-9969(95)00060-3

  • AN IMMUNOHISTOCHEMICAL AND MONASTRAL BLUE-VASCULAR LABELING STUDY ON THE INVOLVEMENT OF CAPSAICIN-SENSITIVE SENSORY INNERVATION OF THE JUNCTIONAL EPITHELIUM IN NEUROGENIC PLASMA EXTRAVASATION IN THE RAT GINGIVA

    T KONDO, MA KIDO, T KIYOSHIMA, T YAMAZA, T TANAKA

    ARCHIVES OF ORAL BIOLOGY   40 ( 10 )   931 - 940   1995.10

     More details

    Language:English  

  • B-25-14 : 50 ラット付着上皮内サブスタンスP及びカルシトニン遺伝子関連ペプチド含有神経について : 共焦点レーザー顕微鏡と電子顕微鏡による観察

    城戸 瑞穂, 山座 孝義, 坂井 貴子, 寺田 善博, 田中 輝男

    日本歯周病学会会誌   37   115 - 115   1995.9

     More details

    Language:Japanese  

  • E-64投与ラット破骨細胞におけるカテプシンLおよびI型コラーゲンの局在に関する免疫細胞化学的研究

    諸井 亮司, 鮎川 保則, 山座 孝義, 田中 輝男

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism   13 ( 2 )   228 - 228   1995.7

     More details

    Language:Japanese  

  • チタニウムコートインプラントを用いた骨-チタニウム界面の超微細構造

    鮎川 保則, 諸井 亮司, 山座 孝義, 田中 輝男

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism   13 ( 2 )   214 - 214   1995.7

     More details

    Language:Japanese  

  • The Changes in the Immunocytochemical Localization of Cathepsin L and Type I Collagen in Rat Osteoclasts Treated with E-64 Reviewed

    Ryoji Moroi, Takayoshi Yamaza, Yasunori Ayukawa, Tamotsu Kiyoshima, Yasuyoshi Ohsaki, Yukio Nishimura, Yoshihiro Terada, Masaru Himeno, Teruo Tanaka

    Acta Histochemica et Cytochemica   28 ( 6 )   523 - 531   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1267/ahc.28.523

▼display all

Books

  • Properties and possibilities of human dental pulp-derived stem cells.

    Soichiro Sonoda, Erika Tomoda, Yosuke Tanaka, Takayoshi Yamaza( Role: Joint author)

    SciMedCentral  2015.7 

     More details

    Responsible for pages:2(2):1012   Language:English   Book type:Scholarly book

  • 4.歯髄幹細胞の最近の知見  口腔組織学・発生学 第2版  第Ⅱ偏口腔組織・発生学各論  第四章象牙質・歯髄複合体  Ⅴ臨床的考察

    山座 孝義( Role: Sole author)

    医歯薬出版  2015.2 

     More details

    Responsible for pages:pp130-135   Language:Japanese   Book type:Scholarly book

  • Chaptor 8. Multipotent Stem Cells in Dental Pulp. In Culture of Human Stem Cells (Ed Stacey GN, Freshney RI, Auerbach JM)

    Sonoyama W, Yamaza T, Gronthos S, Shi S.( Role: Joint author)

    Wiley  2007.7 

     More details

    Responsible for pages:pp. 187-206.   Language:English   Book type:Scholarly book

  • 組織学・口腔組織学

    安部 仁晴, 磯川 桂太郎 , 稲井 哲一朗, 野中 直子, 本田 雅規, 山座 孝義, 山本 仁 (形態系基礎歯科学)

    わかば出版  2024    ISBN:9784898240946

     More details

    Language:Japanese  

    CiNii Books

  • Chapter 10. Biological Sealing and Defense Mechanisms in Peri-Implant Mucosa of Dental Implants. Implant Dentistry - The Most Promising Discipline of Dentistry. Editedd by Ilser Turkyilmaz.

    Takayoshi Yamaza, Mizuho A. Kido( Role: Joint author)

    InTech  2011.10 

     More details

    Responsible for pages:pp220-242.   Language:English   Book type:Scholarly book

  • 『顎関節症』(日本顎関節学会編) 微細構造(特に滑膜組織について).

    田中輝男,山座孝義( Role: Joint author)

    永末書店  2003.3 

     More details

    Responsible for pages:361-365   Language:Japanese   Book type:Scholarly book

▼display all

Presentations

  • Long Term Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Utilize for a Feasible Stem Cell Resource for Regenerative Medicine International conference

    Ma Lan, Yamaza Haruyoshi, Akiyama Kentaro, Song Guangtai, Kukita Toshio, Shi Songtao, Nonaka Kazuaki, Yamaza Takayoshi

    Gordon Reserch Conference, Biomaterials and tissue engineering  2012.7 

     More details

    Event date: 2012.7 - 2012.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 歯髄幹細胞の特性と再生医療への応用 Invited

    山座 孝義、吉丸耕一朗、田口智章

    第18回 日本再生医療学会総会 SY10消化管の再生医療  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • 乳歯幹細胞の単離時に血清濃度が与える影響について

    園田 聡一朗、大谷 憲司、山座 孝義

    第60回日本歯科基礎医学会総会  2018.9 

     More details

    Event date: 2018.9 - 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 乳歯幹細胞による骨再生 アップデートシンポジウム10骨改造の新局面:骨吸収から骨形成・骨再生への橋渡し機構を探る Invited

    山座孝義

    第60回日本歯科基礎医学会総会  2018.9 

     More details

    Event date: 2018.9 - 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 外因性の一酸化窒素刺激は歯髄幹細胞の象牙芽細胞分化を促進する

    園田聡一朗, 山座孝義, 西村英紀

    歯科保存学会2018春季大会  2018.6 

     More details

    Event date: 2018.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • ヒルシュスプルング病類縁疾患に対する乳歯歯髄幹細胞を用いた腸管神経再生医療 Invited

    吉丸耕一朗、山座孝義、梶岡俊一、高橋良彰、柳祐典、松浦俊治、小田義直、田口智章

    第33回日本小児外科学会  2017.10 

     More details

    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:川崎   Country:Japan  

  • 乳歯歯髄幹細胞を用いた腸管神経再生による先天性腸管蠕動不全に対する新規治療法の開発

    吉丸耕一朗, 山座孝義, 梶岡俊一, 高橋良彰, 柳佑典, 松浦俊治, 小田義直, 田口智章

    第44回小児栄養消化器肝臓学会  2017.10 

     More details

    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 乳歯幹細胞と肝再生 Invited

    山座孝義

    第44回小児栄養消化器肝臓学会  2017.10 

     More details

    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 九州大学歯学部における実習手順−顔面と口腔、側頭下窩・口蓋− Invited

    山座孝義

    第122回日本解剖学会総会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • 小児領域の難病治療における歯髄幹細胞療法の可能性

    田口 智章 先生、栁 佑典、吉丸耕一朗、松浦俊治、山座孝義、山座治義、野中和明

    第23回産学連携フォーラム  2016.10 

     More details

    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 一酸化窒素によるラット歯髄幹細胞の象牙芽細胞分化促進

    園田聡一朗, 山座孝義, 久木田敏夫

    第58回歯科基礎医学会学術大会  2016.8 

     More details

    Event date: 2016.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • ヒト乳歯幹細胞におけるビリルビン添加による細胞生存への影響

    友田恵利佳、山座孝義、山座治義、田中陽介、園田聡一朗、野中和明、久木田敏夫

    第58回歯科基礎医学会学術大会  2016.8 

     More details

    Event date: 2016.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • 根尖乳頭組織由来幹細胞の象牙質形成に対するアスピリンの影響

    田中陽介、山座孝義、友田恵利佳、園田聡一朗、上原範久、久本由香里、久木田敏夫

    第58回歯科基礎医学会学術大会  2016.8 

     More details

    Event date: 2016.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • 不可逆性歯髄炎組織由来歯髄幹細胞を応用した象牙質/歯髄複合体の再生

    園田聡一朗, 山座孝義, 西村英紀

    第144回日本歯科保存学会春季学術大会  2016.6 

     More details

    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:栃木   Country:Japan  

  • 体性幹細胞を用いたヒルシュスプルング病とその類縁疾患の新規治療法の開発

    吉丸耕一朗、山座孝義、梶岡俊一、田口智章

    第116回日本外科学会  2016.4 

     More details

    Event date: 2016.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • ヒト脱落乳歯歯髄幹細胞を用いた腸管神経節僅少症に対する腸管神経再生医療

    吉丸耕一朗、山座孝義、梶岡俊一、高橋良彰、柳祐典、松浦俊治、山座治義、小田義直、野中和明、田口智章

    第118回日本外科学会  2018.4 

     More details

    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 肝移植に代わる治療手段としての乳歯歯髄幹細胞移植

    田口 智章, 栁 佑典, 吉丸 耕一朗, 松浦 俊治, 山座 孝義, 山座 治義, 野中 和明

    第15回日本再生医療学会総会  2016.3 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 先天性機能的腸管不全に対する間葉系幹細胞を用いた新規治療法の開発 International conference

    吉丸耕一朗,山座孝義,梶岡俊一,高橋良彰,栁 佑典,松浦俊治,田口智章

    第28回小腸移植研究会  2016.3 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Patient-derived dental pulp stem cells based regeneration of dentin/pulp-complex International conference

    2016.2 

     More details

    Event date: 2016.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 炎症性サイトカイン刺激による不可逆性歯髄炎組織由来歯髄幹細胞の象牙質形成能ならびに免疫抑制能の改善

    園田聡一朗, 山座孝義, 西村英紀

    日本歯周病学会九州五大学・日本臨床歯周病学会九州支部 合同研修会  2015.11 

     More details

    Event date: 2015.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Interferon-gamma improves impaired dentinogenic function and immunosuppressive properties in irreversible pulpitis-derived human dental pulp stem cells. International conference

    Sonoda S, Tomoda E, Tanaka Y, Nishimura F, Yamaza T.

    The 63rd Annual Meeting of Japanese Association for Dental Research.  2015.10 

     More details

    Event date: 2015.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Can irreversible inflamed dental pulp-derived dental pulp stem cells be suitable for dental pulp regeneration?

    Sonoda S, Yamaza T, Kukita T.

    2015.9 

     More details

    Event date: 2015.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 歯髄幹細胞と橋渡し研究 Invited

    山座孝義

    サテライトシンポジウム7 「歯髄間葉系幹細胞の最先端研究」 第57回歯科基礎医学会  2015.9 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:新潟   Country:Japan  

  • Mesenchymal stem cells from deciduous teeth-based liver regeneration Invited

    Takayoshi Yamaza

    2015.7 

     More details

    Event date: 2015.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 間葉系幹細胞誘導性インプラント周囲粘膜の構築 Invited

    熱田 生、鮎川 保則、山座 孝義、近藤 綾介、松浦 由梨、古谷野 潔

    サテライトシンポジウム7 「間葉系幹細胞の直接的・間接的な組織再生への関与を考える」 第56回歯科基礎医学会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ビリルビン影響下におけるヒト歯髄幹細胞の機能回復

    星野慶弘、山座孝義、馬蘭、友田恵利佳、山座治義、野中和明

    第56回 歯科基礎医学会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 間葉系幹細胞移植におけるレシピエントの組織・細胞の反応 Invited

    山座孝義

    サテライトシンポジウム7 「間葉系幹細胞の直接的・間接的な組織再生への関与を考える」 第56回歯科基礎医学会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 乳歯幹細胞とトランスレーショナルメディシン Invited

    山座 孝義

    九州大学母子総合研究リサーチカンファレンス  2014.6 

     More details

    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 口腔幹細胞とトランスレーショナルメディシン Invited

    山座 孝義

    シンポジウム 1 口腔組織に由来する幹細胞の医科への応用 第68回日本口腔科学学会  2014.5 

     More details

    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 四塩化炭素誘導肝硬変モデルマウスに対するヒト脱落乳歯幹細胞移植療法の有効性に関する研究

    柳 佑典, Alatas, Fastima Safira, 吉丸 耕一朗, 林田 真, 大賀 正一, 山座 治義, 山座 孝義, 田口 智章

    第51回日本小児外科学会  2014.5 

     More details

    Event date: 2014.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 口腔幹細胞の未来志向 Invited

    山座 孝義

    九州大学共進化社会システム創成拠点フォーラム  2014.3 

     More details

    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 歯髄幹細胞の特性と再生医療への応用 Invited

    山座 孝義

    第13回 日本再生医療学会  2014.3 

     More details

    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Dental Stem Cell-based Translational Medicine International conference

    Takayoshi Yamaza

    Kyudai Oral Bioscience 2014 -8th International Symposium-  2014.2 

     More details

    Event date: 2014.2 - 2014.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 膜ナノチューブを介する破骨前駆細胞間融合の走査電顕的解析

    張旌旗、高橋良、久木田明子、成松加奈子、上原範久、山座孝義、城戸瑞穂、久木田敏夫

    第55回 歯科基礎医学会  2013.9 

     More details

    Event date: 2013.9 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • Expression of erythropoietin receptor on stem cells from exfoliated deciduous teeth

    2013.9 

     More details

    Event date: 2013.9 - 2023.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 矯正的歯の移動におけるアレルギー誘導性歯根吸収促進機構

    村田直久、五百井秀樹、大内雅博、合島怜央奈、沖雄二、山座孝義、高橋一郎、城戸瑞穂

    第55回 歯科基礎医学会  2013.9 

     More details

    Event date: 2013.9 - 2023.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  • ヒト歯髄幹細胞に対するビリルビンの影響

    星野慶弘、山座孝義、馬蘭、山座治義、野中和明

    第55回 歯科基礎医学会  2013.9 

     More details

    Event date: 2013.9 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 歯周炎患者歯周靭帯由来幹細胞の免疫調節能に対するエリスロポイエチンの影響

    増田啓太郎、山座孝義、馬蘭、星野慶弘、樋口勝規、久木田敏夫

    第55回 歯科基礎医学会  2013.9 

     More details

    Event date: 2013.9 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 凍結ヒト歯髄組織の臨床応用の可能性 Invited

    山座孝義

    サテライトシンポジウム5 「口腔組織幹細胞の未来志向」〜歯髄細胞は臨床応用可能か? 第55回歯科基礎医学会  2013.9 

     More details

    Event date: 2013.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • Cryopreservation of Dental Pulp Tissues of Exfoliated DeciduousTeeth is a Suitable Stem Cell Bank for Regenerative Medicine International conference

    Lan Ma, Haruyoshi Yamaza, Yoshihiro Hoshino, Toshio Kukita, Kazuaki Nonaka, Takayoshi Yamaza

    2013.8 

     More details

    Event date: 2013.8 - 2023.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 歯髄幹細胞による免疫細胞療法 Invited

    山座 孝義

    第34回 日本炎症・再生医学会  2013.7 

     More details

    Event date: 2013.7 - 2014.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Trans-Differentiation and Spheroid Formation of Hepatocyte-Like Cells of Stem Cells from Human Exfoliated Deciduous Teeth International conference

    Fatima Safira Alatas, Takayoshi Yamaza, Haruyoshi Yamaza, Toshio Kukita, Kazuaki Nonaka, Shouichi Ohga, Tomoaki Taguchi

    4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition  2012.11 

     More details

    Event date: 2012.11

    Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • 歯周炎患者歯周靭帯由来幹細胞に対するエリスロポイエチンの影響

    増田啓太郎、山座孝義、馬蘭、牧野友祐、星野慶弘、樋口勝規、久木田敏夫

    第54回 歯科基礎医学会  2012.9 

     More details

    Event date: 2012.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:郡山   Country:Japan  

  • 歯髄幹細胞による免疫療法 Invited

    山座孝義

    サテライトシンポジウム1 歯髄組織のパラダイムシフト 第54回歯科基礎医学会  2012.9 

     More details

    Event date: 2012.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:郡山   Country:Japan  

  • Bone regeneration using stem cells from long-term cryopreserved dental pulp tissues of exfoliated deciduous teeth.

    2012.9 

     More details

    Event date: 2012.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Trans-Differentiation and Spheroid Formation of Hepatocyte-Like Cells of Stem Cells from Human Exfoliated Deciduous Teeth International conference

    Fatima Safira Alatas, Yamaza Takayoshi, Yamaza Haruyoshi, Hayashida Makoto, Yanagi Yusuke, Nonaka Kazuaki, Ohga Shouichi, taguchi tomoaki

    2012.8 

     More details

    Event date: 2012.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Transdifferentiation capacity into hepatocyte-like cells of stem cells from human exfoliated deciduous teeth

    Fatima Safira Alatas, Takayoshi Yamaza, Haruyoshi Yamaza, Toshiharu Matsuura, Makoto Hayashida, Yusuke Yanagi, Toshio Kukita, Kazuaki Nonaka, Shouichi Ohga, Tomoaki Taguchi

    2012.5 

     More details

    Event date: 2012.5

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Improvement of dentinogenesis of irreversible pulpitis-derived DPSCs International conference

    So-ichiro Sonoda, Takayoshi Yamaza, Yusuke Makino, La Ma, Toshio Kukita

    The 59th Annual Meeting of Japanese Association for Dental Research  2011.10 

     More details

    Event date: 2011.10

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 歯周炎患者歯周靭帯からの幹細胞の単離と特性解析

    増田啓太郎、山座孝義、牧野友祐、馬蘭、園田総一朗、樋口勝規、久木田敏夫

    第53回歯科基礎医学会  2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:長良川国際会議場   Country:Japan  

  • 間葉系幹細胞による炎症性骨破壊制御

    高野登志雄、李銀姫、久木田明子、山座孝義、高橋良、鮎川保則、古谷野潔、久木田敏夫

    第53回歯科基礎医学会  2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Oral presentation (general)  

    Venue:長良川国際会議場   Country:Japan  

  • 歯の幹細胞を応用した免疫細胞療法学的再生医療 Invited

    山座孝義

    サテライトシンポジウム3 歯の幹細胞 第53回歯科基礎医学会  2011.9 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:岐阜   Country:Japan  

  • 骨および歯周組織におけるTRPV2およびV4の発現解析

    村田直久、大内雅博、大崎康吉、王冰、合島怜央奈、山座孝義、高橋一郎、城戸瑞穂

    第53回歯科基礎医学会  2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:長良川国際会議場   Country:Japan  

  • ヒト過剰歯由来幹細胞の免疫細胞療法について

    牧野友祐、山座孝義、山座治義、馬蘭、園田総一朗、城戸瑞穂、野中和明、寺田善博、久木田敏夫

    第53回歯科基礎医学会  2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Oral presentation (general)  

    Venue:長良川国際会議場   Country:Japan  

  • 乳歯凍結保存法がヒト乳歯幹細胞の免疫調節能に与える影響について

    山座孝義、牧野友祐、山座治義、馬蘭、園田総一朗、増田啓太郎、野中和明、久木田敏夫

    第53回歯科基礎医学会  2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Oral presentation (general)  

    Venue:長良川国際会議場   Country:Japan  

  • Characterization of stem cells isolated from cryopreserved exfoliated deciduous teeth

    2011.10 

     More details

    Event date: 2011.9 - 2011.10

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 小児の上顎正中過剰埋伏歯の歯髄由来間葉系幹細胞の単離とその免疫調節能の解析

    牧野友祐、山座孝義、山座治義、城戸瑞穂、野中和明、寺田義弘、久木田敏夫

    第52回歯科基礎医学会  2010.9 

     More details

    Event date: 2011.9

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Mesenchymal Stem Cells markedly suppressed Inflammatory Bone Destruction in Rats with Adjuvant-induced Arthritis International conference

    Toshio Takano, Yin-ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kiyoshi Koyano, Toshio Kukita,

    2011 Annual Meeting of American Society of Bone and Mineral Research  2011.9 

     More details

    Event date: 2011.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Influence of cryopreservation on the properties of stem cells isolated from cryopreserved exfoliated deciduous teeth International conference

    Lan Ma, Haruyoshi Yamaza, Yusuke Makino, Guangtai Song, Toshio Kukita, Kazuaki Nonaka, Takayoshi Yamaza

    International Symposium Shaping the future of craniofacial sciences and therapeutics  2011.8 

     More details

    Event date: 2011.8

    Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • 間葉系幹細胞による骨破壊制御:アジュバント関節炎モデルラットを用いた解析

    高野登志雄、李銀姫、久木田明子、山座孝義、鮎川保則、古谷野潔、久木田敏夫

    第29回日本骨代謝学会  2011.7 

     More details

    Event date: 2011.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪国際会議場   Country:Japan  

  • 歯は幹細胞の隠れ家か? Invited

    山座孝義

    大阪歯科大学 エンジョイミーティングの会  2011.6 

     More details

    Event date: 2011.6

    Presentation type:Oral presentation (general)  

    Venue:大阪歯科大学   Country:Japan  

  • インプラント周囲粘膜上皮おける生物学的封鎖と防御に関する電子顕微鏡学的解析 Invited

    山座孝義

    日本顕微鏡学会第67回学術講演会 シンポジウム 歯科インプラントの顕微鏡解析  2011.5 

     More details

    Event date: 2011.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Immunomodulatory Properties of Stem Cells from Human Supernumerary Teeth. International conference

    Y. MAKINO, T. YAMAZA, H. YAMAZA, K. AKIYAMA, M. KIDO, K. NONAKA, Y. TERADA, S. SHI, and T. KUKITA.

    89th IADR General Session & Exhibition of IADR  2011.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • ラット歯髄におけるsubstance P (Neurokinin 1) receptorの局在

    伊吹禎一、城戸瑞穂、山座孝義、笹本一茂、寺田善博、田中輝男

    第40回歯科基礎医学会  1998.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Immunohistoochemical localization of inducible nitric oxide synthase and Interleukin-1beta in arthritis of the rat temporomandibular joint induced by trauma. International conference

    Tsukiyama Y, Fukakura K, Yamaza T, Kido M.A., Koyano Y, Tanaka T

    3rd International Congress on Orofacial Pain and Temporomandibular Disorders  2000.5 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • NEUROPEPTIDES in GINGIVA Invited International conference

    Kido M.A., Yamaza T, Goto T, Tanaka T

    Symposium in 1st ROMANIAN CONGRESS OF CELL AND MOLECULAR BIOLOGY with international participation and The 18th Annual Session of Romanian Society of Cell and Molecular Biology  2000.6 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Romania  

  • インプラント治療のための付着上皮再生

    熱田生、山座孝義、城戸瑞穂、田中輝男

    第1回口腔組織の再生の総合的開発研究会、九州大学リサーチコア  2003.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット顎関節、一次知覚神経におけるMAPキナーゼのリン酸化

    城戸瑞穂、五百井秀樹、山座孝義、田中輝男

    第17回日本顎関節学会総会学術大会  2004.7 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Activation of peripheral nerves in oral mucosa by oral capsaicin. International conference

    M. A. Kido, J.Q. Zhang, T. Yamaza T. Tanaka

    In Topics on Oral sensory structure and function.,16th International Federation of Association of Anatomists  2004.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 破骨細胞におけるIbalの局在

    山座孝義、鍵谷忠慶、熱田生、城戸瑞穂、田中輝男

    第46回歯科基礎医学会  2004.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • チタンへの口腔粘膜上皮細胞の接着に対するインスリン様増殖因子1(IGF-1)の効果

    熱田生、山座孝義、吉成正雄、城戸瑞穂、寺田善博、田中輝男

    第46回歯科基礎医学会  2004.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット歯髄におけるTRPV1 およびPKC ipsilon の発現について

    張旌旗、城戸瑞穂、山座孝義、西嶋克司、田中輝男

    第46回歯科基礎医学会  2004.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット顎関節におけるカプサイシン受容体陽性神経の分布

    宮崎由美子、富岡千佳、古田由梨子、城戸瑞穂、山座孝義、角静香、田中輝男

    第14回日本柔道整復接骨医学会  2004.12 

     More details

    Event date: 2011.4

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ラット歯髄および三叉神経節におけるTRPV1およびPKCεの発現について

    張旌旗、城戸瑞穂、山座孝義、西嶋克司、田中輝男

    第110回日本解剖学会  2005.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 口蓋粘膜におけるカプサイシン受容体発現細胞の解析

    城戸瑞穂、張旌旗、山座孝義、田中輝男

    第110回日本解剖学会  2005.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCは骨芽細胞の硬組織形成能を促進する

    檀上敦、山座孝義、鍵谷忠慶、西嶋克司、城戸瑞穂、田中輝男

    第47回歯科基礎医学会  2005.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 舌、口腔粘膜に分布するERK神経の解析

    城戸瑞穂、張旌旗、山座孝義、田中輝男

    第47回歯科基礎医学会  2005.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Expression of iNOS and Nitrotyrosin in the Peri-Implant Epithelium in Rats International conference

    S.Mino, T.Yamaza, MA.Kido and T.Tanaka.

    20th Asian Oral Implant Academy  2005.10 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCは、骨形成を促進する

    下平大治、檀上敦、山座孝義、城戸瑞穂、田中輝男

    日本解剖学会第61回九州支部学術集会  2005.10 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCは、ヒト骨髄由来間様系幹細胞の骨形成能を促進する

    檀上敦、山座孝義、城戸瑞穂、田中輝男

    第46回日本組織細胞化学会総会・学術集会  2005.10 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Phosphrylation of ERK in taste papilla neurons by oral capsaicin International conference

    Kido MA, Zhang JQ, Yamaza T, Tanaka T

    35th annual meeting of Society for neuroscience  2005.11 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Expression of the epsilon isozyme of protein kinase C and the transient receptor potential vanilloid 1 receptors in the rat tongue and oral mucosa. International conference

    Zhang JQ, Kido MA, Yamaza T, Tanaka T

    35th annual meeting of Society for neuroscience  2005.11 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • ラット顎関節における一次知覚神経におけるMAPキナーゼのリン酸化

    佐々木貴司、石橋正基、城戸瑞穂、山座孝義、角静香、田中輝男

    第14回日本柔道整復接骨医学会  2005.12 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCの骨形成促進効果には一酸化窒素(NO)が関与する

    金森圭祐、萩尾寿彦、檀上敦、 山座孝義、城戸瑞穂、角静香、田中輝男

    第14回日本柔道整復接骨医学会  2005.12 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Cystatin C accelerates the osteogenic differentiation of bone marrow mesenchymal stem cells and increases bone formation in vivo. International conference

    A.Danjo, T.Yamaza, D.Shimohira, M.A.Kido and T.Tanaka

    Internal symposium of development and regeneration in oral and maxillofacial region  2006.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Activation of peripheral nerves in oral mucosa by oral capsaicin in “Oral Cell and Molecular Biology and Biocompatibility Polytechnic International conference

    2006.6 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Romania  

  • PHOSPHORYLATION OF ERK IN TASTE PAPILLA BY ORAL CAPSAICIN International conference

    M. A. Kido, J.Q. Zhang, T. Yamaza, T. Tanaka

    2006.7 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Capsaicin receptor expression in the rat temporomandibular joint International conference

    Ioi H, Kido MA, Yamaza T, Nakata S, Nakasima A, Tanaka T

    2006.7 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 口腔粘膜におけるTRPV2発現解析

    城戸瑞穂、下平大治、檀上敦、張旌旗、山座孝義、田中輝男

    第48回歯科基礎医学会  2006.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCによる骨髄由来間葉系細胞におけるBMP2遺伝子発現の上昇を介した石灰化組織形成の促進

    檀上敦、山座孝義、下平大治、西嶋克司、城戸瑞穂、田中輝男

    第48回歯科基礎医学会  2006.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット歯肉におけるTRPV2発現の解析

    下平大治、城戸瑞穂、檀上敦、山座孝義、張旌旗、田中輝男

    第48回歯科基礎医学会  2006.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • The expression of TRPV2 in Osteoclast International conference

    Y. Tsuji, MA Kido, T. Yamaza, H. Ioi, K. Nakamura, A. Nakasima, T. Tanaka

    85th IADR General Session & Exhibition of IADR  2007.3 

     More details

    Event date: 2011.4

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ラット歯肉におけるTRPV2 発現の解析

    下平大治、城戸瑞穂、檀上敦、張旌旗、山座孝義、田中輝男

    第49回歯科基礎医学会学術大会  2007.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCのマウス骨髄間葉系細胞における骨形成促進効果

    檀上敦、山座孝義、下平大治、西嶋克司、城戸瑞穂、田中輝男

    第49回歯科基礎医学会学術大会  2007.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 口蓋ひだ上皮細胞におけるカプサイシン受容体TRPV1発現細胞の解析

    城戸瑞穂、王冰、張旌旗、檀上敦、下平大治、山座孝義、田中輝男

    第49回歯科基礎医学会学術大会  2007.8 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンCは骨髄由来間葉系幹細胞の骨への分化を促進する International conference

    檀上敦、山座孝義、城戸瑞穂、下平大治、田中輝男

    第5回再生歯科医学会  2007.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 骨芽細胞の分化におけるP13K/Akt経路の役割

    檀上敦,城戸瑞穂,山座孝義,下平大治,牧野友祐,渡邉敏之,山下佳雄

    第50回歯科基礎医学会学術大会  2008.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット歯肉におけるTRPV2発現の解析

    下平大治,檀上敦,村田直久,牧野友祐,張旌旗,山座孝義,城戸瑞穂

    第50回歯科基礎医学会学術大会  2008.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • ラット歯肉におけるTRPV2の発現

    下平大治、檀上敦,山座孝義,城戸瑞穂

    日本解剖学会第64回九州支部学術集会  2008.10 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • シスタチンC相互作用因子の解析

    牧野友祐, 檀上敦, 山座孝義, 笈田花子, 寺田善博, 城戸瑞穂

    第51回歯科基礎医学会  2009.9 

     More details

    Event date: 2011.4

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • マウス顎骨由来間葉系幹細胞の単離と特性解析

    山座孝義, 山座治義, 野中和明, 城戸瑞穂

    第51回歯科基礎医学会  2009.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • アレルギー状態は実験的歯の移動時における局所的な炎症性サイトカイン発現を増加する

    村田直久、五百井秀樹、山座孝義、高橋一郎、城戸瑞穂

    第51回歯科基礎医学会  2009.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 口腔上皮におけるカプサイシン感受性細胞の解析

    城戸瑞穂、王冰、鍛冶屋浩、岡部幸司、張旌旗、山座孝義

    第51回歯科基礎医学会  2009.9 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 骨修復過程におけるMBPの影響

    安河内雅之、馬場恭平、中島洋一、久遠龍史、米女博司、田中輝男、渡辺敏之、小野愛子、森田如一、芹澤篤、山座孝義、城戸瑞穂

    第19回日本柔道整復接骨医学会  2009.11 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 口腔粘膜上皮におけるTRPチャネルの発現と機能解析

    城戸瑞穂、王冰、鍛冶屋浩、岡部幸司、張旌旗、山座孝義

    第115回日本解剖学会学術集会総会  2010.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 全身性エリトマトーデスに対する乳歯歯髄幹細胞の再生医療学的応用

    山座孝義、山座治義、牧野友祐、城戸瑞穂、野中和明、久木田敏夫

    第52回歯科基礎医学会  2010.9 

     More details

    Event date: 2011.4

    Country:Japan  

  • Telomerase Activates Immunomodulatory Function of Bone Marrow Mesenchymal Stem Cells. International conference

    K. AKIYAMA, Y.-O. YOU, T. YAMAZA, C. CHEN, L. TANG, Y. JIN, X.-D. CHEN, S. GRONTHOS, and S. SHI.

    89th IADR General Session & Exhibition of IADR  2011.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • MSCT Restores Immune Homeostasis in Systemic Sclerosis Mice and Humans. International conference

    C. CHEN, K. AKIYAMA, T. YAMAZA, L. SUN, and S. SHI.

    89th IADR General Session & Exhibition of IADR  2011.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • TGF beta pathway in Mesenchymal Stem Cells from Ossifying Fibroma. International conference

    H. QIN, C. QU, T. YAMAZA, K. AKIYAMA, Q. ZHANG, A. LE, and S. SHI.

    89th IADR General Session & Exhibition of IADR  2011.3 

     More details

    Event date: 2011.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • 歯の幹細胞を用いた免疫細胞免疫細胞療法学的再生医療 Invited

    山座孝義

    第10回歯の発生生物学と再生に関するシンポジウム  2011.3 

     More details

    Event date: 2011.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:神奈川歯科大学附属横浜研修センター   Country:Japan  

  • 歯の幹細胞の基礎と応用 Invited

    山座孝義

    平成22年度「歯学連携ネットワークを活用した口腔からQOL向上を目指す研究」再生工学カテゴリー第2回研究集会  2010.12 

     More details

    Event date: 2010.12

    Presentation type:Oral presentation (invited, special)  

    Venue:広島   Country:Japan  

  • 実験的歯の移動時のアレルギー誘導性歯根吸収におけるロイコトリエンの関与

    村田直久、五百井秀樹、山座孝義、大内雅博、高橋一郎、城戸瑞穂

    第52回歯科基礎医学会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Immunotherapy with stem cells isolated from human baby teeth Invited International conference

    Takayoshi Yamaza

    The 21st Fukuoka International Symposium On Pediatiric/Maternal-Child Health Research  2010.7 

     More details

    Event date: 2010.7

    Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 骨髄間葉系幹細胞によるニッチ構築と生体制御 Invited

    山座孝義

    第115回日本解剖学会総会シンポジウム「顎顔面発生研究の新規展開:若手研究者の発想とねらい」  2010.3 

     More details

    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:盛岡   Country:Japan  

  • Immunomodulatory Properties of Stem Cells from Human Exfoliated Deciduous Teeth Invited International conference

    Takayoshi Yamaza

    The 5th International Symposium on "Dental and Craniofacial Morphogenesis and Tissue Regeneration; A View from Stem Cell Research"  2010.2 

     More details

    Event date: 2010.2

    Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • Mouse Mandible Contains Distinctive Mesenchymal Stem Cells Invited International conference

    Takayoshi Yamaza, Haruyoshi Yamaza, Guangwen Ren, Kentaro Akiyama,Chider Chen, Yufeng Shi, Kazuaki Nonaka, Songtao Shi1

    The 32th Annual Meeting of Society of Craniofacial Genetics, SCG Symposium Hot Tpoic in the Topics, New Breakthroughs in Craniofacial Genetics  2009.10 

     More details

    Event date: 2009.10

    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Stem Cell Property of Post-Migratory Cranial Neural Crest Cells and Their Utility in Alveolar Bone Regeneration and Tooth Development International conference

    Chung IH, Yamaza T, Zhao H, Choung PH, Shi S, Chai Y.

    International Conference on Frontiers of Oral and Craniofacial Research  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice. International conference

    Yamaza T, Miura Y, Akiyama K, Bi Y, Sonoyama W, Gronthos S, Chen W, Le A, Shi S.

    International Conference on Frontiers of Oral and Craniofacial Research  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • Mesenchymal stem cell transplantation reserves multi-organ dysfunction in systemic lupus erythematousus mice and human. International conference

    Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S.

    International Conference on Frontiers of Oral and Craniofacial Research  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • インプラント周囲上皮の封鎖機構について Invited

    山座孝義

    第100回 日本解剖学会 シンポジウム「歯と歯周組織の再生:最近の研究と応用を語る」  2003.4 

     More details

    Event date: 2003.4

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • E-64投与ラット破骨細胞におけるカテプシンL及び?型コラーゲンの局在に関する免疫細胞化学的研究

    諸井亮司,鮎川保則,山座孝義,田中輝男

    第13回日本骨代謝学会  1995.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • チタニウムコートインプラントを用いた骨-チタニウム界面の超微細構造

    鮎川保則,諸井亮司,山座孝義,田中輝男

    第13回日本骨代謝学会  1995.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • YM-175投与ラット破骨細胞におけるカテプシンLの局在およびトレーサーを用いた取り込み能に関する免疫細胞化学(細胞化学)的研究

    山座孝義,諸井亮司,鮎川保則,田中輝男

    第14回日本骨代謝学会  1996.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • ラット付着上皮内サブスタンスP及びカルシトニン遺伝子関連ペプチド含有神経について−共焦点レーザー顕微鏡と電子顕微鏡による観察−

    城戸瑞穂,山座孝義,坂井貴子,寺田善博,田中輝男

    第38回秋季日本歯周病学会学術大会  1996.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • ラット歯肉付着上皮における局所投与Horseradish peroxidase (HRP)の取り込みとカテプシンDによる細胞内消化に関する免疫細胞化学的研究

    山座孝義,城戸瑞穂,田中輝男

    第38回秋季日本歯周病学会学術大会  1996.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • マトリックスメタロプロテアーゼ阻害,KB-R7785は破骨細胞のmigrationを抑制する

    後藤哲哉,山座孝義,田中輝男

    第15回日本骨代謝学会  1997.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:大宮   Country:Japan  

  • 破骨細胞に対するサブスタンスPの作用とサブスタンスPレセプターの局在.

    後藤哲哉,城戸瑞穂,山座孝義,田中輝男

    第39回歯科基礎医学会学術大会  1997.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:北九州   Country:Japan  

  • ラット歯肉付着上皮細胞におけるシステインプロテアーゼの局在,および細胞内消化に関する研究−カテプシンB,H,およびトレーサーとして西洋わさびペルオキシターゼの局在に関する免疫細胞化学的研究−

    山座孝義,城戸瑞穂,田中輝男

    第39回秋季日本歯周病学会学術大会  1997.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ラット歯肉付着上皮細胞における局所投与サブスタンスPの影響に関する細胞化学的研究

    後藤康治,山座孝義,城戸瑞穂,赤峰昭文,田中輝男

    第39回秋季日本歯周病学会学術大会  1997.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ラット・インプラントー歯肉接合部における外来物質の透過性に関する研究

    池田英弘,山座孝義,田中輝男

    第41回春季日本歯周病学会学術大会  1998.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • Ultrastructual interface betweeen implant and peri-implant epithelium of rat. International conference

    H. Ikeda, T. Yamaza, Y. Ayukawa, M. Yoshinari, T. Inooue, M. Shimono, K. Koyano, and T. Tanaka.

    77th. International Assosiation of Dental Research  1999.4 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:Canada  

  • 試作根管シーラーの組織親和性に関する研究

    古川和洋,橋口勇,山座孝義,介田圭,中野嗣久,中牟田博敬,赤峰昭文.

    第110回日本歯科保存学会1999年度春季大会  1999.4 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福島   Country:Japan  

  • 破骨細胞におけるシステインプロテアーゼインヒビター,シスタチンCの局在.

    山座孝義,後藤哲哉,赤峰昭文,田中輝男

    第17回日本骨代謝学会  1999.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • マウス破歯細胞におけるカテプシンKの免疫電顕的局在について.

    辻康夫,山座孝義,田中輝男

    第41回歯科基礎医学会学術大会  1999.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • インプラント周囲上皮とその界面における閉鎖性に関する研究.

    池田英弘,山座孝義,吉成正雄,鮎川保則,古谷野潔,田中輝男

    第21回日本バイオマテリアル学会総会  1999.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Detection of cathepsin K mRNA and protein in mouse odontoclasts. International conference

    Y. Tsuji, T. Yamaza, S. Nakata, A. Nakashima, T. Goto, and T. Tanaka.

    78th. International Association for Dental Research  2000.4 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 顎関節モデルラットにおけるinterleukin-1 receptor(IL-1R)およびnuclear factor kB(NF-kB)の発現に関する組織細胞化学的研究

    深藏啓太郎,山座孝義,城戸瑞穂,田中輝男

    日本解剖学会第56回九州支部学術集会  2000.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 破骨細胞性骨吸収過程におけるPI3キナーゼの関与について

    西田浩史,山座孝義,山下英俊,橋口勇,小石裕子,小笠原貴子,吉嶺嘉人,中牟田博敬,赤峰昭文

    第113回日本歯科保存学会2000年度秋季大会  2000.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • ラット歯肉におけるサブスタンスPの多形核白血球に対する遊走作用について

    後藤康治,山座孝義,桑野計子,赤峰昭文

    第114回日本歯科保存学会2001年度春季大会  2001.4 

     More details

    Presentation type:Oral presentation (general)  

    Venue:横須賀   Country:Japan  

  • 歯根周囲組織における破骨細胞分化因子の局在に関する免疫組織化学的研究

    小笠原貴子,吉嶺嘉人,山座孝義,橋口勇,中野嗣久,赤峰昭文

    第114回日本歯科保存学会2001年度春季大会  2001.4 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:横須賀   Country:Japan  

  • Expression of osteocalcin in early matrix formation of reparative dentin after tooth cavity preparation. International conference

    M. Hirata, T. Yamaza, A. Akamine, and T. Tanaka.

    The International Conference on Dentin/Pulp Complex 2001  2001.5 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 顎関節炎モデルラットにおける反応性窒素酸化物の炎症増悪への関与

    深藏啓太郎,山座孝義,城戸瑞穂,築山能大,古谷野潔,田中輝男

    第14回日本顎関節学会総会・学術大会  2001.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • マウス歯牙移動時の破歯細胞におけるシスタチンCの局在に関する研究

    辻康夫,山座孝義,城戸瑞穂,中島昭彦,田中輝男

    第43回歯科基礎医学会学術大会  2001.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:さいたま市   Country:Japan  

  • ラット顎関節炎におけるカプサイシンレセプターの免疫組織化学的局在について

    村上理恵,城戸瑞穂,増田啓太郎,山座孝義,中島昭彦,田中輝男

    第15回日本顎関節学会総会・学術大会  2002.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • インプラント−歯肉界面におけるラミニン5の発現について

    山座孝義,熱田生,室谷春江,城戸瑞穂,田中輝男

    日本解剖学会第58回九州支部学術集会  2002.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • 破骨細胞におけるカテプシンKおよびシスタチンCの遺伝子ならびに動態解析

    山座孝義,辻康夫,熱田生,室谷春江,後藤哲哉,田中輝男

    第44回歯科基礎医学会学術大会  2002.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • インプラント体周囲口腔粘膜上皮の形成過程におけるラミニン5の発現動態

    熱田生,山座孝義,吉成正雄,白岩昌,室谷春江,城戸瑞穂,寺田善博,田中輝男

    第44回歯科基礎医学会学術大会  2002.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ラットの口蓋及び舌におけるカプサイシン受容体の発現について

    室谷春江,城戸瑞穂,山座孝義,熱田生,寺田善博,田中輝男

    第44回歯科基礎医学会学術大会  2002.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 歯の移動時における骨吸収機構に関する研究

    辻康夫,山座孝義,名方俊介,田中輝男,中島昭彦

    第61回日本矯正歯科学会  2002.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋  

  • 純チタンインプラントとビスフォスフォネート固定純チタンインプラントに於ける骨形成量の相違について

    梶原浩,後藤哲哉,山座孝義,伊山慎二,鮎川保則,吉成正雄,田中輝男

    第24回日本バイオマテリアル学会総会  2002.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Phosphatidylinositol-3 kinase plays a role in vesicl transport in the secretory pathway of cathepsin K and cystatin C in osteoclasts. International conference

    T. Yamaza, I. Atsuta, Y. Tsuji, T. Goto, T. Tanaka

    1st joint meeting of the international bone and mineral society and the Japanese society for bone and mineral research  2003.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • チタンプレート上における口腔粘膜上皮の動態について

    熱田生、山座孝義、城戸瑞穂、田中輝男

    第32回九大生体材料・力学研究会  2003.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • チタンプレート上における高脂血症治療薬simbastatinの骨形成に対する影響の検索

    井出貴治、後藤哲哉、城戸瑞穂、山座孝義、田中輝男

    第32回九大生体材料・力学研究会  2003.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 破骨細胞の膜輸送過程におけるPI3キナーゼの関与について

    山座孝義、熱田生、鍵谷忠慶、室谷春江、城戸瑞穂、後藤哲哉、田中輝男

    第45回歯科基礎医学会学術大会  2003.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:盛岡   Country:Japan  

  • ラットの口蓋及び舌におけるカプサイシン受容体の発現について

    室谷春江、城戸瑞穂、山座孝義、熱田生、寺田善博、田中輝男

    第45回歯科基礎医学会学術大会  2003.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:盛岡   Country:Japan  

  • ラット口腔へのカプサイシン投与によるERKの活性化

    城戸瑞穂、張旌旗、室谷春江、山座孝義、田中輝男

    第45回歯科基礎医学会学術大会,  2003.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:盛岡   Country:Japan  

  • 修復象牙質形成過程における一酸化窒素の関与

    梅 予鋒、山座孝義、平田昌子、赤峰昭文

    第119回日本歯科保存学会2003年度秋季大会  2003.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:岐阜   Country:Japan  

  • 破骨細胞による骨吸収過程におけるPI3キナーゼの関与について

    城戸淳子、繁田奈美子、山座孝義、熱田 生、角 静香、中村丹奈、城戸瑞穂、田中輝男

    第12回日本柔道整復接骨医学会総会  2003.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • スタチン系薬剤(高脂血症治療薬)の骨形成および骨吸収に対する効果の検索

    金田 宰、伊藤昌朗、井出貴治、山座孝義、角 静香、中村丹奈、田中輝男

    第12回日本柔道整復接骨医学会総会  2003.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • チタンプレートに対する口腔粘膜上皮細胞接着でのphosphatidylinositol 3 kinaseの役割について

    熱田 生、山座孝義、吉成正雄、後藤哲哉、寺田善博、田中輝男

    第25回日本バイオマテリアル学会大会  2003.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 胆道閉鎖症由来乳歯幹細胞の特性とその肝再生能力

    園田 聡一朗, 村田 早羅, 山座 孝義

    第19回日本再生医療学会総会  2020.9 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 胆道閉鎖症患児由来乳歯幹細胞の細胞移植治療効果低下をもたらす機構の解析

    園田 聡一朗, 村田 早羅, 加藤 大樹, 久本 由香里, 上原 範久, 久木田 敏夫, 山座 孝義

    第62回日本歯科基礎医学会総会  2020.9 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Extracellular vesicles-mediated novel therapeutic mechanism of deciduous toot pulp stem cell-based therapy for systemic lupus erythematosus. International conference

    Sonoda S, Yamaza T.

    The 69rd Annual Meeting of Japanese Association for Dental Research.  2021.10 

     More details

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 乳歯幹細胞の細胞外小胞を介した全身性エリテマトーデスの新規治療メカニズムの解明

    園田 聡一朗, 山座 孝義

    第63回日本歯科基礎医学会総会  2021.10 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 乳歯幹細胞の細胞外小胞による宿主間葉系幹細胞を標的とした全身性エリテマトーデス治療メカニズムの解明

    園田 聡一朗, 山座 孝義

    第21回日本再生医療学会総会  2022.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 骨転移性乳癌細胞由来細胞外小胞に内包されるmiR-92a-3pは成熟破骨細胞の生存を促進する(Bone metastatic mammary tumor cell-derived extracellular vesicles promote mature osteoclast longevity)

    上原 範久, 久本 由香里, 三上 剛和, 園田 聡一朗, 山座 孝義, 久木田 敏夫

    日本癌学会総会記事  2023.9  (一社)日本癌学会

     More details

    Language:English  

  • 胸腺間葉系ストロマ細胞による内在性制御性T細胞の産生メカニズムの解明

    園田 聡一朗, 久本 由香里, 加藤 大樹, 上原 範久, 山座 孝義

    Journal of Oral Biosciences Supplement  2023.9  (一社)歯科基礎医学会

     More details

    Language:Japanese  

  • 根尖歯乳頭組織由来幹細胞に発現する転写因子PITX2の機能解析

    久本 由香里, 園田 聡一朗, 加藤 大樹, 上原 範久, 山座 孝義

    Journal of Oral Biosciences Supplement  2023.9  (一社)歯科基礎医学会

     More details

    Language:Japanese  

  • 小児外科における最先端医療の現状と展望【International】ヒト脱落乳歯歯髄幹細胞移植によるhypoganglionosisに対する新規治療法開発

    吉丸 耕一朗, 園田 聡一朗, 山内 恵利佳, 河野 淳, 松浦 俊治, 山座 孝義, 小田 義直, 田尻 達郎, 田口 智章

    日本外科学会定期学術集会抄録集  2022.4  (一社)日本外科学会

     More details

    Language:Japanese  

  • ヒト乳歯歯髄幹細胞を用いた間質性膀胱炎に対する根治的治療法への挑戦

    岡部 彩美, Kareman Eljamal, 山座 孝義, 岡田 達憲, 牧 知子, 梶岡 俊一, 江藤 正俊

    日本排尿機能学会誌  2023.9  (一社)日本排尿機能学会

     More details

    Language:Japanese  

  • ヒト乳歯歯髄幹細胞を用いた間質性膀胱炎に対するの根治的治療法への挑戦

    梶岡 俊一, カレマン・エルジャマル , 山座 孝義, 岡部 彩美, 岡田 達憲, 牧 知子, 江藤 正俊

    国際医療福祉大学学会誌  2023.9  国際医療福祉大学学会

     More details

    Language:Japanese  

▼display all

MISC

  • A New Target of Dental Pulp-Derived Stem Cell-Based Therapy on Recipient Bone Marrow Niche in Systemic Lupus Erythematosus Reviewed

    Sonoda, S. & Yamaza, T.

    International journal of molecular sciences.   2022.4

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Is aspirin treatment an appropriate intervention for osteoporosis?

    Yamaza T, Akiyama K, Shi S.

    2008.12

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region.

    Miura M, Miura Y, Sonoyama W, Yamaza T, Gronthos S, Shi S.

    Oral Diseases   2006.11

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Cathepsins in the osteoclast.

    Goto T, Yamaza T, Tanaka T.

    551-558   2003.12

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Substance P and substance P receptors in bone and gingival tissues

    T. Goto, M. A. Kido, T. Yamaza, and T. Tanaka.

    Medical Electron Microscopy   2001.6

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【疾患と免疫の新たな関係】歯髄幹細胞を用いたSLEの治療戦略

    山座 孝義, 園田 聡一朗

    臨床免疫・アレルギー科   77 ( 5 )   575 - 583   2022.5   ISSN:1881-1930

     More details

    Language:Japanese   Publisher:(有)科学評論社  

  • 近未来の再生医療と外科 -肝再生医療の展望と乳歯歯髄幹細胞

    田口 智章 , 山座 孝義 , 松浦 俊治 , 高橋 良彰 , 岩中 剛 , 栁 佑典 , 吉丸 耕一郎 , 山座 冶義 , 野中 和明 , 中山 功一 , 小林 英司 , 大賀 正一

    臨床雑誌外科   2017.11

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 乳歯幹細胞を用いた肝再生研究

    柳佑典, 山座孝義, 山座治義, 野中和明, 中山功一, 吉丸耕一朗, 岩中剛, 高橋良彰, Rathi Yuniartha, 松浦俊治, 孝橋賢一, 小田義直, 大賀正一, 絵野沢伸, 小林英司, 田口智章

    小児外科   2017.11

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 希少消化器疾患に対する萌芽的研究の最前線】 ヒルシュスプルング病とその類縁疾患は再生医療で治せるか?

    吉丸 耕一朗, 山座 孝義, 栁 佑典, 江角 元史郎, 林田 真, 松浦 俊治, 中島 淳, 田口 智章

    分子消化器病   2015.3

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Immunocytochemical Localization of Substance P Neurokinin 1 Receptors in the Rat Temporomandibular Joint.

    Kido MA, Zhang JQ, Yamaza T, Tanaka T.

    Dentistry in Japan   2004.3

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Biological characteristics of the junctional epithelium.

    Shimono M, Ishikawa T, Enokiya Y, Muramatsu T, Matsuzaka K, Inoue T, Abiko Y, Yamaza T, Kido MA, Tanaka T, Hashimoto S.

    J Electron Microsc.   2003.12

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Expression of osteocalcin in early matrix formation of reparative dentin after tooth cavity preparation.

    M. Hirata, T.Yamaza, A. Akamine, T. Tanaka.

    Proceedings of the international conference on Dentin/Pulp Complex 2001   2002.3

     More details

    Language:English   Publishing type:Internal/External technical report, pre-print, etc.  

  • Histological examination of the biocompatibility of calcipex, a new calcium hydroxide-containing intracanal dressing, after filling bony defects.

    I. Hashiguchi, T. Yamaza, T. Nakano, Y. Yoshimine, H. Nakamuta, and A. Akamine.

    Dentistry in Japan   2001.3

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Industrial property rights

Patent   Number of applications: 3   Number of registrations: 9
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本歯科保存学会

  • 日本顎関節学会

  • 日本歯周病学会

  • 日本骨代謝学会

  • 歯科基礎医学会

  • 日本解剖学会

  • International association of Dental research

  • Japanese Association of Denal Research

  • 歯科基礎医学会

      More details

  • 日本骨代謝学会

      More details

  • 日本顎関節学会

      More details

  • 日本解剖学会

      More details

  • 日本歯科保存学会

      More details

  • 日本歯周病学会

      More details

▼display all

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2021

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2020

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • シンポジスト

    第18回日本再生学会総会 SY10消化管の再生医療  ( 神戸 ) 2019.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • Screening of academic papers

    Role(s): Peer review

    2019

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • シンポジスト

    アップデートシンポジウム10「骨改造の新局面:骨吸収から骨形成・骨再生への橋渡し機構を考える」 第60回日本歯科基礎医学会総会  ( 福岡 ) 2018.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • 準備委員

    第60回 日本歯科基礎医学会  ( 福岡 ) 2018.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:800

  • Screening of academic papers

    Role(s): Peer review

    2018

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:17

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • シンポジスト

    第122回日本解剖学会総会 日本解剖学会ワークショップ WS3肉眼解剖学における実習手順の実際  ( 長崎 ) 2017.3 - 2017.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • Screening of academic papers

    Role(s): Peer review

    2017

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 座長

    ( 福岡 ) 2016.2

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 座長(Chairmanship)

    頭脳循環を加速する戦略的国際研究ネットワーク推進プログラムシンポジウム  ( 福岡 ) 2016.2

     More details

    Type:Competition, symposium, etc. 

  • 座長

    サテライトシンポジウム7 「SS7「歯髄間葉系幹細胞の最先端研究」」 第57回歯科基礎医学会  ( 新潟 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • オーガナイザー

    サテライトシンポジウム7 「SS7「歯髄間葉系幹細胞の最先端研究」」 第57回歯科基礎医学会  ( 新潟 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    サテライトシンポジウム7 「SS7「歯髄間葉系幹細胞の最先端研究」」 第57回歯科基礎医学会  ( 新潟 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    サテライトシンポジウム7 「SS7「歯髄間葉系幹細胞の最先端研究」」 第57回歯科基礎医学会  ( 新潟 ) 2015.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    ( 福岡 ) 2015.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 座長(Chairmanship)

    頭脳循環を加速する戦略的国際研究ネットワーク推進プログラムKich Off Symposium  ( 福岡 ) 2015.2

     More details

    Type:Competition, symposium, etc. 

  • 座長

    ( 福岡 ) 2015.2

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 座長(Chairmanship)

    第56回歯科基礎医学会サテライトシンポジウム7 「間葉系幹細胞の直接的・間接的な組織再生への関与を考える」  ( 福岡 ) 2014.9

     More details

    Type:Competition, symposium, etc. 

  • オーガナイザー

    サテライトシンポジウム7 「間葉系幹細胞の直接的・間接的な組織再生への関与を考える」 第56回歯科基礎医学会  ( 福岡 ) 2014.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    サテライトシンポジウム7 「間葉系幹細胞の直接的・間接的な組織再生への関与を考える」 第56回歯科基礎医学会  ( 福岡 ) 2014.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    シンポジウム 1 「口腔組織に由来する幹細胞の医科への応用」第68回日本口腔科学学会  ( 東京 ) 2014.5

     More details

    Type:Competition, symposium, etc. 

    Number of participants:1,000

  • 演者

    共進化社会システム創成拠点フォーラム  ( 東京 ) 2014.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジスト

    SY-8 口腔領域細胞を応用した再生医療 第13回日本再生医療学会  ( 京都 ) 2014.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • シンポジスト

    ( 福岡 ) 2014.2 - 2014.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 座長

    ( 福岡 ) 2014.2 - 2014.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 座長(Chairmanship)

    第55回歯科基礎医学会サテライトシンポジウム5 「口腔組織幹細胞の未来志向」〜歯髄細胞は臨床応用可能か?  ( 岡山 ) 2013.9

     More details

    Type:Competition, symposium, etc. 

  • オーガナイザー

    サテライトシンポジウム5 「口腔組織幹細胞の未来志向」ーヒト歯髄細胞は臨床応用可能か?  第55回歯科基礎医学会  ( 岡山 ) 2013.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • シンポジスト

    サテライトシンポジウム5 「口腔組織幹細胞の未来志向」ーヒト歯髄細胞は臨床応用可能か?  第55回歯科基礎医学会  ( 岡山 ) 2013.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • シンポジスト

    シンポジウム8 歯髄幹細胞 第34回日本炎症・再生医学会  ( 京都 ) 2013.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • オーガナイザー

    サテライトシンポジウム1 歯髄組織のパラダイムシフト 第54回歯科基礎医学会  ( 郡山 ) 2012.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • シンポジスト

    サテライトシンポジウム1 歯髄組織のパラダイムシフト 第54回歯科基礎医学会  ( 郡山 ) 2012.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 座長(Chairmanship)

    第54回歯科基礎医学会(サテライトシンポジウム1 歯髄組織のパラダイムシフト)  ( 郡山 ) 2012.9

     More details

    Type:Competition, symposium, etc. 

  • シンポジスト

    サテライトシンポジウム3 歯の幹細胞 第53回歯科基礎医学会  ( 岐阜 ) 2011.9 - 2011.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • 招待講師

    大阪歯科大学 エンジョイミーティングの会  ( 大阪歯科大学 天満橋学舍 ) 2011.6

     More details

    Type:Competition, symposium, etc. 

    Number of participants:20

  • シンポジスト

    日本顕微鏡学会第67回学術講演会 シンポジウム 歯科インプラントの顕微鏡解析  ( 福岡 ) 2011.5

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • シンポジスト

    第10回歯の発生生物学と再生に関するシンポジウム  ( 神奈川歯科大学附属横浜研修センター ) 2011.3

     More details

    Type:Competition, symposium, etc. 

  • 招待講演(特別講演)

    平成22年度「歯学連携ネットワークを活用した口腔からQOL向上を目指す研究」再生工学カテゴリー第2回研究集会  ( 広島大学歯学部 ) 2010.12

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • Invited Speaker International contribution

    The 21st Fukuoka International Symposium On Pediatiric/Maternal-Child Health Research  ( Fukuoka Japan ) 2010.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:50

  • シンポジスト

    第115回日本解剖学会総会シンポジウム「顎顔面発生研究の新規展開:若手研究者の発想とねらい」  ( 盛岡 ) 2010.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • シンポジスト International contribution

    2010.2

     More details

    Type:Competition, symposium, etc. 

    Number of participants:100

  • シンポジスト International contribution

    2009.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:100

  • シンポジスト

    第100回 日本解剖学会 シンポジウム「歯と歯周組織の再生:最近の研究と応用を語る」  ( 福岡 ) 2003.4

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • 準備委員

    第102回 日本歯科保存学会  ( 福岡 ) 2002.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:800

▼display all

Research Projects

  • 胸腺髄質線維芽細胞による制御性T細胞の生成制御因子の探究

    Grant number:24K12873  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    園田 聡一朗, 山座 孝義

      More details

    Grant type:Scientific research funding

    制御性T細胞(Treg)は「免疫寛容」を実装した司令塔である。胸腺で生成される内在性Treg(nTreg)には自己抗体産生の制御に関わるサブセットが報告されており、nTregが自己免疫疾患の発症に重要な働きをもつことが示唆されている。しかし、nTregの生成メカニズムについては不明な点が多く残されている。髄質線維芽細胞(mFB)が間葉系ストロマ細胞として同定され、mFBがnTregの生成に関わる微小環境を形成する細胞として注目されている。本研究では、mFBによるnTreg生成の分子メカニズムの解明を試み、mFBを標的とした自己免疫疾患の新たな治療法の開発に向けた学術的基盤の構築を目指す。

    CiNii Research

  • 口腔がんの間質をターゲットとした新規治療法の開発研究

    Grant number:24K13159  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    合島 怜央奈, 山座 孝義, 山下 佳雄, 檀上 敦

      More details

    Grant type:Scientific research funding

    口腔がん治療において、十分な安全域での手術を実施した場合でも、局所再発や転移に難渋する高悪性度のがんが存在する。また、切除不能症例は予後の改善に至っておらず、口腔がんの生存率向上には、高悪性度の再発・転移症例や切除不能例に対する新規治療法の開発が急務である。口腔がんではがん実質のみならず、がん間質を構成するがん特異的な微小環境が極めて重要な役割を担う。本申請課題では、がん間質の性状を変化させるメカニズムを明らかにし、正常化したがん間質が実質に与える影響について明らかにする。

    CiNii Research

  • 口腔がんの転移をもたらすリンパ節線維芽細胞様細網細胞の変異メカニズムの解明

    Grant number:23K27762  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(B)

    山座 孝義, 園田 聡一朗, 久本 由香里

      More details

    Grant type:Scientific research funding

    口腔がんのリンパ節転移は不顕性に進行し、転移後に発見されるケースが多い。患者のQOL向上のために、低侵襲的な口腔がんのリンパ節転移に対する新規治療法が必要である。センチネルリンパ節は、がん遠隔転移の防波堤である。がん転移センチネルリンパ節では、線維芽細胞様細網細胞による物質輸送系の線維化が起こり、T細胞による抗腫瘍免疫機能が低下すると考えられている。本研究では、口腔がん細胞が線維芽細胞様細網細胞を介して抗腫瘍免疫機能を抑制するメカニズムおよびセンチネルリンパ節への転移機序を解明し、センチネルリンパ節転移に対する非外科的治療法の学術的基盤の確立を目指す。

    CiNii Research

  • 乳歯歯髄幹細胞によるヒルシュスプルング病と類縁疾患の病因解明および根治療法の開発

    Grant number:23K21447  2024.4 - 2026.3

    科学研究費助成事業  基盤研究(B)

    田口 智章, 田尻 達郎, 松浦 俊治, 梶岡 俊一, 山座 孝義, 山座 治義, 孝橋 賢一, 樗木 晶子, 吉丸 耕一朗

      More details

    Grant type:Scientific research funding

    継続課題のため、記入しない。

    CiNii Research

  • 乳歯歯髄幹細胞によるヒルシュスプルング病と類縁疾患の病因解明および根治療法の開発

    Grant number:21H02993  2021.4 - 2026.3

    科学研究費助成事業  基盤研究(B)

    田口 智章, 田尻 達郎, 松尾 忠行, 松浦 俊治, 梶岡 俊一, 山座 孝義, 山座 治義, 孝橋 賢一, 樗木 晶子, 中園 栄里, 河野 淳, 吉丸 耕一朗, 桐野 浩輔

      More details

    Grant type:Scientific research funding

    厚生労働省指定難病である広範囲型ヒルシュスプルング病(広範囲H病)やヒルシュスプルング病類縁疾患(H類縁)に属する腸管神経節細胞僅少症(Hypo)、慢性特発性偽性腸閉塞症(CIIP)、巨大膀胱短小結腸腸管蠕動不全症(MMIHS)は、小児期に発症し、著明な腹部膨満を呈す難治性腸管蠕動不全症である。
    本研究はH病およびHypo, CIIP, MMIHSに対する患児由来SHEDを用いた自家細胞移植による早期臨床応用を目指す。
    本研究成果を基盤とし、移植した自家SHEDが生体内で機能的腸管神経系細胞として生着すれば、腸管蠕動不全および患児のQOL/生命予後が劇的に改善することが見込まれる。

    CiNii Research

  • Development of a novel treatment for oral cancer using secretory products and cells associated with mesenchymal stem cells

    Grant number:21K10046  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • 口腔から健康長寿を支えるプロジェクト推進に向けた研究拠点構築プログラム

    2014 - 2017

    日本学術振興会  頭脳循環を加速する戦略的国際研究ネットワーク推進プログラム

      More details

    Authorship:Coinvestigator(s)  Grant type:Joint research

  • ヒト乳歯幹細胞を用いた造血機能再生医療へのチャレンジ

    Grant number:24659815  2012 - 2014

    科学研究費助成事業  挑戦的萌芽研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 骨形成におけるシスタチンCと結合タンパクの相互作用と機能解析

    Grant number:21592333  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 口腔上皮由来幹細胞による粘膜再生は線維芽細胞増殖因子により加速する

    Grant number:21592482  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Scientific research funding

  • シスタチンCの結合タンパクの検索と骨形成における機能解析

    Grant number:19592117  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 破骨細胞性骨吸収過程の小胞輸送におけるPI3-キナーゼの機能解析

    Grant number:17591917  2005 - 2006

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • ストレスが歯周病に及ぼす影響における神経ペプチドの関与の解析

    Grant number:00170473  2004 - 2005

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 高脂血症治療薬シンバスタチンは骨形成を促進し、骨吸収を抑制するか

    Grant number:60077667  2004 - 2005

    科学研究費助成事業  萌芽研究

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 破骨細胞におけるシスタチンCの新たな機能(蛋白分解酵素活性抑制以外)はあるか?

    Grant number:15659437  2003 - 2004

    科学研究費助成事業  萌芽研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 唐辛子カプサイシンの口腔感覚受容機構の解明

    Grant number:60253457  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 上皮幹細胞を用いた自家培養口腔粘膜の短期間で高能率な作製法の開発

    Grant number:60077667  2002 - 2003

    科学研究費助成事業  萌芽研究

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ストレスが付着上皮における歯周病の発症および進行に及ぼす影響の解析

    Grant number:00170473  2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • チタン-口腔上皮界面でのヘミデスモゾーム/基底膜の構成タンパクの発現と産生

    Grant number:60077667  2001 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 顎関節炎発症メカニズムの解明

    Grant number:00136508  2001 - 2002

    科学研究費助成事業  萌芽研究

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 災症性骨吸収における破骨細胞でのシグナル伝達経路の解明とその分化・機能変化の解析

    Grant number:80304814  2001 - 2002

    科学研究費助成事業  若手研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 象牙芽細胞の分化における一酸化窒素の機能に関する分子生物学的解析

    Grant number:00117053  2000 - 2001

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 修復象牙質形成における転写因子(AP-1)の発現とその機能の解析

    Grant number:12671855  2000 - 2001

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 破骨細胞性骨吸収における小胞輸送関連シグナル伝達分子の発現の解析

    Grant number:11771185  1999 - 2000

    日本学術振興会  科学研究費助成事業  奨励研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 付着上皮細胞における一酸化窒素合成酵素発現の解析

    Grant number:11672085  1999 - 2000

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 新生象牙芽細胞の分化過程における基質蛋白発現パタ-ン解析

    Grant number:09671958  1997 - 1998

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

▼display all

Educational Activities

  • 1. Lecture and Practice of Human Anatomy to undergraduate dental students
    2. Lecture and Practice of Human Oral Anatomy to undergraduate dental students
    3. Lecture and Practice of Human Tooth Anatomy to undergraduate dental students
    4. Lecture of Human Development to undergraduate dental students
    5. Lecture and Practice of Human Oral Histology to undergraduate dental students
    6. Early exposure to undergraduate dental students
    7. Research exposure to undergraduate dental students
    8. Scientific instruction to graduate students
    9. Scientific instruction to undergraduate students

Class subject

  • 解剖学実習2

    2024.12 - 2025.2   Winter quarter

  • 口腔組織学3

    2024.12 - 2025.2   Winter quarter

  • 口腔解剖学4

    2024.12 - 2025.2   Winter quarter

  • 解剖学実習1

    2024.10 - 2024.12   Fall quarter

  • 口腔組織学2

    2024.10 - 2024.12   Fall quarter

  • 口腔解剖学3

    2024.10 - 2024.12   Fall quarter

  • 口腔組織学1

    2024.6 - 2024.8   Summer quarter

  • 口腔解剖学2

    2024.6 - 2024.8   Summer quarter

  • 解剖学2

    2024.6 - 2024.8   Summer quarter

  • 発生学

    2024.4 - 2024.6   Spring quarter

  • 口腔解剖学1

    2024.4 - 2024.6   Spring quarter

  • 解剖学1

    2024.4 - 2024.6   Spring quarter

  • 解剖学実習2

    2023.12 - 2024.2   Winter quarter

  • 口腔組織学3

    2023.12 - 2024.2   Winter quarter

  • 口腔解剖学4

    2023.12 - 2024.2   Winter quarter

  • 解剖学実習1

    2023.10 - 2023.12   Fall quarter

  • 口腔組織学2

    2023.10 - 2023.12   Fall quarter

  • 口腔解剖学3

    2023.10 - 2023.12   Fall quarter

  • 口腔組織学1

    2023.6 - 2023.8   Summer quarter

  • 口腔解剖学2

    2023.6 - 2023.8   Summer quarter

  • 解剖学2

    2023.6 - 2023.8   Summer quarter

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology and Oral Anatomy

    2023.4 - 2024.3   Full year

  • Oral Biological Science

    2023.4 - 2024.3   Full year

  • 解剖学

    2023.4 - 2024.3   Full year

  • Oral Biological Science

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2023.4 - 2024.3   Full year

  • 発生学

    2023.4 - 2023.6   Spring quarter

  • 口腔解剖学1

    2023.4 - 2023.6   Spring quarter

  • 解剖学1

    2023.4 - 2023.6   Spring quarter

  • 解剖学実習2

    2022.12 - 2023.2   Winter quarter

  • Molecular Cell Biology and Oral Anatomy (Core) D

    2022.12 - 2023.2   Winter quarter

  • 口腔組織学3

    2022.12 - 2023.2   Winter quarter

  • 口腔解剖学4

    2022.12 - 2023.2   Winter quarter

  • 解剖学実習1

    2022.10 - 2022.12   Fall quarter

  • Molecular Cell Biology and Oral Anatomy (Core) C

    2022.10 - 2022.12   Fall quarter

  • 口腔組織学2

    2022.10 - 2022.12   Fall quarter

  • 口腔解剖学3

    2022.10 - 2022.12   Fall quarter

  • 口腔組織学1

    2022.6 - 2022.8   Summer quarter

  • 口腔解剖学2

    2022.6 - 2022.8   Summer quarter

  • 解剖学2

    2022.6 - 2022.8   Summer quarter

  • Molecular Cell Biology & Oral Anatomy

    2022.4 - 2023.3   Full year

  • 解剖学

    2022.4 - 2023.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2022.4 - 2023.3   Full year

  • Oral Biological Science

    2022.4 - 2023.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2022.4 - 2023.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2022.4 - 2023.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2022.4 - 2023.3   Full year

  • 発生学

    2022.4 - 2022.6   Spring quarter

  • 発生学

    2022.4 - 2022.6   Spring quarter

  • 口腔解剖学1

    2022.4 - 2022.6   Spring quarter

  • 解剖学1

    2022.4 - 2022.6   Spring quarter

  • 解剖実習

    2021.10 - 2022.3   Second semester

  • 口腔組織学2

    2021.10 - 2022.3   Second semester

  • 解剖学

    2021.4 - 2022.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2021.4 - 2022.3   Full year

  • Molecular Cell Biology & Oral Anatomy

    2021.4 - 2022.3   Full year

  • Oral Biological Science

    2021.4 - 2022.3   Full year

  • 硬組織研究法

    2021.4 - 2022.3   Full year

  • 口腔解剖学

    2021.4 - 2022.3   Full year

  • 歯牙解剖学実習

    2021.4 - 2021.9   First semester

  • 発生学

    2021.4 - 2021.9   First semester

  • 解剖実習

    2020.10 - 2021.3   Second semester

  • 口腔組織学2

    2020.10 - 2021.3   Second semester

  • 解剖学

    2020.4 - 2021.3   Full year

  • 分子口腔解剖学演習

    2020.4 - 2021.3   Full year

  • 分子口腔解剖学

    2020.4 - 2021.3   Full year

  • 硬組織研究法

    2020.4 - 2021.3   Full year

  • リサーチエクスポージャーII

    2020.4 - 2021.3   Full year

  • 口腔解剖学

    2020.4 - 2021.3   Full year

  • 歯牙解剖学実習

    2020.4 - 2020.9   First semester

  • アーリーエクスポージャーII

    2020.4 - 2020.9   First semester

  • 口腔組織学1

    2020.4 - 2020.9   First semester

  • 発生学

    2020.4 - 2020.9   First semester

  • 解剖実習

    2019.10 - 2020.3   Second semester

  • 発生学

    2019.10 - 2020.3   Second semester

  • 解剖学

    2019.4 - 2020.3   Full year

  • 分子口腔解剖学演習

    2019.4 - 2020.3   Full year

  • リサーチエクスポージャーII

    2019.4 - 2020.3   Full year

  • 分子口腔解剖学

    2019.4 - 2020.3   Full year

  • 硬組織研究法

    2019.4 - 2020.3   Full year

  • 口腔解剖学

    2019.4 - 2020.3   Full year

  • 歯牙解剖学実習

    2019.4 - 2019.9   First semester

  • 口腔組織学2

    2019.4 - 2019.9   First semester

  • アーリーエクスポージャーII

    2019.4 - 2019.9   First semester

  • 解剖実習

    2018.10 - 2019.3   Second semester

  • 発生学

    2018.10 - 2019.3   Second semester

  • 解剖学

    2018.4 - 2019.3   Full year

  • 分子口腔解剖学演習

    2018.4 - 2019.3   Full year

  • リサーチエクスポージャーII

    2018.4 - 2019.3   Full year

  • 分子口腔解剖学

    2018.4 - 2019.3   Full year

  • 硬組織研究法

    2018.4 - 2019.3   Full year

  • 口腔解剖学

    2018.4 - 2019.3   Full year

  • 歯牙解剖学実習

    2018.4 - 2018.9   First semester

  • アーリーエクスポージャーII

    2018.4 - 2018.9   First semester

  • 解剖実習

    2017.10 - 2018.3   Second semester

  • リサーチエクスポージャーII

    2017.10 - 2018.3   Second semester

  • 発生学

    2017.10 - 2018.3   Second semester

  • 解剖学

    2017.4 - 2018.3   Full year

  • 分子口腔解剖学演習

    2017.4 - 2018.3   Full year

  • 分子口腔解剖学

    2017.4 - 2018.3   Full year

  • 硬組織研究法

    2017.4 - 2018.3   Full year

  • 口腔解剖学

    2017.4 - 2018.3   Full year

  • アーリーエクスポージャーII

    2017.4 - 2017.9   First semester

  • 歯牙解剖学実習

    2017.4 - 2017.9   First semester

  • 発生学

    2016.10 - 2017.3   Second semester

  • 解剖実習

    2016.10 - 2017.3   Second semester

  • 分子口腔解剖学演習

    2016.4 - 2017.3   Full year

  • 分子口腔解剖学

    2016.4 - 2017.3   Full year

  • 硬組織研究法

    2016.4 - 2017.3   Full year

  • 口腔解剖学

    2016.4 - 2017.3   Full year

  • 解剖学

    2016.4 - 2017.3   Full year

  • アーリーエクスポージャーII

    2016.4 - 2016.9   First semester

  • 歯牙解剖学実習

    2016.4 - 2016.9   First semester

  • 発生学

    2015.10 - 2016.3   Second semester

  • 解剖実習

    2015.10 - 2016.3   Second semester

  • 解剖学

    2015.4 - 2016.3   Full year

  • 分子口腔解剖学演習

    2015.4 - 2016.3   Full year

  • 分子口腔解剖学

    2015.4 - 2016.3   Full year

  • 硬組織研究法

    2015.4 - 2016.3   Full year

  • 口腔解剖学

    2015.4 - 2016.3   Full year

  • アーリーエクスポージャーII

    2015.4 - 2015.9   First semester

  • 歯牙解剖学実習

    2015.4 - 2015.9   First semester

  • 解剖実習

    2014.10 - 2015.3   Second semester

  • 分子口腔解剖学演習

    2014.4 - 2015.3   Full year

  • 分子口腔解剖学

    2014.4 - 2015.3   Full year

  • 硬組織研究法

    2014.4 - 2015.3   Full year

  • 口腔解剖学

    2014.4 - 2015.3   Full year

  • 解剖学

    2014.4 - 2015.3   Full year

  • 口腔細胞生物学

    2014.4 - 2014.9   First semester

  • 歯牙解剖学実習

    2014.4 - 2014.9   First semester

  • 解剖実習

    2013.10 - 2014.3   Second semester

  • 解剖学

    2013.4 - 2014.3   Full year

  • 口腔解剖学

    2013.4 - 2014.3   Full year

  • 硬組織研究法

    2013.4 - 2014.3   Full year

  • 分子口腔解剖学演習

    2013.4 - 2014.3   Full year

  • 分子口腔解剖学

    2013.4 - 2014.3   Full year

  • 歯牙解剖学実習

    2013.4 - 2013.9   First semester

  • 口腔細胞生物学

    2013.4 - 2013.9   First semester

  • 解剖実習

    2012.10 - 2013.3   Second semester

  • 総合歯科学

    2012.10 - 2013.3   Second semester

  • 解剖学

    2012.4 - 2013.3   Full year

  • 分子口腔解剖学演習

    2012.4 - 2013.3   Full year

  • 分子口腔解剖学

    2012.4 - 2013.3   Full year

  • 硬組織研究法

    2012.4 - 2013.3   Full year

  • 口腔細胞生物学

    2012.4 - 2012.9   First semester

  • アーリーエクスポージャーII

    2012.4 - 2012.9   First semester

  • 解剖実習

    2011.10 - 2012.3   Second semester

  • 解剖学

    2011.4 - 2012.3   Full year

  • 分子口腔解剖学演習

    2011.4 - 2012.3   Full year

  • 分子口腔解剖学

    2011.4 - 2012.3   Full year

  • 硬組織研究法

    2011.4 - 2012.3   Full year

  • 口腔細胞生物学

    2011.4 - 2011.9   First semester

  • 解剖実習

    2010.10 - 2011.3   Second semester

  • Oral Bilogical Science (G30 program)

    2010.10 - 2011.3   Second semester

  • 解剖学

    2010.4 - 2011.3   Full year

  • 分子口腔解剖学演習

    2010.4 - 2011.3   Full year

  • 分子口腔解剖学

    2010.4 - 2011.3   Full year

  • 硬組織研究法

    2010.4 - 2011.3   Full year

  • アーリーエクスポージャーII

    2010.4 - 2010.9   First semester

  • 解剖実習

    2009.10 - 2010.3   Second semester

  • 硬組織研究法

    2009.4 - 2010.3   Full year

  • 解剖実習

    2004.10 - 2005.3   Second semester

  • 硬組織研究法

    2004.4 - 2005.3   Full year

▼display all

FD Participation

  • 2017.11   Role:Participation   Title:ARO次世代医療センターの活用方法

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role:Participation   Title:CBT作問者のための説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role:Participation   Title:CBT作問ワークショップ

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.9   Role:Participation   Title:科研費獲得のポイント! 科学研究費補助金制度と研究計画調書作成時の注意点

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.8   Role:Participation   Title:新GPA制度実施のためのFDについて

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.3   Role:Participation   Title:TBLとはどのような教育手法か

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.9   Role:Participation   Title:PBLチュートリアルチューター講習会(第2回)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:昭和大学におけるPBL-チュートリアルの取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:歯学教育を取り巻く環境変化と求められる対応 =歯学教育の改善・充 実に関する調査研究協力者会議を中心に=

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:歯科保健医療対策の動向

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.3   Role:Participation   Title:歯学研究院次期中期目標・計画について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.1   Role:Participation   Title:化学物質の安全管理対策

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.5   Role:Participation   Title:マップクエスト

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.4   Role:Participation   Title:CBT問題作成説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Participation in international educational events, etc.

  • 2012.9

    九州大学 G30プロジェクトオフィス

    「英語による教授能力」向上のためのワークショップ

      More details

    Venue:日本、福岡市

    Number of participants:22

  • 2009.8

    九州大学歯学部、JICA

    平成21年度JICA口腔健康科学研究研修コースアクションプラン発表会(平成21年8月6日)

      More details

    Venue:日本、福岡市

    Number of participants:20

  • 2009.5

    岡山大学大学院医歯薬学総合研究科、岡山大学歯学部

    第2回岡山医療教育国際シンポジウム

      More details

    Venue:日本、岡山市

    Number of participants:200

Other educational activity and Special note

  • 2010  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • パラメディカル各種専門学校生(福岡県立消防学校、福岡県立視覚特別支援学校、福岡市医師会立 看護専門学校 第一看護学科・看護高等課程、福岡県歯科医師会立 福岡歯科衛生専門学校 歯科衛生士科、九州医療専門学校 歯科衛生士科・歯科技工士科、博多メディカル専門学校 歯科衛生士科、福岡医健専門学校 歯科衛生士科)に対する解剖学講義ならびに解剖学実習

Social Activities

  • 「口の中の秘宝」という題目での講演

    (株)愛歯・(株)セルテクノロジー  鹿児島  2017.10

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 「口の中の秘宝」という題目での講演

    (株)愛歯・(株)セルテクノロジー  福岡  2017.7

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 「口の中の秘宝」という題目での講演

    (株)愛歯・(株)セルテクノロジー  熊本  2017.3

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

Media Coverage

  • 乳歯幹細胞に関する研究を紹介(3) Newspaper, magazine

    2020.4

     More details

    乳歯幹細胞に関する研究を紹介(3)

  • 乳歯幹細胞に関する研究を紹介(2) Newspaper, magazine

    2020.2

     More details

    乳歯幹細胞に関する研究を紹介(2)

  • 乳歯幹細胞に関する研究を紹介(1) Newspaper, magazine

    2019.12

     More details

    乳歯幹細胞に関する研究を紹介(1)

  • 乳歯幹細胞を用いた肝細胞再生研究の紹介 TV or radio program

    テレビ東京 『ミライダネ』 〜捨てていた歯で治療!? 驚きの可能性  2017.10

     More details

    乳歯幹細胞を用いた肝細胞再生研究の紹介

  • 特集(希少消化器疾患に対する萌芽的研究の最前線)におけつ我々の研究の試みを紹介 Newspaper, magazine

    分子消化器病  2015.3

     More details

    特集(希少消化器疾患に対する萌芽的研究の最前線)におけつ我々の研究の試みを紹介

  • 乳歯幹細胞を用いた肝細胞再生研究の紹介 TV or radio program

    BS-TBS 特別番組『抜けた歯は捨てるな! 再生医療革命 ~歯に隠された秘密~』  2015.3

     More details

    乳歯幹細胞を用いた肝細胞再生研究の紹介

  • 読売新聞(1月8日付朝刊)に「乳歯幹細胞で肝臓治療」と題して研究が紹介された。 山座孝義講師(歯学研究院・分子口腔解剖学)と田口智章教授(医学研究院・小児外科学)らの研究グループは、抜けた乳歯から様々な細胞に分化する幹細胞 を取り出し、先天性の肝臓疾患の治療などに応用する研究を本格化させる。2014 年度にミニブタを使い、乳歯幹細胞から作製した肝臓細胞を移植する試験を始める。研究グループは「捨てられる乳歯なので倫理面の問題がなく安全性も高い。将来的に人への治療につなげたい」としている。 Newspaper, magazine

    読売新聞  2014.1

     More details

    読売新聞(1月8日付朝刊)に「乳歯幹細胞で肝臓治療」と題して研究が紹介された。

    山座孝義講師(歯学研究院・分子口腔解剖学)と田口智章教授(医学研究院・小児外科学)らの研究グループは、抜けた乳歯から様々な細胞に分化する幹細胞 を取り出し、先天性の肝臓疾患の治療などに応用する研究を本格化させる。2014 年度にミニブタを使い、乳歯幹細胞から作製した肝臓細胞を移植する試験を始める。研究グループは「捨てられる乳歯なので倫理面の問題がなく安全性も高い。将来的に人への治療につなげたい」としている。

  • 発表論文(Yamaza et al. Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice. Blood. 2009;113:2595-2604)の紹介 Newspaper, magazine

    血液フロンティア  2010.1

     More details

    発表論文(Yamaza et al. Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice. Blood. 2009;113:2595-2604)の紹介

▼display all

Acceptance of Foreign Researchers, etc.

  • 九州大学医学研究院小児外科学分野

    Acceptance period: 2013.3 - Present  

    Nationality:Indonesia

  • 九州大学医学研究院小児外科学分野

    Acceptance period: 2011.4 - 2013.3  

    Nationality:Indonesia

  • 九州大学大学院小児口腔医学分野

    Acceptance period: 2010.10 - 2013.9   (Period):1 month or more

    Nationality:China

    Business entity:Foreign governments, foreign research institutes, international organizations

  • 九州大学大学院歯内疾患制御学分野

    Acceptance period: 2002.4 - 2005.3  

    Nationality:China

Travel Abroad

  • 2011.3

    Staying countory name 1:United States   Staying institution name 1:Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry

  • 2011.3

    Staying countory name 1:United States   Staying institution name 1:89th General Session & Exhibition of the IADR

  • 2010.8 - 2010.9

    Staying countory name 1:United States   Staying institution name 1:Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry

  • 2009.10

    Staying countory name 1:United States   Staying institution name 1:The 59th Annual Meeting of American Society of Human Genetics

  • 2009.10

    Staying countory name 1:United States   Staying institution name 1:Department of Anatomy, Biochemistry & Physiology, University of Hawaii School of Medicine

  • 2009.10

    Staying countory name 1:United States   Staying institution name 1:The 32nd Annual Meeting of Society of Craniofacial Genetics

    Staying institution name 2:SCG Smposium, Hot topic in the Topics, New Breakthroughs in Craniofacial Genetics

  • 2009.8 - 2009.9

    Staying countory name 1:United States   Staying institution name 1:Center for Craniofacial Molecular Biology, University of Southern California

  • 2008.11

    Staying countory name 1:China   Staying institution name 1:International Conference on Frontiers of Oral and Craniofacial Research

  • 2006.4 - 2009.3

    Staying countory name 1:United States   Staying institution name 1:Center for Craniofacial Molecular Biology, University of Southern California

  • 2005.8 - 2006.4

    Staying countory name 1:United States   Staying institution name 1:Nartional Institute of Dental and Craniofacial Research, National Institutes of Health

▼display all

Year of medical license acquisition

  • 1994