記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jaci.2020.05.022

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/art.41052

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-019-51149-1

記述言語：英語  

DOI： 10.1080/14397595.2018.1438093

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2169/internalmedicine.8946-17

記述言語：英語   掲載種別：研究論文（学術雑誌）  

To examine genes expressed specifically in labial salivary glands (LSGs) of patients with Sjögren's syndrome (SS) in comparison with those of patients with immunoglobulin (Ig)G4-related disease (IgG4-RD), and to identify the genes involved in the pathogenesis of SS. Gene expression in LSGs of SS patients, IgG4-RD patients and healthy controls (HC) was analysed by cDNA microarray. Quantitative polymerase chain reaction (qPCR) was used to validate the up-regulation of differentially expressed genes (DEGs) in SS. Protein production of the validated gene in LSGs was examined by immunofluorescence (IF) assay. The association of molecular functions of the gene with the pathological conditions in SS was examined using peripheral blood lymphocytes. Among 1320 DEGs up-regulated in SS, qPCR confirmed the up-regulation of NR4A2 in LSGs of SS compared with IgG4-RD. IF staining showed higher production of NR4A2 in nuclei of CD4⁺ T cells and interleukin (IL)-17-producing cells in LSGs of SS, compared with IgG4-RD. Over-expression of NR4A2 mRNA was observed in peripheral CD4⁺ T cells of SS patients, compared with HC. Nuclear NR4A2 expression in T helper type 17 (Th17)-polarized CD4⁺ T cells determined by cellular IF was significantly higher in SS than in HC. Importazole, an inhibitor of importin-β, inhibited nuclear transport of NR4A2 and Th17 polarization along with IL-21 expression in naive CD4⁺ T cells under Th17-polarizing conditions, but did not alter retinoic acid receptor-related orphan receptor C (RORC) expression. NR4A2 seems to promote Th17 polarization via increased expression and intranuclear localization in CD4⁺ T cells of SS patients, which could play a critical role in the pathogenesis of SS.

DOI： 10.1111/cei.13000

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-017-01661-z

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0173017

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/srep42413

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1136/annrheumdis-2016-209139

記述言語：英語  

DOI： 10.1007/82_2016_40

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3109/14397595.2016.1148225

記述言語：英語  

Objectives: Küttner tumour (KT), so-called chronic sclerosing sialoadenitis, is characterised by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis independent of sialolith formation. However, recent studies have indicated that some patients with KT develop high serum levels of IgG4 and infiltration of IgG4-positive plasma cells, namely IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease. The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS. Materials and Methods: Fifty-four patients pathologically diagnosed with KT or chronic sialoadenitis were divided into two groups according to the presence or absence of sialolith (KT-S (+) or KT-S (-), respectively). Results: There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups. All patients in the KT-S (+) group showed unilateral swelling without infiltration of IgG4-positive plasma cells or a history of other IgG4-related diseases (IgG4-RD), while those in the KT-S (-) group showed bilateral swelling (37.5%), strong infiltration of IgG4-positive plasma cells (87.5%) and a history of other IgG4-RD (12.5%). Conclusions: These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

DOI： 10.1111/odi.12259

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語  

Objectives: Recently, the use of saliva as a diagnostic tool has gained considerable attention because it is non-invasive and easy to perform repeatedly. In this study, we focused on soluble molecules in saliva to establish a new diagnostic method for xerostomia. Materials and Methods: Saliva was obtained from 90 patients with Sjögren's syndrome (SS), 22 patients with xerostomia associated with neurogenic/neuropsychiatric disorders and drugs (XND), 30 patients with radiation-induced xerostomia (RX), and 36 healthy controls. Concentrations of helper T (Th) cytokines in saliva were measured by flow cytometric analysis. Concentrations of secretory IgA (SIgA) and chromogranin A (CgA) were measured by ELISA. Results: Unstimulated and stimulated whole saliva from patients with SS, XND, and RX was significantly reduced compared with controls. Th1 and Th2 cytokines from SS patients were significantly higher than controls. Furthermore, Th2 cytokines were closely associated with strong lymphocytic accumulation in salivary glands from SS patients, while Th1 and Th17 cytokines were negatively associated. SIgA levels were not significantly different between all patient groups and controls. CgA levels from XND patients were significantly higher than controls. Conclusions: The measurement of cytokines, CgA, and SIgA in saliva is suggested to be useful for the diagnosis of xerostomia and also to reveal disease status.

DOI： 10.1111/odi.12252

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.clim.2014.10.008

記述言語：英語  

DOI： 10.1016/j.jaut.2013.07.007

記述言語：英語  

DOI： 10.1016/j.ijom.2014.06.014

記述言語：英語  

DOI： 10.1038/bmt.2012.100

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1136/annrheumdis-2012-201477

記述言語：英語  

DOI： 10.1111/j.1601-0825.2012.01923.x

記述言語：英語  

The aim of this study was to investigate the initiation and progression of autoimmune damage in the lesions of labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining the selective localization of T helper (Th) subsets such as Th1, Th2, Th17 regulatory T cells (T _regs) and follicular T helper cells (Tfh). The expression of cytokines and transcription factors associated with these Th subsets in the LSGs from 54 SS patients and 16 healthy controls was examined using real-time polymerase chain reaction (PCR) and immunostaining. Additionally, infiltrating lymphocytes without germinal centre (GC ^-) and with GC (GC ⁺) in the LSGs specimens from eight SS patients were extracted selectively by laser capture microdissection (LCM). The mRNA expression of these molecules was compared between the two sample groups of GC ^- and GC ⁺ by real-time PCR. The mRNA expression of cytokines and transcription factors of all T helper (Th) subsets in the LSGs from the SS patients was increased significantly in comparison with controls. In LSGs from the SS patients, Th2 and Tfh was associated closely with strong lymphocytic infiltration; however, Th1, Th17 and T _regs was not. In the selectively extracted lesions of LSGs, Th1 and Th17-related molecules were detected strongly in the GC ^-, while Th2 and Tfh-related molecules were detected in the GC ⁺. In contrast, no significant association with strong lymphocytic infiltration was observed in T _reg-related molecules. These results indicate that SS has selective localization of Th subsets such as Th1, Th2, Th17 and Tfh in the LSGs, which is associated closely with disease severity and/or status. SS might be initiated by Th1 and Th17 cells, and then progressed by Th2 and Tfh cells via GC formation.

DOI： 10.1111/j.1365-2249.2012.04606.x

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/ar3924

記述言語：英語   掲載種別：研究論文（学術雑誌）  

To investigate the pathogenesis of localized autoimmune damage in Sjögren's syndrome (SS) by examining the expression patterns of cytokines, chemokines and chemokine receptors at sites of autoimmune damage. mRNA expression of these molecules in the labial salivary glands (LSGs) and peripheral blood mononuclear cells (PBMCs) from 36 SS patients was examined using a real-time polymerase chain reaction-based method. Subsets of the infiltrating lymphocytes and chemokines/chemokine receptors expression in the LSG specimens were examined by immunohistochemistry. Cytokines/chemokine concentrations in the saliva were analysed using flow cytometry or enzyme-linked immunosorbent assay. mRNA expression of T helper type 1 (Th1) cytokines, chemokines and chemokine receptors was higher in LSGs than in PBMCs. In contrast, mRNA expression of Th2 cytokines, chemokines [thymus and activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22)] and chemokine receptor (CCR4) was associated closely with strong lymphocytic accumulation in LSGs. Furthermore, TARC and MDC were detected immunohistochemically in/around the ductal epithelial cells in LSGs, whereas CCR4 was detected on infiltrating lymphocytes. The concentrations of these cytokines/chemokines were significantly higher in the saliva from SS patients than those from controls, and the concentrations of Th2 cytokines/chemokines were associated closely with strong lymphocytic accumulation in LSGs. These results suggest that SS might be initiated and/or maintained by Th1 and Th17 cells and progress in association with Th2 cells via the interaction between particular chemokines/chemokine receptors. Furthermore, the measurement of cytokines/chemokines in saliva is suggested to be useful for diagnosis and also to reveal disease status.

DOI： 10.1111/j.1365-2249.2012.04587.x

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/art.33320

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: IgG4-related tubulointerstitial nephritis (TIN) shows characteristic serum IgG4 elevation and increased IgG4-positive plasma cells in the renal interstitium, and inclusion of TIN as an IgG4-related systemic disease has been suggested. IgG4 is the rarest IgG subclass and is a Th2-dependent isotype with low affinity for target antigen. Although the pathogenesis of this disease has not been elucidated, positive serum immune complex and hypocomplementemia in some patients with this disease suggest that immune complex mechanisms are involved in the causation of this disease. Method:We selected 20 cases of histological diagnosed TIN. These cases were etiologically different and included 4 cases of IgG4-related TIN.We extracted RNAfrom paraffin embedded biopsied kidney and evaluated expression levels of various cytokines for each case by real time PCR. Results: Comparison of cytokine production patterns among different disease-associated TINs revealed that IgG4-related TIN exhibited a quite distinct pattern. On the one hand, there was no expression of IL-2, IFN-γ, IL-17 and IL-6, whereas production of IL-4, IL-10 and TGF-β was, on the other hand, remarkably increased in IgG4-related TIN. Conclusion: Based on these cytokine production results, Th2 and Treg appear to play a central role in IgG4-related TIN.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10165-007-0010-3

記述言語：英語  

DOI： 10.1111/j.1600-0714.2006.00442.x

出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Objectives: To investigate the use of an oral moisture meter to aid in the diagnosis of Sjögren's syndrome (SS) by measuring the moisture values and salivary flow rate (SFR) simultaneously. Methods: The SFR and moisture values of the dorsum of the tongue and buccal mucosa were measured in 40 patients with SS and 29 healthy controls using an oral moisture meter. In addition, a visual analogue scale (VAS) was used to determine the degree of subjective oral symptoms (xerostomia, decreased saliva production, drinking during eating, oral pain, dysphagia, and dysgeusia). Results: The moisture values of the dorsum of the tongue and buccal mucosa were significantly lower in SS patients than in healthy subjects (both p < 0.01). SFR, especially when measured by the spitting test, correlated positively with the moisture values of the dorsum of the tongue (p < 0.0001) and buccal mucosa (p < 0.0003). Furthermore, the sensitivity, specificity, and accuracy of the oral moisture meter measurements of the dorsum of the tongue and buccal mucosa were 92.5%, 68.9%, and 82.6%, and 70.0%, 82.8%, and 73.9%, respectively. The moisture values of the dorsum of the tongue had a moderate negative correlation with the VAS scores of secondary subjective oral symptoms of xerostomia (oral pain, dysphagia, and dysgeusia), whereas a weak negative correlation was observed for subjective oral symptoms directly related to xerostomia (xerostomia and decreased saliva production). Conclusions: The oral moisture meter accurately reflected the results of the SFR tests and chronic subjective oral symptoms, and therefore might be a diagnostic criterion for SS.

DOI： 10.1016/j.ajoms.2024.02.007

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Pathology Research and Practice  

Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the OGTs, but it is even rarer and has a worse prognosis. The precise characteristics of PIOC, especially in immunohistochemical features and its pathogenesis, remain unclear. We characterized a case of PIOC arising from the left mandible, in which histopathological findings showed a transition from the odontogenic keratocyst to the carcinoma. Remarkably, the tumor lesion of this PIOC prominently exhibits malignant attributes, including invasive growth of carcinoma cell infiltration into the bone tissue, an elevated Ki-67 index, and lower signal for CK13 and higher signal for CK17 compared with the non-tumor region, histopathologically and immunohistopathologically. Further immunohistochemical analyses demonstrated increased expression of ADP-ribosylation factor (ARF)-like 4c (ARL4C) (accompanying expression of β-catenin in the nucleus) and yes-associated protein (YAP) in the tumor lesion. On the other hand, YAP was expressed and the expression of ARL4C was hardly detected in the non-tumor region. In addition, quantitative RT-PCR analysis using RNAs and dot blot analysis using genomic DNA showed the activation of Wnt/β-catenin signaling and epigenetic alterations, such as an increase of 5mC levels and a decrease of 5hmC levels, in the tumor lesion. A DNA microarray and a gene set enrichment analysis demonstrated that various types of intracellular signaling would be activated and several kinds of cellular functions would be altered in the pathogenesis of PIOC. Experiments with the GSK-3 inhibitor revealed that β-catenin pathway increased not only mRNA levels of ankyrin repeat domain1 (ANKRD1) but also protein levels of YAP and transcriptional co-activator with PDZ-binding motif (TAZ) in oral squamous cell carcinoma cell lines. These results suggested that further activation of YAP signaling by Wnt/β-catenin signaling may be associated with the pathogenesis of PIOC deriving from odontogenic keratocyst in which YAP signaling is activated.

DOI： 10.1016/j.prp.2024.155420

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記述言語：日本語   出版者・発行元：日本口腔顎顔面外傷学会  

記述言語：その他   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Unilateral scissor bite is one of the rare forms of malocclusion that is accompanied by deep bite and collapsed arch. This report describes the treatment of unilateral scissors bite improved by maxillary and mandibular posterior segmental osteotomy with orthodontic treatment. The patient was a 16-year-old woman with unilateral collapsed maxillary and mandibular arch and a scissor bite of the right buccal segment, and without facial asymmetry. At first, intrusion of right maxillary molars with implant miniscrew was planned, but failure to move. To improve, posterior segmental subapical maxillary osteotomy and mandibular corticotomy were applied without changing facial appearance. Following the surgery, the expansion of the collapsed right mandibular segment bucally using an appliance during comprehensive orthodontic treatment was planned. There was no sensory or motor paralysis. After post-surgical orthodontic treatment, her occlusion improved without alteration of facial appearance and disorder of her speech. Transverse widths at the maxillary premolars and first molars were nearly stable over the 4 years postoperative interval in our patient, and her overall long-term stability showed excellent results. To our knowledge, this case was the first case to combinate two segmental subapical osteotomies without Le Fort I and sagittal split ramous osteotomy. The results indicate that this technique is useful for unilateral expansion of distorted mandibular alveolar process and maxillary and mandibular subapical osteotomy with subsequent orthodontic treatment can be used to successfully treat unilateral scissor bite.

DOI： 10.1016/j.ajoms.2024.01.006

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記述言語：英語   出版者・発行元：Cellular Signalling  

Previous studies have demonstrated that extracellular vesicles (EVs) from dental pulp stem cells (DPSCs), which release abundant hepatocyte growth factor (HGF) and transforming growth factor-β1 (TGF-β1), contribute to the pathogenesis of Sjögren's syndrome (SS). However, depending on the condition of DPSCs, this effect is often not achieved. In this study, we established induced pluripotent stem (iPS) cells highly capable of releasing HGF and TGF-β1 and iPS cells barely capable of releasing them, and administered each EV to SS model mice to see if there was a difference in therapeutic effect. EVs were collected from each iPS cell and their characteristics and shapes were examined. When they were administered to SS model mice, the EVs from iPS cells with higher concentrations of HGF and TGF-β1 showed significantly reduced inflammatory cell infiltration in salivary gland tissues, increased saliva volume, and decreased anti-SS-A and anti-SS-B antibodies. A comprehensive search of microRNA arrays for differences among those EVs revealed that EVs from iPS cells with higher concentrations of HGF and TGF-β1 contained more of the let-7 family. Thereafter, we examined the expression of toll-like receptors (TLRs), which are said to be regulated by the let-7 family, by qPCR, and found decreased TLR4 expression. Focusing on MAPK, a downstream signaling pathway, we examined cytokine concentrations in mouse macrophage culture supernatants and Western blotting of murine splenic tissues and found higher concentrations of anti-inflammatory cytokines in the EVs-treated group and decreased TLR4, NF-κB and phosphorylation (p)-p-38 MAPK expression by Western blotting. Alternatively, p-Smad2/3 was upregulated in the EVs-treated group. Our findings suggest that the let-7 family in EVs may suppress the expression of TLR4 and NF-κB, which may be involved in the suppression of MAPK-mediated pro-inflammatory cytokine production.

DOI： 10.1016/j.cellsig.2023.110980

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記述言語：日本語   出版者・発行元：日本口腔顎顔面外傷学会  

DOI： 10.24787/jsomft.23.1_15

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記述言語：日本語   出版者・発行元：九州矯正歯科学会  

18歳の女性.前歯で食べものを咬み切れないことを主訴に九州大学病院矯正歯科を受診した.左側Angle III級,右側Angle I級で上下顎骨右方偏位を伴う非対称の骨格性III級前歯部開咬,long face type,顎変形症の成長終了後女性症例と診断した.上顎両側小臼歯抜歯による上顎前歯の舌側傾斜および上下顎骨切り術により治療を行うこととした.5年間の動的治療により側貌の改善と正常な前歯部被蓋の獲得,Angle II級の臼歯関係となり調和のとれた歯列咬合と側貌プロファイルが得られ保定開始2年3ヵ月において安定性を示した.(著者抄録)

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers in Immunology  

Background: Cancer immunotherapy targeting CD8+ T cells has made remarkable progress, even for oral squamous cell carcinoma (OSCC), a heterogeneous epithelial tumor without a substantial increase in the overall survival rate over the past decade. However, the therapeutic effects remain limited due to therapy resistance. Thus, a more comprehensive understanding of the roles of CD4+ T cells and B cells is crucial for more robust development of cancer immunotherapy. Methods: In this study, we examined immune responses and effector functions of CD4+ T cells, CD8+ T cells and B cells infiltrating in OSCC lesions using single-cell RNA sequencing analysis, T cell receptor (TCR) and B cell receptor (BCR) repertoire sequencing analysis, and multi-color immunofluorescence staining. Finally, two Kaplan-Meier curves and several Cox proportional hazards models were constructed for the survival analysis. Results: We observed expansion of CD4+ cytotoxic T lymphocytes (CTLs) expressing granzymes, which are reported to induce cell apoptosis, with a unique gene expression patterns. CD4+ CTLs also expressed CXCL13, which is a B cell chemoattractant. Cell–cell communication analysis and multi-color immunofluorescence staining demonstrated potential interactions between CD4+ CTLs and B cells, particularly IgD- CD27- double negative (DN) B cells. Expansion of CD4+ CTLs, DN B cells, and their contacts has been reported in T and B cell-activated diseases, including IgG4-related disease and COVID-19. Notably, we observed upregulation of several inhibitory receptor genes including CTLA-4 in CD4+ CTLs, which possibly dampened T and B cell activity. We next demonstrated comprehensive delineation of the potential for CD8+ T cell differentiation towards dysfunctional states. Furthermore, prognostic analysis revealed unfavorable outcomes of patients with a high proportion of CD4+ CTLs in OSCC lesions. Conclusion: Our study provides a dynamic landscape of lymphocytes and demonstrates a systemic investigation of CD4+ CTL effects infiltrating into OSCC lesions, which may share some pathogenesis reported in severe T and B cell-activated diseases such as autoimmune and infectious diseases.

DOI： 10.3389/fimmu.2023.1305783

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記述言語：その他   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Objectives: Consensus has not yet been reached on the therapy for medication-related osteonecrosis of the jaw (MRONJ). We assessed the effectiveness of conservative surgical management, which involves removing the necrotic bone and performing a gingivectomy, followed by localized cleaning to facilitate the separation of the sequestrum. Additionally, we revalidated the treatment algorithm utilized by our department. Methods: We examined 160 patients diagnosed with MRONJ at three hospitals. The data for this study were collected retrospectively. These patients were followed up for a minimum of 2 years. Results: The outcome 2 years after starting conservative surgical management was: cure: 117 cases; improvement: 22 cases; unchanged: 12 cases; and deterioration: 9 cases. The cure rate was 72.3% and 83.0% at 2 and 5 years after therapy initiation, respectively, and significantly lower at age ≥ 74 years compared to age < 74 years (P < 0.001), with malignant tumour as the primary disease when compared to osteoporosis (P < 0.001), and with ≥ 4 years of administration compared to < 4 years (P = 0.0301). On multivariate analysis, the trigger (P < 0.05), primary disease (P = 0.001), and administration period (P < 0.01) were independent prognostic factors. Conclusions: Conservative surgical management is effective for MRONJ regardless of stage, especially in patients with age < 74 years, osteoporosis, and short drug-administration periods, and could become a first-line therapy for all stages.

DOI： 10.1016/j.ajoms.2023.11.001

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記述言語：その他   掲載種別：研究論文（学術雑誌）   出版者・発行元：Biochimica et Biophysica Acta - Molecular Cell Research  

Salivary glands are physiologically orchestrated by the coordinated balance between cell differentiation, proliferation, apoptosis, and interactions between epithelial, mesenchymal endothelial, and neuronal cells, and they are frequent sites of manifestations of Sjögren's syndrome (SS) or IgG4-related disease (IgG4-RD). However, little is known about salivary gland homeostasis and its involvement in those diseases. Inhibitor of DNA binding/differentiation 4 (Id4) is an Id protein involved in the transcriptional control of many biological events, including differentiation. Studies of Id4-deficient mice revealed that Id4-deficient submandibular glands were smaller and exhibited accelerated differentiation, compared with those from wild-type littermates. In addition, dry mouth symptoms and Th17 expansion in splenocytes were also observed in the absence of Id4. Furthermore, Id4 levels in the salivary glands of patients with IgG4-RD, but not SS, were significantly decreased compared with those of healthy controls. miRNA-mRNA integrated analysis demonstrated that miR-486-5p was upregulated in IgG4-RD patients and that it might regulate Id4 in the lesion sites. Together, these results provide evidence for the inhibitory role of Id4 in salivary differentiation, and a critical association between Id4 downregulation and IgG4-RD.

DOI： 10.1016/j.bbamcr.2022.119404

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記述言語：英語   出版者・発行元：Spandidos Publications  

Mixed tumor of the skin (MTS) is a rare neoplasm derived from the sweat glands with a reported frequency of 0.01-0.098% among all primary skin tumors. MTS often occurs in the head and neck region and is characterized by a mixture of epithelial, myoepithelial and stromal components. MTS also shows various morphological patterns, thus the presence of variants with rare components and its rarity make the clinical diagnosis even more difficult. A 47-year-old man was referred due to a painless, slowly growing, exophytic swelling intracutaneous mass of the upper lip. Magnetic resonance imaging revealed that the mass was a solid tumor with a fatty component in the proximal portion, while the distal portion was cystic and possibly contained highly viscous fluid. The mass was located between the skin and the orbicularis oris muscle in the upper lip. Excisional biopsy was performed and the lesion showed two intriguing features: A tumor with extensive lipomatous stroma and some large cysts. It was histopathologically diagnosed as lipomatous MTS with cystic formation in the upper lip. No evident signs of recurrence were observed during follow-up. The present report describes this case and includes a brief literature review of reported cases in the lip, since MTS can be confused with various skin lesions in clinical settings due to this rarity. Recognition by clinicians of different variants of MTSs, including the present case, is important for preventing erroneous diagnosis and treatment.

DOI： 10.3892/etm.2022.11600

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記述言語：その他   掲載種別：研究論文（学術雑誌）   出版者・発行元：Biomedicines  

An alternative source of mesenchymal stem cells has recently been discovered: dental pulp stem cells (DPSCs), including deciduous teeth, which can thus comprise potential tools for regenerative medicine. DPSCs derive from the neural crest and are normally implicated in dentin homeostasis. The clinical application of mesenchymal stem cells (MSCs) involving DPSCs contains various limitations, such as high cost, low safety, and cell handling issues, as well as invasive sample collection procedures. Although MSCs implantation offers favorable outcomes on specific diseases, implanted MSCs cannot survive for a long period. It is thus considered that their mediated mechanism of action involves paracrine effects. It has been recently reported that secreted molecules in DPSCs-conditioned media (DPSC-CM) contain various trophic factors and cytokines and that DPSC-CM are effective in models of various diseases. In the current study, we focus on the characteristics of DPSC-CM and their therapeutic potential against various disorders.

DOI： 10.3390/biomedicines10051049

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Pathology International  

Patients with plasma cell type idiopathic multicentric Castleman disease (PC-iMCD) often show elevated serum IgG4 levels and IgG4-positive cell infiltration in tissues due to overproduction of interleukin-6, and may meet the diagnostic criteria for IgG4-related disease (IgG4-RD). Although PC-iMCD has been listed as a major exclusion disease for IgG4-RD, distinguishing between these diseases is challenging due to a lack of highly specific diagnostic biomarkers. In 2020, we proposed exclusion criteria of IgG4-RD mimickers. In this paper, we validated the accuracy of the criteria in excluding one of the mimickers, PC-iMCD, from IgG4-RD. Validation was performed on 57 PC-iMCD patients (39 presenting lymph node lesions and 19 with lung lesions) and 29 IgG4-RD patients (22 presenting lymph node lesions and seven with lung lesions). According to our results, 20.5&#37; of the PC-iMCD patients with lymph node lesions and 42.1&#37; of those with lung lesions met the diagnostic criteria for IgG4-RD. All these patients with PC-iMCD were excluded from a diagnosis of IgG4-RD by the proposed criteria. Additionally, 6.9&#37; of IgG4-RD patients met the exclusion criteria. Thus, if the exclusion criteria are met, diagnosis should be made based on a combination of findings including organ distribution of disease, response to steroid therapy, and other pathological findings.

DOI： 10.1111/pin.13185

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記述言語：英語   出版者・発行元：John Wiley & Sons Australia, Ltd  

2020年に提唱された、IgG4関連疾患(IgG4-RD)の類似疾患除外基準の有用性について検討するため、IgG4-RD類似疾患の1つである形質細胞型特発性多中心性Casthleman病(PC-iMCD)患者を対象に検証した。病理組織学的/免疫組織学的検査ならびに血清学的検査で調べた結果、PC-iMCD患者ではリンパ節病変患者が39例(男性25例、女性14例、年齢34～89歳)、肺病変患者が19例(男性8例、女性11例、年齢26～73歳)に認められた。一方、IgG4-RD患者ではリンパ節病変患者が22例(男性7例、女性15例、年齢47～81歳)、肺病変患者が7例(男性7例、年齢39～77歳)であった。また、リンパ節病変を伴うPC-iMCD患者の20.5%と、肺病変を伴うPC-iMCD患者の42.1%はIgG4-RDの診断基準を満たしていたが、提唱された除外基準により、全例がIgG4-RDの診断から除外され、IgG4-RD患者の6.9%は、除外基準を満たしていることが明らかにされた。以上より、提唱されたIgG4-RD類似疾患除外基準は100%の感度と93.1%の特異度を有し、IgG4-RDの診断に有用と結論付けられた。

記述言語：その他   掲載種別：研究論文（学術雑誌）  

<title>Abstract</title><sec>
<title>Background</title>
Sjögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflammatory cytokines, which leads to a positive feedback loop establishment. The study aimed to evaluate the effects of secreted factors derived from dental pulp stem cells (DPSCs) or bone marrow mesenchymal stem cells (BMMSCs) on hyposalivation in SS and to investigate the mechanism involved.


</sec><sec>
<title>Methods</title>
Eighty percent confluent stem cells were replenished with serum-free Dulbecco’s modified Eagle’s medium and incubated for 48 h; following which, conditioned media from DPSCs (DPSC-CM) and BMMSCs (BMMSC-CM) were collected. Cytokine array analysis was performed to assess the types of cytokines present in the media. Flow cytometric analysis was performed to evaluate the number of activated T cells cultured in DPSC-CM or BMMSC-CM. Subsequently, DPSC-CM or BMMSC-CM was administered to an SS mouse model. The mice were categorized into the following groups (<italic>n</italic> = 6 each): non-treatment, Dulbecco’s modified Eagle’s medium (−), BMMSC-CM, and DPSC-CM. Histological analysis of the salivary glands was performed. The gene and protein expression levels of cytokines associated with T helper subsets in the submandibular glands (SMGs) were evaluated.


</sec><sec>
<title>Results</title>
DPSC-CM contained more secreted factors with tissue-regenerating mechanisms, such as cell proliferation, anti-inflammatory effects, and immunomodulatory effects. DPSC-CM was more effective in suppressing the activated T cells than other groups in the flow cytometric analysis. The stimulated salivary flow rate increased in SS mice with DPSC-CM compared with that in the other groups. In addition, the number of inflammation sites in SMGs of the mice administered with DPSC-CM was lower than that in the other groups. The expression levels of <italic>interleukin</italic> (<italic>Il</italic>)<italic>-10</italic> and transforming growth factor-β1 were upregulated in the DPSC-CM group, whereas those of <italic>Il-4</italic> and <italic>Il-17a</italic> were downregulated. The DPSC-CM-administered group presented with a significantly increased percentage of regulatory T (Treg) cells and a significantly decreased percentage of type 17 Th (Th17) cells compared with the other groups.


</sec><sec>
<title>Conclusions</title>
These results indicated that DPSC-CM ameliorated SS by promoting Treg cell differentiation and inhibiting Th17 cell differentiation in the mouse spleen.


</sec>

DOI： 10.1186/s13287-021-02236-6

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Arthritis and Rheumatology  

OBJECTIVE: IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition that can affect multiple organs. We previously demonstrated that human Toll-like receptor 7 (huTLR7)-transgenic C57BL/6 mice showed elevated serum IgG1 levels and inflammation with fibrosis in the salivary glands (SGs), lungs, and pancreas. Moreover, we observed extensive TLR7+ CD163+ M2 macrophage infiltration in SGs from IgG4-RD patients. Here, we examined the fibrotic mechanism via the TLR7 pathway. METHODS: Gene expression in SGs from huTLR7-transgenic mice and IgG4-RD patients was analyzed using DNA microarrays. We extracted the common upregulated TLR7-related genes in SGs from huTLR7-transgenic mice and IgG4-RD patients. Finally, we investigated the interaction between CD163+ M2 macrophages and fibroblasts before/after stimulation with the TLR7 agonist loxoribine. RESULTS: In huTLR7-transgenic mice and IgG4-RD patients, IL-1 receptor-associated kinase 3 (IRAK3) and IRAK4 were significantly overexpressed. Real-time PCR validated the upregulation of only IRAK4 in IgG4-RD patients compared with the other groups. IRAK4 was strongly detected in/around germinal centers in SGs from IgG4-DS patients alone. Double immunofluorescence staining showed that IRAK4-positive cells were mainly co-localized with CD163+ M2 macrophages in SGs. After stimulation with loxoribine, CD163+ M2 macrophages exhibited significantly enhanced expression of IRAK4 and nuclear factor kappa B (NF-κB) and increased supernatant concentrations of fibrotic cytokines. Finally, we confirmed that the number of fibroblasts was increased by culture with the supernatant of CD163+ M2 macrophages following stimulation with loxoribine. CONCLUSION: CD163+ M2 macrophages promote fibrosis in IgG4-RD by increasing the production of fibrotic cytokines via TLR7/IRAK4/NF-κB signaling. This article is protected by copyright. All rights reserved.

DOI： 10.1002/art.42043

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Scopus

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijms22179475

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語  

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.reth.2021.01.006

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12865-020-00361-0

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語  

DOI： 10.1080/14397595.2019.1576271

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/odi.13255

記述言語：英語  

DOI： 10.5125/jkaoms.2020.46.1.3

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000018300

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/14397595.2019.1632061

記述言語：日本語  

記述言語：日本語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/intimm/dxy075

記述言語：日本語  

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-018-28405-x

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Low-grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report.
Low-grade myofibroblastic sarcoma (LGMS) is a rare intermediate tumor, which rarely metastasizes and has myofibroblastic differentiation in various sites. It is particularly associated with the tongue in the head and neck region. The lack of any pathological features means it is difficult to make a conclusive diagnosis of LGMS. The immunohistochemical features and genomic rearrangements, including SS18-SSXs and MYH9-USP6s and the genetic mutations of cancer-associated genes, including APC, CTNNB1, EGFR, KRAS, PIK3CA and p53 were examined in a case of LGMS arising in the tip of the tongue. Immunohistochemically, the tumor cells were positive for alpha-smooth muscle actin and vimentin, as in previous reports. They demonstrated neither genomic rearrangements nor point mutations of cancer-associated genes. Although several tumor cells demonstrated intravascular invasion, the MIB-l labeling index of the cells was the same as the original lesion. To the best of our knowledge, this is the first case report of LGMS arising in the tip of the tongue with intravascular invasion.

DOI： 10.3892/ol.2018.9115

記述言語：英語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/jbm4.10013

記述言語：英語  

DOI： 10.1016/j.ijom.2018.01.004

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.26508/lsa.201800050

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1136/annrheumdis-2016-210758

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/srep28110

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/MD.0000000000002853

記述言語：英語  

DOI： 10.1007/978-4-431-55687-9_3

記述言語：英語  

DOI： 10.1007/978-4-431-55687-9_3

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjogren's Syndrome: Comparison with IgG4-Related Disease

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13075-015-0751-x

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12957-015-0644-0

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/or.2015.3838

記述言語：その他  

IL-33 Secreted by M2 Macrophage Promotes the Pathogenesis of IgG4-Related Disease

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjogren's Syndrome: Comparison with IgG4-Related Disease

記述言語：日本語  

記述言語：英語  

DOI： 10.1097/MD.0000000000000704

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12957-015-0459-z

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ajoms.2014.04.011

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/art.38748

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0101156

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3109/14397595.2013.843765

記述言語：英語  

Mikulicz’s disease (MD) was considered to be a subtype of Sjögren’s syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentrations and suggested that MD is an “IgG4-related disease” and distinguishable from SS. We examined the clinical and serological features of MD and SS in detail to determine the ways in which the two conditions can be differentiated. MD can be diagnosed quickly and simply using diagnostic criteria such as serum IgG4 values and the presence of IgG4+ cells in the salivary glands, in conjunction with salivary gland imaging, sonography, and CT scans. Glucocorticoid therapy of MD reduces IgG and IgG4 levels and improves salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD.

DOI： 10.1007/978-4-431-54228-5_13

記述言語：英語  

Mikulicz’s disease (MD) was considered to be a subtype of Sjögren’s syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentrations and suggested that MD is an “IgG4-related disease” and distinguishable from SS. We examined the clinical and serological features of MD and SS in detail to determine the ways in which the two conditions can be differentiated. MD can be diagnosed quickly and simply using diagnostic criteria such as serum IgG4 values and the presence of IgG4+ cells in the salivary glands, in conjunction with salivary gland imaging, sonography, and CT scans. Glucocorticoid therapy of MD reduces IgG and IgG4 levels and improves salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD.

DOI： 10.1007/978-4-431-54228-5_13

記述言語：英語   掲載種別：研究論文（学術雑誌）  

IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in the target organs, and its molecular mechanism of pathogenesis remains to be clarified. IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease or Küttner's tumor, is included in IgG4-RD and shows clinical and histological similarities to Sjögren's syndrome (SS). In this review, we focus on the selective localization and respective functions of Th cell subsets and discuss the differences between IgG4-DS and SS to clarify the clinical and pathogenic mechanisms of these diseases.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00784-012-0905-z

記述言語：英語   掲載種別：研究論文（学術雑誌）  

ANALYSIS OF MOLECULAR MECHANISM IN IGG4-RELATED DISEASE: COMPARISON WITH SJOGREN'S SYNDROME

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ajoms.2012.05.018

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10165-012-0812-9

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：その他  

Molecular Mechanism of IgG4 Class Switch Recombination in IgG4-Related Disease.

記述言語：その他  

In vitro induction of specific CD8+ T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma.

DOI： 10.1016/j.canlet.2012.02.016

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tripleo.2009.02.032

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語  

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記述言語：日本語   著書種別：学術書

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開催年月日： 2023年3月

記述言語：日本語  

開催地：金沢   国名：日本国  

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記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2022年9月

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開催年月日： 2022年9月 - 2022年10月

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開催地：オンデマンド配信   国名：日本国  

開催年月日： 2022年9月 - 2022年10月

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開催地：オンデマンド配信   国名：日本国  

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記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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開催年月日： 2022年7月

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開催地：WEB   国名：日本国  

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記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

開催地：福岡   国名：日本国  

開催年月日： 2021年10月

記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

開催地：WEB   国名：日本国  

開催年月日： 2021年10月 - 2022年10月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：WEB   国名：日本国  

開催年月日： 2021年10月 - 2022年10月

記述言語：日本語  

開催地：WEB   国名：日本国  

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開催年月日： 2021年10月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：WEB   国名：日本国  

開催年月日： 2021年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：WEB   国名：日本国  

開催年月日： 2019年11月 - 2020年11月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：幕張   国名：日本国  

開催年月日： 2019年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2016年10月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2015年10月

記述言語：英語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

国名：日本国  

開催年月日： 2015年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：東京   国名：日本国  

開催年月日： 2015年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2015年4月

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開催年月日： 2014年5月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：福岡   国名：日本国  

開催年月日： 2014年4月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：福岡   国名：日本国  

開催年月日： 2014年2月 - 2014年3月

記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：Fukuoka   国名：日本国  

開催年月日： 2014年2月

記述言語：英語  

国名：アメリカ合衆国  

開催年月日： 2014年2月

記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

国名：アメリカ合衆国  

開催年月日： 2014年2月

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

開催年月日： 2013年10月

記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：Kyoto   国名：日本国  

開催年月日： 2013年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：大阪   国名：日本国  

開催年月日： 2012年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：横浜   国名：日本国  

開催年月日： 2012年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

開催年月日： 2012年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：京都   国名：日本国  

開催年月日： 2011年6月

会議種別：口頭発表（一般）  

国名：ドイツ連邦共和国  

開催年月日： 2009年3月

会議種別：口頭発表（一般）  

開催地：神戸   国名：日本国  

開催年月日： 2008年7月

会議種別：口頭発表（一般）  

開催地：Tronto   国名：カナダ  

開催年月日： 2008年4月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2008年3月

会議種別：口頭発表（一般）  

開催地：松本   国名：日本国  

開催年月日： 2007年10月

会議種別：口頭発表（一般）  

開催地：Hawaii   国名：アメリカ合衆国  

開催年月日： 2007年9月

会議種別：口頭発表（一般）  

開催地：京都   国名：日本国  

開催年月日： 2007年4月

会議種別：口頭発表（一般）  

開催地：神戸   国名：日本国  

開催年月日： 2006年10月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2006年9月

会議種別：口頭発表（一般）  

開催地：鶴見   国名：日本国  

開催年月日： 2006年8月 - 2006年9月

会議種別：口頭発表（一般）  

開催地：Zagreb   国名：クロアチア共和国  

開催年月日： 2006年7月 - 2006年6月

会議種別：口頭発表（一般）  

国名：オーストラリア連邦  

開催年月日： 2006年5月

会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

開催年月日： 2017年2月

記述言語：英語   会議種別：口頭発表（招待・特別）  

国名：日本国  

開催年月日： 2016年4月

記述言語：英語   会議種別：口頭発表（一般）  

国名：アメリカ合衆国  

開催年月日： 2015年7月

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

開催年月日： 2014年2月 - 2014年3月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2014年2月

記述言語：英語   会議種別：口頭発表（一般）  

国名：アメリカ合衆国  

開催年月日： 2014年2月

記述言語：英語  

国名：アメリカ合衆国  

開催年月日： 2013年10月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2013年10月

記述言語：日本語  

開催地：福岡   国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

開催地：Kyoto   国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

開催地：Kyoto   国名：日本国  

開催年月日： 2013年10月

記述言語：英語  

国名：日本国  

開催年月日： 2013年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

開催年月日： 2013年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2013年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2012年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：新潟   国名：日本国  

開催年月日： 2012年12月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2012年11月

記述言語：英語   会議種別：口頭発表（一般）  

国名：インドネシア共和国  

開催年月日： 2012年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：横浜   国名：日本国  

開催年月日： 2012年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：横浜   国名：日本国  

開催年月日： 2012年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：京都   国名：日本国  

開催年月日： 2012年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

開催年月日： 2011年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：バリ   国名：インドネシア共和国  

開催年月日： 2011年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

開催年月日： 2011年10月

記述言語：日本語  

開催地：大阪   国名：日本国  

開催年月日： 2011年10月

記述言語：日本語  

開催地：広島   国名：日本国  

開催年月日： 2011年9月

記述言語：英語  

開催地：アテネ   国名：ギリシャ共和国  

開催年月日： 2011年9月

記述言語：英語  

開催地：アテネテネ   国名：ギリシャ共和国  

開催年月日： 2011年7月

記述言語：日本語  

開催地：神戸   国名：日本国  

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：京都   国名：日本国  

記述言語：日本語  

開催地：鹿児島   国名：日本国  

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：京都   国名：日本国  

記述言語：日本語  

開催地：金沢   国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   出版者・発行元：(有)科学評論社  

記述言語：その他  

Pathogenesis of IgG4-related disease: a critical review.

DOI： 10.1007/s10266-018-0377-y

種別：大会・シンポジウム等 

参加者数：98

種別：大会・シンポジウム等 

researchmap

種別：審査・学術的助言 

researchmap

種別：大会・シンポジウム等 

参加者数：60

種別：大会・シンポジウム等 

参加者数：65

種別：大会・シンポジウム等 

参加者数：65

種別：査読等 

外国語雑誌　査読論文数：10

国内会議録　査読論文数：3

種別：査読等 

外国語雑誌　査読論文数：10

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：査読等 

外国語雑誌　査読論文数：8

種別：大会・シンポジウム等 

参加者数：150

種別：審査・学術的助言 

種別：査読等 

外国語雑誌　査読論文数：5

種別：査読等 

外国語雑誌　査読論文数：7

種別：査読等 

外国語雑誌　査読論文数：4

種別：大会・シンポジウム等