Faculty Profiles - KIYOSHIMA TAMOTSU

Information

写真a

KIYOSHIMA TAMOTSU

Organization

Faculty of Dental Science Department of Dental Science Professor
School of Dentistry Department of Dentistry（Concurrent）
Graduate School of Dental Science （Concurrent）
Graduate School of Dental Science Department of Dental Science（Concurrent）

Contact information

Tel

0926426328

Profile

<Research> 1.Regeneration of the tooth Three approaches as follows is aimed at the regeneration of the tooth. 1) Elucidation of the mechanism in the odontogenesis 2) Analysis the tissue-specific mechanism in aging process 3) Isolation and identification of the tissue-specific stem cells 2.Analysis of differences between oral cancers through cellular and molecular biological approaches This research is aimed at the development of the new gene therapy method for oral cancer using the gene considered to relate to the profiles of oral cancers. <Education> (Undergraduate School) Oral pathology: (Lecture) The generalities and the particulars (Exercise) The explanation of the pathological specimens meeting each unit of a lecture, and the instruction of the observation under a microscope Outline of the dental and medical science: Introduction of the dental science Comprehensive dental science Research exposure: For 3rd and sixth grades Inspection and exercise are performed to the student who expects experience of research activities in the spring and/or summer vacations, within limited condition that is fully taken the safe side into consideration. (Graduate School) The graduate students will study a part of above-mentioned research and write papers on it under instruction to be a "researcher" in the future. Moreover, they will be involved also in autopsy or pathological diagnosis of the oral disease from the department of medical examination so as to understand the fundamentals of pathology.

External link

Degree

D.D.S., Ph.D.

Research History

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Research Interests・Research Keywords

Research theme：Molecular and genetic investigation on the development and regeneration of the tooth

Keyword：regeneration of the tooth, tooth development, odontogenesis, epithelial-mesenchymal interaction

Research period： 2000.1
Research theme：Analysis of differentially expressing genes among oral squamous cell carcinomas and gene-associated functions

Keyword：oral carcinoma, invasion, metastasis, transcriptional regulation, Protein-Protein Interaction

Research period： 2000.1
Research theme：Age-dependent change of the periodontal tissue

Keyword：tooth regeneration, periodontal tissue, aging, cell scenesence, protein interaction

Research period： 2000.1

Awards

The Jeremy Jass Prize for Research Excellence in Pathology

2023.1 5th Joint Winter Meeting of The Pathological Society and The Royal Society of Medicine The Jeremy Jass Prize for Research Excellence in Pathology: Each year, The Journal of Pathology awards the Jeremy Jass Prize for Research Excellence in Pathology to the authors of the paper published in the preceding year that is considered best by the Editorial Team of the Journal.

Papers

Wnt/(3-catenin-YAP (3-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst Reviewed International coauthorship International journal

Nakako, Y; Hasegawa, K; Fujii, S; Kami, Y; Sakamoto, T; Sakamoto, M; Moriyama, M; Kurppa, KJ; Heikinheimo, K; Yoshiura, K; Kawano, S; Kiyoshima, T

PATHOLOGY RESEARCH AND PRACTICE 260 155420 2024.8 （ ISSN:0344-0338 eISSN:1618-0631 ）

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Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Pathology Research and Practice

Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the OGTs, but it is even rarer and has a worse prognosis. The precise characteristics of PIOC, especially in immunohistochemical features and its pathogenesis, remain unclear. We characterized a case of PIOC arising from the left mandible, in which histopathological findings showed a transition from the odontogenic keratocyst to the carcinoma. Remarkably, the tumor lesion of this PIOC prominently exhibits malignant attributes, including invasive growth of carcinoma cell infiltration into the bone tissue, an elevated Ki-67 index, and lower signal for CK13 and higher signal for CK17 compared with the non-tumor region, histopathologically and immunohistopathologically. Further immunohistochemical analyses demonstrated increased expression of ADP-ribosylation factor (ARF)-like 4c (ARL4C) (accompanying expression of β-catenin in the nucleus) and yes-associated protein (YAP) in the tumor lesion. On the other hand, YAP was expressed and the expression of ARL4C was hardly detected in the non-tumor region. In addition, quantitative RT-PCR analysis using RNAs and dot blot analysis using genomic DNA showed the activation of Wnt/β-catenin signaling and epigenetic alterations, such as an increase of 5mC levels and a decrease of 5hmC levels, in the tumor lesion. A DNA microarray and a gene set enrichment analysis demonstrated that various types of intracellular signaling would be activated and several kinds of cellular functions would be altered in the pathogenesis of PIOC. Experiments with the GSK-3 inhibitor revealed that β-catenin pathway increased not only mRNA levels of ankyrin repeat domain1 (ANKRD1) but also protein levels of YAP and transcriptional co-activator with PDZ-binding motif (TAZ) in oral squamous cell carcinoma cell lines. These results suggested that further activation of YAP signaling by Wnt/β-catenin signaling may be associated with the pathogenesis of PIOC deriving from odontogenic keratocyst in which YAP signaling is activated.

DOI： 10.1016/j.prp.2024.155420

Web of Science

Scopus

PubMed
Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication Reviewed International coauthorship International journal

Fujii, S; Hasegawa, K; Maehara, T; Kurppa, KJ; Heikinheimo, K; Warner, KA; Tajiri, Y; Maruyama, S; Nor, JE; Tanuma, JI; Kawano, S; Kiyoshima, T

PATHOLOGY RESEARCH AND PRACTICE 254 155148 2024.2 （ ISSN:0344-0338 eISSN:1618-0631 ）

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Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. ACC is composed of myoepithelial and epithelial neoplastic cells which grow slowly and have a tendency for neural invasion. The long term prognosis is still relatively poor. Although several gene abnormalities, such as fusions involving MYB or MYBL1 oncogenes and the transcription factor gene NFIB, and overexpression of KIT have been reported in ACC, their precise functions in the pathogenesis of ACC remain unclear. We recently demonstrated that the elevated expression of Semaphorin 3A (SEMA3A), specifically expressed in myoepithelial neoplastic cells, might function as a novel oncogene-related molecule to enhance cell proliferation through activated AKT signaling in 9/10 (90%) ACC cases. In the current study, the patient with ACC whose tumor was negative for SEMA3A in the previous study, revisited our hospital with late metastasis of ACC to the cervical lymph node eight years after surgical resection of the primary tumor. We characterized this recurrent ACC, and compared it with the primary ACC using immunohistochemical methods. In the recurrent ACC, the duct lining epithelial cells, not myoepithelial neoplastic cells, showed an elevated Ki-67 index and increased cell membrane expression of C-kit, along with the expression of phosphorylated ERK. Late metastasis ACC specimens were not positive for β-catenin and lymphocyte enhancer binding factor 1 (LEF1), which were detected in the nuclei of perineural infiltrating cells in primary ACC cells. In addition, experiments with the GSK-3 inhibitor revealed that β-catenin pathway suppressed not only KIT expression but also proliferation of ACC cells. Moreover, stem cell factor (SCF; also known as KIT ligand, KITL) induced ERK activation in ACC cells. These results suggest that inactivation of Wnt/β-catenin signaling may promote C-kit-ERK signaling and cell proliferation of in metastatic ACC.

DOI： 10.1016/j.prp.2024.155148

Web of Science

Scopus

PubMed
Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation Reviewed International journal

#Thinh Thi Kim Truong, @Shinsuke Fujii, #Ryoko Nagano, @Kana Hasegawa, #Megumi Kokura, @Yuta Chiba, @Keigo Yoshizaki, @Satoshi Fukumoto, @Tamotsu Kiyoshima.

Biochemical and biophysical research communications. 679 167 - 174 2023.9

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DOI： 10.1016/j.bbrc.2023.09.014.
The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis Invited Reviewed International journal

@SHINSUKE FUJII, @TAMOTSU KIYOSHIMA.

Pathology international. 73 ( 6 ) 217 - 233 2023.6

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DOI： 10.1111/pin.13325.
Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation Reviewed International journal

#Dania Zuhier Ragheb Alkhatib, #Thinh Thi Kim Truong, @Shinsuke Fujii, @Kana Hasegawa, #Ryoko Nagano, @Yudai Tajiri, @Tamotsu Kiyoshima.

Pathology, research and practice. 246 154493 2023.6

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DOI： 10.1016/j.prp.2023.154493.
Prediction of nodal metastasis based on intraoral sonographic findings of the primary lesion in early-stage tongue cancer Reviewed International journal

@S Kawano, @T Hattori, @Y Mikami, @T Chikui, @T Kawazu, @T Sakamoto, @Y Maruse, @S Tanaka, @E Hamada, #M Hiwatashi, #Y Shiraishi, @K Oobu, @T Kiyoshima, @S Nakamura

International journal of oral and maxillofacial surgery. 52 ( 5 ) 515 - 523 2023.5

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DOI： 10.1016/j.ijom.2022.08.021
Wnt signaling promotes tooth germ development through YAP1-TGF-β signaling Reviewed International journal

630 64 - 70 2022.9

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Tooth germ development involves continuous and sequential steps with reciprocal interactions between odontogenic epithelium and the adjacent mesenchyme. Several growth factors, including Wnt, are essential for tooth germ development. Molecular mechanisms underlying Wnt/β-catenin-regulated tooth germ development are poorly understood. In tooth germ rudiments culture, we recently demonstrated that Semaphorin 3A (Sema3A), an axonal guidance factor, stimulation reversed Wnt/β-catenin signaling-dependent decreased cell proliferation but did not completely rescue the morphological anomalies of tooth germ, suggesting that an uncharacterized signaling pathway may be essential in Wnt/β-catenin signaling-dependent tooth germ development. Herein, an enrichment analysis using DNA microarray data, which was obtained in our previous research, revealed that Wnt/β-catenin signaling negatively regulates YAP1 and/or TGF-β signalings. In odontogenic epithelial cells and tooth germ rudiments, Wnt/β-catenin signaling activation reduced YAP1 expression, thereby suppressing YAP1 and TGF-β signalings sequentially. Additionally, YAP1 signaling induced TGF-β2 expression to promote TGF-β signaling in the cells. Finally, Wnt/β-catenin signaling-dependent disorganized tooth germ development, in which YAP1 signaling was suppressed, was reversed by TGF-β stimulation. These results suggest that Wnt/β-catenin signaling contributes to the tooth germ development through YAP1-TGF-β signaling.

DOI： 10.1016/j.bbrc.2022.09.012
Lipomatous mixed tumor of the skin with cystic formation affecting the upper lip: a case report Reviewed International journal

#RYOKO NAGANO, @SHINSUKE FUJII, @HIROKO WADA, @MAYU MATSUMURA-KAWASHIMA, @YURIE MIKAMI, @MASAFUMI MORIYAMA, @TORU CHIKUI, @KAZUNORI YOSHIURA, @SEIJI NAKAMURA, @TAMOTSU KIYOSHIMA.

Experimental and Therapeutic Medicine 24 ( 5 ) 664 2022.9

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DOI： 10.3892/etm.2022.11600

Other Link： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477013/

Repository Public URL： https://hdl.handle.net/2324/7173430
The Semaphorin 3A-AKT axis-mediated cell proliferation in salivary gland morphogenesis and adenoid cystic carcinoma pathogenesis Reviewed International journal

@Shinsuke Fujii, #Tatsufumi Fujimoto, @Kana Hasegawa, #Ryoko Nagano, #Takuma Ishibashi, @Kari J.Kurppa, @Yurie Mikami, #Megumi Kokura, @Yudai Tajiri, @Toshiro Kibe, @Hiroko Wada, @Naohisa Wada, @Shosei Kishida, @Yoshinori Higuchi, @Tamotsu Kiyoshima.

Pathology - Research and Practice in press 2022.8

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DOI： 10.1016/j.prp.2022.153991
Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma Reviewed International journal

@Kana Hasegawa, @Shinsuke Fujii, @Kari J Kurppa, @Takashi Maehara, @Kazunari Oobu, @Seiji Nakamura, @Tamotsu Kiyoshima

Pathology - Research and Practice 235 153909 2022.4

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DOI： 10.1016/j.prp.2022.153909

Other Link： https://www.sciencedirect.com/science/article/pii/S0344033822001534?via%3Dihub

Repository Public URL： https://hdl.handle.net/2324/7178626
RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation Reviewed International journal

@Shinsuke Fujii, #Takuma Ishibashi, #Megumi Kokura, #Tatsufumi Fujimoto, @Shinji Matsumoto, @Satsuki Shidara, @Kari J Kurppa, @Judith Pape, @Javier Caton, @Peter R Morgan, @Kristiina Heikinheimo, @Akira Kikuchi, @Eijiro Jimi, @Tamotsu Kiyoshima

J Pathol. 256 ( 1 ) 119 - 133 2022.1

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DOI： 10.1002/path.5814
YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation Reviewed International journal

@Kana Hasegawa, @Shinsuke Fujii, @Shinji Matsumoto, #Yudai Tajiri, @Akira Kikuchi, @Tamotsu Kiyoshima

J Pathol 253 ( 1 ) 80 - 93 2021.1

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DOI： 10.1002/path.5553

Repository Public URL： http://hdl.handle.net/2324/4481560
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Invited Reviewed International journal

@Shinsuke Fujii, #Yudai Tajiri, @Kana Hasegawa, @Shinji Matsumoto, @Reiko U. Yoshimoto, @Hiroko Wada, @Shosei Kishida, @Mizuho A. Kido, @Hiromasa Yoshikawa, @Satoru Ozeki, @Tamotsu Kiyoshima

Laboratory Investigation 100 ( 2 ) 311 - 323 2020.2

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DOI： 10.1038/s41374-019-0357-z.

Repository Public URL： https://hdl.handle.net/2324/4123614
Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development. Reviewed International journal

9 2019.3

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Odontomas, developmental anomalies of tooth germ, frequently occur in familial adenomatous polyposis patients with activated Wnt/β-catenin signaling. However, roles of Wnt/β-catenin signaling in odontomas or odontogenic cells are unclear. Herein, we investigated β-catenin expression in odontomas and functions of Wnt/β-catenin signaling in tooth germ development. β-catenin frequently accumulated in nucleus and/or cellular cytoplasm of odontogenic epithelial cells in human odontoma specimens, immunohistochemically. Wnt/β-catenin signaling inhibited odontogenic epithelial cell proliferation in both cell line and tooth germ development, while inducing immature epithelial bud formation. We identified Semaphorin 3A (Sema3A) as a downstream molecule of Wnt/β-catenin signaling and showed that Wnt/β-catenin signaling-dependent reduction of Sema3A expression resulted in suppressed odontogenic epithelial cell proliferation. Sema3A expression is required in appropriate epithelial budding morphogenesis. These results suggest that Wnt/β-catenin signaling negatively regulates odontogenic epithelial cell proliferation and tooth germ development through decreased-Sema3A expression, and aberrant activation of Wnt/β-catenin signaling may associate with odontoma formation.

DOI： 10.1038/s41598-019-39686-1
Low-grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report. Reviewed International journal

@Yurie Mikami, @Shinsuke Fujii, @Ken-Ichi Kohashi, @Yuichi Yamada, @Masafumi Moriyama, @Shintaro Kawano, @Seiji Nakamura, @Yoshinao Oda, @Tamotsu Kiyoshima

Oncology letters. 16 ( 3 ) 3889 - 3894 2018.9

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DOI： 10.3892/ol.2018.9115

Repository Public URL： https://hdl.handle.net/2324/7178628
GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas. Reviewed International journal

J Cancer Res Clin Oncol 143 ( 8 ) 1381 - 1393 2017.3

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DOI： 10.1007/s00432-017-2398-2

Other Link： https://link.springer.com/article/10.1007/s00432-017-2398-2

Repository Public URL： https://hdl.handle.net/2324/7178627
Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) expression and possible function in mouse tooth germ development Reviewed International journal

Kana Hasegawa, Hiroko Wada, Kengo Nagata, Hiroaki Fujiwara, Naohisa Wada, Hirotaka Someya, Yurie Mikami, Hidetaka Sakai, Tamotsu Kiyoshima

Int. J. Mol. Med. 47 ( 4 ) 375 - 387 2016.8

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DOI： 10.1007/s10735-016-9680-5
Thymosin beta 4 is associated with RUNX2 expression via the Smad and Akt signaling pathways in mouse dental epithelial cells. Reviewed International journal

Hirotaka Someya, Fujiwara Hiroaki, Kengo Nagata, Hiroko Wada, Kana Hasegawa, Yurie Mikami, Akiko Jinno, Hidetaka Sakai, Kiyoshi Koyano, Tamotsu Kiyoshima

Int. J. Mol. Med. 35 ( 5 ) 1169 - 1178 2015.5

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DOI： doi: 10.3892/ijmm.2015.2118.
Itm2a expression in the developing mouse first lower molar, and the subcellular localization of itm2a in mouse dental epithelial cells. Reviewed International journal

Makiko Kihara, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Fujiwara Hiroaki, Kana Hasegawa, Hirotaka Someya, Ichiro Takahashi, Hidetaka Sakai

PLoS One. 9 ( 7 ) e103928 2014.7

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DOI： doi: 10.1371/journal.pone.0103928.
Induction of dental epithelial cell differentiation marker gene expression in non-odontogenic human keratinocytes by transfection with thymosin beta 4. Reviewed International journal

Tamotsu Kiyoshima, Fujiwara Hiroaki, Kengo Nagata, Hiroko Wada, Yukiko Okuma, Maho Shiotsuka, Makiko Kihara, Kana Hasegawa, Hirotaka Someya, Hidetaka Sakai

Stem Cell Research 12 ( 1 ) 309 - 322 2014.1

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DOI： doi: 10.1016/j.scr.2013.11.006.
The expression and function of thymosin beta 10 in tooth germ development. Reviewed International journal

Maho Shiotsuka, Hiroko Wada, Tamotsu Kiyoshima, Kengo Nagata, Fujiwara Hiroaki, Makiko Kihara, Kana Hasegawa, Hirotaka Someya, Ichiro Takahashi, Hidetaka Sakai

Int J Dev Biol 57 ( 11-12 ) 873 - 883 2013.12

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DOI： doi: 10.1387/ijdb.120240hs.
Chemoresistance to Concanamycin A1 in Human Oral Squamous Cell Carcinoma Is Attenuated by an HDAC Inhibitor Partly via Suppression of Bcl-2 Expression Reviewed International journal

Tamotsu Kiyoshima, Hisato Yoshida, Hiroko Wada, Kengo Nagata, Fujiwara Hiroaki, Makiko Kihara, Kana Hasegawa, Hirotaka Someya, Hidetaka Sakai

PLOS ONE 8 ( 11 ) 2013.11

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DOI： 10.1371/journal.pone.0080998
Immunohistochemical Expression of Thymosin β4 in Ameloblastomas and Odontomas. Reviewed International journal

28 ( 6 ) 775 - 786 2013.6

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DOI： doi: 10.3892/ijo.2012.1594.
Multiple functional involvement of Thymosin beta-4 in tooth germ development Reviewed International journal

Yukiko Okuma, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Kengo Nagata, Hiroko Wada, Fujiwara Hiroaki, Haruyoshi Yamaza, Kazuaki Nonaka, Hidetaka Sakai

HISTOCHEMISTRY AND CELL BIOLOGY 139 ( 2 ) 355 - 370 2013.2

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DOI： 10.1007/s00418-012-1033-1
Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblasts. Reviewed International journal

Int. J. Mol. Med. 30 ( 5 ) 1007 - 1012 2012.11

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DOI： doi: 10.3892/ijmm.2012.1102.
STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma. Reviewed International journal

Int. J. Oncol. 41 ( 5 ) 1577 - 1586 2012.11

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DOI： doi: 10.3892/ijo.2012.1594.
Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. Reviewed International journal

Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H.

BMC Dev Biol. 2010.11

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Transcription promoter activity of the human S100A7 gene in oral squamous cell carcinoma cell lines. Reviewed International journal

Hideaki Fukuzawa, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Satoru Ozeki, Hidetaka Sakai

Biochem, Biophys.Acta 2006.4

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Effect of SCCA1 and SCCA2 on the suppression of TNF-a-induced cell death by impeding the release of mitochondrial cytochrome c in oral squamous cell carcinoma cell line. Reviewed International journal

Ken-ichiro Hashimoto, Tamotsu Kiyoshima, Kou Matsuo, Satoru Ozeki, Hidetaka Sakai

Tumor Biol. 26 ( 4 ) 165 - 172 2005.7

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DOI： 10.1159/000086949
In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue. Reviewed International journal

Ogasawara T, Yoshimine Y, Kiyoshima T, Kobayashi I, Matsuo K, Akamine A, Sakai H

J Periodontal Res. 39 ( 1 ) 42 - 49 2004.1

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In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue.

DOI： 10.1111/j.1600-0765.2004.00699.x
An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements. Reviewed International journal

Kiyoshima T, Yamauchi M, Wong C, Jheon A, Ganss B, Sodek J.

Gene 2002.10

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An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements.
Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. Reviewed International journal

Okamura K, Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Ishibashi H, Komatsu S, Rasul AM, Sakai H.

Oral Oncol. 38 ( 3 ) 244 - 250 2002.4

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Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland.

DOI： 10.1016/S1368-8375(01)00049-5
In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar. Reviewed International journal

Wada H, Kobayashi I, Yamaza H, Matsuo K, Kiyoshima T, Akhtar M, Sakai T, Koyano K, Sakai H.

Histochem J. 34 ( 3-4 ) 105 - 109 2002.3

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In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar.

DOI： 10.1023/A:1020930228303
Expression of Set-alpha during morphogenesis of mouse lower first molar Reviewed International journal

Yamaza H, Matsuo K, Kobayashi I, Wada H, Kiyoshima T, Akhtar M, Ishibashi Y, Sakai T, Akamine A, Sakai H.

Histochem J. 33 ( 8 ) 437 - 441 2001.8

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Expression of Set-alpha during morphogenesis of mouse lower first molar

DOI： 10.1023/A:1014491111628
Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands Reviewed International journal

Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Okamura K, Komatsu S, Rasul AM, Sakai H.

Oral Oncol. 37 ( 3 ) 315 - 322 2001.4

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Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands

DOI： 10.1016/S1368-8375(00)00083-X
Localization of activated caspase-3-positive and apoptotic cells in the developing tooth germ of the mouse lower first molar Reviewed International journal

Shigemura N, Kiyoshima T, Sakai T, Matsuo K, Momoi T, Yamaza H, Kobayashi I, Wada H, Akamine A, Sakai H.

Histochem J. 33 ( 5 ) 253 - 258 2001.3

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Localization of activated caspase-3-positive and apoptotic cells in the developing tooth germ of the mouse lower first molar

DOI： 10.1023/A:1017900305661
Detection of differentially expressed genes in the early developmental stage of the mouse mandible Reviewed International journal

Yamaza H, Matsuo K, Kiyoshima T, Shigemura N, Kobayashi I, Wada H, Akamime A, Sakai H.

Int J Dev Biol. 45 ( 4 ) 675 - 680 2001.1

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Detection of differentially expressed genes in the early developmental stage of the mouse mandible
Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan Reviewed International journal

Shima K, Kobayashi I, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H.

Br J Oral Maxillofac Surg. 2000.10

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Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan
Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate. Reviewed International journal

Li C.Y., Shirasuna K., Ishibashi H., Nakayama H. and Kiyoshima T.

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 90 ( 4 ) 460 - 465 2000.10

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Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate.

DOI： 10.1067/moe.2000.108099
Age-dependent changes in the distribution of BrdU- and TUNEL-positive cells in the murine gingival tissue Reviewed International journal

Sakai T, Kiyoshima T, Kobayashi I, Moroi R, Ibuki T, Nagadome M, Terada Y, Sakai H.

J Periodontol. 70 ( 9 ) 973 - 981 1999.9

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Age-dependent changes in the distribution of BrdU- and TUNEL-positive cells in the murine gingival tissue.

DOI： 10.1902/jop.1999.70.9.973
Prevalence of Epstein-Barr virus in oral squamous cell carcinoma Reviewed International journal

Kobayashi I, Shima K, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H.

J Pathol. 189 ( 1 ) 34 - 39 1999.9

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Prevalence of Epstein-Barr virus in oral squamous cell carcinoma.

DOI： 10.1002/(SICI)1096-9896(199909)189:1<34::AID-PATH391>3.0.CO;2-4
The distribution of BrdU- and TUNEL-positive cells during odontogenesis in mouse lower first molars International journal

Shigemura N, Kiyoshima T, Kobayashi I, Matsuo K, Yamaza H, Akamine A, Sakai H.

Histochem J. 31 ( 6 ) 367 - 377 1999.7

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The distribution of BrdU- and TUNEL-positive cells during odontogenesis in mouse lower first molars.

DOI： 10.1023/A:1003796023992
Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland. Reviewed International journal

Kobayashi I., Kiyoshima T., Ozeki S., Shima K., Shigemura N., Matsuo K. and Sakai H.

J. Oral Pathol. Med. 28 ( 6 ) 282 - 286 1999.7

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Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland.
Immunohistochemical localization of laminin, collagen type IV and heparan sulfate proteoglycan in human colorectal adenocarcinoma: correlation with local invasive pattern and lymph node metastasis Reviewed International journal

Kiyoshima T., Kobayashi, I., Matsuo K., Ishibashi Y., Miyoshi A., Akashi Y. and Sakai H.

Acta Histochemica et Cytochemica 31 ( 1 ) 39 - 47 1998.1

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Immunohistochemical localization of laminin, collagen type IV and heparan sulfate proteoglycan in human colorectal adenocarcinoma: correlation with local invasive pattern and lymph node metastasis
Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analysed by computer image analyser: correlation with histological grade and metastatic behaviour Reviewed International journal

Kazuhiko Okamura, Ieyoshi Kobayashi, Kou Matsuo, Tamotsu Kiyoshima, Kenji Yamamoto, Akira Miyoshi, Hidetaka Sakai

HISTOPATHOLOGY 31 ( 6 ) 540 - 548 1997.12

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Salivary Duct Carcinoma with Sebaceous Cell Differentiation arising from Parotid Gland: Histological, Immunohistochemical and Ultrastructural Analyses of a Case. Reviewed International journal

Kobayashi I., Matsuo K., Kiyoshima T., Shinohara M. and Sakai H.

Oral Med. Pathol. 2 1997.3

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Salivary Duct Carcinoma with Sebaceous Cell Differentiation arising from Parotid Gland: Histological, Immunohistochemical and Ultrastructural Analyses of a Case.
Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analyzed by computor image analyzer: correlation with the histological grade and the metastatic activity of carcinoma. Reviewed International journal

Okamura K., Kobayashi I., Matsuo K., Kiyoshima T., Yamamoto K., Miyoshi A. and Sakai H.

Histopathology 31 1997.3

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Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analyzed by computor image analyzer: correlation with the histological grade and the metastatic activity of carcinoma.
Immunohistochemical localization of cathepsins D and E in human gastric cancer: A possible correlation with local invasive and metastatic activities of carcinoma cells Reviewed International journal

Kou Matsuo, Ieyoshi Kobayashi, Takayuki TSUKUBA, Tamotsu Kiyoshima, Yukiko Ishibashi, Akira Miyoshi, Kenji Yamamoto, Hidetaka Sakai

HUMAN PATHOLOGY 27 ( 2 ) 184 - 190 1996.2

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Phosphorylation of Serine 536 of p65(RelA) Downregulates Inflammatory Responses Reviewed International journal

Aoki, T; Gao, J; Li, A; Huang, F; Tu, YR; Wu, W; Matsuda, M; Kiyoshima, T; Nishimura, F; Jimi, E

INFLAMMATION 2024.9 （ ISSN:0360-3997 eISSN:1573-2576 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Inflammation

Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various genes involved in inflammatory diseases and immune responses. Recently, a novel transcriptional regulatory mechanism of NF-κB involving the phosphorylation of serine 536 (534 in mice; S534) of its p65 subunit was reported; however, further research is required to elucidate the physiological role of S534 phosphorylation. Therefore, we generated S534A knock-in (KI) mice, in which the S534 of p65 was substituted with alanine. Similar to the wild-type (WT) mice, S534A KI mice developed normally. After stimulation with tumor necrosis factor α (TNFα), mouse embryonic fibroblasts (MEFs) derived from S534A KI mice exhibited increased target gene expression compared with that in the WT MEFs, which was induced by long-term binding of p65 to DNA. According to comprehensive gene expression analysis after stimulation with TNFα, the expression of genes p65ted to inflammatory and immune responses was increased, and the expression of genes p65ted to lipolysis was decreased in S534A KI MEFs. Analyses of a periodontal disease model established using WT and S534A KI mice revealed that alveolar bone resorption was enhanced in S534A KI mice owing to an increase in the number of osteoclasts, which was not attributed to the differentiation of osteoclast precursor cells but to an increased expression of interleukin-1β and receptor activator of NF-κB ligand in the periodontal tissue. Hence, phosphorylation of S536 negatively regulates inflammatory responses in vitro and in vivo.

DOI： 10.1007/s10753-024-02140-0

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Nuclear factor- K B p65 subunit determines the fate of aging epithelial cells Reviewed International journal

Gao, T; Kawabata, Y; Kiyoshima, T; Jimi, E

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 722 150143 2024.8 （ ISSN:0006-291X eISSN:1090-2104 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications

Nuclear factor (NF)-κB signaling is not only important for the immune and inflammatory responses but also for the normal development of epithelial cells, such as those in the skin and tooth. Here, we generated epithelial cell-specific p65-deficient (p65Δepi−/−) mice to analyze the roles of NF-κB signaling in epithelial cell developent. Notably, p65Δepi−/− mice exhibited no abnormalities in their appearance compared to the control (p65flox/flox) littermates. Furthermore, no major changes were observed in the skin, hair growth, and shape and color of the incisors and molars. However, 65 % of p65Δepi−/− mice exhibited corneal thickening after 8 weeks of age, and 30 % of p65Δepi−/− mice exhibited hair growth from the mandibular incisors around 24 weeks of age. No hair growth was observed at 36 and 42 weeks of age. However, micro-computed tomography images revealed a large cavity below the mandibular incisors extending to the root of the incisor. Histological analysis revealed that the cavity was occupied by a connective tissue containing hair-like structures with many dark brown granules that disappeared after melanin bleaching, confirming the presence of hair. Although inflammatory cells were also observed near the eruption site of the incisor teeth of p65Δepi−/− mice, no major disturbance was observed in the arrangement of enamel epithelial cells. Overall, these results highlight the role of p65 in the maintenance of epithelial cell homeostasis during aging.

DOI： 10.1016/j.bbrc.2024.150143

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Correlation between diffusion-weighted image-derived parameters and dynamic contrast-enhanced magnetic resonance imaging-derived parameters in the orofacial region. Reviewed International journal

@Chikui T, @Ohga M, @Kami Y, @Togao O, @Kawano S, @Kiyoshima T, @Yoshiura K.

Acta Radiol Open. 13 ( 3 ) 20584601241244777 2024.3

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DOI： 10.1177/20584601241244777.
The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation Reviewed International journal

57 ( 3 ) 344 - 354 2024.3

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Aim: Cyst formation of the jaws is frequently accompanied by the proliferation of odontogenic epithelial cells located in the periodontal ligament (PDL), which consists of heterozygous cells and includes the most fibroblasts. The lining epithelium of radicular cyst, an odontogenic cyst of inflammatory origin, is derived from the proliferation of the remnants of the Hertwig epithelial root sheath (odontogenic epithelial cell rests of Malassez; ERMs) in the PDL. ERMs are maintained at a lower proliferative state under physiological conditions, but the regulatory mechanisms underlying the inflammation-dependent enhanced-proliferative capabilities of ERMs are not fully understood. The aim of this study was to evaluate the effects of cytokine pathway association between TGF-β signalling and IL-1β signalling on the regulation of odontogenic epithelial cell proliferation using radicular cyst pathological specimens and odontogenic epithelial cell lines.

Methodology: Immunofluorescence analyses were performed to clarify the expression levels of Smad2/3 and Ki-67 in ERMs of 8-week-old mouse molar specimens. In radicular cyst (n = 52) and dentigerous cysts (n = 6) specimens from human patients, the expression of p65 (a main subunit of NF-κB), Smad2/3 and Ki-67 were investigated using immunohistochemical analyses. Odontogenic epithelial cells and PDL fibroblastic cells were co-cultured with or without an inhibitor or siRNAs. Odontogenic epithelial cells were cultured with or without TGF-β1 and IL-1β. The proliferative capabilities and Smad2 phosphorylation levels of odontogenic epithelial cells were examined.

Results: Immunohistochemically, Smad2/3-positivity was increased, and p65-positivity and Ki-67-positivity were decreased both in ERMs and in the epithelial cells in dentigerous cysts, a non-inflammatory developmental cyst. In contrast, p65-positive cells, along with the expression of Ki-67, were increased and Smad2/3-positive cells were decreased in the lining epithelia of radicular cysts. Co-culture experiments with odontogenic epithelial cells and PDL fibroblastic cells revealed that PDL cells-derived TGF-β1/2 and their downstream signalling suppressed odontogenic epithelial cell proliferation. Moreover, TGF-β1 stimulation induced Smad2 phosphorylation and suppressed odontogenic epithelial cell proliferation, while IL-1β stimulation reversed these phenotypes through p65 transactivation.

Conclusions: These results suggest that IL-1β-p65 signalling promotes odontogenic epithelial cell proliferation through suppressing TGF-β-Smad2 signalling, which would be involved in the pathogenesis of radicular cysts.

DOI： 10.1111/iej.14016.
Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication Reviewed International journal

@Fujii S, @Hasegawa K, @Maehara T, @Kurppa KJ, @Heikinheimo K, @Warner KA, @Maruyama S, @Tajiri Y, @Nör JE, @Tanuma JI, @Kawano S, @Kiyoshima T.

254 155148 2024.2

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Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. ACC is composed of myoepithelial and epithelial neoplastic cells which grow slowly and have a tendency for neural invasion. The long term prognosis is still relatively poor. Although several gene abnormalities, such as fusions involving MYB or MYBL1 oncogenes and the transcription factor gene NFIB, and overexpression of KIT have been reported in ACC, their precise functions in the pathogenesis of ACC remain unclear. We recently demonstrated that the elevated expression of Semaphorin 3A (SEMA3A), specifically expressed in myoepithelial neoplastic cells, might function as a novel oncogene-related molecule to enhance cell proliferation through activated AKT signaling in 9/10 (90%) ACC cases. In the current study, the patient with ACC whose tumor was negative for SEMA3A in the previous study, revisited our hospital with late metastasis of ACC to the cervical lymph node eight years after surgical resection of the primary tumor. We characterized this recurrent ACC, and compared it with the primary ACC using immunohistochemical methods. In the recurrent ACC, the duct lining epithelial cells, not myoepithelial neoplastic cells, showed an elevated Ki-67 index and increased cell membrane expression of C-kit, along with the expression of phosphorylated ERK. Late metastasis ACC specimens were not positive for β-catenin and lymphocyte enhancer binding factor 1 (LEF1), which were detected in the nuclei of perineural infiltrating cells in primary ACC cells. In addition, experiments with the GSK-3 inhibitor revealed that β-catenin pathway suppressed not only KIT expression but also proliferation of ACC cells. Moreover, stem cell factor (SCF; also known as KIT ligand, KITL) induced ERK activation in ACC cells. These results suggest that inactivation of Wnt/β-catenin signaling may promote C-kit-ERK signaling and cell proliferation of in metastatic ACC.

DOI： 10.1016/j.prp.2024.155148.
Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease Reviewed International journal

#Koga R, @Maehara T, #Aoyagi R, @Munemura R, @Murakami Y, @Doi A, @Kono M, @Yamamoto H, @Niiro H, @Kiyoshima T, @Tanabe M, @Nakano T, @Matsukuma Y, @Kawano M, @Stone JH, @Pillai S, @Nakamura S, @Kawano S.

Journal of allergy and clinical immunology. 2023.12

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DOI： 10.1016/j.jaci.2023.11.916.
Expansion of CD4+cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and <i>in vitro</i> experiments Reviewed International journal

Chen, H; Sameshima, J; Yokomizo, S; Sueyoshi, T; Nagano, H; Miyahara, Y; Sakamoto, T; Fujii, S; Kiyoshima, T; Guy, T; Nakamura, S; Moriyama, M; Kaneko, N; Kawano, S

FRONTIERS IN IMMUNOLOGY 14 1305783 2023.11 （ ISSN:1664-3224 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers in Immunology

Background: Cancer immunotherapy targeting CD8+ T cells has made remarkable progress, even for oral squamous cell carcinoma (OSCC), a heterogeneous epithelial tumor without a substantial increase in the overall survival rate over the past decade. However, the therapeutic effects remain limited due to therapy resistance. Thus, a more comprehensive understanding of the roles of CD4+ T cells and B cells is crucial for more robust development of cancer immunotherapy. Methods: In this study, we examined immune responses and effector functions of CD4+ T cells, CD8+ T cells and B cells infiltrating in OSCC lesions using single-cell RNA sequencing analysis, T cell receptor (TCR) and B cell receptor (BCR) repertoire sequencing analysis, and multi-color immunofluorescence staining. Finally, two Kaplan-Meier curves and several Cox proportional hazards models were constructed for the survival analysis. Results: We observed expansion of CD4+ cytotoxic T lymphocytes (CTLs) expressing granzymes, which are reported to induce cell apoptosis, with a unique gene expression patterns. CD4+ CTLs also expressed CXCL13, which is a B cell chemoattractant. Cell–cell communication analysis and multi-color immunofluorescence staining demonstrated potential interactions between CD4+ CTLs and B cells, particularly IgD- CD27- double negative (DN) B cells. Expansion of CD4+ CTLs, DN B cells, and their contacts has been reported in T and B cell-activated diseases, including IgG4-related disease and COVID-19. Notably, we observed upregulation of several inhibitory receptor genes including CTLA-4 in CD4+ CTLs, which possibly dampened T and B cell activity. We next demonstrated comprehensive delineation of the potential for CD8+ T cell differentiation towards dysfunctional states. Furthermore, prognostic analysis revealed unfavorable outcomes of patients with a high proportion of CD4+ CTLs in OSCC lesions. Conclusion: Our study provides a dynamic landscape of lymphocytes and demonstrates a systemic investigation of CD4+ CTL effects infiltrating into OSCC lesions, which may share some pathogenesis reported in severe T and B cell-activated diseases such as autoimmune and infectious diseases.

DOI： 10.3389/fimmu.2023.1305783

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Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K Reviewed International journal

#Miyahara Y, #Chen H, @Moriyama M, @Mochizuki K, @Kaneko N, @Haque ASMR, @Chinju A, @Kai K, @Sakamoto M, @Kakizoe-Ishiguro N, @Yamauchi M, @Ogata K, @Kiyoshima T, @Kawano S, @Nakamura S.

Scientific reports 13 ( 1 ) 19320 2023.11

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DOI： 10.1038/s41598-023-46090-3.
Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments Reviewed International journal

#Chen H, #Sameshima J, #Yokomizo S, #Sueyoshi T, #Nagano H, #Miyahara Y, @Sakamoto T, @Fujii S, @Kiyoshima T, @Guy T, @Nakamura S, @Moriyama M, @Kaneko N, @Kawano S.

Frontiers in immunology. 14 1305783 2023.11

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DOI： 10.3389/fimmu.2023.1305783.
Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD Reviewed International journal

#Aoyagi R, @Maehara T, #Koga R, @Munemura R, @Tomonaga T, @Murakami Y, @Doi A, @Yamamoto H, @Kiyoshima T, @Kawano S, @Nakamura S.

Journal of allergy and clinical immunology. 2023.9

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DOI： 10.1016/j.jaci.2023.08.019.
Mandibular metastasis from prostate cancer that clinically mimicked osteosarcoma: A case report Reviewed International journal

Imajo, I; Yamada, T; Fujinaga, T; Nagano, K; Kumamaru, W; Yanai, Y; Chikui, T; Kiyoshima, T

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 35 ( 5 ) 445 - 449 2023.9 （ ISSN:2212-5558 eISSN:2212-5566 ）

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Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Metastatic tumors in the oral cavity are rare, accounting for only 1% of all oral malignancies. The most common site of metastatic tumors in the oral cavity is the mandibular molar region. The primary sites differ between the sexes. Among men, the primary sites are the lung, kidney, liver, and prostate in the order of frequency. Moreover, 11% of jawbone metastases among men originate from the prostate gland. Symptoms differ according to the location of the metastasis; besides, metastases-related imaging findings are nonspecific, making it difficult to reach an accurate diagnosis. Metastatic oral cancer has a poor prognosis; therefore, early diagnosis and treatment are important to improve the survival-rate and quality of life. A 76-year-old male patient was referred to our hospital with complaint of right-sided mandibular swelling and past medical history of adenocarcinoma of the prostate gland. Intraoral examination revealed a hard hemispherical mass on the right mandibular first molar region. Computed tomography showed a well-marginated radiopaque hemisphere mass with a typical sunburst periosteal reaction. Based on the imaging findings, we suspected primary osteosarcoma or metastatic prostate cancer. Histopathological examination of the mandible revealed a glandular structure with atypia similar to that of the primary prostate cancer cells. After prostate specific antigen monitoring therapy, the metastatic cancer did not grow. Metastatic cancers from other organs should be considered in the differential diagnosis of jawbone malignancies because the metastatic cancer might present similarities to the primary cancer in imaging findings, as in the present case that clinically mimicked osteosarcoma.

DOI： 10.1016/j.ajoms.2023.01.009

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Intraosseous synovial sarcoma of the mandible: A case report and review of the literature. Reviewed International journal

@Imajo I, @Yamada T, @Chikui T, @Kiyoshima T, @Ito M, @Kohashi K, @Sakamoto E, @Oda Y.

Oncology letters. 26 ( 1 ) 318 2023.7

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DOI： doi: 10.3892/ol.2023.13904.
p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands Reviewed International journal

@Jing Gao, #Aonan Li, @Shinsuke Fujii, #Fei Huang, @Chihiro Nakatomi, @Ichiro Nakamura, @Hiroaki Honda, @Tamotsu Kiyoshima, @Eijiro Jimi

Scientific reports 13 5144 2023.3

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DOI： 10.1038/s41598-023-32390-1.
Usefulness of reconstructed images of Gd-enhanced 3D gradient echo sequences with compressed sensing for mandibular cancer diagnosis: comparison with CT images and histopathological findings Reviewed International journal

@Kami Y, @Chikui T, @Togao O, @Kawano S, @Fujii S, @Ooga M, @Kiyoshima T, @Yoshiura K.

European radiology 33 ( 2 ) 845 - 853 2023.2

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DOI： 10.1007/s00330-022-09075-w
口腔底と全身のリンパ節にAIDS関連Kaposi肉腫が生じた1例(A case of AIDS-associated Kaposi's sarcoma occurring in the oral cavity and systemic lymph nodes)

Nagano Koki, Yamada Tomohiro, Ishii Kotaro, Fujinaga Takahiro, Shibuya Minami, Yanai Yuta, Kiyoshima Tamotsu, Mori Yoshihide

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 34 ( 4 ) 536 - 541 2022.7 （ ISSN:2212-5558 ）

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Language：English Publisher：エルゼビア・ジャパン(株)

症例は27歳男性で、1ヵ月前に歯肉腫脹で近耳鼻科を受診し、抗生物質を投与されるも改善しなかったため当科へ紹介された。本患者は男性同性愛者であった。副鼻腔炎と扁桃炎の病歴が存在しており就寝時に多少の息苦しさも自覚していた。理学的診察では頸部、後頭部、腋窩領域、鼠径領域に大小の腫瘤が触知され、その性状は無痛性、弾性軟であった。口腔内診察では暗赤色調で弾性軟の腫瘤が歯肉・口蓋の4ヵ所に認められた。画像検査では身体各所のリンパ節腫大などが確認された。後天性免疫不全症候群(AIDS)関連のKaposi肉腫とリンパ腫と臨床診断し、当院の総合内科へ診療を依頼し入院となった。血液検査が行われ、ヒト免疫不全ウイルス(HIV)とヒトヘルペスウイルス8への感染が確証された。さらに頸部リンパ節と歯肉病変の生検でもKaposi肉腫と診断された。抗レトロウイルス療法(ART)と、ペグ化リポソーマルドキソルビシンによる化学療法を開始したところ、病変は縮小するなど治療反応が得られた。ART開始から1年後に当たる現在では口腔と全身リンパ節の病変は部分寛解の状態にあり、ART継続下にあって再発の徴候はみられなかった。
A case of AIDS-associated Kaposi's sarcoma occurring in the oral cavity and systemic lymph nodes Reviewed International journal

Nagano, K; Yamada, T; Ishii, K; Fujinaga, T; Shibuya, M; Yanai, Y; Kiyoshima, T; Mori, Y

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 34 ( 4 ) 536 - 541 2022.7 （ ISSN:2212-5558 eISSN:2212-5566 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Kaposi's sarcoma (KS) is one of the most common malignancies in patients with acquired immunodeficiency syndrome (AIDS). KS is frequently detected in the skin, gastrointestinal tract and oral cavity, but rarely occurs in multiple systemic lymph nodes. Here, we report a case of AIDS-associated KS that occurred in both the oral region and multiple systemic lymph nodes. A 27-year-old man was referred to our department because of a mass in the oral cavity. The main clinical findings included multiple dark red masses in the oral cavity and generalized lymphadenopathy. Blood tests revealed infection with human immunodeficiency virus and human herpes virus 8. The histopathological diagnosis of both the oral masses and cervical lymph nodes was KS. After initiating antiretroviral therapy and chemotherapy with pegylated liposomal doxorubicin the lesions went into partial remission, and there was no sign of relapse 1 year later.

DOI： 10.1016/j.ajoms.2021.11.009

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Distinct disease-specific Tfh cell populations in two different fibrotic diseases: IgG4-related disease and Kimura's disease Reviewed International journal

#Ryusuke Munemura, @TakashiMaehara, #Yuka Murakami, #Risako Koga, #Ryuichi Aoyagi, @Naoki Kaneko, @tsushi Doi, @Cory A. Perugino, @EmanuelDella-Torre, @Takako Saeki, @Yasuharu Sato, @Hidetaka Yamamoto, @Tamotsu Kiyoshima, @John H. Stone, @Shiv Pillai, @SeijiNakamura

J Allergy Clin Immunol. 2022.5

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DOI： 10.1016/j.jaci.2022.03.034
Methotrexate-associated lymphoproliferative disorder affecting the gingiva and intestinal mucosa with intestinal perforation: A case report Reviewed International journal

Fujinaga, T; Ohyama, Y; Nagano, K; Imajo, I; Yamada, T; Kiyoshima, T; Mori, Y

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 34 ( 2 ) 169 - 173 2022.3 （ ISSN:2212-5558 eISSN:2212-5566 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

According to the fourth revised edition of the world health organization classification of hematopoietic tumors, methotrexate (MTX)-associated lymphoproliferative disorder (MTX-LPD), an atypical pathological condition, is categorized under other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs). An 80-year-old woman presented with OIIA-LPDs that simultaneously occurred in the gingiva and intestinal mucosa, causing intestinal perforation requiring emergency surgery. She was referred to our hospital because of poor wound healing after maxillary right first molar extraction. She had been prescribed MTX and prednisolone for rheumatoid arthritis and bisphosphonate for osteoporosis. We diagnosed her with medication-related osteonecrosis of the jaw, as the lesion showed bone exposure with mild redness and swelling of the surrounding gingiva and a cytological result of Class II. However, 9 months later, following the exfoliation of a partial sequestrum of the maxillary right first molar, a rapidly growing mass with gingival necrosis appeared, necessitating a biopsy. Simultaneously, abdominal pain worsened, and computed tomography revealed intestinal perforation; an emergency laparotomy was performed to remove the perforation and the surrounding ulcer-prone area. Histopathological examination of both lesions revealed diffuse large B-cell lymphomas. The final diagnosis was of MTX-LPD, as the mass, gingival necrosis, and residual small intestinal ulcer disappeared 2 months after MTX discontinuation. The exposed bone completely disappeared after 24 months, and no recurrence was noted after 60 months following MTX discontinuation. Although intestinal perforation due to MTX-LPD is extremely rare, patients with RA are immunosuppressed. Therefore, MTX-LPD must be recognized as a dangerous condition that requires careful general monitoring in such patients.

DOI： 10.1016/j.ajoms.2021.08.012

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Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis Reviewed International journal

#Akane Inoue, @Tamotsu Kiyoshima, @Keigo Yoshizaki, @Chihiro Nakatomi, @Mitsushiro Nakatomi, @Hayato Ohshima, @Masashi Shin, @Jing Gao, @Kanji Tsuru, @Koji Okabe, @Ichiro Nakamura, @Hiroaki Honda, @Miho Matsuda, @Ichiro Takahashi, @Eijiro Jimi

Bone 154 116210 2021.9

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DOI： 10.1016/j.bone.2021.116210.
Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway Reviewed International journal

2021.9

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Oral malignant melanoma, which frequently invades the hard palate or maxillary bone, is extremely rare and has a poor prognosis. Bone morphogenetic protein (BMP) is abundantly expressed in bone matrix and is highly expressed in malignant melanoma, inducing an aggressive phenotype. We examined the role of BMP signaling in the acquisition of an aggressive phenotype in melanoma cells in vitro and in vivo. In five cases, immunohistochemistry indicated the phosphorylation of Smad1/5 (p-Smad1/5) in the nuclei of melanoma cells. In the B16 mouse and A2058 human melanoma cell lines, BMP2, BMP4, or BMP7 induces morphological changes accompanied by the downregulation of E-cadherin, and the upregulation of N-cadherin and Snail, markers of epithelial–mesenchymal transition (EMT). BMP2 also stimulates cell invasion by increasing matrix metalloproteinase activity in B16 cells. These effects were canceled by the addition of LDN193189, a specific inhibitor of Smad1/5 signaling. In vivo, the injection of B16 cells expressing constitutively activated ALK3 enhanced zygoma destruction in comparison to empty B16 cells by increasing osteoclast numbers. These results suggest that the activation of BMP signaling induces EMT, thus driving the acquisition of an aggressive phenotype in malignant melanoma.
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders of the oral floor induced by methotrexate and tofacitinib: A case report Invited Reviewed International journal

@Sugiyama G, @Ohyama Y, @Yamada T, @Ishii K, @Kumamaru W, #Sumimoto Y, @Kiyoshima T, @Niiro H, @Mori Y.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 33 ( 3 ) 297 - 301 2021.5

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DOI： 10.1016/j.ajoms.2020.12.002
Elevated Expression of Protease-Activated Receptor 1 via ΔNp63 Down-Regulation Contributes to Nodal Metastasis in Oral Squamous Cell Carcinoma Reviewed International journal

50 ( 2 ) 163 - 170 2021.2

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Protease-activated receptor 1 (PAR1) is known as a thrombin receptor. Recent studies have reported PAR1 expression in various malignancies; however, its role in oral squamous cell carcinoma (OSCC) requires clarification. A previous study showed that down-regulation of ΔNp63, a homolog of p53, augments PAR1 expression in OSCC. In the present study, the association of PAR1 expression with clinicopathological findings in OSCC was examined retrospectively. Expression of PAR1, thrombin, and ΔNp63 was examined immunohistochemically in OSCC specimens. Patients were divided into three groups based on the expression pattern of PAR1 at the invasive front: group A, PAR1-negative in both cancer and stromal cells; group B, positive in stromal cells but negative in cancer cells; group C, positive in both cancer and stromal cells. Histologically high-grade tumours were significantly more common in group C. Patients in group C had the highest incidence rate of nodal metastasis (P<0.001) and a lower survival rate (P=0.085) than those in the other groups. At the invasive front, in group C, thrombin was expressed but ΔNp63 expression was weak. These results indicate that increased PAR1 expression in both cancer and stromal cells could be a useful predictive marker of nodal metastasis and that ΔNp63 is involved in regulating PAR1 expression.

DOI： 10.1016/j.ijom.2020.04.021.
p130Cas Induces Bone Invasion by Oral Squamous Cell Carcinoma by Regulating Tumor Epithelial-Mesenchymal Transition and Cell Proliferation Reviewed International journal

@Tatsuki Yaginuma, @Jing Gao, @Kengo Nagata, @Ryusuke Muroya, @Huang Fei, @Haruki Nagano, @Sakura Chishaki, @Takuma Matsubara, @Shoichiro Kokabu, @Kou Matsuo, @Tamotsu Kiyoshima, @Izumi Yoshioka, @Eijiro Jimi

Carcinogenesis 2020.7

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DOI： 10.1093/carcin/bgaa007.
MEST Regulates the Stemness of Human Periodontal Ligament Stem Cells Reviewed International journal

@Daigaku Hasegawa, @Kana Hasegawa, #Hiroshi Kaneko, @Shinichiro Yoshida, @Hiromi Mitarai, #Mai Arima, @Atsushi Tomokiyo, @Sayuri Hamano, @Hideki Sugii, @Naohisa Wada, @Tamotsu Kiyoshima, @Hidefumi Maeda

Stem Cells Int 2020 2020.7

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DOI： 10.1155/2020/9672673
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria Reviewed International journal

#Mizuki Sakamoto, @Masafumi Moriyama, @Mayumi Shimizu, @Akira Chinju, #Keita Mochizuki, #Ryusuke Munemura, #Keiko Ohyama , @Takashi Maehara, @Kenichi Ogata, @Miho Ohta, Masaki Yamauchi, #Noriko Ishiguro, @Mayu Matsumura, @Yukiko Ohyama, @Tamotsu Kiyoshima, @Seiji Nakamura

Mod Rheumatol 30 ( 2 ) 379 - 384 2020.3

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DOI： 10.1080/14397595.2019.1576271
Cytokeratin 19 as a biomarker of highly invasive oral squamous cell carcinoma with metastatic potential Reviewed International journal

#Tanaka S, @Kawanoa S, #Hattori T, @Matsubara R, @Sakamoto T, #Hashiguchi Y, @Kanekoa N, #Mikami Y, #Morioka N, @Maruse Y, @Kitamura R, #Hamada E, #Hiwatashi M, @Oobu K, @Kiyoshima T, @Nakamura S.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 32 ( 1 ) 1 - 7 2020.1

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DOI： 10.1016/j.ajoms.2019.10.007
Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-Like Receptor 7/Interleukin-33 Signaling Invited Reviewed International journal

ARTHRITIS & RHEUMATOLOGY 72 ( 1 ) 166 - 178 2020.1

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DOI： 10.1002/art.41052
Celecoxib suppresses lipopolysaccharide-stimulated oral squamous cell carcinoma proliferation in vitro and in vivo. Reviewed International journal

@Hisato Yoshida, @Hitoshi Yoshimura, @Shinpei Matsuda, @Satoshi Yamamoto, @Masahiro Ohmori, @Minekatsu Taga, @Keiichi Ohta, @Takashi Ryoke, @Hayato Itoi, @Tamotsu Kiyoshima, @Motohiro Kobayashi, @and Kazuo Sano

Oncology letters. 18 ( 6 ) 5793 - 5800 2019.12

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DOI： 10.3892/ol.2019.10975.
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report. Invited Reviewed International journal

@Takashi Maehara, #Ryusuke Munemura, @Mayumi Shimizu, #Noriko Kakizoe, @Naoki Kaneko, #Yuka Murakami, @Moriyama Masafumi, @Tamotsu Kiyoshima, @Shintaro Kawano, @Seiji Nakamura

MEDICINE (BALTIMORE) 98 ( 50 ) e18300 2019.12

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DOI： 10.1097/MD.0000000000018300.
CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production Reviewed International journal

#A. S. M. Rafiul Haque, @Masafumi Moriyama, @Keigo Kubota, #Noriko Ishiguro, @Mizuki Sakamoto, #Akira Chinju, #Keita Mochizuki, @Taiki Sakamoto, @Naoki Kaneko, #Ryusuke Munemura, @Takashi Maehara, @Akihiko Tanaka, @Jun-Nosuke Hayashida, @Shintaro Kawano, @Tamotsu Kiyoshima, @Seiji Nakamura

Scientific Reports. 9 2019.10

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DOI： 10.1038/s41598-019-51149-1
Osteoid osteoma of mandibular bone: Case report and review of the literature Reviewed International journal

@Maehara T., #Murakami Y., @Kawano S., #Mikami Y., @Kiyoshima T., @Chikui T., #Kakizoe N., #Munemura R., @Nakamura S.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 31 ( 322-326 ) 322 - 326 2019.9

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DOI： 10.1016/j.ajoms.2019.04.002
Ossifying fibroma in the mandibular angle mimicking metastatic clear cell renal cell carcinoma: A case report. Reviewed International journal

@Shinpei Matsuda, @Hitoshi Yoshimura, @Hisato Yoshida, @Minekatsu Taga, @Yoshiaki Imamura, @Tamotsu Kiyoshima, @Kazuo Sano

Medicine (Baltimore). 98 ( 33 ) e16595 2019.8

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DOI： 10.1097/MD.0000000000016595.
The therapeutic potential of epigallocatechin‑3‑gallate against human oral squamous cell carcinoma through inhibition of cell proliferation and induction of apoptosis: In vitro and in vivo murine xenograft study. Reviewed International journal

2019.6

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Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the oral region. Despite current therapeutic strategies, the survival rate has not been improved for several decades. Thus, it is important to develop a novel approach for the treatment of OSCC. Epigallocatechin‑3‑gallate (EGCG) is a major constituent of green tea and has previously been demonstrated to inhibit the growth of several types of cancer cells. However, few studies have investigated the effect of EGCG on human OSCC cells, especially in experimental animal models. The aim of the present study was to evaluate the therapeutic potential of EGCG for targeting human OSCC in vitro and in vivo. In the in vitro experiments, EGCG suppressed HSC‑3 cell viability in a time‑ and dose‑dependent manner. Cell cycle analysis revealed that EGCG induced G1 phase arrest of the tumor cells. Apoptosis was examined by Annexin V and propidium iodide staining, assays of caspase‑3 and -7 activity and TdT‑mediated dUTP nick end labeling (TUNEL) staining. Treatment with EGCG significantly increased caspase‑3 and -7 activities, and the percentage of apoptotic cells when compared with control cells. In the in vivo xenograft experiment on mice, EGCG treatment resulted in a 45.2% reduction in tumor size as compared with the control group without weight loss. In vivo cell proliferation and apoptosis were assessed by immunohistochemical Ki‑67 staining and the TUNEL staining. There were significant differences in Ki‑67 expression between the EGCG treatment group and control group, and the percentage of apoptotic cells in the EGCG treatment group was significantly greater than that in the control group. These results indicated that EGCG significantly inhibited cell proliferation by affecting the cell cycle progression and apoptosis in vitro and in vivo. These findings suggest that EGCG may have clinical applications as a novel approach to oral‑cancer therapy.

DOI： 10.3892/mmr.2019.10331
Impaired Junctions and Invaded Macrophages in Oral Epithelia With Oral Pain. Reviewed International journal

#Reiko U. Yoshimoto, @Reona Aijima, @Yukiko Ohyama, @Junko Yoshizumi, @Tomoko Kitsuki, @Yasuyoshi Ohsaki, #Ai-Lin Cao, @Atsushi Danjo, @Yoshio Yamashita, @Tamotsu Kiyoshima, @Mizuho A. Kido

Journal of Histochemistry & Cytochemistry 67 ( 4 ) 245 - 256 2019.4

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DOI： 10.1369/0022155418812405
A rare case of cemento-osseous dysplasia arising from a dislocated impacted tooth in the maxillary sinus. Reviewed International journal

@Junko Yoshizumi, @Hiroko Wada, @Mayumi Shimizu, @Yasufumi Horinouchi, @Tamotsu Kiyoshima, @Tetsuro Ikebe, @Akimitsu Hirakia

Journal of Oral and Maxillofacial Surgery, Medicine and Pathology 31 ( 2 ) 94 - 97 2019.3

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DOI： 10.1016/j.ajoms.2018.08.002
Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2 Reviewed International journal

233 ( 10 ) 6565 - 6577 2018.10

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We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs responsible for ΔNp63β-mediated EMT, miRNA microarray analyses were performed by ΔNp63β-overexpression in OSCC cells; SQUU-B, which lacks ΔNp63 expression and displays EMT phenotypes. miRNAs microarray analyses revealed miR-205 was the most up-regulated following ΔNp63β-overexpression. In OSCC cells, miR-205 expression was positively associated with ΔNp63 and negatively with zinc-finger E-box binding homeobox (ZEB) 1 and ZEB2, potential targets of miR-205. miR-205 overexpression by miR-205 mimic transfection into SQUU-B cells led to decreasing ZEB1, ZEB2, and mesenchymal markers, increasing epithelial markers, and reducing cell motilities, suggesting inhibition of EMT phenotype. Interestingly, the results opposite to this phenomenon were obtained by transfection of miR-205 inhibitor into OSCC cells, which express ΔNp63 and miR-205. Furthermore, target protector analyses revealed direct regulation by miR-205 of ZEB1 and ZEB2 expression. These results showed tumor-suppressive roles of ΔNp63β and miR-205 by inhibiting EMT thorough modulating ZEB1 and ZEB2 expression in OSCC.

DOI： 10.1002/jcp.26267
Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma Reviewed

@Y. Maruse, @Shintarou Kawano, @Teppei Jinno, @Ryota Matsubara, @Y. Goto, @N. Kaneko, @T. Sakamoto, @Y. Hashiguchi, @M. Moriyama, @T. Toyoshima, @R. Kitamura, @H. Tanaka, @K. Oobu, @T. Kiyoshima, @S. Nakamura

International Journal of Oral and Maxillofacial Surgery 47 ( 7 ) 836 - 845 2018.7

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DOI： 10.1016/j.ijom.2018.01.004
Effects of peritumoral bevacizumab injection against oral squamous cell carcinoma in a nude mouse xenograft model A preliminary study Reviewed

@Hisato Yoshida, @Hitoshi Yoshimura, @Shinpei Matsuda, @Takashi Ryoke, @Tamotsu Kiyoshima, @Motohiro Kobayashi, @Kazuo Sano

Oncology Letters 15 ( 6 ) 8627 - 8634 2018.6

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DOI： 10.3892/ol.2018.8399
Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1 Reviewed

Yumiko I. Matsuishi, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Hiroko Wada, Tamotsu Kiyoshima, Kazuaki Nonaka

Biochemical and Biophysical Research Communications 495 ( 2 ) 1655 - 1660 2018.1

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DOI： 10.1016/j.bbrc.2017.12.026
Oral methotrexate-related lymphoproliferative disease presenting with severe osteonecrosis of the Jaw A case report and literature review Reviewed

Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintarou Kawano, Saori Sako, Jun Nosuke Hayashida, Ryota Matsubara, Ken Ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura

Internal Medicine 57 ( 4 ) 575 - 581 2018.1

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DOI： 10.2169/internalmedicine.8946-17
Regulation of β-catenin phosphorylation by PR55β in adenoid cystic carcinoma Reviewed

15 ( 1 ) 53 - 60 2018.1

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Background/Aim: Adenoid cystic carcinoma (AdCC) is a rare cancer of the salivary gland with high risk of recurrence and metastasis. Wnt signalling is critical for determining tumor grade in AdCC, as it regulates invasion and migration. β-catenin dephosphorylation plays an important role in the Wnt pathway, but its underlying molecular mechanism remains unclear. Materials and Methods: Because the regulatory subunits of protein phosphatase 2A (PP2A) drive Wnt signalling via target molecules, including β-catenin, we used qRT-PCR and immunoblot analysis to investigate the expression of these subunits in an AdCC cell line (ACCS) and a more aggressive subline (ACCS-M). Results: PR55β was highly expressed in ACCS-M, suggesting its functional importance. In addition, PR55β expression was associated with tumor grade, with ACCS-M exhibiting higher PR55β levels. More importantly, knockdown of PR55β in ACCS-M cells significantly reduced invasiveness and metastatic ability. Furthermore, dephosphorylation and total levels of β-catenin were dependent on PR55β in ACCS-M. Finally, we confirmed a correlation between PR55β staining intensity and histopathological type in human AdCC tissues. Conclusion: Our study provides new insight into the interaction between PR55β and β-catenin and suggests that PR55β may be a target for the clinical treatment of AdCC.

DOI： 10.21873/cgp.20064
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo. Reviewed International journal

@Takashi Maehara, @Hamid Mattoo, @Vinay S Mahajan, @Samuel JH Murphy, @Grace J Yuen, #Noriko Ishiguro, @Miho Ohta, @Masafumi Moriyama, @Takako Saeki, @Hidetaka Yamamoto, @Masaki Yamauchi, @Joe Daccache, @Tamotsu Kiyoshima, @Seiji Nakamura, @John H Stone, @Shiv Pillai

Life science alliance. 1 ( 1 ) 2018.1

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DOI： 10.26508/lsa.201800050
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma Reviewed

75 148 - 157 2017.12

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We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells. By ΔNp63 knockdown, KLK6 and PAR2 expression was decreased and PAR1 was increased. Furthermore, KLK6 knockdown led to enhancing migration and invasion, and inhibiting proliferation, suggesting EMT-phenotypes. Although, in the KLK6 or PAR2 knockdown cells, phosphorylation of ERK was reduced, it was restored in the KLK6 knockdown OSCC cells treated with recombinant KLK6 proteins. Immunohistochemistry showed ΔNp63, KLK6, and PAR2 were more strongly expressed in the epithelial dysplasia and central region of OSCC than normal oral epithelium, whereas PAR1 expression was undetectable. Interestingly, at the invasive front of OSCC, ΔNp63, KLK6, and PAR2 were reduced, but PAR1 was elevated. In addition, the OSCC patients with decreasing KLK6 expression at the invasive front had more unfavourable prognosis. These results suggested differential roles of KLK6 in malignant transformation and EMT; high ΔNp63β expression up-regulates KLK6-PAR2 and down-regulates PAR1, inducing malignant transformation in oral epithelium with stimulating proliferation through ERK signal activation. Moreover, KLK6-PAR2 expression is down-regulated and PAR1 is up-regulated when ΔNp63β expression is decreased, leading to EMT with enhancing migration and invasion through ERK signal reduction at the invasive front.

DOI： 10.1016/j.oraloncology.2017.11.004
Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. Reviewed International journal

69 15 - 25 2017.6

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OBJECTIVES: We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype.
MATERIALS AND METHODS:
Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2.
RESULTS:
Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis.
CONCLUSION:
Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following ΔNp63β-mediated EMT.

DOI： 10.1016/j.oraloncology.2017.03.019
CD163(+) CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma Reviewed International journal

Keigo Kubota, Masafumi Moriyama, Sachiko Furukawa, HASM Rafiul, Yasuyuki Maruse, Teppei Jinno, Akihiko Tanaka, Miho Ohta, Noriko Ishiguro, Masaki Yamauchi, Mizuki Sakamoto, Takashi Maehara, Hayashida Jun-Nosuke, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura

SCIENTIFIC REPORTS 7 ( 1 ) 1755 2017.5

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DOI： 10.1038/s41598-017-01661-z
A case of inversely fused tooth of impacted maxillary third molar and supernumerary tooth Reviewed International journal

Eiji Mitate, Shintaro Kawano, Yurie Mikami, Tamotsu Kiyoshima, Tetsuro Ikebe, Seiji Nakamura

International Journal of Case Reports and Images 8 ( 2 ) 129 - 132 2017.3

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DOI： 10.5348/ijcri-201723-CR-10762
舌下腺に生じた多形腺腫の1例と文献的考察 Reviewed

金子　直樹, 松原良太, 川野真太郎, 見立英史, 神野哲平, 丸瀬靖之, 坂本泰基, 橋口有真, 清島保, 中村誠司

日本口腔内科学会雑誌 22 79 - 83 2016.12

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巨舌を呈した舌対称性脂肪腫症の1例 Reviewed

川野真太郎, 清島保, 三上　友理恵, 後藤　雄一, 河津俊幸, 池邉　哲郎, 中村誠司

日本口腔腫瘍学会誌 28 ( 4 ) 293 - 298 2016.10

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舌対称性脂肪腫症（SLT）は，成熟した脂肪組織が両側の舌筋内へ浸潤性増殖する疾患と定義される。今回われわれは，巨舌を呈したSLTの症例を経験したので，文献的考察を加えて報告する。
患者は，両側舌縁部に無痛性で弾性軟，多発性の腫瘤を認めた71歳の男性である。舌縁部の外向性腫瘤により，患者の舌幅は下顎の歯列弓幅よりも広く，いわゆる巨舌を呈していた。両側舌縁部の腫瘤は，MRIのT1および T2強調画像で高信号，T2脂肪抑制像で信号低下を示した。生検組織の病理組織学的診断は脂肪腫であった。病変が対称性はないものの，両側の舌縁部にあることから，SLTと診断した。慢性心房細動に対して抗凝固薬を内服しており，術後の出血および腫脹による気道閉塞が懸念されたため，左右2回に分けて全身麻酔下に腫瘍減量術を行った。切除物の病理組織検査では，成熟した脂肪組織が舌筋組織内へ浸潤性増殖している所見がみられ，病理組織学的診断はSLTであった。術後2年経過したが，増大所見は認めない。

DOI： http://doi.org/10.5843/jsot.28.293
The diagnostic utility of labial salivary gland biopsy in IgG4-related disease. Reviewed International journal

Masafumi Moriyama, Miho Ohta, Sachiko Furukawa, Yurie Mikami, Akihiko Tanaka, Takashi Maehara, Masaki Yamauchi, Noriko Ishiguro, Jun-Nosuke Hayashida, Shintaro Kawano, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura

Mod Rheumatol. 26 ( 5 ) 725 - 729 2016.9

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DOI： 10.3109/14397595.2016.1148225.
Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma Reviewed International journal

Shintaro Kawano, Y Zeng, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Toru Chikui, Tadamasa Yoshitake, Tamotsu Kiyoshima, Teppei Jinno, Yasuyuki Maruse, Eiji Mitate, Ryoji Kitamura, Hideaki Tanaka, Takeshi Toyoshima, Tsuyoshi Sugiura, Seiji Nakamura

Oncol Lett. 11 ( 5 ) 3369 - 3376 2016.5

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DOI： 10.3892/ol.2016.4411
1歳男児の下顎骨に生じたLangerhans’ cell histiocytosisの1例 Reviewed

吉住　潤子, 熊丸渉, 窪田　泰孝, 矢内理沙, 清島保, 森悦秀

日本口腔外科学会雑誌 62 ( 5 ) 18 - 23 2016.5

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Langerhans’-cell histiocytosis (LCH) is a relatively rare proliferative disorder of Langerhans’ cells with unknown etiology 1～3）. LCH can occur throughout the body, and cases have been reported in the skin, liver, spleen, lung, lymph nodes, and bone. We present a case of LCH in a 1-year-old boy who presented with fever and swelling of the right cheek. Radiographic examinations revealed expansion of the mandibular molar region with destruction of the cortex. Because such findings might mimic a malignant tumor, we made a clinical diagnosis of mandibular tumor. After confirming the pathological diagnosis, chemotherapy was performed according to the protocol of the Japan LCH study group. No recurrence was noted during a 3-year follow-up period. However, in infants, hypoplasia of the teeth can occur as a side effect of chemotherapy or a direct effect of the tumor itself. Long-term follow-up in cooperation with pediatricians and pedodontists is recommended for infants with LCH.

DOI： http://doi.org/10.5794/jjoms.62.238
顎口腔領域への転移性腫瘍についての臨床的検討 Reviewed

矢内雄太, 大山順子, 窪田泰孝, 杉浦剛, 清島保, 白砂　兼光

日本口腔外科学会雑誌６２ ( 4 ) 199 - 204 2016.4

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顎口腔領域への転移性腫瘍についての臨床的検討 Reviewed

矢内雄太, 大山順子, 窪田　泰孝, 杉浦　剛, 清島保, 白砂兼光

日本口腔外科学会雑誌 62 ( 4 ) 199 - 204 2016.4

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Metastatic tumors to the jaws and oral cavity account for 1% to 2% of all oral cancers. We report the clinical characteristics of the tumors in 11 patients among a total of 697 cases of oral cancer treated in the Section of Oral and Maxillofacial Surgery, Kyushu University Hospital from 1985 through 2010. At the first visit, 9 of the 11 patients had a history of primary tumor, while the primary cancer sites were uncertain in the other 2 patients. Six of the 9 patients had recurrence or metastasis of their primary tumors, and in the other 3 patients tumor spread was controlled. The tumor was detected in mandibular and maxillary bones in 9 patients and 2 patients, respectively. Ten of the 11 patients had metastases in the molar region. Five of the 8 patients with mandibular molar metastasis had symptoms of hypoesthesia in the lower lips and chin. Seven of the 11 cases were adenocarcinoma. Regardless of treatment such as surgical resection, radiotherapy, or chemotherapy, alone or combined, all patients had poor outcomes, and the average survival time from the first visit was 3.2 months.

DOI： http://doi.org/10.5794/jjoms.62.199
DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins. Reviewed International journal

Miho Ohta, Masafumi Moriyama, Takashi Maehara, Yuka Gion, Sachiko Furukawa, Akihiko Tanaka, Hayashida Jun-Nosuke, Masaki Yamauchi, Noriko Ishiguro, Yurie Mikami, Hiroto Tsuboi, Mana Iizuka-Koga, Shintaro Kawano, Yasuharu Sato, Tamotsu Kiyoshima, Takayuki Sumida, Seiji Nakamura

Medicine (Baltimore) 95 ( 7 ) e2853 2016.2

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DOI： doi: 10.1097/MD.0000000000002853.
Expression of SOX2, KLF4, and Brachyury transcription factor is correlated with metastasis and poor prognosis in oral squamous cell carcinoma patients. Reviewed International journal

Rumi Yoshihama, Koujiro Yamaguchi, Tsuyoshi Sugiura, Ikumi Imajyo, Mariko Mine, Naomi Hiyake, Naonari Akimoto, Yosuke Kobayashi, Satomi Chigita, Kumamaru Wataru, Tamotsu Kiyoshima, Yoshihide Mori

Oncol Lett. 11 ( 2 ) 1435 - 1446 2016.2

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舌粘膜疹と皮疹を認めた第2期梅毒の1例 Reviewed

金子　直樹, 川野真太郎, 松原良太, 笹栗　正明, 丸瀬靖之, 三上　友理恵, 清島保, 森山雅文, 中村誠司

日本口腔内科学会雑誌 2015.12

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Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation Reviewed International journal

Yasuyuki Maruse, Shintaro Kawano, Tamotsu Kiyoshima, Yuichi Goto, Ryota Matsubara, Toru Chikui, Daigo Yoshiga, Seiji Nakamura

Head Neck. 37 ( 11 ) E161 - E164 2015.11

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DOI： 10.1002/hed.24036
Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease Reviewed International journal

Kenji Ueki, Yuta Matsukuma, Masutani K, Akihiko Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Kitazono T, Kazuhiko Tsuruya

BMC NEPHROLOGY 16 2015.10

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DOI： 10.1186/s12882-015-0164-8
Complete resolution of a calcifying cystic odontogenic tumor with physiological eruption of a dislocated permanent tooth after marsupialization in a child with a mixed dentition: a case report Invited Reviewed International journal

KEIJI MASUDA, Shintaro Kawano, Haruyoshi Yamaza, Taiki Sakamoto, Tamotsu Kiyoshima, Seiji Nakamura, Kazuaki Nonaka

WORLD JOURNAL OF SURGICAL ONCOLOGY 13 2015.9

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DOI： 10.1186/s12957-015-0697-0
A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Reviewed International journal

Yoshikazu Hayashi, Masafumi Moriyama, Takashi Maehara, Yuichi Goto, Shintaro Kawano, Miho Ohta, Akihiko Tanaka, Shoko Furukawa, Hayashida Jun-Nosuke, Tamotsu Kiyoshima, Mayumi Shimizu, Toru Chikui, Seiji Nakamura

World J Surg Oncol. 13 ( 225 ) 2015.7

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DOI： doi: 10.1186/s12957-015-0644-0.
Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma. Reviewed International journal

Teppei Jinno, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Takeshi Toyoshima, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

Oncol Rep. 33 ( 5 ) 2161 - 2168 2015.5

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DOI： doi: 10.3892/or.2015.3838.
Cytokine profiles contribute to understanding the pathogenic difference between good syndrome and oral lichen planus: two case reports and literature review. Reviewed International journal

Takashi Maehara, Masafumi Moriyama, Shintaro Kawano, Hayashida Jun-Nosuke, Shoko Furukawa, Miho Ohta, Akihiko Tanaka, Masaki Yamauchi, YUKIKO OHYAMA, Tamotsu Kiyoshima, Seiji Nakamura

Medicine (Baltimore) 94 ( 14 ) e704 2015.4

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DOI： doi: 10.1097/MD.0000000000000704.
Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis. Reviewed International journal

21 ( 2 ) 257 - 262 2015.3

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DOI： 10.1111/odi.12259.
A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. Reviewed International journal

Miho Ohta, Masafumi Moriyama, Yuichi Goto, Shintaro Kawano, Akihiko Tanaka, Takashi Maehara, Shoko Furukawa, Hayashida Jun-Nosuke, Tamotsu Kiyoshima, Mayumi Shimizu, Yojiro Arinobu, Seiji Nakamura

World J Surg Oncol. 13 67 2015.2

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DOI： doi: 10.1186/s12957-015-0459-z.
The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Reviewed International journal

Masafumi Moriyama, Shoko Furukawa, Shintaro Kawano, Yuichi Goto, Tamotsu Kiyoshima, Akihiko Tanaka, Takashi Maehara, Hayashida Jun-Nosuke, Miho Ohta, Seiji Nakamura

Int J Oral Maxillofac Surg. 43 ( 10 ) 1276 - 1281 2014.10

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DOI： doi: 10.1016/j.ijom.2014.06.014.
頸部再発に対し放射線併用超選択的動注化学療法が奏功した舌扁平上皮癌の１例. Reviewed

松原良太, 川野真太郎, 清島保, 神野哲平, 丸瀬靖之, 中村誠司

日本口腔外科学会雑誌 60 ( 2 ) 76 - 81 2014.2

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Metastatic adenocarcinoma of the mandibular condyle from uterine cervix: Report of a case. Reviewed International journal

Goro Sugiyama, YUKIKO OHYAMA, MASANORI SASAKI, Tamotsu Kiyoshima, Mayumi Shimizu, Kaneki Eisuke, Yasuharu TAKENOSHITA

Oral Sci Int. 11 ( 1 ) 40 - 44 2014.1

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Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma Reviewed International journal

Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura

WORLD JOURNAL OF SURGICAL ONCOLOGY 11 2013.9

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DOI： 10.1186/1477-7819-11-234
肝性胸水発症後に多発性の肝偽小葉壊死を来した肝硬変の1剖検例 Reviewed

道免和文, 稲富裕佑, 田中博文, 春野政虎, 藤原弘明, 大野純, 清島保, 和田裕子, 下田慎治, 坂井英隆

肝臓 54 ( 4 ) 277 - 283 2013.5

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Traumatic ciliated cyst derived from zygomaticomaxillary fracture: Report of a case Reviewed International journal

Toyoshima Takeshi, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Yuji SHIRATSUCHI, Seiji Nakamura

J. Oral Maxillofac. Surg. Med. Pathol. 2013.3

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DOI： doi.org/10.1016/j.ajoms.2013.01.004
Parotid gland myoepithelioma with remarkable cystic formation: A case report Reviewed International journal

Hiroe Kakehashi, Shintaro Kawano, Tamotsu Kiyoshima, Mayumi Shimizu, Masafumi Moriyama, Ryota Matsubara, Takahiro Kiyosue, Yuichi Goto, Hideki Shiratsuchi, Seiji Nakamura

Journal of Oral and Maxillofacial Surgery, Medicine and Pathology 2012.7

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下顎歯肉に見られた腺扁平上皮癌の１例 Reviewed

見立英史, 大部一成, 吉賀大午, 川野真太郎, 河津俊幸, 清島保, 豊嶋健史, 北村亮二, 中村誠司

日本口腔腫瘍学会誌 24 ( 2 ) 55 - 61 2012.6

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原発性肝扁平上皮癌の1剖検例 Reviewed

道免和文, 田中博文, 春野政虎, 藤原弘明, 小林家吉, 清島保, 下田慎治, 坂井英隆

肝臓 53 ( 3 ) 183 - 190 2012.4

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舌下腺に発生した多形腺腫の１例 Reviewed

川野真太郎、鈴木華子、松原良太、清末崇裕、清島　保、中村誠司

日本口腔外科学会雑誌 57 ( 6 ) 2011.6

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左側上顎に発生した石灰化嚢胞性歯原性腫瘍の1例 Reviewed

藤原弘明、小林家吉、清島保、永田健吾、和田裕子、大隈由紀子、塩塚真帆、木原槇子、坂井英隆

診断病理 2011.5

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In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar. Reviewed International journal

Honda JY, Kobayashi I, Kiyoshima T, Nagata K, Wada H, Ookuma Y, Fujiwara H, Shiotsuka M, Takahashi I, Sakai H.

J Mol Histol. 2011.2

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In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar. Reviewed International journal

Akhter M, Kobayashi I, Kiyoshima T, Nagata K, Wada H, Ookuma Y, Fujiwara H, Honda JY, Sakai H.

J Mol Histol. 2010.10

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In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molar. Reviewed International journal

Xie M., Kobayashi I., Kiyoshima T., Nagata K., Ookuma Y., Fujiwara H. and Sakai H.

J Mol Histol. 2009.12

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Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar. Reviewed International journal

Honda JY, Kobayashi I, Kiyoshima T, Yamaza H, Xie M, Takahashi K, Enoki N, Nagata K, Nakashima A, Sakai H.

J Mol Histol. 2008.4

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Functional implication of nucleolin in the mouse first molar development. Reviewed International journal

Xie M, Kobayashi I, Kiyoshima T, Yamaza H, Honda JY, Takahashi K, Enoki N, Akamine A, Sakai H.

J Biol Chem. 2007.8

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Age-dependent changes in cell proliferation and cell death in the periodontal tissue and the submandibular gland in mice: a comparison with other tissues and organs. Reviewed International journal

Enoki N, Kiyoshima T, Sakai T, Kobayashi I, Takahashi K, Terada Y, Sakai H.

J Mol Histol. 2007.8

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Type II/III Runx2/Cbfa1 is required for tooth germ development Reviewed International journal

Ieyoshi Kobayashi, Tamotsu Kiyoshima, Hiroko Wada, Kou Matsuo, Kazuaki Nonaka, Jun-ya Honda, Kiyoshi Koyano, Hidetaka Sakai

Bone 2006.6

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唾液腺腫瘍151例の臨床統計的検討 Reviewed

川野真太郎、大部一成、松永和秀、川野英子、見立英史、鈴木華子、小林家吉、清島保、中村誠司

日本口腔外科学雑誌 2006.1

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Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar. Reviewed International journal

Merina Akhter, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kou Matsuo, Haruyoshi Yamaza, Hiroko Wada, Jun-ya Honda, Xie Ming, Hidetaka Sakai

Histochem. Cell Biol. 124 ( 3-4 ) 207 - 213 2005.1

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DOI： 10.1007/s00418-005-0040-x
Tissue- and bone cell-specific expression of bone sialoprotein is directed by a 9.0 kb promoter in transgenic mice. Reviewed International journal

Paz J, Wade K, Kiyoshima T, Sodek J, Tang J, Tu Q, Yamauchi M, Chen J.

Matrix Biol. 2005.1

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頭頸部領域の腺様嚢胞癌における腫瘍進展範囲−CT所見と病理組織学的所見との関係 Reviewed

杉浦一考、中山英二、石橋浩晃、吉川博政、清島保、神田重信、大石正道、白砂兼光

日本口腔腫瘍学会誌 2004.1

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Expression Pattern of Epstein-Barr Virus Latent Genes in Cell Lines Derived fromOral Squamous Cell Carcinoma. Reviewed International journal

Abu Mohammad Eahsan Rasul, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kou Matsuo, Masamichi Ohishi, Hidetaka Sakai

Oral Med. Pathol 2004.1

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The role of macrophages in the absorption process of suture materials: A histological and immunohistochemical study. Reviewed International journal

Manato JA., Kiyoshima T., Kobayashi I., Shima K., Ohishi M. and Sakai H.

Acta Histochemica et Cytochemica 31 ( 2 ) 113 - 120 1998.3

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The role of macrophages in the absorption process of suture materials: A histological and immunohistochemical study.
A fluid-phase endocytotic capacity and intracellular degradation of a foreign protein (horseradish peroxidase) by lysosomal cysteine proteinases in the rat junctional epithelium Reviewed International journal

Takayoshi Yamaza, Mizuho A Kido, Tamotsu Kiyoshima, Yukio Nishimura, Masaru Himeno, Teruo Tanaka

JOURNAL OF PERIODONTAL RESEARCH 32 ( 8 ) 651 - 660 1997.11

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DOI： DOI: 10.1111/j.1600-0765.1997.tb00575.x
An ultrastructural study of the relationship between sensory trigeminal nerves and odontoblasts in rat dentin pulp as demonstrated by the anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) Reviewed International journal

Teiichi Ibuki, Mizuho A Kido, Tamotsu Kiyoshima, Yoshihiro TERADA, Teruo Tanaka

JOURNAL OF DENTAL RESEARCH 75 ( 12 ) 1963 - 1970 1996.12

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Postnatal development of substance P-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactive nerve fibres in the synovial membrane of the rat temporomandibular joint Reviewed International journal

Seiji Shimizu, Mizuho A Kido, Tamotsu Kiyoshima, Teruo Tanaka

ARCHIVES OF ORAL BIOLOGY 41 ( 8-9 ) 749 - 759 1996.8

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Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats Reviewed International journal

Kenji Murai, Fumitaka Takeshita, Yasunori AYUKAWA, Tamotsu Kiyoshima, Tsuneo Suetsugu, Teruo Tanaka

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 30 ( 4 ) 523 - 533 1996.4

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Neuropeptide Y-, tyrosine hydroxylase-, vasoactive intestinal polypeptide-immunoreactive nerves in TMJ. Reviewed International journal

Mizuho A Kido, S Shimizu, Tamotsu Kiyoshima, Yoshihiro TERADA, Teruo Tanaka

JOURNAL OF DENTAL RESEARCH 75 749 1996.1

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Changes in the immunocytochemical localization of cathepsin L and type I collagen in rat osteoclasts treated with E-64 Reviewed International journal

Ryoji Moroi, Takayoshi Yamaza, Yasunori AYUKAWA, Tamotsu Kiyoshima, Yasuyoshi Ohsaki, Yukio Nishimura, Yoshihiro TERADA, Masaru Himeno, Teruo Tanaka

ACTA HISTOCHEMICA ET CYTOCHEMICA 28 ( 6 ) 523 - 531 1995.12

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AN IMMUNOHISTOCHEMICAL AND MONASTRAL BLUE-VASCULAR LABELING STUDY ON THE INVOLVEMENT OF CAPSAICIN-SENSITIVE SENSORY INNERVATION OF THE JUNCTIONAL EPITHELIUM IN NEUROGENIC PLASMA EXTRAVASATION IN THE RAT GINGIVA Reviewed International journal

Teruyoshi Kondo, Mizuho A Kido, Tamotsu Kiyoshima, Takayoshi Yamaza, Teruo Tanaka

ARCHIVES OF ORAL BIOLOGY 40 ( 10 ) 931 - 940 1995.10

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DOI： DOI: 10.1016/0003-9969(95)00060-3
A TOPOGRAPHICAL AND ULTRASTRUCTURAL-STUDY OF SENSORY TRIGEMINAL NERVE-ENDINGS IN THE RAT TEMPOROMANDIBULAR-JOINT AS DEMONSTRATED BY ANTEROGRADE TRANSPORT OF WHEAT-GERM AGGLUTININ-HORSERADISH PEROXIDASE (WGA-HRP) Reviewed International journal

Mizuho A Kido, Tamotsu Kiyoshima, teiichi ibuki, S Shimizu, Teruyoshi Kondo, Yoshihiro TERADA, Teruo Tanaka

JOURNAL OF DENTAL RESEARCH 74 ( 7 ) 1353 - 1359 1995.1

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IMMUNOCYTOCHEMICAL LOCALIZATION OF CATHEPSIN-L IN THE SYNOVIAL LINING CELLS OF THE RAT TEMPOROMANDIBULAR-JOINT Reviewed International journal

Tamotsu Kiyoshima, Mizuho A Kido, Yukio Nishimura, Masaru Himeno, Takayuki TSUKUBA, Hideo Tashiro, Kenji Yamamoto, Teruo Tanaka

ARCHIVES OF ORAL BIOLOGY 39 ( 12 ) 1049 - 1056 1994.12

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NEW HUMAN ORAL SQUAMOUS CARCINOMA CELL-LINE AND ITS TUMORIGENIC SUBLINE PRODUCING GRANULOCYTE-COLONY-STIMULATING FACTOR Reviewed International journal

Kou Matsuo, Yukiko Ishibashi, Ieyoshi Kobayashi, Satoru Ozeki, Masamichi OHISHI, T Tange, J Hirata, Tamotsu Kiyoshima, Hidetaka Sakai

JAPANESE JOURNAL OF CANCER RESEARCH 85 ( 12 ) 1257 - 1262 1994.12

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LOCALIZATION OF CATHEPSIN-B AND CATHEPSIN-D IN THE SYNOVIAL LINING CELLS OF THE NORMAL RAT TEMPOROMANDIBULAR-JOINT BY IMMUNO-LIGHT AND IMMUNO-ELECTRON MICROSCOPY Reviewed International journal

Tamotsu Kiyoshima, Mizuho A Kido, Takayuki TSUKUBA, Hidetaka Sakai, Kenji Yamamoto, Teruo Tanaka

Acta Histochem Cytochem. 27 ( 5 ) 441 - 450 1994.10

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Immunohistochemical evidence for the presence of nerve fibres with substance P- or calcitonin generated peptide-like immunoreactivity in the proliferating epithelium in the developing teeth of rats. Reviewed International journal

Emi Nagata, Teruyoshi Kondo, Tamotsu Kiyoshima, Minoru Nakata, Teruo Tanaka

Arch Oral Biol. 39 ( 3 ) 197 - 203 1994.3

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Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and -electron microscopy. Reviewed International journal

Tetsuya Goto, Tamotsu Kiyoshima, Ryoji Moroi, Takayuki TSUKUBA, Yukio Nishimura, Masaru Himeno, Kenji Yamamoto, Teruo Tanaka

Histochem. 101 ( 1 ) 33 - 40 1994.1

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Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast. Reviewed International journal

Tetsuya Goto, Takayuki TSUKUBA, Tamotsu Kiyoshima, Yukio Nishimura, Keitaro Kato, Kenji Yamamoto, Teruo Tanaka

Histochemistry 99 ( 5 ) 411 - 414 1993.5

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Immunohistochemical localization of cathepsins B and D in the synovial lining cells of the normal rat temporomandibular joint. Reviewed International journal

Tamotsu Kiyoshima, Takayuki TSUKUBA, Mizuho A Kido, Hideo Tashiro, Kenji Yamamoto, Teruo Tanaka

Arch Oral Biol. 38 ( 4 ) 357 - 359 1993.4

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DISTRIBUTION OF SUBSTANCE-P AND CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVE NERVE-FIBERS IN THE RAT TEMPOROMANDIBULAR-JOINT Reviewed International journal

Mizuho A Kido, Tamotsu Kiyoshima, Teruyoshi Kondo, Norio Ayasaka, Ryoji Moroi, Yoshihiro TERADA, Teruo Tanaka

JOURNAL OF DENTAL RESEARCH 72 ( 3 ) 592 - 598 1993.3

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Books

癌診療指針のための病理診断プラクティス　唾液腺/口腔・歯原性腫瘍

総編集：青笹克之　専門編集：長尾俊孝　専門副編集：高田隆　執筆：清島保（分担）他（ Role： Joint author）

中山書店 2019.9

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Language：Japanese Book type：Scholarly book
病理と臨床

特別編集：長塚仁豊澤悟　執筆：清島保（分担）他（ Role： Joint author）

文光堂 2018.4

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新口腔病理学　第2版

編集：下野正基　高田隆　田沼順一豊澤悟　執筆：清島保（分担）他

医歯薬出版 2018.4

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Language：Japanese Book type：Scholarly book
新口腔病理学

編集：下野正基　高田隆　執筆：坂井英隆　清島保（分担）他

医歯薬出版 2008.6

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Presentations

Arl4c is involved in tooth germ development through osteoblastic differentiation. Invited International conference

#Truong Thi Kim Thinh, @Shinsuke Fujii, @Tamotsu Kiyoshima

Kyudai Oral Bioscience & OBT Research Center 7th Joint International Symposium 2023 2024.2

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Event date： 2024.2

Language：English Presentation type：Oral presentation (general)

Country：Japan
転写因子NF-κB p65サブユニットによる上皮細胞分化と発毛制御

#高田、@川端由子、@清島保、@自見英治郎

第65回歯科基礎医学会学術大会 2023.9

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Event date： 2023.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京都千代田区 Country：Japan
歯根囊胞の病態形成に関与する歯原性上皮細胞の増殖機構の解明

#長野良子、@藤井慎介、@清島保

第65回歯科基礎医学会学術大会 2023.9

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Event date： 2023.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京都千代田区 Country：Japan
CLEAR CELL SQUAMOUS CELL CARCINOMA OF THE TONGUE EXHIBITS CHARACTERISTICS AS AN UNDIFFERENTIATED SQUAMOUS CELL CARCINOMA

@Kana Hasegawa, @Shinsuke Fujii, @Tamotsu Kiyoshima

21st International Congress of Oral Pathology and Medicine 2023.8

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Event date： 2023.8

Language：English Presentation type：Oral presentation (general)

Country：Taiwan, Province of China
WNT-YAP1-TGF-β AXIS PROMOTES TOOTH GERM DEVELOPMENT

2023.8

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Event date： 2023.8

Language：English Presentation type：Oral presentation (general)

Venue：Taipei City Country：Taiwan, Province of China
口腔扁平上皮癌におけるp63とMAPKシグナルによる低分子量Gタンパク質ARL4C の発現制御機構解明

@藤井慎介、#Dania Zuhier Ragheb Alkhatib、#Thinh Thi-Kim Truong、＠長谷川佳那、#長野良子、@清島保

第112回日本病理学会総会 2023.4

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Event date： 2023.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：下関 Country：Japan
口腔病理医として適切な医療に貢献するために Invited

@清島保

第41回日本口腔腫瘍学会総会・学術大会 2023.1

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Event date： 2023.1 - 2023.2

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：WEB開催 Country：Japan
Wnt signaling promotes tooth germ development mediated by YAP1-TGF-β signaling Invited International conference

2022.10

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Event date： 2022.10

Language：English Presentation type：Oral presentation (general)

Venue：福岡（WEB併用ハイブリッド形式） Country：Japan
RAF1–MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation Invited International conference

2022.10

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Event date： 2022.10

Language：English Presentation type：Oral presentation (general)

Venue：福岡（WEB併用ハイブリッド形式） Country：Japan
未分化な扁平上皮癌の特徴を有する舌に生じた clear cell squamous cell carcinoma

@長谷川佳那，@藤井慎介，@清島保

第32回日本口腔内科学会・第33回日本臨床口腔病理学会・第35回日本口腔診断学会合同学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：北海道札幌市 Country：Japan
唾液腺発生と腺様嚢胞癌腫瘍形成における軸索誘導因子 Semaphorin 3A (Sema3A)の役割の解明

#藤本龍史，@藤井慎介，@清島保

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：徳島県徳島市 Country：Japan
低分子量 G タンパク質 ARL4C の発現はエナメル上皮腫における腫瘍細胞増殖と破骨細胞形成を促進する

@藤井慎介，@自見英治郎，@清島保

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：徳島県徳島市 Country：Japan
口腔扁平皮癌において p63 シグナルは YAP シグナルと協調的に細胞内シグナルおよび DNA メチル化を制御する

@長谷川佳那，@藤井慎介，@清島保

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：徳島県徳島市 Country：Japan
Wnt 経路は YAP1-TGF-β 経路を介して歯胚の発生を促進する

#長野良子，@藤井慎介，@清島保

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：徳島県徳島市 Country：Japan
エナメル上皮腫における低分子量Gタンパク質ARL4Cの発現は腫瘍細胞増殖と破骨細胞形成を促進する

@藤井慎介、@自見英治郎、@清島保

第111回日本病理学会総会 2022.4

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Event date： 2022.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸 Country：Japan
口腔癌においてYAPシグナルは異型性および上皮間葉転換を誘導する

@長谷川　佳那、@藤井慎介、@清島保

第111回日本病理学会総会 2022.4

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Event date： 2022.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸 Country：Japan
YAP-PIEZO1 axis promotes cell proliferation of oral squamous cell carcinoma Invited International conference

@Kana Hasegawa, @Shinsuke Fujii, @Tamotsu Kiyoshima

Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium 2021 2021.11

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Event date： 2021.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
口腔扁平上皮癌における「腫瘍実質-間質連関」による細胞増殖制御機構の解明

@藤井慎介、@清島保

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
WntシグナルがYAPを介して歯胚の形態形成を制御する分子基盤の解明

#長野良子、＠藤井慎介、＠清島保

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を促進する

@長谷川　佳那、@藤井慎介、@清島保

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
エナメル上皮腫におけるRAF1-MAPK依存性の低分子量Gタンパク質ARL4Cの高発現は腫瘍細胞増殖と破骨細胞形成を促進する

#小倉萌、@藤井慎介、@自見英治郎、@清島保

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
軸索誘導因子Sema3Aによる唾液腺形態形成および腺様嚢胞癌の増殖制御メカニズムの解明

#藤本龍史、@藤井慎介、@清島保

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
Sema3A-AKT Axis In Salivary Gland And Adenoid Cystic Carcinoma Developments

2020.11

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Event date： 2021.6

Language：English Presentation type：Oral presentation (general)

Country：Japan
YAP-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を制御する

@藤井慎介、@長谷川　佳那、@清島保

第１１０回日本病理学会総会 2021.4

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Event date： 2021.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
口腔扁平上皮癌における増殖および分化転換の新規分子基盤の解明 Invited

@藤井慎介、@清島保

第62回歯科基礎医学会学術大会 2020.9

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Event date： 2020.9 - 2020.10

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：鹿児島 Country：Japan
軸索ガイダンス因子Sema3aによる唾液腺発生制御メカニズムの解明

#藤本龍史、@藤井慎介、@清島保

第62回歯科基礎医学会学術大会 2020.9

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Event date： 2020.9 - 2020.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島 Country：Japan
新規癌関連遺伝子のエナメル上皮腫における高発現とその機能解析

#石橋　拓馬、@藤井慎介、@清島保

第62回歯科基礎医学会学術大会 2020.9

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Event date： 2020.9 - 2020.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島 Country：Japan
ヒト口腔扁平上皮癌に高発現した機械受容器TRPV4はCaMK II/AKTシグナル伝達を介して癌細胞の増殖を制御する

#田尻　祐大、@藤井慎介、@清島保

第62回歯科基礎医学会学術大会 2020.9

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Event date： 2020.9 - 2020.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島 Country：Japan
機械受容器TRPV4はヒト口腔扁平上皮癌細胞の増殖を制御する

#田尻　祐大、@藤井慎介、@大関　悟、@清島保

第１０９回日本病理学会総会 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Hippo-PIEZO1シグナルは口腔扁平上皮癌の細胞増殖を制御する

@長谷川　佳那、@藤井　慎介、@清島　保

第１０９回日本病理学会総会 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
歯原性腫瘍におけるWntシグナルネットワークの破綻 Invited

@藤井慎介、@清島保

第１０９回日本病理学会総会 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：福岡 Country：Japan
エナメル上皮腫における新規癌関連遺伝子の発現とその機能解析

#石橋　拓馬、@藤井慎介、@設楽　沙月、@小倉萌、@清島保

第１０９回日本病理学会総会 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Wnt-Sema3aシグナルは唾液腺の発生を制御する

#藤本龍史、@藤井慎介、@清島保

第１０９回日本病理学会総会 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
A case of extramammary Paget’s disease occurring in the hard palate of patient with oral squamous cell carcinoma

第２９回日本臨床口腔病理学会/第11回日本口腔検査学会共催学術大会 2018.8

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Event date： 2019.8

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
新規癌関連遺伝子のエナメル上皮腫における発現とその機能解析-課外授業での研究活動報告-

#設楽沙月、#小倉萌、@藤井慎介、@清島保

第38回日本歯科医学教育学会総会および学術大会 2019.7

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Event date： 2019.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Wnt/β-カテニン−Sema3aシグナルは唾液腺の発生を制御する-課外授業での研究活動報告-

#藤本　龍史、@藤井慎介、@和田　尚久、@清島保

第38回日本歯科医学教育学会総会および学術大会 2019.7

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Event date： 2019.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
機械受容器TRPV4はヒト口腔癌細胞の増殖を制御する

@藤井慎介、#田尻　祐大、@大関　悟、@清島保

第１０8回日本病理学会総会 2019.5

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Event date： 2019.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
口腔扁平上皮癌の腺癌組織への転換および悪性化におけるDNAメチル化機構の解明

@三上　友理恵、@藤井　慎介、@中村誠司、@清島　保

第１０8回日本病理学会総会 2019.5

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Event date： 2019.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
ヒト口腔癌における TRPV4 の発現と機能解析

#田尻祐大， @藤井慎介， @大関悟， @清島保

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
ヒト口腔癌におけるTRPV4の発現と機能解析

#田尻祐大，　@藤井慎介，　@大関悟，　@清島保

第60回歯科基礎医学会学術大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
腺扁平上皮癌におけるエピジェネティックな変化は扁平上皮組織を腺組織に転換する

＠三上友理恵，＠藤井慎介，＠中村誠司，＠清島保

第60回歯科基礎医学会学術大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
機械感受性イオンチャネルPiezo1 の発現は口腔扁平上皮癌の細胞増殖を制御する

@長谷川佳那， @藤井慎介， @清島保

第60回歯科基礎医学会学術大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌ　study of beta-catenin expression in the salivary gland tumors

第60回歯科基礎医学会学術大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
機械感受性イオンチャネル Piezo1 の発現は口腔扁平上皮癌の細胞増殖を制御する

@長谷川佳那， @藤井慎介， @清島保

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
腺扁平上皮癌におけるエピジェネティックな変化は扁平上皮組織を腺組織に転換する

@三上友理恵， @藤井慎介， @中村誠司， @清島保

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
唾液腺腫瘍における β-カテニン発現に関する免疫組織化学的研究

#岡崎裕紀， #稲葉日和吏， @永田健吾， @藤井慎介， @清島保

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
口腔扁平上皮癌においてGLI-KRT17連関は腫瘍における増殖を抗アポトーシス作用を介して促進する

#三上友理恵、@藤井慎介、@清島保

第107回日本病理学会総会 2018.6

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
歯牙腫におけるWnt/β-cateninシグナルの活性化は軸索伸張制御因子(Sema3A)を介して増殖を制御する

@藤井慎介, @永田健吾, @清島　保, @和田尚久

第107回日本病理学会総会 2018.6

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
Expression and function of Piezo1 and Piezo2 in tooth germ development International conference

#Misaki Abe, @Hiroko Wada, @Tamotsu Kiyoshima

Kyudai Oral Bioscience 2018 2018.2

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Event date： 2018.2

Language：English Presentation type：Oral presentation (general)

Country：Japan
後発転移リンパ節に腺扁平上皮癌を認めた舌原発扁平上皮癌の 1 例

＠三上友理恵、＠大部一成、＠松原良太、＠北村亮二、＠清島保、＠川野真太郎、＠中村誠司

第36回日本口腔腫瘍学会総会・学術大会 2018.1

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Event date： 2018.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：新潟市 Country：Japan
歯牙腫におけるWnt/β-cateninシグナルの活性化は軸索伸張制御因子を介して増殖を制御する

@藤井慎介, @永田健吾, @清島　保, @和田尚久

第63回日本病理学会秋期特別総会 2017.11

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Event date： 2017.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
口腔扁平上皮癌においてGLI-KRT17連関は腫瘍細胞の増殖を促進する

@三上友理恵, @藤井慎介, @永田健吾, @和田裕子, @長谷川佳那, #安部みさき, #吉本怜子, @中村誠司, @清島保

第59回歯科基礎医学会大会 2017.9

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Event date： 2017.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：松本 Country：Japan
A case of Plasmablastic lymphoma arising in oral cavity and extraoral site

Hiroko Wada, Koki Nagano, Yurie Mikami, Misaki Abe, Tomohiro Yamada, Yoshihide Mori and Tamotsu Kiyoshima

2017.8

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Event date： 2017.8

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
The expression pattern of the FRG1 in the mouse developing tooth germ. International conference

Hiroko Wada, Kana Hasegawa, Kengo Nagata, Naohisa Wada, Yurie Mikami, Hidetaka Sakai, Tamotsu Kiyoshima

The 95th General Session & Exhibition of the IADR 2017.3

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Event date： 2017.3

Language：English Presentation type：Oral presentation (general)

Country：United States
GLI-KRT17連関は口腔扁平上皮癌における腫瘍形成を促進する

三上　友理恵, 清島保

第93回九大病理研究会 2016.12

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Event date： 2016.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
温度感受性イオンチャネルによる口腔上皮細胞の細胞間接着制御

吉本　玲子, 合島怜央奈, 大﨑康吉, 張旌旗, 清島保, 西村英紀, 城戸瑞穂

平成28年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会 2016.11

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Event date： 2016.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
口腔扁平上皮癌における免疫回避機構と腫瘍随伴性マクロファージとの関連

久保田　恵吾, 森山雅文, 古川　祥子, Rafiul Haque A.S.M., 丸瀬　靖之, 石黒乃理子, 坂本瑞樹, 川野真太郎, 林田淳之介, 太田　美穂, 清島保, 中村誠司

第44回日本臨床免疫学会総会 2016.9

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Event date： 2016.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
口腔扁平上皮癌においてGli阻害剤(GANT61)は細胞死を誘導する

三上　友理恵, 永田健吾, 和田裕子, 藤井慎介, 安部　みさき, 吉本　玲子, 清島保, 中村誠司

第58回歯科基礎医学会学術大会総会 2016.8

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Event date： 2016.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
ヒト口腔癌細胞株におけるTRPチャネルの機能解析

合島怜央奈, 吉本　玲子, 曹愛琳, 森啓輔, 張旌旗, 大﨑康吉, 壇上敦, 清島保, 城戸瑞穂

第58回歯科基礎医学会学術大会総会 2016.8

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Event date： 2016.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
TRPV4チャネルを介した温度変化による口腔上皮細胞調節

吉本　玲子, 合島怜央奈, 大﨑康吉, 曹愛琳, 張旌旗, 清島保, 城戸瑞穂

第58回歯科基礎医学会学術大会総会 2016.8

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Event date： 2016.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
Mandibular tumor International conference

Hiroko Wada, Aki Kinjo, Yurie Mikami, Tuyoshi Sugiura, Tamotsu Kiyoshima

The 27th Annual Meeting of the Japanese Society of Oral Pathology 2016.8

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Event date： 2016.8

Language：English Presentation type：Oral presentation (general)

Country：Japan
A case of adenosquamous carcinoma observed in the metastatic lymph node, but not in the primary lesion.

2016.8

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Event date： 2016.8

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Temperature changes effect on intercellular adhesion of oral epithelial cells. International conference

Reiko U. Yoshimoto, Reona Aijima, Yasuyoshi Ohsaki, Zhang J.Q., Cao A.L., Tamotsu Kiyoshima, Kido M.A.

The 15th International Symposium on Molecular and Neural Mechanism of Taste and Olfactory Perception. 2016.6

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Event date： 2016.6

Language：English Presentation type：Oral presentation (general)

Country：Japan
口腔扁平上皮癌の浸潤・転移における腫瘍随伴性マクロファージの関与

久保田　恵吾, 森山雅文, 古川　祥子, 丸瀬　靖之, Rafiul Haque A.S.M., 石黒乃理子, 坂本瑞樹, 川野真太郎, 清島保, 中村誠司

第70回日本口腔科学会学術集会 2016.4

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Event date： 2016.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
舌尖部に生じた低悪性筋線維芽細胞肉腫 (low-grade myofibroblastic sarcoma) の１例

三上　友理恵, 森山雅文, 見立英史, 家田　晋輔, 川野真太郎, 清島保, 中村誠司

第34回日本口腔腫瘍学会科学会 2016.1

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Event date： 2016.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：横浜 Country：Japan
マウス歯胚形成過程における Glucose regulated protein-78タンパクの発現について

三上　友理恵, 永田健吾, 清島保

第92回九大病理研究会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
特異なCT像を呈した下顎骨線維-骨性病変の１例

吉住　潤子, 和田　裕子, 清水真弓, 碇　竜也, 新田　秀一, 清島保, 堀之内　康文

第48回NPO法人日本口腔科学会九州地方部会 2015.11

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
舌尖部に生じた低悪性筋線維芽細胞肉腫 (low-grade myofibroblastic sarcoma) の１例

三上　友理恵, 森山雅文, 見立英史, 川野真太郎, 清島保, 中村誠司

第48回NPO法人日本口腔科学会九州地方部会 2015.11

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
長期透析患者に発症した舌アミロイドーシスの1例

碇　竜也, 堀之内　康文, 安部　みさき, 新田　秀一, 吉住　潤子, 和田裕子, 清島保, 森悦秀

第60回日本口腔外科学会総会・学術大会 2015.10

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Event date： 2015.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：名古屋 Country：Japan
リガンド依存性受容体DCC 蛋白による口腔扁平上皮癌へのアポトーシス誘導

清島保, 和田裕子

第57回歯科基礎医学会学術大会総会 2015.9

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Event date： 2015.9

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：福岡 Country：Japan
埋伏歯を含み上顎洞内に発生した限局性骨性異形成症の一例

吉住　潤子, 上里　梓, 碇　竜也, 新田　秀一, 清水真弓, 和田裕子, 清島保, 堀之内　康文

日本口腔外科学会・第83回九州支部学術集会 2015.6

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
右下顎骨腫瘍

和田裕子, 金城　亜紀, 山田　裕一, 孝橋賢一, 杉浦　剛, 小田義直, 清島保

第５４回日本骨軟部腫瘍研究会 2015.5

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Event date： 2015.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
歯胚の発生・発育におけるFacioscapulohumeral Muscular Dystrophy Region Gene 1（FRG1）の発現様式.

長谷川　佳那, 和田裕子, 清島保

第91回九大病理研究会 2014.12

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Event date： 2014.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
歯胚の発生・発育におけるFacioscapulohumeral Muscular Dystrophy Region Gene 1（FRG1）の発現様式.

長谷川　佳那, 和田裕子, 永田健吾, 藤原弘明, 染矢　祐孝, 神野　彰子, 三上　友理恵, 清島保

第56回歯科基礎医学会学術大会・総会 2014.9

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Event date： 2014.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
V-ATPase阻害剤Concanamycin A抵抗性口腔扁平上皮癌株に対するSAHA併用による細胞増殖抑制効果

清島保, 永田健吾, 和田裕子, 藤原弘明, 坂井英隆

第103回日本病理学会総会 2014.4

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Event date： 2014.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：広島 Country：Japan
非歯原性上皮細胞へのThymosin beta 4遺伝子導入による歯原性上皮細胞への誘導

藤原弘明, 清島保, 永田健吾, 和田裕子, 坂井英隆

第103回日本病理学会総会 2014.4

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Event date： 2014.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：広島 Country：Japan
Analysis of the Anti-tumor Effects of V-ATPase inhibitor, Concanamycin A1, on Oral Squamous Cell Carcinoma International conference

103rd USCAP (United States & Canadian Academy of Pathology) Annual Meeting 2014.3

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Event date： 2014.3

Language：English

Country：United States
Itm2a Expression during the Tooth Germ Development International conference

Kyudai Oral Bioscience (KOB) 2014.2

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Event date： 2014.2 - 2014.3

Language：English Presentation type：Oral presentation (general)

Country：Japan
腫瘍内埋伏歯を温存した石灰化嚢胞性歯原性腫瘍の1例

福田　直志, 熊丸渉, 窪田　泰孝, 井上美子, 清島保, 河津　俊幸, 星野　亜紀, 二宮史浩

第32回日本口腔腫瘍学会総会・学術大会 2014.1

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Event date： 2014.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
マウス歯胚形成過程におけるintegral membrane protein 2a（itm2a）の発現様式

木原槇子, 清島保, 永田健吾, 和田裕子, 藤原弘明, 長谷川佳那, 染矢祐孝, 髙橋一郎, 坂井英隆

第55回歯科基礎医学会学術大会・総会 2013.9

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Event date： 2013.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：岡山 Country：Japan
マウス歯肉上皮由来角化細胞へのThymosin beta 4遺伝子導入による歯原性上皮細胞誘導

染矢祐孝, 清島保, 永田健吾, 和田裕子, 藤原弘明, 木原槇子, 長谷川佳那, 古谷野潔, 坂井英隆

第55回歯科基礎医学会学術大会・総会 2013.9

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Event date： 2013.9

Language：Japanese

Venue：岡山 Country：Japan
Thymosin beta 4遺伝子導入による歯原性上皮細胞の作製

藤原弘明, 清島保, 永田健吾, 和田裕子, 木原槇子, 長谷川佳那, 染矢祐孝, 坂井英隆

第55回歯科基礎医学会学術大会・総会 2013.9

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Event date： 2013.9

Language：Japanese

Venue：岡山 Country：Japan
扁平上皮癌移植モデルマウスを用いたNetrin-1結合部位欠失DCC遺伝子導入の影響

和田裕子, 清島保, 藤原弘明, 坂井英隆

第24回日本臨床口腔病理学会 2013.8

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Event date： 2013.8

Language：Japanese

Venue：東京 Country：Japan
口腔扁平上皮癌細胞株間におけるV-ATPase阻害剤Concanamycin A 感受性について

清島保, 永田健吾, 和田裕子, 藤原弘明, 坂井英隆

第102回日本病理学会総会 2013.6

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Event date： 2013.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
V-ATPase阻害剤Concanamycin Aによる口腔扁平上皮の細胞死誘導について

吉田寿人, 清島保, 永田健吾, 和田裕子, 藤原弘明, 坂井英隆

第54回歯科基礎医学会学術大会・総会 2012.9

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Event date： 2012.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
マウス歯胚形成を制御するThymosin β10の発現様式解析と機能解析

塩塚真帆, 和田裕子, 清島保, 永田健吾, 藤原弘明, 髙橋一郎, 坂井英隆

第54回歯科基礎医学会学術大会・総会 2012.9

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Event date： 2012.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
エナメル上皮腫におけるThymosin β4の発現とその役割について

清島保, 永田健吾, 和田裕子, 藤原弘明, 坂井英隆

第54回歯科基礎医学会学術大会・総会 2012.9

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Event date： 2012.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
DCC蛋白細胞内ドメインによるアポトーシス誘導機構の解析

和田裕子, 清島保, 藤原弘明, 坂井英隆

第23回日本臨床口腔病理学会総会 2012.8

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Event date： 2012.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
Netrin-1結合部位欠失DCC遺伝子導入による癌細胞のアポトーシス誘導

和田裕子, 清島保, 小林家吉, 永田健吾, 藤原弘明, 塩塚　真帆, 坂井英隆

第101回日本病理学会総会 2012.4

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Event date： 2012.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
癌治療用アポトーシス誘導ベクターの作成と導入の試み

古庄　克宏、和田　裕子、清島　保、小林　家吉、永田　健吾、藤原　弘明、塩塚　真帆、坂井　英隆

第53回歯科基礎医学会学術大会ならびに総会 2011.8

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Event date： 2011.9 - 2011.10

Presentation type：Oral presentation (general)

Venue：岐阜 Country：Japan
口唇部腫瘍 Soft tissue tumour of the lower lip International conference

和田　裕子、清島　保、小林　家吉、藤原　弘明、坂井　英隆

第22回日本臨床口腔病理学会、第5回アジア口腔病理学会 2011.8

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Event date： 2011.8

Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
歯胚形成過程におけるThymosinβ-10の役割　～Thymosinβ-4との比較検討～

和田裕子、塩塚真帆、清島保、小林家吉、永田健吾、藤原弘明、坂井英隆

第100回日本病理学会総会 2011.4

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Event date： 2011.4

Presentation type：Oral presentation (general)

Venue：横浜 Country：Japan
Expression pattern and possible function of thymosin beta-10 in developing tooth germ compared with thymosin beta-4 International conference

Maho Shiotsuka, Hiroko Wada, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Kengo Nagata, Hiroaki Fujiwara, Ichiro Takahashi and Hidetaka Sakai

2011.3

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Event date： 2011.3

Presentation type：Oral presentation (general)

Country：Japan
Functional implication of thymosin beta-4 in the morphogenesis of the tooth germ via the regulation of odontogenic gene expressions International conference

Yukiko Ookuma, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Kazuaki Nonaka and Hidetaka Sakai

2011.3

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Event date： 2011.3

Presentation type：Oral presentation (general)

Country：Japan
ヒストン脱アセチル化酵素阻害剤suberoylanilide hydroxamic acidによるヒト口腔扁平上皮癌細胞のアポトーシス誘導

永田健吾、小林家吉、清島保、和田裕子、大隈由紀子、藤原弘明、坂井英隆

第52回歯科基礎医学会学術大会ならびに総会 2010.9

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Event date： 2010.9

Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
マウス歯胚形成過程におけるThymosinβ10とThymosinβ4との発現様式の比較検討

和田裕子、清島保、小林家吉、塩塚真帆、永田健吾、大隈由紀子、藤原弘明、高橋一郎、坂井英隆

第52回歯科基礎医学会学術大会ならびに総会 2010.9

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Event date： 2010.9

Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
Functional implication of Thymosin beta 4 in the tooth development International conference

Y. OOKUMA, I. KOBAYASHI, T. KIYOSHIMA, K. NAGATA, H. FUJIWARA, H. YAMAZA, K. NONAKA, and H. SAKAI

the 88th IADR/AADR 2010.7

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Event date： 2010.7

Country：Spain
Thymosin beta 4のノックッダウンによる歯原性細胞の変化について

小林家吉、清島　保、永田健吾、和田裕子、藤原弘明、坂井英隆

第100回日本病理学会総会 2011.4

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Event date： 2010.4 - 2011.4

Presentation type：Oral presentation (general)

Venue：横浜 Country：Japan
ヒト口腔扁平上皮癌細胞のヒストン脱アセチル化酵素阻害剤によるアポトーシス誘導

永田健吾、小林家吉、清島保、藤原弘明、坂井英隆

第99回日本病理学会総会 2010.4

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Event date： 2010.4

Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
IL-22によるヒト口腔扁平上皮癌の細胞形質に対する影響

清島保、小林家吉、永田健吾、藤原弘明、坂井英隆

第99回日本病理学会総会 2010.4

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Event date： 2010.4

Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
Interleukin-22-induced STAT3 signal transduction in oral squamous cell carcinoma. International conference

Lutfun Naher, Tamotsu Kiyoshima, Seiji Nakamura, Hidetaka Sakai.

2010.2

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Event date： 2010.2

Presentation type：Oral presentation (general)

Country：Japan
歯胚形成過程におけるRpl21およびIfrg15の発現様式について

小林家吉、清島　保、永田健吾、大隈由紀子、藤原弘明、坂井英隆

第51回歯科基礎医学会学術大会ならびに総会 2009.9

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Event date： 2009.9

Presentation type：Oral presentation (general)

Venue：新潟 Country：Japan
Epstein-Barr ウイルス感染による口腔扁平上皮癌細胞の生物学的特性変化について

小林家吉、清島保、永田健吾、Lutfun Naher、坂井英隆

第18回日本アポトーシス研究会 2009.8

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Event date： 2009.8

Venue：長崎 Country：Japan
IgG4関連硬化性疾患における生検小唾液腺の病理学的所見

清島保、小林家吉、藤原弘明、坂井英隆

第20回日本臨床口腔病理学会総会・学術大会 2009.7

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Event date： 2009.7

Venue：札幌 (北海道) Country：Japan
ヒト口腔上皮癌におけるIL-22シグナル伝達経路

清島保、小林家吉、坂井英隆

第98回日本病理学会総会 2009.5

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Event date： 2009.5

Venue：京都 Country：Japan
小児に発生した顎骨中心性歯原性線維腫（WHO-type）の１例

陶山曜子、窪田泰孝、二宮史浩、矢原佳枝、清島保、岡村和俊、白砂兼光,

第63回日本口腔科学会学術集会 2009.4

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Event date： 2009.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：浜松 Country：Japan
STAT3 signal transduction in squamous cell carcinoma stimulated by IL-22 International conference

L. NAHER, T. KIYOSHIMA, H. FUJIHARA, I. KOBAYASHI, K. NAGATA, K. FUKIWAKE, Y. OOKUMA, S. NAKAMURA, and H. SAKAI

the 87th IADR/AADR 2009.4

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Event date： 2009.4

Presentation type：Oral presentation (general)

Country：United States
Possible functions of Protogenin in the tooth development International conference

K. FUKIWAKE, T. KIYOSHIMA, I. KOBAYASHI, K. NAGATA, and H. SAKAI

the 86th IADR/AADR 2008.7

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Event date： 2008.7

Country：Canada
歯胚形成過程におけるNucleolinおよびThymosin beta4の関与について

小林家吉、清島保、坂井英隆

第97回日本病理学会総会 2008.5

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Event date： 2008.5

Venue：石川県金沢 Country：Japan
歯胚発生過程における膜蛋白Protogeninの発現と歯胚発育への関与

清島保、小林家吉、坂井英隆

第97回日本病理学会総会 2008.5

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Event date： 2008.5

Venue：石川県金沢 Country：Japan
Functional implication of thymosin beta 4 on the morphogenesis of tooth germ in the mouse lower first molar International conference

Yukiko Ookuma, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kenogo Nagata, Kazuaki Nonaka and Hidetaka Sakai

2009.2

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Presentation type：Oral presentation (general)

Country：Japan
Squamous cell carcinoma antigens, SCCA1 and SCCA2, inhibit TNF-alpha-induced cell death by suppression of cytochrome c release from mitochondria International conference

K. Hashimoto, T. Kiyoshima, I. Kobayashi, H. Sakai, T. Ikebe, S. Ozeki

The 47th congress of the korean association of oral & maxillofacial surgeons 2006.4

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Presentation type：Oral presentation (general)

Country：Korea, Republic of
口腔扁平上皮癌細胞株におけるS100A7遺伝子プロモーターの転写活性機構の解析

清島　保、小林家吉、坂井英隆

第95回日本病理学会総会 2006.4

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Presentation type：Oral presentation (general)

Venue：東京　新宿 Country：Japan
Transcriptional Regulation of S100A7 in Oral Squamous Cell Carcinoma International conference

Tamotsu Kiyoshima, Ieyoshi Kobayashi, Keiko Takahashi and Hidetaka Sakai

The International Association for Dental Research (84th) 2006.6

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Presentation type：Oral presentation (general)

Country：Australia

Transcriptional Regulation of S100A7 in Oral Squamous Cell Carcinoma
Differentially expressed genes detected by cDNA subtraction are implicated in mouse molar tooth germ development. Invited International conference

Tamotsu Kiyoshima

International symposium -Dental and Craniofacial Morphogenesis and Tissue Regulation- 2007.3

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Presentation type：Oral presentation (invited, special)

Country：Japan
歯胚発生に関わる新規遺伝子Clone15の機能解析

吹譯　景子、清島　保、小林家吉、榎　規雄、寺田善博、坂井　英隆

第49回歯科基礎医学会総会 2007.8

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Presentation type：Oral presentation (general)

Venue：札幌 (北海道) Country：Japan
歯胚発生過程におけるNucleolinおよびThymosin beta 4の役割について

小林家吉、清島　保、吹譯　景子、榎　規雄、永田健吾、坂井英隆

第49回歯科基礎医学会総会 2007.8

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Presentation type：Oral presentation (general)

Venue：札幌 (北海道) Country：Japan
歯胚発生過程における膜タンパクProtogeninの関与

清島　保、吹譯　景子、坂井　英隆

第84回九大病理研究会 2007.12

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Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
“Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of mouse lower first molar” International conference

清島　保、吹譯　景子、小林　家吉、永田　健吾、坂井　英隆

合同ミィーティング - 第３回 “口腔健康科学 “ シンポジウムならびに第３回 “口腔組織の再生・再建医療研究”シンポジウム 2008.1

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Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
“Roles of thymosin beta 4 and nucleolin in the developing tooth germ of the mouse lower first molar” International conference

小林　家吉、清島　保、永田　健吾、坂井　英隆

合同ミィーティング - 第３回 “口腔健康科学 “ シンポジウムならびに第３回 “口腔組織の再生・再建医療研究”シンポジウム 2008.1

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Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Interleukin-22 (IL-22) Signal Transduction in Oral Squamous Cell Carcinoma Cell line

2008.12

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Presentation type：Oral presentation (general)

Country：Japan
Distinct disease-specific Tfh cell populations in two different fibrotic diseases: IgG4-related disease and Kimura’s disease Invited International conference

2024.2

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Event date： 2024.2

Language：English Presentation type：Oral presentation (general)

Venue：福岡（WEB併用ハイブリッド形式） Country：Japan
p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands Invited International conference

@Jing Gao, #Aonan Li, @Shinsuke Fujii, #Fei Huang, @Tamotsu Kiyoshima, @Eijiro Jimi

Kyudai Oral Bioscience & OBT Research Center 7th Joint International Symposium 2023 2024.2

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Event date： 2024.2

Language：English Presentation type：Oral presentation (general)

Country：Japan
PRIPがM1 / M2マクロファージの分極化に与える影響についての検討

@佐野朋美、#Malaz Elsheikh、@溝上顕子、@清島保、@兼松隆

第65回歯科基礎医学会学術大会 2023.9

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Event date： 2023.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京都千代田区 Country：Japan
p130cas はマウス顎下腺の顆粒性導管細胞分化のための ER-ゴルジネットワークの形成に重要な役割を果たす

#李傲男，@高靖，@藤井慎介，@清島保，@自見英治郎

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：徳島県徳島市 Country：Japan
p130Cas はマウス顎下腺の顆粒性導管の発達に関与する

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川（WEB開催） Country：Japan
遠位筋優位の症状を呈したシェーグレン症候群合併免疫介在性壊死性筋症の1例

山本賢、山嵜奨、平峯智、柏戸佑介、貞島祥子、藤井慎介、松本佑慈、太田梓、髙山耕治、池崎裕昭、豊田一弘、小川栄一、村田昌之、清島保、下野信行

第23回日本病院総合診療医学会学術総会 2021.9

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Event date： 2021.9 - 2021.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台（WEB開催） Country：Japan
口腔粘膜上皮バリアと温度感受性イオンチャネルの関わり

#吉本怜子、@清島保、@城戸瑞穂

第95回九大病理研究会 2018.12

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Event date： 2018.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
口腔粘膜の創傷治癒過程における温度感受性イオンチャネルの関わり

#吉本怜子、@合島怜央奈、#曹愛琳、@大崎康吉、@張旌旗、@藤井慎介、@清島保、@西村英紀、@城戸瑞穂

第61回秋季日本歯周病学会学術大会 2018.10

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Event date： 2018.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪 Country：Japan
TRPV4 遺伝子欠失マウスにおける口腔粘膜創傷治癒の解析

#吉本怜子， @合島怜央奈， @大崎康吉， @藤井慎介， @張旌旗， #曹愛琳， #高イキ， @清島保， @城戸瑞穂

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
TRPV4遺伝子欠失マウスにおける口腔粘膜創傷治癒の解析

#吉本怜子、@合島怜央奈、@大崎康吉、@張旌旗、#曹愛琳、@高瑋琦、@清島保、@城戸瑞穂

第60回歯科基礎医学会学術大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
唾液腺の発生および機能発現における p130Cas の役割

#室屋龍佑， @高靖， @中富千尋， @藤井慎介， @清島保， @自見英治郎

第60回歯科基礎医学会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Warm-activated TRPV4 enhances oral epithelial cell-cell adhesion and suppresses migration. International conference

#Reiko U. Yoshimoto, @Reona Aijima, @Yasuyoshi Ohsaki, @Jing-Qi Zhang, @Tamotsu Kiyoshima, @Fusanori Nishimura, @Mizuho A. Kido

The 96th General Session of the International Association of Dental Research 2018.7

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Event date： 2018.7

Language：English Presentation type：Oral presentation (general)

Country：United Kingdom
新規象牙質細胞マーカーとしてのチロシン水酸化酵素の可能性

藤野翔香, 濱野さゆり, 芹田俊, 友清淳, 長谷川大学, 吉田晋一郎, 水町博之, 御手洗裕美, 和田尚久, 清島保, 前田英史

第146回日本歯科保存学会春季学術大会 2017.6

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：青森市 Country：Japan
口腔粘膜の痛みとTRPV4の発現

#吉本怜子、@合島怜央奈、@大山順子、吉住潤子、@清島保、@城戸瑞穂

第14回TRPチャネル研究会 2018.5

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Event date： 2018.5

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
温度感受性イオンチャネルTRPV4を介した口腔上皮細胞間接着と細胞移動の制御 International conference

#吉本怜子、@合島怜央奈、@西山めぐみ、@大崎康吉、@張旌旗、@清島保、@城戸瑞穂

ConBio2017(2017年度生命科学系学会合同年次大会) 2017.12

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸 Country：Japan
温度感受性イオンチャネルTRPV4による口腔上皮細胞の細胞間接着および細胞移動の制御

#吉本怜子、@清島保、@西村英紀、@城戸瑞穂

第147回日本歯科保存学会学術大会 2017.10

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Event date： 2017.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：盛岡 Country：Japan
温度感受性イオンチャネルTRPV4は口腔上皮細胞の細胞間接着と運動性を制御する

#吉本怜子、@合島怜央奈、@大崎康吉、@張旌旗、#曹愛琳、@Gao Wei Qi, @清島保、@城戸瑞穂

第59回歯科基礎医学会大会 2017.9

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Event date： 2017.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：松本 Country：Japan
ヒト肺癌(腺癌および肺扁平上皮癌)におけるArl4cの発現は癌形成を促進する

@藤井慎介, @清島　保, @松本真司

第59回歯科基礎医学会大会 2017.9

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Event date： 2017.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：松本 Country：Japan
Epithelial barrier disorganization and oral pain. International conference

#Reiko U. Yoshimoto, @Reona Aijima, @Yukiko Ohyama, @Junko Yoshizumi, @Tamotsu Kiyoshima, @Mizuho A. Kido

Gender Summit Satellite Symposium 2017.5

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Event date： 2017.5

Language：English Presentation type：Oral presentation (general)

Country：Japan
ヒト肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する

@藤井慎介、 @松本真司、@清島保、@菊池章

第106回日本病理学会総会 2017.4

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Event date： 2017.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
顎関節に生じた色素性絨毛結節性滑膜炎の１例

望月敬太、松村香織、大部一成、森山雅文、新井伸作、三上友里恵、清島保、中村誠司

第71回 NPO法人日本口腔科学会学術集会 2017.4

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Event date： 2017.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：松山市 Country：Japan
ヒト大腸癌、肺腺癌および肺扁平上皮癌におけるArl4cの発現はがん形成を促進する

藤井慎介, 松本　真司, 清島保, 菊池　章

第62回日本病理学会秋期特別総会 2016.11

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Event date： 2016.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：金沢 Country：Japan
上顎歯肉に発症したメトトレキサート関連リンパ増殖性疾患の1例

古川　祥子, 大部一成, 林田淳之介, 佐古　沙織, 森山雅文, 新井伸作, 松原良太, 清島保, 中村誠司

第34回日本口腔腫瘍学会科学会 2016.1

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Event date： 2016.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：横浜 Country：Japan
診断に苦慮した口底部類皮嚢胞の１例

石黒　乃理子, 見立英史, 大部一成, 森岡　政彦, 清島保, 中村誠司

日本口腔外科学会・第83回九州支部学術集会 2015.6

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
シェーグレン症候群を背景にした耳下腺、口唇腺MALTリンパ腫の1例

大山順子, 吉川浩世, 山田朋弘, 清水真弓, 森山雅文, 古川祥子, 清島保, 森悦秀

第24回日本口腔内科学会・第27回日本口腔診断学会合同学術大会 2014.9

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Event date： 2014.9

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
急速な増大から悪性腫瘍を強く疑った類腱線維腫の1例

星野亜紀, 杉浦剛, 木附智子, 熊丸渉, 中野旬之, 岡村和俊, 清島保, 森悦秀

第67回日本口腔科学会総会 2013.5

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Event date： 2013.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：宇都宮市 Country：Japan
嚢胞構造を伴った舌神経症腫の1例

岸川咲吏、武富孝治、後藤雄一、辻口友美、大部一成、筑井徹、清島保、中村誠司

第45回日本口腔科学会九州地方部会 2012.11

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Event date： 2012.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
著明な嚢胞化を伴った顎下腺多形腺腫の1例

後藤雄一、川野真太郎、大部一成、清島　保、中尾　祐、森　康一郎、清末崇裕、松原良太、白土雄司、中村誠司

第54回日本口腔外科学会総会・学術大会 2009.10

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Event date： 2009.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
歯原性細胞のMatrix metalloproteinase発現調節機構におけるThymosinβ４の効果について

小林家吉、大隈由紀子、清島　保、永田健吾、吹譯景子、藤原弘明、Naher Lutfan、野中和明、坂井英隆

第49回日本組織細胞化学総会・学術集会 2008.10

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Event date： 2009.10

Presentation type：Oral presentation (general)

Venue：長崎 Country：Japan
歯原性細胞におけるThymosin β4を介したMatrix metalloproteinaseの発現調節について

大隈由紀子、小林家吉、清島保、吹譯景子、永田健吾、藤原弘明、野中和明、坂井英隆

第50回歯科基礎医学会 2008.9

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Event date： 2008.9

Presentation type：Oral presentation (general)

Country：Japan
当科における舌下腺腫瘍の臨床統計的検討

梅津健太郎、川野真太郎、中尾祐、大部一成、中山英二、河津俊幸、小林家吉、清島保、中村誠司

第61回日本口腔科学会総会 2007.4

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Event date： 2007.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸市 Country：Japan
Action of PRIP, an Ins(1,4,5)P3 binding protein, in insulin secretion. International conference

Takashi Kanematsu, Seijiro Shioi, Tamotsu Kiyoshima, Hidetaka Sakai, Masato Hirata.

2008.4

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Presentation type：Oral presentation (general)

Country：United States

Action of PRIP, an Ins(1,4,5)P3 binding protein, in insulin secretion.
Cell proliferation and cell death during odontogenesis in the mouse International conference

Noriatsu Shigemura, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Kou Matsuo, Haruyoshi Yamaza, Akifumi Akamine and Hidetaka Sakai

General Session and Exhibition of the International Association for Dental Research 1999.3

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Presentation type：Oral presentation (general)

Country：Canada

Cell proliferation and cell death during odontogenesis in the mouse
Detection of differentially expressed genes in murine embryonic mandibles International conference

K. Matsuo, I. Kobayashi, T. Kiyoshima, H. Sakai

General Session and Exhibition of the International Association for Dental Research 2001.1

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Presentation type：Oral presentation (general)

Country：Japan

Cell proliferation and cell death during odontogenesis in the mouse
破骨細胞における分化・活性化因子のオートクライン制御

山座　貴子、清島　保、小林　家吉、松尾　拡、坂井　英隆

第93回日本病理学会総会 2004.6

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Presentation type：Oral presentation (general)

Venue：北海道　札幌市 Country：Japan
口腔扁平上皮癌細胞株におけるSCCA1、SCCA2遺伝子発現の腫瘍形成能への影響

橋本　憲一郎、清島　保、松尾　拡、小林　家吉、坂井　英隆

第93回日本病理学会総会 2004.6

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Presentation type：Oral presentation (general)

Venue：北海道　札幌市 Country：Japan
歯胚形成過程におけるNucleolinおよびRibosomal Protein L21遺伝子発現の検索

謝　明、小林　家吉、松尾　拡、清島　保、本田　淳也、山座　貴子、坂井　英隆

第46回歯科基礎医学会学術大会ならびに総会 2004.9

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Presentation type：Oral presentation (general)

Venue：広島　広島市 Country：Japan
歯胚形成過程におけるthymosin beta-4の発現様式

松尾　拡、小林　家吉、清島　保、坂井　英隆

第46回歯科基礎医学会学術大会ならびに総会 2004.9

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Presentation type：Oral presentation (general)

Venue：広島　広島市 Country：Japan
SCCAはシトクロムc放出抑制により口腔扁平上皮癌細胞株のTNF-a誘導細胞死を抑制する。

橋本　憲一郎、清島　保、松尾　拡、小林　家吉、坂井　英隆

第94回　日本病理学会総会 2005.4

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Presentation type：Oral presentation (general)

Venue：神奈川　横浜市 Country：Japan
扁平上皮癌におけるS100A7遺伝子の発現抑制

清島　保、小林家吉、坂井英隆

第47回歯科基礎医学会学術大会ならびに総会 2005.9

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Presentation type：Oral presentation (general)

Venue：宮城　仙台市 Country：Japan
歯胚発生期における解糖系酵素PGK-1の役割

本田淳也、小林家吉、清島　保、謝　明、中島昭彦、坂井英隆

第47回歯科基礎医学会学術大会ならびに総会 2005.9

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Presentation type：Oral presentation (general)

Venue：宮城　仙台市 Country：Japan
S100A7の扁平上皮癌における発現調節機構の解析

福沢秀昭、清島　保、橋本憲一郎、前田顕之、小林家吉、坂井英隆、大関　悟

第50回日本口腔外科学会総会 2005.10

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Presentation type：Oral presentation (general)

Venue：大阪　大阪市 Country：Japan
当科における悪性リンパ腫の臨床的検討

吉永光廣、大山順子、竹之下康治、吉住潤子、石橋浩晃、松木良介、佐々木匡理、窪田泰孝、二宮史浩、小林家吉、清島　保、後藤多津子、中村誠司、白砂兼光

第50回日本口腔外科学会総会 2006.10

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Presentation type：Oral presentation (general)

Venue：大阪　大阪市 Country：Japan
術中迅速病理検査の有効性に関する検討

中川久子、石橋浩晃、大部一成、小林家吉、清島保、竹之下康治、中村誠司、白砂兼光

第50回日本口腔外科学会総会 2005.10

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Presentation type：Oral presentation (general)

Venue：大阪　大阪市 Country：Japan
口腔扁平上皮癌細胞株におけるS100A7遺伝子の発現制御

清島　保

第82回九大病理研究会 2005.12

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Presentation type：Oral presentation (general)

Venue：福岡　福岡市 Country：Japan
Possible functions of Pgk1 in the tooth development. International conference

J Honda, I Kobayashi, T Kiyoshima, H Sakai

International symposium -Dental and Craniofacial Morphogenesis and Tissue Regulation- 2006.3

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Presentation type：Oral presentation (general)

Country：Japan
歯胚発生過程におけるthymosin beta 4の発現様式とその役割について

小林家吉、清島　保、坂井英隆

第95回日本病理学会総会 2006.4

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Presentation type：Oral presentation (general)

Venue：東京　新宿 Country：Japan
Possible Function of Thymosin beta 4 in Tooth Development International conference

Keiko Takahashi, Ieyoshi Kobayashi, Tamotsu Kiyoshima and Hidetaka Sakai

The International Association for Dental Research (84th) 2006.6

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Presentation type：Oral presentation (general)

Country：Australia
Roles of Thymosin beta 4 in Developing Tooth Germ International conference

Ieyoshi Kobayashi, Ming Xie, Tamotsu Kiyoshima and Hidetaka Sakai

The 16th International Microscopy Congress 2006.9

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Presentation type：Oral presentation (general)

Country：Japan
Expression and Possible Functional Role of Nucleolin in The Mouse First Molar Development International conference

Ming Xie, Ieyoshi Kobayashi,Tamotsu Kiyoshima and Hidetaka Sakai

The 16th International Microscopy Congress 2006.9

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Presentation type：Oral presentation (general)

Country：Japan
歯胚発生過程におけるthymosin beta 4の役割について

小林家吉、清島　保、榎　規雄、坂井英隆

第48回歯科基礎医学会学術大会ならびに総会 2006.9

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Presentation type：Oral presentation (general)

Venue：神奈川　横浜市 Country：Japan
老化細胞との比較によるマウス歯肉由来線維芽細胞の実験的老化モデルの構築

榎　規雄、清島　保、小林家吉、寺田善博、坂井英隆

第48回歯科基礎医学会学術大会ならびに総会 2006.9

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Presentation type：Oral presentation (general)

Venue：神奈川　横浜市 Country：Japan
歯胚発生過程におけるthymosin beta 4の役割

小林家吉、清島　保、坂井英隆

第83回九大病理研究 2006.12

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Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
歯胚発生過程におけるthymosin beta 4の多元的役割について

小林家吉、清島　保、坂井英隆

第48回日本顕微鏡学会九州支部総会 2006.12

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Presentation type：Oral presentation (general)

Venue：長崎 Country：Japan
インスリン分泌に関わる新規分子PRIPの役割解明

藤井誠, 塩井誠次郎, 清島保, 大池正宏, 坂井英隆, 兼松隆, 平田雅人

２１世紀COEプログラム「大規模コホートに基づく生活習慣病研究教育」 2007.1

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Presentation type：Oral presentation (general)

Venue：九州大学 Country：Japan
PRIPを介したインスリン分泌調節機構の解析

塩井誠次郎、兼松　隆、清島　保、坂井英隆、平田雅人

第2回「口腔健康科学」シンポジウム 2007.2

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Presentation type：Oral presentation (general)

Venue：九州大学 Country：Japan
転写因子NF-k B p65サブユニットによる上皮細胞分化と発毛制御

高田, 川端由子, 清島保, 自見英治郎

Journal of Oral Biosciences Supplement 2023.9 (一社)歯科基礎医学会

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Language：Japanese
腫脹と排膿を繰り返した先天性上唇瘻の1例

木部琴乃, 服部多市, 丸瀬靖之, 光安岳志, 清島保, 中村誠司

小児口腔外科 2022.10 (一社)日本小児口腔外科学会

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歯根嚢胞の病態形成に関与する歯原性上皮細胞の増殖機構の解明

長野良子, 藤井慎介, 清島保

Journal of Oral Biosciences Supplement 2023.9 (一社)歯科基礎医学会

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未分化な扁平上皮癌の特徴を有する舌に生じたclear cell squamous cell carcinoma

長谷川佳那, 藤井慎介, 清島保

日本口腔診断学会雑誌 2023.2 (一社)日本口腔診断学会

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未分化な扁平上皮癌の特徴を有する舌に生じたclear cell squamous cell carcinoma

長谷川佳那, 藤井慎介, 清島保

日本口腔内科学会雑誌 2022.12 (一社)日本口腔内科学会

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当科における小児シェーグレン症候群29例の臨床像についての検討

松澤鎮史, 大山順子, 森山雅文, 長野公喜, 藤永貴大, 坂本瑞樹, 清水真弓, 山田朋弘, 清島保, 中村誠司

日本口腔診断学会雑誌 2023.2 (一社)日本口腔診断学会

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当科における小児シェーグレン症候群29例の臨床像についての検討

松澤鎮史, 大山順子, 森山雅文, 長野公喜, 藤永貴大, 坂本瑞樹, 清水真弓, 山田朋弘, 清島保, 中村誠司

日本口腔内科学会雑誌 2022.12 (一社)日本口腔内科学会

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唾液腺発生と腺様嚢胞癌腫瘍形成における軸索誘導因子Semaphorin 3A(Sema3A)の役割の解明(Investigation of the role of Semaphorin 3A(Sema3A), an axonal guidance factor, in salivary gland development and adenoid cystic carcinoma tumorigenesis)

藤本龍史, 藤井慎介, 清島保

Journal of Oral Biosciences Supplement 2022.9 (一社)歯科基礎医学会

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口腔癌においてYAPシグナルは異型性および上皮間葉転換を誘導する

長谷川佳那, 藤井慎介, 清島保

日本病理学会会誌 2022.3 (一社)日本病理学会

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口腔扁平上皮癌におけるp63とMAPKシグナルによる低分子量Gタンパク質ARL4Cの発現制御機構解明

藤井慎介, あるかはてぃぶ・だにあ , すろんぐ・てぃん , 長谷川佳那, 長野良子, 清島保

日本病理学会会誌 2023.3 (一社)日本病理学会

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口腔扁平上皮癌においてp63シグナルはYAPシグナルと協調的に細胞内シグナルおよびDNAメチル化を制御する(p63 signaling and YAP signaling cooperatively regulate intracellular signaling and DNA methylation in oral squamous cell carcinoma)

長谷川佳那, 藤井慎介, 清島保

Journal of Oral Biosciences Supplement 2022.9 (一社)歯科基礎医学会

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再発を繰り返す両側性ラヌーラを契機として診断に至った小児シェーグレン症候群の1例

上加世田泰久, 森山雅文, 坂本瑞樹, 村上祐香, 清島保, 川野真太郎

小児口腔外科 2023.11 (一社)日本小児口腔外科学会

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低分子量Gタンパク質ARL4Cの発現はエナメル上皮腫における腫瘍細胞増殖と破骨細胞形成を促進する(RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation)

藤井慎介, 自見英治郎, 清島保

Journal of Oral Biosciences Supplement 2022.9 (一社)歯科基礎医学会

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上顎側切歯部に発生した埋伏歯を伴わない腺腫様歯原性腫瘍の1例

上加世田泰久, 緒方謙一, 川野真太郎, 田中翔一, 清島保, 中村誠司

小児口腔外科 2022.10 (一社)日本小児口腔外科学会

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上皮細胞分化と発毛制御における転写因子NF-κBp65サブユニットの役割

高田, 川端由子, 清島保, 自見英治郎

日本生化学会大会プログラム・講演要旨集 2023.10 (公社)日本生化学会

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エナメル上皮腫における低分子量Gタンパク質ARL4Cの発現は腫瘍細胞増殖と破骨細胞形成を促進する

藤井慎介, 自見英治郎, 清島保

日本病理学会会誌 2022.3 (一社)日本病理学会

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Wnt経路はYAP1-TGF-β経路を介して歯胚の発生を促進する(Wnt signaling promotes tooth germ development through YAP1-TGF-β signaling)

長野良子, 藤井慎介, 清島保

Journal of Oral Biosciences Supplement 2022.9 (一社)歯科基礎医学会

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MISC

The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis Reviewed

@Shinsuke Fujii, @Tamotsu Kiyoshima

Pathology international. 2023.4

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Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

DOI： 10.1111/pin.13325
発生過程及び疾患発症におけるWnt、ARL4C及びSema3Aの役割(The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis)

Fujii Shinsuke, Kiyoshima Tamotsu

Pathology International 73 ( 6 ) 217 - 233 2023.6 （ ISSN:1320-5463 ）

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Language：English Publisher：John Wiley & Sons Australia, Ltd

Professional Memberships

The Japanese Society for the Temporomandibular Joint
Japanese Association for Oral Biology
Japanese Society of Oral and Maxillofacial Surgeon
Japanese Society for Oral Tumors
Japanese Cancer Association
The Japanese Society for Oral Pathology
The Japanese Society of Pathology
Japanese Society of Pediatric Oral and Maxillofacial Surgery
The Japanese Society of Conservative Dentistry
Japanese Stomatological Society
Japanese Dental Education Association

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Committee Memberships

日本歯科医学教育学会歯学教育モデル・コア・カリキュラム改定　基礎歯学系ワーキンググループ Domestic

2021.4 - 2023.3
Executive Domestic

2020.6 - 2022.6
歯科基礎医学会常任理事 Domestic

2020.6 - 2022.6
Executive Domestic

2020.4 - 2024.3
日本病理学会口腔病理専門医制度運営委員会 Domestic

2020.4 - 2024.3
Executive Domestic

2020.4 - 2022.4
日本病理学会口腔病理専門医制度運営委員会 Domestic

2020.4 - 2022.4
Executive Domestic

2018.8 - 2020.8
日本臨床口腔病理学会常任理事 Domestic

2018.8 - 2020.8
Councilor Domestic

2018.4 - Present
Steering committee member Domestic

2016.5 - 2020.5
日本病理学会口腔病理専門医制度運営委員会 Domestic

2016.5 - 2020.5
Executive Domestic

2016.5 - 2018.5
日本病理学会口腔病理専門医試験委員会 Domestic

2016.4 - 2020.5
日本病理学会口腔病理専門医試験実施委員会委員長 Domestic

2016.1 - 2016.10
日本病理学会口腔病理専門医試験委員 Domestic

2015.4 - 2015.10
Executive Domestic

2014.8 - Present
日本臨床口腔病理学会口腔病理基本画像データベース作成小委員会 Domestic

2014.8 - Present
Councilor Domestic

2013.6 - Present
Councilor Domestic

2013.1 - 2020.6
日本臨床口腔病理学会口腔病理基本画像データベース作成小委員会 Domestic

2009.7 - 2011.8

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Academic Activities

座長（Chairmanship）

第112回日本病理学会総会（下関） 2023.4

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Type：Competition, symposium, etc.

Number of participants：3,000
座長（Chairmanship）

第33回日本臨床口腔病理学会　第32回日本口腔内科学会　第35回日本口腔診断学会（札幌市） 2022.9

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Type：Competition, symposium, etc.

Number of participants：500
座長（Chairmanship）

第64回歯科基礎医学会学術大会（徳島市） 2022.9

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Type：Competition, symposium, etc.

Number of participants：450
座長（Chairmanship）

第111回日本病理学会総会（神戸） 2022.4

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Type：Competition, symposium, etc.

Number of participants：3,500
座長（Chairmanship）

第110回日本病理学会総会（東京） 2021.4

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Type：Competition, symposium, etc.

Number of participants：3,500
Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3

Number of peer-reviewed articles in Japanese journals：0
シンポジウム　コーディネーター兼座長（Chairmanship）

第62回歯科基礎医学会学術大会（鹿児島市） 2020.9 - 2020.10

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Type：Competition, symposium, etc.

Number of participants：750
Japanese Dental Science Review International contribution

2020.8 - Present

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Type：Academic society, research group, etc.
副大会長

第109回日本病理学会総会（福岡市） 2020.7

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Type：Competition, symposium, etc.

Number of participants：3,500
Screening of academic papers

Role(s)： Peer review

2020

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：5

Number of peer-reviewed articles in Japanese journals：0
Screening of academic papers

Role(s)： Peer review

2019

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3

Number of peer-reviewed articles in Japanese journals：2
大会長

第60回歯科基礎医学会学術大会（福岡市） 2018.9

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Type：Competition, symposium, etc.

Number of participants：800
Screening of academic papers

Role(s)： Peer review

2018

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：1

Number of peer-reviewed articles in Japanese journals：2
座長（Chairmanship）

第59回歯科基礎医学会学術大会（長野（松本）） 2017.9

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Type：Competition, symposium, etc.

Number of participants：750
Screening of academic papers

Role(s)： Peer review

2017

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3

Number of peer-reviewed articles in Japanese journals：4
座長（Chairmanship）

第58回歯科基礎医学会学術大会（札幌） 2016.8

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Type：Competition, symposium, etc.
座長（Chairmanship）

第27回日本臨床口腔病理学会（広島） 2016.8

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Type：Competition, symposium, etc.
座長（Chairmanship）

第48回NPO法人日本口腔科学会（九州地方部会）（福岡） 2015.11

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座長（Chairmanship）

第25回日本臨床口腔病理学会（新潟） 2014.8

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Type：Competition, symposium, etc.
スタッフ International contribution

（福岡） 2014.2 - 2014.3

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Type：Competition, symposium, etc.
座長（Chairmanship）

第24回日本臨床口腔病理学会（東京） 2013.8

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Type：Competition, symposium, etc.
Journal of Oral and Maxillofacial Surgery, Medicine and Pathology International contribution

Role(s)： Peer review

2012.10 - Present

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Type：Academic society, research group, etc.
座長（Chairmanship）

研究プロジェクト「口腔健康科学」＆「口腔組織の再生・再建医療」大学院生発表会（福岡） 2012.2

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Type：Competition, symposium, etc.
座長 International contribution

歯学研究院研究プロジェクト「口腔健康科学」＆「口腔組織の再生・再建医療」ワークショップと研究プロジェクト大学院生発表会（福岡） 2012.2

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Type：Competition, symposium, etc.
座長（Chairmanship）

第22回日本臨床口腔病理学会、第5回アジア口腔病理学会 2011.8

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Type：Competition, symposium, etc.
スタッフ International contribution

第22回日本臨床口腔病理学会、第5回アジア口腔病理学（福岡） 2011.8

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Type：Competition, symposium, etc.
スタッフ International contribution

合同ミィーティング - 第6回 “口腔健康科学 “ シンポジウムならびに “口腔組織の再生・再建医療研究”シンポジウム（福岡） 2011.3

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Type：Competition, symposium, etc.
座長（Chairmanship） International contribution

The 5th International Symposium on “Dental and Craniofacial Morphogenesis and Tissue Regeneration: A View from Stem Cell Research”. 2010.2

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Type：Competition, symposium, etc.
スタッフ International contribution

合同ミィーティング - 第5回 “口腔健康科学 “ シンポジウムならびに “口腔組織の再生・再建医療研究”シンポジウム（福岡） 2010.2

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Type：Competition, symposium, etc.
スタッフ International contribution

合同ミィーティング - 第4回 “口腔健康科学 “ シンポジウムならびに“口腔組織の再生・再建医療研究”シンポジウム（福岡） 2009.2

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Type：Competition, symposium, etc.
スタッフ

第3回医療系大学e-ラーニング全国交流会（福岡） 2009.1

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Type：Competition, symposium, etc.
スタッフ International contribution

合同ミィーティング - 第3回 “口腔健康科学 “ シンポジウムならびに“口腔組織の再生・再建医療研究”シンポジウム（福岡） 2008.1

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Type：Competition, symposium, etc.
スタッフ International contribution

第1回“口腔組織の再生・再建医療研究”シンポジウム（福岡） 2007.3

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Type：Competition, symposium, etc.
スタッフ International contribution

第2回“口腔組織の再生・再建医療研究”シンポジウム（福岡） 2007.3

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Type：Competition, symposium, etc.
座長（Chairmanship） International contribution

2006.3 - Present

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Type：Competition, symposium, etc.

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Research Projects

Elucidation of the mechanism of resistance acquisition to super-enhancer-targeted anticancer therapies and novel strategies based on this mechanism

Grant number：24K22193 2024.6 - 2027.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

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Grant type：Scientific research funding

CiNii Research
Elucidation of the mechanism of jaw bone destruction caused by oral tumor-stromal interaction.

Grant number：24K02615 2024.4 - 2028.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

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Grant type：Scientific research funding

CiNii Research
Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.

Grant number：23K27792 2024 - 2026

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

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Authorship：Principal investigator Grant type：Scientific research funding

CiNii Research
超早期癌発見戦略に向けた変異細胞-隣接正常細胞-間質細胞における不安定性出現解明

Grant number：23H03102 2023 - 2026

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
口腔細胞診における遺伝子検査法（GSC）の創出とその臨床応用

Grant number：23K11897 2023 - 2026

日本学術振興会科学研究費助成事業基盤研究(C)

山口知彦, 清島保, 藤井慎介, 野上美和子

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

診療では、臨床診断および細胞診・生検により病理診断される。口腔腫瘍、特に悪性腫瘍では、治療後の定期的な経過観察が重要である。細胞診は非健常部位の細胞を擦りとる検査であり、スクリーニングと推定診断を目的とする。細胞診・生検では、細胞・組織型の分類はなされるが、数値による基準値が設定されていないため、患者にとって診断結果を理解しやすい検査とは言い難い。本研究では、細胞診試料における口腔扁平上皮癌の発癌に関与する過剰発現した遺伝子群の発現量を検討する「細胞診を用いた遺伝子検査法（GSC; Genetic Screening Cytology」を創出する。また、検査値に基づく経過観察への展開を目指す。

CiNii Research
Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration

Grant number：23K09140 2023 - 2025

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

CiNii Research
Elucidation of novel regulatory mechanism of bone metabolism by epithelial cells

Grant number：23K18363 2023 - 2024

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Challenging Research(Exploratory)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

CiNii Research
早期癌に認められる異型におけるHippo-YAPシグナルの機能解析

Grant number：21K09843 2021 - 2023

日本学術振興会科学研究費助成事業基盤研究(C)

長谷川佳那, 清島保, 藤井慎介, 和田裕子

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

悪性腫瘍の早期発見・早期治療は予後に大きく影響する。口腔癌では90％以上を口腔扁平上皮癌（Oral squamous cell carcinoma; OSCC）が占める。OSCCでは他の癌腫において治療標的となる遺伝子異常が少ないことが報告されているため、異常活性化した細胞内シグナルが発癌に寄与すると予想される。そのため異常に活性化した細胞内シグナルとその異常を引き起こす責任分子を同定することを目的とする。本研究結果はOSCCの診断に有用な新規マーカーや治療標的分子の発見に繋がると期待される。

CiNii Research
Analysis of new regulatory mechanism of protein deamidation and it's functional using oral cancer cells

Grant number：21K19609 2021 - 2022

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Challenging Research(Exploratory)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

CiNii Research
Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy

Grant number：20K10096 2020 - 2022

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Principal investigator Grant type：Scientific research funding

CiNii Research
歯原性間葉系幹細胞誘導因子の同定と歯の再生への応用

Grant number：20K09920 2020 - 2022

日本学術振興会科学研究費助成事業基盤研究(C)

和田裕子, 清島保, 藤井慎介, 長谷川佳那

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

「歯の再生医療」の具現化には、上皮間葉相互作用を含む歯の発生メカニズムの解明が重要である。
我々はこれまでに歯胚上皮由来のエナメル質形成に重要な因子を認めた。
しかしながら、歯の主体をなす歯胚間葉由来の象牙質の発生に関わる特異的な因子の同定には至っていない。
そこで本研究では、微量RNA seq解析により歯胚発生過程の上皮間葉相互作用における間葉系幹細胞に重要な特異的因子を同定し、その発現様式と分子機構および機能を解析する。

CiNii Research
Elucidating the mechanisms to induce ameloblastoma and its trial for the clinical setting

Grant number：20K09906 2020 - 2022

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Fujii Shinsuke

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Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports revealed that ameloblastoma harbors an oncogenic BRAF V600E mutation with MAPK pathway activation. However, the precise mechanism by which MAPK pathway induces ameloblastoma is unclear. In immunohistochemical analyses of tissue specimens obtained from ameloblastoma patients, ARL4C was frequently expressed with both BRAF V600E and RAF1. ARL4C-depleted tumour cells exhibited decreased proliferation and migration capabilities. Finally, when ameloblastoma cells were co-cultured with mouse bone marrow cells and primary osteoblasts, ameloblastoma cells induced osteoclast formation. ARL4C elevation in ameloblastoma further promoted its formation capabilities. These results suggest that the RAF1-MEK/ERK-ARL4C axis, which may function in cooperation with the BRAF V600E-MEK/ERK pathway, promotes ameloblastoma development.

CiNii Research
Wnt経路の新規下流シグナルの腺様嚢胞癌における機能解析と新規治療法の開発

Grant number：20K10107 2020 - 2022

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
癌微小環境の機械侵襲と新規癌遺伝子シグナル制御の相互強化による新たな癌治療戦略

Grant number：19K10302 2019 - 2021

日本学術振興会科学研究費助成事業基盤研究(C)

大関悟, 清島保, 藤井慎介, 田尻祐大

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

これまでの癌研究では、腫瘍を構成する実質と間質とが各々個別に検討されてきたが、一方のみを標的とする試みだけでは十分な抗腫瘍効果をあげられない場合がある。臨床において固形癌の周囲に触れる硬結が癌の進行を促進する可能性について報告されているが、その分子基盤は不明である。本研究では、機械受容器であるTRPV4が腫瘍間質の硬結を感知することによって腫瘍実質の増殖に与える影響を明らかにする。また、研究分担者らは腫瘍実質における新規癌遺伝子を見出している。
本研究では、腫瘍間質からと腫瘍実質を併せて標的とする、これまでにない抗腫瘍効果を目指した癌治療法の開発を企図している。

CiNii Research
癌の微小環境構築に関わるkey regulatorを標的とした新しい癌治療戦略

Grant number：18H03004 2018 - 2020

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
メカノセンサーを基盤とした歯の発生メカニズムの解明

Grant number：17K11616 2017 - 2019

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
TRPチャンネルを介したがん組織微小環境ストレスによる癌細胞形質への影響の解明

Grant number：16K11738 2016 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯―歯肉付着上皮の封鎖を標的とした歯周病制御

Grant number：16H05558 2016 - 2018

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
メカノセンサー欠損によるエナメル質形成不全

Grant number：16K11447 2016 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
エナメル質形成における分子シャペロンGRP78の関与

Grant number：16K11448 2016 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯根膜幹細胞誘導による組織再生を基盤とした包括的歯内疾患治療法の開発

Grant number：15H05023 2015 - 2018

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
非コードRNA-RNA相互作用ネットワークによる口腔扁平上皮癌の癌形質制御の試み

Grant number：15H15695 2015 - 2016

科学研究費助成事業挑戦的萌芽研究

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Authorship：Principal investigator Grant type：Scientific research funding
扁平上皮癌細胞特異的遺伝子をターゲットにした新規癌治療法の開発

Grant number：26462788 2014 - 2016

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
薬剤抵抗性口腔扁平上皮癌におけるSTAT3の腫瘍抑制系ネットワークへの関与

Grant number：25463124 2013 - 2015

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚の形態形成におけるPP2Aインヒビターの細胞内シグナル伝達制御機構の解明

Grant number：25462862 2013 - 2015

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
変異型DCC遺伝子を利用した口腔癌細胞のアポトーシス誘導

Grant number：25670779 2013 - 2014

科学研究費助成事業挑戦的萌芽研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
遺伝子Xの発現量調節による歯原性幹細胞作出の試み

Grant number：23659859 2011 - 2013

科学研究費助成事業挑戦的萌芽研究

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Authorship：Principal investigator Grant type：Scientific research funding
ＰＥＴトレーサを応用した標的蛋白発現トリガー／安定化リガンドによる癌治療法の開発

Grant number：23659880 2011 - 2012

科学研究費助成事業挑戦的萌芽研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚形態形成におけるサイモシンベーター 4を中心とした分子ネットワークの解明

Grant number：21592331 2009 - 2011

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
炎症性サイトカインシグナルSTATの扁平上皮癌におけるin vivo評価法の開発

Grant number：80117077 2009 - 2010

科学研究費助成事業挑戦的萌芽研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚形成過程における新規膜蛋白を介した細胞内外分子相互作用の解析

Grant number：20390466 2008 - 2011

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚形成過程における神経軸索誘導因子受容体DCC関連シグナル機構の機能解析

2007 - 2010

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
歯胚発育におけるThymosin beta4を介したゼラチナーゼ活性化機構の解明

2007 - 2008

科学研究費助成事業特定領域研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚の発生・発育・分化におけるThymosin beta4 の多元的分子機構の解明

2007 - 2008

科学研究費助成事業萌芽研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
扁平上皮癌における神経軸索ガイダンス関連因子による細胞死制御機構の解析とその応用

2007 - 2008

科学研究費助成事業萌芽研究

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Authorship：Principal investigator Grant type：Scientific research funding
口腔扁平上皮癌の細胞相互接着によるアノイキス抵抗性変化と腫瘍関連蛋白の解明

2006 - 2009

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
ヒト間葉系細胞を用いた新規三次元培養法によるブロック骨迅速形成システムの開発

2006 - 2007

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
扁平上皮癌腫瘍塊へのアノイキス機構回復による癌治療を目指した研究方法の開発

2006 - 2007

科学研究費助成事業萌芽的研究

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Authorship：Principal investigator Grant type：Scientific research funding
歯周組織の加齢変化に対するanti-aging療法の基礎的研究

2006 - 2007

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚発生過程におけるThymosin beta 4の機能解析

Grant number：18590169 2006 - 2007

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
口腔扁平上皮癌に対する個別化制限増殖型遺伝子治療法を目指した基礎的研究とその応用

Grant number：17390548 2005 - 2008

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚幹細胞の同定・単離と、その増殖・分化の分子機構の解明

Grant number：17390487 2005 - 2007

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚幹細胞の分離およびその表面マーカーの検索

2005 - 2006

科学研究費助成事業特定領域研究(A)特定領域研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
扁平上皮癌標的分子の特異的発現機構に基づく個別化治療法の開発を目指した基礎的研究

Grant number：17659643 2005 - 2006

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚幹細胞の同定および未分化維持機構の解析

2005 - 2006

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
新しい歯胚形成関連遺伝子群の機能解析

Grant number：16591830 2004 - 2005

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
口腔癌遺伝子治療用Epstein-Barrウイルスベクター開発の基礎的研究

2004 - 2005

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
扁平上皮癌におけるS100蛋白の発現調節機構とその標的分子のプロテオーム解析

2004

科学研究費助成事業特定領域研究(A)特定領域研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
歯胚幹細胞の分離・同定および歯牙再生医療への応用

2003 - 2006

日本学術振興会科学研究費助成事業基盤研究(A)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
癌遺伝子治療用Epstein-Barrウイルスベクタ−開発の基礎的研究

2003 - 2005

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
ファージ型抗体と細胞表面抗原レプリカペプチドを応用した歯牙再生法の開発

2003 - 2005

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯周組織の加齢変化に関する分子機構の解明とその制御法の開発

2003 - 2005

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
“扁平上皮癌標的型攻撃ベクター”の開発と腫瘍細胞の多様性への対策

2003 - 2004

科学研究費助成事業特定領域研究(A)特定領域研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
ファージ抗体システムを利用したがん細胞と間葉細胞の相互作用解析ツールの開発

2003 - 2004

科学研究費助成事業特定領域研究(A)特定領域研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯胚幹細胞の単離・同定と組織工学的手法による歯牙再生に関する包括的研究。

2002 - 2005

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
ＥＢウイルス遺伝子導入による口腔癌細胞の形質転換と遺伝子治療への応用。

2002 - 2005

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
造腫瘍能に関連する新しい因子の同定、機能解析および癌治療応用への基礎的研究。

2002 - 2005

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
造腫瘍能に関する新しい因子の同定および癌治療への応用。

2002 - 2004

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
器官培養法を用いた歯胚幹細胞の単離・同定と歯牙再生への応用。

Grant number：14657469 2002 - 2004

科学研究費助成事業萌芽的研究

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
歯牙再生医療に向けた戦略的研究。

2001 - 2005

日本学術振興会科学研究費助成事業基盤研究(S)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

▼display all

Educational Activities

<Undergraduate School>
Pathology/Oral pathology: (Lecture/Exercise) The explanation of the typical pathological specimens based on the lecture, and the instruction of the observation under a microscope
Comprehensive dental science
Research exposure: For fourth and sixth grades, the instruction and the exercise of the molecular biological examination concerning the above-mentioned research as well as pathological diagnosis.

<Graduate School>
The graduate students will study a part of above-mentioned research and write papers on it under instruction to be a "researcher" in the future. Moreover, they will be involved also in autopsy or pathological diagnosis of the oral disease from the department of medical examination so as to understand the fundamentals of pathology.

Class subject

口腔病理学２

2024.12 - 2025.2 Winter quarter
口腔病理学１

2024.10 - 2024.12 Fall quarter
病理学3

2024.10 - 2024.12 Fall quarter
病理学2

2024.6 - 2024.8 Summer quarter
病理学1

2024.4 - 2024.6 Spring quarter
口腔病理学２

2023.12 - 2024.2 Winter quarter
口腔病理学（低年次）D

2023.12 - 2024.2 Winter quarter
Oral Pathology （Lower-grade） D

2023.12 - 2024.2 Winter quarter
口腔病理学（コア） D

2023.12 - 2024.2 Winter quarter
Oral Pathology （Core） D

2023.12 - 2024.2 Winter quarter
口腔病理学（高年次） D

2023.12 - 2024.2 Winter quarter
Oral Pathology （Upper-grade） D

2023.12 - 2024.2 Winter quarter
口腔病理学１

2023.10 - 2023.12 Fall quarter
口腔病理学（低年次）C

2023.10 - 2023.12 Fall quarter
Oral Pathology （Lower-grade） C

2023.10 - 2023.12 Fall quarter
口腔病理学（コア） C

2023.10 - 2023.12 Fall quarter
Oral Pathology （Core） C

2023.10 - 2023.12 Fall quarter
口腔病理学（高年次） C

2023.10 - 2023.12 Fall quarter
Oral Pathology （Upper-grade） C

2023.10 - 2023.12 Fall quarter
病理学3

2023.10 - 2023.12 Fall quarter
病理学2

2023.6 - 2023.8 Summer quarter
口腔病理学（低年次）B

2023.6 - 2023.8 Summer quarter
Oral Pathology （Lower-grade） B

2023.6 - 2023.8 Summer quarter
口腔病理学（コア） B

2023.6 - 2023.8 Summer quarter
Oral Pathology （Core） B

2023.6 - 2023.8 Summer quarter
口腔病理学（高年次） B

2023.6 - 2023.8 Summer quarter
Oral Pathology （Upper-grade） B

2023.6 - 2023.8 Summer quarter
病理学1

2023.4 - 2023.6 Spring quarter
口腔病理学（低年次）A

2023.4 - 2023.6 Spring quarter
Oral Pathology （Lower-grade） A

2023.4 - 2023.6 Spring quarter
口腔病理学（コア） A

2023.4 - 2023.6 Spring quarter
Oral Pathology （Core） A

2023.4 - 2023.6 Spring quarter
口腔病理学（高年次） A

2023.4 - 2023.6 Spring quarter
Oral Pathology （Upper-grade） A

2023.4 - 2023.6 Spring quarter
Oral Pathology （Upper-grade） D

2022.12 - 2023.2 Winter quarter
口腔病理学（低年次）D

2022.12 - 2023.2 Winter quarter
Oral Pathology （Lower-grade） D

2022.12 - 2023.2 Winter quarter
口腔病理学（コア） D

2022.12 - 2023.2 Winter quarter
Oral Pathology （Core） D

2022.12 - 2023.2 Winter quarter
口腔病理学（高年次） D

2022.12 - 2023.2 Winter quarter
Oral Pathology （Upper-grade） C

2022.10 - 2022.12 Fall quarter
口腔病理学（低年次）C

2022.10 - 2022.12 Fall quarter
Oral Pathology （Lower-grade） C

2022.10 - 2022.12 Fall quarter
口腔病理学（コア） C

2022.10 - 2022.12 Fall quarter
Oral Pathology （Core） C

2022.10 - 2022.12 Fall quarter
口腔病理学（高年次） C

2022.10 - 2022.12 Fall quarter
Oral Pathology （Upper-grade） B

2022.6 - 2022.8 Summer quarter
口腔病理学（低年次）B

2022.6 - 2022.8 Summer quarter
Oral Pathology （Lower-grade） B

2022.6 - 2022.8 Summer quarter
口腔病理学（コア） B

2022.6 - 2022.8 Summer quarter
Oral Pathology （Core） B

2022.6 - 2022.8 Summer quarter
口腔病理学（高年次） B

2022.6 - 2022.8 Summer quarter
口腔病理学

2022.4 - 2023.3 Full year
Oral Pathology （Upper-grade） A

2022.4 - 2022.6 Spring quarter
口腔病理学（低年次）A

2022.4 - 2022.6 Spring quarter
Oral Pathology （Lower-grade） A

2022.4 - 2022.6 Spring quarter
口腔病理学（コア） A

2022.4 - 2022.6 Spring quarter
Oral Pathology （Core） A

2022.4 - 2022.6 Spring quarter
口腔病理学（高年次） A

2022.4 - 2022.6 Spring quarter
Oral Pathology （Upper-grade） D

2021.12 - 2022.2 Winter quarter
口腔病理学（低年次）D

2021.12 - 2022.2 Winter quarter
Oral Pathology （Lower-grade） D

2021.12 - 2022.2 Winter quarter
口腔病理学（コア） D

2021.12 - 2022.2 Winter quarter
Oral Pathology （Core） D

2021.12 - 2022.2 Winter quarter
口腔病理学（高年次） D

2021.12 - 2022.2 Winter quarter
Oral Pathology （Upper-grade） C

2021.10 - 2021.12 Fall quarter
口腔病理学（低年次）C

2021.10 - 2021.12 Fall quarter
Oral Pathology （Lower-grade） C

2021.10 - 2021.12 Fall quarter
口腔病理学（コア） C

2021.10 - 2021.12 Fall quarter
Oral Pathology （Core） C

2021.10 - 2021.12 Fall quarter
口腔病理学（高年次） C

2021.10 - 2021.12 Fall quarter
Oral Pathology （Upper-grade） B

2021.6 - 2021.8 Summer quarter
口腔病理学（低年次）B

2021.6 - 2021.8 Summer quarter
Oral Pathology （Lower-grade） B

2021.6 - 2021.8 Summer quarter
口腔病理学（コア） B

2021.6 - 2021.8 Summer quarter
Oral Pathology （Core） B

2021.6 - 2021.8 Summer quarter
口腔病理学（高年次） B

2021.6 - 2021.8 Summer quarter
口腔病理学

2021.4 - 2022.3 Full year
Oral Pathology

2021.4 - 2022.3 Full year
細胞培養の理論と応用

2021.4 - 2022.3 Full year
Oral Pathology （Upper-grade） A

2021.4 - 2021.6 Spring quarter
口腔病理学（低年次）A

2021.4 - 2021.6 Spring quarter
Oral Pathology （Lower-grade） A

2021.4 - 2021.6 Spring quarter
口腔病理学（コア） A

2021.4 - 2021.6 Spring quarter
Oral Pathology （Core） A

2021.4 - 2021.6 Spring quarter
口腔病理学（高年次） A

2021.4 - 2021.6 Spring quarter
臨床病理学

2020.4 - 2021.3 Full year
口腔病理学

2020.4 - 2021.3 Full year
細胞培養の理論と応用

2020.4 - 2021.3 Full year
口腔顎顔面病態学研究入門（口腔病理学）

2020.4 - 2021.3 Full year
口腔顎顔面病態学臨床実習Ⅱ（口腔病理学）

2020.4 - 2021.3 Full year
統合歯科学特別研究（口腔病理学）

2020.4 - 2021.3 Full year
臨床基礎演習（口腔病理学）

2020.4 - 2021.3 Full year
口腔病理学

2019.4 - 2020.3 Full year
口腔顎顔面病態学特論（口腔病理学）

2019.4 - 2020.3 Full year
口腔顎顔面病態学臨床実習Ⅱ（口腔病理学）

2019.4 - 2020.3 Full year
統合歯科学特別研究（口腔病理学）

2019.4 - 2020.3 Full year
臨床基礎演習（口腔病理学）

2019.4 - 2020.3 Full year
臨床病理学

2019.4 - 2020.3 Full year
口腔組織学１

2019.4 - 2019.9 First semester
口腔顎顔面病態学臨床実習Ⅱ（口腔病理学）

2018.4 - 2019.3 Full year
口腔病理学

2018.4 - 2019.3 Full year
口腔病理学

2018.4 - 2019.3 Full year
臨床病理学

2018.4 - 2019.3 Full year
統合歯科学特別研究（口腔病理学）

2018.4 - 2019.3 Full year
細胞生物学特論

2018.4 - 2019.3 Full year
細胞培養の理論と応用

2018.4 - 2019.3 Full year
臨床基礎演習（口腔病理学）

2018.4 - 2019.3 Full year
口腔組織学１

2018.4 - 2018.9 First semester
臨床病理学

2017.4 - 2018.3 Full year
口腔病理学

2017.4 - 2018.3 Full year
Introduction to Oral Biological Research(口腔病理学H29.4-)

2017.4 - 2018.3 Full year
Oral Pathology(口腔病理学H29.4-）

2017.4 - 2018.3 Full year
口腔顎顔面病態学研究入門（口腔病理学）

2017.4 - 2018.3 Full year
口腔顎顔面病態学臨床実習Ⅰ（口腔病理学）

2017.4 - 2018.3 Full year
細胞生物学特論

2017.4 - 2018.3 Full year
細胞培養の理論と応用

2017.4 - 2018.3 Full year
Oral Pathology(口腔病理学H28.10-)

2017.4 - 2017.9 First semester
口腔組織学１

2017.4 - 2017.9 First semester
細胞生物学特論

2016.10 - 2017.3 Second semester
口腔病理学

2016.4 - 2017.3 Full year
口腔顎顔面病態病理学

2016.4 - 2017.3 Full year
口腔顎顔面病態病理学演習

2016.4 - 2017.3 Full year
組織学Ⅰ

2016.4 - 2016.9 First semester
細胞生物学特論

2015.10 - 2016.3 Second semester
口腔病理学

2015.4 - 2016.3 Full year
口腔顎顔面病態病理学演習

2015.4 - 2016.3 Full year
口腔顎顔面病態病理学

2015.4 - 2016.3 Full year
組織学Ⅰ

2015.4 - 2015.9 First semester
臨床病理学

2014.4 - 2015.3 Full year
口腔病理学

2014.4 - 2015.3 Full year
口腔顎顔面病態病理学

2014.4 - 2015.3 Full year
Oral Pathology

2014.4 - 2015.3 Full year
口腔顎顔面病態病理学演習

2014.4 - 2015.3 Full year
細胞培養の理論と応用

2014.4 - 2014.9 First semester
組織学Ⅰ

2014.4 - 2014.9 First semester
口腔顎顔面病態病理学演習

2013.4 - 2014.3 Full year
口腔病理学

2013.4 - 2014.3 Full year
歯学総論I

2013.4 - 2014.3 Full year
臨床病理学

2013.4 - 2014.3 Full year
口腔顎顔面病態病理学

2013.4 - 2014.3 Full year
細胞培養の理論と応用

2013.4 - 2013.9 First semester
生物科学II

2013.4 - 2013.9 First semester
組織学Ⅰ

2013.4 - 2013.9 First semester
口腔顎顔面病態病理学

2012.4 - 2013.3 Full year
口腔病理学

2012.4 - 2013.3 Full year
組織学Ⅰ

2012.4 - 2013.3 Full year
歯学総論I

2012.4 - 2013.3 Full year
臨床病理学

2012.4 - 2013.3 Full year
口腔顎顔面病態病理学演習

2012.4 - 2013.3 Full year
生物科学II

2012.4 - 2012.9 First semester
生物科学II（口腔の癌）

2011.10 - 2012.3 Second semester
口腔顎顔面病態病理学

2011.4 - 2012.3 Full year
口腔病理学

2011.4 - 2012.3 Full year
組織学Ⅰ

2011.4 - 2012.3 Full year
歯学総論I

2011.4 - 2012.3 Full year
臨床病理学

2011.4 - 2012.3 Full year
口腔顎顔面病態病理学演習

2011.4 - 2012.3 Full year
生物科学II（口腔の癌）

2010.10 - 2011.3 Second semester
口腔顎顔面病態病理学

2010.4 - 2011.3 Full year
口腔病理学

2010.4 - 2011.3 Full year
口腔病理学

2010.4 - 2011.3 Full year
組織学Ⅰ

2010.4 - 2011.3 Full year
臨床病理学

2010.4 - 2011.3 Full year
口腔顎顔面病態病理学演習

2010.4 - 2011.3 Full year
細胞培養の理論と応用

2010.4 - 2010.9 First semester
生物科学II（口腔の癌）

2009.10 - 2010.3 Second semester
口腔顎顔面病態病理学

2009.4 - 2010.3 Full year
口腔病理学

2009.4 - 2010.3 Full year
口腔病理学

2009.4 - 2010.3 Full year
組織学Ⅰ

2009.4 - 2010.3 Full year
口腔病態診断科学演習

2009.4 - 2010.3 Full year
口腔病態診断科学

2009.4 - 2010.3 Full year
臨床病理学

2009.4 - 2010.3 Full year
口腔顎顔面病態病理学演習

2009.4 - 2010.3 Full year
口腔病態診断科学

2008.4 - 2009.3 Full year
口腔病理学

2008.4 - 2009.3 Full year
口腔病理学

2008.4 - 2009.3 Full year
口腔顎顔面病態病理学演習

2008.4 - 2009.3 Full year
口腔顎顔面病態病理学

2008.4 - 2009.3 Full year
臨床病理学

2008.4 - 2009.3 Full year
口腔病態診断科学演習

2008.4 - 2009.3 Full year
口腔病態診断科学

2007.4 - 2008.3 Full year
口腔病理学

2007.4 - 2008.3 Full year
口腔病理学

2007.4 - 2008.3 Full year
口腔病態診断科学演習

2007.4 - 2008.3 Full year
口腔病理学

2006.4 - 2007.3 Full year
口腔病理学

2006.4 - 2007.3 Full year
口腔病理学

2005.4 - 2006.3 Full year
口腔病理学

2004.4 - 2005.3 Full year
口腔病理学

2003.4 - 2004.3 Full year
口腔病理学

2002.4 - 2003.3 Full year

▼display all

FD Participation

2020.6 Role：Participation Title：『ジャーナルをめぐる現状と論文の投稿・入手について』

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.10 Role：Participation Title：『「男女共同参画推進」や「ワークライフバランス推進」のために九州大学に求める今後の支援・施策等』

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.10 Role：Participation Title：「医師のための働き方見直し～ワークライフバランスとダイバーシティの観点から～」「本学の男女共同参画の取り組みについて」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.8 Role：Participation Title：「歯学研究院の研究力分析と研究力強化に向けたScopus/Scival/Pure活用例」「BIツールを用いた研究力分析の紹介」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.5 Role：Participation Title：「臨床実習後臨床能力試験トライアルの実施に向けて」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.3 Role：Participation Title：東京医歯大における国家試験対策の実践

Organizer：[Undergraduate school/graduate school/graduate faculty]
2017.12 Role：Participation Title：ARO次世代医療センターの活用方法

Organizer：[Undergraduate school/graduate school/graduate faculty]
2016.12 Role：Participation Title：#1 歯学教育の現状と課題, #2 反グローバル化と国際交流

Organizer：[Undergraduate school/graduate school/graduate faculty]
2016.10 Role：Participation Title：「なぜ今『女性活躍推進法』か？　　　—男女共同参画の必要性と九州大学における取組み—」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2016.1 Role：Participation Title：平成２７年度アイソトープ統合安全管理センターＦＤ国際規制物資の利用に関する教育講習会

Organizer：University-wide
2015.12 Role：Participation Title：歯学教育の認証評価

Organizer：[Undergraduate school/graduate school/graduate faculty]
2015.9 Role：Participation Title：科研費採択に向けた取り組みに関するFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2015.3 Role：Participation Title：Comparisons between US and European Dental Schools – finances, research and clinical experience

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.10 Role：Participation Title：プロフェッショナリズム教育　—特に卒前教育について、授業を紹介しながら—

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.9 Role：Moderator Title：「科研費獲得のポイント」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.8 Role：Participation Title：新ＧＰＡ制度実施のためのＦＤについて

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.5 Role：Participation Title：新ＧＰＡ制度実施

Organizer：University-wide
2013.11 Role：Participation Title：FDワークショップ「プロフェッショナリズムをどう教えるか」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2013.10 Role：Participation Title：PBLとチューターの役割―昭和大学の学部連携PBLの紹介―

Organizer：[Undergraduate school/graduate school/graduate faculty]
2013.3 Role：Participation Title：「チーム基盤型学習法（Team-Based Learning, TBL）」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2012.9 Role：Participation Title：「Active Learning とPBLチュートリアル教育／PBLチュートリアルチューター講習会」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2012.1 Role：Participation Title：「日本人歯科医師の海外における活動　ー現状と可能性—」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.9 Role：Participation Title：「東日本大震災　歯科医療従事者派遣活動報告」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.9 Role：Participation Title：「PBLチュートリアル教育　チューター講習会 (第２回)」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.1 Role：Participation Title：「昭和大学におけるPBL-チュートリアルの取り組み」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.1 Role：Participation Title：「歯学教育を取り巻く環境変化と求められる対応　＝歯学教育の改善・充実に関する調査研究協力者会議を中心に＝」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.1 Role：Participation Title：「歯科保健医療対策の動向」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2010.12 Role：Participation Title：「医学教育（歯科医学教育）におけるProblem-Based Learning（PBL）の必要性や実践方法について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2010.3 Role：Participation Title：「歯学研究院次期中期目標・計画について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.9 Role：Participation Title：「歯学研究院のQUEST-MAPの最終案について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.8 Role：Participation Title：「職員の処分に関する説明会」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.7 Role：Participation Title：「ニューカッスル大学歯学部を事例とした英国の歯学教育制度の紹介」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.4 Role：Participation Title：「歯学研究院のQUEST-MAP（最終版）について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.3 Role：Participation Title：キャンパス間授業支援システム利用説明会（ＦＤ）

Organizer：University-wide
2008.10 Role：Participation Title：香港大学歯学部の紹介およびPBL教育の実際

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.10 Role：Participation Title：患者の肖像権と個人情報保護

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.4 Role：Participation Title：「歯学研究院のQUEST-MAP（最終版）について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.3 Role：Participation Title：「ＩＴ時代の著作権」(仮題）講演会

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.3 Role：Participation Title：「歯学研究院の現状と将来構想（QUEST-MAP）について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.1 Role：Participation Title：「歯科医療領域の政策・経営シンクタンク」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.12 Role：Participation Title：香港大学歯学部のPBL教育の実際- External Examinerとしての経験から-

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.12 Role：Participation Title：「歯学研究院の理念について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.7 Role：Participation Title：「歯学研究院の課題とその解決策」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.5 Role：Participation Title：「歯学を取り巻く現状分析（その１）」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.4 Role：Participation Title：「歯学研究院の将来を考えるプロジェクト設置について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2007.1 Role：Participation Title：新しい教員組織のあり方について他

Organizer：[Undergraduate school/graduate school/graduate faculty]
2006.7 Role：Participation Title：任期制における中間評価および教員業績評価他について

Organizer：[Undergraduate school/graduate school/graduate faculty]
2006.3 Role：Participation Title：任期制における中間評価および歯学研究院の現状他について

Organizer：[Undergraduate school/graduate school/graduate faculty]
2005.2 Role：Participation Title：WebCT関するFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2003.1 Role：Participation Title：「個人別教育業績評価について（2）」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2002.11 Role：Participation Title：「個人別教育業績評価について」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2002.10 Role：Participation Title：臨床能力評価法としてのOSCEの有用性について

Organizer：[Undergraduate school/graduate school/graduate faculty]
2002.5 Role：Participation Title：米国州立大学及び私立大学歯学部の教育・研究・臨床

Organizer：[Undergraduate school/graduate school/graduate faculty]
2002.4 Role：Participation Title：九大歯学府におけるe-ラーニング

Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

2024 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2024 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1.5時限
2024 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2024 東京医科歯科大学歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2024年6月
2024 愛知学院大学歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2024年6月
2023 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2023 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1.5時限
2023 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2023 愛知学院大学歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2023年6月
2023 広島大学歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2023年6月
2023 鶴見大学歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2023年6月
2022 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2022 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1.5時限
2022 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2022 愛知学院歯学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：2023年2月
2021 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2021 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1.5時限
2021 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2020 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2020 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1.5時限
2020 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2019 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2019 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2019 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2018 長崎大学大学院医歯薬総合研究科 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：1時限
2018 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2018 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2018 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2018 広島大学大学院医歯薬保健学研究科 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：1時限（英語講義）
2017 広島大学大学院医歯薬保健学研究科 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：1時限（英語講義）
2017 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4-7月隔週2時限
2017 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2017 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2017 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2016 広島大学大学院医歯薬保健学研究科 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：1時限（英語講義）
2016 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4-7月隔週2時限
2016 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2016 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2016 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2015 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2015 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2015 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2014 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2014 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2014 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2013 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2013 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月隔週2時限
2013 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-７月隔週2時限、9月-10月週1時限
2012 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週2時限
2012 博多メディカル専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月隔週2時限
2012 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-７月隔週2時限、9月-10月週1時限
2011 福岡歯科大学 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：12-1月週4時限
2011 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2011 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-9月週1時限
2011 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週1時限
2010 福岡歯科大学 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：12-1月週4時限
2010 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2010 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-9月週1時限
2010 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週1時限
2009 福岡医健専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：10-2月週1時限
2009 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2009 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-9月週1時限
2009 福岡歯科大学 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：12-1月週4時限
2008 福岡国際医療福祉学院（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限 (分担)
2008 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-9月週1時限
2008 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2007 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2007 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2006 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2006 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2005 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2005 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2004 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2004 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2003 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2003 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限
2002 博多高等学校（看護専攻科） Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-10月週1時限
2002 福岡医科歯科技術専門学校 Classification:Part-time lecturer Domestic/International Classification:Japan

Semester, Day Time or Duration：4月-7月週1時限

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Participation in international educational events, etc.

2008.2

先端歯学国際教育研究ネットワーク

先端歯学国際教育研究ネットワーク「日英シンポジウム」

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Venue：日本・東京

Other educational activity and Special note

2021 Coaching of Students' Association
2021 Coaching of Students' Association
2021 Special Affairs
2021 Special Affairs
2021 Special Affairs
2021 Special Affairs
2020 Coaching of Students' Association
2020 Coaching of Students' Association
2020 Special Affairs
2020 Special Affairs
2020 Special Affairs
2019 Coaching of Students' Association
2019 Coaching of Students' Association
2019 Special Affairs
2019 Special Affairs
2019 Special Affairs
2018 Coaching of Students' Association
2018 Coaching of Students' Association
2018 Special Affairs
2018 Special Affairs
2018 Special Affairs
2017 Coaching of Students' Association
2017 Coaching of Students' Association
2017 Special Affairs
2017 Special Affairs
2017 Special Affairs
2016 Coaching of Students' Association
2016 Special Affairs
2016 Special Affairs
2015 Special Affairs
2015 Special Affairs
2015 Special Affairs

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Outline of Social Contribution and International Cooperation activities

I work as a members in the dental educational course of JICA in Faculty of Dental Science, Kyushu University, and have the class for the oral pathology and recent data associated with the oral diseases according to the course curriculum .

Social Activities

病理解剖

九州大学病院および関連病院 2021.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2021.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

九州大学病院および関連病院 2020.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2020.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

九州大学病院および関連病院 2019.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2019.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

九州大学病院および関連病院 2018.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2018.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
2019年3月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HoChiMinh city, Vietnamにて学部長（Dr. Ngo Thi Quynh Lan）の都合により、副学長（Dr. Nguyen Van Lan）が主に対応され、副学長の案内にて相手校の病院・講義施設・実習施設を見学し、学生との直接交流を行った。副学長を筆頭に歯学部教員（Dr. Chi Thin Kim Nguyen他）、若手教員および学部学生を対象に英語での講演が行なわれた。学務委員長の築山教授と教務委員長の清島の2名より、九州大学の学生教育とMEXT/Friendship scholarshipsを中心に歯学府および歯学部への留学申請に関する講演（各講演30分、質疑応答15分）をした。また、当該大学から九州大学大学院歯学府に留学中のMEXT scholarship studentが、自身の日本での研究生活と歯学府における研究成果ついて講演した（講演20分、質疑応答10分）。講演終了後には、本学府や学部に留学を希望する学生や教員らの個別相談に応じた。更に、副学長から講演内容のpostview を受け、次年度以降の部局間学生交流協定の更新について双方前向きに審議を進めることとなった。若手研修医と、MEXT scholarship studentを交えてホーチミン市および近郊の歴史的背景、衛生状況、生活状況および健康状況などについての意見・情報交換を行った。

2018

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2019年3月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HoChiMinh city, Vietnamにて
学部長（Dr. Ngo Thi Quynh Lan）の都合により、副学長（Dr. Nguyen Van Lan）が主に対応され、副学長の案内にて相手校の病院・講義施設・実習施設を見学し、学生との直接交流を行った。
副学長を筆頭に歯学部教員（Dr. Chi Thin Kim Nguyen他）、若手教員および学部学生を対象に英語での講演が行なわれた。学務委員長の築山教授と教務委員長の清島の2名より、九州大学の学生教育とMEXT/Friendship scholarshipsを中心に歯学府および歯学部への留学申請に関する講演（各講演30分、質疑応答15分）をした。また、当該大学から九州大学大学院歯学府に留学中のMEXT scholarship studentが、自身の日本での研究生活と歯学府における研究成果ついて講演した（講演20分、質疑応答10分）。講演終了後には、本学府や学部に留学を希望する学生や教員らの個別相談に応じた。
更に、副学長から講演内容のpostview を受け、次年度以降の部局間学生交流協定の更新について双方前向きに審議を進めることとなった。
若手研修医と、MEXT scholarship studentを交えてホーチミン市および近郊の歴史的背景、衛生状況、生活状況および健康状況などについての意見・情報交換を行った。
病理解剖

九州大学病院および関連病院 2017.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2017.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
2017年7-8月　Faculty of Dentistry, University of Gadjah Mada at Yogyakarta, Indonesiaにて午前に野中教授の講演が、研究担当副学部長（Dr. Trianna Wahyu Utami）や小児歯科講師（Dr. Sri Kuswandari）をはじめとする歯学部教員、若手歯科医および学部学生になされ、それに築山教授と共に同席した。講演では、九州大学病院、歯科部門および小児歯科・スペシャルニーズ歯科の診療紹介、加えて小児歯科・スペシャルニーズ歯科の研究が解説された。講演終了後、学生や教員達の質疑に応じた。その後、訪問校の病院施設の見学と学生との直接交流を行った。午後には若手研修医とYogyakarta cityおよび近郊の衛生状況、生活状況および健康状況などについての意見・情報交換を行った。学部長（Dr. Ahmad Syaify）や副学部長らに対し、野中教授と築山教授と共に今回の訪問挨拶、留学希望する学生や若手教員の紹介依頼および意見交換を行った。その後、留学に興味を持つ歯学部学生や若手教員を対象に教務委員長の清島と学務委員長の築山教授の2名から、MEXT scholarshipを中心に九州大学大学院歯学府および歯学部への留学申請および日本での生活に関する講演（45分間の講演と15分間の質疑応答）を行った。更に昼食の時間帯を活用して、上記副学部長らと今後の交流に対する意見交換を行った。また、バリのMahasaraswati Denpasae Universityの学部長（Dr. drg. Dewa Made Wedagama）ら２名も紹介され、意見交換を行った。

2017

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2017年7-8月　Faculty of Dentistry, University of Gadjah Mada at Yogyakarta, Indonesiaにて
午前に野中教授の講演が、研究担当副学部長（Dr. Trianna Wahyu Utami）や小児歯科講師（Dr. Sri Kuswandari）をはじめとする歯学部教員、若手歯科医および学部学生になされ、それに築山教授と共に同席した。講演では、九州大学病院、歯科部門および小児歯科・スペシャルニーズ歯科の診療紹介、加えて小児歯科・スペシャルニーズ歯科の研究が解説された。講演終了後、学生や教員達の質疑に応じた。その後、訪問校の病院施設の見学と学生との直接交流を行った。午後には若手研修医とYogyakarta cityおよび近郊の衛生状況、生活状況および健康状況などについての意見・情報交換を行った。
学部長（Dr. Ahmad Syaify）や副学部長らに対し、野中教授と築山教授と共に今回の訪問挨拶、留学希望する学生や若手教員の紹介依頼および意見交換を行った。
その後、留学に興味を持つ歯学部学生や若手教員を対象に教務委員長の清島と学務委員長の築山教授の2名から、MEXT scholarshipを中心に九州大学大学院歯学府および歯学部への留学申請および日本での生活に関する講演（45分間の講演と15分間の質疑応答）を行った。
更に昼食の時間帯を活用して、上記副学部長らと今後の交流に対する意見交換を行った。また、バリのMahasaraswati Denpasae Universityの学部長（Dr. drg. Dewa Made Wedagama）ら２名も紹介され、意見交換を行った。
病理解剖

千早病院 2016.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
2017年2月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HoChiMinh city, VietnamおよびWindsor Plaza Hotelにて学部長先生（Dr. Ngo Thi Quynh Lan）, 副学長先生を筆頭に歯学部教員および歯学部学生（九州大学歯学部、歯学府および歯学研究院での教育・研究・臨床研修に興味を持っている参加者）を対象に教務委員長の清島（International Graduate Program 2018 of Graduate School of Dental Science, Kyushu University）、当該大学から九州大学大学院歯学府に留学中のMEXT scholarship student (歯学府における研究成果)の2名でそれぞれの内容で準備し、かつ前日にDr. Hoang Trong Hungと事前打合せした講演ファイルについての英語での講演（各自45分間の講演と15分間の質疑応答）を行った。また、野中教授からはMEXT scholarship student の留学経緯の紹介や研究内容の解説を加えた。講演終了後、これから本学府に留学の志を有する学生や教員達の個別相談に応じた。　午後の時間帯で時間の許す範囲での相手校の病院・講義施設・実習施設の見学と学生との直接交流を行った。　更に夕食後の時間帯(19:00～22:00)を活用して、Dr. Hoang Trong Hungと講演内容についてのpostview を受け、次年度の交流推進プログラムの有効的実行プランについての相互確認と意見交換を行った。　その他事前打ち合わせや交流活動を行った。

2016

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2017年2月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at HoChiMinh city, VietnamおよびWindsor Plaza Hotelにて学部長先生（Dr. Ngo Thi Quynh Lan）, 副学長先生を筆頭に歯学部教員および歯学部学生（九州大学歯学部、歯学府および歯学研究院での教育・研究・臨床研修に興味を持っている参加者）を対象に教務委員長の清島（International Graduate Program 2018 of Graduate School of Dental Science, Kyushu University）、当該大学から九州大学大学院歯学府に留学中のMEXT scholarship student (歯学府における研究成果)の2名でそれぞれの内容で準備し、かつ前日にDr. Hoang Trong Hungと事前打合せした講演ファイルについての英語での講演（各自45分間の講演と15分間の質疑応答）を行った。また、野中教授からはMEXT scholarship student の留学経緯の紹介や研究内容の解説を加えた。講演終了後、これから本学府に留学の志を有する学生や教員達の個別相談に応じた。
　午後の時間帯で時間の許す範囲での相手校の病院・講義施設・実習施設の見学と学生との直接交流を行った。
　更に夕食後の時間帯(19:00～22:00)を活用して、Dr. Hoang Trong Hungと講演内容についてのpostview を受け、次年度の交流推進プログラムの有効的実行プランについての相互確認と意見交換を行った。
　その他事前打ち合わせや交流活動を行った。
病理解剖

千早病院 2015.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
2015年10月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh city, Vietnam　を訪問し、学部長先生（Dr. Ngo Thi Quynh Lan）, 副学長先生を筆頭に歯学部教員および歯学部学生（九州大学歯学部、歯学府および歯学研究院での教育・研究・臨床研修に興味を持っている参加者）を対象に清島(International Graduate Program 2017 of Graduate School of Dental Science, Kyushu University)、三木教授 (Dental Education at Kyushu University - Renewed Undergraduate Program)、野中教授(Our Clinical Work and Globalization in Dentistry)の3名で、順にそれぞれのタイトルで準備し、かつ前日にDr. Hoang Trong Hungと事前打合せした講演ファイルについての英語での講演（各自45分間と15分間の質疑応答）を行った。また、自参したInternational Graduate Program of Graduate School of Kyushu UniversityとOutline of Dental Science, Kyushu Universityの資料を配布した。講演終了後、来年度以降に本学府に留学の志を有する学生達の交流会も行った。　午後の時間帯で時間の許す範囲での相手校の病院・講義施設・実習施設の見学と学生との直接交流を行い、学部学生の学習・生活環境を知り得た。

2015

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2015年10月　Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh city, Vietnam　を訪問し、学部長先生（Dr. Ngo Thi Quynh Lan）, 副学長先生を筆頭に歯学部教員および歯学部学生（九州大学歯学部、歯学府および歯学研究院での教育・研究・臨床研修に興味を持っている参加者）を対象に清島(International Graduate Program 2017 of Graduate School of Dental Science, Kyushu University)、三木教授 (Dental Education at Kyushu University - Renewed Undergraduate Program)、野中教授(Our Clinical Work and Globalization in Dentistry)の3名で、順にそれぞれのタイトルで準備し、かつ前日にDr. Hoang Trong Hungと事前打合せした講演ファイルについての英語での講演（各自45分間と15分間の質疑応答）を行った。また、自参したInternational Graduate Program of Graduate School of Kyushu UniversityとOutline of Dental Science, Kyushu Universityの資料を配布した。講演終了後、来年度以降に本学府に留学の志を有する学生達の交流会も行った。　午後の時間帯で時間の許す範囲での相手校の病院・講義施設・実習施設の見学と学生との直接交流を行い、学部学生の学習・生活環境を知り得た。
病理解剖

千早病院 2014.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2013.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2012.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2011.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2010.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2009.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2008.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2007.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2006.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2005.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2004.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2003.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2002.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 2001.11

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1999.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1998.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1997.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1996.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1995.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other
病理解剖

千早病院 1994.9

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other

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Media Coverage

「熱烈発信福岡Now」歯のエナメル質再生に関する研究 TV or radio program

2014.1

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「熱烈発信福岡Now」歯のエナメル質再生に関する研究
歯のエナメル質再生に関する研究 Newspaper, magazine

西日本新聞 2013.12

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歯のエナメル質再生に関する研究
Thymosin beta 4遺伝子導入による歯原性上皮細胞作製の可能性

九州大学プレスリリース 2013.12

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Thymosin beta 4遺伝子導入による歯原性上皮細胞作製の可能性

Acceptance of Foreign Researchers, etc.

University of Medicine and Pharmacy at Ho Chi Minh City

Acceptance period： 2019.12 - 2020.3 （Period）：1 month or more

Nationality：Viet Nam

Business entity：On-campus funds

Travel Abroad

2019.3

Staying countory name 1：Viet Nam Staying institution name 1：University of Medicine and Pharmacy at HoChiMinh city, Vietnam
2017.7 - 2017.8

Staying countory name 1：Indonesia Staying institution name 1：Universitas Gadjah Mada
2017.2

Staying countory name 1：Viet Nam Staying institution name 1：University of Medicine and Pharmacy at HoChiMinh city, Vietnam
2015.10

Staying countory name 1：Viet Nam Staying institution name 1：University of Medicine and Pharmacy at HoChiMinh city, Vietnam
2008.7

Staying countory name 1：Canada Staying institution name 1：IADR
2006.6 - 2006.7

Staying countory name 1：Australia Staying institution name 1：IADR
1999.11 - 2001.11

Staying countory name 1：Canada Staying institution name 1：トロント大学
1999.3

Staying countory name 1：Canada Staying institution name 1：IADR

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Specialized clinical area

Biology / Medicine, Dentistry and Pharmacy / Dentistry / Morphological Basic Dentistry

口腔病理学

Clinician qualification

Specialist

The Japanese Society of Pathology

Year of medical license acquisition

1990

Notable Clinical Activities

口腔顎顔面領域に生じた疾患に対して、生検や術中迅速診断の業務に携わっている。がん診療委員会月例口腔がん部会に委員として参加している。