Updated on 2024/07/28

Information

 

写真a

 
ISHIKAWA KUNIO
 
Organization
Faculty of Dental Science Department of Dental Science Professor
School of Dentistry Department of Dentistry(Joint Appointment)
Graduate School of Dental Science (Joint Appointment)
Graduate School of Dental Science Department of Dental Science(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426344
Profile
I am in charge of biomaterials both in research and in education. Especially, dental materials and biomaterials enginniering will be taught for undergraduate and graduate students, respectivly.
Homepage
External link

Degree

  • Ph. D.

Research History

  • 1986.4-1988.3 東レ株式会社

    1986.4-1988.3 東レ株式会社

  • 1988.4-1997.4 徳島大学 1997.5-2001.10 岡山大学

Research Interests・Research Keywords

  • Research theme:Fabrication of bone substitutes

    Keyword:apatite, apatite cement, cell barrier membrane, biomaterials, inorganic materials, calcium phosphate, tissue regeneration, bone, implant

    Research period: 2012.11 - 2022.3

  • Research theme:Fabrication of bone substitutes

    Keyword:apatite, apatite cement, cell barrier membrane, biomaterials, inorganic materials, calcium phosphate, tissue regeneration, bone, implant

    Research period: 2006.4

  • Research theme:Studies are focused on biomaterials related to the reconstruction and regeneration of hard tissue such as tooth and bone.

    Keyword:apatite, apatite cement, cell barrier membrane, biomaterials, inorganic materials, calcium phosphate, tissue regeneration, bone, implant

    Research period: 1991.1 - 2003.12

Awards

  • 紫綬褒章

    2024.5  

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    氏は、昭和61年3月大阪大学工学研究科前期課程修了後、昭和61年4月東レ(株)入社、昭和64年4月徳島大学歯学部助手、平成9年5月岡山大学歯学部助教授を経て、平成13年11月九州大学大学院歯学研究院教授に就任し、現在に至る。
    超高齢社会の到来に伴い、骨再生術が急増している。骨再生術には骨欠損部を補填する骨補填材が必要であり、人工骨補填材も薬事承認されている。しかし、従来の人工骨補填材は機能が限定的であり、歯科領域においては荷重が負荷されるインプラントを前提とした骨再生術などへの適用は承認されていなかった。そのため、当該部位における骨再生術では患者自身の骨を採取し、骨欠損部に移植する自家骨移植が第一選択であったが、自家骨移植には、健全部位への侵襲、採取可能な自家骨量や形態の制限など重篤な問題があった。
    氏は、溶解析出法という新しい製造方法を発明し、自家骨に匹敵する骨癒合能を備え、骨リモデリングに調和して骨置換される、骨組成(炭酸アパタイト)骨補填材を開発した。
    本開発により、骨組成(炭酸アパタイト)骨補填材は適用制限がない歯科用人工骨補填材として初めて薬事承認され、歯科領域においては荷重が負荷される部位においても自家骨移植が不要になるなど、歯科医療環境を一変させた。また、今後は整形外科用炭酸アパタイト骨補填材としても実用化を見込むなど、国民生活、健康・医療の向上に多大な貢献を果たしている。

  • 第46回(令和3年度)井上春成賞表彰技術

    2021.7   井上春成賞委員会   骨組成(炭酸アパタイト)人工骨

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    骨組成(炭酸アパタイト)人工骨

  • 文部科学大臣表彰(科学技術賞開発部門)

    2020.4   文部科学省   炭酸アパタイト骨補填材の開発

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    骨組成(炭酸アパタイト)の人工骨補填材を開発し、AMED委託開発によって多施設治験を行った。その結果、炭酸アパタイト人工骨補填材はクラスⅣの医療機器として薬事承認され、社会実装(サイトランスグラニュール)されている。
    炭酸アパタイト人工骨補填材は世界で初めて承認された骨組成の人工骨補填材であり、自家骨と同様に骨欠損部で骨に置換される。また、既承認品である水酸アパタイトと比較して旺盛な骨形成が確認されている。そのため、我が国では承認品がなかった歯科インプラントを前提とした骨再建を含む全ての歯科・口腔外科領域において使用できる人工骨補填材として薬事承認された。

  • 第1回 日本オープンイノベーション大賞

    2019.3   内閣府(取りまとめ機関)、総務省、文部科学省、厚生労働省、農林水産省、経済産業省、国土交通省、環境省、一般社団法人日本経済団体連合会、日本学術会議   選考委員会特別賞 骨置換型人工骨「サイトランス グラニュール」の開発と実用化 (中尾潔貴、熊谷知弘、山中克之、石川邦夫、宮本洋二)

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    「サイトランスグラニュール」とは、骨と同じ炭酸アパタイトを組成とする世界初の骨置換型人工骨であり、これまので骨組成に類似した水酸アパタイトを組成とする人工骨と比較すると骨を形成する能力が著しく高いものです。また、水酸アパタイト人工骨は新しい骨に置換されないのに対し、炭酸アパタイトは自家骨(自分の骨)と同様に、新しい骨に置換されるという特徴を持ちます。これまでインプラントを前提とした骨再建術に用いることができる人工骨は承認されていませんでしたが、サイトランスグラニュールは、我が国で初めてインプラントを前提とした骨再建術にも用いることができる骨置換型人工骨として平成29年12月に承認され、平成30年2月より㈱ジーシーから販売されました。

  • 学術賞

    2018.9   日本セラミックス協会   炭酸アパタイト骨補填材の創成

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    骨が炭酸基を6~9%含む炭酸アパタイト(CAp)であることに着目し,炭酸カルシウムブロック等を前駆体とした溶解析出反応により,骨と同程度の炭酸イオンを含むCApブロックを調製する方法を発明し特許を取得するとともに,JCS-Japanをはじめとする学術論文誌にて報告を行った。さらに,得られたCApと長年臨床応用されている水酸アパタイト(HAp)とを病理組織学的に詳細に比較し,このCApがHAp等を圧倒する骨伝導性を示すだけでなく,HApとは異なり骨に置換されることを見いだし,その機序を含めて学術論文にて報告した。

  • ISCM Excellence Award

    2016.10   International Society for Ceramics in Medicine  

  • 応用鉱物科学賞

    2015.10   日本鉱物科学会  

  • Society for Rumanian Biomaterials名誉会員

    2015.9  

  • Raquel LeGerous Senior Award

    2013.6  

  • Special Award of Romanian Society for Biomaterials(ルーマニアバイオマテリアル学会 特別賞 2012)

    2012.6  

  • The Award of Japanese Society for Biomaterials(日本バイオマテリアル学会 学会賞)

    2012.6   日本バイオマテリアル学会   炭酸アパタイトを組成とする高機能骨置換材料の創製

  • 日本歯科理工学会学術講演会発表優秀賞

    2010.4   オゾン処理を用いた骨伝導性チタン材料の創製

  • ABC Award (Asian BioCeramics 2009 best presentation award)

    2009.12  

  • IUMRS奨励賞(International Union of Materials Research Society)

    2008.12   Mechanical Strength Improvement of Cancellous Bone Type Carbonate Apatite Foam. IUMRS-ICA 2008

  • ABC Award (Asian BioCeramics 2008 best presentation award)

    2008.12  

  • 日本歯科理工学会奨励賞

    2004.12   石膏-カルサイト複合体の組成変換反応による炭酸アパタイト骨置換材の創製.

  • ABCaward

    2004.9  

  • 日本口腔インプラント学会デンツプライ賞

    2004.9   「アルギン酸ナトリウムの添加がアパタイトセメントの機械的性質におよぼす影響」

  • 日本歯科理工学会学術講演会発表優秀賞

    2004.4   「バテライト-石こう複合硬化体のリン酸ナトリウム水溶液処理による炭酸アパタイト化

  • 日本歯科理工学会学術講演会発表優秀賞

    2004.4   「チタンおよびチタン合金の擬似口腔内環境における腐食挙動」

  • 日本歯科理工学会学術講演会発表優秀賞

    2004.4   「カルサイトのリン酸塩処理による炭酸アパタイト硬化体の調整」

  • 日本歯科理工学会学術講演会発表優秀賞

    2004.4   「直接覆髄剤の組織為害性について」

  • ABC Award (Asian BioCeramics best presentation award)

    2003.11   Asian BioCeramics Symposium 2003, November 18, 2003, Fukuoka, Japan.  

  • バイオマテリアル科学奨励賞

    1999.11   日本バイオマテリアル学会   高機能性アパタイトセメントへのアプローチ

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Papers

  • Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cement. Reviewed International journal

    Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka, Kazuomi Suzuki:

    Journal of Biomedical Materials Research   1998.1

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    Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cement.

  • Fabrication of magnesium-doped biphasic calcium phosphate granules with sea urchin spine-derived porous structure Reviewed

    Muhammad Amir Jamilludin, @Koichiro Hayashi, Yusril Yusuf, @Kunio Ishikawa

    Ceramics International   2024.4

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  • Lamellar septa-like structured carbonate apatite scaffolds with layer-by-layer fracture behavior for bone regeneration Reviewed

    #Ahmad Nazir Taleb Alashkar,@ Koichiro Hayashi, @Kunio Ishikawa

    Biomimetics   9 ( 2 )   112   2024.2

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  • Transformable carbonate apatite chains as a novel type of bone graft Reviewed

    Advanced Healthcare Materials   13 ( 12 )   2024.1

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    Language:English  

    DOI: https://doi.org/10.1002/adhm.202303245

  • Antibacterial and osteogenic thin film on Ti-6Al-4V surface formed by passivation process in copper hydroxide solution Reviewed

    Science and Technology of Advanced Materials   25   2303327   2024.1

  • Endowing osseointegration ability to bioinert alumina by carbonate apatite coating Reviewed

    @Koichiro Hayashi,@Kunio Ishikawa

    Surfaces and Interfaces   36   2023.10

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    DOI: 10.1016/j.surfin.2022.102617

  • Ant-nest type porous scaffold with micro-struts consisting of carbonate apatite for promoting bone formation and scaffold resorption Reviewed

    #Janice Lay Tin,@Shimabukuro Masaya,@Kobayashi Mamiko,@Kishida Ryo,@Kawashita Masakazu,@Ishikawa Kunio

    Journal of Biomedical Materials Research: Part A   2023.9

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    Language:English  

    DOI: 10.1002/jbm.a.37608

  • Fabrication of low-crystalline Mg-substituted β-tricalcium phosphate foam via dissolution–precipitation reaction Reviewed

    Garima Tripathi, Yuki Sugiura, @Kunio Ishikawa

    46 ( 3 )   149   2023.7

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  • Superiority of triply periodic minimal surface gyroid structure to strut-based grid structure in both strength and bone regeneration Reviewed

    @Koichiro Hayashi, @Ryo Kishida, @Akira Tsuchiya, @Kunio Isikawa

    ACS Applied Materials & Interfaces   15 ( 29 )   34570 - 34577   2023.7

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    Language:English  

    DOI: 10.1021/acsami.3c06263

  • Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration

    Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Computational and Structural Biotechnology Journal   2023.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.csbj.2023.03.053

  • Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks Invited Reviewed

    Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima, Kunio Ishikawa

    ACS Materials Au   2023.4

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    Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks

    DOI: 10.1021/acsmaterialsau.3c00008

  • Fabrication and histological evaluation of ant‐nest type porous carbonate apatite artificial bone using polyurethane foam as a porogen

    111 ( 3 )   560 - 567   2023.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.b.35173

  • Physical property and antimicrobial release ability of gentamicin-loaded apatite cement/α-TCP composites: an in vitro study Reviewed

    16 ( 3 )   2023.1

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    DOI: 10.3390/ma16030995

  • Comparison of bioresorbable bone substitutes, carbonate apatite and β‐tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement

    2023.1

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    DOI: 10.1002/osi2.1170

  • Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure Reviewed

    Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, @Koichiro Hayashi, @Kunio Ishikawa, @Youji Miyamoto

    Journal of Materials Science: Materials in Medicine   34 ( 2 )   2022.12

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  • Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation

    Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Bioengineering   9 ( 11 )   627 - 627   2022.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/bioengineering9110627

  • Comparison of calcite and vaterite as precursors for CO3Ap artificial bone fabrication through a dissolution-precipitation reaction. Reviewed International journal

    #Tanaka K, @Tsuchiya A, Ogino Y, Ayukawa Y, @Ishikawa K

    Ceramics International   48 ( 18 )   26425 - 26431   2022.9

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  • Fabrication and histological evaluation of ant-nest type porous carbonate apatite artificial bone using polyurethane foam as a porogen. Reviewed International journal

    #Tin JTL, @Shimabukuro M, @Kishida R,@ Ishikawa K

    Journal of Biomedical Materials Research : Part B - App Biomater in press   2022.9

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    DOI: https://doi.org/10.1002/jbm.b.35173

  • Effects of scaffold shape on bone regeneration: Tiny shape differences affect the entire system. Reviewed International journal

    @Hayashi K, @Yanagisawa T, @Kishida R, @ Ishikawa K

    ACS Nano   16 ( 8 )   11755 - 11768   2022.7

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    DOI: https://doi.org/10.1021/acsnano.2c03776

  • Osteoclast behaviors on the surface of deproteinized bovine bone mineral and carbonate apatite substitutes in vitro Reviewed

    Masako Fujioka-Kobayashi, Youji Miyamoto, @Kunio Ishikawa, Takafumi Satomi, Benoit Schaller

    J Biomed Mater Res: Part A   2022.4

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    DOI: https://doi.org/10.1002/jbm.a.37392

  • Multiscale porous scaffolds constructed of carbonate apatite honeycomb granules for bone regeneration. Reviewed International journal

    @KoichiroHayashi, @AkiraTsuchiya, @Masaya Shimabukuro, @KunioIshikawa

    Materials & Design   215 ( 110468 )   2022.3

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  • Channel aperture characteristics of carbonate apatite honeycomb scaffolds affect ingrowths of bone and fibrous tissues in vertical bone augmentation. Reviewed International journal

    @Hayashi K, @Kishida R, @Tsuchiya A, @Ishikawa K

    Bioenginnering   9   627   2022.3

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    DOI: https://doi.org/10.3389/fbioe.2022.825831

  • Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis. Reviewed International journal

    @Hayashi K, @Yanagisawa T, @Shimabukuro M, @Kishida R, @Ishikawa K

    Materials Today Bio   14   100247   2022.3

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    Language:Japanese  

    DOI: https://doi.org/10.1016/j.mtbio.2022.100247

  • Surface functionalization with copper endows carbonate apatite honeycomb scaffold with antibacterial, proangiogenic, and pro-osteogenic activities Reviewed International journal

    @Shimabukuro M, @Hayashi K, @Kishida R, @Tsuchiya A, @Ishikawa K

    Biomaterials Advances   135 ( 212751 )   2022.3

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  • Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects Reviewed International journal

    #Keigo Shibahara, @Koichiro Hayashi, @Yasuharu Nakashima, @Kunio Ishikawa

    Front Bioeng Biotechnol   2022.3

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    Language:English  

    DOI: 10.3389/fbioe.2022.825831

  • Fabrication and histological evaluation of porous carbonate apatite blocks using disodium hydrogen phosphate crystals as a porogen and phosphatization accelerator Reviewed International journal

    #Pery Freitas, @Ryo Kishida, @Koichiro Hayashi, @Akira Tsuchiya, @Masaya Shimabukuro, @Kunio Ishikawa

    J Biomed Mater Res: Part A   1278 - 1290   2022.2

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    DOI: 10.1002/jbm.a.37374

  • Fabrication of vaterite blocks from a calcium hydroxide compact. Reviewed International journal

    Ceramics International   48 ( 3 )   4153 - 4157   2022.2

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  • Feasibility study on surface morphology regulation of β-tricalcium phosphate bone graft for enhancing cellular response Reviewed International journal

    48 ( 9 )   13395 - 13399   2022.2

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  • Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks. Reviewed International journal

    #Elsheikh M, @Kishida R, @Hayashi K, @Tsuchiya A, @Shimabukuro M, @Ishikawa K:

    Regenerative Biomaterials   2022.2

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    DOI: https://doi.org/10.1093/rb/rbac010

  • Antibacterial Honeycomb Scaffolds for Achieving Infection Prevention and Bone Regeneration Reviewed International journal

    @Koichiro Hayashi, @Masaya Shimabukuro, @Kunio Ishikawa

    ACS Appl. Mater. Interfaces   ( 14 )   3762 - 3772   2022.1

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    DOI: https://doi.org/10.1021/acsami.1c20204

  • Antibacterial Honeycomb Scaffolds for Achieving Infection Prevention and Bone Regeneration

    Koichiro Hayashi, Masaya Shimabukuro, Kunio Ishikawa

    ACS Applied Materials & Interfaces   14 ( 3 )   3762 - 3772   2022.1

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    DOI: 10.1021/acsami.1c20204

  • Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute

    Naoyuki Fukuda, Kunio Ishikawa, Youji Miyamoto

    Ceramics International   48 ( 2 )   1796 - 1804   2022.1

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    DOI: 10.1016/j.ceramint.2021.09.260

  • Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute. Reviewed International journal

    @Fukuda N, @Ishikawa K, @Miyamoto Y:

    Ceramics International   48 ( 2 )   1796 - 1804   2022.1

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  • Effects of carbonate ions in phosphate solution on composition and nanoarchitecture of carbonate apatite fabricated through a dissolution–precipitation reaction Reviewed International journal

    48 ( 2 )   1796 - 1804   2022.1

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  • Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation. Reviewed International journal

    @Hayashi K, @Shimabukuro M, @Kishida R, @Tsuchiya A, @Ishikawa K

    Journal of Advanced Research   2022.1

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  • Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V. Reviewed

    @Sunarso, @Akira Tsuchiy, @Riki Toita, @Kanji Tsuru, @Kunio Ishikawa

    Materials Letters   304   130716 - 130716   2021.12

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    DOI: https://doi.org/10.1016/j.matlet.2021.130716

  • No-observed-effect level of silver phosphate in carbonate apatite artificial bone on initial bone regeneration. Reviewed International journal

    @Shimabukuro M,@ Hayashi K, @Kishida R, @Tsuchiya A, @Ishikawa K

    ACS Infectious Diseases   8 ( 1 )   159 - 169   2021.12

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  • Effects of the carbonate content in carbonate apatite on bone replacement Reviewed International journal

    #Deguchi K, @Nomura S, @Tsuchiya A, @Takahashi I, @Ishikawa K

    J Tissue Eng Regen Med   16 ( 2 )   200 - 206   2021.11

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    DOI: https://doi.org/10.1002/term.3270

  • Ennhancement of bone to polylactic acid plate bonding by carbonate apatite coating. Reviewed

    Ceramics International   47 ( 20 )   28348 - 28356   2021.10

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    DOI: https://doi.org/10.1016/j.ceramint.2021.06.252

  • Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading. Reviewed

    @Yoichiro Ogino, @Yasunori Ayukawa, @Noriko Tachikawa, @Masahiro Shimogishi, @Youji Miyamoto, @Keiko Kudoh, @Naoyuki Fukuda, @Kunio Ishikawa, @Kiyoshi Koyano

    Materials   14 ( 19 )   5760 - 5760   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ma14195760

  • Influence of pH and ion components in the liquid phase on the setting reaction of carbonate apatite granules. Reviewed

    @Akira Tsuchiya, #Pery Pinheiro Freitas, #Nozomi Nagashima, @Kunio Ishikawa

    Dent Mater J.   2021.10

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    DOI: 10.4012/dmj.2021-211

  • Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials. Reviewed

    Journal of Cellular Physiology   236 ( 9 )   6742 - 6753   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/jcp.30336

  • Effects of carbonate ions in phosphate solution on the fabrication of carbonate apatite through a dissolution–precipitation reaction

    2021.9

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    DOI: 10.1016/j.ceramint.2021.09.188

  • Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration. Reviewed

    @Koichiro Hayashi, @Masaya Shimabukuro, @Ryo Kishida, @Akira Tsuchiya, @Kunio Ishikawaa

    Materials Advances   2021.9

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    DOI: https://doi.org/10.1039/D1MA00698C

  • Honeycomb Scaffold-Guided Bone Reconstruction of Critical-Sized Defects in Rabbit Ulnar Shafts. Reviewed

    #Keigo Shibahara, @Koichiro Hayashi, @Yasuharu Nakashima, @Kunio Ishikawa

    ACS Appl. Bio Mater.   4 ( 9 )   6821 - 6831   2021.9

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    DOI: https://doi.org/10.1021/acsabm.1c00533

  • Fabrication of highly interconnected porous carbonate apatite blocks based on the setting reaction of calcium sulfate hemihydrate granules. Reviewed

    @Ryo Kishida, #Maab Elsheikh, @Koichiro Hayashi, @Akira Tsuchiya, @Kunio Ishikawa

    Ceramics International   47 ( 14 )   19856 - 19863   2021.7

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    DOI: https://doi.org/10.1016/j.ceramint.2021.03.324

  • Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment

    Harumi Tsutsumi, Yusuke Tsutsumi, Masaya Shimabukuro, Tomoyo Manaka, Peng Chen, Maki Ashida, Kunio Ishikawa, Hideki Katayama, Takao Hanawa

    Coatings   11 ( 7 )   798 - 798   2021.7

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    DOI: 10.3390/coatings11070798

  • Carbonate apatite artificial bone

    Kunio Ishikawa, Koichiro Hayashi

    Science and Technology of Advanced Materials   2021.7

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    DOI: 10.1080/14686996.2021.1947120

  • Impacts of channel direction on bone tissue engineering in 3D-printed carbonate apatite scaffolds

    Koichiro Hayashi, Nao Kato, Masaki Kato, Kunio Ishikawa

    Materials and Design   204   2021.6

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    DOI: 10.1016/j.matdes.2021.109686

  • Impacts of channel direction on bone tissue enginnering in 3D-printed carbonate apatite scaffolds Reviewed International journal

    @Hayashi K, @Kato N, @Kato M, @Ishikawa K

    Materials & Design   204   2021.6

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  • Enhancement of antibacterial property of titanium by two-step micro arc oxidation treatment. Reviewed

    @Masaya Shimabukuro, @Harumi Tsutumi, @Yusuke Tsutsumi, @Tomoyo Manaka, @Peng Chen, @Maki Ashida, @Kunio Ishikawa, @Hideki Katayama, @Takao Hanawa

    Dent Mater J   40 ( 3 )   592 - 598   2021.5

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    DOI: 10.4012/dmj.2020-188

  • In vitro investigation of the cell compatibility and antibacterial properties of titanium treated with calcium and ozone

    Masaaki Takechi, Megumi Takamoto, Yoshiaki Ninomiya, Shigehiro Ono, Kuniko Mizuta, Takayuki Nakagawa, Hideo Shigeishi, Kouji Ohta, Kunio Ishikawa, Kanji Tsuru

    Dental materials journal   40 ( 3 )   712 - 718   2021.5

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    DOI: 10.4012/dmj.2020-224

  • Honeycomb scaffolds capable of ectopic osteogenesis: Histological evaluation of osteoinduction mechanism. Reviewed

    @Koichiro Hayash, @Kunio Ishikawa

    Nano Select   1 - 19   2021.5

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    DOI: https://doi.org/10.1002/nano.202000283

  • Fibronectin adsorption on carbonate-containing hydroxyapatite. Reviewed

    @Yungting Wang, @Kanji Tsuru, @Kunio Ishikawa, @Taishi Yokoi, @Masakazu Kawashita

    Ceramics International   47 ( 8 )   11769 - 11776   2021.4

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    DOI: https://doi.org/10.1016/j.ceramint.2021.01.017

  • Duration of dentin tubule occlusion by the calcium phosphate precipitation method: An in vivo study in beagle dogs.

    Toshiyuki Suge, Kunio Ishikawa, Takashi Matsuo, Shigeyuki Ebisu

    Dental materials journal   2021.4

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    DOI: 10.4012/dmj.2020-372

  • Initial formation kinetics of calcium phosphate on titanium in Hanks’ solution characterized using XPS. Reviewed

    53 ( 2 )   185 - 193   2021.2

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    DOI: https://doi.org/10.1002/sia.6900

  • Reconstruction of critical-size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds. Reviewed

    #Yuta Sakemi, @Koichiro Hayashi, @Akira Tsuchiya, @Yasuharu Nakashima, @Kunio Ishikawa

    Journal of Biomedical Materials Research: Part A   1 - 10   2021.2

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    DOI: https://doi.org/10.1002/jbm.a.37157

  • Characterization of carbonate apatite derived from chicken bone and its in-vitro evaluation using MC3T3-E1 cells. Reviewed

    @Nguyen Xuan Thanh Tram, @Kunio Ishikawa, @Tran Hoang Minh, @David Benson, @Tsuru Kanji

    Materials Research Express   8 ( 2 )   2021.2

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    DOI: https://doi.org/10.1088/2053-1591/abe018

  • Honeycomb scaffolds fabricated using extrusion molding and sphere packing theory for bone regeneration. Reviewed

    @Koichiro Hayashi, @Kunio Ishikawa

    ACS Applied Bio Materials   4 ( 1 )   721 - 730   2020.12

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    DOI: https://doi.org/10.1021/acsabm.0c01279

  • Fabrication of three-dimensional interconnected porous blocks composed of robust carbonate apatite frameworks.

    @Tansza S. Putri, @Koichiro Hayashi, @Kunio Ishikawa

    Ceramics International   46 ( 12 )   20045 - 20049   2020.8

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    DOI: https://doi.org/10.1016/j.ceramint.2020.05.076

  • Effects of nanopores on the mechanical strength, osteoclastogenesis, and osteogenesis in honeycomb scaffolds. Reviewed

    @Koichiro Hayashi, @Kunio Ishikawa

    Journal of Materials Chemistry B   8   8536 - 8545   2020.8

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    DOI: https://doi.org/10.1039/D0TB01498B

  • Rapid osseointegration bestowed by carbonate apatite coating of rough titanium. Reviewed

    #Rui Shi, @Koichiro Hayashi, @Kunio Ishikawa

    Advanced Materials Interfaces   8   2000636   2020.8

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    DOI: 10.1002/admi.202000636

  • Titanium surface treatment by calcium modification with acid-etching promotes osteogenic activity and stability of dental implants. Reviewed

    @Yujiro Doe, @Hiroto Ida, @Masahiro Seiryu, @Toru Deguchi, @Nobuo Takeshita, @Satoshi Sasaki, @Shutaro Sasaki, @Daiki Irie, @Kanji Tsuru, @Kunio Ishikawa, @Teruko Takano-Yamamoto

    Materialia   12 ( 100801 )   2020.8

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    DOI: https://doi.org/10.1016/j.mtla.2020.100801

  • Fabrication of an interconnected porous β-tricalcium phosphate structure by polyacrylic acid-mediated setting reaction and sintering. Reviewed

    128 ( 8 )   555 - 559   2020.8

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    DOI: doi:10.2109/jcersj2.20059

  • Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties.

    112   110918 - 110918   2020.7

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    DOI: https://doi.org/10.1016/j.msec.2020.110918

  • Formation of 2D calcium hydroxyapatite on stainless steel modified with a TiN sublayer. Reviewed

    @Vilma Jonauske, @Rimantas Ramanauskas, @Rasa Platakyte, @Gediminas Niaura, @Lina Mikoliunaite, @Kunio Ishikawa, @Aivaras Kareiva

    Mendeleev Communications   30 ( 4 )   512 - 515   2020.7

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    DOI: https://doi.org/10.1016/j.mencom.2020.07.037

  • Effects of macropore size in carbonate apatite honeycomb scaffolds on bone regeneration.

    @Koichiro Hayashi, @Melvin L. Munar, @Kunio Ishikawa

    Materials Science & Engineering C   111   2020.6

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    DOI: https://doi.org/10.1016/j.msec.2020.110848

  • Zinc and chromium co-doped calcium hydroxyapatite: Sol-gel synthesis, characterization, behaviour in simulated body fluid and phase transformations.

    Stasys Tautkus, @Kunio Ishikawa, Rimantas Ramanauskas, Aivaras Kareiva

    Journal of Solid State Chemistry   284   2020.4

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    DOI: https://doi.org/10.1016/j.jssc.2020.121202

  • Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects Reviewed

    Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Keiko Kudoh, Naito Kurio, Kanji Tsuru, Kunio Ishikawa, Youji Miyamoto

    Journal of Biomedical Materials Research - Part A   108 ( 3 )   709 - 721   2020.3

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    DOI: 10.1002/jbm.a.36850

  • Fabrication and histological evaluation of a fully interconnected porous CO3Ap block formed by hydrate expansion of CaO granules. Reviewed

    #Keisuke Tanaka, @Akira Tsuchiya, @Yoichiro Ogino, @Kiyoshi Koyano, @Kunio Ishikawa

    ACS Appl. Bio Mater   3 ( 12 )   8872 - 8878   2020.3

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    DOI: https://doi.org/10.1021/acsabm.0c01176

  • Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes Effects of Composition on Bone Formation and Maturation Reviewed

    3 ( 3 )   1787 - 1795   2020.3

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    Material composition and porous structure are important factors in the formation and maturation of newly formed bone and replacement of materials by new bone. Conventional bone graft materials often lack suitability for bone generation because of the complexity of their macroporous structures, which can interfere with the penetration of cells related to bone remodeling and angiogenesis in the materials. In the present study, carbonate apatite (CO3Ap), hydroxyapatite (HAp), and β-tricalcium phosphate (TCP) honeycomb granules (HCGs) with uniformly sized macropores (∼115 μm) were fabricated. These HCG macropores were arranged in a regular fashion and penetrated straight into the granules. They were implanted into a rabbit femur defect for further evaluation. In the CO3Ap HCG implantation group, mature bone formed within CO3Ap HCG macropores by 4 weeks after grafting, and a large portion of CO3Ap HCGs was replaced by new bone at 12 weeks. By contrast, in the β-TCP HCG implantation group, new bone was not always formed in the regions after β-TCP HCG disappearance, and immature bone was present within β-TCP HCG macropores even after 12 weeks. HAp HCGs were not resorbed, and their macropores were filled with immature bone. The area of mature bone in the CO3Ap HCG implantation group was 3.3 and 1.6 times higher at 4 weeks and 2.2 and 1.7 times higher at 12 weeks compared with the HAp and β-TCP HCG implantation groups, respectively. Furthermore, the degrees of bone maturation for CO3Ap, HAp, and β-TCP HCGs were 100, 34, and 64% at 4 weeks, and 100, 54, and 69% at 12 weeks, respectively. Thus, the composition of the HCGs affected bone formation and maturation.

    DOI: 10.1021/acsabm.0c00060

  • Effects of surface roughening and calcite coating of titanium on cell growth and differentiation Reviewed

    Rui Shi, Koichiro Hayashi, L. T. Bang, Kunio Ishikawa

    Journal of Biomaterials Applications   34 ( 7 )   917 - 927   2020.2

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    DOI: 10.1177/0885328219883765

  • Sol-gel synthesis of calcium phosphate-based coatings - A review Reviewed

    Kunio Ishikawa, Aivaras Kareiva

    Chemija   31 ( 1 )   25 - 41   2020.2

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    DOI: 10.6001/chemija.v31i1.4169

  • Ozone-gas-mediated surface hydrophilization enhances the cell responses to titanium Reviewed

    Sunarso, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    Materials Letters   261   2020.2

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    DOI: 10.1016/j.matlet.2019.127168

  • Formation of calcium hydroxyapatite with high concentration of homogeneously distributed silver Reviewed

    Inga Grigoraviciute-Puroniene, Zivile Stankeviciute, Kunio Ishikawa, Aivaras Kareiva

    Microporous and Mesoporous Materials   293   2020.2

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    DOI: 10.1016/j.micromeso.2019.109806

  • Behavioural response of cells and bacteria on single and multiple doped Sr and Ag S53P4 sol-gel bioglass Reviewed

    Thet Thet Swe, Khairul Anuar Shariff, Hasmaliza Mohamad, Kunio Ishikawa, Koichiro Hayashi, Mohamad Hafizi Abu Bakar

    Ceramics International   2020.1

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    DOI: 10.1016/j.ceramint.2020.04.094

  • Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes Reviewed

    2020.1

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    In this review article the available results about application of sol–gel synthesis method for the preparation of different calcium phosphates and composite materials are summarized. The attention is paid to calcium phosphate-containing compounds which show the biological properties and could be used as potential phosphate bioceramics in medicine. It was demonstrated that the sol–gel synthesis method is a powerful tool for the synthesis of calcium hydroxyapatite and other phosphates, and different calcium phosphate-based composites at mild synthetic conditions resulted in high reproducibility, high phase purity, and desired morphology. Thus, the sol–gel synthesis method enables the researchers to develop biomaterials with superior features in terms of biomedical applications.

    DOI: 10.1007/s10971-020-05245-8

  • Enhanced osseointegration capability of poly(Ether ether ketone) via combined phosphate and calcium surface-functionalization Reviewed

    Sunarso, Akira Tsuchiya, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    International journal of molecular sciences   21 ( 1 )   2020.1

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    DOI: 10.3390/ijms21010198

  • Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement Reviewed

    108 ( 1 )   22 - 29   2020.1

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    Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0–600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20–600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules.

    DOI: 10.1002/jbm.b.34361

  • Cerium doping and cerium aluminium co-doping effects on the sol-gel processing of Y3Fe5O12 (YIG) Bulk and thin films Reviewed

    Olga Opuchovic, Mindaugas Andrulevicius, Sigitas Tamulevicius, Jean Luc Rehspringer, Aldona Beganskiene, Ramunas Skaudzius, Kunio Ishikawa, Aivaras Kareiva

    Solid State Sciences   99   2020.1

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    DOI: 10.1016/j.solidstatesciences.2019.106065

  • Biological responses of MC3T3-E1 on calcium carbonate coatings fabricated by hydrothermal reaction on titanium Reviewed

    Bang Le Thi, Rui Shi, Bui Duc Long, S. Ramesh, Shi Xingling, Yuki Sugiura, Kunio Ishikawa

    Biomedical Materials (Bristol)   15 ( 3 )   2020.1

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    DOI: 10.1088/1748-605X/ab6939

  • Application of low crystalline carbonate apatite granules in two-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation.

    @Takayuki Nakagawa, @Naoyuki Fukuda, @Shohei Kasugai, @Noriko Tachikawa, @Kiyoshi Koyano, @Yasuyuki Matsushita, @Masanori Sasaki, @Kunio Ishikawa, @Youji Miyamoto

    Journal of Periodontal & Implant Science   49 ( 6 )   382 - 396   2019.12

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    DOI: 10.5051/jpis.2019.49.6.382

  • Carbonate Apatite Micro-Honeycombed Blocks Generate Bone Marrow-Like Tissues as well as Bone Reviewed

    Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Advanced Biosystems   3 ( 12 )   2019.12

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    DOI: 10.1002/adbi.201900140

  • Fabrication and histological evaluation of porous carbonate apatite block from gypsum block containing spherical phenol resin as a porogen.

    #Yuta Sakemi, @Koichiro Hayashi, @Akira Tsuchiya, @Yasuharu Nakashima, @Kunio Ishikawa

    Materials   12 ( 23 )   2019.12

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    DOI: 10.3390/ma12233997

  • Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules.

    2019.11

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    DOI: 10.1002/jbm.a.36842

  • Transition metal substitution effects in sol-gel derived Mg3-xMx/Al1 (M = Mn, Co, Ni, Cu, Zn) layered double hydroxides Reviewed

    L. Valeikiene, R. Paitian, I. Grigoraviciute-Puroniene, K. Ishikawa, A. Kareiva

    Materials Chemistry and Physics   237   2019.11

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    DOI: 10.1016/j.matchemphys.2019.121863

  • Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation.

    @Takamitsu Mano, @Kazuya Akita, @Naoyuki Fukuda, @Kumiko Kamada, @Naito Kurio, @Kunio Ishikawa, @Youji Miyamoto

    Journal of Biomedical Materials Research: Part B - Applied Biomaterials   2019.10

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    DOI: 10.1002/jbm.b.34492

  • PO4 adsorption on the calcite surface modulates calcite formation and crystal size Reviewed

    Yuki Sugiura, Kunio Ishikawa, Kazuo Onuma, Yoji Makita

    American Mineralogist   104 ( 10 )   1381 - 1388   2019.10

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    DOI: 10.2138/am-2019-7015

  • Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration effects of composition on biological responses Reviewed

    4   2019.9

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    Synthetic scaffolds exhibiting bone repair ability equal to that of autogenous bone are required in the fields of orthopedics and dentistry. A suitable synthetic bone graft substitute should induce osteogenic differentiation of mesenchymal stem cells, osteogenesis, and angiogenesis. In this study, three types of honeycomb blocks (HCBs), composed of hydroxyapatite (HAp), β-tricalcium phosphate (TCP), and carbonate apatite (CO3Ap), were fabricated, and the effects of HCB composition on bone formation and maturation were investigated. The HC structure was selected to promote cell penetration and tissue ingrowth. HAp and β-TCP HCBs were fabricated by extrusion molding followed by sintering. The CO3Ap HCBs were fabricated by extrusion molding followed by sintering and dissolution-precipitation reactions. These HCBs had similar macroporous structures: all harbored uniformly distributed macropores (∼160 ​μm) that were regularly arrayed and penetrated the blocks unidirectionally. Moreover, the volumes of macropores were nearly equal (∼0.15 ​cm3/g). The compressive strengths of CO3Ap, HAp, and β-TCP HCBs were 22.8 ​± ​3.5, 34.2 ​± ​3.3, and 24.4 ​± ​2.4 ​MPa, respectively. Owing to the honeycomb-type macroporous structure, the compressive strengths of these HCBs were higher than those of commercial scaffolds with intricate three-dimensional or unidirectional macroporous structure. Notably, bone maturation was markedly faster in CO3Ap HCB grafting than in β-TCP and HAp HCB grafting, and the mature bone area percentages for CO3Ap HCBs at postsurgery weeks 4 and 12 were 14.3- and 4.3-fold higher and 7.5- and 1.4-fold higher than those for HAp and β-TCP HCBs, respectively. The differences in bone maturation and formation were probably caused by the disparity in concentrations of calcium ions surrounding the HCBs, which were dictated by the inherent material resorption behavior and mechanism; generally, CO3Ap is resorbed only by osteoclastic resorption, HAp is not resorbed, and β-TCP is rapidly dissolved even in the absence of osteoclasts. Besides the composition, the microporous structure of HC struts, inevitably generated during the formation of HCBs of various compositions, may contribute to the differences in bone maturation and formation.

    DOI: 10.1016/j.mtbio.2019.100031

  • Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion.

    101   228 - 231   2019.8

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    DOI: 10.1016/j.msec.2019.03.106

  • Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration Reviewed

    Koichiro Hayashi, Melvin L. Munar, Kunio Ishikawa

    Ceramics International   45 ( 12 )   15429 - 15434   2019.8

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    DOI: 10.1016/j.ceramint.2019.05.042

  • A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite Reviewed

    Inga Grigoraviciute-Puroniene, Yuhei Tanaka, Visata Vegelyte, Yuko Nishimoto, Kunio Ishikawa, Aivaras Kareiva

    Ceramics International   45 ( 12 )   15620 - 15623   2019.8

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    DOI: 10.1016/j.ceramint.2019.05.072

  • A novel synthetic approach for the calcium hydroxyapatite from the food products Reviewed

    Inga Grigoraviciute-Puroniene, Aleksej Zarkov, Kanji Tsuru, Kunio Ishikawa, Aivaras Kareiva

    Journal of Sol-Gel Science and Technology   91 ( 1 )   63 - 71   2019.7

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    DOI: 10.1007/s10971-019-05020-4

  • Controllable synthesis of tricalcium phosphate (TCP) polymorphs by wet precipitation: Effect of washing procedure.

    @Lauryna Sinusaite, @Inga Grigoraviciute-Puroniene, @Anton Popov, @Kunio Ishikawa, @Aivaras Kareiva, @Aleksej Zarkov

    Ceramics International   45 ( 9 )   12423 - 12428   2019.6

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    DOI: 10.1016/j.ceramint.2019.03.174

  • Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: First-in-human clinical trial.

    @Keiko Kudoh, @Naoyuki Fukuda, @Shohei Kasugai, @Noriko Tachikawa, @Kiyoshi Koyano, @Yasuyuki Matsushita, @Yoichiro Ogino, @Kunio Ishikawa, @Youji Miyamoto

    Journal of Oral and Maxillofacial Surgery   77 ( 5 )   985 - e1-985.e11   2019.5

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    DOI: 10.1016/j.joms.2018.11.026

  • Fabrication of carbonate apatite honeycomb and its tissue response Reviewed

    Kunio Ishikawa, Melvin L. Munar, Kanji Tsuru, Youji Miyamoto

    Journal of Biomedical Materials Research - Part A   107 ( 5 )   1014 - 1020   2019.5

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    DOI: 10.1002/jbm.a.36640

  • Characterization of Sol-Gel derived calcium hydroxyapatite coatings fabricated on patterned rough stainless steel surface Reviewed

    Vilma Jonauske, Sandra Stanionyte, Shih Wen Chen, Aleksej Zarkov, Remigijus Juskenas, Algirdas Selskis, Tadas Matijosius, Thomas C.K. Yang, Kunio Ishikawa, Rimantas Ramanauskas, Aivaras Kareiva

    Coatings   9 ( 5 )   2019.5

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    DOI: 10.3390/COATINGS9050334

  • Fabrication and evaluation of interconnected porous carbonate apatite from alpha tricalcium phosphate spheres.

    @Kunio Ishikawa, @Tya Indah Arifta, @Koichiro Hayashi, @Kanji Tsuru

    Journal of Biomedical Materials Research: Part B - Applied Biomaterials.   107 ( 2 )   269 - 277   2019.2

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    DOI: 10.1002/jbm.b.34117

  • Biocompatibility of hydrophilicity improved apatite cement Reviewed

    Ira Artilia, Kanji Tsuru, Kunio Ishikawa

    Journal of Biomimetics, Biomaterials and Biomedical Engineering   43   124 - 129   2019.1

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    DOI: 10.4028/www.scientific.net/JBBBE.43.124

  • Vertical bone augmentation using carbonate apatite bone substitute

    Kunio Ishikawa, Koichiro Hayashi, Akira Tsuchiya, Ryo Kishida

    42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence Society for Biomaterials Annual Meeting and Exposition 2019 The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting   2019.1

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  • Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone) Reviewed

    Naoyuki Fukuda, Akira Tsuchiya, Sunarso, Riki Toita, Kanji Tsuru, Yoshihide Mori, Kunio Ishikawa

    Colloids and Surfaces B: Biointerfaces   173   36 - 42   2019.1

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    DOI: 10.1016/j.colsurfb.2018.09.032

  • Identification of initial colonizing bacteria in dental plaques from young adults using full-length 16S rRNA gene sequencing Reviewed

    Yukari Ihara, Toru Takeshita, Shinya Kageyama, Rie Matsumi, Mikari Asakawa, Yukie Shibata, Yuki Sugiura, Kunio Ishikawa, Ichiro Takahashi, Yoshihisa Yamashita

    mSystems   4 ( 5 )   2019.1

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    DOI: 10.1128/mSystems.00360-19

  • Effect of silver on the apatite formation of bioactive silicate glass Reviewed

    T. T. Swe, K. A. Shariff, A. F.M. Noor, K. Ishikawa, H. Mohamad

    6th International Conference on Recent Advances in Materials, Minerals and Environment, RAMM 2018 Materials Today: Proceedings   17   884 - 888   2019.1

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    DOI: 10.1016/j.matpr.2019.06.385

  • Effect of aging time on the crystal structure of new quaternary silicate gel-glasses Reviewed

    Thet Thet Swe, Khairul Anuar Shariff, Ahmad Fauzi Mohd Noor, Kunio Ishikawa, Hasmaliza Mohamad

    2017 Conference on Biomedical and Advanced Materials, Bio-CAM 2017 Materials Today: Proceedings   16   1668 - 1672   2019.1

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    DOI: 10.1016/j.matpr.2019.06.033

  • Carbonate apatite bone replacement Learn from the bone Reviewed

    Kunio Ishikawa

    Journal of the Ceramic Society of Japan   127 ( 9 )   595 - 601   2019.1

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    DOI: 10.2109/jcersj2.19042

  • Fabrication of calcite-coated rough-surface titanium using calcium nitrate.

    #Rui Shi, @Yuki Sugiura, @Kanji Tsuru, @Kunio Ishikawa

    Surface and Coatings Technology   356   72 - 79   2018.12

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    DOI: 10.1016/j.surfcoat.2018.09.050

  • Effect of setting atmosphere on apatite cement resorption An in vitro and in vivo study Reviewed

    Arief Cahyanto, Kanji Tsuru, Kunio Ishikawa

    Journal of the Mechanical Behavior of Biomedical Materials   88   463 - 469   2018.12

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    DOI: 10.1016/j.jmbbm.2018.08.021

  • Fabrication of pure octacalcium phosphate blocks from dicalcium hydrogen phosphate dihydrate blocks via a dissolution-precipitation reaction in a basic solution.

    @Yuki Sugiura, @Kunio Ishikawa

    Materials Letters   293   143 - 146   2018.12

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    DOI: 10.1016/j.matlet.2018.12.093

  • Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia.

    Scientific Reports   8 ( 1 )   16887   2018.12

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    DOI: 10.1038/s41598-018-35313-7

  • Fabrication of carbonate apatite blocks from octacalcium phosphate blocks through different phase conversion mode depending on carbonate concentration.

    @Yuki Sugiura, @Kunio Ishikawa

    Journal of Solid State Chemistry   267   85 - 91   2018.11

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    DOI: 10.1016/j.jssc.2018.08.008

  • Fabrication of apatite-coated gypsum granules and histological evaluation using rabbits Reviewed

    Akira Tsuchiya, Marino Sato, Ichiro Takahashi, Kunio Ishikawa

    Ceramics International   44 ( 16 )   20330 - 20336   2018.11

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    DOI: 10.1016/j.ceramint.2018.08.021

  • Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution.

    33 ( 5 )   630 - 636   2018.10

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    DOI: 10.1177/0885328218808015

  • Synthesis and Characterization of Bioactive Quaternary Silicate Gel-glasses Reviewed

    T. T. Swe, H. Mohamad, K. A. Shariff, A. F.M. Noor, K. Ishikawa, A. A. Thant

    Regional Conference on Materials and ASEAN Microscopy Conference 2017, RCM and AMC 2017 Journal of Physics: Conference Series   1082 ( 1 )   2018.10

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    DOI: 10.1088/1742-6596/1082/1/012070

  • Micro-CT evaluation on osteoconductivity of DCPD-coated β-TCP granule using experimental rats Reviewed

    1082 ( 1 )   2018.10

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    β-tricalcium phosphate (β-TCP) bone substitutes have been widely used because of its excellent tissue response and good osteoconductivity. However, recent study reported that the osteoconductivity of β-TCP could be enhanced by treating β-TCP surfaces with saturated acidic calcium phosphate solution. In this study, the osteoconductivity of treated β-TCP granule were evaluated using micro-computed tomography (micro-CT) scan technique. The granule specimens were obtained by exposing β-TCP granules with saturated acidic calcium phosphate solution for 10, 30 and 60 mins, respectively. Then, critical bone defect size with dimension of 9 mm were made at rat calvarial, and the defect was reconstructed with 10, 30 and 60 mins treated β-TCP granules and β-TCP granules without treatment as a control. After 2 and 4 weeks implantation, the specimens with the surrounding bone tissue were taken out and examined using micro-CT machine. Based on the cross section of micro-CT images, new bone formations were observed from the edge of the defect towards the center of the bone defect area in all specimens. At 2 weeks, new bone formations were observed for 10 min and 30 min treated β-TCP granules when compared with other specimens. The 30 min treated β-TCP granules showed faster new bone formation rate after 4 weeks implantation. It can be concluded that 30 min treated β-TCP granules revealed the highest osteoconductivity in comparison to the other specimens.

    DOI: 10.1088/1742-6596/1082/1/012069

  • Physical and histological comparison of hydroxyapatite, carbonate apatite, and β-tricalcium phosphate bone substitutes.

    11 ( 10 )   1993   2018.10

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    DOI: 10.3390/ma11101993

  • Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor.

    @Yuki Sugiura, @Melvin L Munar, @Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine   29 ( 10 )   151 - 158   2018.9

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    DOI: 10.1007/s10856-018-6162-1

  • Compositional and histological comparison of carbonate apatite fabricated by dissolution-precipitation reaction and Bio-Oss®.

    29   121 - 121   2018.8

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    Carbonate apatite (CO3Ap) is an inorganic component of bone. This study aimed to compare the composition and tissue response to of CO3Ap (CO3Ap-DP) fabricated by the dissolution–precipitation reaction using calcite as a precursor and Bio-Oss®, which is widely used in orthopedic and dental fields as a synthetic bone substitute. X-ray diffraction and Fourier transform infrared results showed that CO3Ap-DP and Bio-Oss® were both B-type carbonate apatite with low crystallinity. The average sizes of CO3Ap-DP and Bio-Oss® granules were 450 ± 58 and 667 ± 168μ m, respectively, and their carbonate contents were 12.1 ± 0.6 and 5.6 ± 0.1 wt%, respectively. CO3Ap-DP had a larger amount of CO3 than Bio-Oss® but higher crystallinity than Bio-Oss®. When a bone defect made at the femur of rabbits was reconstructed with CO3Ap-DP and Bio-Oss®, CO3Ap-DP granules were partially replaced with bone, whereas Bio-Oss® remained at 8 weeks after implantation. CO3Ap-DP granules elicited a significantly larger amount of new bone formation at the cortical bone portion than Bio-Oss® at 4 weeks after the implantation. The results obtained in the present study demonstrated that CO3Ap-DP and Bio-Oss® showed different behavior even though they were both classified as CO3Ap. The CO3 content in CO3Ap played a more important role than the crystallinity of CO3Ap for replacement to bone and high osteoconductivity.

    DOI: 10.1007/s10856-018-6129-2

  • In Vivo stability evaluation of Mg substituted low crystallinity β-tricalcium phosphate blocks fabricated through dissolution–precipitation reaction for fast bone regeneration.

    13 ( 6 )   2018.8

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    DOI: 10.1088/1748-605X/aad385

  • Feasibility evaluation of low-crystallinity β-tricalcium phosphate blocks as a bone substitute fabricated by a dissolution–precipitation reaction from α-tricalcium phosphate blocks.

    33 ( 2 )   259 - 270   2018.8

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    Although sintered β-tricalcium phosphate blocks have been used clinically as artificial bone substitutes, the crystallinity of β-tricalcium phosphate, which might dominate biocompatibility, is extremely high. The objective of this study is to evaluate the feasibility of fabricating low-crystallinity β-tricalcium phosphate blocks, which are expected to exhibit good biocompatibility via a dissolution-precipitation reaction of α-tricalcium phosphate blocks as a precursor under hydrothermal conditions at 200°C for 24 h. Although β-tricalcium phosphate is a metastable phase, the presence of Mg2+ in the reaction solution inhibits the formation of its corresponding stable phase and induces β-tricalcium phosphate formation under acidic conditions. It was found that low-crystallinity β-tricalcium phosphate blocks could be fabricated from α-tricalcium phosphate blocks immersed in 1.0 mol/L MgCl2 + 0.1 mol/L NaH2PO4 solution while maintaining the shape of the α-tricalcium phosphate blocks. The crystallite size of the fabricated β-tricalcium phosphate blocks was 42 nm, which was substantially smaller than that of the sintered β-tricalcium phosphate blocks. When the fabricated β-tricalcium phosphate blocks were implanted into bone defects in rabbit femurs, they exhibited excellent tissue responses. In particular, the initial osteoconductivity (two and four weeks) was substantially greater than that of sintered β-tricalcium phosphate blocks.

    DOI: 10.1177/0885328218788255

  • Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering.

    @Masako Fujioka-Kobayashia, @Kanji Tsuru, @Hirokazu Nagai, @Kenji Fujisawa, @Takaharu Kudou, @Go Ohe, @Kunio Ishikawa, @Youji Miyamoto

    Journal of Tissue Engineering and Regenerative Medicine   12 ( 10 )   2077 - 2087   2018.7

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    DOI: 10.1002/term.2742

  • Effect of calcium and phosphate on compositional conversion from dicalcium hydrogen phosphate dihydrate blocks to octacalcium phosphate blocks Reviewed

    Yuki Sugiura, Kunio Ishikawa

    Crystals   8 ( 5 )   2018.5

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    DOI: 10.3390/cryst8050222

  • Effect of Ca and PO4 on compositional conversion from dicalcium hydrogen phosphate dihydrate blocks to octacalcium phosphate blocks.

    @Yuki Sugiura, @Kunio Ishikawa

    Crystals   8 ( 5 )   222 - 222   2018.5

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    DOI: https://doi.org/10.3390/cryst8050222

  • Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration Reviewed

    Sunarso, Akira Tsuchiya, Naoyuki Fukuda, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    Journal of Biomaterials Science, Polymer Edition   1 - 14   2018.4

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    DOI: 10.1080/09205063.2018.1461448

  • Fluoride activity of antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries Reviewed

    Toshiyuki Suge, Shingo Shibata, Kunio Ishikawa, Takashi Matsuo

    American Journal of Dentistry   31 ( 2 )   103 - 106   2018.4

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  • Fabrication of interconnected porous β-tricalcium phosphate (β-TCP) based on a setting reaction of β-TCP granules with HNO3 followed by heat treatment Reviewed

    106 ( 3 )   797 - 804   2018.3

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    β-Tricalcium phosphate [β-TCP] is the typical bone substitute due to its excellent osteoconductivity and bioresorbability. One of the keys to improve its potential as bone substitute is to introduce porous structure and its regulation. In this study, interconnected porous β-TCP blocks were fabricated through a setting reaction of β-TCP granules and subsequent heat treatment. First, β-TCP granules were mixed with HNO3. Upon mixing, β-TCP granules were bridged with dicalcium phosphate dihydrate [DCPD: CaHPO4·2H2O] containing Ca(NO3)2. Then, the DCPD-bridged β-TCP was heated at 1100°C. During the heating process, DCPD containing Ca(NO3)2 transformed into β-TCP and bonded with β-TCP granules. As a result, an interconnected porous β-TCP block formed. The diametral tensile strength and porosity of the interconnected porous β-TCP block fabricated from 200–300-μm β-TCP granules and 5 N HNO3 and then heated at 1,100°C were 1.4 ± 0.2 MPa and 57% ± 2%, respectively.

    DOI: 10.1002/jbm.a.36285

  • Fabrication of octacalcium phosphate foam through phase conversion and its histological evaluation Reviewed

    Yuki Sugiura, Melvin L. Munar, Kunio Ishikawa

    Materials Letters   212   28 - 31   2018.2

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    DOI: 10.1016/j.matlet.2017.10.051

  • Fabrication of self-setting β-tricalcium phosphate granular cement Reviewed

    106 ( 2 )   800 - 807   2018.2

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    Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction.

    DOI: 10.1002/jbm.b.33891

  • Fabrication of interconnected porous calcium-deficient hydroxyapatite using the setting reaction of α tricalcium phosphate spherical granules Reviewed

    43 ( 14 )   11149 - 11155   2017.10

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    Interconnected porous calcium-deficient hydroxyapatite (cdHAp) blocks may be an ideal biomaterial to repair bone defects because of their greater similarity to human bone than that of sintered hydroxyapatite (HAp) with respect to calcium content and crystallinity. In particular, the interconnected pores in cdHAp may provide pathways for cell migration and tissue ingrowth. In this study, the feasibility of fabricating interconnected porous cdHAp blocks through the setting reaction of alpha-tricalcium phosphate (αTCP) spherical granules was investigated. It was found that regulation of cdHAp formation was important to fabricate interconnected porous cdHAp blocks. That is, cdHAp needed to precipitate preferentially at the contacting areas between αTCP spherical granules. Exposure of αTCP spherical granules to steam under appropriate pressure was effective for this purpose. When αTCP spherical granules were immersed in water at 100 °C, the setting reaction resulted in dense cdHAp blocks because of the free crystal growth of cdHAp in water. Therefore, steam was used to localize the water at the contacting areas between αTCP spherical granules, which was driven by the surface tension of the water. Without an applied load, no setting reaction was observed when αTCP spherical granules were exposed to steam at 100 °C for 12 h. In contrast, under a load of 20 MPa, cdHAp precipitated to bridge spherical granules, providing an interconnected porous cdHAp block. The porosity and diametral tensile strength of this block were approximately 63% and 1.5 MPa, respectively.

    DOI: 10.1016/j.ceramint.2017.05.162

  • A novel wet polymeric precipitation synthesis method for monophasic β-TCP Reviewed

    28 ( 9 )   2325 - 2331   2017.9

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    β-Tricalcium phosphate (β-Ca3(PO4)2, β-TCP) powders were synthesized using wet polymeric precipitation method for the first time to our best knowledge. The results of X-ray diffraction analysis showed the formation of almost single a Ca-deficient hydroxyapatite (CDHA) phase of a poor crystallinity already at room temperature. With continuously increasing the calcination temperature up to 800 °C the crystalline β-TCP was obtained as the main phase. It was demonstrated that infrared spectroscopy is very effective method to characterize the formation of β-Ca3(PO4)2. The SEM results showed that β-Ca3(PO4)2 solids were homogeneous having a small particle size distribution. The β-TCP powders consisted of spherical particles varying in size from 100 to 300 nm. Fabricated β-TCP specimens were placed to the bones of the rats and maintained for 1–2 months. The histological properties of these samples will be also investigated.

    DOI: 10.1016/j.apt.2017.06.014

  • “Fabrication of arbitrarily shaped carbonate apatite foam based on the interlocking process of dicalcium hydrogen phosphate dihydrate” Reviewed

    28 ( 8 )   2017.8

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    Carbonate apatite (CO3Ap) foam with an interconnected porous structure is highly attractive as a scaffold for bone replacement. In this study, arbitrarily shaped CO3Ap foam was formed from α-tricalcium phosphate (α-TCP) foam granules via a two-step process involving treatment with acidic calcium phosphate solution followed by hydrothermal treatment with NaHCO3. The treatment with acidic calcium phosphate solution, which is key to fabricating arbitrarily shaped CO3Ap foam, enables dicalcium hydrogen phosphate dihydrate (DCPD) crystals to form on the α-TCP foam granules. The generated DCPD crystals cause the α-TCP granules to interlock with each other, inducing an α-TCP/DCPD foam. The interlocking structure containing DCPD crystals can survive hydrothermal treatment with NaHCO3. The arbitrarily shaped CO3Ap foam was fabricated from the α-TCP/DCPD foam via hydrothermal treatment at 200 °C for 24 h in the presence of a large amount of NaHCO3.

    DOI: 10.1007/s10856-017-5937-0

  • Nanoporous biomaterials for uremic toxin adsorption in artificial kidney systems A review Reviewed

    Wee Keat Cheah, Kunio Ishikawa, Radzali Othman, Fei Yee Yeoh

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   105 ( 5 )   1232 - 1240   2017.7

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    DOI: 10.1002/jbm.b.33475

  • Evaluation of carbonate apatite blocks fabricated from dicalcium phosphate dihydrate blocks for reconstruction of rabbit femoral and tibial defects Reviewed

    Masayuki Kanazawa, Kanji Tsuru, Naoyuki Fukuda, Yuta Sakemi, Yasuharu Nakashima, Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine   28 ( 6 )   2017.6

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    DOI: 10.1007/s10856-017-5896-5

  • Fabrication of dicalcium phosphate dihydrate-coated β-TCP granules and evaluation of their osteoconductivity using experimental rats Reviewed

    75   1411 - 1419   2017.6

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    β-Tricalcium phosphate (β-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. In this study, osteoconductivity of β-TCP bone substitute was enhanced without using growth factors or cells. Dicalcium phosphate dihydrate (DCPD), which is known to possess the highest solubility among calcium phosphates, was coated on β-TCP granules by exposing their surface with acidic calcium phosphate solution. The amount of coated DCPD was regulated by changing the reaction time between β-TCP granules and acidic calcium phosphate solution. Histomorphometry analysis obtained from histological results revealed that the approximately 10 mol% DCPD-coated β-TCP granules showed the largest new bone formation compared to DCPD-free β-TCP granules, approximately 2.5 mol% DCPD-coated β-TCP granules, or approximately 27 mol% DCPD-coated β-TCP granules after 2 and 4 weeks of implantation. Based on this finding, we demonstrate that the osteoconductivity of β-TCP granules could be improved by coating their surface with an appropriate amount of DCPD.

    DOI: 10.1016/j.msec.2017.03.004

  • Fabrication of calcite blocks from gypsum blocks by compositional transformation based on dissolution–precipitation reactions in sodium carbonate solution Reviewed

    72   389 - 393   2017.3

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    Calcium carbonate (CaCO3) has been used as a bone substitute, and is a precursor for carbonate apatite, which is also a promising bone substitute. However, limited studies have been reported on the fabrication of artificial calcite blocks. In the present study, cylindrical calcite blocks (ϕ6 × 3 mm) were fabricated by compositional transformation based on dissolution–precipitation reactions using different calcium sulfate blocks as a precursor. In the dissolution–precipitation reactions, both CaSO4·2H2O and CaSO4 transformed into calcite, a polymorph of CaCO3, while maintaining their macroscopic structure when immersed in 1 mol/L Na2CO3 solution at 80 °C for 1 week. The diametral tensile strengths of the calcite blocks formed using CaSO4·2H2O and CaSO4 were 1.0 ± 0.3 and 2.3 ± 0.7 MPa, respectively. The fabrication of calcite blocks using CaSO4·2H2O and CaSO4 proposed in this investigation may be a useful method to produce calcite blocks because of the self-setting ability and high temperature stability of gypsum precursors.

    DOI: 10.1016/j.msec.2016.11.093

  • Fabrication of carbonate apatite block through a dissolution-precipitation reaction using calcium hydrogen phosphate dihydrate block as a precursor Reviewed

    Kanji Tsuru, Ayami Yoshimoto, Masayuki Kanazawa, Yuki Sugiura, Yasuharu Nakashima, Kunio Ishikawa

    Materials   10 ( 4 )   2017.3

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    DOI: 10.3390/ma10040374

  • Effect of citric acid on setting reaction and tissue response to β-TCP granular cement Reviewed

    12 ( 1 )   2017.2

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    We recently reported that when an acidic calcium phosphate solution is mixed with β-tricalcium phosphate (β-TCP) granules, the resulting dicalcium phosphate dihydrate (DCPD) crystals form bridges between the β-TCP granules, creating a set interconnected porous structure in approximately 1 min. Although this self-setting β-TCP granular cement (β-TCPGC) is useful for clinical applications, the short setting time is a key drawback for handling. In this study, the setting time of β-TCPGC was adjusted with the addition of citric acid, which is a known inhibiter of DCPD crystal growth. As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. Four weeks after implantation, no inflammatory reaction and approximately 20% new bone formation were observed, regardless of the presence or absence of citric acid in the liquid phase of β-TCPGC. We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times.

    DOI: 10.1088/1748-605X/aa5aea

  • Development of carbonate apatite as artificial bone substitute Reviewed

    Kunio Ishikawa

    Japanese Magazine of Mineralogical and Petrological Sciences   46 ( 1 )   42 - 46   2017

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    DOI: 10.2465/gkk.161217

  • Preventive effects of a phospholipid polymer coating on PMMA on biofilm formation by oral streptococci Reviewed

    Yukie Shibata, Yoshihisa Yamashita, Kanji Tsuru, Kazuhiko Ishihara, Kyoko Fukazawa, Kunio Ishikawa

    Applied Surface Science   390   602 - 607   2016.12

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    DOI: 10.1016/j.apsusc.2016.08.108

  • Immobilization of calcium and phosphate ions improves the osteoconductivity of titanium implants. Reviewed International journal

    Sunarso, Riki Toita, Kanji Tsuru, Ishikawa Kunio

    Mater Sci Eng C   68   291 - 298   2016.11

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    DOI: org/10.1016/j.msec.2016.05.090

  • Fabrication of carbonate apatite pseudomorph from highly soluble acidic calcium phosphate salts through carbonation. Reviewed International journal

    Yuki Sugiura, Kanji Tsuru, Ishikawa Kunio

    J Ceram Soc Jpn   124 ( 8 )   827 - 832   2016.8

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    DOI: 10.2109/jcersj2.16046

  • A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses. Reviewed International journal

    Sunarso, Riki Toita, Kanji Tsuru, Ishikawa Kunio

    J Mater Sci: Mater Med   68   291 - 298   2016.8

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    DOI: 10.1007/s10856-016-5741-2

  • Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement. Reviewed International journal

    30 ( 6 )   838 - 845   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0885328215601939

  • Effects of acidic calcium phosphate concentration on mechanical strength of porous calcite fabricated by bridging with dicalcium phosphate dihydrate. Reviewed International journal

    Koga Noriko, Ishikawa Kunio, Kanji Tsuru, Ichiro Takahashi

    Ceram Int   42 ( 7 )   7912 - 7917   2016.5

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    DOI: org/10.1016/j.ceramint.2015.12.017

  • Fabrication of interconnected porous calcite by bridging calcite granules with dicalcium phosphate dihydrate and their histological evaluation. Reviewed International journal

    Ishikawa Kunio, Koga Noriko, Kanji Tsuru, Ichiro Takahashi

    J Biomed Mater Res: Part A   104 ( 3 )   652 - 658   2016.5

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    DOI: 10.1002/jbm.a.35604

  • Effects of apatite cement containing atelocollagen on attachment to, and proliferation and differentiation of MC3T3-E1 osteoblastic cells. Reviewed International journal

    Masaaki Takechi, Yoshiaki Ninomiya, Kouji Ohta, Misato Tada, Kazuki Sasaki, Mohammad Zeshaan Rahman, Akira Ohta, Kanji Tsuru, Ishikawa Kunio

    Materials   9 ( 4 )   283 - 283   2016.4

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    DOI: 10.3390/ma9040283

  • Partial oxidation of TiN coating by hydrothermal treatment and ozone treatment to improve its osteoconductivity Reviewed International journal

    Shi Xingling, Xu L, Le Bang Thi, Zhou G, Zheng C, Kanji Tsuru, Ishikawa Kunio

    Materials Science and Engineering: C   59   542 - 548   2016.2

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    DOI: 10.1016/j.msec.2015.10.024

  • Fabrication of carbonate apatite foam based on the setting reaction of α-tricalcium phosphate foam granules. Reviewed International journal

    42   204 - 210   2016.1

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    DOI: org/10.1016/j.ceramint.2015.08.081

  • Phase transformation of biphasic granules of gypsum and carbonated apatite at low temperatures. Reviewed International journal

    Adv Mater Res   1133   50 - 54   2016.1

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    DOI: 10.4028/www.scientific.net/AMR.1133.50

  • Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate. Reviewed International journal

    41 ( 10 )   13525 - 13531   2015.12

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    DOI: 10.1016/j.ceramint.2015.07.146

  • Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions. Reviewed International journal

    Riki Toita, Sunarso, Ahmed Nafis Rashid, Kanji Tsuru, Ishikawa Kunio

    J Mater Chem B   3 ( 44 )   8738 - 8746   2015.10

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    DOI: 10.1039/C5TB01679G

  • Effects of humidity on calcite block fabrication using calcium hydroxide compact. Reviewed International journal

    Noriko Koga, Kanji Tsuru, Ichiro Takahashi, Ishikawa Kunio

    Ceram Int   41 ( 8 )   9482 - 9487   2015.9

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  • Effects of the method of apatite seed crystals addition on setting reaction of α-tricalcium phosphate based apatite cement. Reviewed International journal

    26   244 - 451   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10856-015-5570-8

  • Effect of calcium-ozone treatment on chemical and biological properties of polyethylene terephthalate. Reviewed International journal

    Rashid RN, Tsuru Kanji, Ishikawa Kunio

    J Biomed Mater Res: Part B   3   853 - 860   2015.8

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  • Fabrication of β-TCP foam: effects of magnesium oxide as phase stabilizer on its properties. Reviewed International journal

    41   14245 - 14250   2015.7

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  • Histological comparison in rats between carbonate apatite fabricated from gypsum and sintered hydroxyapatite on bone remodeling. Reviewed International journal

    Yasunori Ayukawa, Yumiko Suzuki, Takamori Y, Atsuta I, Nakamura H, Sawase T, Koyano K, Hara Y., Ishikawa Kunio, Kanji Tsuru

    BioMed Res Int   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2015/579541

  • Fabrication of strongly attached hydroxyapatite coating on titanium by hydrothermal treatment of Ti-Zn-PO4 coated titanium in CaCl2 solution. Reviewed International journal

    ALIREZA VALANEZHAD, Kanji Tsuru, Ishikawa Kunio

    J Mater Sci: Mater Med   26 ( 7 )   5548 - 5557   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10856-015-5548-6

  • Fabrication of bone cement that fully transforms to carbonate apatite. Reviewed International journal

    Cahyanto A, Maruta M, Kanji Tsuru, Matsuya S, Ishikawa Kunio

    Dent Mater J   34 ( 3 )   394 - 401   2015.6

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  • Hydrothermal treatment for TiN as abrasion resistant dental implant coating and its fibroblast response. Reviewed International journal

    Shi Xing Ling, Xu L, MUNAR MELVIN DE LEON, Ishikawa Kunio

    Materials Science and Engineering: C   49   1 - 6   2015.4

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    DOI: 10.1016/j.msec.2014.12.059

  • Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats. Reviewed International journal

    Ishikawa Kunio, Nguyen Xuan Thanh Tram, Kanji Tsuru, Toita Riki

    J Mater Sci: Mater Med   26 ( 2 )   94 - 101   2015.2

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  • Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells. Reviewed International journal

    Ishikawa Kunio, Nagai H, Fujioka-Kobayashi M, Fujisawa K, Ohe G, Takamaru N, Hara K, Uchida D, Tamatani T, Miyamoto Y

    J Mater Sci: Mater Med   26 ( 2 )   99 - 107   2015.2

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  • Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam. International journal

    Munar GM, MUNAR MELVIN DE LEON, Tsuru Kanji, Ishikawa Kunio

    Bio-Medical Materials and Engineering   24 ( 5 )   1817 - 1825   2014.5

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  • Fabrication of carbonate apatite block from set gypsum based on dissolution-precipitation reaction in phosphate-carbonate mixed solution. Reviewed International journal

    Ishikawa Kunio, Tsuru Kanji, Ichiro Takahashi

    Dental Materials Journal   33 ( (2) )   166 - 172   2014.3

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  • Fabrication of carbonate apatite block from set gypsum based on dissolution-precipitation reaction in phosphate-carbonate mixed solution. Reviewed International journal

    Nomura S, Tsuru Kanji, Matsuya S, Ichiro Takahashi, Ishikawa Kunio

    Dent Mater J, 33(2): 166-172,   33 ( (2): )   166 - 172   2014.3

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  • Mechanical behavior and cell response of PCL coated α-TCP foam for cancellous-type bone replacement. Reviewed International journal

    39 ( (5): )   5631- - 5637   2013.7

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  • Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam. Reviewed International journal

    Munar GM, Munar ML, Tsuru Kanji, Ishikawa Kunio

    Dent Mater J, 32(4):608-614   32 ( (4): )   608- - 614   2013.7

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  • Effects of solution pH on the structure and biocompatibility of Mg-containing TiO2 layer fabricated on titanium by hydrothermal treatment. International journal

    Xingling Shi, Tsuru Kanji, Lingli Xu, Giichiro Kawachi, Ishikawa Kunio

    Applied Surface Science Vols.270   270   445 - 451   2013.4

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  • Changes in the crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate. Reviewed International journal

    Toshiyuki Suge, Kunio Ishikawa, Takashi Matsuo

    American Journal of Dentistry, 25(5): 299-302, 2012.   2012.10

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  • Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor. Reviewed International journal

    Kazuhiro Sunouchi, Kanji Tsuru, Michito Maruta, Giichiro Kawachi, Shigeki Matsuya, Yoshihiro Terada, Kunio Ishikawa

    Dental Materials Journal, 31(4): 549-557, 2012.   2012.7

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  • Fabrication of microporous calcite block from calcium hydroxide compact under carbon dioxide atmosphere at high temperature. Reviewed International journal

    Akihiro Otsu, Kanji Tsuru, Michito Maruta, Melvin L. Munar, Shigeki Matsuya, Kunio Ishikawa:

    Dental Materials Journal, 31(4): 593-600, 2012.   2012.7

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  • Effect of precursor’s solubility on the mechanical property of hydroxyapatite formed by dissolution-precipitation reaction of tricalcium phosphate. Reviewed International journal

    2012.7

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  • Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses. Reviewed International journal

    Shi X, Nakagawa M, Kawachi G, Xu L, Ishikawa K

    J Mater Sci: Mater Med, 23:1281-1290, 2012.   2012.6

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  • Preparation of low-crystalline apatite nanoparticles and their coating onto quartz substrates. Reviewed International journal

    J Mater Sci: Mater Med, 23: 1355-1362, 2012.   2012.6

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  • Preparation of Sr-containing carbonate apatite as a bone substitute and its properties. Reviewed

    Sakai A, Valanezahad A, Ozaki M, Ishikawa K, Matsuya S

    Dent Mater J, 31(2): 197-205, 2012.   2012.4

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  • Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. Reviewed International journal

    Shibata S, Suge T, Kimura T, Ishikawa K, Matsuo T

    Am J Dent, 31(2): 197-205, 2012.   2012.2

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  • A new biocompatible coating layer applied on titanium substrates using a modified zinc phosphatizing method. Reviewed International journal

    Valanezahad A, Tsuru K, Maruta M, Kawachi G, Matsuya S, Ishikawa K

    Surafce & Coating Tech, 206: 2207-2212, 2012.   2012.1

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  • Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor. Reviewed International journal

    Ishikawa Kunio, Kanji Tsuru

    Dental Materials Journal, 31(4): 549-557, 2012.   2012.1

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  • Effect of silicon and heat-treatment temperature on the morphology and mechanical properties of silicon - substituted hydroxyapatite. Reviewed International journal

    Bang LT, Ishikawa K, Othman R

    Ceram Int, 37(8): 3637-3642, 2011.   2011.12

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  • Hydrothermal calcium modification of 316L stainless steel and its apatite forming ability in simulated body fluid. Reviewed

    Valanezahad A, Ishikawa K, Tsuru K, Maruta M, Matsuya S

    2011.10

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  • Comparison of apatite-coated titanium prepared by blast coating and flame spray methods -Evaluation using simulated body fluid and initial histological study Reviewed

    Mano T, Ishikawa K, Harada K, Umeda H, Ueyama Y

    Dent Mater J, 30(4), 431-437, 2011.   2011.7

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  • Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. Reviewed International journal

    Shibata S, Suge T, Ishikawa K, Matsuo T

    Am J Dent, 24: 148-152, 2011.   2011.6

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  • Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam. Reviewed

    Maruta M, Matsuya S, Nakamura S, Ishikawa K

    Dent Mater J, 30(1): 14-20, 2011.   2011.2

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  • Zinc phosphate coating on 316L-type stainless steel using hydrothermal treatment. Reviewed International journal

    Valanezhad A, Tsuru K, Maruta M, Kawachi G, Matsuya S, Ishikawa K

    2010.10

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  • Effect of phosphate solution on setting reaction of α-TCP spheres. Reviewed International journal

    2010.10

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  • Reinforcement of carbonate apatite bone substitutes with carbonate apatite by Ca salt introduction. Reviewed

    Matsumoto K, Tsuru K, Kawachi G, Maruta M, Matsuya S, Takahashi I, Ishikawa K

    J Ceram Soc Jpn, 118(6): 521-524,2010.   2010.6

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  • Fabrication of carbonate apatite block based on internal dissolution-precipitation reaction of dicalcium phosphate and calcium carbonate. Reviewed

    Daitou F, Maruta M, Kawachi G, Tsuru K, Matsuya S, Terada Y, Ishikawa K

    Dent Mater J, 29(3): 303-308, 2010   2010.6

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  • Tissue-response to calcium-bonded titanium surface Reviewed International journal

    Zhang L, Ayukawa Y, LeGeros RZ, Matsuya S, Koyano K, Ishikawa K

    J Biomed Mater Res: Part A, in press   2010.5

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  • Fabrication of low crystalline B-type carbonate apatite block from low crystalline calcite block Reviewed

    J Ceram Soc Jpn, 118(5): 341-344, 2010   2010.5

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  • In vitro osteoconductivity evaluation of alumina treated hydrothermally in CaCl2 solution. Reviewed

    Tarique AAM, Tsuru K, Maruta M, Takeuchi A, Matsuya S, Terada Y, Ishikawa K

    J Ceram Soc Jpn, 118(6): 512-515, 2010   2010.5

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  • Effects of sintering temperature on physical and compositional properties of α-tricalcium phosphate foam Reviewed

    2010.3

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  • Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate Reviewed International journal

    2010.1

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  • Effects of added mannitol on the setting reaction and mechanical strength of apatite cement Reviewed

    Shimogoryo R, Eguro T, Kimura E, Maruta M, Matsuya S, Ishikawa K

    2009.9

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  • Fabrication of freeform bone-filling calcium phosphate ceramics by gypsum 3D printing method Reviewed International journal

    Lowmunkong R, Sohmura T, Suzuki Y, Matsuya S, Ishikawa K

    J Biomed Mater Res B: Appl Biomater, 90(2), 531-539, 2009.   2009.8

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  • Effect of temperature on crystallinity of carbonate apatite foam prepared from α-tricalcium phosphate by hydrothermal treatment Reviewed International journal

    Bio-Med Mater Eng, 19(2-3), 205–211, 2009   2009.7

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  • Fabrication of low-crystallinity hydroxyapatite foam based on the setting reaction of alpha-tricalcium phosphate foam Reviewed International journal

    Karashima S, Takeuchi A, Matsuya S, Udoh K, Koyano K, Ishikawa K

    J Biomed Mater Res A. 88(3):628-633, 2009   2009.3

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  • abrication of B-type carbonate apatite blocks by the phosphorization of free-molding gypsum-calcite composite Reviewed

    Zaman CT, Takeuchi A, Matsuya S, Zaman Q. H. M. S, Ishikawa K

    2008.5

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  • Effect of molding pressure on fabrication of low-crystalline calcite block

    Xin Lin, Shigeki Matsuya, Masaharu Nakagawa, Yoshihiro Terada, Kunio Ishikawa:

    Journal of Materials Science: Materials in Medicine in press   2008.4

  • Fablication of macroporous carbonate apatite foam by hydrothermal conversion of -tricalcium phosphate in carbonate solutions.

    2008.4

  • Effects of thermal treatment on injectability and basic properties of apatite cement containing spherical tetracalcium phosphate made with plasma melting method

    Kunio Ishikawa, Akari Takeuchi, Yumiko Suzuki, Kiyoshi Koyano

    Journal of the Ceramic Society of Japan   2008.4

  • Effects of tricalcium silicate addition on basic properties of α-tricalcium phosphate cement

    2008.4

  • Fabrication of Si-substituted hydroxyapatite foam using calcium silicates

    Q. H. M. Shawket Zaman, Akari Takeuchi, Chowdhury Tanira Zaman, Shigeki Matsuya, Kunio Ishikawa

    Journal of the Ceramic Society of Japan   2008.4

  • Effects of Calcium Phosphate Precipitation Method on Acid Resistance to Apatite Powder and Bovine Tooth

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo, Shigeyuki Ebisu

    Dental Materials Journal   2008.4

  • Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo, Shigeyuki Ebisu

    Dental Materials   2008.4

  • The development of Ti alloys for dental implant with high corrosion resistance and mechanical strength

    Yamazoe J, Nakagawa M, Matono Y, Takeuchi A, Ishikawa K

    Dental Materials Journal   2007.8

  • Development of macropores in calcium carbonate body using novel carbonation method of calcium hydroxide/sodium chloride composite

    Y. Lee, Yeong M. Hahm, Matsuya S, Nakagawa M, Ishikawa K:

    Journal of Materials Science   2007.5

  • The development of Ti alloys for dental implant with high corrosion resistance and mechanical strength.

    Yamazoe J, Nakagawa M, Matono Y, Takeuchi A, Ishikawa K

    Dental Materials Journal,   2007.4

  • Comparison of the effect of added - and -tricalcium phosphate on the basic properties of apatite cement.

    2007.4

  • Comparison of the effect of added α- and β-tricalcium phosphate on the basic properties of apatite cement.

    2007.4

  • The development of Ti alloys for dental implant with high corrosion resistance and mechanical strength.

    Junichi Yamazoe, Masaharu Nakagawa, Yoshinari Matono, Akari Takeuch, Kunio Ishikawa

    Dental Materials Journal   2007.4

  • Histological evaluation of apatite cement containing atelocollagen.

    Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Hideyuki Takano, Shiho Minamiguchi, Masaru Nagayama

    Dental Materials Journal   2007.4

  • Transformation of 3DP gypsum model to HA by treating in ammonium phosphate solution.

    R. Lowmunkong, Sohmura T, Takahashi J, Suzuki Y, Matsuya S, Ishikawa K

    TJournal of Biomedical Materials Research Part B: Applied Biomaterials   2007.4

  • Transformation of 3DP gypsum model to HA by treating in ammonium phosphate solution

    R. Lowmunkong, Sohmura T, Takahashi J, Suzuki Y, Matsuya S, Ishikawa K

    Journal of Biomedical Materials Research Part B   2007.4

  • Fabrication of porous low crystalline calcite block by carbonation of calcium hydroxide compact.

    Shigeki Matsuya, Xin Lin, Koh-ichi Udoh, Masaharu Nakagawa, RyojiShimogoryo, Yoshihiro Terada, Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine,   2007.4

  • Fabrication of porous low crystalline calcite block by carbonation of calcium hydroxide compact.

    Shigeki Matsuya, Xin Lin, Koh-ichi Udoh, Masaharu Nakagawa, RyojiShimogoryo, Yoshihiro Terada, Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine, in press.   2007.4

  • Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion

    T. Suge, A. Kawasaki, K. Ishikawa, T. Matsuo, S. Ebisu

    Dental Materials, in press.   2007.4

  • Effect of molding pressure on fabrication of low-crystalline calcite block.

    Xin Lin, Shigeki Matsuya, Masaharu Nakagawa, Yoshihiro Terada, Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine submitted   2007.4

  • Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions.

    Y. Lee, Y. M. Hahm, Matsuya S, Nakagawa M, Ishikawa K

    Journal of Materials Science   2007.4

  • Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions

    Y. Lee, Y. M. Hahm, Matsuya S, Nakagawa M, Ishikawa K:

    Journal of Materials Science   2007.4

  • Development of macropores in calcium carbonate body using novel carbonation method of calcium hydroxide/sodium chloride composite.

    Y. Lee, Yeong M. Hahm, Matsuya S, Nakagawa M, Ishikawa K

    Journal of Materials Science   2007.4

  • Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration.

    Yoshiya Ueyama, Takahiro Koyama, Kunio Ishikawa, Takamitsu Mano, Yukiko Ogawa, Hitoshi Nagatsuka, Kazuomi Suzuki

    Journal of Materials Science: Materials in Medicine   2006.4

  • Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects.

    Eiichirou Sugimori, Satoru Shintani, Kunio Ishikawa, Hiroyuki Hamanaka

    Dental Materials Journal   2006.4

  • Effects of sintering temperature over 1,300°C on the physical and structural properties of porous hydroxyapatite foam.

    2006.4

  • Fabrication of biporous low-crystalline apatite based on mannitol dissolution from apatite cement.

    Shinya Tajima, Yuji Kishi, Makoto Oda, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa

    Dental Materials Journal   2006.4

  • Effects of plaque control on the patency of dentinal tubules - An in vivo study in beagle dogs.

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo, Shigeki Ebisu

    Journal of Periodontology   2006.4

  • Effect of ammonium hexafluorosilicate on dentinal tubule occlusion for the treatment of dentin hypersensitivity.

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo, Shigeki Ebisu

    Americal Journal of Dentistry   2006.4

  • Corrosion behavior of pure titanium and titanium alloys in various concentration acidulated phosphate fluorides (APF) solutions.

    Yoshinari Matono, Masaharu Nakagawa, Shigeki Matsuya, Kunio Ishikawa, Yoshihiro Terada

    Dental Materials Journal   2006.4

  • Fabrication of hydroxyapatite block from gypsum block based on (NH4)2HPO4 treatment.

    Yumiko Suzuki, Shigeki Matsuya, Koh-ichi Udoh, Masaharu Nakagawa, Yoshihiro Tsukiyama, Kiyoshi Koyano, Kunio Ishikawa

    Dental Materials Journal   24 ( 4 )   515 - 521   2005.1

  • Ammnonium hexafluorosilicate increased acid resistance of bovine enamel and dentine.

    Akiko Kawasaki, Toshiyuki Suge, Kunio Ishikawa, Kazumi Ozaki, Takashi Matsuo, Shigeki Ebisu

    Journal of Materials Science: Materials in Medicine   16 ( 5 )   461 - 466   2005.1

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  • The effect of Pt and Pd alloying additions on the corrosion behavior of titanium in fluoride-containing environments.

    Masaharu Nakagawa, Yoshinari Matono, Shigeki Matsuya, Koh-ichi Udoh, Kunio Ishikawa

    Biomaterials   26 ( 15 )   2239 - 2246   2005.1

  • Effect of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants.

    Masaharu Nakagawa, Zhang Lee, Ko-ichi Udoh, Shigeki Matsuya, Kunio Ishikawa

    Journal of Materials Science: Materials in Medicine   16 ( 11 )   985 - 991   2005.1

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  • Proliferation and differentiation of cultured MC3T3-E1 osteoblasts on surface-layer modified hydroxyapatite ceramics with acid and heat treatments.

    Tetsuya Yuasa, Youji Miyamoto, Masayuki Kon, Kunio Ishikawa, Masaaki Takechi, Yukihiro Momota, Seiko Takehara, Hideyuki Takano, Shiho Mimamiguchi, Masaru Nagayama

    Dental Mateials Jounal   24 ( 2 )   207 - 212   2005.1

  • Effects of pre- or post-application of calcium chloride on occluding ability of potassium oxalate for the treatment of dentin hypersensitivity.

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa Takashi Matsuo, Shigeki Ebisu

    Americal Journal of Dentistry   18 ( 2 )   121 - 125   2005.1

  • Comparison of the occluding ability of dentinal tubules with different morphology between calcium phosphate precipitation method and potassium oxalate treatment.

    Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo, Shigeki Ebisu

    Dental Materials Journal   24 ( 4 )   522 - 529   2005.1

  • Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone.

    Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, S. Tatehata, and Masaru Nagayama

    Journal of Biomedical Materials Research; Applied Biomaterials   69B ( 1 )   99 - 103   2004.1

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  • Basic properties of apatite cement containing spherical tetracalcium phosphate made with plasma melting method. Reviewed

    Kunio Ishikawa, Shigeki Matsuya, Masaharu Nakagawa, Koh-ichi Udoh and Kazuomi Suzuki

    Journal of Materials Science: Materials in Medicine   15 ( 1 )   13 - 17   2004.1

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    DOI: 10.1023/B:JMSM.0000010092.01661.a8

  • Hardening of calcium hydroxide compact by carbonization.

    Kunio Ishikawa, Shigeki Matsuya, Xin Lun, Koh-ichi Udho, Masaharu Nakagawa, Yoshihiko Terada, Hideo Yamada

    Journal of the Ceramic Society of Japan, Suppliment   2004.1

  • Development of self-setting calcium hydroxide preparation using dicalcium phosphate anhydrous and sodium hydrogen posphate aqueous solution.

    Mariko Nakamura, Kunio Ishikawa, Yasuhiro Yoshida, Kazuomi Suzuki, Toshio Yamamoto

    Journal of the Ceramic Society of Japan, Suppliment   112 ( 1308 )   434 - 439   2004.1

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  • Effects of various sterilization methods on the setting and mechanical properties of apatite cement.

    Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama, Kunio Ishikawa

    Journal of Biomedical Materials Research; Applied Biomaterials   69B ( 1 )   58 - 63   2004.1

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  • Hydrolysis of calcite in potassium phosphate solutions.

    Shigeki Matsuya, Koh-ichi Udoh, Masaru Nakagawa, Kunio Ishikawa

    Phosphorous Research Bulletin   2004.1

  • Effects of fluoride on the hydrolysis of calcite in potassium dihydrogen phosphate solution.

    Shigeki Matsuya, Koh-ichi Udoh, Masaru Nakagawa, Kunio Ishikawa

    Phosphorous Research Bulletin   2004.1

  • Effects of added sodium alginate on mechanical strength of apatite cement

    Shinya Tajima, Norihiko Nishimoto, Yuji Kishi, Shigeki Matsuya, Kunio Ishikawa

    Dental Materials Journal   23 ( 3 )   329 - 334   2004.1

  • Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro.

    Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara, Masaru Nagayama

    Biomaterials   25 ( 7-8 )   1159 - 1166   2004.1

  • The Effects of initial hemostatic period on the mechanical strength and transformation of apatite cement.

    Yasuaki Shiga, Ryoji Shimogoryo, Tatsuo Oka, Shigeki Matsuya, Kunio Ishikawa

    Dental Materials Journal   23 ( 3 )   335 - 339   2004.1

  • Biopex® acquires anti-washout properties by adding sodium alginate into its liquid phase. Reviewed

    22 ( 3 )   301 - 312   2003.1

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  • Effects of added bioactive glass on the setting and mechanical properties of resin-modified glass ionomer cement. Reviewed

    Ika Devi Ana, Shigeki Matsuya, Mihio Ohta, Kunio Ishikawa

    Biomaterials   24 ( 18 )   3061 - 3067   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0142-9612(03)00151-0

  • The effects of hardening enviroment on the conversion to apatite and the mechanical strength of apatite cement. Reviewed

    Makoto Oda, Toshio Kaku, Atsushi Ookubo, Shigeki Matsuya, Kunio Ishikawa

    Journal of Japanese Society of Oral Implantology   2003.1

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  • Effect of self-setting primer containing N-acryloyl asparatic acid on enamel adhesion. Reviewed

    Yasuhiro Torii, Kousuke Itou, Yoshihiro Nishitani, Masahiro Yoshiyama, Kunio Ishikawa, Kazuomi Suzuki

    Dental Materials   2003.1

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  • Effects of fluoride release from bis-GMA/TEGDMA resin regulated by γ-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel. Reviewed

    23 ( 16 )   3503 - 3508   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0142-9612(02)00079-0

  • Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells. Reviewed

    Kunio Ishikawa, Youji Miyamoto, Taketomo Toh, Tetsuya Yuasa, Atsuo Ito, Masaru Nagayama, Kazuomi Suzuki

    Biomaterials   2002.1

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  • The in vitro antibiotic release from anti-washout apatite cement using chitosan. Reviewed

    Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seikou Tatehara, Masaru Nagayama, Kunio Ishikawa, Kazuomi Suzuki

    Journal of Materials Science: Materials in Medicine   2002.1

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  • Regulation of NaF release from bis-GMA/TEGDMA resin using γ-methacryloxypropyltrimethoxysilane Reviewed

    2002.1

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  • Regulation of fluoride ion release from Na2SiF6 contained in resin based on hydrophobic siloxane layer coating. Reviewed

    Satoshi Nakabo, Yasuhiro Torii, Toshiyuki Itota, Masahiro Yoshiyama, Kunio Ishikawa, Kazuomi Suzuki

    Journal of Oral Rehabilitation   2002.1

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  • Initial tissue response to a titanium implant coated with apatite at room temperature using a blast coating method Reviewed

    Takamitsu Mano, Yoshiya Ueyama, Kunio Ishikawa, Kazuomi Suzuki, Tomohiro Matsumura

    Biomaterials   2002.1

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  • Calcium phosphate precipitation method for the treatment of dentin hypersensitivity. Reviewed

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Satoru Imazato, Yuichiro Noiri, Kazuomi Suzuki, Takashi Matsuo, Shigeyuki Ebisu

    American Journal of Dentistry   15 ( 4 )   220 - 226   2002.1

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  • Effect of phosphoric acid etching prior to self-etching primer application on adhesion of resin composite to enamel and dentin. Reviewed

    Yasuhiro Torii, Kousuke Itou, Yoshihiro Nishitani, Kunio Ishikawa, Kazuomi Suzuki

    American Journal of Dentistry   2002.1

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  • Usefulness as guided bone regeneration membrane of the alginate membrane. Reviewed

    Yoshiya Ueyama, Kunio Ishikawa, Takamitsu Mano, Takahiro Koyama, Hitoshi Nagatsuka, Kazuomi Suzuki, Kazuo Ryoke

    Biomaterials   2002.1

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  • Evaluation of feasibility of hydroxyapatite putty as a local hemostatic agent for bone. Reviewed

    Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama, Kazuomi Suzuki

    Journal of Biomedical Materials Research: Applied biomaterials   63 ( 5 )   542 - 547   2002.1

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    DOI: 10.1002/jbm.10332

  • Zinc-releasing calcium phosphate for stimulating bone formation. Reviewed

    Atsuo Ito, Haruo Kawamura, Makoto Otsuka, Masako Ikeuchi, Hajime Ohgushi, Kunio Ishikawa, Kazuo Onuma, Nariko Kanzaki, Yu Sogo, Noboru Ichinose

    Materials Science and Engineering C   22 ( 1 )   21 - 25   2002.1

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    DOI: 10.1016/S0928-4931(02)00108-X

  • Effect of added NaHCO3 on the basic properties of apatite cement. Reviewed

    Youji Miyamoto, Taketomo Toh, Kunio Ishikawa, Tetsuya Yuasa, Masaru Nagayama, Kazuomi Suzuki

    Journal of Biomedical Materials Research   2001.1

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  • Effects of plaque control on the occlusion of dentin tubule in situ. Reviewed

    Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Hirotoshi Simizu, Kazuomi Suzuki, Takashi Matsuo, Shigeyuki Ebisu

    Journal of Oral Rehabilitation   2001.1

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  • Effect of priming time on tensile bond strength to bovine tooth and morphological structure of interfaces created by self-etching primers Reviewed

    Kousuke Itou, Yasuhiro Torii, Takehiko Takimura, Kana Chikami, Kunio Ishikawa, Kazuomi Suzuki

    The International Journal of Prosthodontics   2001.1

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  • Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia. Reviewed

    Masaaki Takechi, Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama, Kazuomi Suzuki

    Journal of Materials Science: Materials in Medicine   2001.1

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  • Effects of polysiloxane coating of NaF on the release profile of fluoride ion from bis-GMA/TEGDMA resin containing NaF Reviewed

    Satoshi Nakabo, Yasuhiro Torii, Toshiyuki Itota, Masahiro Yoshiyama, Kunio Ishikawa, Kazuomi Suzuki

    Dental Materilas Journal   2001.1

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  • In vitro resorption of three apatite cements with osteoclasts. Reviewed

    Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masaru Nagayama, Kazuomi Suzuki

    Journal of Biomedical Materials Research   2001.1

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  • Initial tissue response to anti-washout apatite cement in the rat palatal region: Comparison with conventional apatite cement. Reviewed

    Yoshiya Ueyama, Kunio Ishikawa, Takamitsu Mano, Takahiro Koyama, Tomohiro Matsumura, Kazuomi Suzuki

    Journal of Biomedical Materials Research   2001.1

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  • Initial evaluation of a ceramic form as a reconstructive material for bone defect. Reviewed

    Teruo Kasai, Kunio Ishikawa, Kazuomi Suzuki, Hirofumi Yatani

    Dental Materials Journal   2000.1

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  • Pilot study of conditioner/primer effects on resin-dentin bonding after provisional cement contamination using SEM, energy dispersive x-ray spectroscopy, and bond strength evaluation measures. Reviewed

    Elisete Kazumi Watanabe, Hirofumi Yatani, Kunio Ishikawa, Kazuomi Suzuki, Atsushi Yamashita

    The Journal of Prosthetic Dentistry   2000.1

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  • Shear bond strengths of orthodontic plastic brackets. Reviewed

    Guoqiang Guan, Teruko Takano-Yamamoto, Manabu Miyamoto, Tetsuo Hattori, Kunio Ishikawa, Kazuomi Suzuki

    American Journal of Orthodontics and Dentofacial Orthopedics   2000.1

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  • Content and release of bisphenol A from polycarbonate dental products. Reviewed

    Kazuomi Suzuki, Kunio Ishikawa, Katsumi Sugiyama, Hiroaki Furuta, Fumio Nishimura

    Dental Materials Journal   2000.1

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  • Adhesion of restrative resin to teeth: Effects of functional groups of dentin primer to collagen Reviewed

    Kazuomi Suzuki, Kunio Ishikawa, Yoshihiro Nishitani, Kousuke Itou, Yasuhiro Torii, Norihiko Nishiyama, Kimiya Nemoto

    Dentistry in Japan   2000.1

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  • Effect of self-etching primers containing N-acryloyl aspartic acid on dentin adhesion. Reviewed

    Kousuke Itou, Yasuhiro Torii, Yoshihiro Nishitani, Kunio Ishikawa, Kazuomi Suzuki, Kiyoshi Inoue

    Journal of Biomedical Materials Research   2000.1

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  • Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing. Journal of Biomedical Materials Reviewed

    Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama, Kazuomi Suzuki

    Research: Applied Biomaterials   1999.1

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  • Effects of thermocycling on the tensile bond strength between resin cement and dentin surfaces after temporary cement application Reviewed

    Elisete Kazumi Watanabe, Hirofumi Yatani, Atsushi Yamashita, Kunio Ishikawa, Kazuomi Suzuki

    International Journal of Prosthodontics   1999.1

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  • Correlation of dentin bond durability with water absorption of bonding layer Reviewed

    Jiro Tanaka, Kunio Ishikawa, Hirofumi Yatani, Atsushi Yamashita, Kazuomi Suzuki

    Dental Materials Journal   1999.1

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  • Effect of carboxyl group in O-methacryloyl-N-acyl tyrosines on adhesiveness to unetched human dentin Reviewed

    Jiro Tanaka, Kunio Ishikawa, Hirofumi Yatani, Atsushi Yamashita, Kazuomi Suzuki

    Dental Materials Journal   1999.1

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  • Reaction of calcium phosphate cements with different amounts of tetracalcium phosphate and dicalcium phosphate anhydrous. Reviewed

    Kunio Ishikawa, Shozo Takagi, Laurence C Chow, Kazuomi Suzuki

    Journal of Biomedical Materials Research   1999.1

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  • Self-setting barrier membrane for guided tissue regeneration method: Initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions. Reviewed

    Kunio Ishikawa, Yoshiya Ueyama, Takamitsu Mano, Takahiro Koyama, Kazuomi Suzuki, Tomohiro Matsumura

    Journal of Biomedical Materials Research   1999.1

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  • Effects of neutral sodium hydrogen phosphate on setting reaction and mechanical strength of hydroxyapatite putty Reviewed

    Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Yoshiya Ueyama, Kazuomi Suzuki, Masaru Nagayama, Tomohiro Matsumura

    Journal of Biomedical Materials Research   1999.1

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  • Evaluation of post-treatment solutions for clinical use with the calcium phosphate precipitation method. Reviewed

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Kazuomi Suzuki, Takashi Matsuo, Shigeyuki Ebisu

    Journal of Dentistry   1999.1

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  • Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases. Reviewed

    Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama, Kazuomi Suzuki

    Biomaterials   1998.1

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  • Improvement in the tensile bond strength between resin cement and dentin surfaces after temporary cement application. Reviewed

    Elisete Kazumi Watanabe, Atsushi Yamashita, Hirofumi Yatani, Kunio Ishikawa, Kazuomi Suzuki

    The International Journal of Prosthodontics   1998.1

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  • Steric effects of N-acryl group in O-methacryloyl-N-acyl tyrosines on the adhesiveness of unetched human dentin Reviewed

    Jiro Tanaka, Kunio Ishikawa, Hirofumi Yatani, Atsushi Yamashita, Kazuomi Suzuki

    Dental Materials Journal   1998.1

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  • Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation Reviewed

    Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama, Kazuomi Suzuki

    Biomaterials   1998.1

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  • Development of calcium phosphate cement for rapid crystallization to apatite Reviewed

    Masayuki Kon, Youji Miyamoto, Kenzo Asaoka, Kunio Ishikawa, Hae-Hyong Lee

    Dental Materials Journal   1998.1

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  • Formation of hydroxyapatite in new calcium phosphate cements Reviewed

    Shozo Takagi, Laurence C Chow, Kunio Ishikawa

    Biomaterials   1998.1

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  • Tissue response to fast-setting calcium phosphate cement in bone.

    Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Yuki Yoshida, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka

    Journal of Biomedical Materials Research   1997.1

  • Blast coating method: New method of coating titanium surface with hydroxyapatite at room temperature.

    Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama, Kenzo Asaoka

    Journal of Biomedical Materials Research: Applied Biomaterials   1997.1

  • Non-decay type fast-setting calcium phosphate cement: setting behaviour in calf serum and its tissue response.

    Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Miwako Yuasa, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    Biomaterials   1996.1

  • Effects of hexafluorosilicate on the precipitate composition and dentine tubule occlusion by calcium phosphate.

    Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Yoshiyama M, Kenzo Asaoka, Shigeyuki Ebisu

    Journal of Dentistry   1996.1

  • Fluoridation of hydroxyapatite powder by ammonium hexafluorosilicate.

    Hiroko Murata, Kunio Ishikawa, Satoru Tenshin, Shinya Horiuchi, Masaru Nakanishi, Kenzo Asaoka, Terushige Kawata, Teruko Takano-Yamamoto

    Caries Research   1996.1

  • Non-decay type fast-setting calcium phosphate cement using chitosan.

    Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Miwako Yuasa, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka

    Journal of Materials Science: Materials in Medicine   1996.1

  • In vivo setting behaviour of fast-setting calcium phosphate cement.

    Youji Miyamoto, Kunio Ishikawa, Hirokazu Fukao, Masahiro Sawada, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka

    Biomaterials   1995.1

  • Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement.

    Kunio Ishikawa, Kenzo Asaoka

    Journal of Biomedical Materials Research   1995.1

  • Properties and mechanisms of fast-setting calcium phosphate cements.

    Kunio Ishikawa, Shozo Takagi, Laurence C Chow, Yoshiko Ishikawa

    Journal of Materials Science: Materials in Medicine   1995.1

  • Non-decay type fast-setting calcium phosphate cement: composite with sodium alginate.

    Kunio Ishikawa, Youji Miyamoto, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    Biomaterials   1995.1

  • Development of calcium phosphate based functional gradient bioceramics.

    Masayuki Kon, Kunio Ishikawa, Youji Miyamoto, Kenzo Asaoka

    Biomaterials   1995.1

  • Duration of dentinal tubule occlusion formed by calcium phosphate precipitation method: In vitro evaluation using synthetic saliva.

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka, Shigeyuki Ebisu

    Journal of Dental Research   1995.1

  • Effects of fluoride on the calcium phosphate precipitation method for dentinal tubule occlusion.

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka, Shigeyuki Ebisu

    Journal of Dental Research   1995.1

  • Occlusion of dentinal tubules with calcium phosphate using acidic calcium phosphate solution followed by neutralization.

    Kunio Ishikawa, Toshiyuki Suge, Masahiro Yoshiyama, Akiko Kawasaki, Kenzo Asaoka, Shigeyuki Ebisu

    Journal of Dental Research   1994.1

  • Effect of calcium ions on hydroxyapatite formation from the hydrolysis of anhydrous dicalcium phosphate.

    Kunio Ishikawa, Edward David Eanes, Kenzo Asaoka

    Dental Materials Journal   1994.1

  • The effect of supersaturation on apatite crystal formation in aqueous solutions at physiologic pH and temperature.

    Kunio Ishikawa, Edward David Eanes, Ming Sung Tung

    Journal of Dental Research   1994.1

  • Behavior of a calcium phosphate cement in simulated blood plasma in vitro.

    Kunio Ishikawa, Shozo Takagi, Laurence C Chow, Yoshiko Ishikawa, Edward D Eanes, Kenzo Asaoka

    Dental Materials   1994.1

  • Effects of zirconia addition on mechanical strength of hydroxyapatite ceramics.

    Kunio Ishikawa, Yoshiko Ishikawa, Norihiko Kuwayama

    Chemistry Express   1993.1

  • The hydrolysis of anhydrous dicalcium phosphate into hydroxyapatite.

    Kunio Ishikawa, Edward David Eanes

    Journal of Dental Research   1993.1

  • Hydrolysis of octacalcium phosphate to hydroxyapatite in the presence and absence of fluoride, magnesium and hydroxyapatite.

    Kunio Ishikawa, Kenzo Asaoka, Norihiko Kuwayama

    Chemistry Express   1993.1

  • Determination of the Ca/P ratio in calcium-deficient hydroxyapatite using X-ray diffraction analysis.

    Kunio Ishikawa, Paul Ducheyne, Shulamic Radin

    Journal of Materials Science: Materials in Medicine   1993.1

  • Preparation of carbonate-bearing hydroxyapatites and their sintering properties.

    Kunio Ishikawa, Yoshiko Ishikawa, Norihiko Kuwayama

    Chemistry Express   1991.1

  • Effects of zirconia addition on fracture toughness and bending strength of dental porcelains.

    Masayuki Kon, Kunio Ishikawa, Norihiko Kuwayama

    Dental Materials Journal   1990.1

  • Effects of preparation conditions in aqueous solution on properties of hydroxyapatite.

    Kunio Ishikawa, Masayuki Kon, Satoru Tenshin, Norihiko Kuwayama

    Dental Materials Journal   1990.1

  • Preparation of hydroxyapatite with different Ca/P ratio.

    Kunio Ishikawa, Masayuki Kon, Satoru Tenshin, Yoshiko Ishikawa, Norihiko Kuwayama

    Chemistry Express   1990.1

  • Oxygenation and oxidative coupling processes of alkyl ligands of cis-dialkylcobalt(III) complexes with dioxygen, catalyzed by coenzyme analogues in the presence of perchloric acid.

    Kunio Ishikawa, Shunichi Fukuzumi, Tatsuo Goto, Toshio Tanaka

    Journal of American Chemical Society   1990.1

  • Photoinduced radical chain reactions between alkylcobalt(III) complexes and iodine.

    Kunio Ishikawa, Shunichi Fukuzumi, Tatsushi Goto, Toshio Tanaka

    Journal of Chemical Society: Dalton Transaction   1990.1

  • Reductive methylation of NAD+ analogues by a trans-dimethylcobalt (III) complex.

    Shunichi Fukuzumi, Toshiaki Kitano, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1989.1

  • Electron-transfer processes in the electrophilic cleavage of cobalt-carbon bonds of alkylcobalt(III) complexes with iodine.

    Kunio Ishikawa, Shunichi Fukuzumi, Toshio Tanaka

    Inorganic Chemistry   1989.1

  • Reduction of dioxygen by an NADH model compound and 1,1'-dimethylferrocene, catalysed by acids in homogeneous and heterogeneous systems.

    Shunichi Fukuzumi, Makoto Chiba, Masashi Ishikawa, Kunio Ishikawa, Toshio Tanaka

    Journal of Chemical Society: Perkin Transaction II   1989.1

  • Acid-catalysed reduction of flavin analogues by an NADH model compound, 10-methyl-9,10-dihydroacridine and cis-dialkylcobalt(III) complexes.

    Shunichi Fukuzumi, Sadaki Kuroda, Tatsushi Goto, Kunio Ishikawa, Toshio Tanaka

    Journal of Chemical Society: Perkin Transaction II   1989.1

  • Photo-cleavage of cobalt-carbon bonds of alkylcobalt (III) complexes by iodine with large quantum yields.

    Shunichi Fukuzumi, Tatsushi Goto, Kunio Ishikawa, Toshio Tanaka

    Journal of Chemical Society: Chemical Communication   1989.1

  • Coenzyme-catalyzed cleavage of cobalt-carbon bonds in the oxidation of cis-dialkylcobalt(III) complexes by oxygen.

    Shunichi Fukuzumi, Tatsushi Goto, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1988.1

  • Photoredox reactions of cis-dialkylcobalt(III) complexes with benzyl and allyl bromides.

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Organometallics   1987.1

  • Redox reactions of cis-dialkylcobalt(III) complexes with benzyl and allyl bromides, induced by thermal cleavage of the cobalt-carbon bond.

    Kunio Ishikawa, Shunichi Fukuzumi, Toshio Tanaka

    Bulletin of the Chemical Society of Japan   1987.1

  • Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate.

    Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    Journal of Biomedical Materials Research   1987.1

  • Acid catalysis in thermal and photoinduced electron-transfer reactions.

    Shunichi Fukuzumi, Kunio Ishikawa, Katsuhiko Hironaka, Toshio Tanaka

    Journal of Chemical Society: Perkin Transaction II   1987.1

  • Oxidation of cis-dialkylcobalt(III) complexes by oxygen. Activation of oxygen by perchloric acid.

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1986.1

  • Evidence for a single-electron-transfer activation in the cleavage of cobalt-carbon bonds of alkylcobalt(III) complexes with iodine.

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1986.1

  • 有機酸化剤によるcis-ジアルキルコバルト(III)錯体のコバルト-アルキル結合の開裂反応における過塩素酸マグネシウムおよび過塩素酸の触媒作用.

    福住俊一,石川邦夫,田中敏夫

    日本化学会誌   1985.1

  • C-C bond formation by the photoinduced reactions of cis-dialkylcobalt(III) complexes with benzyl and allyl bromides.

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1985.1

  • Electron-transfer reactions from cis-dialkylbis(2,2'-bipyridyl)cobalt(III) complexes to organic oxidants. Journal of Chemical Society

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Dalton Transaction   1985.1

  • Activation of cobalt(III)-alkyl bonds through interaction with organic oxidants and the catalytic effect of Mg2+ ion on alkyl transfer reactions from cis-dialkylcobalt(III) complexes to p-benzoquinone derivatives.

    Shunichi Fukuzumi, Kunio Ishikawa, Toshio Tanaka

    Chemistry Letters   1984.1

  • Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam.

    Ishikawa Kunio, Tsuru Kanji

    Bio-Medical Materials and Engineering, in press.   1900

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  • Effects of humidity on calcite block fabrication using calcium hydroxide compact.

    Ishikawa Kunio, Tsuru Kanji, Ichiro Takahashi

    Ceramics International   1900

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  • Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells.

    Ishikawa Kunio

    Journal of Materials Science: Materials in Medicine   1900

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  • Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats.

    Ishikawa Kunio, Tsuru Kanji, Toita Riki

    Journal of Materials Science: Materials in Medicine   1900

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  • Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats.

    Ishikawa Kunio, Tsuru Kanji, Toita Riki

    Journal of Materials Science: Materials in Medicine   1900

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  • Effect of calcium-ozone treatment on chemical and biological properties of polyethylene terephthalate.

    Ishikawa Kunio

    Journal of Biomedical Materials Research   1900

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▼display all

Presentations

  • Surface functionalization of honeycomb scaffolds consisting of carbonate apatite for bone regeneration and infection prevention

    Masaya SHIMABUKURO, @Koichiro HAYASHI, Taishi YOKOI, Masakazu KAWASHITA, @Kunio ISHIKAWA

    The 2nd international symposium on design & engineering by joint inverse innovation for materials architecture (DEJI2MA 2022)  2022.10 

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    Event date: 2023.6

    Language:English  

    Country:Japan  

  • 炭酸アパタイトハニカム人工骨による長管骨再建

    @石川 邦夫、#柴原 啓吾、@林 幸壱朗、@中島康晴

    日本再生医療学会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:京都国際会議場   Country:Japan  

  • 骨再生・感染予防のための抗菌性炭酸アパタイト骨補填材の開発

    島袋将弥、川下将一、@石川邦夫

    国際・産学連携インヴァースイノベーション材料創出プロジェクト公開討論会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:早大西早稲田キャンパス   Country:Japan  

  • 酸アパタイトハニカム材料の人工造血幹細胞ニッチへの応用

    @林 幸壱朗、@岸田 良、@土谷 享、@石川 邦夫

    日本セラミックス協会2023年年会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:神奈川大学みなとみらいキャンパス   Country:Japan  

  • 骨伝導性と強度を充足する炭酸アパタイトハニカムブロックの開発

    #柴原啓吾、@林幸壱郎、@石川邦夫、@中島康晴

    第41回整形外科バイオマテリアル研究会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:ハピリンホール、福井   Country:Japan  

  • Carbonate apatite honeycomb artificial bone for critical size ulna defect reconstruction International conference

    @Kunio Ishikawa

    Bioceramics 32  2022.9 

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    Event date: 2022.9

    Language:English  

    Country:Italy  

  • 骨再生における炭酸アパタイト骨補填材中のリン酸銀の無毒性量

    @島袋将弥, @塙隆夫, @石川邦夫

    日本金属学会 2022年春期 第170回講演大会  2022.3 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • 進化に学ぶ:炭酸カルシウム前駆体からの炭酸アパタイト人工骨の創製

    @石川 邦夫

    第24回日本歯科医学会学術大会  2021.9 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • 骨組成(炭酸アパタイト)人工骨の機能と展開

    @石川邦夫

    日本骨代謝学会(招待:シンポジウム 硬組織再生を制御する)  2021.10 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • Fabrication of vaterite block and its transformation to carbonate apatite. International conference

    @Kunio Ishikawa, #Keisuke Tanaka, @Akira Tsuchiya

    The 43rd Japanese Society for Biomatrials and 8th Asian BioMaterials Congress  2021.11 

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    Event date: 2022.5

    Language:English  

    Country:Japan  

  • :Carbonate apatite artificial bone fabricated from vaterite replaces to bone quickly. International conference

    @Kunio Ishikawa, #Keisuke Tanaka, @Akira Tsuchiya

    2022 Hawaii-Joint Symposium-SFB+JSB  2022.1 

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    Event date: 2022.5

    Language:English  

    Country:Japan  

  • 炭酸アパタイト人工骨の創製と展開 Invited

    @石川邦夫

    第240回IBBセミナー  2022.1 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • 骨組成(炭酸アパタイト)人工骨の挑戦

    @石川 邦夫

    第9回 日本バイオマテリアル学会 中四国ブロック シンポジウム  2022.2 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • Fabrication and Histological Evaluation of Porous Carbonate Apatite Blocks Using Disodium Hydrogen Phosphate Crystals as Porogen and Phosphatization Accelerator

    2021.12 

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    Event date: 2021.12

    Language:English  

    Country:Japan  

  • Fabrication and Histological Evaluation of Highly Interconnected Porous Carbonate Apatite Blocks Based on The Setting Reaction of Calcium Sulfate Hemihydrate Granules

    2021.12 

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    Event date: 2021.12

    Language:English  

    Country:Japan  

  • 分節型骨欠損におけるハニカム構造を有する炭酸アパタイトの骨伝導性の評価

    #柴原啓吾, @林幸壱朗, @石川邦夫, @中島康晴

    第40回整形外科バイオマテリアル研究会  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Venue:(京都リサーチパーク)   Country:Japan  

  • Effect of carbonate content in carbonate apatite on bone remodeling

    #Kaai Deguchi, @Shunsuke Nomura, @Akira Tsuchiya, @Kunio Ishikawa, @Ichiro Takahashi

    Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium 2021  2021.11 

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    Event date: 2021.11

    Language:English  

    Country:Japan  

  • 炭酸アパタイト中の炭酸基含有量が生体吸収性と骨置換性に及ぼす影響

    #出口佳愛, @野村俊介, @土谷享, @石川邦夫, @高橋一郎

    第80回日本矯正歯科学会学術大会&第5回国際会議  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • Bone reconstruction using three-dimensional interconnected porous CO3Ap block fabricated based on hydrate expansion of CaO granules International conference

    #Keisuke Tanaka, @Akira Tsuchiya, @Yoichiro Ogino, @Yasunori Ayukawa, @Kunio Ishikawa

    The 69th Annual Meeting of Japanese Association for Dental Research  2021.10 

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    Event date: 2021.10

    Language:English  

    Country:Japan  

  • 溶解析出反応の温度が炭酸アパタイトブロックの物理的/化学的性質および骨置換性に与える影響

    #田中啓喬, @土谷享, @鮎川保則, @石川邦夫

    , 第78回日本歯科理工学会学術講演会(web開催)  2021.10 

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    Event date: 2021.10

    Language:Japanese  

    Country:Japan  

  • ハニカムスキャフォールドの微構造が垂直的骨造成に与える影響

    @林 幸壱朗, @石川 邦夫

    日本セラミックス協会第34回秋季シンポジウム  2021.9 

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    Event date: 2021.9

    Language:Japanese  

    Country:Japan  

  • 半水石膏顆粒の硬化反応に基づく炭酸アパタイト3次元多孔体の創製とその生体反応評価

    @岸田良, #Maab Elsheikh, @林幸壱朗, @石川邦夫

    日本セラミックス協会第34回秋季シンポジウム  2021.9 

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    Event date: 2021.9

    Language:Japanese  

    Country:Japan  

  • 人工骨としての炭酸アパタイトの基礎と臨床応用 Invited

    @石川 邦夫

    第94回日本整形外科学会学術総会  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京国際フォーラム&WEB開催   Country:Japan  

  • 炭酸アパタイトハニカムスキャホールドの骨誘導能評価

    @林幸一朗,@石川邦夫

    第75回日本歯科理工学会学術講演会  2021.4 

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    Event date: 2021.4

    Language:Japanese  

    Country:Japan  

  • 我が国発、世界初の骨組成(炭酸アパタイト)骨補填材の創製

    @石川 邦夫

    日本歯科医学会連合第4回大型医療研究推進フォーラム  2021.2 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:WEB開催   Country:Japan  

  • 炭酸アパタイト人工骨による骨再生治療 Invited

    @石川 邦夫

    第62回歯科基礎医学会学術大会  2020.9 

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    Event date: 2020.9 - 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:WEB開催   Country:Japan  

  • 炭酸アパタイトハニカムによるIn situ組織再生法へのアプローチ

    @石川 邦夫

    第129回日本歯科補綴学会学術大会  2020.6 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:WEB開催   Country:Japan  

  • Interconnected Porous Carbonate Apatite. International conference

    @Kunio Ishikawa, @Koichiro Hayashi, @Akira Tsuchiya, @Ryo Kishida

    The 19th Asian Bioceramics Symposium (ABC 2019)  2019.12 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Fabrication of carbonate apatite honeycomb and its histological evaluation for vertical bone augmentation at cranium. International conference

    @Kunio Ishikawa, @Koichiro Hayashi, @Akira Tsuchiya, @Ryo Kishida

    31th Annual meeting of the International Society for Ceramics in Medicine(Bioceramics 31)  2019.11 

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Porous Carbonate Apatite Bone Substitute. International conference

    @Kunio Ishikawa, @Koichiro Hayashi, @Akira Tsuchiya, @Ryo Kishida

    The 13th Pacific Rim Conference of Ceramic Societies (PACRIM13)  2019.10 

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    Event date: 2019.10 - 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Fabrication of Carbonate Apatite Honeycomb and its Tissue Response. International conference

    @Kunio Ishikawa, Naoyuki Fukuda, Kanji Tsuru, @Yoshihide Mori

    30th Annual Congress of the European Society for Biomaterials (ESB2019)  2019.9 

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    Event date: 2019.9

    Language:English  

    Country:Germany  

  • Usefulness of Carbonate Apatite Honeycomb for Vertical Bone Augmentation. International conference

    @Kunio Ishikawa, @Koichiro Hayashi, @Akira Tsuchiya, @Ryo Kishida

    97th General Session & Exhibition of the International Association for Dental Research  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • Carbonate apatite -Next generation artificial bone replacement- Invited International conference

    @Kunio Ishikawa

    Oral and Biomedical Materials Symposiium between Taiwan and Japan  2019.5 

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Vertical Bone Augmentation Using Carbonate Apatite Bone Substitute. International conference

    @Kunio Ishikawa, @Koichiro Hayashi, @Akira Tsuchiya, @Ryo Kishida

    Society for Biomaterials 2019 Annual Meeting & Exposition  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 炭酸アパタイトハニカム構造体の作製と骨および骨髄再生

    @林 幸壱朗, @石川 邦夫

    日本セラミックス協会2019年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:工学院大学   Country:Japan  

  • 炭酸アパタイト骨補填材の創成

    @石川邦夫

    日本セラミックス協会2019年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:工学院大学   Country:Japan  

  • 炭酸アパタイトハニカム骨補填材による垂直骨造成

    @石川邦夫

    第18回日本再生医療学会総会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場   Country:Japan  

  • 炭酸アパタイト被覆カルサイトの調製とin vivo評価

    @都留寛治,@小林真左子,@石川邦夫,@宮本洋二

    第24回日本アパタイト研究会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄県   Country:Japan  

  • α型リン酸三カルシウム球の硬化による低結晶性ハイドロキアパタト多孔体作製

    @岸田 良, @Tya Indah Arifta, @石川邦夫

    第40回日本バイオマテリアル学会大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:兵庫県神戸市   Country:Japan  

  • マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の作製およびその骨再建への応用

    @秋田和也,@福田直志,@大江剛,@真野隆充,@都留寛治,@石川邦夫,@宮本洋二

    日本バイオマテリアル学会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:兵庫県神戸市   Country:Japan  

  • 気孔径が炭酸アパタイトハニカムの骨伝導性に及ぼす影響

    @石川邦夫, @林幸壱朗, @土谷 享, @都留寛治, @杉浦悠紀

    第40回日本バイオマテリアル学会大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:兵庫県神戸市   Country:Japan  

  • アパタイト被覆による石膏系骨補填材の溶解制御おび伝導性評価

    @土谷 享, #佐藤まりの, @石川邦夫

    第40回日本バイオマテリアル学会大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:兵庫県神戸市   Country:Japan  

  • マイクロファバーを用いた多孔質炭酸アパタト顆粒の作製およびそ骨再建へ応用

    @秋田和也, @福田直志, @大江 剛, @真野隆充, @都留寛治, @石川邦夫, @宮本洋二

    第40回日本バイオマテリアル学会大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:兵庫県神戸市   Country:Japan  

  • Fabrication of Porous β-TCP Block by Heating β-TCP Granules Bridged with DCPD. International conference

    2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Nagoya   Country:Japan  

  • Carbonate apatite: Innovation for Future Bone Regenerative Therapy. International conference

    @Kunio Ishikawa

    18th Asian BioCeramics  2018.9 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発と骨再建への応用

    @秋田和也,@福田直志,@鎌田久美子, @大江剛,@眞野隆充,@都留寛治,@石川邦夫,@宮本 洋二

    第48回日本口腔インプラント学会学術大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪府大阪市   Country:Japan  

  • Fabrication of carbonate apatite honeycomb and its tissue response. International conference

    @Kunio Ishikawa, @Melvin Munar, @Koichiro Hayashi

    29th Annual Congress of the European Society for Biomaterials  2018.9 

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    Event date: 2018.9

    Language:English  

    Country:Netherlands  

  • 骨に学ぶ:炭酸アパタイト骨補填材の開発と臨床応用

    @都留寛治,@石川邦夫

    第60回歯科基礎医学会学術大会,アップデートシンポジウム7「インプラント臨床を発展させる日本のバイオマテリアル」  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡県福岡市   Country:Japan  

  • Carbonate apatite -Next generation artificial bone augmentation material-. Invited International conference

    @Kunio Ishikawa

    3rd Indonesian Materials Research Society  2018.8 

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    Event date: 2018.7 - 2018.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Indonesia  

  • Fabrication of carbonate apatite honeycomb granules. International conference

    @K.Ishikawa, @M. Mumur, @K.Hayashi

    96th General Session & Exhibition of the International Association for Dental Research  2018.7 

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    Event date: 2018.7

    Language:English  

    Country:United Kingdom  

  • Fabrication and evaluation of β-tricalcium phosphate granules cement. International conference

    2018.6 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Perugia   Country:Italy  

  • Physical and Histological Comparison of HAp, CO3Ap, and beta-TCP Artificial Bone Substitutes. Invited International conference

    @K Ishikawa, @A Tsuchiya, @K Hayashi, @Y Miyamoto, @K Tsuru

    Society for biomaterials 2018 annual meeting & exposition  2018.4 

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    Event date: 2018.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 多孔体形成セメントの創製

    石川邦夫, 福田直志、都留寛治

    第17回日本再生医療学会総会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川県横浜市   Country:Japan  

  • Fabrication of calcium sulfate hemihydrate coated β-tricalcium phosphate through dissolution-precipitation reaction. International conference

    2018.3 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Berlin   Country:Germany  

  • Carbonate apatite: Next generation artificial bone replacement International conference

    Ishikawa Kunio

    3rd Annual Conference and Expo on Biomaterials  2018.3 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  • Fabrication and Evaluation of Carbonate Apatite-coated Calcium Carbonate Bone Substitutes. International conference

    Masako Fujioka-Kobayashi, Kanji Tsuru, Kunio Ishikawa, Youji Miyamoto

    The 4th National Osteology Symposium in Switzerland  2018.1 

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    Event date: 2018.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Switzerland  

  • ウサギ大腿骨へ埋埴した炭酸アパタイト顆粒における骨置換率の評価

    林幸壱朗,土谷 享,杉浦悠紀,石川邦夫

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • ウサギ大腿骨へ埋埴した炭酸アパタイト顆粒における骨置換率の評価

    石川邦夫、林幸壱朗、土谷享、杉浦悠紀

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都   Country:Japan  

  • ウサギ大腿骨へ埋埴した炭酸アパタイト顆粒の吸収性に関する評価

    土谷 享,林幸壱朗,杉浦悠紀,石川邦夫

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 炭酸アパタイト顆粒のin vitro における溶解性試験

    林幸壱朗,土谷享,杉浦悠紀,石川邦夫

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 炭酸アパタイト顆粒のイヌ抜歯窩における吸収性評価

    杉浦悠紀,林幸壱朗,土谷享,石川邦夫

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 炭酸アパタイトとコラーゲン複合化による柔軟性のある骨再建用バイオマテリアルの開発

    秋田和也,福田直志,藤澤健司,宮本洋二,都留寛治、石川邦夫

    第39回日本バイオマテリアル学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • Improved osteoconductivity of β-TCP granules by DCPD coating technique. International conference

    2017.10 

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    Event date: 2017.10

    Language:English  

    Venue:Toulouse   Country:France  

  • Calcium phosphate granules cement for bone defect reconstruction International conference

    Ishikawa Kunio

    29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 29)  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  • Carbonate apatite coating on PLGA/CO3Ap foam by compositional transformation through dissolution precipitation reaction International conference

    Melvin de Leon Munar, Girlie Micu Munar, Kanji Tsuru, Kunio Ishikawa

    29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 29)  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  • Fabrication of self-setting beta tricalcium phosphate granular cement through dissolution precipitation reaction. International conference

    Eddy, Akira Tsuchiya, Kanji Tsuru; Kunio Ishikawa

    29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 29)  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  • Nerve regeneration potential of carbonated apatite-gelatin membrane: a study on PC12 cells. International conference

    Retno Ardhani,, Ika Dewi Ana, Kunio Ishikawa, Yasuhiko Tabata

    29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 29)  2017.10 

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    Event date: 2017.10

    Language:English  

    Country:France  

  • Fabrication of porous βTCP block by heating βTCP granules bridged with DCPD. International conference

    2017.10 

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    Event date: 2017.10

    Language:English  

    Venue:Toulouse   Country:France  

  • ウサギ大腿骨へ埋埴した炭酸アパタイト顆粒における新生骨強度の変化

    土谷 享,都留寛治,杉浦悠紀,石川邦夫

    第70 回日本歯科理工学会学術講演  2017.10 

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    Event date: 2017.10

    Language:Japanese  

    Venue:新潟県新潟市   Country:Japan  

  • イヌ下顎骨欠損モデルを用いた炭酸アパタイト顆粒の骨形成能比較評価

    第70回日本歯科理工学会学術講演会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟県新潟市   Country:Japan  

  • インプラント抜歯即時埋入モデルを用いた炭酸アパタイト顆粒の評価

    杉浦悠紀,都留寛治,土谷 享,石川邦夫

    第70 回日本歯科理工学会学術講演  2017.10 

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    Event date: 2017.10

    Language:Japanese  

    Venue:新潟県新潟市   Country:Japan  

  • 炭酸アパタイト顆粒のイヌインプラント周囲におけるin vivo 評価

    都留寛治,土谷 享,杉浦悠紀,石川邦夫

    第70 回日本歯科理工学会学術講演  2017.10 

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    Event date: 2017.10

    Language:Japanese  

    Venue:新潟県新潟市   Country:Japan  

  • Fabrication and tissue response to self-setting β-tricalcium phophate cement International conference

    2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Timisoara   Country:Romania  

  • Calcium Phosphate Granules Cement for Bone Defect Reconstruction International conference

    Ishikawa Kunio

    28th Annual Conference of the European Society for Biomaterials (ESB2017)  2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Greece  

  • Carbonate apatite bone replacement Invited International conference

    Ishikawa Kunio

    2017 International Symposium of Biotechnology on Biomaterials, Stem cells and Tissue Engineering (ISBBST 2017)  2017.8 

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Fabrication and tissue response to self-setting β-tricalcium phosphate granules cement International conference

    2017.8 

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:New Taipei City   Country:Taiwan, Province of China  

  • Fabrication of porous carbonate apatite bone replacement using calcium sulfate granules as precursor International conference

    Ishikawa Kunio

    The 12th Pacific Rim Conference on Ceramic and Glass Technology  2017.5 

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    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Fabrication of carbonate apatite honeycomb and its in vivo evaluation International conference

    Ishikawa Kunio

    Society for Biomaterials (2017 Annual Meeting & Exposition)  2017.4 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 炭酸アパタイトハニカム人工骨置換材の調製

    石川 邦夫, 都留 寛治, MUNAR MELVIN DE LEON

    第16回日本再生医療学会総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台国際センター   Country:Japan  

  • Surface modification of titanium for improved osteoconductivity. International conference

    Ishikawa Kunio

    16th Australasian BioCeramic Symposium  2016.12 

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  • 炭酸アパタイトハニカム

    石川 邦夫, MUNAR MELVIN DE LEON, 都留 寛治

    第52回九大生体材料・力学研究会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Co-immobilization of calcium and phosphate ion to titanium and its bioactivity.

    Sunarso, Riki Toita, Kanji Tsuru, Ishikawa Kunio

    2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 新しい骨補填材の開発:アカデミアの立場から

    石川 邦夫

    日本バイオマテリアル学会シンポジウム2016  2016.11 

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    Event date: 2016.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 低結晶性炭酸アパタイトの骨再建への応用―各種骨補填材との比較―

    藤澤 健司, 永井 宏和, 大江 剛, 都留 寛治, 石川 邦夫, 宮本 洋二

    日本バイオマテリアル学会シンポジウム2016  2016.11 

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    Event date: 2016.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 炭酸アパタイトのウサギ大腿骨への埋植による新生骨強度の評価

    重光 勇介, 山本 克史, 石原 容子, 山中 克之, 増田 聖, 都留 寛治, 石川 邦夫, 熊谷 知弘

    日本バイオマテリアル学会シンポジウム2016  2016.11 

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    Event date: 2016.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • β-TCP顆粒セメントの作製とその組織学的評価

    福田 直志, 都留 寛治, 森 悦秀, 石川 邦夫

    日本バイオマテリアル学会シンポジウム2016  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Carbonate apatite ceramics derived from avian bone by hydrothermal treatment.

    MUNAR MELVIN DE LEON, Kanji Tsuru, Ishikawa Kunio

    2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Fabrication of biphasic bone substitute consisting of calcite and carbonate apatite. International conference

    Kanji Tsuru, MUNAR MELVIN DE LEON, Ishikawa Kunio

    International Dental Materials Congress 2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • Carbonate apatite bone replacement. Invited International conference

    Ishikawa Kunio

    International Dental Materials Congress 2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • Fabrication of carbonate apatite foam from the set calcium sulfate hemihydrate foam via solution mediated phase conversion. International conference

    Yuki Sugiura, Kanji Tsuru, Ishikawa Kunio

    International Dental Materials Congress 2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • Fabrication of porous carbonate apatite for bone repair. International conference

    Nguyen Xuan Thanh Tram, Huynh Tuan Thanh, Ishikawa Kunio

    AUN/SEED-Net Regional Conference 2016 on Materials Engineering (RCME2016)  2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Myanmar  

  • Carbonate apatite -Next generation artificial bone replacement- Invited International conference

    Ishikawa Kunio

    AUN/SEED-Net Regional Conference 2016 on Materials Engineering (RCME2016)  2016.10 

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    Event date: 2016.10

    Language:English  

    Country:Myanmar  

  • Mechanical strength improvement of apatite cement using hydroxyapatite/collagen nanocomposite

    Arief Cahyanto, Kanji Tsuru, Kunio Ishikawa, Masanori Kikuchi

    28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016  2017 

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    Event date: 2016.10

    Language:English  

    Country:United States  

  • Fabrication of carbonate apatite based on dissolution-precipitation reaction using precursors. International conference

    Ishikawa Kunio

    The 28th Symposium & Annual Meeting of the International Society for Ceramics in Medicine  2016.10 

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    Event date: 2016.10

    Language:English  

    Country:United States  

  • 低結晶性炭酸アパタイトのインプラント領域への応用-犬顎骨へのインプラント体との同時埋植-

    藤澤 健司, 永井 宏和, 大江 剛, 高丸 菜都美, 都留 寛治, 石川 邦夫

    口腔インプラント学会総会  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 整形外科・歯科領域コンビネーション製品評価指標素案の政策-革新的医薬品・医療機器・再生医療製品実用化促進事業による取組

    柳 健一, 伊藤 敦夫, 野口 裕史, 橋本 幸一, 山崎 正志, 石川 邦夫, 松川 昭博, 荒川 義弘

    レギュラトリーサイエンス学会  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:京都   Country:Japan  

  • DCPD被膜βTCP顆粒骨補填材の創性

    石川 邦夫, 都留 寛治, Khairul Anuar Shariff

    日本セラミックス協会第29回秋季シンポジウム  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:広島大学   Country:Japan  

  • リン酸カルシウムセメントの歴史

    石川 邦夫

    日本セラミックス協会第29回秋季シンポジウム  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:広島大学   Country:Japan  

  • Carbonate apatite-next generation bone replacement. Invited International conference

    Ishikawa Kunio

    18th International School-Conference "Advanced Materials and Technologies"  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Other  

  • Artificial bone substitute made by dissolution-precipitation method. International conference

    Ishikawa Kunio

    2nd Bone and Biomaterials workshop  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Finland  

  • Calcium Phosphate Cement Development and Its Future. Invited International conference

    Ishikawa Kunio

    ASEAN+3 Course on Bioceramics and Tissue Engineering  2016.7 

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    Event date: 2016.7 - 2016.8

    Language:English  

    Country:Indonesia  

  • Types of Bioceramics: Its Development to Application Invited International conference

    Ishikawa Kunio

    ASEAN+3 Course on Bioceramics and Tissue Engineering  2016.7 

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    Event date: 2016.7 - 2016.8

    Language:English  

    Country:Indonesia  

  • Fabrication of calcite block with interconnecting porous structure for bone substitutes

    Nguyen Xuan Thanh Tram, Kunio Ishikawa

    6th International Conference on the Development of Biomedical Engineering in Vietnam, BME 2016  2018.1 

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    Event date: 2016.6

    Language:English  

    Country:Viet Nam  

  • Effects of the pore size on mechanical property and tissues response to porous carbonate apatite made by the setting reaction of carbonate apatite granules. Invited International conference

    Ishikawa Kunio, Kanji Tsuru, Song Chen

    International Conference on Processing & Manufacturing of advanced materials (Thermec 2016)  2016.6 

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    Event date: 2016.5 - 2016.6

    Language:English  

    Country:Austria  

  • Fabrication of porous carbonate apatite based on setting reaction of carbonate apatite granules. International conference

    Ishikawa Kunio, Kanji Tsuru, Song Chen

    10th World Biomaterials Congress  2016.5 

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    Event date: 2016.5

    Language:English  

    Country:Canada  

  • Fabrication of interconnected porous carbonate apatite and its tissue response.

    Ishikawa Kunio, Kanji Tsuru

    45th Annual Meeting and Exhibition of the American Association for Dental Research  2016.3 

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    Event date: 2016.3

    Language:English  

    Country:United States  

  • 含リン酸半水石膏軟化体からの高強度炭酸アパタイトフォームの創製

    石川 邦夫, 杉浦 悠紀, 都留 寛治

    日本セラミックス協会2016年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:早稲田大学   Country:Japan  

  • ヒトデ由来炭酸カルシウムを前駆体としたリン酸カルシウム多孔体の調整

    柘殖 智仁, 竹内 あかり, 石川 邦夫, 菊池 正紀

    日本セラミックス協会2016年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:早稲田大学   Country:Japan  

  • 炭酸アパタイト顆粒の結合による炭酸アパタイト連通多気孔調整

    石川 邦夫, 吉本 彰夫

    インプラント学会第35回関東・甲信越支部学術大会  2016.2 

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    Event date: 2016.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 顆粒連結法による連通気孔型骨補填材の創製

    石川 邦夫, 都留 寛治

    日本機械学会 第28回バイオエンジニアリング講演会  2016.1 

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    Event date: 2016.1

    Language:Japanese  

    Venue:東京工業大学 大岡山キャンパス   Country:Japan  

  • α型リン酸三カルシウムフォーム顆粒の硬化反応による炭酸アパタイトフォームの調整

    石川 邦夫, 杉浦 悠紀, 都留 寛治

    第37回日本バイオマテリアル学会  2015.11 

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    Event date: 2015.11

    Language:Japanese  

    Venue:京都テルサ   Country:Japan  

  • セラミックス系バイオマテリアルの基礎

    石川 邦夫

    第37回日本バイオマテリアル学会  2015.11 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京都テルサ   Country:Japan  

  • Isolation of carbonate apatite from chicken bone International conference

    Ishikawa Kunio, Nguyen Xuan Thanh Tram, Nguyen Thi Thanh Ueyn, Huynh Tuan Thanh, Huynh Bao Xuyen, Tran Thi Thu Trang, Cao Xuan Viet

    Regional Conference 2015 on Materials Engineering  2015.10 

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    Event date: 2015.10

    Language:English  

    Country:Thailand  

  • Interconnected porous carbonate apatite for bone replacement Invited International conference

    Ishikawa Kunio

    Regional Conference 2015 on Materials Engineering  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • Increased pre-osteoblast bioactivity on ca-modified titanium

    C. Sunarso, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015  2016 

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    Event date: 2015.10

    Language:English  

    Country:Indonesia  

  • Carbonate apatite for bone regeneration: An insight to the future development International conference

    Ishikawa Kunio

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Indonesia  

  • Transformation of apatite cement to B-type carbonate apatite using different atomosphere International conference

    Ishikawa Kunio, Arief Cahyanto, Kanji Tsuru

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Indonesia  

  • Carbonate apatite foam fabricated from α-TCP foam granuels through hydrotheremal treatment with various amount of NaHCO3 International conference

    2015.10 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

  • Osteocnduvitiy and bioresorption of an interconnecting porous carbonate apatite with enhanced mechanical strength International conference

    Ishikawa Kunio, Nguyen Xuan Thanh Tram, Michio Murata, Kanji Tsuru, Shigeki Matsuya

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine  2015.10 

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    Event date: 2015.10

    Language:English  

    Country:Indonesia  

  • Increased pre-osteoblast resorptions to CaCl2 treated titanium at 80℃ International conference

    2015.10 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

  • Preparation of porous αTCP block by fusion of DCPD coated αTCP spheres International conference

    2015.10 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

  • Fabrication of interconnected porous carbonate apatite using calcite granules as a precursor International conference

    Ishikawa Kunio, Noriko Koga, Kanji Tsuru, Ichiro Takahashi

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine  2015.10 

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    Event date: 2015.10

    Language:English  

    Country:Indonesia  

  • Transformation of apatite cement to B-Type carbonate apatite using different atmosphere

    Arief Cahyanto, Kanji Tsuru, Kunio Ishikawa

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015  2016 

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    Event date: 2015.10

    Language:English  

    Country:Indonesia  

  • Regulation of DCPD formation on β-TCP granular surface by exposing different concentration of acidic calcium phosphate solution

    2016 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

    Regulation of DCPD formation on β-TCP granules was achieved by exposing β-TCP granular with different concentration of acidic calcium phosphate solution. It was found that a higher amount of DCPD was formed when exposed β-TCP granular with the higher concentration of acidic calcium phosphate solution. Morphological observation shows that the surface of β-TCP granular was fully coated with DCPD crystals after exposed to the higher concentration of acidic calcium phosphate solution. These results demonstrated that the DCPD formation on the β-TCP granular surface could be regulated by varying the concentration of acidic calcium phosphate solution.

  • Preparation of Porous α-TCP by Fusion of DCPD Coated α-TCP Spheres

    2016 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

    The aim of present study was to fabricate porous α-Tricalcium phosphate (α-TCP) with adequate mechanical strength and pore interconnectivity. First step, α-TCP spheres were exposed to acidic calcium phosphate solution to allow growth and interlocking of dicalcium phosphate dihydrate (DCPD) crystals precipitated on the surface of the α-TCP spheres. Then, the DCPDcoated α-TCP spheres were sintered at 1,500°C for 6h, which resulted in the fusion of spheres to form the interconnected porous block. XRD analysis showed single phase α-TCP was obtained. Mechanical strength of porous α-TCP was 6.9 ± 1.6 MPa and porosity was 53 ± 5%. The obtained porous α-TCP could be employed as potential bone substitute or precursor for other bioceramics like carbonate apatite and hydroxyapatite.

  • Osteoconductivity and bioresorption of an interconnecting porous carbonate apatite with enhanced mechanical strength

    Nguyen Xuan Thanh Tram, Michito Maruta, Kanji Tusru, Shigeki Matsuya, Kunio Ishikawa

    27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015  2016 

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    Event date: 2015.10

    Language:English  

    Country:Indonesia  

  • 炭酸カルシム連通多孔体の作製とその病理組織学的検索

    石川 邦夫, 都留 寛治, 古賀 のりこ, 高橋 一郎

    第66回日本歯科理工学会学術講演会  2015.10 

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    Event date: 2015.10

    Language:Japanese  

    Venue:東京   Country:Japan  

  • α-TCP-DCPD 硬化反応を応用した高炭酸含有アパタイトフォーム創製

    石川 邦夫, 都留 寛治, 杉浦 悠紀

    第66回日本歯科理工学会学術講演会  2015.10 

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    Event date: 2015.10

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Regulation of DCPD formation on β-TCP granular surface by exposing different concentration of acidic calcium phosphate solution International conference

    2015.10 

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    Event date: 2015.10

    Language:English  

    Venue:Bali   Country:Indonesia  

  • 低結晶性炭酸アパタイトの骨再建への応用-イヌ顎骨に作成した骨欠損部への移植

    石川 邦夫, 永井 宏和, 藤澤 健司, 都留 寛治, 宮本 洋二

    日本口腔インプラント学会  2015.9 

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    Event date: 2015.9

    Language:Japanese  

    Venue:岡山   Country:Japan  

  • Comparison of hydroxyapatite and carbonate apatite as bone substitutes International conference

    Ishikawa Kunio

    International Seminar on Biomaterials & Regenerative Medicine (BioRemed 2015)  2015.9 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Romania  

  • Flowability and mechanical property improvement of apatite cement International conference

    Ishikawa Kunio, Ira Artilia

    Dies Forum 2015  2015.9 

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    Event date: 2015.9

    Language:English  

    Country:Indonesia  

  • Fabrication and Histological Evaluation of Carbonate Apatite Coated Calcite International conference

    Ishikawa Kunio, Kanji Tsuru, Masako Kobayashi, Youji Miyamoto

    ESB2015  2015.9 

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    Event date: 2015.8 - 2015.9

    Language:English  

    Country:Poland  

  • オゾン-カルシウム処理による生体親和性PETの創製

    石川 邦夫, 都留 寛治, Ahmed Nafis Rashid

    日本組織培養学会第88回大会  2015.5 

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    Event date: 2015.5

    Language:Japanese  

    Venue:広島大学   Country:Japan  

  • Carbonate Apatite Bone Replacement International conference

    Ishikawa Kunio, Kanji Tsuru, Youji Miyamoto

    The 5th Asian Biomaterials Congress  2015.5 

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    Event date: 2015.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Fabrication of porous carbonate apatite and its in vivo evaluation International conference

    Ishikawa Kunio, Kanji Tsuru, Nguyen Xuan Thanh Tram

    2015 Annual Meeting & Exposition Society for Biomaterials  2015.4 

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    Event date: 2015.4

    Language:English  

    Country:United States  

  • 蟻の巣型炭酸アパタイト多孔体の調整とその組織反応

    石川 邦夫, 都留 寛治, Nguyen Xuan Thanh Tram

    日本再生医療学会  2015.3 

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    Event date: 2015.3

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • PLGA 階層化炭酸アパタイトフォームの界面制御

    石川 邦夫

    融合マテリアル  2015.1 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:北九州国際会議場   Country:Japan  

  • 炭酸アパタイト多孔体の調製と組織反応.

    石川 邦夫, Tram Xuan Thanh Nguyen, 都留 寛治

    第34回整形外科バイオマテリアル研究会  2014.12 

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    Event date: 2014.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • αリン酸型三カルシウム前駆体を用いた炭酸アパタイト調整におけるpHの影響

    石川 邦夫, 都留 寛治, 石川 真帆

    生体関連セラミックス討論会  2014.12 

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    Event date: 2014.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • α型リン酸三カルシウム前駆体を用いた炭酸アパタイト調製におけるpHの影響.

    石川真帆, 都留 寛治, 石川 邦夫

    生体関連セラミックス討論会  2014.12 

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    Event date: 2014.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 連通気孔型炭酸アパタイトの力学的強さ改善

    都留 寛治, Tram Xuan Thanh Nguyen, 丸田道人, 松家茂樹, 石川 邦夫

    生体関連セラミックス討論会  2014.12 

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    Event date: 2014.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • Pre-osteoblast cell responses on phosphate and calcium co-immobilized titanium. International conference

    Sunarso, Toita Riki, Tsuru Kanji, Ishikawa Kunio

    ESB  2014.12 

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    Event date: 2014.12

    Language:English  

    Country:Japan  

  • 抗菌薬含有α-TCP/AC硬化体の顎骨骨髄炎への応用に関する基礎的研究

    石川 邦夫, 都留 寛治, 佐々木 和起, 武知 正晃, 二宮 嘉昭, 太田 耕司, Mohammad Zeshaan Rahman

    第36回日本バイオマテリアル学会大会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 炭酸アパタイト被覆炭酸カルシウムを用いたハイブリッド型骨補填材料による骨再生の試み

    石川 邦夫, 都留 寛治, 小林 真左子, 藤澤 健司, 山中 克之, 熊谷 知弘, 宮本 洋二

    第36回日本バイオマテリアル学会大会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Carbonate apatite bone replacement -Porous carbonate apatite-. Invited International conference

    Ishikawa Kunio

    AUN/SEED-NET regional conference on materials engineering 2014  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Malaysia  

  • Effect of particle size on carbonate apatite cement properties consisting of calcite (Or vaterite) and dicalcium phosphate anhydrous

    Arief Cahyanto, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014  2015 

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    Event date: 2014.11

    Language:English  

    Country:Spain  

  • Basic properties of FGF-2 adsorbed carbonate apatite granular. International conference

    Ishikawa Kunio, Takako Yoshida, Toita Riki, Tsuru Kanji

    Bioceramics 2014  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Spain  

  • Effect of particle size on carbonate apatite cement properties consisting of calcite or vaterite and dicalcium phosphate anhydrous. International conference

    Arif Cahyano, Tsuru Kanji, Ishikawa Kunio

    Bioceramics 2014  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Spain  

  • Comparison of Cells and Tissue Response to Carbonate Apatite and Hydroxyapatite. International conference

    Ishikawa Kunio

    ABC2014  2014.10 

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    Event date: 2014.10

    Language:English  

    Country:China  

  • Traditional bioceramics for future. Invited International conference

    Ishikawa Kunio

    ABC2014  2014.10 

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    Event date: 2014.10

    Language:English  

    Country:China  

  • Fabrication and Evaluation of Porous Carbonate Apatite. International conference

    Ishikawa Kunio

    Biommedd  2014.9 

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    Event date: 2014.9

    Language:English  

    Country:Romania  

  • α-TCPフォーム顆粒を用いた連通気孔型骨セメントの創製

    都留 寛治, Khairul Anuar Shariff, 戸井田 力, 石川 邦夫

    日本セラミックス協会  2014.9 

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    Event date: 2014.9

    Language:Japanese  

    Venue:鹿児島大学   Country:Japan  

  • α-TCPフォーム顆粒を用いた連通気孔型骨セメントの創製

    都留 寛治, 石川 邦夫

    日本セラミックス協会  2014.9 

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    Event date: 2014.9

    Language:Japanese  

    Venue:鹿児島大学   Country:Japan  

  • α-TCPフォーム顆粒を用いた連通気孔型骨セメントの創製

    都留 寛治, 石川 邦夫

    日本セラミックス協会  2014.9 

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    Event date: 2014.9

    Language:Japanese  

    Venue:鹿児島大学   Country:Japan  

  • Interconnected porous calcium phosphate forming cement consisting of α-TCP foam granules and calcium phosphate acidic solution. International conference

    2014.8 

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    Event date: 2014.8 - 2014.9

    Language:English  

    Venue:Liverpool   Country:United Kingdom  

  • Pre-osteoblast cell responses on phosphate and calcium co-immobilized titanium. International conference

    Sunarso, Toita Riki, Tsuru Kanji, Ishikawa Kunio

    European Society for Biomaterials,  2014.8 

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    Event date: 2014.8 - 2014.9

    Language:English  

    Country:United Kingdom  

  • Fabrication of carbonate apatite coated calcite and its in vivo evaluation. International conference

    Ishikawa Kunio, Tsuru Kanji, MUNAR MELVIN DE LEON, Masako Fujioka-Kobayashi, Youji Miyamoto

    European Society for Biomaterials  2014.8 

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    Event date: 2014.8 - 2014.9

    Language:English  

    Country:United Kingdom  

  • Fabrication and characterization of interconnected porous calcium phosphate forming cement consisting of α-TCP foam granules. International conference

    2014.8 

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    Event date: 2014.8

    Language:English  

    Country:Japan  

  • Fabrication and characterization of interconnected porous calcium phosphate forming cement consisting of α-TCP foam granules. International conference

    2014.8 

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    Event date: 2014.8

    Language:English  

    Venue:Fukuoka   Country:Japan  

  • In vitro biological properties of Ca-modified alumina prepared by hydrothermal treatment with calcium chloride. International conference

    Akari Takeuchi, Tarique Al-Mahmood Abullah, Tsuru Kanji, Ishikawa Kunio

    IUMRS-ICA2014  2014.8 

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    Event date: 2014.8

    Language:English  

    Country:Japan  

  • Effect of humidity on carbonation of calcium hydroxide. International conference

    Noriko Koga, Shunsuke Nomura, Tsuru Kanji, Ichiro Takahashi, Ishikawa Kunio

    The 15th IUMRS  2014.8 

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    Event date: 2014.8

    Language:English  

    Country:Japan  

  • Preparation of in vivo evaluation of beta-TCP bone replacement with fully interconnected pore similar to cancellous bone. International conference

    Tsuru Kanji, Taro Nikaido, MUNAR MELVIN DE LEON, Michito Maruta, Shigeki Matsuya, Seiji Nakamura, Ishikawa Kunio

    IUMRS-ICA2014  2014.8 

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    Event date: 2014.8

    Language:English  

    Country:Japan  

  • Fabrication of interconnected porous carbonate apatite from gypsum spheres. International conference

    Ishikawa Kunio, Shunsuke Nomura, Tsuru Kanji, Ichiro Takahashi

    2014.6 

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    Event date: 2014.6

    Language:English  

    Country:South Africa  

  • Development and characterization of porous calcium phosphate cement using α-tricalcium phosphate bead

    2015 

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    Event date: 2014.6

    Language:English  

    Venue:Ho Chi Minh City   Country:Viet Nam  

    Interconnected set porous-calcium phosphate cement (set porous-CPC), which has fully interconnected pores could be an ideal bone substitute. In this study, set porous- CPC consisting of α-tricalcium phosphate (α-TCP) beads and acidic calcium phosphate solution was developed and its basic setting reaction was studied. When α-TCP beads were exposed to the acidic calcium phosphate solution, brushite (CaHPO4 ·2H2O) was formed on the surface of the α-TCP beads. The formed brushite crystals interlocked with each other, resulting in a setting reaction of α-TCP microspheres within 10 min at 37°C. As a result of this setting reaction, a fullyinterconnected calcium phosphate macroporous structure was obtained. The set porous-CPC were immersed into simulated body fluid (SBF) at 37oC for different immersion time, The result clearly showed that brushite surface layer transformed to apatite layer after 3 days immersion into SBF solution by dissolution-precipitation reaction. Since apatite layer show excellent tissue response, the set porous-CPC would be a promising biomaterial used as artificial bone substitutes, and as the scaffold for tissue engineering.

  • Adsorption and desorption of FGF-2 from carbonate apatite granular. International conference

    Society for Biomaterials 2014 Annual Meeting & Exposition,  2014.4 

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    Event date: 2014.4

    Language:English  

    Country:United States  

  • Osteoconductive evaluation of alumina hydrothermally treated in CaCl2 aqueous solution. International conference

    Akari Takeuchi, A.A.-M Tarique, Tsuru Kanji, Ishikawa Kunio

    Society for Biomaterials 2014 Annual Meeting & Exposition  2014.4 

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    Event date: 2014.4

    Language:English  

    Country:United States  

  • バテライトとリン酸水素カルシウムを原料とした炭酸アパタイトセメントの創製

    都留 寛治, アリフ チャヤント, 戸井田 力, 丸田道人, 松家茂樹, 石川 邦夫

    第63回日本歯科理工学会学術講演会  2014.4 

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    Event date: 2014.4

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 炭酸アパタイトセメントの創製―基礎的性質の評価―

    石川 邦夫, 都留 寛治, 戸井田 力

    炭酸アパタイトセメントの創製―基礎的性質の評価―  2014.3 

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    Event date: 2014.3

    Language:Japanese  

    Country:Japan  

  • 炭酸アパタイトによる骨再生.

    石川 邦夫

    日本再生医療学会  2014.3 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都国際会議場   Country:Japan  

  • Three-dimensional porous carbonate apatite with sufficient mechanical strength as a bone substitute material

    Tram Nguyen Xuan Thanh, Michito Maruta, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

    11th International Fatigue Congress, FATIGUE 2014  2014 

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    Event date: 2014.3

    Language:English  

    Country:Australia  

  • Recent Advances and Invitation to Biomaterials research. International conference

    Ishikawa Kunio

    Biomaterials Seminar USM,  2014.2 

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    Event date: 2014.2

    Language:English  

    Country:Malaysia  

  • PLGA融合炭酸アパタイトフォームの組織反応.

    吉本彰夫, 石川 邦夫

    インプラント学会第33回関東・甲信越支部学術大会  2014.2 

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    Event date: 2014.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Biomaterials for Phase 3. Invited International conference

    Ishikawa Kunio

    The 6th AUN/SEED-Net Regional Conference on Materials Engineering.  2014.2 

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    Event date: 2014.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 整形・歯科領域コンビネーション製品の開発と評価―厚生労働省革新的医薬品・医療機器・再生医療製品実用化促進事業による検討―

    坂根 正孝, 澤田 賢則, 伊藤 敦夫, 柳 健一, 吉田 靖弘, 石川 邦夫, 橋本 幸一

    つくば医工連携フォーラム2014―医工連携による革新的医療機器の開発と産業化―  2014.1 

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    Event date: 2014.1

    Language:Japanese  

    Venue:つくば市   Country:Japan  

  • 炭酸アパタイト骨置換材の薬物修飾.

    石川 邦夫

    つくば医工連携フォーラム2014  2014.1 

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    Event date: 2014.1

    Language:Japanese  

    Venue:つくば市   Country:Japan  

  • Preparation of hydroxyapatite bead from gypsum waste and its ion-exchange ability for Sr2+. International conference

    Takuma Hikida, Akari Takeuchi, Masamoto Tafu, Ishikawa Kunio, Katsuya Teshima

    8th International Forum on Ecotechnology  2013.12 

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    Event date: 2013.12

    Language:English  

    Country:Japan  

  • Preliminary in vivo evaluation of three-dimensional porous carbonate apatite as a bone substitute. International conference

    Tram NXT, Maruta M, Tsuru Kanji, FUKUOKA DENTAL COLLEGE, Ishikawa Kunio

    The 13th Asian BioCeramics Symposium in conjunction with The 17th Symposium on Ceramics in Medicine, Biology and Biomimetics.  2013.12 

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    Event date: 2013.12

    Language:English  

    Country:Japan  

  • Carbonate apatite: Effect of PLGA composite on mechanical properties and tissue response. Invited International conference

    The 13th Asian BioCeramics Symposium in conjunction with The 17th Symposium on Ceramics in Medicine, Biology and Biomimetics.  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Fabrication of βTCP bone replacement with interconnected porous structure and it’s in vivo evaluation. International conference

    2013.12 

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    Event date: 2013.12

    Language:English  

    Venue:Kyoto   Country:Japan  

  • 低結晶性炭酸アパタイトの顎骨再建への応用に関する基礎的研究 第6報 BMP-2との併用効果

    石川 邦夫, 永井宏和, 原 香苗, 小林真左子, 藤澤健司, 都留 寛治, 山本克史, 宮本洋二

    第35回日本バイオマテリアル学会大会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 炭酸カルシウム球状粒子の作製

    姫野裕奈, 宮崎敏樹, 城崎由紀, 石川 邦夫

    第35回日本バイオマテリアル学会大会  2013.11 

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    Event date: 2013.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 連通多孔構造を有する炭酸アパタイト/PLGA複合体に関する基礎的研究

    太田 彰, 武知正晃, 太田耕司, Mohammad Zeshaan Rahman, 都留 寛治, 石川 邦夫, 鎌田伸之

    第35回日本バイオマテリアル学会大会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Synthesis of carbonate apatite foam using b-TCP foams as precursors. International conference

    Tsuru Kanji, Taro Nikaido, Melvin L. Munar, Michito Maruta, Shigeki Matsuya, Seiji Nakamura, Ishikawa Kunio

    25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (BIOCERAMICS 25),  2013.11 

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    Event date: 2013.11

    Language:English  

    Country:Romania  

  • Carbonate apatite bone replacement. International conference

    Ishikawa Kunio

    25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (BIOCERAMICS 25),  2013.11 

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    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Romania  

  • Ca表面修飾によるチタンの骨伝導性制御. Invited

    石川 邦夫

    東北大学金属材料研究所共同研究ワークショップおよび日本バイオマテリアル学会東北地域講演会  2013.10 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学金属材料研究所   Country:Japan  

  • PLGA の複合化による炭酸アパタイト連通多孔体の操作性改善

    都留 寛治, 戸井田 力, 石川 邦夫

    第49 回九大生体材料・力学研究会  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Fabrication and μCT evaluation of hierarchical carbonate apatite-PLGA foam. International conference

    2013.9 

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    Event date: 2013.9

    Language:English  

    Venue:Madrid   Country:Spain  

  • β型リン酸三カルシウムフォーム骨置換材の創製とin vitro評価

    都留 寛治, 二階堂太郎, 丸田道人, 松家茂樹, 中村 誠司, 石川 邦夫

    日本セラミックス協会第26回秋季シンポジウム  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:長野県   Country:Japan  

  • 自己硬化型炭酸アパタイトセメントの基礎的評価

    戸井田 力, Arief Cahyanto, 都留 寛治, 石川 邦夫

    日本セラミックス協会第26回秋季シンポジウム  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:長野県   Country:Japan  

  • 石膏球の硬化反応を利用した炭酸アパタイト連通多孔体の調製.

    石川 邦夫, 野村俊介, 都留 寛治

    日本セラミックス協会第26回秋季シンポジウム  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Country:Japan  

  • 炭酸アパタイト顆粒へのFGF吸着挙動

    吉田貴子, 戸井田 力, 都留 寛治, 石川 邦夫

    日本セラミックス協会第26回秋季シンポジウム  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:長野県   Country:Japan  

  • FGF-2複合化炭酸アパタイトの作製とその特性解析

    吉田貴子, 戸井田 力, 都留 寛治, 石川 邦夫

    平成25年度日本歯科理工学会九州地方会夏期セミナー  2013.8 

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    Event date: 2013.8

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • ガン細胞シグナル応答型遺伝子キャリヤーの開発

    戸井田 力, 片山 佳樹, 石川 邦夫

    平成25年度日本歯科理工学会九州地方会夏期セミナー  2013.8 

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    Event date: 2013.8

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • Fabrication and in vivo study of βTCP foam with fully interconnected porous structure for bone replacement. International conference

    2013.8 

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    Event date: 2013.8

    Language:English  

    Venue:Bangkok   Country:Thailand  

  • Fabrication of β-TCP foam based on thermal treatment of α-TCP foam and its tissue response. International conference

    2013.6 

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    Event date: 2013.6

    Language:English  

    Venue:Hong Kong  

  • Ca salt introduction to improve the mechanical strength of carbonate apatite block. International conference

    Jane HARLAND, Tsuru Kanji, Michto Maruta, Ishikawa Kunio

    4th Asian Biomaterials Congress.  2013.6 

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    Event date: 2013.6

    Language:English  

  • Fabrication of interconnected porous carbonate apatite from gypsum spheres. International conference

    Ishikawa Kunio, Shunsuke Nomura, Tsuru Kanji

    6th International symposium on apatite and correlative biomaterials.  2013.6 

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    Event date: 2013.6

    Language:English  

    Country:France  

  • Carbonate apatite cement consisting of vaterite and dicalcium phosphate anhydrous transforms to carbonate apatite. International conference

    Arief Cahyanto, Michito Maruta, Tsuru Kanji, Shigeki Matsuya, Ishikawa Kunio

    The 10th Pacific Rim Conference on Ceramic and Glass Technology, 2013  2013.6 

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    Event date: 2013.6

    Language:English  

    Country:United States  

  • 海綿骨形態に類似したβ 型リン酸三カルシウム骨補填材の調製とその評価

    二階堂太郎, 都留 寛治, 川内義一郎, 中村 誠司, 石川 邦夫

    第67回日本口腔科学会学術集会  2013.5 

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    Event date: 2013.5

    Language:Japanese  

    Venue:栃木県総合文化センター   Country:Japan  

  • Basic properties of starfish bone and its phase transformation reaction in phosphate salt solution. International conference

    Akari Takeuchi, Daiki Honda, Ishikawa Kunio

    Society for Biomaterials 2013 Annual Meeting & Exposition  2013.4 

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    Event date: 2013.4

    Language:English  

    Country:United States  

  • Effects of Coating Method on PLGA-Reinforced Carbonate Apatite Foam. International conference

    Ishikawa Kunio, Munar GM, Munar ML, Tsuru Kanji

    2013 IADR General Session& Exhibition  2013.3 

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    Event date: 2013.3

    Language:English  

    Country:United States  

  • 炭酸アパタイトセメントの創製―基礎的性質の評価―

    都留 寛治, アリフチャヤント, 戸井田 力, 石川 邦夫, 丸田道人, 松家茂樹

    日本セラミックス協会2014年年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 硬組織再建材料の科学 Invited

    石川 邦夫

    香川大学インプラント研究会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:香川大学   Country:Japan  

  • Bioceramics for medical application. Invited International conference

    Ishikawa Kunio

    The symposium on Recent Progress on Tissue Enginnering  2013.2 

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    Event date: 2013.2

    Language:English  

    Country:Indonesia  

  • 炭酸アパタイトフォーム骨置換材:PLGAとの融合化

    吉本彰夫、石川邦夫

    第32回 関東・甲信越支部学術大会  2013.2 

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    Event date: 2013.2

    Language:Japanese  

    Venue:京王プラザホテル、東京   Country:Japan  

  • Hydrothermal conversion of calcite foam to carbonate apatite

    N. X T Tram, M. Maruta, K. Tsuru, S. Matsuya, Kunio Ishikawa

    Advances in Bioceramics and Porous Ceramics VI - 37th International Conference on Advanced Ceramics and Composites, ICACC 2013  2014 

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    Event date: 2013.1 - 2013.2

    Language:English  

    Country:United States  

  • Bone marrow cell response on carbonate apatite/PCL-coated α-tricalcium phosphate foam

    2014 

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    Event date: 2013.1

    Language:English  

    Country:Malaysia  

    The aim of this research work was to investigate in vitro effect of the carbonate apatite/poly(ε- caprolactone) (CO3Ap/PCL) on α-tricalcium phosphate (α-TCP) foam. α-TCP was produced by sintering CaCO3 and CaHPO4•2H2O at 1500°C for 5 h. It was then coated with CO3Ap/PCL (wt/wt=1/3) to improve both mechanical and biological properties. The initial cell attachment and proliferation of the bone marrow cells were carried out on the α-TCP and CO3Ap/PCL-coated α- TCP foams. The cell proliferation was calculated by AlamarBlue assay. The cells were able to migrate and proliferate well on both α-TCP and CO3Ap/PCL-coated α-TCP foams indicating an excellent biocompatibility. The incorporation of CO3Ap on the coating layer improved cellular attachment and accelerated proliferation. Thus, CO3Ap/PCL-coated α-TCP foam might be a promising candidate as implant material.

  • Tricalcium phosphate for bone defect reconstruction. Invited International conference

    Ishikawa Kunio

    The 5th AUN/SEEDNet Regional Conference on Materials Engineering & The 5th Regional Conference on Natural Resources and Materials  2013.1 

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    Event date: 2013.1

    Language:English  

    Country:Malaysia  

  • Tricalcium phosphate for bone defect reconstruction. Invited International conference

    Ishikawa Kunio

    The 5th AUN/SEEDNet Regional Conference on Materials Engineering & The 5th Regional Conference on Natural Resources and Materials.  2013.1 

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    Event date: 2013.1

    Language:English  

    Country:Malaysia  

  • Study on the sintering of -TCP bioceramics by conventional and microwave sintering. International conference

    2013.1 

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    Event date: 2013.1

    Language:English  

    Venue:Park Royal Hotel, Penang,   Country:Malaysia  

  • Bone marrow cell response on carbonate apatite/PCL coated -TCP foam. International conference

    2013.1 

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    Event date: 2013.1

    Language:English  

    Venue:Park Royal Hotel, Penang,   Country:Malaysia  

  • 埋植型薬剤組み合わせ医療機器の評価方法確立のための調査研究―品目の定義と機能的分類―

    柳健一、伊藤敦夫、吉田靖弘、石川邦夫、重藤和弘、橋本幸一、坂根正孝

    第50回日本人工臓器学会大会  2012.11 

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    Event date: 2012.11

    Language:Japanese  

    Venue:アクロス福岡、福岡   Country:Japan  

  • アパタイトの科学 Invited

    石川 邦夫

    日本口腔院プラント学会第32会中国・四国支部総会・学術大会  2012.11 

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    Event date: 2012.11

    Language:Japanese  

    Venue:総合あんしんセンター、高知   Country:Japan  

  • Bioceramics for medical application. Invited International conference

    Ishikawa Kunio

    Tissue Enginnering Seminer.  2012.11 

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    Event date: 2012.11

    Language:English  

    Country:Indonesia  

  • Fabrication of spherical carbonate apatite using calcium sulfate as a precursor by W/O emulsion method

    Shunsuke Nomura, Kanji Tsuru, Shigeki Matsuya, Ichiro Takahashi, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Fabrication of calcite foam by inverse ceramic foam method

    Tram Nguyen Xuan Thanh, Michito Maruta, Kanji Tsuru, Alireza Valanezhad, Shigeki Matsuya, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Effects of hydrothermal treatment on properties of titanium nitride coating for dental implants

    Xingling Shi, Kanji Tsuru, Giichiro Kawachi, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Comparison of PLGA reinforcement method for carbonate apatite foam

    Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Basic properties of starfish derived calcium carbonate and its phase transformation to carbonate apatite

    Daiki Honda, Akari Takeuchi, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Basic properties of carbonate apatite cement consisting of vaterite and dicalcium phosphate anhydrous

    Arief Cahyanto, Michito Maruta, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Protectivity and adhesive strength of zinclipscombite coating on 316L stainless steel

    Alireza Valanezhad, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa

    24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012  2013 

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    Event date: 2012.10

    Language:English  

    Country:Japan  

  • Preparation of carbonate apatite cement based on α-TCP

    2013 

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    Event date: 2012.10

    Language:English  

    Venue:Fukuoka   Country:Japan  

    Carbonate apatite showed an excellent bioresorbability through the remodeling process of bone. In the present study, we prepared self-setting carbonate apatite cement based on α-TCP. We tried two types of the cement powder formulations, that is, first one (F1) is α-TCP containing given amounts (10 to 50 mass%) of synthesized carbonate apatite and second one (F2) is α-TCP treated in 0.5M NaHCO3 for various times between 90 and 360 min. The cement powder was mixed with 0.25M Na2HPO4 to allow set at 37°C and 100% of relative humidity up to 1 day. XRD and FT-IR results showed formation of B-type carbonate apatite phase after setting in both of the formulations. With the formulation, F1, the carbonate content was increased with the treatment time and the maximum content was 4.1 mass%. DTS deacreased with the amount of cabonate apatite in the formulation, F1, however, it increased up to 9 MPa with treatment time in the formulation, F2.

  • Improvement in handling property of αTCP cement

    2013 

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    Event date: 2012.10

    Language:English  

    Venue:Fukuoka   Country:Japan  

    This study aims to improve the handling property of alpha-tricalcium (αTCP) cement. In order to improve the handling property, the effect of γ-poly-glutamic acid (γPGA) as a chelating agent was studied. γPGA is water soluble, biodegradable, nontoxic, and edible material. γPGA contains carboxyl group, so the chelating effect between Ca 2+ ions released from calcium phosphate cement and carboxyl group of γPGA is prospected when it mixed with αTCP based cement. The results obtained in this study clearly demonstrated that the addition of γPGA into the αTCP cement was highly effective in controlling the handling property of αTCP cement.

  • Fabrication of βTCP foam using αTCP foam as a precursor by heat treatment

    2013 

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    Event date: 2012.10

    Language:English  

    Venue:Fukuoka   Country:Japan  

    The present study reports the synthesis of βTCP foam with fully interconnecting pores based on phase transformation of αTCP foam precursor by employing heat treatment. First, the αTCP foam precursor was fabricated by sintering the ceramics slurry-coated polyurethane foam template at 1,500°C. The resultant αTCP foam was again heated below α,βtransition temperature for an extended period of times. After heating at 800°C for 150 hours, 900°C for 100 hours and 1,000°C for 300 hours, βTCP foam was obtained. The compressive strength of βTCP foam was approximately 46 kPa and the porosity was approximately 93%. The long heating period as well as heating temperature were the key to the transformation of βTCP phase. βTCP foam could be an ideal bone replacement since the invasion of bone cells into the pores provides optimum bone growth or repair.

  • α-リン酸三カルシウム型アパタイトセメントの基礎的物性に及ぼすアパタイト種結晶導入方法の影響

    都留寛治、石川邦夫、Ruslin、丸田道人、松家茂樹

    日本セラミックス協会第25回秋期シンポジウム  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:名古屋大学、名古屋   Country:Japan  

  • PLGA-炭酸アパタイト融合フォーム調製における真空浸漬の影響

    石川邦夫、都留寛治、Munar Girlie、Munar Melvin

    日本セラミックス協会第25回秋期シンポジウム  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:名古屋大学、名古屋   Country:Japan  

  • 炭酸アパタイト骨置換材 Invited

    石川 邦夫

    第10回医療機器フォーラム  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:長井記念ホール、東京   Country:Japan  

  • 埋植型薬剤組み合わせ医療機器の評価方法確立のための調査研究―第1報研究計画―

    柳健一、伊藤敦夫、吉田靖弘、石川邦夫、重藤和弘、橋本幸一、坂根正孝

    第2回レギュラトリーサイエンス学会学術大会  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:学術総合センター、東京   Country:Japan  

  • Carbonate apatite foam bone replacement. Invited International conference

    Ishikawa Kunio

    2012.8 

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    Event date: 2012.8 - 2012.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Romania  

  • Carbonate apatite bone replacement. Invited International conference

    Ishikawa Kunio

    Ho Chi Minh City High Tech Park Lecture  2012.8 

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    Event date: 2012.8

    Language:English  

    Country:Viet Nam  

  • Carbonate apatite bone replacement. Invited International conference

    Ishikawa Kunio

    Ho Chi Minh City University of Technology Biomaterials Symposium  2012.8 

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    Event date: 2012.8

    Language:English  

    Country:Viet Nam  

  • Biological evaluations of carbonate apatite and silicon-substituted carbonate apatite: MC3T3-E1 osteoblast cell-like study International conference

    Le Thi Bang, Kunio Ishikawa, Radzali Othman

    International Conference of Young Researchers on Advanced Materials  2012.7 

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    Event date: 2012.7

    Language:English  

    Country:Singapore  

  • Fully-interconnected pore forming calcium phosphate cement. 90th General Session & Exhibition of the International Association for Dental Research International conference

    Ishikawa Kunio

    Iguacu Falls  2012.6 

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    Event date: 2012.6

    Language:English  

    Country:Brazil  

  • 炭酸アパタイトPLGA複合フォームの創製

    石川邦夫, 都留寛二, Munar Girlie, Munar Melvin

    日本再生医療学会  2012.6 

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    Event date: 2012.6

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • PLGA-炭酸アパタイトフォーム階層化における真空浸漬の影響

    石川邦夫

    新学術領域(融合マテリアル)第5回公開シンポジウム  2012.6 

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    Event date: 2012.6 - 2011.6

    Venue:慶応大学(神奈川)   Country:Japan  

  • Ozone Treatment Improves Handling and Mechanical Properties of Apatite Cement. International conference

    Kunio Ishikawa, Ira Artilia, Michito Maruta, Kanji Tsuru.

    9th World Biomaterials Congress.  2012.6 

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    Event date: 2012.6 - 2011.6

    Country:China  

  • Hydroxyapatite Coating on Zinc Phosphatized Titanium. International conference

    Alireza Valanezhad, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa.

    9th World Biomaterials Congress.  2012.6 

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    Event date: 2012.6 - 2011.6

    Country:China  

  • Reinforcement of carbonate apatite foam by coating with poly-L-lactic acid containing carbonate apatite granules. International conference

    Kanji Tsuru, Girlie M. Munar, Melvin L. Munar, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa.

    9th World Biomaterials Congress.  2012.6 

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    Event date: 2012.6 - 2011.6

    Country:China  

  • 第二リン酸カルシウムと炭酸カルシウムを出発原料とした炭酸アパタイトブロックの骨伝導能評価

    大東文和,都留寛治,石川邦夫,寺田善博

    (社)日本補綴歯科学会第121回学術大会  2012.5 

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    Event date: 2012.5 - 2011.5

    Venue:神奈川県民ホール/産業貿易センタービル   Country:Japan  

  • 骨リモデリングサイクルに適合して吸収される炭酸含有アパタイト Invited

    石川邦夫

    第85回日本整形外科学会学術総会  2012.5 

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    Event date: 2012.5 - 2011.5

    Venue:国立京都国際会館、グランドプリンスホテル京都   Country:Japan  

  • Sr含有炭酸アパタイトのin vitro評価

    酒井亜希子、バラネザハド・アリゼラ、尾崎正雄、丸田道人、石川邦夫、松家茂樹

    第59回日本歯科理工学会学術講演会.  2012.4 

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    Event date: 2012.4 - 2011.4

    Venue:あわぎんホール、徳島   Country:Japan  

  • α-リン酸三カルシウム型アパタイトセメントの硬化時間に及ぼすアパタイト結晶核の添加方法の影響

    都留寛治,ラスリン,丸田道人,松家茂樹,石川邦夫

    第59回日本歯科理工学会学術講演会.  2012.4 

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    Event date: 2012.4 - 2011.4

    Venue:あわぎんホール、徳島   Country:Japan  

  • αTCP フォームを前駆体として用いた βTCP フォームの調製

    二階堂太郎、都留寛治、川内義一郎、松家茂樹、中村誠司、石川邦夫

    第59回日本歯科理工学会学術講演会.  2012.4 

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    Event date: 2012.4 - 2011.4

    Venue:あわぎんホール、徳島   Country:Japan  

  • Comparison of β-tricalcium phosphate foam made using Mg stabilizer and by heat treatment. International conference

    2013.4 

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    Event date: 2012.4 - 2013.4

    Language:English  

    Venue:Boston, MA,   Country:United States  

  • PLGA階層化炭酸アパタイトフォームの創製.

    石川邦夫

    融合マテリアル分子制御による材料創成と機能開拓第4回公開シンポジウム  2012.1 

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    Event date: 2012.1 - 2011.1

    Venue:大阪大学中之島センター   Country:Japan  

  • Effect of precursor solubility on the mechanical strength of HAp block

    Nurazreena Ahmad, Kami Tsuru, Melvin L. Munar, Shigeki Matsuya, Kunio Ishikawa

    Advances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012  2013.4 

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    Event date: 2012.1

    Language:English  

    Country:United States  

  • Fabrication of carbonate apatite-PLGA hybrid foam bone substitute

    Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

    Advances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012  2013 

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    Event date: 2012.1

    Language:English  

    Country:United States  

  • Carbonate apatite formation during the setting reaction of apatite cement

    Arief Cahyanto, Kanji Tsuru, Kunio Ishikawa

    Advances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012  2013 

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    Event date: 2012.1

    Language:English  

    Country:United States  

  • Fabrication of Carbonate Apatite–PLGA Hybrid Foam Bone Substitute. International conference

    2012.1 

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    Event date: 2012.1

    Venue:Hilton Daytona Beach Resort and Ocean Center   Country:United States  

  • Fabrication of Monophasic HAp Discs from Tricalcium Phosphate by Hydrothermal Treatment in Ammonia Solution. International conference

    Nurazreena Ahmad, Kanji Tsuru, Melvin L. Munar, Shigeki Matsuya, Kunio Ishikawa

    36th International Conference and Exposition on Advanced Ceramics and Composites.  2012.1 

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    Event date: 2012.1 - 2011.1

    Country:United States  

  • Carbonate Apatite Formation During The Setting Reaction of Apatite Cement. International conference

    Arief Cahyanto, Kanji Tsuru, Kunio Ishikawa

    36th International Conference and Exposition on Advanced Ceramics and Composites.  2012.1 

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    Event date: 2012.1 - 2011.1

    Country:United States  

  • Modification of Titanium Surface with Hydroxyapatite and Calciumt. Invited International conference

    Kunio Ishikawa

    4th Regional conference on high performance materials  2011.12 

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    Event date: 2011.12

    Country:Viet Nam  

  • Fabrication of carbonate apatite block from calcium sulfate by hydrothermal treatment

    Shunsuke Nomura, Kanji Tsuru, Alireza Valanezhad, Shigeki Matsuya, Ichiro Takahashi, Kunio Ishikawa

    23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011  2012.1 

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    Event date: 2011.11

    Language:English  

    Country:Turkey  

  • Fully-interconnected pore forming calcium phosphate cement

    Kunio Ishikawa, Kanji Tsuru, Trung Kien Pham, Michito Maruta, Shigeki Matsuya

    23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011  2012 

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    Event date: 2011.11

    Language:English  

    Country:Turkey  

  • Fabrication of βtcp with fully-interconnected porous structure

    2012 

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    Event date: 2011.11

    Language:English  

    Venue:Istanbul   Country:Turkey  

    Calcium phosphate foam could be an ideal bone filler and scaffold for tissue engineering. This paper describes fabrication method of β-tricalcium phosphate (βTCP) foam with fully-interconnected porous structure by employing magnesium oxide (MgO) as βTCP stabilizer. The foam was prepared using the so-called ceramics foam method. MgO was added to calcium carbonate and dicalcium phosphate dihydrate so that 0, 1, 2, 3, 4, 6 and 8 mol% calcium would be substituted by magnesium (Mg) in βTCP structure. After sintering at 1500°C, crystal phase of the obtained foam included β-tricalcium phosphate (αTCP) when no Mg or less than 3 mol% Mg was added. In contrast, crystal phase was single phase βTCP when 3 mol% or higher Mg was added. The compressive strength was approximately 15 kPa and the porosity was above 95% for all specimens. No significant difference was observed between αTCP and βTCP foams in compressive strength and porosity when the sintering temperature was the same.

  • Calcite bone substitute prepared from calcium hydroxide compact using heat-treatment under carbon dioxide atmosphere

    Kanji Tsuru, Akihiro Otsu, Michito Maruta, Alireza Valanezhad, Giichiro Kawachi, Akari Takeuchi, Shigeki Matsuya, Kunio Ishikawa

    23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011  2012 

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    Event date: 2011.11

    Language:English  

    Country:Turkey  

  • A novel HAp coating method on titanium

    Aireza Valanezhad, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa

    23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011  2012 

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    Event date: 2011.11

    Language:English  

    Country:Turkey  

  • Fabrication of Carbonate Apatite Block from Calcium Sulfate by Hydrothermal Treatment. International conference

    Shunsuke Nomura, Kanji Tsuru, Alireza Valanezhad, Shigeki Matsuya, Ichiro Takahashi, Kunio Ishikawa

    Bioceramics23  2011.11 

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    Event date: 2011.11

    Country:Turkey  

  • Fully-Interconnected Pore Forming Calcium Phosphate Cement International conference

    Kunio Ishikawa, Kanji Tsuru, TrungKien Pham, Michito Maruta, ShigekiMatuya

    Bioceramics23  2011.11 

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    Event date: 2011.11

    Country:Turkey  

  • Fabrication of βTCP with Fully-Interconnected Porous Structure International conference

    2011.11 

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    Event date: 2011.11

    Venue:Ceylan Intercontinental Istanbul Hotel   Country:Turkey  

  • Calcite Bone Substitute Prepared From Calcium Hydroxide Compact Using Heat-Treatment Under Carbon Dioxide Atmosphere. International conference

    Kanj Tsuru, Akihiro Otsu, Michito Maruta, AlirezaValanezhad,GiichiroKawachi, Akari Takeuchi, Shigeki Matsuya,Kunio Ishikawa

    Bioceramics23  2011.11 

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    Event date: 2011.11

    Country:Turkey  

  • A novel HAp coating method on titanium. International conference

    Alireza Valanezhad, Kanji Tsuru, MichitoMaruta, Shigeki Matsuya, Kunio Ishikawa

    Bioceramics23  2011.11 

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    Event date: 2011.11

    Country:Turkey  

  • Modification of Titanium Surface with Hydroxyapatite and Calciumt. Invited International conference

    Kunio Ishikawa

    4th Regional conference of natural resources and materials  2011.10 

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    Event date: 2011.10

    Country:Philippines  

  • 前駆体としてカルサイトを用いた中実および中空炭酸アパタイト球状骨置の創製.

    須ノ内一広、都留寛治、丸田道人、川内義一郎、松家茂樹、寺田善博、石川邦夫

    第58回日本歯科理工学会学術講演会  2011.10 

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    Event date: 2011.10

    Venue:奥羽大学歯学部   Country:Japan  

  • 焼結炭酸カルシウムを前駆体として用いた骨補填材の創製.

    大津亮泰、都留寛治、丸田道人、バラネザハド アリレザ、松家茂樹、石川邦夫

    第58回日本歯科理工学会学術講演会  2011.10 

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    Event date: 2011.10

    Venue:奥羽大学歯学部   Country:Japan  

  • Biomaterials for reconstruction of bone defect. The symposium on Recent Progress on Bone Graft and its Relevance in Dental Clinics Invited International conference

    Kunio Ishikawa

    2011.10 

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    Event date: 2011.10

    Country:Indonesia  

  • Surface modification of polyethylene terephtalate (PET) by ozone-calcium chloride (O3-CaCl2) treatment: chemical characterization and biological assessment. International conference

    Ahmed Rashid, Masaharu Nakagawa, Kanji Tsuru, Giichiro Kawachi, Kunio Ishikawa

    The 3rd Asian Biomaterials Congress  2011.9 

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    Event date: 2011.9

    Country:Korea, Republic of  

  • Interconnected porous cement from a-tricalcium phosphate microsphres. International conference

    Trung Kien Pham, Michito Maruta, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

    The 3rd Asian Biomaterials Congress  2011.9 

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    Event date: 2011.9

    Country:Korea, Republic of  

  • Reinforcement of carbonate apatite bone replacement with carbonate apatite by Ca salt introduction. International conference

    Kunio Ishikawa, Kanako Matsumoto, Kanji Turu, Ichiro Takahashi

    The 3rd Asian Biomaterials Congress  2011.9 

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    Event date: 2011.9

    Country:Korea, Republic of  

  • Hydroxyapatite coating on titanium via titanium zinc phosphate layer

    Kunio Ishikawa, Alireza Valanezhad, Kanji Tsuru

    24th European Conference on Biomaterials, EBS 2011  2011 

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    Event date: 2011.9

    Language:English  

    Country:Ireland  

  • Hydroxyapatite coating on titanium via titanium zinc phosphate layer. International conference

    Kunio Ishikawa, Michito Maruta, Shigeki Matsuya, Kanji Tsuru

    2011.9 

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    Event date: 2011.9

    Country:Ireland  

  • Hydroxyapatite coating on titanium via titanium zinc phosphate layer. International conference

    Kunio Ishikawa, Michito Maruta, Shigeki Matsuya, Kanji Tsuru

    2011.9 

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    Event date: 2011.9

    Country:Ireland  

  • Hydroxyapatite coating on titanium via titanium zinc phosphate layer. International conference

    Kunio Ishikawa, Michito Maruta, Shigeki Matsuya, Kanji Tsuru

    2011.9 

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    Event date: 2011.9

    Country:Ireland  

  • Fabrication of CO3Ap foam bone replacement from sintered calcite foam. Invited International conference

    Kunio Ishikawa, Michito Maruta, Shigeki Matsuya, Kanji Tsuru

    PacRim9 (The 9th International Meeting of Pacific Rim Ceramic Societies).  2011.7 

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    Event date: 2011.7

    Country:Australia  

  • Fabrication of βTCP foam using magnesium oxide as a stabilizer. International conference

    2011.5 

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    Event date: 2011.5

    Country:Korea, Republic of  

  • In vitro and in vivo evaluation of Ca-modified titanium with Ca-ozone treatment. International conference

    Kanji Tsuru, Mami Sakaguchi, Yasunori Ayukawa, Yasuko Moriyama, Michito Maruta, Shigeki Matsuya, Kiyoshi Koyano, Kunio Ishikawa

    International Dental Materials Congress 2011.  2011.5 

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    Event date: 2011.5

    Country:Korea, Republic of  

  • Effects of granular size on the tissue response to carbonate apatite granules in rabbit. International conference

    Kunio Ishikawa, Youji Miyamoto, Kenji Fujisawa, Hirokazu Nagai, Kanji Tsuru, Michito Maruta, Shigeki Matsuya

    International Dental Materials Congress 2011.  2011.5 

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    Event date: 2011.5

    Country:Korea, Republic of  

  • In vitro evaluation of osteoclastic resorption on carbonate apatite block derived from dicalcium phosphate and calcium carbonate. International conference

    Fumikazu Daitou, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Yoshihiro Terada, Kunio Ishikawa

    International Dental Materials Congress 2011.  2011.5 

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    Event date: 2011.5

    Country:Korea, Republic of  

  • Preparation of porous calcium phosphate cement from preparation of porous calcium phosphate cement from α-TCP balls. International conference

    2011.4 

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    Event date: 2011.4

    Country:United States  

  • 骨に学ぶ~炭酸アパタイト骨置換材の創製 Invited

    石川邦夫

    バイオマテリアル学会九州ブロックキックオフシンポジウム  2011.3 

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    Event date: 2011.3

    Presentation type:Oral presentation (general)  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • アパタイトセメントの変遷 Invited

    石川邦夫

    相澤「次世代バイオセラミックス」プロジェクト 「2010年度 第2回 勉強会」  2011.2 

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    Event date: 2011.2

    Presentation type:Oral presentation (general)  

    Venue:神奈川科学技術アカデミー   Country:Japan  

  • Shape forming based on dissolution-precipitation reaction. Invited International conference

    Kunio Ishikawa

    5th International Symposium on Apatites and Correlative Biomaterials  2010.12 

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    Event date: 2010.12

    Country:Austria  

  • Effect of reaction time on setting property of α-tricalcium phosphate (α -TCP) balls. International conference

    2010.12 

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    Event date: 2010.12

    Country:Austria  

  • Electrophoretic deposition of low-crystalline apatite on quartz substrate. International conference

    M. Kawashita1, K. Taninai1, K. Ishikawa2 and Y. Yoshida

    5th International Symposium on Apatites and Correlative Biomaterials  2010.12 

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    Event date: 2010.12

    Country:Austria  

  • Carbonate apatite foam bone substitute reinforced with PLGA for mechanical strenght improvement. International conference

    Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

    5th International Symposium on Apatites and Correlative Biomaterials  2010.12 

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    Event date: 2010.12

    Country:Austria  

  • Surface modification of polyethylen terephthalate (PET) substrates for biomedical application by ozone-calcium chloride treatments. International conference

    Ahmed Nafis Rashid, Kanji Tsuru, Giichiro Kawachi, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa

    5th International Symposium on Apatites and Correlative Biomaterials  2010.12 

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    Event date: 2010.12

    Country:Austria  

  • DCPAとCaCO3を原料とした炭酸アパタイトブロックのin vitro破骨細胞吸収性.

    大東文和、丸田道人、川内義一郎、都留寛治、松家茂樹、寺田善博、石川邦夫

    第14回生体関連セラミックス討論会  2010.12 

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    Event date: 2010.12

    Venue:京都テルサ   Country:Japan  

  • CaCl2水溶液を用いて水熱処理した金属チタンの細菌付着性.

    高本 愛、武知正晃、太田耕司、鎌田伸之、都留寛治、石川邦夫、峯 裕一、高木祐子、二川浩樹

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:グランドプリンスホテル広島   Country:Japan  

  • 炭酸アパタイトによる骨再生

    石川邦夫

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Venue:グランドプリンスホテル広島   Country:Japan  

  • GM含有α―TCP/ACの顎骨骨髄炎への応用に関する基礎的研究-基本物性と骨形成評価について-.

    二宮嘉昭、武知正晃、太田耕司、南 正彦、多田美里、太田 彰、湯浅哲也、石川邦夫、鎌田伸之

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:グランドプリンスホテル広島   Country:Japan  

  • 低結晶性炭酸アパタイトの顎骨再建への応用に関する基礎的研究

    湯浅哲也、藤澤健司、永井宏和、大江 剛、佐藤裕子、池村光代、山本克史、都留寛治、石川邦夫、宮本洋二

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:グランドプリンスホテル広島   Country:Japan  

  • Macroporous calcium phosphate cement: Setting reaction and initial mechanical strength, Invited International conference

    Kunio Ishikawa

    3rd International Congress on Ceramics.  2010.11 

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    Event date: 2010.11

    Country:Japan  

  • Apatite coatings onto quartz substrate using self-assembled monolayer. International conference

    Taninai K, Kawashita M, Ishikawa K, Yoshida Y

    The 10th Asian BioCeramics Symposium  2010.11 

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    Event date: 2010.11

    Country:Indonesia  

  • Osteoclastic resorption of carbonate apatite block prepared from DCPD and CaCO3. International conference

    Fumikazu Daiou, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Yoshihiro Terada, Ishikawa K

    The 10th Asian BioCeramics Symposium  2010.11 

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    Event date: 2010.11

    Country:Indonesia  

  • Improvement of handling property of apatite cement paste by O3 treatment. International conference

    Artilia I, Maruta M, Kawachi G, Tsuru K, Ishikawa K

    The 10th Asian BioCeramics Symposium  2010.11 

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    Event date: 2010.11

    Country:Indonesia  

  • Effect of distilled water treatment on the initial setting time of a-tricalcium phosphate. International conference

    Ruslin, Michito Maruta, Kanji Tsuru, Giichiro Kawachi, Shigeki Matsuya, Kunio Ishikawa

    The 10th Asian BioCeramics Symposium  2010.11 

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    Event date: 2010.11

    Country:Indonesia  

  • Bone engineering. Invited International conference

    Kunio Ishikawa

    One day workshop on tissue engineering  2010.11 

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    Event date: 2010.11

    Country:Indonesia  

  • Zinc phosphate coating on titanium and its cell response. European Biomaterials Society International conference

    Kunio Ishikawa, A. Valanezhad Alireza, Kanji Tsuru

    European Biomaterials Society  2010.9 

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    Event date: 2010.9

    Country:Finland  

  • Synthesis and characterization of carbonate apatite through internal dissolution-precipitation reaction. International conference

    Fumikazu. Daitou, Michito Maruta, Giichiro Kawachi, Kanji Tsuru, Yoshihiro Terada, Kunio Ishikawa, Shigeki Matsuya

    IADR General Session  2010.7 

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    Event date: 2010.7

    Country:Spain  

  • A novel rich-phosphate coating on ziroconia with high bonding to surface. International conference

    Valanezhad Alireza, Kanji Tusru, Michito Maruta, Giichiro Kawachi, Shigeki Matsuya, Kunio Ishikawa

    CIMTEC2010; 5th Forum on New Materials; 9th International Conference Medical Applications of Novel Biomaterials and Nano-biotechnology  2010.7 

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    Event date: 2010.7

    Country:Italy  

  • Nanocrystalline carbonate apatite fabrication based on chemical conversion from calcium carbonate. International conference

    Kunio Ishikawa

    CIMTEC2010; 5th Forum on New Materials; 9th International Conference Medical Applications of Novel Biomaterials and Nano-biotechnology  2010.6 

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    Event date: 2010.6

    Country:Italy  

  • Effects of Ca-ozone treatment on initial cell attachment to titanium International conference

    Kunio Ishikawa, Mami Sakaguchi, Kanji Tsuru, Giichiro Kawachi, Michito Maruta, Kiyoshi Koyano

    2010 Annual meeting & Exposition Society For Biomaterials  2010.4 

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    Event date: 2010.4

    Country:United States  

  • カルシウム塩導入による炭酸アパタイト骨補填材の機械的強さ向上

    松元歌奈子、都留寛治、川内義一郎、丸田道人、松家茂樹、高橋一郎、石川邦夫

    第55回日本歯科理工学会学術講演会  2010.4 

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    Event date: 2010.4

    Country:Japan  

  • 骨に学ぶ:骨再建材料 Invited

    石川邦夫

    日本歯科先端技術研究所 「骨」を考える  2010.3 

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    Event date: 2010.3

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Synthesis and in vitro cell compatibility of α-tricalcium phosphate-based apatite cement containing tricalcium silicate

    2010 

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    Event date: 2010.1

    Language:English  

    Venue:Ho Chi Minh City   Country:Viet Nam  

    The presence of silicate in artificial bone graft material is known to be effective in increasing bone formation rate. We previously reported the basic setting properties of α-tricalcium phosphate (α-Ca 3PO4; α-TCP) based apatite cement (AC) with various amount of tricalcium silicate (Ca3SiO5; alite) addition using sodium dihydrogen phosphate (NaH2PO4) as the liquid phase. In this study, in vitro biological compatibility of pure α-TCP and 2.5-10.0 wt% alite added to α-TCP based AC is investigated in terms of cell attachment, proliferation and differentiation. Set ACs aged for 168 hrs were used for cell studies with bone marrow cells from tibia of 4 week-old, male, SD rat. Initial cell attachment was observed after 7 hrs; cell proliferation was observed after 3, 5, and 7 days. Cell differentiation (alkaline phosphatase activity) was observed after 3, 6, and 9 days of incubation. Cell attachment of alite added ACs were almost the same as sintered hydroxyapatite (HAp) and alite-free AC. Cell proliferation at 2.5-7.5 wt% alite added ACs were significantly higher at day 5 and 7 (p<0.05). Alkaline phosphatase activity revealed that 2.5 wt% alite addition accelerated the osteogenic cell activity at day 6 and 9 (p<0.05) whereas too much alite addition resulted in the decrease of osteogenic cell activity. In conclusion, we found that α-TCP based AC containing appropriate amount of alite could be an improved AC since it shows suitable setting time, higher mechanical strength and possible higher osteoconductivity.

  • Hydrothermal surface modification with calcium Invited International conference

    Kunio Ishikawa

    The 2nd International Symposium on Surface and Interface of Biomaterials  2010.1 

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    Event date: 2010.1

  • Electrophoertic deposition of bone-like apatite onto quartz substrate International conference

    K. Taninai, M. Kawashita, K. Ishikawa and Y. Yoshida

    9th Asian BioCeramics Symposium  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • Fabrication of Osteoconductive Titanium with Ca-ozone Treatment International conference

    M. Sakaguchi, G. Kawachi, M. Maruta, K. Tsuru, S. Matsuya, K. Koyano, K. Ishikawa

    9th Asian BioCeramics Symposium  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • Improvement of the Mechanical Strength of Carbonate Apatite Block International conference

    K. Matsumoto, G. Kawachi, M. Maruta, K. Tsuru, S. Matsuya, I. Takahashi, K. Ishikawa

    9th Asian BioCeramics Symposium  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • Regulation of cells based on surface modification International conference

    Kunio Ishikawa

    2nd AUN/SEED-Net Regional Conference on Materials Engineering  2009.11 

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    Event date: 2009.11

    Country:Thailand  

  • 水晶基板へのアパタイトナノコーティング

    谷内光史、川下将一、石川邦夫、吉田靖弘

    第31回日本バイオマテリアル学会シンポジウム  2009.11 

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    Event date: 2009.11

    Country:Japan  

  • Novel ceramic coating on titanium with high mechanical properties International conference

    Alireza Valanezhad, Kanji Tsuru, Michito Maruta, Giichiro Kawachi, Shigeki Matsuya, Kunio Ishikawa

    22nd International Symposium on Ceramics in Medicine. Bioceramics 22  2009.10 

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    Event date: 2009.10

    Country:Korea, Republic of  

  • The effect of reaction temperature on mechanical property of apatite block derived from dicalcium phosphate and calcium carbonate International conference

    Fumikazu Daitou, Michio Maruta, Kanji Tsuru, Giichiro Kawachi, Shigeki Matsuya, Yoshihiro Terada, Kunio Ishikawa

    22nd International Symposium on Ceramics in Medicine. Bioceramics 22  2009.10 

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    Event date: 2009.10

    Country:Korea, Republic of  

  • オゾン処理を用いた骨伝導性チタン材料の創製

    坂口真実, 川内義一郎, 丸田道人, 都留寛治, 松家茂樹, 古谷野潔, 石川邦夫

    第54回日本歯科理工学会学術講演会  2009.10 

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    Event date: 2009.10

    Country:Japan  

  • 炭酸カルシウム-第二リン酸水素カルシウム混合物の熱処理による炭酸アパタイトブロックの調製

    大東文和, 丸田道人, 川内義一郎, 都留寛治, 松家茂樹, 寺田善博, 石川邦夫

    第54回日本歯科理工学会学術講演会  2009.10 

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    Event date: 2009.10

    Country:Japan  

  • ケイ酸三カルシウム含有αリン酸三カルシウム系アパタイトセメントの創製

    丸田道人, レスタージョセフ カルデナス, 竹内あかり, 都留寛治, 松家茂樹, 石川邦夫

    第53回日本歯科理工学会学術講演会  2009.4 

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    Event date: 2009.4

    Country:Japan  

  • 炭酸カルシウム-第二リン酸カルシウム混合物の水熱処理による炭酸アパタイトブロックの調製 ―第2報―

    大東文和, 竹内あかり, 都留寛治, 松家茂樹, 寺田善博, 石川邦夫

    第53回日本歯科理工学会学術講演会  2009.4 

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    Event date: 2009.4

    Country:Japan  

  • CaCl2水溶液を用いて水熱処理したアルミナ基板のin vitro骨伝導性

    都留寛治, タリク アブドゥラ, 丸田道人, 竹内あかり, 松家茂樹, 寺田善博, 石川邦夫

    第53回日本歯科理工学会学術講演会  2009.4 

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    Event date: 2009.4

    Country:Japan  

  • GRAPE® Technologyを適用したTi-15Zr-4Nb-4Ta合金のin vivo評価―骨と材料の結合強度―

    都留寛治、杉野篤史、早川聡、城崎由紀、石川邦夫、尾坂明義

    日本セラミックス協会 2009 年年会  2009.3 

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    Event date: 2009.3 - 2009.5

    Venue:千葉県野田市   Country:Japan  

  • GM含有α-TCP/ACの顎骨骨髄炎への応用に関する基礎的研究

    二宮嘉昭、武知正晃、太田耕司、平岡美里、南正彦、湯浅哲也、石川邦夫、鎌田伸之

    日本バイオマテリアル学会シンポジウム2008  2008.11 

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    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Effects of ammonium hexafluorosilicate concentration on occluding ability of dentin tubules and composition of the precipitate

    Toshiyuki Suge, Kunio Ishikawa, Takashi Matsuo

    8th World Biomaterials Congress 2008, WBC 2008  2008 

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    Event date: 2008.5 - 2008.6

    Language:English  

    Country:Netherlands  

  • Physical, chemical, and biological evaluation of a newly developed bioactive resin-modified glass ionomer cement

    Ika Dewi Ana, Tetsuya Yuasa, Shigeki Matsuya, Kunio Ishikawa

    8th World Biomaterials Congress 2008, WBC 2008  2008 

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    Event date: 2008.5 - 2008.6

    Language:English  

    Country:Netherlands  

  • Learn from the Bone Carbonate apatite bone replacement

    Kunio Ishikawa

    8th World Biomaterials Congress 2008, WBC 2008  2008 

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    Event date: 2008.5 - 2008.6

    Language:English  

    Country:Netherlands  

  • Effects of ammonium hexafluorosilicate on acid resistance of enamel and dentin

    A. Kawasaki, T. Suge, Kunio Ishikawa, T. Matsuo

    Transactions - 7th World Biomaterials Congress  2004 

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    Event date: 2004.5

    Language:English  

    Country:Australia  

  • Occlusion of dentinal tubules with ammonium hexafluorosilicate for treatment of dentin hypersensitivity

    T. Suge, A. Kawasaki, Kunio Ishikawa, T. Matsuo

    Transactions - 7th World Biomaterials Congress  2004 

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    Event date: 2004.5

    Language:English  

    Country:Australia  

  • Fabrication of carbonate apatite monolith from calcium carbonate with ammonium hydrogen phosphate treatment

    Kunio Ishikawa, S. Matsuya, X. Lin, K. Udoh, Masaharu Nakagawa, Y. Terada

    Transactions - 7th World Biomaterials Congress  2004 

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    Event date: 2004.5

    Language:English  

    Country:Australia  

  • Content and release of bisphenol A from polycarbonate dental product.

    Kazuomi Suzuki, Kunio Ishikawa, Sugiyama, Furuta

    78th General Session and Exhibition of the International Association for Dental Research  2000.4 

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    Event date: 2000.4

    Country:United States  

  • Progress of apatite cement.

    Kunio Ishikawa, Kazuomi Suzuki

    1999.6 

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    Event date: 1999.6

    Country:China  

  • Effect of primer containing calcium phosphate on hybrid layer.

    Kousuke Itou, Y Torii, Kunio Ishikawa, Kazuomi Suzuki, K:

    77th General Session and Exhibition of the International Association for Dental Research  1999.3 

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    Event date: 1999.3

    Country:Canada  

  • An approach to increase the bond strength of plastic bracket to adhesive with sandblasting-silane coupling treatment.

    Guan G, Miyamoto M, Hattori T,Kunio Ishikawa, Kazuomi Suzuki, Takano-Y, Yamamoto

    The 3rd asian-pacific orthodontic conference  1998.11 

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    Event date: 1998.11

    Country:Taiwan, Province of China  

  • Feasibility of alginate membrane as barrier membrane for GTR method.

    Kunio Ishikawa, Yoshiya Ueyama, Mano, Koyama, Kazuomi Suzuki, Tomoya Matsumura

    77th General Session and Exhibition of the International Association for Dental Research  1998.11 

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    Event date: 1998.11

    Country:Taiwan, Province of China  

  • Tissue response to anti-washout apatite cement in the premaxilla of a rat.

    Yoshiya Ueyama, Kunio Ishikawa, Takamitsu Mano, Takahiro Koyama, Hitoshi Nagatsuka, Tomohiro Matsumura, Kazuomi Suzuki

    11th International Symposium on Ceramis in Medicine  1998.11 

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    Event date: 1998.11

    Country:Japan  

  • Blast coating method –Tissue response to titanium implant coated with hydroxyapatite at room temperature-.

    1998.11 

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    Event date: 1998.11

    Country:United States  

  • Comparison of the tissue response to calcium phosphate cements with various setting accelerator.

    Kunio Isihkawa, Youji Miyamoto, Kazuomi Suzuki

    11th International Symposium on Ceramis in Medicine  1998.11 

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    Event date: 1998.11

    Country:United States  

  • Apatite coated titanium implant made with blast coating method.

    Kunio Ishikawa, Kazuomi Suzuki, Yoshiya Ueyama

    The 3rd International Meeting of Pacific Rim Ceramic Societies  1998.9 

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    Event date: 1998.9

    Country:Korea, Republic of  

  • : Setting behaviour of hydroxyapatite putty in serum.

    Kazuomi Suzuki, Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama

    76th General Session and Exhibition of the International Association for Dental Research  1998.6 

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    Event date: 1998.6

    Country:France  

  • Mechanism of inflammatory response to calcium phosphate cement.

    Kunio Ishikawa, Youji Miyamoto, Kazuomi Suzuki, Masaru Nagayama.

    76th General Session and Exhibition of the International Association for Dental Research  1998.6 

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    Event date: 1998.6

    Country:France  

  • In vivo evaluation of plaque control on dentine hypersensitivity.

    Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Kazuomi Suzuki, Takashi Matsuo, Shigeyuki Ebisu

    76th General Session and Exhibition of the International Association for Dental Research  1998.6 

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    Event date: 1998.6

    Country:France  

  • Comparison of dentinal tubules occlusion-CPP, Resin and Potassium oxalate.

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Kazuomi Suzuki, Takashi Matsuo, Shigeyuki Ebisu

    76th General Session and Exhibition of the International Association for Dental Research  1998.6 

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    Event date: 1998.6

    Country:France  

  • Soft tissue response to calcium phosphate cement -Mechanism of inflammatory response-.

    Kunio Ishikawa, Youji Miyamoto, Kazuomi Suzuki

    Third International Congress on Dental Materials  1997.11 

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    Event date: 1997.11

    Country:United States  

  • Mechanism of the inflammatory reaction of conventional calcium phosphate cement.

    Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama, Kazuomi Suzuki

    10th International Symposium on Ceramics in Medicine  1997.10 

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    Event date: 1997.10

    Country:France  

  • Mechanism of the inflammatory reaction of conventional calcium phosphate cement.

    Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama, Kazuomi Suzuki

    10th International Symposium on Ceramics in Medicine  1997.10 

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    Event date: 1997.10

    Country:France  

  • Development of calcium phosphate cement for fast-transformation to apatite.

    Masayuki Kon, Hae-Hyoung Lee, Kunio Ishikawa, Youji Miyamoto, Kenzo Asaoka

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:United States  

  • : Acid resistance of bovine enamel after calcium phosphate precipitation method.

    Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Takashi Matsuo, Shigeyuki Ebisu

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:United States  

  • Basic properties and tissue response of hydroxyapatite putty.

    Kunio Ishikawa, Youji Miyamoto, Takechi M, Masayuki Kon, Kenzo Asaoka, Masaru Nagayama:

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:United States  

  • In vivo evaluation of calcium phosphate precipitation method using dogs.

    Shigeyuki Ebisu, Tetsuya Yasunaga, Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Kenzo Asaoka, Takashi Matsuo

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:Japan  

  • Effects of plaque control on the occlusion of dentin tubules.

    Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Kenzo Asaoka, Takashi Matsuo, Shigeyuki Ebisu

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:United States  

  • Effects of Na2SiO3 on the fluorization of apatite powder.

    Shinya Horiuchi, Kunio Ishikawa, Satoru Tenshin, Kenzo Asaoka, Teruko Takano Ymamoto

    75th General Session and Exhibition of the International Association for Dental  1997.3 

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    Event date: 1997.3

    Country:Japan  

  • Basic properties of calcium phosphate cement containing collagen.

    Youji Miyamoto, Kunio Ishikawa, Takechi M, Masayuki Kon, Kenzo Asaoka, Masaru Nagayama

    Youji Miyamoto, Kunio Ishikawa, Takechi M, Masayuki Kon, Kenzo Asaoka, Masaru Nagayama  1997.3 

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    Event date: 1997.3

    Country:United States  

  • Basic properties of calcium phosphate cement containing collagen.

    Youji Miyamoto, Kunio Ishikawa, Takechi M, Masayuki Kon, Kenzo Asaoka, Masaru Nagayama

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.3

    Country:Japan  

  • Effects of antibiotics addition on the basic properties of nd-FSCPC.

    Takechi M, Youji Miyamoto, Kunio Ishikawa, Kenzo Asaoka, Masaru Nagayama:

    75th General Session and Exhibition of the International Association for Dental Research  1997.3 

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    Event date: 1997.2 - 1997.3

    Country:United States  

  • Effects of antibiotics addition on the basic properties of non-decay type fast-setting calcium phosphate cement:

    Takechi M, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka

    3rd Internet World Congress on Biomedical Sciences  1996.12 

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    Event date: 1996.12

    Country:Japan  

  • Blast coating method -A new coating method of titanium surface with hydroxyapatite at room temperature

    Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama, Kenzo Asaoka

    3rd Internet World Congress on Biomedical Sciences  1996.12 

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    Event date: 1996.12

    Country:Japan  

  • Do calcium phosphate cements really have excellent biocompatibility?

    Youji Miyamoto, Kunio Ishikawa, Takechi M, Tetsuya Yuasa, Tomotake Toh, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    3rd Internet World Congress on Biomedical Sciences  1996.12 

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    Event date: 1996.12

    Country:Japan  

  • Effects of antibitotics addition on the basic properties of non-decay type fast-setting caclium phosphate cement: Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate

    Takechi M, Youji Miyamoto, Kunio Ishikawa, Masayuki Kon, Masaru Nagayama, Kenzo Asaok

    9th International Symposium on Ceramics in Medicine  1996.11 

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    Event date: 1996.11

    Country:Japan  

  • Approaches for bone-replacing calcium phosphate cement International conference

    Kunio Ishikawa, Youji Miyamoto, Takechi M, Taketomo Toh, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    9th International Symposium on Ceramics in Medicine  1996.11 

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    Event date: 1996.11

    Country:Japan  

  • Soft tissue response of calcium phosphate cements:

    Youji Miyamoto, Kunio Ishikawa, Takechi M, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

    9th International Symposium on Ceramics in Medicine  1996.11 

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    Event date: 1996.11

    Country:Japan  

  • Non-decay type fast-setting calcium phosphate cement

    Kunio Ishikawa, Youji Miyamoto, Masayuki Kon, Kenzo Asaoka

    PacRim2  1996.7 

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    Event date: 1996.7

    Country:Australia  

  • Effects of calcium phosphate precipitation method on crystallinity of apatite:

    A. Kawasaki, K. Ishikawa, T. Suge, M. Yoshiyama, K. Asaoka, S. Ebisu

    74th General Session and Exhibition of the International Association for Dental Research  1996.3 

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    Event date: 1996.3

    Country:United States  

  • Behavior of non-decay type fast-setting calcium phosphate cement

    K. Ishikawa, Y. Miyamoto, M. Kon, and K. Asaoka

    74th General Session and Exhibition of the International Association for Dental Research  1996.3 

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    Event date: 1996.3

    Country:United States  

  • Release of antibiotics from calcium phosphate cement

    K. Ishikawa, S. Takagi, L.C. Chow, B.A. Sieck

    74th General Session and Exhibition of the International Association for Dental Research  1996.3 

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    Event date: 1996.3

    Country:United States  

  • Calcium phosphate precipitation method using buffer for post-treatment solution

    T. Suge, K. Ishikawa, A. Kawasaki, M. Yoshiyama, K. Asaoka, S. Ebisu

    1996.3 

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    Event date: 1996.3

    Country:United States  

  • Duration of calcium phosphate precipitation method for dentinal tubules occlusion

    T. Suge, K. Ishikawa, A. Kawasaki, M. Yoshiyama, K. Asaoka, S. Ebisu

    73rd General Session and Exhibition of the International Association for Dental Research  1995.7 

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    Event date: 1995.6 - 2008.7

    Country:Singapore  

  • A basic study on application of non-decay type fast-setting calcium phosphate cement for bone defect -Setting Behavior and Tissue Reaction

    M. Yuasa, Y. Miyamoto, M. Ngayama, K. Ishikawa, M. Kon

    The 6th International Congress on Dental Trauma  1995.5 

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    Event date: 1995.5

    Country:Japan  

  • Formation of nonstoichiometric hydroxyapaite in cements.

    Shozo Takagi, Kunio Ishikawa, Laurence Chow, Norman Sanin, Kenzo Asaoka

    24th Annual Meeting & Exhibition American Association for Dental Research  1995.3 

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    Event date: 1995.3

    Country:United States  

  • Non-decay type fast-setting calcium phosphate cement -Composite of FSCPC with sodium alginate-. International conference

    Youji Miyamoto, Kunio Ishikawa, Miwako Yuasa, Masayuki Kon, Kenzo Asaoka

    10th Symposium on Apatite (Kochi Japan: December 15-16, 1994): Transactions of the 10th Symposium on Apatite 60-61.  1994.12 

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    Event date: 1994.12

    Country:Japan  

  • Blast coating of apatite on titanium surface -SEM observation and XRD analysis-. International conference

    Kunio Ishikawa, Youji Miyamoto, Miwako Yuasa, Masayuki Kon, Kenzo Asaoka

    10th Symposium on Apatite (Kochi Japan: December 15-16, 1994): Transactions of the 10th Symposium on Apatite 62-63.  1994.12 

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    Event date: 1994.12

    Country:Japan  

  • In viro reactions of functionally gradient calcium phosphate

    Hirokazu Fukao, Yohji Miyamoto, Masahiro Sawada, Masaru Nagayama, Masayuki Kon, Kunio Ishikawa, Kenzo Asaoka:

    The 3rd World Congress for Oral Implantology  1994.4 

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    Event date: 1994.4

    Country:Japan  

  • Formation of hydroxyapatite in new calcium phosphate cements.

    Shozo Takagi, Laurence C. Chow, Kunio Ishikawa

    72th General Session and Exhibition of the International Association for Dental Research  1994.3 

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    Event date: 1994.3

    Country:United States  

  • Release of antibiotics from calcium phosphte cement

    Kunio Ishiakwa, Kenzo Asaoka

    The 9th annual meeting of apatite symposium  1993.12 

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    Event date: 1993.12

    Country:Japan  

  • Effect of supersaturation on apatite crystal growth.

    Kunio Ishikawa, Edward D. Eanes, Ming S. Tung

    71th General Session and Exhibition of the International Association for Dental Research  1993.3 

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    Event date: 1993.3

    Country:Japan  

  • The morphology of hydroxyapatite. Gordon conference on calcium phosphate

    Kunio Ishikawa, Edward D. Eanes:

    Gordon conference on calcium phosphate  1992.3 

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    Event date: 1992.3

    Country:Japan  

  • The hydrolysis of anhydrous dicalcium phosphate to hydroxyapatite

    Norman Sanin, Kunio Ishikawa, Shozo Takagi, Laurence Chow, Edward D. Eanes

    21th Annual Meeting & Exhibition American Association for Dental Research  1992.3 

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    Event date: 1992.3

    Country:Japan  

  • The hydrolysis of anhydrous dicalcium phosphate to hydroxyapatite 

    1992.3 

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    Event date: 1992.3

    Country:Japan  

  • In vitro dissolution and precipitation of calcium phosphate phases on various biomaterials correlates with in vivo bioactivity

    Paul Ducheyne, Shula R. Radin, Lind King, Kunio Ishikawa, C. S. Kim

    4th International Symposium on Ceramics in Medicine (April 10, 1990):  1990.10 

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    Event date: 1990.10

    Country:Other  

  • 炭酸カルシウム球状粒子の作製.

    石川 邦夫

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    Country:Japan  

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MISC

  • Antibacterial and osteogenic thin films on Ti-6Al-4V surface formed by passivation process in copper hydroxide solution

    Masaya Shimabukuro, Miki Morinobu, Akira Tsuchiya, Ryo Kishida, Masakazu Kawashita, Kunio Ishikawa

    Science and Technology of Advanced Materials   2024.2

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    Language:Others  

    DOI: 10.1080/14686996.2024.2303327

  • Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft

    Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Advanced Healthcare Materials   2024.1

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    Language:Others  

    DOI: 10.1002/adhm.202303245

  • Osseointegration enhancement by controlling dispersion state of carbonate apatite in polylactic acid implant

    Cheng Zhang, Koichiro Hayashi, Kunio Ishikawa

    Colloids and Surfaces B: Biointerfaces   2023.12

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    DOI: 10.1016/j.colsurfb.2023.113588

  • Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels

    Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Materials   2023.12

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    DOI: 10.3390/ma16247518

  • Ant‐nest type porous scaffold with micro‐struts consisting of carbonate apatite for promoting bone formation and scaffold resorption

    2023.9

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    Abstract

    Scaffolds having appropriate mechanical strength and providing a proper microenvironment for osteogenesis are expected to be effective alternatives to autografts for bone regeneration. In this study, ant‐nest type porous (ANP) scaffolds consisting of CO3Ap were fabricated using calcium carbonate powder or slurry and two types of polyurethane foam through a dissolution–precipitation reaction. ANP‐type, three‐dimensional, interconnected porous CO3Ap scaffolds were fabricated by burning out the struts of polyurethane foams embedded in CaCO3, followed by compositional transformation from CaCO3 to CO3Ap. The types of polyurethane foam and impregnation methods of CaCO3 into polyurethane form affected the geometry of the resulting ANP structures. Mechanical and in vivo biological performances of these scaffolds relied on the geometry of the ANP structures. The ANP structures displayed had a clear structural advantage in bone regeneration, owing to the promotion of cell and tissue migration throughout the scaffolds. In particular, ANP‐structured scaffolds, which had highest porosity, interconnectivity, and smallest strut thickness, had a mechanical strength comparable to cancellous bone, formed more new bone, were highly resorbed, resulting in cancellous bone‐like bone tissue regeneration at 12 weeks of healing. The results suggest that bone regeneration after the migration of cell and tissue into the entire scaffolds is affected by strut thickness preferentially over porosity and interconnectivity. ANP‐structured CO3Ap scaffolds are attractive for bone regeneration.

    DOI: 10.1002/jbm.a.37608

  • Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

    Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    ACS Applied Materials &amp; Interfaces   2023.7

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    DOI: 10.1021/acsami.3c06263

  • Fabrication of low-crystalline Mg-substituted β-tricalcium phosphate foam via dissolution–precipitation reaction

    2023.7

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    DOI: 10.1007/s12034-023-02981-9

  • Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study

    2023.1

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    Apatite cement (AC), which has excellent osteoconductive ability, and alpha-tricalcium phosphate (α-TCP), which can be used for bone replacement, are useful bone substitute materials. The objective of this study was to clarify the physical properties and antimicrobial release ability of antibiotic-loaded AC/α-TCP composites in vitro. Gentamicin-loaded, rapid setting AC/α-TCP composites were prepared in 2 mixing ratios (10:3 and 10:6). The cement paste of AC/α-TCP composites was prepared in a plastic mold and dried in a thermostatic chamber at 37 °C and 100&#37; relative humidity for 24 h. A diametral tensile strength test, powder X-ray diffraction analysis, and gentamicin release test were performed. The diametral tensile strengths of the AC/α-TCP composites were significantly less than that of AC alone. Powder X-ray diffraction patterns exhibited the characteristic peaks of hydroxyapatite in the AC/α-TCP composites and gentamicin-loaded AC/α-TCP composites. The concentration of the released gentamicin was maintained above the minimum inhibitory concentration of Staphylococcus aureus until Day 30 in both the gentamicin-loaded AC/α-TCP composites (10:3 and 10:6). Our results suggest that a gentamicin-loaded AC/α-TCP composite has potential as a drug delivery system. Further study is essential to investigate the antimicrobial activity and safety of the gentamicin-loaded AC/α-TCP composites in animal models.

    DOI: 10.3390/ma16030995

  • Endowing Osseointegration Ability to Bioinert Alumina by Carbonate Apatite Coating

    Koichiro Hayashi, Kunio Ishikawa

    Surfaces and Interfaces   2022.12

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    DOI: 10.1016/j.surfin.2022.102617

  • Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure

    Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Koichiro Hayashi, Kunio Ishikawa, Youji Miyamoto

    Journal of Materials Science: Materials in Medicine   2022.12

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    DOI: 10.1007/s10856-022-06710-2

  • Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation

    Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Journal of Advanced Research   2022.11

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    Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation

    DOI: 10.1016/j.jare.2021.12.010

  • 炭酸アパタイトハニカム人工骨に搭載されたチャネルと微細孔が分節型骨欠損の再建に与える影響と相互作用について

    柴原 啓吾, 林 幸壱朗, 石川 邦夫, 中島 康晴

    日本整形外科学会雑誌   2022.9

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  • Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System

    Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Kunio Ishikawa

    ACS Nano   2022.7

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    DOI: 10.1021/acsnano.2c03776

  • Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks

    Maab Elsheikh, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa

    Regenerative Biomaterials   2022.4

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    DOI: 10.1093/rb/rbac010

  • Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects

    Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima, Kunio Ishikawa

    Frontiers in Bioengineering and Biotechnology   2022.3

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    DOI: 10.3389/fbioe.2022.825831

  • Surface functionalization with copper endows carbonate apatite honeycomb scaffold with antibacterial, proangiogenic, and pro-osteogenic activities Reviewed

    Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    Biomaterials Advances   2022.3

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    Surface functionalization with copper endows carbonate apatite honeycomb scaffold with antibacterial, proangiogenic, and pro-osteogenic activities

    DOI: 10.1016/j.bioadv.2022.212751

  • Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis Reviewed

    Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa

    Materials Today Bio   2022.3

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    DOI: 10.1016/j.mtbio.2022.100247

  • Fabrication and histological evaluation of porous carbonate apatite blocks using disodium hydrogen phosphate crystals as a porogen and phosphatization accelerator Reviewed

    Pery Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa

    Journal of Biomedical Materials Research Part A   2022.2

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    Fabrication and histological evaluation of porous carbonate apatite blocks using disodium hydrogen phosphate crystals as a porogen and phosphatization accelerator

    DOI: 10.1002/jbm.a.37374

  • Multiscale Porous Scaffolds Constructed of Carbonate Apatite Honeycomb Granules for Bone Regeneration

    Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa

    Materials & Design   2022.2

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    DOI: 10.1016/j.matdes.2022.110468

  • Feasibility study on surface morphology regulation of β-tricalcium phosphate bone graft for enhancing cellular response

    2022.2

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    DOI: 10.1016/j.ceramint.2022.02.200

  • Fabrication of vaterite blocks from a calcium hydroxide compact Reviewed

    Kunio Ishikawa, Pery Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya

    Ceramics International   2022.2

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    Fabrication of vaterite blocks from a calcium hydroxide compact

    DOI: 10.1016/j.ceramint.2021.10.206

  • No-Observed-Effect Level of Silver Phosphate in Carbonate Apatite Artificial Bone on Initial Bone Regeneration Reviewed

    Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

    ACS Infectious Diseases   2022.1

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    DOI: 10.1021/acsinfecdis.1c00480

  • Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V

    Sunarso, Akira Tsuchiya, Riki Toita, Kanji Tsuru, Kunio Ishikawa

    Materials Letters   2021.12

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    DOI: 10.1016/j.matlet.2021.130716

  • Enhancement of bone to polylactic acid plate bonding by carbonate apatite coating

    Cheng Zhang, Koichiro Hayashi, Kunio Ishikawa

    Ceramics International   2021.10

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    DOI: 10.1016/j.ceramint.2021.06.252

  • Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading

    Yoichiro Ogino, Yasunori Ayukawa, Noriko Tachikawa, Masahiro Shimogishi, Youji Miyamoto, Keiko Kudoh, Naoyuki Fukuda, Kunio Ishikawa, Kiyoshi Koyano

    Materials   2021.10

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    DOI: 10.3390/ma14195760

  • Honeycomb Scaffold-Guided Bone Reconstruction of Critical-Sized Defects in Rabbit Ulnar Shafts

    Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima, Kunio Ishikawa

    ACS Applied Bio Materials   2021.9

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    DOI: 10.1021/acsabm.1c00533

  • 炭酸アパタイトハニカムブロックを用いた分節型骨欠損の骨再建

    柴原 啓吾, 林 幸壱朗, 佐藤 太志, 中島 康晴, 石川 邦夫

    日本整形外科学会雑誌   2021.8

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  • 人工骨は自家骨を超えることができるか 人工骨としての炭酸アパタイトの基礎と臨床応用

    石川 邦夫

    日本整形外科学会雑誌   2021.3

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  • Fabrication and evaluation of interconnected porous carbonate apatite from alpha tricalcium phosphate spheres Reviewed

    Kunio Ishikawa, Tya Indah Arifta, Koichiro Hayashi, Kanji Tsuru

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   2021.2

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    DOI: 10.1002/jbm.b.34117

  • Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes.

    2020.2

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  • Sol-gel synthesis of calcium phosphate-based biomaterials - A review.

    @Kunio Ishikawa, Aivaras Kareiva

    CHEMIJA   2020.2

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  • 顎骨再建材料ルネサンス~骨組成骨補塡材を中心に~

    @石川 邦夫

    DE/211号(日本歯科理工学会誌/Vol.39 No.1) 特集/顎骨再建材料   2020.1

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  • Carbonate apatite bone replacement: Learn from the bone.

    @Kunio Ishikawa

    Journal of the Ceramic Society of Japan   2019.9

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    DOI: doi:10.2109/jcersj2.19042

  • 骨と炭酸アパタイト人工骨と硫酸カルシウム

    @石川 邦夫

    硫酸と工業Sulphuric acid and industry   2019.3

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  • 驚異の人工骨補填材:炭酸アパタイト

    @石川 邦夫

    (人工臓器-最新の進歩)人工臓器   2018.12

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  • Nanoporous biomaterials for uremic toxin adsorption in artificial kidney systems: A review.

    @Wee-Keat Cheah, @Kunio Ishikawa, @Radzali Othman, @Fei-Yee Yeoh

    Journal of Biomedical Materials Research Part B: Applied Biomaterials   2016.2

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  • 細胞3次元組織化のための材料:セラミックス

    石川 邦夫

    遺伝子医学MOOK 別冊「細胞の3次元組織化に不可欠な最先端材料技術-再生医療,その支援分野(細胞研究,創薬研究)への応用と発展のために」   2014.2

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  • Organic-Inorganic composites designed for biomedical application.

    Toshiki Miyazaki, Ishikawa Kunio, Yuki Shirosaki, Chikara Ohtsuki

    2013.11

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  • 用語解説:セラミックス

    石川 邦夫

    再生医療   2013.8

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  • 人工骨置換材としての炭酸アパタイト

    石川 邦夫

    2012.11

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  • Macroporous bioceramics: A remarkable material for bone regeneration.

    Kien-Seng Lew,, Radzali Othman, Ishikawa Kunio, Fei-Yee Yeoh

    Journal of Biomaterials Applications,   2012.9

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  • Macroporous bioceramics: a remarkable material for bone regeneration.

    Kien-Seng Lew, Radzali Othman, Ishikawa Kunio, Fei-Yee Yeoh

    2011.8

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  • Bone substitute fabrication based on dissolution-precipitation reaction.

    Ishikawa Kunio

    Materials   2010.2

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  • 骨リモデリングに完全調和するバイオセラミックス

    石川邦夫

    バイオマテリアル27(4), 2009.   2009.4

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  • アパタイトと生命体

    石川邦夫

    アパタイトフォーラム2   2009.4

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  • バイオマテリアル研究の醍醐味

    石川邦夫

    バイオマテリアル27(1), 2009.   2008.12

  • 21世紀における,歯科材料の生物学的安全性について―とくに内分泌攪乱作用に関連して―

    今井庸二,平林茂,西山典宏,根本君也,武田昭二,本郷敏雄,石川邦夫,河合達志

    歯科材料・器械21巻4号220-260頁,2002年.   2008.12

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  • 骨補填材の現在:アパタイトの嘘と本当―基礎編2―

    石川邦夫

    インプラントジャーナル13,53-67、2003.   2008.12

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  • ブラストコーティングによるチタンのアパタイトコーティングとその生体組織反応

    石川邦夫

    2008.4

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  • 歯科材料におけるセラミックスへの期待と展望、マテリアルインテグレーション

    石川邦夫

    歯科材料におけるセラミックスへの期待と展望、マテリアルインテグレーション   2007.4

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  • 生体に学ぶ・骨組織と置換する機能系材料.マテリアル

    石川邦夫

    2007.4

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  • インプラント治療が変わる!!.The Journal of Dental Engineering

    石川邦夫

    2006.4

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  • 歯科におけるナノテクノロジーの活用の現状と将来

    石川邦夫

    日本歯科評論66(3), 117-122, 2006.   2006.4

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  • 高強度セラミックスの材料学的特性とその評価

    松家茂樹,石川邦夫

    2006.4

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  • 特集「セラミックスと細胞のナノインターフェイス制御」アパタイトセラミックスと細胞とのインターフェイスにおける相互作用

    石川邦夫

    バイオマテリアル23(5), 348-352, 2005.   2005.4

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  • 骨補填材の現在-その4-:アパタイトの嘘と本当―応用編2―

    石川 邦夫

    インプラントジャーナル15, 31-50, 2003.   2003.4

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  • 生体組織工学と生体材料「骨再生を中心として」

    石川邦夫

    2003.4

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  • 化学ベクトルセラミックス―骨形成をコントロールする亜鉛徐放セラミックス―

    伊藤敦夫、河村春生、池内正子、大串始、十河友、大塚誠、石川邦夫、神崎紀子、小沼一雄、 一ノ瀬昇

    2003.4

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  • 骨補填材の現在-その3-:アパタイトの嘘と本当―応用編1―

    石川 邦夫

    インプラントジャーナル14, 49-65, 2003.   2003.4

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  • Present situation and problems of dental materials

    Kunio Ishikawa

    Corrosion Engineering 51, 449-469, 2002   2002.4

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  • 歯科材料の現状と問題点

    石川邦夫

    材料と環境,51(8), 331-340, 2002   2002.4

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  • 骨補填材の現在:アパタイトの嘘と本当―基礎編―.

    石川邦夫

    インプラントジャーナル12,35-50、2002.   2002.4

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  • 亜鉛含有TCP.

    伊藤敦夫、池内正子、河村春生、大塚誠、石川邦夫、一ノ瀬昇

    The Bone,439-442,15(5), 2001.   2001.4

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  • アパタイト系骨修復材料

    石川邦夫

    2000.5

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  • 骨とアパタイトとアパタイトセメント.

    石川邦夫

    2000.4

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  • 硬組織再建、再生に向けた生体材料研究.

    石川 邦夫

    生体材料 :,18(3), 152-161, 2000.   2000.4

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Industrial property rights

Patent   Number of applications: 35   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本口腔インプラント学会

  • 日本アパタイト研究会

  • 日本セラミックス協会

  • International Association for Dental Research

  • 日本バイオマテリアル学会

  • 日本小児歯科学会

  • 日本歯科保存学会

  • 日本歯科理工学会

  • International Society for Ceramics Medicine

  • Society for Biomaterials

  • 日本再生医療学会

  • Orthopedics Biomaterial Bureau

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Committee Memberships

  • Chairman   Domestic

    2024.4 - 2026.3   

  • Executive   Domestic

    2020.4 - 2022.3   

  • 日本歯科理工学会   九州支部長   Domestic

    2020.4 - 2022.3   

  • International Society for Ceramics in Medicine   Chairman   Foreign country

    2019.4 - 2025.3   

  • Chairman   Domestic

    2013.4 - 2015.3   

  • 日本セラミックス協会 生体関連材料部会   部会長   Domestic

    2013.4 - 2015.3   

  • Councilor   Foreign country

    2009.1 - 2010.12   

  • Executive   Domestic

    2002.4 - Present   

  • 日本歯科理工学会   常任理事   Domestic

    2002.4 - Present   

  • Executive   Domestic

    2000.4 - Present   

  • Organizer   Domestic

    1998.4 - Present   

  • 日本セラミックス協会   生体関連部会幹事   Domestic

    1998.4 - Present   

  • Councilor   Domestic

    1997.5 - Present   

  • Councilor   Domestic

    1997.4 - Present   

▼display all

Academic Activities

  • 科学研究費補助金審査委員

    Role(s): Review, evaluation

    日本学術振興会  2021.4 - 2022.3

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    Type:Scientific advice/Review 

  • 座長(Chairmanship) International contribution

    ( 名古屋 ) 2018.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2018.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    整形外科バイオマテリアル研究会  ( 岡山 ) 2017.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 岡山 ) 2017.11 - 2017.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2017.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第70回日本歯科理工学会  ( 新潟 ) 2017.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( Timişoara ) 2017.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.8

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.5 - 2016.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2016.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2015.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2015.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2015.8 - 2015.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2015.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第34回整形外科バイオマテリアル研究会  ( 大阪市 ) 2014.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第36回日本バイオマテリアル学会大会  ( 東京都 ) 2014.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2014.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本セラミックス協会第27回秋季シンポジウム  ( 鹿児島大学 ) 2014.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2014.8

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本セラミックス協会2014年年会  2014.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2013.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2013.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本セラミックス協会第26回秋季シンポジウム  ( 長野 ) 2013.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2013.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2013.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2013.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本セラミックス協会2013年年会  ( 東京 ) 2013.3

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2012.12 - 2013.11

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    Type:Scientific advice/Review 

  • 大会長 International contribution

    2012.10

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    Type:Competition, symposium, etc. 

    Number of participants:250

  • 大会長

    第60回日本歯科理工学会学術講演会(創立30周年記念大会)  ( 九州大学医学部 百年講堂 ) 2012.10

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • 座長(Chairmanship)

    日本セラミックス協会第25回秋期シンポジウム  ( 名古屋 ) 2012.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    5th International Conference on Biomaterials Tissu Engineering & Medical Devices” BiomMedD’2012,  2012.8 - 2012.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2012.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2011.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( つくば市 ) 2011.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本バイオマテリアル学会  ( 京都 ) 2011.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2011.10

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    Type:Competition, symposium, etc. 

  • 大会長

    第23年度日本歯科理工会九州支部夏期セミナー  ( 唐津シーサイドホテル ) 2011.8

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    Type:Competition, symposium, etc. 

    Number of participants:70

  • 座長(Chairmanship) International contribution

    2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2010.12

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    Type:Competition, symposium, etc. 

  • 世話人

    第14回生体関連セラミックス討論会  ( 京都テルサ ) 2010.12

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    Type:Competition, symposium, etc. 

    Number of participants:90

  • 座長(Chairmanship)

    第14回生体関連セラミックス討論会  ( 京都テルサ ) 2010.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 大阪国際会議場 ) 2010.11

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    Type:Competition, symposium, etc. 

  • 大会長

    第22年度日本歯科理工会九州支部夏期セミナー  ( 別府 亀の井ホテル ) 2010.8

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    Type:Competition, symposium, etc. 

    Number of participants:70

  • 特別研究員等審査会および国際事業委員会対象事業審査員

    Role(s): Review, evaluation

    2010.8 - 2012.7

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    Type:Scientific advice/Review 

  • 座長(Chairmanship) International contribution

    2010.6

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    Type:Competition, symposium, etc. 

  • Executive Chair International contribution

    Asian BioCeramics 2009  ( Nagoya Japan ) 2009.12

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    Type:Competition, symposium, etc. 

    Number of participants:120

  • 大会長

    第18回アパタイト研究会  ( 九州大学病院キャンパス ) 2009.11

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    Type:Competition, symposium, etc. 

    Number of participants:70

  • 座長(Chairmanship)

    日本セラミックス協会 2009 年年会  ( 東京理科大 千葉県野田市 ) 2009.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2009.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2009.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    ( 名古屋国際会議場 ) 2008.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第12回生体関連セラミックス討論会  ( 横浜市 ) 2008.12

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    Type:Competition, symposium, etc. 

  • Executive Chair International contribution

    Asian BioCeramics 2008  ( Chennai India ) 2008.11

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    Type:Competition, symposium, etc. 

    Number of participants:120

  • 座長(Chairmanship) International contribution

    2008.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    2008.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 上海 ) 2007.11 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本セラミックス協会第19回秋季シンポジウム  ( 山梨県甲府市 ) 2006.9 - Present

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    文部科学省  2006.4 - 2008.3

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    Type:Scientific advice/Review 

  • 座長(Chairmanship) International contribution

    ( 京都 ) 2005.12 - Present

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    Type:Competition, symposium, etc. 

  • 大会長 International contribution

    ( 福岡 ) 2003.10 - Present

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    Type:Competition, symposium, etc. 

    Number of participants:120

  • 科学技術動向研究センター専門調査員

    Role(s): Review, evaluation

    文部科学省  2001.4 - 2008.3

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    Type:Scientific advice/Review 

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Research Projects

  • 骨組成骨セメントの創製

    2024.5 - 2029.3

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    Authorship:Principal investigator 

  • 炭酸アパタイト(骨組成骨補填材)の軟組織結合への展開

    2024.5 - 2025.3

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    Authorship:Principal investigator 

  • 骨組成連通多孔性人工骨に関する研究開発

    2024 - 2025

    国立研究開発法人日本医療研究開発機構

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    Authorship:Principal investigator  Grant type:Contract research

  • 炭酸アパタイト(骨組成骨補填材)の軟組織結合への展開

    2024

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    Authorship:Principal investigator  Grant type:Contract research

  • 炭酸アパタイト(骨組成骨補填材)の軟組織結合への展開

    2024

    橋渡し研究戦略的推進プログラム 令和6年シーズA研究費

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 骨組成スポンジ状人工骨の創製

    2023 - 2024

    橋渡し研究プログラム シーズA

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    Authorship:Principal investigator  Grant type:Contract research

  • 骨組成スポンジ状人口骨の創製

    2023

    橋渡し研究戦略的推進プログラム 令和5年シーズA研究費

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 炭酸アパタイトハニカムブロック骨置換材に関する研究

    2022.10 - 2026.2

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 医療機器等研究成果展開事業「骨組成連通多孔性人工骨に関する研究開発」

    2022.5 - 2025.3

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    Authorship:Principal investigator 

  • 骨組成連通多孔性人工骨に関する研究開発

    2022 - 2024

    国立研究開発法人日本医療研究開発機構

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    Authorship:Principal investigator  Grant type:Contract research

  • 顆粒結合型炭酸アパタイト人工骨の創製

    Grant number:21K19914  2021 - 2022

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 骨組成セメントの創製

    2021

    橋渡し研究戦略的推進プログラム 令和3年シーズA研究費

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 顆粒結合型炭酸アパタイト人工骨の創製

    2020.4 - 2024.3

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    Authorship:Principal investigator 

  • 橋渡し研究戦略的推進プログラム/自家骨採取は不要:炭酸アパタイト人工骨による骨再生

    2020.4 - 2022.3

    国立研究開発法人 日本医療研究開発機構 

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    Authorship:Coinvestigator(s) 

  • 炭酸アパタイト骨補填材の気孔形状・サイズが骨伝導性および骨置換性に及ぼす影響

    2019.4 - 2023.3

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    Authorship:Principal investigator 

    超高齢社会の到来に伴い病気や外傷などで発生した骨の欠損部の治療が急増しています。現在の治療は自分の骨を取って、欠損部に補填する方法が主流ですが、自分の健全な部位から骨をとる必要があります。
     骨の組成は炭酸アパタイトという無機物質ですが、申請者は骨と同じ組成の炭酸アパタイト骨補填材の調製法を考案し、薬事承認を得て実用化しました。
     本研究では炭酸アパタイト骨補填材の更なる高機能化を目指し、多孔体化などの構造が炭酸アパタイト骨補填材への骨のでき方や骨との置き換わりを研究します。

  • 炭酸アパタイトハニカムブロック骨置換材に関する研究

    2019.3 - 2023.2

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 炭酸アパタイト骨補填材の気孔形状・サイズが骨伝導性および骨置換性に及ぼす影響

    Grant number:19H04469  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ポリエチレンテレフタレートに骨伝導性を付与する挑戦

    2018.6 - 2023.3

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    Authorship:Principal investigator 

  • 炭酸アパタイトハニカムブロック骨置換材に関する研究

    2018.2 - 2020.2

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • ポリエチレンテレフタレートに骨伝導性を付与する挑戦

    Grant number:18K19928  2018 - 2021

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 連通多孔性炭酸アパタイト人工骨置換材

    2018

    橋渡し研究加速ネットワークプログラム

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    Authorship:Principal investigator  Grant type:Contract research

  • 産学連携医療イノベーション創出プログラム(ACT-MS)「組織再生自己硬化型細胞遮断膜の創製」

    2017.10 - 2018.3

    国立研究開発法人 日本医療研究開発機構 

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    Authorship:Principal investigator 

  • 炭酸アパタイト被覆チタンインプラントの創製

    2017 - 2018

    日本学術振興会  二国間交流

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    Authorship:Principal investigator  Grant type:Joint research

  • 組織再生自己硬化型細胞遮断膜の創製

    2017 - 2018

    医療分野研究成果展開事業 産学連携医療イノベーション創出プログラム(ACT-MS)

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    Authorship:Principal investigator  Grant type:Contract research

  • 連通多孔性炭酸アパタイト人工骨置換材

    2017

    橋渡し研究加速ネットワークプログラム

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 自己硬化型β型リン酸三カルシウム骨補填材の創製とその病理組織学的検索

    Grant number:16721541  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 硫酸カルシウムから作製した多孔質炭酸アパタイトと骨髄幹細胞による骨再生医療の開発

    Grant number:16720159  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 高強度型炭酸アパタイトブロック人工骨置換材

    2016

    橋渡し研究加速ネットワークプログラム

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 医療用セメントに関する研究

    2015.4 - 2019.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 医療用セメントに関する研究

    2015.4 - 2018.3

    太平洋セメント株式会社 

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    Authorship:Principal investigator 

    生体親和性の高いカルシウム-シリカ系材料を含む医療用セメントの機能性向上を図り、新たな高機能性医療用セメントを研究・評価する。

  • 高骨伝導性を示す低結晶性リン酸カルシウムの創製とその骨伝導性評価

    2015 - 2017

    日本学術振興会  二国間交流

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    Authorship:Principal investigator  Grant type:Joint research

  • PLGA階層化炭酸アパタイトフォームの界面制御

    Grant number:25107725  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 骨伝導性に優れる骨補填材

    2013

    橋渡し研究加速ネットワークプログラム研究開発

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 戦略的イノベーション創出推進プログラム「革新的硬組織再生・再建システム創製」

    2012.11 - 2022.3

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    Authorship:Principal investigator 

    骨や歯などの硬組織欠損の再生再建を総合的に治療する革新的硬組織再生・再建システムを創製します。骨や歯の機能を代替するインプラント材に関しては、インプラント材が早く、強く骨と結合するようにCa表面修飾インプラント材を開発する。また、骨欠損が大きい場合には骨の再生を行う必要があるが、骨リモデリングプロセスを活性化させ、迅速に骨に置換される炭酸アパタイト骨置換材を開発する。

  • 研究成果展開事業 研究成果最適展開プログラム フィジビリティスタディステージ シーズ顕在化タイプ「蟻の巣型炭酸アパタイト連通多孔体の創製」

    2012.4 - 2013.3

    独立行政法人科学技術振興機構 

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    Authorship:Principal investigator 

    蟻の巣型炭酸アパタイト連通多孔体を調製することを目的とする。炭酸アパタイトは生理的環境下では熱力学的に最安定相であり、チャンバー試験や顆粒状炭酸アパタイトの病理組織学的検索結果からも炭酸アパタイトは生理環境下では吸収されない。一方、破骨細胞が形成するハウシップ窩環境では吸収される。したがって、炭酸アパタイトを基盤材料として用いる場合、破骨細胞や骨芽細胞が内部に侵入できる連通多孔体とすることによって人工骨置換材の骨置換速度を向上させることができる。一方、臨床応用の際はある程度の機械的強さが必要であり、ブロックとして臨床応用する際にはチッピングを起こさないことも必須要件である。
     炭酸アパタイト骨置換材の骨置換速度の促進と炭酸アパタイトの臨床における操作性の観点から、多孔性を制御する必要があると判断

  • 薬剤徐放型炭酸アパタイト

    2012 - 2015

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • リン酸三カルシウムフォームセメント

    Grant number:24659861  2012 - 2013

    科学研究費助成事