記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives: This study evaluated the correlation among the diffusion-derived parameters obtained by monoexponential (ME), intravoxel incoherent motion (IVIM) and γ distribution (GD) models and compared these parameters among representative orofacial tumours.

Methods: Ninety-two patients who underwent 1.5 T MRI including diffusion-weighted imaging were included. The shape parameter (κ), scale parameter (θ), ratio of the intracellular diffusion (ƒ1), extracellular diffusion (ƒ2) and perfusion (ƒ3) were obtained by the GD model; the true diffusion coefficient (D) and perfusion fraction (f) were obtained by the IVIM model; and the apparent diffusion coefficient (ADC) was obtained by the ME model.

Results: ƒ1 had a strongly negative correlation with the ADC (ρ = -0.993) and D (ρ = -0.926). A strong positive correlation between f and ƒ3 (ρ = 0.709) was found. Malignant lymphoma (ML) had the highest ƒ1, followed by squamous cell carcinoma (SCC), malignant salivary gland tumours, pleomorphic adenoma (Pleo) and angioma. Both the IVIM and GD models suggested the highest perfusion in angioma and the lowest perfusion in ML. The GD model demonstrated a high extracellular component in Pleo and revealed that the T4a+T4b SCC group had a lower ƒ2 than the T2+T3 SCC group, and poor to moderately differentiated SCC had a higher ƒ1 than highly differentiated SCC.

Conclusions: Given the correlation among the diffusion-derived parameters, the GD model might be a good alternative to the IVIM model. Furthermore, the GD model's parameters were useful for characterizing the pathological structure.

DOI： 10.1259/dmfr.20200252.

リポジトリ公開URL： https://hdl.handle.net/2324/7218267

記述言語：英語   掲載種別：研究論文（学術雑誌）  

AIM: To compare the goodness of fit and correlations between diffusion kurtosis imaging (DKI) and a mono-exponential (ME) model, to compare the corrected apparent diffusion coefficient (Dapp) and apparent kurtosis (Kapp) of the DKI model, and the apparent diffusion coefficient (ADC) of the ME model among the various orofacial lesions, and to evaluate the diagnostic performances between the two models. MATERIALS AND METHODS: A total of 100 orofacial lesions underwent echo-planar diffusion magnetic resonance imaging (MRI) with four b-values. The goodness of fit was evaluated using Akaike information criterion. The correlations of the diffusion-derived parameters were evaluated. The diagnostic performance was analysed by receiver operating characteristics (ROC). RESULTS: The DKI model showed a significantly better goodness of fit than the ME model (p<0.0001). The Kapp had a strongly negative correlation with the Dapp (ρ=–0.749) and ADC (ρ=–0.938). A strongly positive correlation existed between the Dapp and ADC (ρ=0.906). All parameters differed significantly between benign tumours and malignant tumours (p<0.05). In differentiating benign tumours from the malignant tumours, the AUC of Dapp (0.871) was larger than that of ADC (0.805); however, a significant difference was not found (p=0.102). CONCLUSION: The DKI model had better goodness of fit than the ME model. Furthermore, the Dapp and Kapp were also characteristic for each pathological category; however, the DKI model did not yield a significantly higher diagnostic performance than the ME model, which might be related to the high correlation among the diffusion-derived parameters and wide variation among categories.

DOI： 10.1016/j.crad.2020.01.008.

リポジトリ公開URL： https://hdl.handle.net/2324/7218275

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Rationale and Objectives

We aimed to compare the distortion ratio (DR), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) between turbo spin-echo (TSE)-diffusion-weighted imaging (DWI) and echo-planar imaging (EPI)-DWI of the orofacial region and prove the usefulness of TSE-DWI for the differential diagnosis of orofacial lesions.
Materials and methods

The DR, SNR, and CNR of both sequences were compared in 42 cases. Then, the apparent diffusion coefficient (ADC) of various orofacial lesions obtained by TSE-DWI was investigated in 143 lesions.
Results

In the first study, 38 of 42 cases were analyzed. TSE-DWI showed a significantly lower DR (p < 0.05) and higher SNR and CNR than EPI-DWI (p < 0.05), indicating the superiority of TSE-DWI. In the second study, 114 cases (79.3%) were successfully analyzed. When lesions were divided into cysts, benign tumors, squamous cell carcinoma, malignant lymphoma, and other malignant tumors (OT), significant differences were observed in all pairs of lesions (p < 0.05) except squamous cell carcinoma and OT (p = 0.877). The area under the curve for distinguishing benign from malignant tumors was 0.80 with a cutoff ADC of 1.29 × 10-3 mm²/s.
Conclusion

TSE-DWI produced better quality images than EPI-DWI. TSE-DWI yields the high possibility of obtaining ADC in the orofacial region, and this value was considered useful for the differential diagnosis of orofacial lesions.

DOI： https://doi.org/10.1016/j.acra.2018.11.016

リポジトリ公開URL： https://hdl.handle.net/2324/7218274

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE:
Our first objective was to prove the validity of the six-point Dixon method for estimating the proton density fat fraction (PDFF) of the salivary gland. The second objective was to estimate the salivary gland PDFF using Dixon method to evaluate the pathological conditions.
METHODS:
At first, 12 volunteers underwent two types of sequences: single-voxel magnetic resonance spectroscopy and the Dixon method and the PDFFs obtained by the two methods were compared. Next, a total of 67 individuals [normal, n = 46; Sjögren's syndrome (SS), n = 11; and IgG4-related dacryoadenitis and sialadenitis (IgG4-DS), n = 4, parotitis, n = 6] were enrolled to estimate the parotid gland (PG) and submandibular gland (SMG) PDFF using the Dixon method.
RESULTS:
This volunteer study demonstrated excellent correlation between two methods (R2 = 0.964, slope = 1.05). In the normal group, the PG-PDFF was correlated with the weight and body mass index (BMI) (ρ = 0.38, p = 0.0085; and ρ = 0.63, p < 0.0001). The SMG-PDFF was also correlated with the weight, BMI, and serum triglyceride (ρ = 0.37, p = 0.0067; ρ = 0.42, p = 0.0022; and ρ = 0.35, p = 0.024). The PG-PDFF of the SS group (48.2 ± 15.1%) was higher than that of any other groups; however, no significant difference was found due to the wide overlap. The SS group (39.0 ± 26.14%) also had significantly higher SMG-PDFF than the normal group (8.9 ± 5.4%), p < 0.0001) and IgG4-DS group (3.8 ± 2.3%), p = 0.020).
CONCLUSION:
The Dixon method is a feasible method for estimating the PDFF and demonstrates fat accumulation in SMG in the SS group. Advances in knowledge: The PDFF obtained by the Dixon method is helpful for understanding the salivary gland pathological condition.

DOI： doi: 10.1259/bjr.20170671.

リポジトリ公開URL： https://hdl.handle.net/2324/7218266

記述言語：英語   掲載種別：研究論文（学術雑誌）  

To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the MRS method, and to compared the results.
METHODS:
Sixteen healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, VOIs were set on the bilateral SGs and we obtained the FF (mDIXON) of each VOI.
RESULTS:
There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R2=0.960, slope=0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R2=0.963, slope=1.18). FF (MRS all) was 24.9 ± 12.7% in the PG and 4.5 ± 3.0% in the SMG, while FF (mDIXON) was 29.4 ± 16.2% in the PG and 6.4 ± 4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas.
CONCLUSIONS:
The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.

DOI： doi.org/10.1259/bjr.20160704

記述言語：英語   掲載種別：研究論文（学術雑誌）  

To probe the utility of dynamic contrast-enhanced (DCE) -MRI parameters in assessing the clinical characteristics of oral squamous cell carcinoma.
METHODS:
A total of 85 tumors were included. We applied the Tofts and Kermode model for the DCE-MRI data, and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (Ktrans), the fractional volume of EES per unit volume of tissue (ve) and the fractional volume of plasma (vp). We evaluated the correlations between these parameters and the clinical stages.
RESULTS:
The T stage showed a negative correlation with the Ktrans (r = -0.2272, P = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with Ktrans (r = -0.1948, P = 0.0404), and there were significant differences between N1 and N2+3 (0.119±0.027 min-1 vs 0.096±0.023 min-1, P = 0.0198) and between N0 and N2+3 (0.114±0.29 min-1 vs 0.096±0.023 min-1, P = 0.0288).
CONCLUSIONS:
A decrease in the Ktrans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the Ktrans at the primary site suggested the high possibility of an advanced N stage.

DOI： org/10.1259/bjr.20140814

リポジトリ公開URL： https://hdl.handle.net/2324/7218265

記述言語：英語   掲載種別：研究論文（学術雑誌）  

To elucidate the characteristics of four types of tumors, including squamous cell carcinoma (SCC), malignant lymphoma (ML), malignant salivary gland tumors (MSGTs), and pleomorphic adenoma (Pleo), in the maxillofacial region using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI）data.
MATERIALS AND METHODS:
A total of 59 tumors were included in this research. DCE-MRI and DW-MRI were performed. We applied the Tofts and Kermode model (TK model) for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space from the plasma (K(trans)), the fractional volume of extravascular extracellular space per unit volume of tissue (ve), and the fractional volume of plasma (vp).
RESULTS:
Among the K(trans) values, there were no significant differences between the three types of malignant tumors; however, there was a significant difference between the SCC and Pleo (P = .0099). The ve values of the Pleo were highest, with significant differences compared to the other categories (SCC, P = .0012; ML, P = .0017; and MSGT, P = .041). The ML had the lowest ve values, and there were significant differences between ML and the other two types of malignant tumors (SCC, P = .0278 and MSGT, P = .0062). In 14 (24%) cases, apparent diffusion coefficient (ADC) could not be measured because of poor image quality. The ADC values of the ML were lowest, whereas those of Pleo were highest, similar to that observed for ve.
CONCLUSIONS:
The Pleo tumors had lower K(trans) values and higher ve values, which are useful for differentiating them from the malignant tumors. Moreover, the ve was also useful for establishing a diagnosis of ML.

DOI： org/10.1016/j.acra.2014.08.016

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region.

DOI： doi: 10.1155/2012/480659

リポジトリ公開URL： https://hdl.handle.net/2324/7173603

記述言語：英語   掲載種別：研究論文（学術雑誌）  

口腔扁平上皮ガンにおける、術前科学放射線の治療効果判定を、MRIのダイナミック撮影をコンパートメントモデル解析を用いる事により評価可能であるか検討した。治療高価判定としては、組織学的効果を大星、下里分類を用い、　gold standardとした。コンパートメントモデル解析から得られる、血管外細胞外のスペースveの変化量が、組織学的効果判定と相関する事を明らかにした。すなわわち、腫瘍細胞の減少による血管外細胞外スペースの割合の増加をMRでとらえる事が可能であることを示した。

DOI： doi: 10.1002/jmri.23704

リポジトリ公開URL： https://hdl.handle.net/2324/7218264

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： DOI: 10.1007/s00330-011-2102-x

リポジトリ公開URL： https://hdl.handle.net/2324/7218273

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

リポジトリ公開URL： https://hdl.handle.net/2324/7218272

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

リポジトリ公開URL： https://hdl.handle.net/2324/7218271

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

QUANTITATIVE ANALYSES OF SONOGRAPHIC IMAGES OF THE
PAROTID GLAND IN PATIENTS WITH SJO¨GREN’S SYNDROME

リポジトリ公開URL： https://hdl.handle.net/2324/7218262

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Change of sonographic findings on cervical lymph nodes before and after preoperative radiotherapy

DOI： 10.1007/s00330-003-2173-4

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

Change of sonographic findings on cervical lymph nodes before and after preoperative radiotherapy

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Multivariate feature analysis of sonographic findings of metastatic cervical lymph nodes: contribution of blood flow features revealed by power Doppler sonography for predicting metastasis

記述言語：英語   出版者・発行元：Oral Radiology  

Objective: To summarize the ultrasonography (US) and magnetic resonance imaging (MRI) findings of lymphoepithelial cysts (LECs) and dermoid cysts (DCs) and to discuss the hyperinternal echo in LECs based on histopathological findings. Methods: Patients who underwent US and MRI before resection and whose lesions were pathologically diagnosed as LECs or DCs were included (January 2010 to December 2023). Internal echo, convective flow, and Doppler signals were evaluated on US, while on MRI, we measured the apparent diffusion coefficient (ADC). Results: Surprisingly, all lesions (4 LECs and 7 DCs) had hyperinternal echoes. Convective flow and Doppler signals were observed in 2 of the 4 cases of LEC, and the ADC was high in these cases (2.4 × 10–3 and 2.0 × 10–3 mm2/s). In the two cases where they were not, the ADC was low (1.4 × 10–3 and 0.81 × 10–3 mm2/s). Various cells, such as lymphocyte cells, foam cells, erythroid cells, and keratin, have been found in the cystic cavity, which are thought to be the cause of hyperecho. Considering the ADC, the presence or absence of convection and Doppler signals is thought to reflect the ease of movement of the contents. In the DCs, neither internal convection nor obvious Doppler signals were observed. ADCs were quite low for cysts, which was a characteristic finding (1.1 ± 0.13–3 mm2/s). Conclusion: It is well known that DCs appear hyperechoic on US owing to the presence of keratin; however, it is necessary to recognize that some LECs are depicted as hyperechoic masses and have convective flow and Doppler signals depending on the content.

DOI： 10.1007/s11282-025-00818-1

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PubMed

出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Background and objective: Oral metastases are rare. We experienced a case of oral metastasis of renal cell carcinoma (RCC) and discussed its characteristics with a systematic review to survey the literature for useful features for the diagnosis of oral metastatic RCC. Methods: A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was performed using three databases and the literature of cases of renal cancer metastasis to the jawbone and gingiva. Results: Thirty studies were identified (male-to-female ratio, 2.75:1). The site of metastasis was the jawbone in 66.7 % (mandible, 60 %; maxilla, 6.7 %) and the gingiva in 30 %. Clinical symptoms were a mass in 86.7 % and hypoesthesia in 23.3 %. A total of 76.7 % of oral metastases were clear cell type. In our case, the male patient showed a mass in the maxillary gingiva without hypoesthesia. Metastatic clear cell RCC was suspected by an oral biopsy, which was confirmed on clinical examinations, including a renal biopsy. Conclusion: Oral metastases are rare, and the clinical and imaging findings for oral metastases of RCC are wide-ranged with low specificity, depending on the metastatic site. It is necessary to fully understand the key points in histopathological differentiation. Because the clinician plays a fundamental role in the early diagnosis of oral cancer and the identification of metastatic lesions, awareness of the possibility of rare tumors as in this study can facilitate an accurate preoperative diagnosis and the planning of appropriate treatment.

DOI： 10.1016/j.ajoms.2025.01.004

Scopus

出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Objective: To evaluate useful parameters for differentiating metastatic lymph nodes in oral squamous cell carcinoma using dual-energy computed tomography (DECT) in the venous phase. Methods: A total of 117 lymph nodes without visually obvious necrosis (83 non-metastatic and 34 metastatic) from 40 patients were retrospectively analyzed. The region of interest was defined at the area with the maximum short diameter. Nine parameters were calculated and correlated with the pathology images: CT values of virtual monochromatic X-ray images at 40, 70, and 100 keV (HU40 keV, HU70 keV, HU100 keV), iodine concentration (IC), CT value variation at 40–70 keV (λ40–70HU), 40–100 keV (λ40–100HU), lymph node long diameter, short diameter, and long-short diameter ratio. Results: Metastatic lymph nodes had lower CT and IC values than non-metastatic nodes. However, the short diameter had the highest the area under the receiver operating characteristic curve (AUC) with 0.846 (95 % confidence interval: 0.741–0.914), and the respective sensitivity and specificity were 82.4 % and 84.3 % at a cutoff of 7.54 mm. For parameters using CT values and IC, HU100 keV had the highest AUC (0.737), followed by HU70 keV (0.717), HU40 keV (0.686), IC (0.660), λ40–100HU (0.659), and λ40–70HU (0.659). Six DECT-derived parameters showed the significant negative correlation to the short axis length. Conclusion: In the venous phase, although the significant differences were found in the DECT-derived parameters, the maximal short diameter was found to be the most useful parameter for the differentiation of metastatic lymph nodes.

DOI： 10.1016/j.ajoms.2025.01.012

Scopus

記述言語：英語   出版者・発行元：Dentomaxillofacial Radiology  

Objectives: The purpose of this study was to compare the image quality of ultra-high-resolution CT (U-HRCT) with that of conventional multidetector row CT (convCT) and demonstrate its usefulness in the dentomaxillofacial region. Methods: Phantoms were helically scanned with U-HRCT and convCT scanners using clinical protocols. In U-HRCT, phantoms were scanned in super-high-resolution (SHR) mode, and hybrid iterative reconstruction (HIR) and filtered-back projection (FBP) techniques were performed using a bone kernel (FC81). The FBP technique was performed using the same kernel as in convCT (reference). Two observers independently evaluated the 54 resulting images using a 5-point scale (5 = excellent diagnostic image quality; 4 = above average; 3 = average; 2 = subdiagnostic; and 1 = unacceptable). The system performance function (SPF) was calculated for a comprehensive evaluation of the image quality using the task transfer function and noise power spectrum. Statistical analysis using the Kruskal-Wallis test was performed to compare the image quality among the 3 protocols. Results: The observers assigned higher scores to images acquired with the SHRHIR and SHRFBP protocols than to those acquired with the reference (P < 0.0001 and P < 0.0001, respectively). The relative SPF value at 1.0 cycles/mm in SHRHIR and SHRFBP compared to the reference protocol were 151.5% and 45.6%, respectively. Conclusions: Through phantom experiments, this study demonstrated that U-HRCT can provide superior-quality images compared to conventional CT in the dentomaxillofacial region. The development of a better image reconstruction method is required to improve image quality and optimize the radiation dose.

DOI： 10.1093/dmfr/twae068

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PubMed

記述言語：英語   出版者・発行元：Oral Radiology  

Primary intraosseous carcinoma not otherwise specified (PIOC NOS) is a rare tumor assumed to arise from the epithelium, such as odontogenic cysts or benign tumors. Its clinical and imaging diagnoses are often challenging, especially in the early stages, as it mimics jaw cysts and benign tumors, and no specific findings have been identified. This report presents the case of a 66-year-old male patient with mandibular PIOC, highlighting the imaging findings over time. Magnetic resonance imaging (MRI) before symptom onset showed a cystic lesion in the right mandible with a soft tissue component. Both the fluid component and soft tissue exhibited low apparent diffusion coefficient values (1.0 × 10–3 mm2/s and 1.3 × 10–3 mm2/s, respectively). Subsequent MRI approximately 5 months later during symptom onset showed a slight increase in the soft tissue component. Based on the clinical and imaging findings, ameloblastoma was suspected, prompting a biopsy for confirmation. However, the histopathological findings showed squamous cell carcinoma (SCC). MRI performed approximately 1 month later exhibited significant tumor growth and extension beyond the jawbone, consistent with a malignant tumor. Histopathological examination identified areas with a basal layer in a palisading arrangement, indicating a pre-existing odontogenic cyst, and showed a transition from epithelial dysplasia to SCC. In addition, carcinoma cell invasion and proliferation into the cyst were observed. Based on these findings, PIOC of the right mandible was determined to be the definitive diagnosis.

DOI： 10.1007/s11282-024-00788-w

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PubMed

記述言語：英語   出版者・発行元：Elsevier  

Background/purpose / Radiolucent lesions of the mandible, including ameloblastoma, odontogenic keratocyst (OKC), dentigerous cyst (DC) and simple bone cyst (SBC), are frequently encountered in clinical practice. However, they vary in type and occasionally in appearance. Each lesion needs a different treatment and approach; therefore, accurate diagnosis is crucial before treatment. However, the radiographic findings, including computed tomography (CT), are often similar. This study aimed to compare the CT findings of 41 ameloblastomas, 74 OKCs, 87 DCs, and 13 SBCs in the mandible. / / Materials and methods / Patients were evaluated on initial CT images focusing on features such as long/short diameters, relationship with adjacent teeth, cortex appearance, locularity, scalloped margins, and sclerotic rims. Multivariate logistic regression analysis was performed to determine the most useful features for differential diagnosis. Criteria for differential diagnosis were finally established for three lesions, excluding SBC, which had a relatively small number of cases. / / Results / The relationship with the affected tooth, short diameters, sclerotic rims, and locularity were found to be significant features in the differential diagnosis. Ameloblastomas were characterized by relatively larger short diameters, frequently accompanied by root resorption and adjacent tooth displacement, while SBCs lacked these features. Sclerotic rims were commonly observed in OKCs and DCs, and most DCs were unilocular, containing a crown within the lesion. Based on these results, criteria were established for differential diagnosis with a diagnostic accuracy of 84.2%. / / Conclusion / This is the first study to attempt to characterize each lesion's radiological features, and these criteria are likely to assist in clinical diagnosis.

CiNii Research

記述言語：英語   出版者・発行元：Oral Radiology  

We report an unusual case of carcinoma ex pleomorphic adenoma (CXPA) in the submandibular gland. The mass had a unique calcification. Panoramic tomography revealed sponge-like calcification. The central portion displayed heterogeneous high signal intensity on T1-weighted image (T1WI) and T2-weighted image (T2WI), and heterogeneously moderate signal intensity on a short-TI inversion recovery (STIR) image. The ADC was low (0.78 × 10−3mm2/sec). After surgical excision, a pathological examination revealed that the mass contained CXPA as a minor component. Tumor cells with large hyperchromatic nuclei and eosinophilic or clear cytoplasm proliferated in irregular small tubule formations or cribriform or Roman-bridge structures in hyalinized or focally ossified stroma. The entire mass was calcified, particularly in the central region. Taken together, the reduced T1 relaxation times were related to the surface effects of diamagnetic particles, which were observed at calcium particle concentrations of up to 30%. We report a CXPA with unusual sponge-like calcification, which appeared unusually hyperintense on T1WI due to a surface effect.

DOI： 10.1007/s11282-023-00724-4

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PubMed

記述言語：英語   出版者・発行元：(NPO)日本歯科放射線学会  

顎下腺から生じた異常な海綿様石灰化を伴う悪性多形性腺腫(CXPA)の稀少症例について報告した。症例は64歳女性で、義歯治療に関連した症状により紹介来院された。パノラマX線断層撮影により右顎下腺に海綿様の石灰化が認められ、中心部分はT1WI画像およびT2WI画像では不均一な高信号、short-TI inversion recovery(STIR)画像では不均一な中等度の信号強度で描出され、見かけの拡散係数は低値(0.78×10^-3mm2/s)であった。外科的切除後の病理学検査により、腫瘤は微量成分としてCXPAを含み、大型で過染色性の核と好酸性や淡明な細胞質を有する腫瘍細胞が、ヒアリン化または焦点的に骨化した間質で不規則な小型の管状もしくは篩状、Roman-bridge様構造内で増殖していた。また、腫瘤全体は石灰化され、特に中心領域の石灰化が顕著であった。本例から、T1緩和時間の短縮が、30%までのカルシウム粒子濃度で観察される反磁性粒子の表面効果と関連することが明らかにされた。

記述言語：英語   出版者・発行元：Journal of Dental Sciences  

Background/purpose: Radiolucent lesions of the mandible, including ameloblastoma, odontogenic keratocyst (OKC), dentigerous cyst (DC) and simple bone cyst (SBC), are frequently encountered in clinical practice. However, they vary in type and occasionally in appearance. Each lesion needs a different treatment and approach; therefore, accurate diagnosis is crucial before treatment. However, the radiographic findings, including computed tomography (CT), are often similar. This study aimed to compare the CT findings of 41 ameloblastomas, 74 OKCs, 87 DCs, and 13 SBCs in the mandible. Materials and methods: Patients were evaluated on initial CT images focusing on features such as long/short diameters, relationship with adjacent teeth, cortex appearance, locularity, scalloped margins, and sclerotic rims. Multivariate logistic regression analysis was performed to determine the most useful features for differential diagnosis. Criteria for differential diagnosis were finally established for three lesions, excluding SBC, which had a relatively small number of cases. Results: The relationship with the affected tooth, short diameters, sclerotic rims, and locularity were found to be significant features in the differential diagnosis. Ameloblastomas were characterized by relatively larger short diameters, frequently accompanied by root resorption and adjacent tooth displacement, while SBCs lacked these features. Sclerotic rims were commonly observed in OKCs and DCs, and most DCs were unilocular, containing a crown within the lesion. Based on these results, criteria were established for differential diagnosis with a diagnostic accuracy of 84.2%. Conclusion: This is the first study to attempt to characterize each lesion's radiological features, and these criteria are likely to assist in clinical diagnosis.

DOI： 10.1016/j.jds.2024.04.013

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi.org/10.1007/s11282-023-00724-4

出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

Metastatic tumors in the oral cavity are rare, accounting for only 1% of all oral malignancies. The most common site of metastatic tumors in the oral cavity is the mandibular molar region. The primary sites differ between the sexes. Among men, the primary sites are the lung, kidney, liver, and prostate in the order of frequency. Moreover, 11% of jawbone metastases among men originate from the prostate gland. Symptoms differ according to the location of the metastasis; besides, metastases-related imaging findings are nonspecific, making it difficult to reach an accurate diagnosis. Metastatic oral cancer has a poor prognosis; therefore, early diagnosis and treatment are important to improve the survival-rate and quality of life. A 76-year-old male patient was referred to our hospital with complaint of right-sided mandibular swelling and past medical history of adenocarcinoma of the prostate gland. Intraoral examination revealed a hard hemispherical mass on the right mandibular first molar region. Computed tomography showed a well-marginated radiopaque hemisphere mass with a typical sunburst periosteal reaction. Based on the imaging findings, we suspected primary osteosarcoma or metastatic prostate cancer. Histopathological examination of the mandible revealed a glandular structure with atypia similar to that of the primary prostate cancer cells. After prostate specific antigen monitoring therapy, the metastatic cancer did not grow. Metastatic cancers from other organs should be considered in the differential diagnosis of jawbone malignancies because the metastatic cancer might present similarities to the primary cancer in imaging findings, as in the present case that clinically mimicked osteosarcoma.

DOI： 10.1016/j.ajoms.2023.01.009

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記述言語：英語   出版者・発行元：エルゼビア・ジャパン(株)  

症例は76歳男性。4ヵ月前に自覚した下顎右側の腫脹を主訴に紹介受診した。5年前には前立腺の腺癌(T3N0M0、Gleasonスコア7(3+4))に対し放射線療法と内分泌療法を受けていた。その後は泌尿器科を定期的に受診していたが、ここ1年間で前立腺特異抗原(PSA)の検査値が1.2から83.5ng/mlまで上昇してきていた。そのため2ヵ月前に骨シンチグラフィー検査が行われ、下顎右側に99mTcの異常集積像が示されたが、これは歯周炎と診断され追加の検査は施行されなかった。当院での診察では下顎右側臼歯領域に相当する体表に硬腫瘤を認め、口腔内診察では下顎右側第1大臼歯領域に40×35mm大で半球状の硬腫瘤が観察された。CT検査では半球状で境界が明瞭な不透過性腫瘤が描出された。その像には典型的な陽光状(sunburst)骨膜反応が認められた。こうした画像所見から原発性骨肉腫または転移性前立腺癌を疑った。PET検査では右下顎、胸骨、第7肋骨、右腸骨にFDGの異常集積像が示された。右下顎病変へのコア生検を施行した結果から、上記の各部位への転移性前立腺癌と診断した。患者は化学療法を拒んだためPSA監視療法と内分泌療法を行ったところ、PSA値は直ちに21.1ng/mlまで低下した。治療開始からの7年間でPSAは良好にコントロールされ、転移癌の進行はみられなかった。

記述言語：英語   出版者・発行元：Oncology Letters  

Synovial sarcoma (SS) is a malignant soft tissue tumor that usually arises in the para‑articular regions of the extremities. Only nine cases of SS in the mandible have been reported to date. The present study described a case of SS arising from the left mandible. A 54‑year‑old woman was referred to Kyushu University Hospital (Fukuoka, Japan) with a complaint of numbness in the left mental nerve area. Computed tomography revealed replacement of the left mandibular bone marrow with soft tissue and destruction of the mandibular canal. Magnetic resonance imaging revealed an isointense mass on T1‑weighted images and hyperintensity on T2‑weighted images. The tumor showed homogeneous enhancement. A biopsy was performed, and monophasic SS was diagnosed based on immunohistochemical staining features and genetic analysis. Hemimandible dissection and supraomophyoid neck resection were performed with fibular osteocutaneous flap reconstruction, followed by adjuvant chemotherapy. There was no evidence of recurrence or distant metastases. The present study also reviewed the clinical, imaging, histological, and immunohistochemical features of the SS in the mandible.

DOI： 10.3892/ol.2023.13904

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CiNii Research

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Metastatic tumors in the oral cavity are rare, accounting for only 1% of all oral malignancies. The most common site of metastatic tumors in the oral cavity is the mandibular molar region. The primary sites differ between the sexes. Among men, the primary sites are the lung, kidney, liver, and prostate in the order of frequency. Moreover, 11% of jawbone metastases among men originate from the prostate gland. Symptoms differ according to the location of the metastasis; besides, metastases-related imaging findings are nonspecific, making it difficult to reach an accurate diagnosis. Metastatic oral cancer has a poor prognosis; therefore, early diagnosis and treatment are important to improve the survival-rate and quality of life. A 76-year-old male patient was referred to our hospital with complaint of right-sided mandibular swelling and past medical history of adenocarcinoma of the prostate gland. Intraoral examination revealed a hard hemispherical mass on the right mandibular first molar region. Computed tomography showed a well-marginated radiopaque hemisphere mass with a typical sunburst periosteal reaction. Based on the imaging findings, we suspected primary osteosarcoma or metastatic prostate cancer. Histopathological examination of the mandible revealed a glandular structure with atypia similar to that of the primary prostate cancer cells. After prostate specific antigen monitoring therapy, the metastatic cancer did not grow. Metastatic cancers from other organs should be considered in the differential diagnosis of jawbone malignancies because the metastatic cancer might present similarities to the primary cancer in imaging findings, as in the present case that clinically mimicked osteosarcoma.

DOI： https://doi.org/10.1016/j.ajoms.2023.01.009

記述言語：英語   出版者・発行元：European Radiology  

Objectives: To compare the delineation of mandibular cancer by 3D T1 turbo field echo with compressed SENSE (CS-3D-T1TFE) images and MDCT images, and to compare both sets of images with histopathological findings, as the gold standard, to validate the accuracy and clinical usefulness of CS-3D-T1TFE reconstruction. Methods: Twenty-four patients with mandibular squamous cell carcinoma (SCC) who underwent MRI including CS-3D-T1TFE and MDCT examinations before surgery were retrospectively included. For both examinations, 0.5-mm-thick coronal plane images and 0.5-mm-thick plane images perpendicular and parallel to the dentition were constructed. Two radiologists rated bone invasion in three categories indexed by cortical bone, cancellous bone, and mandibular canal (MC), and inter-rater agreement was assessed by weighted kappa statistics. In 20 of the 24 patients who underwent surgery, the correlation of bone invasion with the histopathological evaluation by pathologists was assessed using Pearson’s correlation coefficient. Soft-tissue invasion was assessed by diagnosing the presence of invasion into the mylohyoid muscle, gingivobuccal fold, and masticator space, and inter-rater agreement was assessed by kappa statistics. Results: The interobserver agreement for bone invasion assessment was almost perfect with CS-3D-T1TFE and substantial with MDCT. The image evaluations by both observers agreed with the pathological evaluations in 15 of the 20 cases, showing high correlation (r > 0.8). CS-3D-T1TFE also showed higher inter-rater agreement than MDCT for all measures of soft-tissue invasion. Conclusions: CS-3D-T1TFE reconstructed images were clinically useful in accurately depicting the extent of mandibular cancer invasion and potentially solving the problem of lesion overestimation associated with conventional MRI. Key Points: • Reconstructed CS-3D-T1TFE images were useful for the diagnosis of mandibular cancer. • CS-3D-T1TFE images showed higher inter-rater agreement than MDCT and high correlation with pathological findings. • CS-3D-T1TFE images may solve the problem of overestimation of the tumor extent, which has been associated with MRI in the past.

DOI： 10.1007/s00330-022-09075-w

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記述言語：英語   出版者・発行元：エルゼビア・ジャパン(株)  

下顎骨の歯原性角化嚢胞(OKC)およびエナメル上皮腫のCT所見を比較した。2007～2021年に当院を受診したOKC患者41名とエナメル上皮腫患者28名を組み入れた。初診時のCT画像を評価した結果、両病理を鑑別診断する有意な特徴として、病巣の短径と単房性/多房性の違いが同定された。単嚢胞型エナメル上皮腫と通常型エナメル上皮腫の間では、硬化縁および頬側皮質骨消失の所見頻度に有意差が認められた。得られた所見に基づき、OKCとエナメル上皮腫を鑑別診断するための基準を作成したところ、その診断精度は92.8%となった。以上から、いくつかのCT所見はOKCとエナメル上皮腫の間ではっきり異なることが示された。

記述言語：日本語   出版者・発行元：特定非営利活動法人 日本歯科放射線学会  

In Japan, 3T MRI was approved in 2003 under the Pharmaceutical Affairs Law. The spread of 3T equipment has since progressed due to improvements in hardware and software. On the other hand, the head and neck have many conditions that are disadvantageous for MRI usage due to factors such as involuntary movements, inhomogeneous magnetic fields due to the presence of metal prostheses and air spaces, and complex anatomy. As radial sampling is useful for motion compensation, it has been incorporated into many MR units. Static magnetic field correction is useful for reducing metal artifacts, which also leads to improvement of fat-suppressed imaging.
<br>In this review, we summarize the effects of 3T equipment on image quality and methods for addressing problems specific to the maxillofacial region, and present specific clinical applications.
<br>As an example of clinical application, we introduce contrast-enhanced T1-weighted imaging using compressed sensing and distortion-free diffusion-weighted imaging. Next, for assessing biochemical information, we introduce the estimation of fat fraction using the six-point Dixon method and trace components using the chemical exchange saturation transfer effect.

DOI： 10.11242/dentalradiology.63.1

CiNii Research

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Spandidos Publications  

Mixed tumor of the skin (MTS) is a rare neoplasm derived from the sweat glands with a reported frequency of 0.01-0.098% among all primary skin tumors. MTS often occurs in the head and neck region and is characterized by a mixture of epithelial, myoepithelial and stromal components. MTS also shows various morphological patterns, thus the presence of variants with rare components and its rarity make the clinical diagnosis even more difficult. A 47-year-old man was referred due to a painless, slowly growing, exophytic swelling intracutaneous mass of the upper lip. Magnetic resonance imaging revealed that the mass was a solid tumor with a fatty component in the proximal portion, while the distal portion was cystic and possibly contained highly viscous fluid. The mass was located between the skin and the orbicularis oris muscle in the upper lip. Excisional biopsy was performed and the lesion showed two intriguing features: A tumor with extensive lipomatous stroma and some large cysts. It was histopathologically diagnosed as lipomatous MTS with cystic formation in the upper lip. No evident signs of recurrence were observed during follow-up. The present report describes this case and includes a brief literature review of reported cases in the lip, since MTS can be confused with various skin lesions in clinical settings due to this rarity. Recognition by clinicians of different variants of MTSs, including the present case, is important for preventing erroneous diagnosis and treatment.

DOI： 10.3892/etm.2022.11600

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：International Journal of Oral and Maxillofacial Surgery  

The aim of this study was to clarify the correlation between imaging findings obtained using intraoral ultrasonography (US) and pathological findings of tongue cancers, and to examine the predictive value of intraoral US findings with respect to occult nodal metastasis. This was a retrospective study based on the medical records of 123 patients with T1–2N0 tongue cancer. The depth of invasion (DOI) on intraoral US was positively correlated with the pathological invasion depth (PID) (ρ = 0.7080, P < 0.0001). Receiver operating characteristic analyses revealed an optimal DOI cut-off value of 4.1 mm and optimal PID cut-off value of 3.9 mm to detect nodal metastasis. Regarding the margin shape of the primary tumour on intraoral US, the incidence of nodal metastasis was significantly higher for the permeated type than for the pressure type (P < 0.001) and wedge-shaped type (P = 0.002). Furthermore, tumours with peritumoural vascularity assessed by power Doppler US had a significantly higher incidence of nodal metastasis than tumours without (P = 0.003). The sensitivity, specificity, and accuracy of the permeated type to predict nodal metastasis was 53.6%, 95.8%, and 86.2%, respectively. These results suggest that intraoral US findings closely reflect pathological findings and could be useful to predict occult nodal metastasis in patients with early-stage tongue cancer.

DOI： 10.1016/j.ijom.2022.08.021

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記述言語：英語   出版者・発行元：Dentomaxillofacial Radiology  

Objectives: To compare the gamma distribution (GD), intravoxel incoherent motion (IVIM), and monoexponential (ME) models in terms of their goodness-of-fit, correlations among the parameters, and the effectiveness in the differential diagnosis of various orofacial lesions. Methods: A total of 85 patients underwent turbo spin-echo diffusion-weighted imaging with six b-values. The goodness-of-fit of three models was assessed using Akaike Information Criterion. We analysed the correlations and compared the effectiveness in the differential diagnosis among the parameters of GD model (κ, shape parameter; θ, scale parameter; fractions of diffusion: ƒ1, cellular component; ƒ2, extracellular diffusion; ƒ3, perfusion component), IVIM model (D, true diffusion coefficient; D*, pseudodiffusion coefficient; f, perfusion fraction), and ME model (apparent diffusion coefficient, ADC). Results: The GD and IVIM models showed a better goodness-of-fit than the ME model (p < 0.05). ƒ1 had strong negative correlations with D and ADC (ρ = -0.901 and -0.937, respectively), while ƒ3 had a moderate positive correlation with f (ρ = 0.661). Malignant entity presented significantly higher ƒ1 and lower D and ADC than benign entity (p < 0.0001). Malignant lymphoma had significantly higher ƒ1 in comparison to squamous cell carcinoma (p = 0.0007) and granulation (p = 0.0075). The trend in ƒ1 was opposite to the trend in D. Malignant lymphoma had significant lower ƒ3 than squamous cell carcinoma (p = 0.005) or granulation (p = 0.0075). Conclusions: The strong correlations were found between the GD- and IVIM-derived parameters. Furthermore, the GD model's parameters were useful for characterising the pathological structure in orofacial lesions.

DOI： 10.1259/dmfr.20200609

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記述言語：英語   出版者・発行元：British Journal of Radiology  

Objective: To determine whether the γ distribution (GD) model of diffusion MRI is useful in the evaluation of the isocitrate dehydrogenase (IDH) mutation status of glioblastomas. Methods: 12 patients with IDH-mutant glioblastomas and 54 patients with IDH-wildtype glioblastomas were imaged with diffusion-weighted imaging using 13 b-values from 0 to 1000 s/mm2. The shape parameter (κ) and scale parameter (θ) were obtained with the GD model. Fractions of three different areas under the probability density function curve (f1, f2, f3) were defined as follows: f1, diffusion coefficient (D) < 1.0×10−3 mm2/s; f2, D > 1.0×10−3 and <3.0×10−3 mm2/s; f3, D > 3.0 × 10−3 mm2/s. The GD model-derived parameters measured in gadolinium-enhancing lesions were compared between the IDH-mutant and IDH-wildtype groups. Receiver operating curve analyses were performed to assess the parameters' diagnostic performances. Results: The IDH-mutant group’s f1 (0.474 ± 0.143) was significantly larger than the IDH-wildtype group’s (0.347 ± 0.122, p = 0.0024). The IDH-mutant group’s f2 (0.417 ± 0.131) was significantly smaller than the IDH-wildtype group’s (0.504 ± 0.126, p = 0.036). The IDH-mutant group’s f3 (0.109 ± 0.060) was significantly smaller than the IDH-wildtype group’s (0.149 ± 0.063, p = 0.0466). The f1 showed the best diagnostic performance among the GD model-derived parameters with the area under the curve value of 0.753. Conclusion: The GD model could well describe the pathological features of IDH-mutant and IDH-wildtype glioblastomas, and was useful in the differentiation of these tumors. Advances in knowledge: Diffusion MRI based on the γ distribution model could well describe the pathological features of IDH-mutant and IDH-wildtype glioblastomas, and its use enabled the significant differentiation of these tumors. The γ distribution model may contribute to the non-invasive identification of the IDH mutation status based on histological viewpoint.

DOI： 10.1259/bjr.20210392

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

This study aims to quantitatively evaluate the effect of additional copper-filters (Cu-filters) on the radiation dose and contrast-to-noise ratio (CNR) in a dental cone beam computed tomography (CBCT). The Cu-filter thickness and tube voltage of the CBCT unit were varied in the range of 0.00-0.20 mm and 70-90 kV, respectively. The CBCT images of a phantom with homogeneous materials of aluminum, air, and bone equivalent material (BEM) were acquired. The CNRs were calculated from the voxel values of each homogeneous material. The CTDIvol was measured using standard polymethyl methacrylate CTDI test objects. We evaluated and analyzed the effects of tube current and various radiation qualities on the CNRs and CTDIvol. We observed a tendency for higher CNR at increasing tube voltage and tube current in all the homogeneous materials. On the other hand, the CNR reduced at increasing Cu-filter thickness. The tube voltage of 90 kV showed a clear advantage in the tube current-CNR curves in all the homogeneous materials. The CTDIvol increased as the tube voltage and tube current increased and decreased with the increase in the Cu-filter thickness. When the CNR was fixed at 9.23 of BEM at an exposure setting of 90 kV/5 mA without a Cu-filter, the CTDIvol at 90 kV with Cu-filters was 8.7% lower compared with that at 90 kV without a Cu-filter. The results from this study demonstrate the potential of adding a Cu-filter for patient dose reduction while ensuring the image quality.

DOI： doi: 10.1016/j.ejmp.2020.11.022.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background
Although magnetic resonance imaging (MRI) provides excellent soft-tissue contrast, long acquisition times are major disadvantages.

Purpose
To evaluate the usefulness of compressed sensing (CS) for contrast-enhanced oral and maxillofacial MRI by comparing the 3D T1 turbo field echo with compressed SENSE (CS-3D-T1TFE) sequence with the multi-slice spin echo (MS-SE) sequence as the reference standard.

Material and Methods
Thirty patients with orofacial lesions participated in this study. The scan times for MS-SE and CS-3D-T1TFE were 5 min 56 s and 1 min 43 s, respectively. The signal-to-noise ratio (SNR) was calculated for quantitative analysis and seven parameters (degree of lesion conspicuity, motion artifacts, metal artifacts, pulsation artifacts, quality of fat suppression, homogeneity of blood vessel signal intensity, and overall image quality) were evaluated using a 5-point scale (5 = excellent, 1 = unacceptable) by two observers for qualitative analysis. For comparisons between MS-SE and CS-3D-T1TFE, the paired t-test was used.

Results
The SNR of CS-3D-T1TFE was higher than or equal to that of MS-SE. The CS-3D-T1TFE scores for motion artifacts, pulsation artifacts, and homogeneity of blood vessel signal intensity were higher than the corresponding MS-SE scores in assessments by both observers. The MS-SE scores for fat suppression were higher than or equal to the CS-3D-T1TFE scores. There were no significant differences in lesion conspicuity, metal artifacts, and overall image quality between the two sequences.

Conclusion
CS-3D-T1TFE imaging, less than 30% of the scan time for MS-SE, showed no image degradation while retaining equal or higher SNR and image quality.

DOI： https://doi.org/10.1177/2058460120956644

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ajoms.2019.04.002

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Dental cone-beam computed tomography (CBCT) received regulatory approval in Japan in 2000 and has been widely used since being approved for coverage by the National Health Insurance system in 2012. This imaging technique allows dental practitioners to observe and diagnose lesions in the dental hard tissue in three dimensions (3D). When performing routine radiography, the examination must be justified, and optimal protection should be provided according to the ALARA (as low as reasonably achievable) principles laid down by the International Commission on Radiological Protection. Dental CBCT should be performed in such a way that the radiation exposure is minimized and the benefits to the patient are maximized. There is a growing demand for widespread access to cutting-edge health care through Japan’s universal health insurance system. However, at the same time, people want our limited human, material, and financial resources to be used efficiently while providing safe health care at the least possible cost to society. Japan’s aging population is expected to reach a peak in 2025, when most of the baby boomer generation will be aged 75 years or older. Comprehensive health care networks are needed to overcome these challenges. Against this background, we hope that this text will contribute to the nation’s oral health by encouraging efficient use of dental CBCT.

DOI： 10.1007/s11282-018-0314-3

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: Though the motions of structures outside the mouth in trumpet performance have been reported, the dynamics of intraoral structures remain unelucidated. This study explored the tongue's movement in trumpet playing using cine magnetic resonance imaging (cine MRI) and demonstrated the effects of intraoral anatomical structures on changes in pitch and dynamics. METHODS: Cine MRI was applied to 18 trumpet players, who were divided into two groups (7 beginner, 11 advanced) based on their ability to play a certain high note. They were instructed to play a custom-made MRI-compatible simulated trumpet. Pitch-change tasks and dynamics-change tasks were assigned. The positions of the anatomical points and intraoral areas were identified on outlined images, and the changes associated with each task were evaluated. RESULTS: A forward and upward projection of the tongue was observed in the production of higher pitches, and there were no significant differences in all areas. In louder dynamics, a backward and downward bending of the tongue occurred, the tongue area became smaller (p<0.001), and the oral cavity area became larger (p<0.001). No significant differences between beginner and advanced trumpet players were seen in the changes in pitch and dynamics. CONCLUSION: It was demonstrated using cine MRI that certain tongue movements were associated with each task. Tongue protrusion in the production of higher pitch and bending in louder dynamics can be rationalized using acoustics theory and the movements of anatomical structures. These findings seem to be consistent regardless of the player's proficiency.

DOI： 10.21091/mppa.2017.4038

リポジトリ公開URL： http://hdl.handle.net/2324/4481551

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The administration of pre-operative chemotherapy with S-1 and concurrent radiotherapy at a total dose of 30 Gy was clinicopathologically evaluated as a treatment for locally advanced oral squamous cell carcinoma (OSCC) in the present study. The participants comprised 81 patients with OSCC, consisting of 29 patients with stage II disease, 12 patients with stage III disease and 40 patients with stage IV disease. All patients received a total radiation dose of 30 Gy in daily fractions of 2 Gy, 5 times a week, for 3 weeks, and the patients were concurrently administered S-1 at a dose of 80-120 mg, twice daily, over 4 consecutive weeks. Radical surgery was performed in all cases at 2-6 weeks subsequent to the end of pre-operative chemoradiotherapy. The most common adverse event was oropharyngeal mucositis, but this was transient in all patients. No severe hematological or non-hematological toxicities were observed. The clinical and histopathological response rates were 70.4 and 75.3%, respectively. Post-operatively, local failure developed in 6 patients (7.4%) and neck failure developed in 2 patients (2.5%). Distant metastases were found in 7 patients (8.6%). The overall survival rate, disease-specific survival rate and locoregional control rate at 5 years were 87.7, 89.9 and 90.6%, respectively. Locoregional recurrence occurred more frequently in patients that demonstrated a poor histopathological response compared with patients that demonstrated a good response (P<0.01). These results indicate that pre-operative S-1 chemotherapy with radiotherapy at a total dose of 30 Gy is feasible and effective for patients with locally advanced OSCC, and that little or no histopathological response may be a risk factor for locoregional recurrence in this treatment.

DOI： 10.3892/ol.2016.4411

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. Methods and Results A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. Conclusion These findings suggest that bony materials are associated with dystrophic calcification.

DOI： 10.1002/hed.24036

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Abstract
Objectives To compare magnetic resonance imaging (MRI) findings between patients with malignant lymphoma (ML) and squamous cell carcinoma (SCC) in the head and neck regions, and to show the characteristic findings for ML.
Methods We analyzed 10 lesions in nine patients with ML and 25 lesions in 25 patients with SCC. Diffusion- weighted imaging, T1-weighted imaging, and T2-weighted imaging were performed for all lesions. We estimated the apparent diffusion coefficients (ADCs) with b-factors of 0, 500, and 1000 s/mm2, and obtained the means and standard deviations. In 29 cases, dynamic contrast-enhanced MRI (DCE-MRI) was performed and time–intensity curves were obtained. The peak time, maximum-to-initial ratio (MI ratio), end-to-maximum ratio, and end-to-initial ratio (EI ratio) were estimated. Receiver-operating characteristic analyses were performed to estimate the diagnostic power for these indices.
Results The mean ADC for ML (0.762 ± 0.126 9 10-3 mm2/s) was significantly lower than that for SCC (1.24 ± 0.22 9 10-3 mm2/s, p \ 0.0001). ML had a smaller MI ratio (2.13 ± 0.26) and smaller EI ratio (1.90 ± 0.29) than SCC (MI ratio: 2.46 ± 0.38, p = 0.033; EI ratio: 2.19 ± 0.29, p = 0.025). The area under the curve for the mean ADC (0.989) was higher than those for the MI ratio (0.779) and EI ratio (0.792). Conclusions The most characteristic findings for ML were extremely low ADCs. If the ADCs cannot be esti- mated because of severe susceptibility artifacts, DCE-MRI provides an alternative index for differentiating ML from SCC.

DOI： 10.1007/s11282-015-0219-3

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin lymphoma. It develops in the outer edge of a lymph node called the mantle zone. In contrast, IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by elevated serum IgG4 and persistent bilateral enlargement of lacrimal glands (LGs) and salivary glands (SGs), with infiltration of IgG4-positive plasma cells. Recent studies indicated the importance of differentiation between IgG4-DS and malignant lymphoma. Case presentation: An 82-year-old man was suspected of IgG4-DS because of a high serum IgG level (2174 mg/dL) and bilateral swelling of LGs and SGs. Lip biopsy and fine needle biopsy of submandibular gland were performed, and subsequently, MCL was diagnosed through the histopathological findings. Conclusions: MCL most commonly occurs in the Waldeyer ring, but rarely in the stomach, spleen, skin, LG, and SG. We report an unusual case of MCL involving LGs and SGs mimicking IgG4-DS, which suggests that IgG4 testing may be useful in the differentiation of IgG4-DS in the presence of bilateral swelling of LGs or SGs.

DOI： 10.1186/s12957-015-0644-0

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective
This study aimed at clarifying whether we can differentiate dentigerous cysts with calcified substances from other odontogenic tumors that include calcification and the crown of an unerupted tooth by CT findings.
Methods
We retrospectively selected histopathologically confirmed cases that included calcified substances and the crown of an unerupted tooth inside. There were 22 cases with eight pathological categories. Besides seven odontogenic tumors, we included dentigerous cysts, which were usually recognized without calcification within the lesions. We divided the cases into two groups: 14 cases of odontogenic tumors and 8 cases of dentigerous cysts. Cases were analyzed for various CT findings such as continuity with the alveolar crest, bone sclerosis around the lesion, and sizes and shapes of high CT value substances, as well as demographic factors. Comparisons between the groups for each analytical factor were performed.
Results
Dentigerous cysts with dystrophic calcification showed unique CT findings such as bone sclerosis around the lesion, continuity with the alveolar crest, and small scattered calcified substances near the crown of an unerupted tooth, compared with typical dentigerous cysts and other odontogenic tumors. On the other hand, odontogenic tumors showed various patterns in the location and distribution of high CT value substances, and we could only differentiate odontoma using its very high CT values.
Conclusion
Although the patterns of calcification were not the main characteristic findings, it may be possible to differentiate dentigerous cysts with dystrophic calcification from odontogenic tumors by their other characteristic CT findings, and unnecessary extensive surgery can also be avoided.

DOI： 10.1007/s11282-014-0173-5

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Diffusion Weighted Image (DWI) has various roles such as tissue characterization, the prediction and monitoring of the response to treatment and
differentiation of recurrent tumors from post-therapeutic changes. The malignant tumors have a lower ADC compared to benign lesions. Follow-up of early
response to cancer treatment is reflected in an ADC increase in the primary tumor and nodal metastases; whereas nonresponding lesions tend to reveal only
a slight increase or even a decrease in ADC during follow-up. However, there are many limitations regarding the performance of DWI in the head and neck
region, therefore, many attempts has been performed to overcome the flaws of the diffusion-weighted single-shot-echo planar imaging.
The pharmacokinetic analyses of dynamic contrast enhanced MRI (DCE-MRI) can provide physiological condition of the tissue, and Tofts and Kermode
Model has been applied to the head and neck region. Some researchers have used it for the prediction and monitoring of the tumor response to cancer therapy.
The general consensus is that the early changes of these parameters during the early phase after the treatment are useful for the interpretation of the response
to the treatment. However, the parameters reported in the literature vary considerably; therefore, it is difficult to compare the values of the parameters among
research groups.
Both DWI and the pharmacokinetic analysis of the DCE-MRI have shown a wide range of potential benefits in this region, but more comparative studies
with established scan techniques and the quantification of the data are required.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The aim of this study was to display the lingual artery superimposed on the anatomical image and to confirm its course and relation to the adjacent structures, noninvasively. Nineteen volunteers participated in the magnetic resonance imaging (MRI) study and one was excluded for excessive movement during scanning. A three-dimensional phase-contrast sequence (3D-PC) of magnetic resonance angiography (MRA) was used for vessel images, and a 3D-T1 high-resolution volume examination (THRIVE) was used for anatomical images. Colour-coded vessel images from 3D-PC MRA were superimposed on the 3D volume anatomical images, and the arterial course and relation to the adjacent structures were confirmed with multiplanar reconstructed cross-sectional (MPR) images. 3D-PC MRA images visualized the lingual artery in all 18 subjects and the sublingual artery in 14 subjects. In seven of 18 cases the bilateral sublingual arteries were shown to run side by side but had no contact with the sublingual veins. They ran together with the sublingual veins in four cases. Three cases showed irregular patterns. The bilateral sublingual arteries could not be identified in four cases. 3D-PC MRA images of the lingual artery superimposed on the anatomical images may be clinically useful to confirm its course and relationship to the adjacent structures before surgery, in order to prevent haemorrhage.

DOI： 10.1016/j.ijom.2013.04.011

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.

DOI： 10.1186/1477-7819-11-234

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.Case report: A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively.Conclusion: This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.

DOI： 10.1186/1477-7819-11-234

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

一般臨床医のみならず歯科放射線科医にとってもＣＢＣＴの各機種の長短を詳細に把握する事は困難である．さらに，一般臨床医には，専門用語や，装置のテクニカルな面など不慣れな部分も多い．しかしながら，CBCTの性能を考える時には重要なポイントが数点ある．まず，画質に関しては，１．空間分解能，２．コントラスト，３．粒状性である．これらの点に関しての解説を行った.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-011-0068-7

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1259/dmfr/81000210

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Is glossectomy necessary for late nodal metastases without clinical local recurrence after initial brachytherapy for N0 tongue cancer? A retrospective experience in 111 patients who received salvage therapy for cervical failure.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Sonographic texture characterization of salivary gland tumors by fractal analyses.

DOI： 10.1016/j.ultrasmedbio.2005.05.012

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tripleo.2004.02.054

リポジトリ公開URL： https://hdl.handle.net/2324/7218270

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Intraoral sonographic features of tongue cancer after radical radiotherapy

DOI： 10.1016/j.ejrad.2004.01.012

リポジトリ公開URL： https://hdl.handle.net/2324/7218268

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Possibility of sialographic sonography: a Doppler phantom study

DOI： 10.1067/moe.2001.113832

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The combined use of US and MR imaging for the diagnosis of masses in the parotid region

DOI： 10.1080/028418501127346305

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Tumor recurrence criteria for postoperative contrast-enhanced computed tomography after surgical treatment of oral cancer and flap repair

DOI： 10.1067/moe.2000.107355

リポジトリ公開URL： https://hdl.handle.net/2324/7218261

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Abnormal blood flow to the submandibular glands of patients with Sjogren's syndrome

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Clinical evaluation of "veraviewpocs" digital panoramic X-ray system

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Doppler spectral waveform analysis of arteries of the hand in patients with Raynaud's phenomenon as compared with healthy subjects

リポジトリ公開URL： https://hdl.handle.net/2324/7218260

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Prediction of perceptibility curves of direct digital intraoral radiographic systems

DOI： 10.1038/sj.dmfr.4600450

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Assessment of image quality in dental radiography, part 2: optimum exposure conditions for detection of small mass changes in 6 intraoral radiography systems

DOI： 10.1016/S1079-2104(99)70305-7

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Imaging findings of lipomas in the orofacial region with CT ,US and MRI.

DOI： 10.1016/S1079-2104(97)90302-4

リポジトリ公開URL： https://hdl.handle.net/2324/7218258

開催年月日： 2022年6月

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：福岡市   国名：日本国  

MRI診断といえば、T1強調像やT2強調像などの画像を視覚的に定性的に評価する事が通常の診療である。しかし、縦緩和時間(T1)や横緩和時間(T2)、プロトン密度、拡散係数などの情報は、病変の生理的・生化学的な情報を含み、病態に特有な事も多い。本講演では、組織固有のパラメータの測定法を提示し、定量化が画像の解釈にもたらす有用性を自経例や他施設の論文をもとに紹介する予定である。紹介する主な項目を以下に示す。 T1の利用として、ダイナミック撮影について取り上げる。造影剤投与前後の信号強度の変化をパターン分類する事が一般的である。しかし、造影前・造影中のT1を算出すれば、各時相における造影剤濃度に変換でき、さらに薬物動体解析が可能となる。標準化モデルを利用すれば、造影剤の血漿から血管外細胞外腔(EES)への移行定数(Ktrans)、EESの割合(ve)、血漿の割合(vp)が算出できる。我々も顔面部の鑑別診断において、悪性腫瘍は良性腫瘍よりKtransが大きく、veが小さい事、悪性腫瘍の中では、veは悪性リンパ腫<扁平上皮癌<腺系悪性腫瘍である事を示した(Kitamoto E, Acad Radiol 2015)。口腔扁平上皮癌の術前化学放射線治療の組織学的治療効果判定では、照射後のveの増加、Ktransの増加は良好な治療効果を示した。腫瘍細胞の消失、血流増加による低酸素状態の改善が良好な治療効果を示すと考えられた（Chikui T, J Magn Reson Imaging 2012）。 T2 に関しては、顎関節円板に関して取り上げる。顎関節症では、円板位置、joint effusionの有無、下顎頭の骨変化の有無など代表的な評価項目である。円板のT2は、病態がすすむと増加傾向にあり、上記の診断項目と関係するという報告が見られる。病変の進行により、膠原繊維の基質であるグリコサミノグリカンの含有量の低下と関係すると考えられている。 プロトン密度に関しては、脂肪含有率に関して取り上げる。現在、DIXON法が、脂肪・水分離の手法として広く臨床応用されている。T2*減衰の補正、複数の化学基による多ピークを考慮した6 point DIXON法は、正確な脂肪含有率の算出のため肝臓の撮像法として開発された。最適化により唾液腺においても正確な脂肪含有率を得る事が可能であった。耳下腺は、正常な成人でも体重やBMIにより高い脂肪含有量を示す事はあるが、顎下腺では一般的に低値であった。一方、唾液量の低下を示す代表的疾患であるシェーグレン症候群では、顎下腺においても急速に脂肪沈着がすすむ事を定量的に示す事ができた（Chikui T, Br J Radiol 2017）。 拡散強調像に関しては、monoexponential モデル, IVIM モデル, gamma分布モデルなどを提示し、診断での応用を呈示する予定である。

開催年月日： 2022年6月

記述言語：英語  

開催地：On line   国名：日本国  

Objectives To evaluate whether dual-energy CT (DECT) imaging analysis are useful for the detection of lymph node metastases in oral squamous cell carcinoma. Methods In this study, 23 new oral squamous cell carcinoma patients who underwent contrast-enhanced CT were included. 64 lymph nodes (20 metastatic, 44 nonmetastatic) pathologically diagnosed by neck dissection were retrospectively evaluated. A circular regions of interest (ROI) was drawn on the largest diameter of the control lymph node, specifically avoiding areas of visible necrosis. From these ROIs, attenuation values at 40 keV, 70 keV, and 100 keV, and iodine concentration data were recorded. The spectral attenuation curve slope (40 keV-70 keV, 40 keV-100 keV) and iodine concentration were used as three parameters to correlate with pathology. Results The spectral attenuation curve slope was significantly lower in metastatic nodes than in nonmetastatic nodes. Iodine concentration was significantly lower in metastatic nodes than in nonmetastatic nodes. There was an extremely high correlation between the spectral attenuation curve slope and iodine concentration. Conclusions Both spectral attenuation curve slope analysis and iodine concentration are expected to improve detection of lymph node metastasis in oral cancer. Furthermore, it was suggested that iodine concentration could be used as a single representative parameter.

開催年月日： 2022年6月

記述言語：英語  

開催地：On line   国名：日本国  

Objectives: To evaluate the correlation between the parameters derived from TSE-diffusion weighted imaging (TSE-DWI) and those obtained by a pharmacokinetic analysis based on dynamic contrast enhanced MR imaging (DCE-MRI). Methods: A total of 33 orofacial lesions were included. Patients underwent both TSE-DWI with 6 b-values and DCE-MRI with a temporal resolution of 1.97s. From TSE-DWI, we estimated the true diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f) using an IVIM model, and the apparent diffusion coefficient (ADC) using an monoexponential model. From DCE-MRI, we estimated the influx forward volume transfer constant (Ktrans), fraction volume of cellular space (vc), extracellular-extravascular space (ve) and plasma (vp). Location-matched regions of the interest were placed when possible. Spearman’s correlation coefficients were estimated between the parameters. Results: Vc had moderate or weak negative correlations with D and ADC (ρ=–0.413 and ρ=–0.349, respectively), while ve had a moderate or weak positive correlation with D and ADC (ρ=0.409 and ρ=0.371 respectively). Both trends were reasonable; however, the comparative low correlation coefficient may be related to other factors that affected the diffusion-parameters and the uncertainty of both the diffusion and pharmacokinetic models. Vp had a weak positive correlation with f (ρ=0.388). The moderately positive correlation with Ktrans(ρ=0.443)) was slightly surprizing, because Ktrans is determined by both blood flow and the permeability surface-area product. Conclusions: Although DCE-parameters could be predicted from diffusion-derived parameters to some extent, both parameters should be used in a complementary way.

開催年月日： 2022年6月

記述言語：英語  

開催地：On line   国名：日本国  

Objectives: To compare the delineation of mandibular cancer by 3D T1 turbo field echo with Compressed SENSE (CS-3D-T1TFE) images and MDCT images and compare them with histopathological images as reference standards to validate the accuracy and clinical usefulness of CS-3D-T1TFE reconstruction images. Methods: Twenty-four patients with mandibular squamous cell carcinoma (SCC) who underwent MRI including CS-3D-T1TFE and MDCT examination before surgery were included. For both images, 0.5-mm-thick coronal plane images and 0.5-mm-thick plane images perpendicular and parallel to the dentition were constructed. Two radiologists rated bone invasion in three type categories indexed by cortical bone, trabecular bone, and mandibular canal, and inter-rater agreement was assessed by weighted kappa statistics. In 20 of 24 cases, the bone invasion was correlated with histopathological evaluation by pathologists using Pearson's correlation coefficient. Soft-tissue invasion was assessed by diagnosing the presence of invasion into mylohyoid muscle, gingivobuccal fold, and masticator space, and inter-rater agreement was assessed by kappa statistics. Results: In the evaluation of bone invasion, the inter-rater agreement in the imaging evaluation of CS-3D-T1TFE was higher than that of MDCT and showed a high correlation with pathological assessment. In the soft-tissue invasion assessment, CS-3D-T1TFE showed higher inter-rater agreement than MDCT on all measures of soft tissue invasion. Conclusions: CS-3D-T1TFE reconstructed images were shown to be clinically useful, accurately depicting the extent of mandibular cancer invasion and potentially solving the problem of conventional MRI overestimating the lesion.

開催年月日： 2021年5月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：On line   国名：日本国  

開催年月日： 2020年7月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：On line   国名：オーストラリア連邦  

開催年月日： 2019年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：熊本   国名：日本国  

本文 【目的】ガンマ分布モデル(GD model)法および簡易IVIM法を顔面部腫瘍の拡散強調画像に応用し有用性を検討する事。 【方法】 対象は、Philips社製1.5T装置にてEPI型拡散強調画像 b値(0,500,1000,1500s/mm2)を撮像された症例。悪性76例（悪性リンパ腫：14, 扁平上皮癌：54, 悪性唾液腺腫瘍：7, その他：1）、良性27例（多形腺腫：6, 脈管系腫瘍：14, その他：7）である。gamma distribution (GD) model法では、shape parameter（κ）およびscale parameter(θ)を算出し、拡散係数をD<1.0x10-3mm2/s (f1), 1.0x10-3mm2/s<D<3.0x10-3mm2/s (f2), D>3.0 x10-3mm2/s (f3)と区分し、細胞内拡散・細胞外拡散・灌流成分を反映すると想定した。簡易IVIM法では、 b値 0,500,1000 s/mm2より、D (true diffusion coefficient), f (perfusion fraction)を算出し、GD model法のパラメーターとの相関を検討した。 【結果】 悪性腫瘍は、良性腫瘍に比較し、有意に小さなκを持ち、f1は有意に大きく、 f2は、有意に小さかった。f1は、悪性リンパ腫, 扁平上皮癌, 悪性唾液腺腫瘍, 多形腺腫、脈管系腫瘍の順に減少し、特徴的であった。f3は、MLが小さく、脈管系腫瘍で大きかった。GD model法で得られたf1は、簡易IVIM法で得られたDと強い負の相関を認め、f3とfには強い正の相関を認めた。 【結論】 GD model法は、良悪性鑑別に有用であり、パラメーターは各病変の特徴を反映すると考えられた。またGD model法の結果は、簡易IVIM法の結果と比較しても妥当であると考えられた。

開催年月日： 2018年5月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

Purposes The first was to compare the distortion ratio (DR) and the signal-to-noise ratio (SNR) between TSE-DWI and EPI-DWI. The second was to demonstrate the image distortion between TSE-DWI and T2 WI and to estimate ADC in various kinds of diseases. Materials & Methods At first, 42 patients underwent MRI using TSE-DWI and EPI-DWI. The DR, SNR, and ADC were compared between the two techniques. Secondly, 160 underwent MRI using TSE-DWI. The distortion along X- and Y-axes was defined the distance from the centroids of the lesion on DWIb1000 to that of T2WI. We also estimated ADC values of the lesions. Results DR of TSE-DWI was significantly less than that of EPI-DWI and SNR of TSE-DWI was significantly higher than that of EPI-DW. ADC values of palatine tonsils and submandibular glands in TSE-DWI were significantly higher than those in EPI-DW. The deviations along X-axis were 0.57±1.30 mm and that along the Y-axis were 0.27±1.74 mm, therefore, the image distortion was very small. Regarding the ADC values, cysts presented the highest values followed by vascular lesion and benign tumors, while malignant lymphoma showed the lowest values. Conclusions TSE DWI can produce less distortion and higher SNR than TSE-DWI, while TSE-DWI possibly exhibits different ADC values. Therefore, the TSE-DWI could be good alternative to EPI-DWI and is useful for the differential diagnosis.

開催年月日： 2017年9月

記述言語：英語  

開催地：Las Vegas   国名：アメリカ合衆国  

Purpose Many studies have supported the utility of diffusion-weighted images (DWIs) in the differential diagnosis. However, Echo-planar imaging (EPI) DWIs are susceptible to inhomogeneity of the magnetic field, which limits their usefulness in the head and neck region. Thus, the first purpose of this study was to evaluate the image distortion of Turbo-spin echo (TSE)-DWIs in comparison to anatomical images. The second purpose was to demonstrate the apparent diffusion coefficient (ADC) values in various types of head and neck lesions. Materials & Methods In all cases, MRI was performed using a clinical 3T whole-body MRI system (Philips Healthcare, Best, Netherlands). A total of 99 cases were enrolled. In each case, MRI was performed and T2-weighted images (T2WIs) and TSE-DWIs (b-value, 0 and 1000 s/mm2 [DWIb0 and DWIb1000]) were obtained. At first, the DWI was reoriented onto a T2WI to match the matrix size and slice thickness. Then, we carefully drew the lesion, the bilateral Masseter muscles (MMs) and the spinal cord and defined them as regions of interest (ROIs) on a DWIb0, a DWIb1000 and a T2WI. The centroids of the ROIs were obtained. The differences along the X-axis (the direction of frequency encoding) and the Y-axis (the direction of phase encoding) were measured among these centroids. For the second purpose, an ADC map was obtained using DWIb0 and DWIb1000 images. All of the procedures were performed using the OsiriX Lite software program (Pixmeo SARL, Bernex, Switzerland) and the Image J software program (NIH, Maryland, USA). Results The 88 cases (89%) (benign tumor, n=20; malignant tumor, n=52; inflammation, n=9; cyst, n=7) could be evaluated by TSE-DWI .Eleven cases were excluded because their lesions were too small (n=8), or due to the presence of a severe metal artifact (n=3). Focusing on the comparison of DWIb1000 images to T2WIs, the deviations along X-axis were 0.87±0.62 mm, 0.74±0.61 mm, and 0.42±0.38 mm (lesion, MMs, and spinal cord, respectively). Meanwhile, the deviations along the Y-axis were 1.37±1.28 mm, 1.44±0.99 mm, and 0.67±0.57 mm (lesion, MMs, and spinal cord, respectively). The deviation along the Y-axis was significantly larger than that along the X-axis in MMs and the spinal cord (p-value < 0.05); however, the absolute amount was not so large. In addition, the deviation that was observed between DWIb0 images and T2WIs was almost identical to that observed between DWIb1000 and T2WI (mean difference, <0.1 mm). Thus, the image distortion in the direction was not so severe. Regarding the ADC values, cysts presented the highest values (1.91±0.59 x10-3 mm2/s) followed by benign tumors (1.46±0.44 x10-3 mm2/s), while malignant lymphoma showed the lowest values (0.86±0.12 x10-3 mm2/s). Thus, the ADC values obtained from TSE-DWIs were useful for evaluating these lesions. Conclusions TSE-DWIs were found to be immune to image distortion; thus, these images could be easily superimposed on anatomical images. Moreover, the ADC values that were obtained showed high diagnostic power in assessment of head and neck lesions.

開催年月日： 2017年9月

記述言語：英語  

開催地：Las Vegas   国名：アメリカ合衆国  

Objective Many studies have supported the utility of diffusion-weighted image (DWI) for detecting recurrence. However, Echo-planar imaging DWIs are susceptible to inhomogeneity of the magnetic field, which limits its usefulness in the head and neck region. The first objective was to evaluate the utility of turbo spin echo (TSE)-DWI for detecting recurrence of oral cancer. The second objective was to compare the observer performance between TSE-DWI and gadolinium-enhanced T1-weighted imaging (Gd-T1WI). Materials and Methods Forty-two patients underwent surgery for oral squamous cell carcinoma and postoperative MRI, including axial T2-weighted imaging (T2WI), TSE-DWI and Gd-T1WI. All MRI procedures were performed using a 3T MRI system (Philips Healthcare, Best, the Netherlands). Twenty-two patients were classified as the recurrence group, and 20 were classified as the non-recurrence group. First, the DWI images were automatically adjusted for the translational and rotational motion to achieve superimposition with the Gd-T1WI images. We then assumed the high-signal-intensity area on DWIb1000 images or the enhanced area on Gd-T1WI images to indicate signs of recurrence and calculated the sensitivity and specificity. Once the enhanced area was identified, we outlined this area as a region of interest, copied it onto the adjusted ADC map, and measured the ADC value. These procedures were performed using the PACS system (Volume Analyzer Synapse Vincent; FUJIFILM, Tokyo, Japan). Next, two observers (observer 1: 22 years experience, observer 2: 3 years experience) interpreted the presence of recurrence using a five-point scale. The first session included the T1WI, T2WI and Gd-T1WI images, and the second included the axial T1WI, T2WI, DWIb1000, ADC map and combined T2WI and DWIb1000 fusion images. We estimated the area under the curve (AUC) using a receiver operating characteristic analysis. The image interpretation was performed on a personal computer using the OsiriX Lite software (Pixmeo SARL, Bernex, Switzerland). Results The sensitivity was 81.8% on both DWI b1000 and Gd-T1WI, and the specificity was 75% on DWI b1000 and 55% on Gd-T1WI. Although the specificity of DWI b1000 was quite high, the T2 shine-through might have reduced it to some degree. Of the 27 cases with enhanced areas on Gd-T1WI, the ADC of non-recurrence (1.82±0.51×10−3 mm2/s) was significantly higher than that of recurrence (1.14±0.113×10−3 mm2/s) (P<0.0001, Wilcoxon’s test). The AUCs in the first session including Gd-T1WI were 0.74±0.08 and 0.66±0.08 for observers 1 and 2, respectively. The AUCs in the second session including DWI were 0.79±0.07 and 0.82±0.06 for observers 1 and 2, respectively. There was a significant difference in the findings of observer 2 between the two methods (P=0.02). Therefore, DWI yielded a higher AUC, even if they did not used the enhanced MR images. In addition, a low ADC value was found to be characteristic of recurrence, and a good fusion image on DWI along with anatomical images were believed to help observers interpret the imaging findings. Conclusions TSE-DWI was found to be immune to image distortion and proved useful for differentiating between recurrence and a postoperative state. Adding the TSE-DWI sequence improved the observer performance regarding the interpretation of recurrence.

開催年月日： 2017年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：かごしま県民交流センター 鹿児島市山下町14番50号   国名：日本国  

開催年月日： 2016年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Chiang Mai   国名：タイ王国  

開催年月日： 2016年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Chiang Mai   国名：タイ王国  

開催年月日： 2016年9月

記述言語：英語  

国名：アメリカ合衆国  

Purpose The first purpose was to assess the value of a six-echo variant of the modified Dixon Quant (mDixon) for salivary gland fat fraction (FF) quantification against multi-echo T2 corrected MR spectroscopy which was used as the reference standard. The second goal was to apply mDixon to estimate the FFs and to compare them among the control group, Sjogren's syndrome (SS) group and IgG4 related disease (IgG4-RD) group. Materials and Methods To conduct this study, 10 healthy volunteers were enrolled and 20 parotid glands (PGs) were evaluated. Quantitative MRI was performed using the mDixon sequence in addition to single-voxel MRS to compare the mDixon-FF with MRS-FF. On the FF image obtained by the mDixon method, we measured the FF of the region of interest (ROI). For the MRS, five unsuppressed 1H spectra were acquired by the Stimulated Echo Acquisition Mode with different echo delays (TE=13-53ms). Time-domain quantification was performed using the AMARES algorithm from the MRUI software package. Relaxation times T2 of water and the four main different triacylglycerol components (5.3, 2.1,1.3,and 0.9 ppm) were determined. For the second purpose, we applied the mDixon sequence to 64 cases. Eleven patients were thus assigned to the SS group, 4 patients to the IgG4-RD group, and the remaining 49 patients to the control group with any abnormality of the salivary gland. The outlines of both the PGs and submandibular glands (SMGs) were traced to set the ROIs to estimate the FF. In the control group, we evaluated any correlations among the FF, height, weight, body mass index (BMI), cholesterol level, and serum triglyceride level. We also compared the FF among the three groups. Results The FF(mDixon) correlated closely with the FF(MRS) according to the following equation FF(mDixon)=1.06xFF(MRS)-2.6 with R2 of 0.99. Therefore, the FF(mDixon) was considered to be potentially appropriate for clinical use. The PG-FF of the control group positively correlated with the weight and BMI (?=0.32, P=0.024 and ?=0.59, P < 0.001, respectively). The SMG-FF also correlated with the weight, BMI and serum triglyceride levels (?=0.59,P=0.0228, ?=0.38,P=0.0067 and ?=0.52, 0.0004, respectively). The SS group had a higher PG-FF(50.3±1.7%) than both the control group (34.9±11.1%) and IgG4-RD group (35.2±21.7%) and a significant difference was found between the SS group and control group (P=0.0113, Steel-Dwass test). This trend was remarkable in the submandibular gland. The SS group had a significantly higher SMG-FF(41.1±25.9%) than both the control group (7.4±4.5%) and IgG4-RD group (3.9±3.2%) (P < 0.0001 and P=0.0258, respectively, Steel-Dwass test). Therefore, the SMG-FF was lower than the PG-FF in the control group (P < 0.001, paired t test), however fat may accumulate rapidly in SMG patients due to the progression of SS. Conclusions Estimating the FF of the salivary gland using mDixon was thus found to be highly accurate in comparison to the MRS method. Therefore, this modality is considered to be potentially appropriate for clinical application. The FF obtained by mDixon quantitatively revealed the characteristic fat accumulation (especially SMGs) in the SS group.

開催年月日： 2016年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

健常ボランティアの耳下腺の脂肪含有率 (FF)を、MR spectroscopy（MRS）を用いて算出しmDIXON Quantを用いてFFを測定し、両者を比較した。 MRSでは、0.9, 1.3, 2.1, 5,2 ppmの4つのpeakが全対象において同定可能であった。1.3ppm peak (methylene基)が最大であり、全脂肪peakの60％をしめ、肝臓で報告されている値とほぼ同じ値であった。MRSから得られたFFとmDIXON QuantのFFは高い相関を認めた。

開催年月日： 2015年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

目的　 第一にmDIXON Quantを用い、正常群の耳下腺および顎下腺の脂肪含有率 (FF)およびT2*を求め、年齢,身長,体重, BMI,血清コレステロール,中性脂肪との相関を検討する事。第二に正常群とシェーグレン症候群(SJS)群においてFF, T2*を比較する事。 方法　 対象は、唾液腺に病変のない正常群43名、SJS症例11名。撮像法は、6 point Dixon法であるmDIXON Quantを用いた。両側耳下腺、顎下腺に関心領域（ROI）を設定し、FFおよびT2*を算出した。統計はピアソンの相関係数、Wilcoxonの検定を用いた。 結果 1. 正常群において、耳下腺FFは、顎下腺FFに比較し有意に大きかった。BMIは、耳下腺・顎下腺FFともに有意に正の相関を認めた。中性脂肪は、顎下腺FFと正の相関を認めた。 2. SJS群の顎下腺FFは、正常群に比較し有意に大きかった（P=0.0003）。正常群の顎下腺FFは低いが、SJS症例では急速に全体的に脂肪沈着が進むためと考えられた。耳下腺では、SJS群が大きい傾向であったが有意差は認めなかった（P=0.070）。しかし、FFの標準偏差は、SJS群が正常群より有意に大きかった(P=0.0002)。耳下腺のFFは、正常群でもBMIの影響を受けるため、平均値では有意差を認めないが、腺破壊・脂肪沈着が局在的に進むため、標準偏差には有意差が生じたと考えられた。 まとめ　 顎下腺FFは、耳下腺FFより低いものの、いずれもBMIの影響が大きい事が明らかになった。SJS群と正常群との判別には、顎下腺ではFFの平均値、耳下腺ではFFの標準偏差が有効である事が示唆された。

開催年月日： 2015年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：仙台市   国名：日本国  

目的 健常ボランティアの耳下腺および顎下腺の脂肪含有率 (FF)をmDIXON QuantおよびMR spectroscopy (MRS)の2種類の方法で測定し、両者の相関を求めの強さ、mDIXON Quantがの臨床に使用できるか否か的有用性についてを検討する事。 方法 対象は、健常ボランティア15名を対象とした。使用した装置は、フィリップス社製 Ingenia 3.0Tである。６point Dixon法であるmDIXON QuantとMRSとしてPRESS法(Single TE)での撮像を行った。10名については、T2時間の影響を考慮する為 PRESS (Multi TE)での撮像も行った。mDIXON Quantでは、得られたFF mapより両側耳下腺、顎下腺に関心領域を設定し、FFを求めた。 結果 1. mDIXON QuantとPRESS Single TEにて測定したFFに関して、両者に非常に高い相関が認められた（slope=1.05　R2=0.957）。 2. PRESS (Multi TE)によるり脂肪peakのT2値は、水peakのT2値より大きかった。 3. Multi TE法によりT2時間の影響を考慮した場合においても、mDIXON QuantとPRESSで求めたFFとの間に高い相関を認めた（slope=0.61　R2=0.975）。 まとめ mDIXON Quantで求めた耳下腺・顎下腺のFFは、PRESSで求めたFFと非常に高い相関を示し、臨床的有用性が高いと思われた

開催年月日： 2015年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：仙台   国名：日本国  

目的 口腔扁平上皮癌症例において、薬物動態解析により得られたバラメーターと原発部位,分化度, TNM分類との相関を検討する事。 方法 対象は85名の扁平上皮癌患者。使用した装置は、フィリップス社製 Achieva 1.5T Nova Dual。DCE-MRIは、3D-T1FFEにて撮像し、3.5s毎,80相を撮像した。DataをTK model 解析し、原発巣のAUGC, Ktrans, ve, vpを算出した。T1 map作成はdual flip angle法を用い、動脈入力関数はmodel AIFを使用した。TNM分類には、視診触診,CT, MRI, USおよびPET-CTを用いた。 結果 1. いずれのパラメーターも原発部位, 分化度, T stageによる有意差は認めなかった。 2. N stageの進行した症例では、AUGCおよびKtransが減少する傾向がみられ、AUGCではN0群とN2+3群、KtransではN0群とN2+3群およびN1群とN2+3群に有意差を認めた。 考察およびまとめ N stageの進行した症例では、AUGCおよびKtransが減少する傾向がみられ、血流減少による低酸素状態がリンパ節転移に関与する可能性が示唆された。 略語 AUGC: 造影剤濃度の積分値 Ktrans:造影剤の血漿から血管外細胞外腔への移行定数 ve :血管外細胞外腔の占める割合 vp :血漿の占める割合

開催年月日： 2015年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：仙台市   国名：日本国  

mDIXON Quantによる唾液腺脂肪含有率の検討 筑井徹1、木瀬祥貴1、山下 泰生2、小林 幸次2、武村 濃3、吉浦　一紀1 1. 九州大学大学院歯学研究院口腔画像情報科学分野 2. 九州大学病院医療技術部放射線部門 3. フィリップスエレクトロニクスジャパン 目的 第一に健常者の耳下腺および顎下腺の脂肪含有率 (FF)を求め、身長,体重, BMI, 血清コレステロール, 中性脂肪との相関を検討する事。第二に健常者群とシェーグレン症候群(SS)群においてFFを比較する事。 方法 対象は、健常者35名、SS症例8名。使用した装置は、フィリップス社製 Ingenia 3.0Tである。撮像法は、６point Dixon法であるmDIXON Quantを用いた。得られたFF mapより両側耳下腺、顎下腺に関心領域を設定し、耳下腺FF、顎下腺FFとした。 結果 1. 健常者の耳下腺のFFは、37±11%であり、体重,BM,中性脂肪の増加に従い増加する傾向にあったが、有為な相関は認めなかった。 2. 健常者の顎下腺のFFは、8.5±4.7%であり、体重, BMI,中性脂肪とは正の相関を認めた。 3. SS群のFFは、耳下腺においては、健常者に比較し大きな傾向にあったが、有意差は認めなかった。一方、SS群の顎下腺FFは、41±29%であり、健常者群8.5±4.7%に比較し、有意差を認めた(P=0.02, Wilcoxon/Kruskal-Wallis test)。 まとめ 　顎下腺のFFは、体重、BMIおよび中性脂肪値と正の相関を示すが、SS群のFFは、それらの生理的な変動に考慮しても、正常群より大きかった。顎下腺FFはSSの診断に有用である事が示唆された。

開催年月日： 2014年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Bali - Indonesia   国名：インドネシア共和国  

Institution and Country Department of Oral & Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Japan. *Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Japan. Correspondence e-mail okamura@rad.dent.kyushu-u.ac.jp Introduction Iterative Reconstruction (IR) algorithms for Computed Tomography (CT) is widely used in clinical practice in late years. Although improvement in image quality and dose reduction have been reported, many were evaluated based on soft tissue. Objectives To evaluate improvement effect on the IR method in hard tissue like teeth and bone, with high-contrast object. Materials and methods Images of a high-contrast and a water cylinder phantom were acquired with Alexion four-row CT (Toshiba Medical Systems, Tokyo, Japan) at 120 kV tube voltage and five tube current levels. They were reconstructed with filtered back projection (FBP) and adaptive iterative dose reduction three-dimensional (AIDR 3D; Toshiba Medical Systems) reconstruction algorithms using the bone kernel. The slice thickness was 1.0mm and the reconstruction FOV was 70.2mm. The minimum separable hole size was estimated on the images of the high contrast phantom and the noise power spectrum (NPS) was measured on the images of the water cylinder phantom for FBP and for four levels of AIDR 3D. Results The NPSs of AIDR 3D were lower than that of FBP. The noise reduction effect was observed visually at low tube current. The minimum separable hole size was 0.5mm at 150 and 100mA, it raised by lowering tube current, and it was 1.0mm at 10mA. There ware no effect of AIDR 3D in detection size. Conclusions and discussion On these conditions, the effect of AIDR 3D did not lead to improvement in detection ability. At the time of evaluation of the hard tissue with low tube current, use of AIDR 3D may have an opposite effect. Evaluation with complicated structures like trabecular bone is required.

開催年月日： 2014年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Bali - Indonesia   国名：インドネシア共和国  

Introduction Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely performed, but cannot elucidate the underlying physiological conditions. A pharmacokinetic analysis of the DCE-MRI findings may provide such information. Objectives: To elucidate the characteristics of tumors using a pharmacokinetic analysis. Materials and Methods A total of 135 tumors were examined［91 squamous cell carcinomas (SCC), 24 malignant lymphomas (ML), 10 malignant salivary gland tumors (MSGTs) and 10 pleomorphic adenomas (Pleo)］. We applied the Tofts and Kermode model and obtained three parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (Ktrans), the fractional volume of EES (ve) and the fractional volume of plasma (vp). We compared the parameters among the four types of tumors and also evaluated the correlation between the TMN stage and the parameters in SCC. Results ML had a significantly lower ve than the other categories (SCC; P<0.0001, MSGT; P=0.049 and Pleo; P=0.0001) and it also had the lowest Ktrans. Pleo had the highest ve value, significantly higher than that of SCC (P=0.0033), and had the lowest vp, which was significantly different from SCC (P=0.018). A small amount of EES and low permeability were characteristic of ML, while a large amount of EES and poor vascularity were characteristic of Pleo. In SCC, the Ktrans decreased with the progression of the N stage, and the Ktrans of N2 cases was lower to that of No cases (P = 0.0028). Conclusions The pharmacokinetic analysis clarified the physiological conditions of the tumors.

開催年月日： 2014年11月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Bali - Indonesia   国名：インドネシア共和国  

Introduction Malignant lymphoma（ML）almost occurs in lymph node, but rare extranodal. It was frequently mistaken for another malignant tumor. Objectives To elucidate the characteristics of ML imaging features in head and neck region. Materials and methods We described 8 patients (5 male and 3 female, average age, 67 years, age range 20). 8 lesions were histopathologically diagnosed as ML (tongue, 1 buccal mucosa, 3 maxilla and palate, 3 submandibular, 1) between 2006 and 2012. MRI was performed all lesions. We evaluated the signal intensity (SI) of T1WI, T2WI and estimated the diffusion coefficient (ADC) with b-factors of 0,500,1000 sec/mm2. In four cased, the dynamic MRI study was performed and the time intensity curve (TIC) was obtained. US was performed 2 lesions. US end point was internal echogenicity, internal vascularity, posterior echo enhancement. Results All ML cases had low intensity on T1WI. On T2WI, SI ranged from middle to high intensity. Mean ADC values were 0.771±0.142 sec/mm2 for ML, which were significantly lower than squamous cell carcinoma (? ± ??sec/mm2 in our preliminary study). TIC type showed a rapid increase downward titration type or a rapid increase storm decrease type. Conclusions and discussion　 On both T1WI and T2WI, SI was not specific for ML.　However, ADC was extremely low and the most characteristic finding, which suggested the small amount of extracellular space.

開催年月日： 2013年9月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

位相画像を用いたAIF算出を試み、コンパートメントモデル解析に与える影響を検討した。個人差を反映するAIF算出としてphase情報は、有用性が示唆されるものの、dynamic撮像中に蓄積するエラーにより、平衡相のAIFに変動をあたえ、血管外細胞外腔（ve）が不正確になるケースが見られた。

開催年月日： 2013年9月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

放射線照射による急性期耳下腺障害をDCE-MRIの薬物動態解析, ADC mapおよび体積変化により評価した。mean doseが増えるとKtrans、ve、ADCは増加し、その変化は、比較的低線量でも確認された。 Ktransの増加は照射による血流増大、血管透過性の亢進を反映し、veの増加は腺細胞の消失によるEESの増大を反映していると考えられた。

開催年月日： 2013年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2013年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2012年9月

開催地：Leipzig   国名：ドイツ連邦共和国  

OBJECTIVE The individual arterial input function (AIF) is preferable for accurate pharmacokinetic analyses, even if the estimation of the individual AIF in the neck is challenging. The purpose of this study is to apply phase information when estimating the AIF for pharmacokinetic analysis. Materials and methods Thirteen patients underwent dynamic DCE-MRI. The scan included 3D-T1 FFE sequences with a temporal resolution of 3.5 s. Both magnitude and phase-shift images were reconstructed. the concentration of contrast medium (CM) in tissue (Ct (t)) was estimated using the magnitude image. The phase image was used to estimate the concentration of CM in artery (Ca (t)). The average Δφwas converted to Ca(t) using the equation: Δφ　=　TE　・ π　・γ　・B0 ・　χm ・ΔCa・ (cos2θ-1/3) where γ is the proton gyromagnetic ratio, B0 is the magnitude of the main magnetic field in Tesla, χm is the molar susceptibility of the CM, and θ is the angle of the vessel relative to the main magnetic field. The concentration of CM in plasma (Cp (t)) was defined as; Cp (t) = Ca /(1-Hematocrit). A single observer, aware of the primary tumor site, placed a ROI on the ipsilateral ICA for the estimation of the AIF. Next, the observer placed it on the contraleral ICA. The peak concentration (Ca peak), the average of the concentration (Ca avg), and the concentration during last 30 phases (Ca last 30) were compared between the ipsilateral and contraleral ICA. Secondly, the pharmacokinetic analysis in TK model was applied to each voxel, where Ktrans is influx forward volume transfer constant, ve is fractional volume of EES and vp is the fractional volume of plasma. Quantitative measurements derived from the ipsilateral ICA reference curves were compared with similar measurements derived from a contralateral reference. Results. The AIF could be estimated on both sides in 11 out of 13 patients . The AIF could not be obtained in one patient due to severe body motion. The contralateral AIF was observed to fluctuate in another patient during the equilibrium phase. 　There was a high correlation between the ipsilateral ICA and the contraleral ICA in both the Capeak and Caavg (Ca peak, slope = 0.95,r = 0.79;and Ca avg, slope = 0.97, r = 0.65). The Ca last 30 had a somewhat lower correlation than either Ca peak or Ca avg. (Ca last30, slope = 0.97,r = 0.49), which may have been affected by the body motion and the lower SN ratio. 　None of the pharmacokinetic parameters were significantly different, whether the AIF ROI was on the ipsilateral ICA or the contralateral ICA. There was a high correlation in all parameters (Ktrans, slope = 0.94,r = 0.79; ve, slope = 0.96, r = 0.86; and vp, slope = 0.90, r = 0.70). CONCLUSION. Ktrans shows good absolute agreement (high correlation coefficient, slope≒1.0) between AIFipsi and AIFcontra. The phase images are thus found to be potentially useful for estimating the AIF and making Ktrans map in the maxillofacial region. However, there is a week agreement on Ve due to the inaccurate estimation of the AIF during late phases. Therefore, the population-averaged AIF might be preferable for the estimation of Ve.

開催年月日： 2012年9月

国名：ドイツ連邦共和国  

OBJECTIVES: This study was designed to elucidate the characteristics of a primary tumor in the maxillofacial region using pharmacokinetic analyses based on the TK model. MATERIALS AND METHODS: Dynamic contrast enhanced MRI (DCE-MRI) was performed for 54 patients (35 squamous cell carcinoma, 10 malignant lymphoma, 4 malignant gland tumor,5 pleomorphic adenoma). The axial DCE scan consisted of a 10 slice, 3D-T1 fast-field echo sequence. A T10 map was estimated by the dual flip angle method (5° and 15°) and the signal intensity of tissue was converted into the concentration of the contrast medium in tissue. The area under　the gadolinium concentration curve (AUGC) was calculated after injection. The data were analyzed using a TK model. The influx forward volume transfer constant into EES from plasm (Ktrans), fractional volume of the extravascular extracellular space (ve), and fractional volume of the plasma (vp) were estimated. This study used a predefined model arterial input function. The MR image data (Philips PAR/REC format) were transferred to a personal computer from the MRI operating console and processed using a proprietary software program (PRIDE software, Philips Healthcare, Eindhoven, The Netherlands) using the RSI interface data language (IDL). Tukey' s HSD test was used to compare the parameters among the four categories. RESULTS: ML had the lowest AUGC among the four categories and there was a significant difference between ML and SCC (P<0.05). The malignant tumors had a higher Ktrans than the pleomorphic adenoma, which might reflect the fact that the angiogenesis factors from the malignant tumor caused the higher permeability.

開催年月日： 2012年9月

会議種別：口頭発表（一般）  

開催地：京都   国名：日本国  

目的 口腔扁平上皮癌患者の術前化学放射線治療前後においてADC値や、dynamic contrast MRI(DCE-MRI)の定量解析により得られる指標が、組織学的抗腫瘍効果判定を反映するか検討する。 方法 口腔扁平上皮癌患者で、術前治療前および術前治療後に拡散強調像およびDCE MRIを撮像した37症例を対象とした。術前治療は、外照射30GyおよびTS-1を基準とした。拡散強調画像では、b factorを0,500,1000, 1500s/mm2とし、ADCを算出した。DCE-MRIでは、3.5秒毎80フェーズを収得し、画像データを2コンパートメントモデル解析した（Philips社製　PRIDE）。術前治療の組織学的抗腫瘍効果は、手術後の摘出標本を対象に、大星・下里の分類を用いて判定した。解析では、Grade ⅠおよびⅡaをnon-responder群、Ⅱb、Ⅲ、Ⅳ群をresponder群とした。 結果 治療前後とも評価できたのは、コンパートメントモデル解析では、35/37症例であったが、ADCの評価は、21/37症例のみであった。 治療前のパラメータでは、いずれも両群間に有意差を認めなかった。治療後では、responder群のADC［(1.37±0.05)x10-3mm2/s］は、non-responder群［(1.17±0.07)x10-3mm2/s］より有意に大きかった(P=0.04)。コンパートメントモデル解析でえられる血管外細胞外腔の割合(ve)もresponder群(0.394±0.016)は、non-responder群(0.288±0.023)に比較し有意に大きかった(P=0.01)。 考察 responder群では、治療により癌胞巣の破壊による細胞間質の増加の割合が大きく、その事が、ADCの増加、veの増加に反映されたと考えられた。顎顔面領域では、拡散強調像のアーチファクトを考慮するとDCE-MRIのコンパートメントモデル解析が有利であると考えられた。

開催年月日： 2011年12月

会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2011年12月

会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

開催年月日： 2011年9月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Wien   国名：オーストリア共和国  

開催年月日： 2011年5月

開催地：Hiroshima   国名：日本国  

開催年月日： 2010年9月 - 2010年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：筑波   国名：日本国  

開催年月日： 2010年9月 - 2010年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：筑波   国名：日本国  

開催年月日： 2010年9月

会議種別：口頭発表（一般）  

開催地：Vienna   国名：オーストリア共和国  

開催年月日： 2010年2月 - 2010年3月

会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

開催年月日： 2009年7月

開催地：大阪   国名：日本国  

開催年月日： 2009年6月 - 2009年7月

開催地：アムステルダム   国名：オランダ王国  

開催年月日： 2008年11月

会議種別：口頭発表（一般）  

開催地：Nara-ken New Public Hall   国名：日本国  

開催年月日： 2008年11月

会議種別：口頭発表（一般）  

開催地：Nara-ken New Public Hall   国名：日本国  

開催年月日： 2008年11月

会議種別：口頭発表（一般）  

開催地：Nara-ken New Public Hall   国名：日本国  

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

Objectives: Measurement of fat fraction (FF) in the salivary glands is important in such diseases as Sjogren'ssyndrome, and it can be performed with MR spectroscopy. However, there is a limit in clinical application due to the complicated manipulations. A new magnetic resonance imaging (MRI) method, named mDIXON Quant, is convenientfor clinical application. The aim of this study was to estimate FF in the salivary glands using two different methods,mDIXON Quant and MR spectroscopy, and then to investigate the clinical usefulness of mDIXON Quant incomparison with MR spectroscopy.Methods: Sixteen healthy volunteers were enrolled in this study. They received two types of MRI examination,mDIXON Quant (6-point DIXON method) and MR spectroscopy (PRESS Single TE method), to measure FF in theparotid and submandibular glands. Ten subjects were also scanned by PRESS Multi TE method to determine theeffect of T2 value. On mDIXON Quant images, the regions of interest were set on both sides of the parotid andsubmandibular glands using the obtained FF map to determine FF.Results: 1. High correlation was observed in FF measured by mDIXON Quant and PRESS (Single TE) (slope=1.07, R2=0.960). 2. T2 value of the fat peak calculated by PRESS (Multi TE) was greater than T2 value of the water peak. 3. Even in taking the effect of T2 value by Multi TE method into account, a high correlation between mDIXON Quantand PRESS (Multi TE) was observed (slope=0.594, R2=0.964).Conclusions: The mDIXON Quant method appeared to be effective for FF measurement in the salivary glandsbecause the values obtained by mDIXON Quant correlated well with those by MR spectroscopy.

会議種別：口頭発表（一般）  

国名：日本国  

Attempt for the estimation of the concentration of the Gd-contrast medium. Phantom study and clinical application.

会議種別：口頭発表（招待・特別）  

開催地：長崎   国名：日本国  

The state of imaging diagnosis of cervical lymph nodes.

会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：新潟   国名：日本国  

The role of the Ultrasonography for the diagnoses of the patients with oral cancer.

会議種別：口頭発表（一般）  

開催地：岡山   国名：日本国  

Sonographic texture characterizationof the parotid gland of the patient with the xerostomia

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

T1 measurement by the Look-Locker sequence. The phantom study and the application to the head and neck lesion

会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

Attempt for the estimation of the concentration of the Gd-contrast medium. Phantom study and clinical application.

会議種別：口頭発表（一般）  

開催地：名古屋   国名：日本国  

Quantitative analysis of sonographic images of the salivary gland: Comparison between the sonographic findings and the sialographic findings

記述言語：英語  

国名：日本国  

Objectives: Measurement of fat fraction (FF) in the salivary glands is important in such diseases as Sjogren'ssyndrome, and it can be performed with MR spectroscopy. However, there is a limit in clinical application due to the complicated manipulations. A new magnetic resonance imaging (MRI) method, named mDIXON Quant, is convenientfor clinical application. The aim of this study was to estimate FF in the salivary glands using two different methods,mDIXON Quant and MR spectroscopy, and then to investigate the clinical usefulness of mDIXON Quant incomparison with MR spectroscopy.Methods: Sixteen healthy volunteers were enrolled in this study. They received two types of MRI examination,mDIXON Quant (6-point DIXON method) and MR spectroscopy (PRESS Single TE method), to measure FF in theparotid and submandibular glands. Ten subjects were also scanned by PRESS Multi TE method to determine theeffect of T2 value. On mDIXON Quant images, the regions of interest were set on both sides of the parotid andsubmandibular glands using the obtained FF map to determine FF.Results: 1. High correlation was observed in FF measured by mDIXON Quant and PRESS (Single TE) (slope=1.07, R2=0.960). 2. T2 value of the fat peak calculated by PRESS (Multi TE) was greater than T2 value of the water peak. 3. Even in taking the effect of T2 value by Multi TE method into account, a high correlation between mDIXON Quantand PRESS (Multi TE) was observed (slope=0.594, R2=0.964).Conclusions: The mDIXON Quant method appeared to be effective for FF measurement in the salivary glandsbecause the values obtained by mDIXON Quant correlated well with those by MR spectroscopy.

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開催年月日： 2024年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：盛岡   国名：日本国  

開催年月日： 2023年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡市   国名：日本国  

【目的】口内法X線線撮影において、撮影評価の参考指標を自動で提示できるシステムの作成を目指す。 【対象と方法】口内法X線撮影装置とImaging plate（IP）を用い、撮影実習用模型の右側上顎第一大臼歯部を撮影した509画像を対象とし、IPの位置や投影角度など8項目で分類を行った。 分類処理には深層学習モデルVision Transformerを適用し，ImageNetを用いて分類タスクで事前学習したモデルに対してファインチューニングを行った。 【結果】IP裏表、中心線位置などの認識精度は90%を超えていたが、水平・垂直的投影角度やIPの上下的・近遠心的位置は80％台と相対的に低かった。 【結論】精度の低い項目は、画像分類に偏りがあったため、分類の再定義と撮影追加によりさらなる検討を試みたい。 【謝辞】本研究に際し、ご協力いただいた福岡工業大学山本研究室配属の平田勇貴様、浦博登様、大原一晃様に深く感謝いたします。

開催年月日： 2023年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡市福岡歯科大   国名：日本国  

66歳　男性 2023年1月に下顎右側小臼歯部の疼痛および口腔前庭部の腫脹が発現。圧排により歯肉溝から浸出液を認め、近歯科医院を受診。パノラマでX線透過像を指摘され、2月27日近医院口腔外科を紹介受診。エナメル上皮腫疑いの診断となり、生検開窓術を施行。SCCの病理診断にて、3月20日九州大学病院口腔外科を紹介受診した。 MR画像を経時的に観察すると、下顎正中〜右側小臼歯部に単胞性の囊胞性病変が認められ、内部に充実成分が認められた。この軟組織は徐々に増加し、最終的に顎骨外へと浸潤した。病変内のADC値は、軟組織、液性成分いずれも一般的な囊胞性病変や歯原性良性腫瘍より低い値を呈していた。 病理所見では、扁平上皮癌による囊胞内充満が観察された。囊胞上皮には、柵状配列を示す基底層を有し細胞・構造異型が乏しい領域が一部観察され、その領域から上皮性異形成、腫瘍部への移行像を認め、この顎骨内病変が歯原性上皮起源であることが示唆された。また、病巣周囲への浸潤も認められた。以上より、下顎骨囊胞から発生した原発性骨内癌と考えられた。

開催年月日： 2023年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡市福岡歯科大学   国名：日本国  

【背景】リンパ上皮性囊胞は、側頸部や耳下腺部にみられる境界明瞭な可動性、無痛性の腫脹を示す鰓裂囊胞であり、超音波所見は均一な低エコーを示すと考えられている。 【目的】内部エコーを認めるリンパ上皮性囊胞の4例を経験し、その画像所見と病理組織学的所見を比較検討したので報告する。 【症例および方法】 症例は当科で画像検査を施行し、病理組織学的にリンパ上皮性囊胞と診断された4例で、超音波検査での内部エコー、対流の有無、ドプラ信号、MRI検査でのT1強調画像、T2強調画像での信号強度、ADC値と病理組織学的所見を対比した。 【結果】いずれの症例にも囊胞腔内にコレステリン結晶や泡沫細胞、ケラチンなどの反射体が存在した。超音波で対流を示した2症例はADC値が高く、粘稠性の低い液体の中で反射体が移動したと考えられたのに対し、対流のない2症例はADC値が低く、内部の反射体の移動が制限されていると考えられた。 【結語】内部エコーを有するリンパ上皮性囊胞も存在することを念頭に、診断を進める必要があることが示唆された。

開催年月日： 2023年5月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

開催年月日： 2020年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：開催場所　北九州　(on line)   国名：日本国  

症例は70歳男性。右側上顎部に硬結を触れる腫瘍を主訴に来院。CTでは、上顎腫瘍と右側顎下および左側上頸部にリンパ節転移を認めた。PET/CTにて、原発巣と頸部リンパ節の集積と骨破壊を伴わない椎骨骨髄のびまん性集積がみられた。生検施行し、扁平上皮癌と診断。約１ヶ月後、原発巣と頸部リンパ節が著明に増大していた。その後、腫瘍切除術および両側頸部郭清術後、化学放射線治療を行なった。WBC、G-CSF値は、入院時に高値であったが、腫瘍切除後に著明に減少しており、G-CSF産生腫瘍と判明した。また、経過観察中に肺転移を認め、転移の増大とともにWBC、CRPの上昇が見られた。 G-CSF 産生腫瘍は悪性度が高く、進行が極めて早いものが多い。PET/CTで椎骨にびまん性の骨髄集積を認め、WBC、CRP高値を伴う場合はG-CSF産生腫瘍を考慮する必要がある。また、治療後にWBC、CRPの上昇がある場合、局所再発のみならず遠隔転移の精査が必要である。

開催年月日： 2020年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：開催場所　北九州　(on line)   国名：日本国  

【背景】胸鎖関節は頸部CTでは下端付近になることが多く、口腔癌の転移部位としては稀である。今回、胸鎖関節に腫瘤性病変を認めた2症例を経験したため報告する。 【症例1】84歳、男性。右側舌癌術後1年6カ月のCTにて右側胸鎖関節部に骨破壊を伴う腫瘤を認めた。PET-CTでは胸鎖関節、腰椎および縦隔などのリンパ節に異常集積を認め、多発転移と診断された。 【症例2】88歳、男性。右側舌癌術後3カ月のCTにて右側胸鎖関節部に腫瘤を認め、鎖骨近位端には骨の断裂を認めた。PET-CTでは胸鎖関節以外に集積は認めなかった。問診にて転落の既往があることが判明し、生検では癌組織の所見を認めないことより、骨折と診断された。 【まとめと考察】悪性腫瘍経過観察中のCTで胸鎖関節部に腫瘤性病変を認めた場合は転移を疑い、第一に撮影範囲内に他病変がないか確認する必要がある。次にPET-CTにて全身のスクリーニングを行う事が必要であると考えられた。

開催年月日： 2020年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：開催場所　北九州　(on line)   国名：日本国  

【背景】胸鎖関節は頸部CTでは下端付近になることが多く、口腔癌の転移部位としては稀である。今回、胸鎖関節に腫瘤性病変を認めた2症例を経験したため報告する。 【症例1】84歳、男性。右側舌癌術後1年6カ月のCTにて右側胸鎖関節部に骨破壊を伴う腫瘤を認めた。PET-CTでは胸鎖関節、腰椎および縦隔などのリンパ節に異常集積を認め、多発転移と診断された。 【症例2】88歳、男性。右側舌癌術後3カ月のCTにて右側胸鎖関節部に腫瘤を認め、鎖骨近位端には骨の断裂を認めた。PET-CTでは胸鎖関節以外に集積は認めなかった。問診にて転落の既往があることが判明し、生検では癌組織の所見を認めないことより、骨折と診断された。 【まとめと考察】悪性腫瘍経過観察中のCTで胸鎖関節部に腫瘤性病変を認めた場合は転移を疑い、第一に撮影範囲内に他病変がないか確認する必要がある。次にPET-CTにて全身のスクリーニングを行う事が必要であると考えられた。

開催年月日： 2019年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：岡山市岡山大学歯学部   国名：日本国  

【症例】90歳男性。右側下顎に疼痛と出血を伴う腫瘤を認めた。 【所見】CTにて右側下顎臼歯部から頬側に広がる腫瘤を認めた。左側頸部・鎖骨上窩・縦隔・左肺門に均一に造影される腫大リンパ節を認め、左上葉にはconsolidationを認めた。PET-CTにて、腸骨・副腎にも集積を認めた。MRIにて下顎病変はT2強調像で均一な軽度高信号、ADC値は１.０x１０−３mm2/sであり、一般的な口腔癌の所見とは異なった。肺癌およびその転移と判断し、下顎も一連の病変との画像診断となった。口腔内細胞診は低分化癌であり、喀痰細胞診では口腔内の腫瘍細胞に類似していた。口腔内生検・腫瘍マーカーなども加味し、下顎病変は肺癌の骨転移との最終診断となった。 【結語】下顎腫瘤を初発症状とした肺癌転移症例の一例を経験した。多数のリンパ節の腫大より悪性リンパ腫との鑑別を要したが、腫脹リンパ節の局在・MR信号強度・ADC値・内部エコー等が鑑別の補助となった。通常の口腔癌と異なる所見を認めた場合、他臓器からの遠隔転移の可能性も想定する必要があると考えられた。

開催年月日： 2019年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：北九州市　　AIMビル   国名：日本国  

開催年月日： 2019年9月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：熊本   国名：日本国  

Main text : Objectives: We aimed to present the utility of DK in orofacial region by comparing the parameters of DK and ME by means of the goodness of fit, the correlations of the parameters of two methods, and the effectiveness in differential diagnosis among various kinds of orofacial tumors. Methods: One hundred and thirty-one patients underwent MR examination including EPI-DWI with 4 b-values (0, 500, 1000 and 1500 s/mm2). The ADC was obtained by the ME model. The DK parameters were estimated as apparent diffusion coefficient of Gaussian distribution (Dapp) and apparent kurtosis coefficient (Kapp). The Akaike Information Criterion was used to evaluate the goodness of fit. Then, the correlations of two methods were evaluated. These parameters were compared among cyst, benign and malignant tumors. Results: The DK showed significantly better goodness of fit than the ME model (p<0.001). Dapp and ADC showed strong positive correlation (ρ=0.922) while Dapp and Kapp presented a strong negative correlation (ρ = -0.764). So, ADC and Kapp presented in a similar pattern (ρ=-0.92). Regarding the differential diagnosis, all parameters indicated significant differences among three groups (p<0.05). Dapp and ADC of cysts were the highest, while those of malignant tumors were the lowest. Conversely, Kapp showed opposing results as 0.450.60, 1.510.40 and 0.940.24 of cyst, benign and malignant tumors, respectively. Conclusion: Given the better goodness of fit and the characteristic parameters of each category, the DK model is useful for the differential diagnosis in the orofacial tumors.

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

【目的】 ADCの分布をガンマ分布とするモデル(GD model)を顔面部拡散強調画像に応用し、有用性を検討する事。 【方法】 Philips社製1.5T装置においてEPI型拡散強調画像 b factor (0,500,1000,1500s/mm2)を撮像された腫瘍を対象とした。悪性76例（悪性リンパ腫：14, SCC：54〔高分化：38,中低分化：15〕 悪性唾液腺腫瘍：7, その他：1）、良性27例（多形腺腫：6, 脈管系腫瘍：14,その他：7）である。信号強度変化よりshape parameter（k）およびscale parameter(Θ)を算出し、GDの曲線下面積ADC<1.0x10-3mm2/s, 1.0x10mm2/s-3 <ADC<3.0x10-3mm2/s, ADC>3.0 x10-3mm2/sをf1, f2, f3とし、細胞成分、間質成分、灌流成分を反映すると想定し、各腫瘍の特徴を検討した。 【結果】 1. 悪性腫瘍は、良性腫瘍に比較し、有意に小さなkを持ち、大きなf1,小さなf2を示した。 2. f1は、悪性リンパ腫, SCC, 悪性唾液腺腫瘍, 多形腺腫、脈管系腫瘍の順に減少し、特徴的であった。f3においては、MLが小さく、脈管系腫瘍で大きかった。 3. SCCにおいては、中低分化群が、高分化群に比較し有意に高いf1を示し、高い細胞成分が示唆された。 【結論】 GD model解析は、良悪性鑑別に有用であり、得られたパラメーターは各病変の特徴を反映すると考えられた。

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

【目的】脂肪抑制T1強調像が悪性腫瘍、多形腺腫、Warthin腫瘍との鑑別に有効であるか検討すること。 【方法】2016年9月から2019年3月までにMRI検査を行い病理組織が確定した55例(Warthin腫瘍19例,悪性腫瘍10例,多形腺腫26例)を対象とした。T1強調像、脂肪抑制T1強調像、T2強調像(もしくはSTIR像)、拡散強調画像(b値:0,1000s/mm2)を評価した。T1強調像、脂肪抑制T1強調像、T2強調像では信号強度、T1強調像で高信号かつT2強調像で低信号を呈する領域の有無を検討した。拡散強調像からはADC値を算出した。 【結果】多型腺腫のADC値は、Warthin腫瘍や悪性腫瘍と比較して有意に高値であった。Warthin腫瘍と悪性腫瘍の間には有意差を認めなかった。多形腺腫および悪性腫瘍は多彩な信号強度を呈するにも関わらず、T1強調像で高信号かつT2強調像で低信号を呈する嚢胞状領域はWarthin腫瘍で有意に認められた。 【考察】ADC値による３群の鑑別は有効であるが、Warthin腫瘍と悪性腫瘍の間ではオーバーラップが大きく診断に苦慮することも多い。Warthin腫瘍では、T1強調像、特に脂肪抑制T1強調像で高信号領域が特異的に検出され、嚢胞状構造に貯留した高タンパク・粘稠な液体を反映すると考えられた。この所見は両者の鑑別の補助になると考えられた。

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

【目的】 頭頚部病変に対し、マルチスライスSE法により得られたT1強調画像（MS-SE：スライス厚3mm）とCompressed SENSEを併用した3D T1TFE法により得られた画像（CS-3D-T1TFE：スライス厚1mm）との画質の比較検討を行なった。 【方法】 頭頚部病変を有する患者30名。使用装置はPhilips社製 Ingenia 3.0T。MS-SE画像（Dixon法併用）およびCS-3DT1TFE画像（Dixon法併用）を比較した。2名の歯科放射科医が、病変の検出、モーション、金属、拍動性の各アーチファクト、脂肪抑制と血管信号の均一性、全体的な画質に関して5段階の視覚評価を行なった。さらに両側咬筋、内側翼突筋、舌根部において、SNRを算出した。 【結果】 モーションアーチファクト、拍動性アーチファクト、血管信号の均一性の評価項目においてCS-3D-T1TFEが有意に高かった。その他の項目において両者は同等の評価であった。SNRに関しては、各部位において両者は同等あるいはCS-3D-T1TFEが有意に高かった。 【結論】 撮像時間が大幅に短縮されたCS-3D-T1TFE画像は、MS-SE画像と比較して同等あるいは高いSNRを保ちながら、その高速化によりモーションアーチファクトが軽減された。また、Dixon法を併用することで金属アーチファクトがMS-SEと同程度に抑制され、血管内の信号強度はMS-SEよりも均一性が保たれた。

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

【目的】簡易IVIM法を顔面部拡散強調画像に応用し、各々の腫瘍の性質を捉え、鑑別診断における有用性を検討する事。 【方法】 Philips社製1.5T装置においてEPI型拡散強調画像 b factor (0,500,1000 s/mm2)を撮像された腫瘍を対象とした。悪性腫瘍79例（悪性リンパ腫：14, SCC：57 悪性唾液腺腫瘍：7,その他：1）および良性腫瘍33例（多形腺腫：13,脈管系腫瘤：14,その他：6）である。ADCの他にSumiらの提唱する簡易IVIM法(AJNR2013)を参考にし、真の拡散係数(D)および灌流の割合（f）を算出した。これらを用いて、各腫瘍の鑑別に有用か否かを検討した。 【結果】 1. 悪性腫瘍は、良性腫瘍に比較し、ADC,Dとも有意に低値であった。fに関しては有意差がなかったが、良性腫瘍に多くの脈管系腫瘍が含まれるためと考えられた。 2. ADC,Dとも、MLが最も低く、SCC, 悪性唾液腺腫瘍、多形腺腫、脈管系腫瘍と有意差を認めた。SCCは、多形腺腫、脈管系腫瘍より有意に低かった。多形腺腫は、ADC, Dとも悪性唾液腺腫瘍より高い傾向であったが、有意差は認めなかった。腺様嚢胞癌の3例が高いADC, Dを呈したためと思われる。 3. fに関しては、MLが最も低値で、脈管系腫瘍が最も高値であった。多形腺腫は悪性唾液腺腫瘍より有意に低値であった。 【結論】 MLにおける低いD,f、脈管系腫瘍における高いD,fは特徴的であった。

開催年月日： 2019年6月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

Objectives: The first purpose is to compare the goodness of fit among mono-exponential (ME) model, IVIM model and Gamma distribution (GD) model and evaluate the correlation among these parameters. The second was to compare them between benign and malignant tumors. Methods: 47 patients underwent 3T-MRI examination including TSE-DWI sequences with 6 b-values (0-1000 s/mm2). ADC was obtained by ME model, D, D*, and f were obtained by IVIM model. The shape parameter k, scale parameter θ and fractions of diffusion (ƒ1, ƒ2, ƒ3 which represented cell component, parenchyma and perfusion component, respectively) were estimated by the GD model. The Akaike Information Criterion was used for the evaluation of the goodness of fit. Then, the correlation among these parameters and the differences of the parameters between benign and malignant tumors were evaluated. Results: 1. Both GD and IVIM models showed better goodness of fit than ME model. 2. ƒ1 showed the negative correlations with ADC (𝞀=-0.85) and D (𝞀=-076). 3. ƒ3 showed the positive correlation with ADC (𝞀=0.46), D (𝞀=0.30) and f (𝞀=0.65). 4. The malignant tumor showed significantly lower D, lower k and higher ƒ1 value, which suggested the higher cellularity. Conclusions: Given the better goodness of fit and the correlation of parameters between GD model and IVIM mode, GD model might be helpful for the interpretation of the DWIs.

開催年月日： 2019年1月

記述言語：日本語  

国名：日本国  

口内法写真に人工的に欠損を作成し、ディープラーニングを利用した齲蝕診断能を評価した。

開催年月日： 2019年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：鹿児島   国名：日本国  

開催年月日： 2018年9月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：London   国名：グレートブリテン・北アイルランド連合王国(英国)  

Purposes The first purpose was to compare the distortion ratio (DR), the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and ADC value between TSE-DWI and EPI-DWI. The second purpose was to demonstrate the location gap between TSE-DWI and T2WI and to estimate ADC in various kinds of disease. Materials & Methods Firstly, 42 patients underwent MRI using TSE-DWI and EPI-DWI. The DR, SNR, CNR and ADC were compared between the two techniques. Secondly, 152 patients underwent MRI using TSE-DWI. The location gap along X- (direction of frequency encoding) and Y-axes (direction of phase encoding) was defined as the distance from the centroids of the lesion on DWIb1000 to that of T2WI. We also estimated ADC values of the lesions. Results 38 out of 42 cases were analyzed. The DR of TSE-DWI was significantly less than that of EPI-DWI. The SNR as well as CNR of TSE-DWI were significantly higher than that of EPI-DWI. The ADC values of TSE-DWI were significantly higher than those of EPI-DWI in palatine tonsils and submandibular glands. However, ADC values of both sequences showed no significant differences in lesions and parotid glands. In the group of TSE-DWI, 127 out of 152 cases were analyzed. The deviations along X-axis were 0.53±1.34 in lesion and 0.25±0.56 mm in spinal cord and that along the Y-axis were 0.34±1.61 and 0.73±0.82 mm, respectively. Regarding the ADC values, cysts and cystic-like lesions presented the highest values followed by benign tumors and squamous cell carcinoma, while malignant lymphoma showed the lowest value. Conclusions TSE-DWI can produce less distortion and higher image quality than EPI-DWI, while TSE-DWI possibly exhibits different ADC values. Therefore, the TSE-DWI could be good alternative to EPI-DWI and is useful for the differential diagnosis.

開催年月日： 2017年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：かごしま県民交流センター 鹿児島市山下町14番50号   国名：日本国  

開催年月日： 2017年5月

記述言語：英語  

開催地：Kaohsiung   国名：台湾  

Objective: To evaluate the feasibility of utilizing Turbo Spin Echo (TSE)-diffusion weighted imaging (DWI) to detect the recurrence of oral cancer. Materials and Methods: Thirty-six patients who underwent surgery for oral cancer were enrolled. Recurrence was found in eighteen patients. Examinations were performed on a 3T-MR system and the acquired sequences consisted of T2W-TSE, TSE-DW (b values=0,1000s/mm2), and Gd-enhanced T1W-TSE. DW images were coregistered with Gd-enhanced T1W-TSE images. We evaluated the presence of a high signal area on DWI with a b value of 1000s/mm2 and that of the enhanced area on Gd-enhanced T1WI. If any enhanced areas were found, we drew an outline to identify the region of interest and then measured the ADC on the coregistered ADC map. Results: The parallel displacement of the coregistration was -0.14±0.83, -0.12±0.80 and -0.34±0.56 mm along x, y and z axis, respectively. The rotation was 0.34±0.56°, - 0.13±0.58°, and , 0.29±0.40°in three axes. Therefore, the image misregistration between the two sequences is considered to be quite small. Three recurrences could not be detected on any sequence due to the small size of the lesion. The sensitivity of recurrence was 83% on both DWI and Gd-enhanced T1WI. Moreover, the high-signal areas on DWI coincided with the enhanced areas. The specificity was 83% on DWI and 72% on Gd-enhanced T1WI. The ADC of non-recurrence (1.90±0.14x10−3mm2/s) was significantly higher than that of recurrence (1.19±0.07x10−3mm2/s) (P=0.008). Conclusions: TSE-DWI was thus found to be immune to image distortion and it was found to be useful for detecting recurrence. When contrast enhanced MRI can not be performed, then TSE-DW may be a powerful alternative diagnostic modality.

開催年月日： 2016年10月

記述言語：日本語  

開催地：福岡市サンパレス   国名：日本国  

開催年月日： 2015年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡市   国名：日本国  

線維性異形成症は、骨組織が線維結合組織に置換される疾患である。通常は思春期後には発育が停止するが、１％程度の頻度で悪性転化すると報告されている。 今回、思春期後も病変の増殖傾向があり、長期経過後に悪性転化をきたした症例を経験したので、画像所見の変遷について報告した。

開催年月日： 2015年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：仙台   国名：日本国  

目的 顎顔面領域に発生した節外性悪性リンパ腫（ML）と扁平上皮癌（SCC）患者のMRI所見の特徴を明らかにする事。 方法 ML 9例10病巣およびSCC 25例25病巣症例を対象とした。評価項目は、T1強調画像（T1WI）およびT2強調画像(T2WI)の信号濃度(SI)、みかけの拡散係数(ADC) （b値0,500,1000sec/mm2）。ダイナミック撮像を行った症例には、Time intensity curveから造影前初期、最大ピーク、最終相（造影5分後）の信号強度を求め、最大SI/初期造影前SI（MI比）、最終相SI/最大SI（EM比）と最終相SI /初期造影前SI（EI比）を算出した。有意差を認めたパラメーターに関してROC解析した。 結果 １.ML、SCCとも、T1WIでは筋肉と同程度、T2 WIではやや高い信号強度であった。 2. MLのADC値は、SCCより有意に低値を示した。 3. MLのMI比およびEI比は、SCCより有意に低くかった。前者は、MLの血流量が少ない事、後者は、細胞間質の割合が低いことを反映していると考えられた。 4. ROCの結果、ADCは、MI比、EI比より高い鑑別能を示した。 考察およびまとめ ADC値は、両者の鑑別に最も特異的な所見であった。しかし、ADCが測定困難な場合には、ダイナミック撮像によるTIC解析は、代替として有用であると考えられた。

開催年月日： 2015年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：仙台   国名：日本国  

線維性異形成症は、骨組織が線維結合組織に置換される疾患である。通常は思春期後には発育が停止するが、１％程度の頻度で悪性転化すると報告されている。今回、思春期後も病変の増殖傾向があり数度の減量術を行い、23年後に悪性転化をきたした症例を経験したので、画像所見の変遷および悪性転化した際のCTおよびMRI所見について報告する。 【症例】39歳の女性。平成3年（17歳）に他院にて右側下顎骨線維性異形成症と診断され、平成18年までに計6回にわたり減量術を受けた。平成20年に右側頬部の腫脹と反対咬合を主訴に本院口腔外科を来院した。平成22年術前矯正終了し、右側下顎骨の減量術および外科矯正を行った。平成26年4月右側下顎の増大傾向を認め、右側下顎骨の減量術を行った。切除標本の病理組織診断は線維性異形成症であった。平成26年再度右側下顎部の増大を認めた。CT、MRIおよびPET検査結果から悪性転化が疑われたため根治的手術を行った。CTでは病巣内部の骨破壊が著しく、骨破壊部は周囲に比べて造影性の低い軟組織で占有されている。MRIでは、腫瘤の全体像はT2WIで高信号、T1WIでは中程度の信号強度であり、造影効果が認められた。みかけの拡散係数は高値であり、摘出物の病理組織診断は下顎骨肉腫であった。

開催年月日： 2014年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：岡山   国名：日本国  

緒言 　Strain Elastographyは、用手的に加えた軽度の圧迫により生じた組織の変形（歪み）の分布を画像化したものである。そのため、加圧施行者依存性や再現性が問題になることがある。近年では、組織内に横波（shear wave;剪断弾性波）を発生させて、その波の伝搬速度を測定する手法が注目されている。堅い病変ほど伝搬速度が速いことを利用したものである。今回、Shear Wave imagingによる転移リンパ節の伝搬速度測定を行い、病理組織所見とあわせて評価を行ったので報告する。 対象と方法 　対象は79 才男性で、左側舌縁（T4aN2bM0）の診断で、左側舌亜全摘出術および左側根治的郭清術変法を行った。その約2ヶ月後、超音波検査にて右側顎下リンパ節に後発転移が疑われたた症例である。対象のリンパ節に関しては、術前および摘出後の標本に対して検査を行った。 装置は、ACUSON S2000 HELX(SIEMENS社)で、B mode, Power doppler modeに合わせて、ElastographyとしてVirtual Touch IQ(VTIQ)を使用し、伝搬速度を算出した。術前および摘出物のelastography画像と病理組織標本との対比をおこなった。 結果 　右側肩甲舌骨筋上頸部郭清術により摘出された顎下部転移リンパ節は、一部壊死部分があったものの、内部の大部分が腫瘍細胞で占められており、角質物の散在がみられた。 B mode　超音波画像では、全体的に不均一な内部エコーを示し、VTIQにおいては、伝播速度が高値（Vs=6〜7m/s）の領域が散在していた。同部は角質物を有する腫瘍細胞巣に相当していた。なお、比較対象として炎症性リンパ節に対してVTIQを行ったところ、伝播速度はVs=1〜3 m/sであった。 まとめと考察 　角質物を有する腫瘍細胞巣の部分が、VTIQにおける伝搬速度の速い部分（堅い部分）を示すものと考えられた。

開催年月日： 2014年10月 - 2014年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：岡山   国名：日本国  

【目的】 上顎洞内に扁平上皮癌、上顎歯肉に粘表皮癌と異なる組織系の腫瘍を有する稀な症例を経験したので、報告する。 【症例】 ７６歳男性。左側上顎臼歯部に違和感を覚え近医を受診したが、X線写真撮影にて異常所見を認めなかったため経過観察となった。その後、同部の腫脹が増大したため切開排膿処置を受けたが、明らかな排膿はみられず、症状改善もなかったことから当院へ紹介された。 初診時に口腔外からは腫脹を認めず、鼻閉感等の鼻症状はみられなかった。口腔内では左側上顎犬歯から第一大臼歯にかけて発赤・腫脹・圧痛を認めた。特に口蓋側への腫脹が強く、切開部からは浸出液様の排液がみられた。 パノラマ・デンタル口内法およびウォーターズ撮影において左側上顎洞に不透過性の亢進を認め、左側上顎臼歯部の歯槽頂はやや粗造化していた。 超音波検査により頬部に低エコー領域を認めたが、上顎洞前壁に欠損を認め、骨内腫瘤の骨外浸潤が疑われた。 CBCTでは左側上顎洞に軟組織の充満を認めた。上顎洞前壁・鼻腔側壁の一部で骨吸収が見られたが、歯槽部、口蓋などの骨は残っており、病変の広がりの把握は困難であった。 造影CTでは上顎洞と上顎臼歯部歯肉とで造影性が異なっており、上顎洞では不均一に、歯肉部では比較的一様に強く増強されていた。歯槽部、口蓋などの骨は比較的残っていた残存していた。 MRIではT1WIで筋と同程度、T2WIで不均一なやや低信号を呈した。ADC値は、上顎洞内で0.9x10-3 mm2/sと低値で、上顎臼歯部歯肉では1.5x10-3 mm2/sと高値であった。Dynamic 撮影において、上顎洞内、歯肉部とも急増漸減パターンを呈したが、peak時/造影剤投与前の信号強度比が、それぞれ2.0、2.7倍と異なっていた。TK modelを使った薬物動態解析でも血管外細胞外腔の割合(ve)が上顎洞内では0.14、歯肉部では0.29と大きな相違が見られ、上顎洞部と歯肉部での画像的病変の特徴が異なるように考えられた思われた。 FDG-PETでは病変部に一致してFDG集積(SUVmax=24.13)を認めた。 治療として全身麻酔下に左上顎骨部分切除術が施行され、最終診断は上顎洞部が扁平上皮癌、上顎歯肉部が粘表皮癌であった。 【結論】 上顎洞内に扁平上皮癌、上顎歯肉に粘表皮癌を重複した稀な一例を報告した。上顎洞内および歯肉部におけるADCや造影パターンの違いは、病変の性状を反映したものと考えられた。

開催年月日： 2013年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：キッセイ文化ホール・松本市総合体育館   国名：日本国  

pCASL を用いてガム咀嚼後の脳活動を定性的かつ定量的に評価した。検出された脳活動領域は過去のfMRIによる報告と類似していたが、感覚運動野、補足運動野などの運動野には有意な活動が認められなかった。これは、タスク特異性のBOLD 信号変化を利用するfMRI研究では、咀嚼のあり・なし(ON-OFF) 間の信号変化を統計解析していたため咀嚼運動中の脳活動を検出していたのに対し、本研究では、ガム咀嚼前後のCBF を比較しており、咀嚼運動後の脳活動を検出したためと考えられた。またこのことから、運動野の活動はガム咀嚼終了後すみやかに元のレベルに戻ることが示唆された。一方で、前頭前皮質（前頭葉）を始めとする認知機能に関連する領域の活動はガム咀嚼後にも保たれいた。

開催年月日： 2012年12月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

耳下腺深葉から傍咽頭隙に広がる巨大な腫瘤を経験した。広がりが、咀嚼筋隙に伸展し、悪性リンパ腫などの病変が疑われた。ADC や、TICでは、ワルチン腫瘍、オンコサイトーマとして矛盾しない所見であった。その伸展様式が非常に珍しいため、症例報告とした。

開催年月日： 2012年12月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

中心咬合位、安静時、開口時の咬筋のdiffusion parameterの測定をおこなった。検討項目は、ADC, FA, λ1、λ2, λ3である。開口位では、λ２、λ３が減少、FAの増加をみとめ、筋繊維が伸展により、筋線維の太さがほそくなるためと考えられた。中心咬合位では、λ１、λ２、λ３が増加、局所的に異方性が低い部分が存在していた。血流の増加や筋の変形（筋筋線維の交差）などの関与が考えられた。　咬筋の拡散異方性は、顎位によって変化するので、測定時には一定の顎位で行う必要があると考えられた。

開催年月日： 2012年12月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

脳血流量を測定することでガム咀嚼に関連する脳活動を定量的かつ非侵襲的に解析する。pCASLをつかって、ガム咀嚼前後の脳血流量(CBF)を算出した。ガム咀嚼後の脳血液循環をみているので、中心前回などの運動野には増加がみられず、主に前頭葉を中心とした領域に活動が認められ、その他、側頭葉の一部、辺縁系である海馬傍回、視床に血流の増加が認められた。ガム咀嚼後、下前頭回、眼窩前頭皮質、海馬傍回、視床、下側頭回といった、記憶・学習・意欲・認知などに関係のある領域に、有意な血流増加が認められた。

開催年月日： 2012年11月

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

神経症腫は、口腔領域の生じることは比較的すくなく、さらに嚢胞様構造を伴うことは、まれである。今回、舌に生じた症例を経験したので文献的考察を加えて報告した。

開催年月日： 2012年10月

会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

開催年月日： 2012年10月

会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

開催年月日： 2012年10月

記述言語：日本語  

国名：日本国  

開催年月日： 2012年9月 - 2012年11月

国名：ドイツ連邦共和国  

OBJECTIVES: Background: Mass-like lesions of the tongue include a variety of lesions, benign or malignant tumors, cysts, benign neoplasms and hypertrophy. In our institute, ultrasonography is the first choice of the imaging procedures for these lesions, because of its non-invasiveness and less expensiveness. After ultrasonographic examination, it is determined whether we need further diagnostic imaging, histopathological inspection or whether we can predict its prognosis. Objective: The aim of this study is to describe the spectrum of tongue masses examined by ultrasonography in our department from January 2007 to December 2011, except squamous cell carcinoma, and to describe their subsequent managements. MATERIALS AND METHODS: Thirty cases were included in this study. All the cases underwent ultrasonography. The case clinically diagnosed as squamous cell carcinoma was excluded. Ultrasonography was performed on 12MHz(Logiq7, GE Healthcare) or 13MHz (Sequoia512, Mochida Siemens Medical Systems) linear probe. Eighteen of 30 cases underwent histopathological inspection, and others were clinically diagnosed by long period follow-up (at least one years or more) or other image inspection (CT and/or MRI). A retrospective review was performed for all the cases. RESULTS: Results are listed below (Table). Thirteen of 30 cases (43.3%) were hemangiomas, and others were cysts (3), Schwannomas (2), fibroma or fibrous tumors (4), granulation tissues (4), Lipoma (1) and malignant tumors (3). Subsequent management, need for further diagnostic imaging, histopathological inspection or prediction of prognosis , was determined based on the ultrasonographic findings; size, margin shape, location, presence or absence of capsule, vascularity, etc. and by the clinical symptoms. CONCLUSIONS: Twenty-seven (90%) of 30 cases were benign lesion and 12 (44.4%) of them needed no treatment. Ultrasonography was useful to determine subsequent management as well as imaging diagnosis.

開催年月日： 2012年9月

開催地：Leipzig   国名：ドイツ連邦共和国  

Objective To evaluate the utility of both permeability and diffusion MRI for both predicting and monitoring the histopathological response of oral squamous cell carcinoma to CRT. Material and Methods This study included 35 patients who underwent dynamic contrast-enhanced MRI (DCE-MRI). The axial DCE scan consisted of a 10 slice, 3D-T1 fast-field echo sequence. A T10 map was estimated before contrast medium injection by the dual flip angle method (5° and 15°) and the signal intensity of tissue was converted into the concentration of contrast medium in tissue (Ct (t)). The data were analyzed using a TK model. Ktrans is influx forward volume transfer constant (into EES(extravascular extracellular space)) from plasma), ve is fractional volume of EES and vp is the fractional volume of plasma. A predefined model arterial input function (AIF) was used for Cp (t), therefore, we did not take individual AIF into account. Axial DW images were also acquired and an ADC map was obtained. The motion-probing gradient was applied along the right-to-left directions, with b values of 0, 500, 1000, and 1500 s/mm2. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato’s classification. These criteria grade the tumor response from I to IV. Patients with grades IIb, III and IV are considered to be responders (n=24), while those with grades I and IIa are considered to be non-responders (n=24). Results None of the pre-CRT parameters were significantly different between responders and non-responders. The post-CRT ve of the responders (0.394±0.016) was significantly higher than that of the non-responders (0.288±0.023) (P=0.01). The change in the ve between the pre- and post-CRT of the responders (0.144±0.017) was significantly larger than that of the non-responders (0.046±0.025) (P=0.003) . It was possible to measure ADC in only 21 out of 35 cases (60%), due to severe artifacts. There was no significant difference in the pre-CRT ADC values between responders ［(1.08±0.026)x10-3mm2/s］ and non-responders ［(1.08±0.04)x10-3mm2/s］ (P=0.85). The post-CRT ADC of the responders［(1.37±0.05)x10-3mm2/s］was significantly higher than that of the non-responders［(1.17±0.07)x10-3mm2/s］ (P=0.04). The increase in both ve and ADC strongly suggested a good tumor response to CRT, which reflected an increase in the EES secondary to the destruction of the cancer nest. Conclusions The increase in the ve was indicative of a good tumor response to CRT. ADC was also useful for monitoring the tumor response to CRT; however, the problem of image distortion was sometimes troublesome in the orofacial region. This pharmacokinetic analysis is therefore considered to be potentially useful for monitoring the histopathological response to CRT.

開催年月日： 2012年9月

開催地：京都   国名：日本国  

目的 Dynamic contrast enhanced(DCE)−MRI を元にした薬物動態解析および拡散強調画像を用い、SCC，悪性リンパ腫，腺系悪性，多形腺腫の特徴を把握すること。 方法 顎顔面54病変（舌SCC 35、悪性リンパ腫10、腺系悪性腫瘍4、多形腺腫5）を対象とした。DCE-MRIから得られた画像データを元にTKモデルを使用し、Ktrans, Kep, ve, vp,の各パラメータを算出した。拡散強調画像では、b factorを0,500,1000, 1500s/mm2とし、ADCを算出した。 結果および考察 1.DCE MRIの解析は全症例で可能であったが、8症例でADCの算出は不可能であった。 2.Ktransは、良性の多形腺腫が悪性腫瘍より小さく、SCCとは有意差を認めた。 3.veは、ML, SCC，腺系悪性、多形腺腫の順に大きくなり、MLと多形腺腫には有意差を認めた。ADCもveと同様の傾向であり、組織間隙の割合を強く反映していると考えられた。 悪性リンパ腫のDCE-MRIにおける急増急減型の信号強度変化は、血管細胞外腔の占める割合が小さいことに関与すると考えられた。多形腺腫においては、血漿から血管細胞外腔への移行が少なく、血管細胞外腔の占める割合も大きい事より、漸増型の信号強度変化を示すことが多いと考えられた。 結論　 コンパートメントモデル解析は、それぞれの顎顔面病変の特徴量を算出でき、鑑別診断に有効となる可能性が示唆された。 ADC値は、口腔内領域においては金属アーチファクトの影響で測定不能な症例もあり、コンパートメントモデル解析の方がより有効であると考えられた。

開催年月日： 2012年5月

会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：北九州   国名：日本国  

開催年月日： 2011年12月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：広島   国名：日本国  

開催年月日： 2011年9月 - 2011年10月

会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2011年5月 - 2011年12月

会議種別：口頭発表（一般）  

開催地：Hiroshima   国名：日本国  

開催年月日： 2010年11月

開催地：Seaoul   国名：大韓民国  

開催年月日： 2010年11月

記述言語：英語  

開催地：Seou   国名：大韓民国  

開催年月日： 2010年9月

会議種別：口頭発表（一般）  

開催地：Vienna   国名：オーストリア共和国  

開催年月日： 2008年11月

会議種別：口頭発表（一般）  

開催地：Nara-ken New Public Hall   国名：日本国  

開催地：名古屋   国名：日本国  

Digital intraoral radiography system for filmless environment

会議種別：口頭発表（一般）  

開催地：熊本   国名：日本国  

Change of microangiostructure and hemodynamics in lymph node metastases in rabbits, animal model for Doppler sonography

会議種別：口頭発表（一般）  

国名：グレートブリテン・北アイルランド連合王国(英国)  

Change of sonographic findings on cervical lymph nodes before and after preoperative radiotherapy

会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：札幌  

The early detection of cervical lymph node metastasis: The analysis of the changes of the findings of power doppler sonographic images.

会議種別：口頭発表（一般）  

開催地：高雄   国名：中華人民共和国  

Intraoral sonography of the mobile tongue:

会議種別：口頭発表（一般）  

開催地：フランクフルト   国名：ドイツ連邦共和国  

Intraoral sonography for the tongue cancer after interstitial brachytherapy

会議種別：口頭発表（一般）  

開催地：フランクフルト   国名：ドイツ連邦共和国  

The diagnosis of masses in the submandibular region

会議種別：口頭発表（招待・特別）  

開催地：札幌   国名：日本国  

Change of microangiostructure and hemodynamics in lymph node metastases in rabbits, animal model for Doppler sonography

会議種別：口頭発表（一般）  

開催地：長崎   国名：日本国  

Sonographic texture characterization of salivary gland tumors by fractal analyses

開催地：新潟   国名：日本国  

Sonographic texture characterization of salivary gland tumors by fractal analyses

会議種別：口頭発表（招待・特別）  

開催地：福岡   国名：日本国  

Clinical practice guidelines for oral and maxillofacial radiology

会議種別：口頭発表（一般）  

開催地：東京   国名：日本国  

会議種別：口頭発表（一般）  

国名：中華人民共和国  

会議種別：口頭発表（一般）  

開催地：福岡   国名：日本国  

会議種別：口頭発表（一般）  

国名：日本国  

国名：日本国  

Evaluation on changes of T2 values and ADCs of the salivary glands by acid stimulation.

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement (T(peak)) and the wash-out ratio (WR), is commonly used. Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue. The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed. The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.

記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

3T-MRIが2003年に薬事承認され、その後、ハード・ソフト面の改良により3T装置の普及が進んできたが、顎顔面領域については金属補綴物の存在による磁場の不均一や複雑な解剖などMRIに不利な条件が揃っている。しかし、昨今の技術的進歩によりそれらの問題も少しずつ克服されつつある。今回、高磁場MRIの特性と顎顔面領域に特有な問題について説明した上で、当施設における臨床の一部を以下の項目に分けて紹介した。1)造影T1強調画像。2)拡散強調画像。3)生化学的情報の取得。4)脂肪含有率の算出。5)微量成分検出への試み(CESTイメージング)。

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

ビスホスホネート投与中に上顎に発生した症例の画像を解析した。臨床症状からは薬剤性の骨髄炎を考えたが、CTで、腫瘍あるいは炎症による肉芽・膿瘍形成が疑われた。MRにてCTで低吸収の領域にも強い造影性を認め、ADCも低く、細胞密度の小さな腫瘍と考えられた。
組織診断の結果、悪性リンパ種であった。

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

口底部に生じ特異的な信号強度を呈した腺様嚢胞ガンの一例を紹介した。境界明瞭、極めて高いADC,漸増型のTICより良性腫瘍と判断したが、実際には腺様嚢胞癌であった症例。唾液腺悪性腫瘍（特に腺様嚢胞癌）では、TICやADCも極めてひろい分布をするとの報告もある。今回のケースでも自発痛があり、超音波でのacoustic shadowの存在、　Dopplerでの豊富な血流などが、悪性を示唆する所見ではないかとretrospectiveに考察された。

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：機関テクニカルレポート，技術報告書，プレプリント等  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

種別：大会・シンポジウム等 

参加者数：240

種別：大会・シンポジウム等 

参加者数：240

種別：大会・シンポジウム等 

参加者数：120

種別：査読等 

外国語雑誌　査読論文数：7

種別：学会・研究会等 

種別：査読等 

外国語雑誌　査読論文数：7

種別：査読等 

外国語雑誌　査読論文数：12

種別：大会・シンポジウム等 

参加者数：100

種別：査読等 

外国語雑誌　査読論文数：8

種別：査読等 

外国語雑誌　査読論文数：8

種別：大会・シンポジウム等 

参加者数：25

種別：大会・シンポジウム等 

参加者数：70

種別：大会・シンポジウム等 

参加者数：250

種別：大会・シンポジウム等 

参加者数：150

種別：大会・シンポジウム等 

種別：査読等 

外国語雑誌　査読論文数：9

種別：大会・シンポジウム等 

参加者数：75

種別：大会・シンポジウム等 

参加者数：20

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：50

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：150

種別：大会・シンポジウム等 

参加者数：90

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：250

種別：大会・シンポジウム等 

参加者数：80

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

参加者数：200

種別：大会・シンポジウム等 

参加者数：120

種別：大会・シンポジウム等 

参加者数：200

種別：大会・シンポジウム等 

種別：セミナー・ワークショップ

ＮＰＯ法人日本歯科放射線学会第35回生涯学習研修会「明日から使えるパノラマエックス線写真による画像診断」にて、パノラマの診断法（パノラマエックス線画像の読影ポイント）に関して参加開業歯科医に対しての講演を行った。
また、ＮＰＯ法人日本歯科放射線学会認定医委員会として、講習会後に、准認定医試験を行った。

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：セミナー・ワークショップ

種別：セミナー・ワークショップ

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：その他

種別：その他

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：幼稚園以下,　小学生,　中学生,　高校生

種別：セミナー・ワークショップ

種別：セミナー・ワークショップ

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種別：講演会

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：セミナー・ワークショップ

種別：セミナー・ワークショップ

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：その他

種別：その他

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：その他

種別：その他

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：セミナー・ワークショップ

種別：セミナー・ワークショップ

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

種別：講演会

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対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

種別：出前授業

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