Updated on 2025/06/27

Information

 

写真a

 
SANEMATSU KEISUKE
 
Organization
Faculty of Dental Science Department of Dental Science Lecturer
Graduate School of Dental Science Department of Dental Science（Concurrent）
Graduate School of Dental Science （Concurrent）
School of Dentistry Department of Dentistry（Concurrent）
Title
Lecturer
Contact information
メールアドレス
Tel
0926426312
Profile
研究概要 甘味受容体と味覚修飾物質に関する研究 味覚は、食を通して生体恒常性を維持するために不可欠な重要な感覚である。生活習慣病やそのリスクファクターである肥満は、我々の甘味に対する強い嗜好性と食生活の乱れが主な要因であると考えられている。甘味受容機構の解明は、これら生活習慣病や肥満の予防、治療に役立つ味覚修飾物質の発見や、創薬につながる可能性があり、その基礎として、甘味受容体(T1r2/T1r3)と基質との結合特性を解明することが現在緊急課題となっている。そこで人工味細胞（HEK293培養細胞に味覚受容体を強制発現させる）を用い、甘味受容体と味覚修飾物質との相互作用について解析を行っている。 教育概要 学部学生に対する口腔生理学講義、口腔生理学実習、リサーチエクスポージャーの一部を担当する。
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Research Areas

  • Life Science / Oral biological science

  • Life Science / Physiology

  • Life Science / Nutrition science and health science

Degree

  • Ph.D

Research History

  • Kyushu University Faculty of Dental Science Department of Dental Science  Lecturer 

    2019.4 - Present

  • Kyushu University Faculty of Dental Science Department of Dental Science  Assistant Professor 

    2009.5 - 2019.3

  • Kyushu University Faculty of Dental Science Department of Dental Science  Academic Researcher 

    2009.4 - 2019.5

  • Kyushu University Faculty of Dental Science Department of Dental Science  日本学術振興会特別研究員DC1 

    2006.4 - 2009.3

Education

  • Kyushu University   歯学府  

    2005.4 - 2009.3

  • Kyushu University   歯学部   歯学科

    1999.4 - 2005.3

Research Interests・Research Keywords

  • Research theme： 味覚

    Keyword： 味覚

    Research period： 2025

  • Research theme： 味覚受容体

    Keyword： 味覚受容体

    Research period： 2025

  • Research theme： Molecular mechanisms behind the interaction between sweet receptor and taste modifiers

    Keyword： Sweet receptor, Taste modifier, Human, Mouse

    Research period： 2009.5

Awards

  • 九大歯学優秀研究者賞（IF部門）

    2025.2   九州大学大学院歯学研究院  

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    分子動力学シミュレーションと人工味細胞による受容体機能解析を用いて、甘味受容体サブユニットTAS1R3の膜貫通ドメインと人工甘味料や甘味抑制物質との相互作用について調べた。細胞膜に存在する受容体が活性化する際に、細胞膜外側における人工甘味料と結合サイトでの相互作用が、受容体内の相互作用を引き起こす。それにより、結合サイトとは離れた細胞内側に存在する水素結合を切断することで、シグナル伝達が進む可能性が示唆された。この予測は、人工味細胞を用いた機能解析により強く支持された。また、人工甘味料サッカリンの結合部位のヒスチジン残基がpH感受性のマイクロスイッチとして機能し、サッカリンに対する感受性がpHにより調節されることを明らかにした。
    本研究成果は英国の雑誌「Communications Biology」に掲載された。

  • 平成29年度がん研究助成金優秀賞

    2018.1   ふくおか公衆衛生推進機構  

  • 2017 年度日本味と匂学会研究奨励賞（味部門）

    2017.9   日本味と匂学会   甘味受容体と甘味修飾物質との結合特性

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    味覚受容体再構築系を用いて、甘味抑制物質ギムネマ酸や甘味誘導物質ミラクリンの分子メカニズムの解明を行った。これらの研究成果は、Gタンパク質共役型受容体の機能特性の解明に重要な知見を与えるのみならず、甘味受容体の消化管・膵臓・脂肪細胞におけるエネルギーセンサーとしての機能制御にも新たな手段を提示するものになり、エネルギー代謝調節に関与する医薬品や機能性食品の開発などへと展開することにより、食から医療まで、幅広く貢献をすることが期待できる。

  • 歯科基礎医学会学会奨励賞

    2016.8   歯科基礎医学会   甘味受容体TAS1R2/TAS1R3におけるギムネマ酸の甘味抑制効果の分子メカニズム

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    ギムネマ酸は、植物ギムネマ・シルベスタ由来のトリテルペン配糖体で、ヒトの甘味を選択的に抑制することが知られている。しかし、その抑制の分子メカニズムについては長年不明であった。われわれは、ギムネマ酸の効果に種差（マウスには無効）があることを利用し、甘味受容体T1R2/T1R3のヒト型・マウス型およびそのキメラ体をHEK細胞に再構築し、それら各種T1R2/T1R3とギムネマ酸の相互作用を調べた。その結果、ギムネマ酸はヒト T1R2/T1R3 の甘味応答を抑制したが、マウス型 には働かず、受容体結合特性の種差が確認された。次に、ヒト・マウス・キメラ体のギムネマ酸の効果を検索したところ、ギムネマ酸感受性にはヒト T1R3 の膜貫通ドメインが不可欠であることが示唆された。また、分子モデリングによりその部位にギムネマ酸が結合することが推定された。さらに、ヒト T1R3 膜貫通領域のアミノ酸の点変異の解析により、第3、第5、第6ヘリックスで囲まれたドメインにギムネマ酸が結合している可能性が強く示唆され、かつギムネマ酸の持つグルクロノシル基が甘味抑制に重要であることを明らかにしている。
    　この研究成果は、Gタンパク質共役型受容体の機能特性の解明に重要な知見を与えるのみならず、甘味受容体の消化管・膵臓・脂肪細胞におけるエネルギーセンサーとしての機能制御にも新たな手段を提示するものになり、エネルギー代謝調節に関与する医薬品や機能性食品の開発などへと展開することにより、食から医療まで、幅広く貢献をすることが期待できる。

  • 論文賞

    2010.9   日本味と匂学会   ヒトT1R2/T1R3に対するギムネマ酸の相互作用部位の同定

Papers

  • 甘味受容体の動的活性化機構および pH 感受性機構 Reviewed

    實松　敬介、重村　憲徳

    日本味と匂学会誌   31 ( 2 )   150 - 156   2024.11

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3. Reviewed International journal

    @Sanematsu K, #Yamamoto M, #Nagasato Y, @Kawabata Y, @Watanabe Y, @Iwata S, @Takai S, @Toko K, @Matsui T, @Wada N, @Shigemura N

    Communications Biology   6 ( 1 )   340 - 340   2023.4   （ ISSN:23993642 eISSN:23993642 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer  

    The sweet taste receptor plays an essential role as an energy sensor by detecting carbohydrates. However, the dynamic mechanisms of receptor activation remain unclear. Here, we describe the interactions between the transmembrane domain of the G protein-coupled sweet receptor subunit, TAS1R3, and allosteric modulators. Molecular dynamics simulations reproduced species-specific sensitivity to ligands. We found that a human-specific sweetener, cyclamate, interacted with the mouse receptor as a negative allosteric modulator. Agonist-induced allostery during receptor activation was found to destabilize the intracellular part of the receptor, which potentially interfaces with the Gα subunit, through ionic lock opening. A common human variant (R757C) of the TAS1R3 exhibited a reduced response to sweet taste, in support of our predictions. Furthermore, histidine residues in the binding site acted as pH-sensitive microswitches to modulate the sensitivity to saccharin. This study provides important insights that may facilitate the prediction of dynamic activation mechanisms for other G protein-coupled receptors.

    DOI： 10.1038/s42003-023-04705-5

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  • Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice Invited Reviewed International journal

    Osaki, Ayana; Sanematsu, Keisuke; Yamazoe, Junichi; Hirose, Fumie; Watanabe, Yu; Kawabata, Yuko; Oike, Asami; Hirayama, Ayaka; Yamada, Yu; Iwata, Shusuke; Takai, Shingo; Wada, Naohisa; Shigemura, Noriatsu

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 23 )   2020.12

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/ijms21238958

  • Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans Reviewed

    Keisuke Sanematsu, Yuki Nakamura, Masatoshi Nomura, Noriatsu Shigemura, Yuzo Ninomiya

    Nutrients   10 ( 3 )   2018.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Sweet taste thresholds are positively related to plasma leptin levels in normal weight humans: both show parallel diurnal variations and associations with postprandial glucose and insulin rises. Here, we tested whether this relationship also exists in overweight and obese (OW/Ob) individuals with hyperleptinemia. We tested 36 Japanese OW/Ob subjects (body mass index (BMI) > 25 kg/m2 ) for recognition thresholds for various taste stimuli at seven different time points from 8:00 a.m. to 10:00 p.m. using the staircase methodology, and measured plasma leptin, insulin, and blood glucose levels before each taste threshold measurement. We also used the homeostatic model assessment of insulin resistance (HOMA-IR) to evaluate insulin resistance. The results demonstrated that, unlike normal weight subjects, OW/Ob subjects showed no significant diurnal variations in the recognition thresholds for sweet stimuli but exhibited negative associations between the diurnal variations of both leptin and sweet recognition thresholds and the HOMA-IR scores. These findings suggest that in OW/Ob subjects, the basal leptin levels (~20 ng/mL) may already exceed leptin’s effective concentration for the modulation of sweet sensitivity and that this leptin resistance-based attenuation of the diurnal variations of the sweet taste recognition thresholds may also be indirectly linked to insulin resistance in OW/Ob subjects.

    DOI： 10.3390/nu10030297

  • Binding properties between human sweet receptor and sweet-inhibitor, gymnemic acids Reviewed International journal

    Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    Journal of Oral Biosciences   2017.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.job.2017.05.004

  • Intracellular acidification is required for full activation of the sweet taste receptor by miraculin Reviewed International journal

    Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya

    Scientific reports   ( 6 )   22807   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep22807

  • Structure, function, and signaling of taste G-protein-coupled receptors Reviewed International journal

    Keisuke Sanematsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    Current Pharmaceutical Biotechnology   １５ ( １０ )   951 - 961   2014.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids Reviewed International journal

    Keisuke Sanematsu, Yuko Kusakabe, Noriatsu Shigemura, Takatsugu Hirokawa, Seiji Nakamura, Toshiaki Imoto, Yuzo Ninomiya

    Journal of Biological Chemistry   289 ( 37 )   25711 - 25720   2014.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M114.560409

  • Modulation and transmission of sweet taste information for energy homeostasis. Reviewed International journal

    Sanematsu K, Horio N, Murata Y, Yoshida R, Ohkuri T, Shigemura N, Ninomiya Y.

    Ann N Y Acad Sci.   2009.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • トリテルペン配糖体とヒト甘味受容体hT1R2/hT1R3の相互作用 Reviewed

    實松敬介、重村憲徳、中村誠司、井元敏明、二ノ宮裕三

    日本味と匂学会誌   2008.1

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 甘味受容体hT1R2+hT1R3強制発現系によるギムネマ酸の甘味抑制効果解析 Reviewed

    實松敬介、重村憲徳、井元敏明、二ノ宮裕三

    日本味と匂学会誌   2007.1

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Tas1r3遺伝子型とグルマリン感受性の関連 Reviewed

    實松敬介、安松啓子、吉田竜介、重村憲徳、二ノ宮裕三

    日本味と匂学会誌   2006.1

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3. Reviewed International journal

    Sanematsu K, Yasumatsu K, Yoshida R, Shigemura N, Ninomiya Y.

    Chemical Senses   30 ( 6 )   491 - 496   2005.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bji041

  • Receptor mechanism producing a sweet taste from plant aroma compounds

    Fuyumi Horie, Keisuke Sanematsu, Keiko Yasumatsu, Takatsugu Hirokawa, Noriatsu Shigemura, Atsuko Yamashita, Yuko Kusakabe

    Scientific Reports   15 ( 1 )   6795   2025.3   （ ISSN:2045-2322 eISSN:2045-2322 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Fruits and vegetables contain highly volatile hydrophobic small molecules responsible for their aroma, taste, and pungency. Empirically, we understand that these compounds can evoke a sweet taste; however, their specific interactions with sweet taste receptors are unclear. To address this issue, HEK293 cells expressing human and mouse sweet taste receptors TAS1R2/TAS1R3 were used to identify trans-2-hexenal (a novel sweetener) in human and cinnamyl alcohol (a sweetness inhibitor) in mice. The effects of these compounds on TAS1R2/TAS1R3 in humans and mice were evaluated alongside known hydrophobic sweet compounds, and the results showed that they elicited responses in human TAS1R2/TAS1R3 but not in mice. Conversely, some compounds inhibited the sweetness of sucralose both in vitro and in vivo. Response analysis using human and mouse chimeric TAS1R2 and point mutants of TAS1R2 using docking simulations indicated that these compounds bind to the transmembrane domain of TAS1R2 and that multiple amino acid residues are essential to generate a sweet taste. These results indicate that highly volatile hydrophobic compounds generate aroma and sweetness through a different mechanism than hydrophilic sweeteners, such as sucrose.

    DOI： 10.1038/s41598-025-89711-9

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    Other Link： https://www.nature.com/articles/s41598-025-89711-9

  • Activation Dynamics for the Taste Receptor as an Energy Sensor

    Sanematsu K., Shigemura N.

    Current Oral Health Reports   11 ( 4 )   268 - 275   2024.12

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    Publisher：Current Oral Health Reports  

    Purpose of Review: Sweet-taste receptors play a crucial role in maintaining biological homeostasis by acting as energy sensors. However, the dynamics of this receptor after binding remain unknown because previous studies have primarily examined the static binding of the sweet taste receptor in complex with ligands. This review focuses on the mechanisms underlying the allostery-mediated activation and inactivation of the transmembrane domain of the sweet taste receptor subunit, TAS1R3. Recent Findings: Molecular dynamics simulations predicted that agonist binding induces the opening of the ionic lock formed by transmembrane helices III and VI. These simulations were validated by functional assays in HEK293 cells expressing the sweet taste receptor. Summary: The allostery through the interaction between the transmembrane domain of TAS1R3 and agonist would induce the conformational change on the intracellular side of the receptor, facilitating binding with the Gα subunit.

    DOI： 10.1007/s40496-024-00391-2

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  • Relationship between olfactory and gustatory functions: The Iwaki health promotion project 2019(タイトル和訳中)

    Yamauchi Kazutaka, Matsushita Daisuke, Shimizume Nami, Kudo Reiko, Kohama Yusuke, Miyazaki Akiko, Taguchi Hiromu, Hirao Takashi, Kawabata Fuminori, Kawabata Yuko, Sanematsu Keisuke, Takai Shingo, Yamazoe Junichi, Anabuki Kenichi, Aoshima Ken, Takahashi Yoshiko, Goto Shinichi, Sasaki Akira, Shigemura Noriatsu, Matsubara Atsushi

    Auris・Nasus・Larynx   51 ( 3 )   443 - 449   2024.6   （ ISSN:0385-8146 ）

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    Language：English   Publisher：Elsevier B.V.  

  • Relationship between olfactory and gustatory functions: The Iwaki health promotion project 2019. Reviewed International journal

    @Yamauchi K, @Matsushita D, @Shimizume N, @Kudo R, @Kohama Y, @Miyazaki A, @Taguchi H, @Hirao T, @Kawabata F, @Kawabata Y, @Sanematsu K, @Takai S, @Yamazoe J, @Anabuki K, @Aoshima K, @Takahashi Y, @Goto S, @Sasaki A, @Shigemura N, @Matsubara A.

    Auris Nasus Larynx   51 ( 3 )   443 - 449   2024.3

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    DOI： 10.1016/j.anl.2023.12.009.

  • Mechanisms of Dynamic Activation and pH-dependent Sensitivity of Sweet Taste Receptor

    實松 敬介, 重村 憲徳

    The Japanese Journal of Taste and Smell Research   31 ( 2 )   150 - 156   2024   （ ISSN:13404806 eISSN:24241326 ）

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    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    甘味受容体は、糖質を感知するエネルギーセンサーとして重要な役割を果たす。生活習慣病やその主要なリスクファクターである肥満は、甘味に対する強い嗜好と食生活の乱れに密接に関連している。よって甘味受容機構制御の重要性が増しているが、受容体が活性化する動的なメカニズムは不明なままである。本総説では、筆者らが明らかにしてきたGタンパク質共役型甘味受容体サブユニットTAS1R3の膜貫通ドメインとアロステリックモジュレーターとの動的相互作用およびpH感受性マイクロスイッチについて概説する。

    DOI： 10.18965/tasteandsmell.31.2_150

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  • Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice. Reviewed International journal

    #Hirayama A, @Iwata S, #Oike A, @Kawabata Y, #Nagasato Y, @Takai S, @Sanematsu K, @Takahashi I, @Shigemura N.

    Frontiers in Cellular Neuroscience   17   1279059   2023.9

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    DOI： 10.3389/fncel.2023.1279059.

  • The Antiarrhythmic Drug Flecainide Enhances Aversion to HCl in Mice. Reviewed International journal

    @Kawabata Y, @Takai S, @Sanematsu K, @Yoshida R, @Kawabata F, @Shigemura N.

    eNeuro   10 ( 9 )   0048-23 - 23.2023   2023.9   （ eISSN:2373-2822 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Society for Neuroscience  

    Drug-induced taste disorders reduce quality of life, but little is known about the molecular mechanisms by which drugs induce taste disturbances. In this study, we investigated the short- and long-term effects of the antiarrhythmic drug flecainide, which is known to cause taste dysfunction. Analyses of behavioral responses (licking tests) revealed that mice given a single intraperitoneal injection of flecainide exhibited a significant reduction in preference for a sour tastant (HCl) but not for other taste solutions (NaCl, quinine, sucrose, KCl and monopotassium glutamate) when compared with controls. Mice administered a single dose of flecainide also had significantly higher taste nerve responses to HCl but not to other taste solutions. Compared with controls, mice administered flecainide once-daily for 30 days showed a reduced preference for HCl without any changes in the behavioral responses to other taste solutions. The electrophysiological experiments using HEK293T cells transiently expressing otopetrin-1 (Otop1, the mouse sour taste receptor) showed that flecainide rarely altered the responses to HCl. Taken together, our results suggest that flecainide specifically enhances the response to HCl in mice during short- and long- term administration. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.

    Significance Statement

    Drug-induced taste disorders reduce quality of life and can lead to nutritional disturbances. However, little is known about its molecular mechanisms. We focused on the antiarrhythmic drug flecainide inducing “unpleasant or bad taste” in human patients. Mice administered a single dose of flecainide exhibited a reduced preference for and higher taste nerve responses to HCl, sour tastants specifically. Flecainide had little change in response to HCl in HEK293T cells expressing the sour taste receptor, proton channel otopetrin-1 (Otop1). Our results suggest that flecainide enhances the responses of sour-sensing taste cells to HCl. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.

    DOI： 10.1523/ENEURO.0048-23.2023

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  • The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response. Reviewed International journal

    @Kawabata Y, @Takai S, @Sanematsu K, @Iwata S, @Kawabata F, @Kanematsu T, @Jimi E, @Shigemura N.

    FEBS Letters   597 ( 15 )   2006 - 2016   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/1873-3468.14695.

  • Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway. Reviewed International journal

    @Iwata S, @Yoshida R, @Takai S, @Sanematsu K, @Shigemura N, @Ninomiya Y.

    Nutrients   15 ( 13 )   2941 - 2941   2023.6   （ eISSN:2072-6643 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake.

    DOI： 10.3390/nu15132941

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  • Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells Reviewed International journal

    #Oike A, @Iwata S, #Hirayama A, #Ono Y, #Nagasato Y, @Kawabata Y, @Takai S, @Sanematsu K, @Wada N, @Shigemura N.

    Scientific Reports   12 ( 1 )   21246   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41598-022-25755-5

  • Examination of Taste Threshold for General Residents―From the Results of the 2019 Iwaki Health Promotion Project―

    Shimizume Nami, Kudo Reiko, Kohama Yusuke, Kawabata Yuko, Kawabata Fuminori, Sanematsu Keisuke, Uemura Nozomi, Takai Shingo, Yamazoe Junichi, Miyazaki Akiko, Taguchi Hiromu, Hirao Takashi, Miura Shiori, Goto Shinichi, Sasaki Akira, Shigemura Noriatsu, Matsubara Atsushi

    Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)   125 ( 9 )   1375 - 1383   2022.9   （ ISSN:24365793 eISSN:24365866 ）

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

    <p>　Taste is an important sense that is associated with appetite and food intake. Although many studies have been reported on taste detection tests in patients with taste disorders, few studies have been conducted in healthy subjects.</p><p>　The Iwaki Health Promotion Project is a large-scale epidemiological survey of local residents. In the present study, participants in Project 2019 were tested for sweet, salty, sour, and bitter taste thresholds, and 1027 participants for whom data were available were included in the analysis.</p><p>　A comparison of the taste thresholds among the age groups showed that the sour and salty tastes thresholds increased significantly with age, and the thresholds for all tastes was significantly lower in women than in men. In addition, decreased serum zinc levels were not necessarily associated with decreased taste, but decreased serum zinc levels and decreased taste were more frequently observed in the elderly. There were quite a few patients who were not aware of any taste disorder, even though they had a decreased sense of taste on examination. This indicates that there are potential patients with taste disorders.</p>

    DOI： 10.3950/jibiinkotokeibu.125.9_1375

    CiNii Research

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  • The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans Reviewed International journal

    Serrano J, Seflova J, Park J, Pribadi M, @Sanematsu K, @Shigemura N, Serna V, Yi F, Mari A, Procko E, Pratley RE, Robia SL, Kyriazis GA

    Molecular Metabolism   54   101339   2021.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.molmet.2021.101339

  • In vitro and in silico characterization of adiponectin-receptor agonist dipeptides Reviewed International journal

    #Lee Y, #Nakano A, #Nakamura S, @Sakai K, @Tanaka M, @Sanematsu K, @Shigemura N, @Matsui T

    npj Science of Food   5 ( 1 )   29   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41538-021-00114-2

  • Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae Reviewed International journal

    #Yamada Y, @Takai S, @Watanabe Y, @Osaki A, @Kawabata Y, #Oike A, #Hirayama A, @Iwata S, @Sanematsu K, @Tabata S, @Shigemura N.

    Biochemical and Biophysical Research Communications   557   206 - 212   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2021.04.022

  • Identification of characteristic compounds of moderate volatility in breast cancer cell lines Invited Reviewed International journal

    Tanaka, Mitsuru; Hsuan, Chung; Oeki, Masataka; Shen, Weilin; Goda, Asuka; Tahara, Yusuke; Onodera, Takeshi; Sanematsu, Keisuke; Rikitake, Tomotsugu; Oki, Eiji; Ninomiya, Yuzo; Kurebayashi, Rintaro; Sonoda, Hideto; Maehara, Yoshihiko; Toko, Kiyoshi; Matsui, Toshiro

    PLOS ONE   15 ( 6 )   2020.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0235442

  • Expression of Renin-Angiotensin System Components in the Taste Organ of Mice Reviewed

    Noriatsu Shigemura, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, Yuzo Ninomiya

    Nutrients   11 ( 9 )   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.

    DOI： 10.3390/nu11092251

  • Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits Reviewed

    Jihye Park, Balaji Selvam, Keisuke Sanematsu, Noriatsu Shigemura, Diwakar Shukla, Erik Procko

    Journal of Biological Chemistry   294 ( 13 )   4759 - 4774   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Class C G protein– coupled receptors (GPCRs) are obligatory dimers that are particularly important for neuronal responses to endogenous and environmental stimuli. Ligand recognition through large extracellular domains leads to the reorganization of transmembrane regions to activate G protein signaling. Although structures of individual domains are known, the complete architecture of a class C GPCR and the mechanism of interdomain coupling during receptor activation are unclear. By screening a mutagenesis library of the human class C sweet taste receptor subunit T1R2, we enhanced surface expression and identified a dibasic intracellular retention motif that modulates surface expression and co-trafficking with its heterodimeric partner T1R3. Using a highly expressed T1R2 variant, dimerization sites along the entire subunit within all the structural domains were identified by a comprehensive mutational scan for co-trafficking with T1R3 in human cells. The data further reveal that the C terminus of the extracellular cysteine-rich domain needs to be properly folded for T1R3 dimerization and co-trafficking, but not for surface expression of T1R2 alone. These results guided the modeling of the T1R2–T1R3 dimer in living cells, which predicts a twisted arrangement of domains around the central axis, and a continuous folded structure between transmembrane domain loops and the cysteine-rich domains. These insights have implications for how conformational changes between domains are coupled within class C GPCRs.

    DOI： 10.1074/jbc.RA118.006173

  • Effects of insulin signaling on mouse taste cell proliferation Reviewed

    Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F. Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura

    PloS one   14 ( 11 )   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expression of IR mRNA and protein in mouse taste bud cells in vivo and explored its function ex vivo in organoids, using RT-PCR, immunohistochemistry, and quantitative PCR. In mouse taste tissue, IR was expressed broadly in taste buds, including in type II and III taste cells. With using 3-D taste bud organoids, we found insulin in the culture medium significantly decreased the number of taste cell and mRNA expression levels of many taste cell genes, including nucleoside triphosphate diphosphohydrolase-2 (NTPDase2), Tas1R3 (T1R3), gustducin, carbonic anhydrase 4 (CA4), glucose transporter-8 (GLUT8), and sodium-glucose cotransporter-1 (SGLT1) in a concentration-dependent manner. Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) signaling, diminished insulin’s effects and increase taste cell generation. Altogether, circulating insulin might be an important regulator of taste cell growth and/or proliferation via activation of the mTOR pathway.

    DOI： 10.1371/journal.pone.0225190

  • Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae Reviewed

    Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Robert F. Margolskee, Noriatsu Shigemura, Yuzo Ninomiya

    Neuroscience   369   29 - 39   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phospholipase Cβ2 (PLCβ2) and transient receptor potential channel M5 (TRPM5). Indeed, some gustducin-positive taste cells have been shown to respond to bitter compounds. However, there has been no systematic characterization of their response properties to multiple bitter compounds and the role of transduction molecules in these cells. In this study, we investigated bitter taste responses of gustducin-positive taste cells in situ in mouse fungiform (anterior tongue) and circumvallate (posterior tongue) papillae using transgenic mice expressing green fluorescent protein in gustducin-positive cells. The overall response profile of gustducin-positive taste cells to multiple bitter compounds (quinine, denatonium, cyclohexamide, caffeine, sucrose octaacetate, tetraethylammonium, phenylthiourea, L-phenylalanine, MgSO4, and high concentration of saccharin) was not significantly different between fungiform and circumvallate papillae. These bitter-sensitive taste cells were classified into several groups according to their responsiveness to multiple bitter compounds. Bitter responses of gustducin-positive taste cells were significantly suppressed by inhibitors of TRPM5 or PLCβ2. In contrast, several bitter inhibitors did not show any effect on bitter responses of taste cells. These results indicate that bitter-sensitive taste cells display heterogeneous responses and that TRPM5 and PLCβ2 are indispensable for eliciting bitter taste responses of gustducin-positive taste cells.

    DOI： 10.1016/j.neuroscience.2017.10.047

  • Leptin suppresses sweet taste responses of enteroendocrine STC-1 cells Reviewed International journal

    Jyotaki Masafumi, Keisuke Sanematsu, Noriatsu Shigemura, Ryusuke Yoshida, Yuzo Ninomiya

    Neuroscience   ( 332 )   76 - 87   2016.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep22807

  • Angiotensin II Modulates Salty and Sweet Taste Sensitivities. Reviewed International journal

    Noriatsu Shigemura, Ryusuke Yoshida, Shusuke Iwata, Keisuke Sanematsu, Tadahiro Ohkuri, Nao Horio, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    J Neurosci.   33 ( 15 )   6267 - 6277   2013.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Modulation of sweet responses of taste receptor cells. Reviewed International journal

    Ryusuke Yoshida, Mayu Niki, Masafumi Jotaki, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    Semin Cell Dev Biol.   24 ( 3 )   226 - 231   2013.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats. Reviewed International journal

    Li YinJi, Akiko Kukita, Toshiyuki Watanabe, Toshio Takano, Pengfei Qu, Yuzo Ninomiya, Toshio Kukita

    Lab Invest.   92 ( 12 )   1777 - 1787   2012.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Endocannabinoids selectively enhance sweet taste. Reviewed International journal

    Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y.

    Proc Natl Acad Sci U S A.   2010.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin. Reviewed International journal

    Horio N, Jyotaki M, Yoshida R, Sanematsu K, Shigemura N, Ninomiya Y.

    J Pharmacol Sci.   2010.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice. Reviewed International journal

    Yasumatsu K, Ohkuri T, Sanematsu K, Shigemura N, Katsukawa H, Sako N, Ninomiya Y.

    BMC Neurosci.   2009.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Variation in umami perception and in candidate genes for the umami receptor in mice and humans. Reviewed International journal

    Shigemura N, Shirosaki S, Ohkuri T, Sanematsu K, Islam AA, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.

    Am J Clin Nutr.   2009.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y. Reviewed International journal

    Genetic and molecular basis of individual differences in human umami taste perception.

    PLoS One.   2009.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Reviewed International journal

    Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y.

    Diabetes   2008.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Taste responsiveness of fungiform taste cells with action potentials. Reviewed International journal

    Yoshida R, Shigemura N, Sanematsu K, Yasumatsu K, Ishizuka S, Ninomiya Y.

    J Neurophysiol.   2006.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Taste receptor cells responding with action potentials to taste stimuli and their molecular expression of taste related genes. Reviewed International journal

    Yoshida R, Sanematsu K, Shigemura N, Yasumatsu K, Ninomiya Y.

    Chemical Senses   30   I19 - i20   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjh092

  • 脂肪酸の苦味抑制効果：ヒト、マウス、ウシを用いた精神物理学的、分子遺伝学的、神経行動学的解析 Reviewed

    安松啓子、斉藤幸子、Ding Ming、村田裕子、實松敬介、重村憲徳、Robert F. Margolskee、ニノ宮裕三

    日本味と匂学会誌   2005.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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Books

  • 月刊化学Vol.78 No.8　甘味受容体の動的な活性化・不活性化 メカニズムの解明ーー血糖値をコントロールできる甘味修飾物質の開発を目指して

    @實松敬介、@重村憲徳（Role：Joint author）

    化学同人  2023.8 

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    Responsible for pages：33-37   Language：Japanese   Book type：General book, introductory book for general audience

  • 糖質・甘味のおいしさ評価と健康・調理・加工 (山野善正 監修)　第4編3章 ギムネマ酸の相互作用による甘味受容体抑制機構

    @實松敬介（Role：Joint author）

    エヌ･ティー･エス  2022.1 

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    Responsible for pages：315-323   Language：Japanese   Book type：Scholarly book

  • Clinical Neuroscience, 甘味受容体と味覚修飾物質

    @實松敬介, @重村憲徳, @二ノ宮裕三（Role：Joint author）

    2019.12 

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    Responsible for pages：vol.37 no.12 （2019‒12）, 1444-1447   Language：Japanese   Book type：Scholarly book

  • 化学受容の科学：味覚受容体

    實松　敬介、重村　憲徳、二ノ宮　裕三

    2012.2 

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    Responsible for pages：48-57   Book type：General book, introductory book for general audience

  • 疾患モデルマウス表現型解析指南：味覚

    實松　敬介、二ノ宮　裕三

    中山書店  2011.12 

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    Responsible for pages：128‐133   Book type：General book, introductory book for general audience

  • 肥満と糖尿病 ：甘味味覚の日内変動は？

    實松　敬介、二ノ宮　裕三（Role：Joint author）

    丹水社  2010.3 

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    Responsible for pages：Vol.9 No.2: 211-212   Book type：General book, introductory book for general audience

  • 内分泌・糖尿病・代謝内科：レプチンによる甘味感受性制御

    重村 憲徳, 實松 敬介, 二ノ宮 裕三

    科学評論社  2012.4 

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    Responsible for pages：34(4)371-378   Book type：General book, introductory book for general audience

  • 細胞工学：特集感覚センサー「味覚センサーの分子進化と多様性」

    重村憲徳、大栗弾弘、實松敬介、二ノ宮裕三（Role：Joint author）

    秀潤社  2007.7 

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    Responsible for pages：26, 890-893   Book type：General book, introductory book for general audience

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Presentations

  • Elucidating Dynamic Allostery in the Transmembrane Domain of TAS1R3, a Sweet Taste Receptor Subunit

    Keisuke Sanematsu, Masato Yamamoto, Yuki Nagasato, Yuko Kawabata, Yu Watanabe, Shusuke Iwata, Shingo Takai, Kiyoshi Toko, Toshiro Matsui, Naohisa Wada, Noriatsu Shigemura

    Kyudai Oral Bioscience OBT Research Center & DDR Research Center 8th Joint International Symposium 2024  2025.2 

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    Event date： 2025.2

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：福岡   Country：Japan  

  • 味覚受容体の種特異的感受性のメカニズム

    實松　敬介、永里　侑貴、川端　由子, 髙井　信吾, 重村　憲徳

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date： 2024.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：長崎   Country：Japan  

  • 甘味受容体の動的活性化の分子機構

    @實松　敬介

    日本味と匂学会第58回大会  2024.9 

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    Event date： 2024.9

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：岡山   Country：Japan  

  • Molecular mechanisms of sweet taste receptor activation/inactivation and species-specific sensitivity Invited

    @Keisuke Sanematsu, #Masato Yamamoto, #Yuki Nagasato, @Yuko Kawabata, @Shingo Takai, @Noriatsu Shigemura

    第101回日本生理学会大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • 味覚受容機構のデジタル化における現状 Invited

    @實松　敬介

    第19回日本感性工学会春季大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：福岡   Country：Japan  

  • Elucidation for the activation/inactivation dynamics of the sweet taste receptor Invited

    @Keisuke Sanematsu, #Masato Yamamoto, #Yuki Nagasato, @Yuko Kawabata, @Shingo Takai, @Noriatsu Shigemura

    ISMNTOP2023  2023.11 

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    Event date： 2023.11

    Language：English   Presentation type：Oral presentation (general)  

    Venue：岡山   Country：Japan  

  • 甘味受容体サブユニットTAS1R3の活性化・不活性化メカニズムの解明

    @實松　敬介，@川端　由子, @渡邉　雄, @岩田　周介, @髙井　信吾, @重村　憲徳

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • サッカリンの種特異的感受性の分子メカニズム

    @實松　敬介、#永里　侑貴、#山本　真隆人、#平山 彩夏、#今村　恵美子、@川端　由子、@髙井　信吾、@重村　憲徳

    日本味と匂学会第57回大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • Elucidation of the dynamic function for the transmembrane domain of the sweet taste receptor subunit, TAS1R3

    @實松 敬介、#山本 真隆人、@川端 由子1、@渡邉 雄、@岩田 周介、@髙井 信吾、@重村 憲徳

    日本生理学会 第100回記念大会  2023.3 

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    Event date： 2023.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：国立京都国際会館（京都）   Country：Japan  

  • Visualization of taste Invited International conference

    @Keisuke Sanematsu

    22nd International Congress of Nutrition  2022.12 

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    Event date： 2022.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Tokyo International Forum (Tokyo)   Country：Japan  

  • 甘味受容体の動的活性化・不活性化メカニズム

    @實松　敬介、#山本　真隆人、@川端　由子、@岩田　周介、@髙井　信吾、@重村　憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • 甘味受容体の動的活性化・不活性化メカニズムの理解 Invited

    @實松　敬介

    感覚研究コンソーシアム：第一回 味覚ワーキンググループ  2021.5 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：WEB開催   Country：Japan  

  • 味覚受容体再構築系におけるCa2+イメージングを用いた受容体機能解析

    ＠實松 敬介,@重村 憲徳

    第62回歯科基礎医学会学術大会  2020.9 

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    Event date： 2020.9 - 2020.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • Molecular mechanism for the suppressing effect of low pH on the sweet receptor sensitivity

    @Keisuke Sanematsu, @Yuzo Ninomiya, @Noriatsu Shigemura

    第97回日本生理学会大会  2020.3 

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    Event date： 2020.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：大分   Country：Japan  

  • 抗不整脈薬フレカイニドがマウス味蕾オルガノイドおよび味行動応答に及ぼす影響

    ＃川端 由子,@髙井 信吾,＠吉田 竜介,＠實松 敬介,＠川端 二功,@重村 憲徳

    第61回歯科基礎医学会学術大会  2019.10 

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    Event date： 2019.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • 抗不整脈薬フレカイニドによるマウス味行動の変化

    ＃川端 由子,@髙井 信吾,＠吉田 竜介,＠實松 敬介,＠川端 二功,@重村 憲徳

    日本味と匂学会第53回大会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：高知   Country：Japan  

  • 低pH条件はサッカリンの甘味感受性を低下させる

    ＠實松 敬介,#尾崎 礼奈,#中林 開人,@重村 憲徳

    日本味と匂学会第53回大会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：高知   Country：Japan  

  • ヒト味覚認知閾値に対する低濃度塩添加の影響

    ＠吉田 竜介＠實松 敬介,@髙井 信吾,＠岩田 周介,@重村 憲徳

    日本味と匂学会第53回大会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：高知   Country：Japan  

  • Molecular mechanisms of suppressing and modifying effects on sweet taste receptor sensitivity Invited

    ＠Keisuke Sanematsu,@Yuzo Ninomiya,@Noriatsu Shigemura

    ECRO2019  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Trieste   Country：Italy  

  • 低pH条件下における甘味受容体感受性の解析

    ＠實松 敬介,#尾崎 礼奈,#中林 開人,@二ノ宮 裕三,@重村 憲徳

    日本味と匂学会第52回大会  2018.10 

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    Event date： 2018.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：埼玉   Country：Japan  

  • 甘味受容体のアゴニスト/アンタゴニスト特性 Invited

    ＠實松 敬介,@重村 憲徳,@二ノ宮 裕三

    第56回日本生物物理学会年会  2018.9 

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    Event date： 2018.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岡山   Country：Japan  

  • グルカゴン様ペプチド-１受容体遺伝子多型と甘味認知閾値との関連について

    ＠實松 敬介,@井上 真由子, @髙井 信吾,@二ノ宮 裕三

    第60回歯科基礎医学会学術大会  2018.9 

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    Event date： 2018.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 甘味受容体と甘味修飾物質との結合特性 Invited

    ＠實松 敬介

    日本味と匂学会第51回大会  2017.9 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：神戸   Country：Japan  

  • Intracellular acidification participates in full activation of the　sweet taste receptor in taste-modifying effect of miraculin

    實松 敬介, 北川 昌幸,重村 憲徳, 韮澤 悟, 二ノ宮 裕三

    第94回 日本生理学会大会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：浜松   Country：Japan  

  • 甘味受容体TAS1R2/TAS1R3におけるギムネマ酸の甘味抑制効果の分子メカニズム Invited

    實松 敬介, 重村 憲徳, 二ノ宮 裕三

    第5８回歯科基礎医学会学術大会  2016.8 

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    Event date： 2016.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • ミラクリンによる甘味誘導効果の分子メカニズム

    實松 敬介, 吉田 竜介, 重村 憲徳, 二ノ宮 裕三

    第5８回歯科基礎医学会学術大会  2016.8 

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    Event date： 2016.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：札幌   Country：Japan  

  • Intracellular acidification is involved in full activation of the sweet taste receptor by miraculin. International conference

    實松 敬介, 北川 昌幸, 吉田 竜介, 韮澤　悟, 重村 憲徳, 二ノ宮 裕三

    17th International Symposium on Olfaction and Taste  2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • 甘味受容体T1R2/T1R3に対する味覚修飾作用の解析

    實松 敬介, 重村 憲徳, 二ノ宮 裕三

    第57回歯科基礎医学会学術大会  2015.9 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：新潟   Country：Japan  

  • Glucuronosyl group of gymnemic acids mainly interacts with the transmembrane domain of human T1R3 in sweet-suppressing effect.

    實松 敬介, 日下部裕子, 重村 憲徳, 広川　貴次, 中村 誠司, 井元　敏明, 二ノ宮 裕三

    第120回 日本解剖学会総会･全国学術集会 第92回 日本生理学会大会　合同大会  2015.3 

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    Event date： 2015.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：神戸   Country：Japan  

  • The molecular mechanisms involved in taste modifying effect of gymnemic acids examined by sweet-sensor

    實松 敬介, 中野 (安松) 啓子, 重村 憲徳, 二ノ宮 裕三

    第48回知覚コロキウム 国際五感シンポジウム  2015.3 

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    Event date： 2015.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：日田   Country：Japan  

  • The effect of gymnemic acids on taste and the recovery by r-cyclodextrin

    中野 (安松) 啓子, 實松 敬介, 二ノ宮 裕三

    第48回知覚コロキウム 国際五感シンポジウム  2015.3 

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    Event date： 2015.3

    Language：Japanese  

    Venue：日田   Country：Japan  

  • 甘味受容体T1R2/T1R3の分子メカニズム

    實松 敬介

    細胞センサーの分子機構・相互関連・ネットワーク研究会  2014.12 

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    Event date： 2014.12

    Language：Japanese  

    Venue：岡崎   Country：Japan  

  • 甘味受容体機能の解析

    實松 敬介, 日下部裕子, 重村 憲徳, 広川　貴次, 井元　敏明, 二ノ宮 裕三

    日本味と匂学会第47回大会  2013.9 

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    Event date： 2013.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • 肥満者におけるレプチンおよび味覚日内変動の検索

    實松 敬介, 北川　昌幸, 中村　由紀, 野村 政壽, 重村 憲徳, 二ノ宮 裕三

    日本味と匂学会第46回大会  2012.10 

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    Event date： 2012.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：大阪   Country：Japan  

  • Lack of diurnal variation of sweet recognition thresholds in over-weight and obese humans. International conference

    實松 敬介, 北川　昌幸, 中村　由紀, 野村 政壽, 重村 憲徳, 二ノ宮 裕三

    ISOT XVI  2012.6 

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    Event date： 2012.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Stockholm   Country：Sweden  

  • Molecular mechanisms for sweet-suppressing effects of gymnemic acid and gurmarin Invited

    Sanematsu K, Ninomiya Y

    日本味と匂学会第45回大会  2011.10 

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    Event date： 2011.10

    Presentation type：Symposium, workshop panel (public)  

    Venue：金沢   Country：Japan  

  • 甘味受容体T1R2/T1R3に対する味覚修飾物質の相互作用部位の解析 Invited

    實松敬介、二ノ宮裕三

    第53回歯科基礎医学会学術大会・総会  2011.9 

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    Event date： 2011.9 - 2011.10

    Presentation type：Symposium, workshop panel (public)  

    Venue：岐阜   Country：Japan  

    Interaction site for taste modifiers at the sweet taste receptor T1R2/T1R3

  • 甘味抑制物質グルマリンの分子メカニズム

    實松敬介、二ノ宮裕三

    第34回日本神経科学大会  2011.9 

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    Event date： 2011.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

    Molecular mechanism of the sweet taste inhibitor: gurmarin

  • Molecular mechanisms between sweet receptors and taste modifiers International conference

    Sanematsu K, Ninomiya Y

    The International Chemical Congress of Pacific Basin Societies  2010.12 

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    Event date： 2010.12

    Presentation type：Symposium, workshop panel (public)  

    Venue：Honolulu   Country：United States  

  • Identification of the Gurmarin interaction site within the mouse sweet receptor International conference

    Sanematsu K, Ninomiya Y

    The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory  2010.11 

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    Event date： 2010.11

    Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • 甘味受容体T1R2/T1R3に対するグルマリン相互作用部位の同定

    實松敬介、二ノ宮裕三

    第52回歯科基礎医学会学術大会・総会  2010.9 

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    Event date： 2010.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：船堀   Country：Japan  

    Interaction site for grumarin at the sweet taste receptor T1R2/T1R3

  • グルマリンによる甘味抑制効果の分子メカニズム

    實松敬介、二ノ宮裕三

    味と匂学会第44回大会  2010.9 

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    Event date： 2010.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：北九州   Country：Japan  

    Molecular mechanism for sweet suppressing effect of grumarin

  • ギムネマ酸による甘味抑制効果の分子メカニズム

    實松敬介、重村憲徳、上瀧将史、中村誠司、井元敏明、二ノ宮裕三

    第87回日本生理学会大会  2010.5 

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    Event date： 2010.5

    Presentation type：Symposium, workshop panel (public)  

    Venue：盛岡   Country：Japan  

    Molecular mechanism for the sweet suppressing effect of gymnemic acid

  • Suppressing effect of cyclodextrin to taste modifiers International conference

    Sanematsu K, Nakamura S, Ninomiya Y

    32th Annual Meeting of the Association for Chemoreception Sciences  2010.4 

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    Event date： 2010.4

    Presentation type：Symposium, workshop panel (public)  

    Venue：ST. PETE BEACH   Country：United States  

  • 甘味抑制物質ギムネマ酸のヒト甘味受容体に対する相互作用部位

    實松敬介、重村憲徳、上瀧将史、中村誠司、井元敏明、二ノ宮裕三

    第６０回西日本生理学会  2009.11 

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    Event date： 2009.11

    Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • 甘味受容体T1R2/T1R3に対するギムネマ酸相互作用部位の同定

    實松敬介、重村憲徳、二ノ宮裕三

    第51回歯科基礎医学会学術大会  2009.9 

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    Event date： 2009.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：新潟   Country：Japan  

  • ヒトT1R2/T1R3に対するギムネマ酸の相互作用部位の同定

    實松敬介、重村憲徳、上瀧将史、中村誠司、井元敏明、二ノ宮裕三

    日本味と匂学会第43回大会  2009.9 

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    Event date： 2009.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：旭川   Country：Japan  

  • Identification of the Interaction site for Gymnemic acid at the sweet taste receptor T1R2+T1R3 International conference

    Sanematsu　K, Shigemura N, Jyotaki M, Nakamura S, Imoto T, Ninomiya Y

    31th Annual Meeting of the Association for Chemoreception Sciences  2009.4 

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    Event date： 2009.4

    Presentation type：Symposium, workshop panel (public)  

    Venue：Salasota   Country：United States  

  • Identification of the interaction sites for anti-sweet substances; Gymnemic acid and Gurmarin International conference

    Sanematsu K, Shigemura N, Jyotaki M, Nakamura S, Imoto T, Ninomiya Y

    The International Jyoint Symposium”Dental and Craniofacial Morphogenesis and Tissue Regeneration”　and "Oral Health Science"  2009.2 

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    Event date： 2009.2

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Identification of the interaction sites for Gymnemic acid and Gurmarin at the sweet taste receptor International conference

    Sanematsu K, Shigemura N, Jyotaki M, Nakamura S, Imoto T, Ninomiya Y

    The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory  2008.12 

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    Event date： 2008.12

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 甘味受容体T1R2/T1R3とトリテルペン配糖体の相互作用

    實松敬介、重村憲徳、二ノ宮裕三

    第50回歯科基礎医学会学術大会  2008.9 

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    Event date： 2008.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • トリテルペン配糖体とヒト甘味受容体hT1R2/hT1R3の相互作用

    實松敬介、重村憲徳、中村誠司、井元敏明、二ノ宮裕三

    日本味と匂学会第42回大会  2008.9 

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    Event date： 2008.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：富山   Country：Japan  

  • Interaction between triterpene glycoside and sweet taste receptor hT1R2+hT1R3

    Sanematsu K, Shigemura N, Imoto T, Ninomiya Y

    The 15th International Symposium on Olfaction and Taste/ The 30th Association for Chemoreception Sciences  2008.7 

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    Event date： 2008.7

    Presentation type：Symposium, workshop panel (public)  

    Venue：San Francisco   Country：United States  

  • hT1R2+hT1R3強制発現系を用いたギムネマ酸の甘味抑制効果解析

    實松敬介、重村憲徳、井元敏明、二ノ宮裕三

    第58回西日本生理学会  2007.10 

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    Event date： 2007.10

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 甘味およびうま味受容体機能解析

    實松敬介、重村憲徳、二ノ宮裕三

    第49回歯科基礎医学会学術大会  2007.8 

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    Event date： 2007.8

    Presentation type：Symposium, workshop panel (public)  

    Venue：北海道   Country：Japan  

  • 甘味受容体hT1R2+hT1R3強制発現系によるギムネマ酸の甘味抑制効果解析

    實松敬介、重村憲徳、井元敏明、二ノ宮裕三

    日本味と匂学会第41回大会  2007.7 

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    Event date： 2007.7

    Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • グルマリン感受性とTas1r3遺伝子多型の非関連性

    實松敬介、安松啓子、吉田竜介、重村憲徳、二ノ宮裕三

    第84回日本生理学会大会  2007.3 

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    Event date： 2007.3

    Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Tas1r3遺伝子型とグルマリン感受性における3種系統比較

    實松敬介、安松啓子、吉田竜介、重村憲徳、二ノ宮裕三

    第48回歯科基礎医学会  2006.9 

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    Event date： 2006.9

    Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Tas1r3遺伝子型とグルマリン感受性の相関

    實松敬介、安松啓子、吉田竜介、重村憲徳、二ノ宮裕三

    日本味と匂学会第40回大会  2006.7 

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    Event date： 2006.7

    Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • Diurnal variation of plasma leptin levels and taste recognition thresholds in over-weight and obese subjects. International conference

    實松 敬介, 北川　昌幸, 中村　由紀, 野村 政壽, 重村 憲徳, 二ノ宮 裕三

    AChemS 2012  2012.4 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Huntington Beach   Country：United States  

  • 甘味受容細胞の感受性抑制機構 Invited

    實松 敬介, 二ノ宮 裕三

    病態生理学会  2012.8 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：大分   Country：Japan  

  • GPRC5C on pancreatic α-cells may contribute to the blood glucose regulation Invited

    Shingo Takai, Yuko Kawabata, Keisuke Sanematsu, Yusaku Iwasaki, Fuminari Kawabata, Noriatsu Shigemura

    ISMNTOP2024  2025.3 

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    Event date： 2025.3

    Language：English   Presentation type：Poster presentation  

    Venue：岡山   Country：Japan  

  • Computational analysis of sodium ion permeation mechanisms in capsaicin receptor, transient receptor potential vanilloid 1 Invited

    Yuki Nagasato, Keisuke Sanematsu, Emiko Imamura, Yuko Kawabata, Shingo Takai, Toshiro Matsui, Noriatsu Shigemura

    ISMNTOP2024  2025.3 

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    Event date： 2025.3

    Language：English   Presentation type：Poster presentation  

    Venue：岡山   Country：Japan  

  • オーファンGPCR であるGPRC5C の応答特性と動物の糖代謝への影響

    高井　信吾、川端　由子、實松　敬介、重村　憲徳

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date： 2024.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：長崎   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスにおける味覚嗜好性の変容

    川端　由子、高井　信吾、岩田　周介、實松　敬介、兼松　隆、自見　英治郎、重村　憲徳

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date： 2024.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：長崎   Country：Japan  

  • 温度感受性TRPV1 におけるナトリウムイオン透過機構の in silico 解析

    永里　侑貴、實松　敬介、川端　由子、高井　信吾、重村　憲徳

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date： 2024.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：長崎   Country：Japan  

  • カプサイシン受容体TRPV1におけるナトリウムイオン透過機構の解明

    永里　侑貴、實松　敬介、今村　恵美子、川端　由子、髙井　信吾、松井　利朗、重村　憲徳

    日本味と匂学会第58回大会  2024.9 

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    Event date： 2024.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：岡山   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスにおける味覚嗜好性変化の解析

    川端　由子、髙井　信吾、岩田　周介、實松　敬介、川端　二功、重村　憲徳

    日本味と匂学会第58回大会  2024.9 

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    Event date： 2024.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：岡山   Country：Japan  

  • GPRC5Cの応答特性と血糖値調節機構への影響の検討

    髙井　信吾、川端　由子、實松　敬介、川端　二功、重村　憲徳

    日本味と匂学会第58回大会  2024.9 

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    Event date： 2024.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：岡山   Country：Japan  

  • マウスにおけるGPRC5Cの発現とリガンドの探索

    @髙井　信吾、@川端　由子、@實松　敬介、@岩田　周介、@川端　二功、@兼松　隆、@自見　英治郎、@重村　憲徳

    第101回日本生理学会大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北九州   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスにおける金属味感受性の変化

    @川端 由子,@髙井 信吾,@岩田 周介,@實松 敬介,@兼松 隆,@自見 英治郎,@重村 憲德

    第101回日本生理学会大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北九州   Country：Japan  

  • GPRC5ファミリーによる糖受容機構の探索

    @高井 信吾、@川端 由子、@實松 敬介、@岩田 周介、@兼松 隆、@自見 英治郎、@重村 憲德

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスの味覚変調とその分子機構の解析

    @川端 由子、@髙井 信吾、@岩田 周介、@實松 敬介、@兼松 隆、@自見 英治郎、@重村 憲德

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • GPRC5 family の発現と機能の探索

    @高井 信吾、@川端 由子、@實松 敬介、@岩田 周介、@川端 二功、@重村 憲徳

    日本味と匂学会第57回大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスにおける味覚変調の分子機構

    @川端 由子、@高井 信吾、@岩田 周介、@實松 敬介、@川端 二功、@重村 憲徳

    日本味と匂学会第57回大会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • 味蕾の基底細胞は mTOR シグナリングを介して体内栄養状態をモニターする

    @高井 信吾、@岩田 周介、@實松 敬介、@川端 由子、#平山 彩夏、@渡邉 雄、@重村 憲徳

    第64回歯科基礎医学会学術大会  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：徳島   Country：Japan  

  • カプサイシンのマウス味覚神経応答に対する影響

    @岩田 周介、@吉田 竜介、@高井 信吾、@實松 敬介、@重村 憲徳、@二ノ宮裕三

    第64回歯科基礎医学会学術大会  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：徳島   Country：Japan  

  • 経後骨粗鬆症モデルマウスの味覚行動の変化

    @川端 由子、#尾池 麻未、@高井 信吾、@岩田 周介、@實松 敬介、@重村 憲徳、@兼松 隆、@自見英治郎

    第64回歯科基礎医学会学術大会  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：徳島   Country：Japan  

  • 閉経後骨粗鬆症モデルマウスの味覚感受性

    @川端由子、#尾池麻未、@高井信吾、@岩田周介、@實松敬介、@川端二功、@重村憲徳

    日本味と匂学会第56回大会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • 嗅覚機能と味覚機能との関連ー岩木健康増進プロジェクトの結果から-

    @山内一崇、@松下大佑、@清水目奈美、@工藤玲子、@小濱祐介、@川端二功、@川端由子、@實松敬介、@高井信吾、@山添淳一、@重村憲徳、@後藤真一、@佐々木亮、@松原篤

    日本味と匂学会第56回大会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • カプサイシンがマウス鼓索神経応答に及ぼす影響

    @岩田周介、@吉田竜介、@高井信吾、@實松敬介、@重村憲徳、@二ノ宮裕三

    日本味と匂学会第56回大会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • mTORシグナリングを介した味蕾の体内栄養感知機構

    @高井信吾、@岩田周介、@實松敬介、#大野友里花、#平山彩夏、#尾池麻未、@重村憲徳

    日本味と匂学会第56回大会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • ビスホスホネート長期投与による酸味溶液に対する忌避性行動の増強

    #尾池麻未、@岩田周介、#平山彩夏、#大野友里花、#永里侑貴、@川端由子、@高井信吾、@實松敬介、@和田尚久、@重村憲徳

    日本味と匂学会第56回大会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • ナトリウム利尿ペプチドが塩味の行動応答に及ぼす影響

    #菅原 友佳, @高井 信吾, @川端 由子, @岩田 周介, @渡邉 雄, #尾池 麻未, #平山 彩夏, @實松 敬介, @田畑 正志, @重村 憲徳

    日本農芸化学会2022年度大会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都   Country：Japan  

  • アドレノメデュリンによるマウス鼓索神経甘味応答増強機構の解明

    @岩田 周介，吉田 竜介，@高井 信吾，@實松 敬介，@重村 憲徳，二ノ宮裕三

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 抗不整脈薬フレカイニドの酸味増強作用とその分子機構の解析

    @川端 由子，@高井 信吾，吉田 竜介，@實松 敬介，@重村 憲徳

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 非ステロイド性抗炎症薬長期投与によるマウス甘味・うま味感受性の抑制

    #平山 彩夏，@岩田 周介，#尾池 麻未，@渡邉 雄，@川端 由子，@實松 敬介，@高井 信吾，@高橋 一郎， @重村 憲徳

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 体内の栄養状態を反映したマウス味細胞におけるmechanistic target of rapamycin(mTOR)活性化

    @高井 信吾，@岩田 周介，@實松 敬介，@重村 憲徳

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 不整脈薬フレカイニドはマウスの酸味応答性を増強する

    @川端 由子，@高井 信吾，吉田 竜介，@實松 敬介，川端 二功，@重村 憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • マウス味蕾における mechanistic target of rapamycin(mTOR)の機能探索

    @高井 信吾，@岩田 周介，@實松 敬介，@重村 憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • ビスホスホネート製剤由来味覚障害の分子機構の解明

    #尾池 麻未，@岩田 周介，#平山 彩夏，#菅原 友佳，#大野 友里花，@川端 由子，@高井 信吾，@實松 敬介，@和田 尚久，@重村 憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • Adrenomedullin enhances mouse chorda tympani nerve responses to sugars via T1R-independent mechanisms

    @岩田周介，吉田竜介，@高井信吾，@實松敬介，@重村憲徳，二ノ宮裕三

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • ナトリウム利尿ペプチドによる塩味感受性調節機構

    #菅原 友佳，@高井 信吾，@川端 由子，@岩田 周介，@渡邉 雄，@尾池 麻未，#平山 彩夏，@實松 敬介，@田畑 正志，@重村 憲徳

    日本味と匂学会第55回大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • Gene expression profiling of Gustducin-expressing cells in mouse fungiform papillae and circumvallate papillae

    #山田 優、@高井 信吾、#渡邉 雄、#尾崎 礼奈、@川端 由子、#尾池 麻未、#平山 彩夏、@岩田 周介、@實松 敬介、@西村 正太郎、@田畑 正 志、@重村 憲徳

    第98回日本生理学会大会  2021.3 

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    Event date： 2021.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 食事への興味・食習慣が味覚閾値に及ぼす影響について

    小濱 佑介、#川端 由子、宮崎 明子、田口 大夢、川端 二功、松原 篤、工藤 玲子、清水目 奈美、@重村 憲徳、@實松 敬介、@高井 信吾、@山 添 淳一、平尾 宜司、上野 正一、村下 公一、安藤 雅峻、沢田 かほり、井原 一成、山本 佳弘、中路 重之

    日本味と匂学会第54回大会  2020.10 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • 茸状乳頭および有郭乳頭におけるGustducin発現細胞のSingle cell RNA-Seq解析

    #山田 優、@高井 信吾、#渡邉 雄、#尾崎 礼奈、@川端 由子、#尾池 麻未、#平山 彩夏、@岩田 周介、@實松 敬介、@西村 正太郎、@田畑 正 志、@重村 憲徳

    日本味と匂学会第54回大会  2020.10 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB開催   Country：Japan  

  • The effects of flecainide on taste bud organoid growth and behavioral sour taste response in mice.

    #Yuko Kawabata,@Shingo Takai,@Ryusuke Yoshida,＠Keisuke Sanematsu,@Kawabata Fuminori,@Noriatsu Shigemura

    ISOT2020  2020.8 

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    Event date： 2020.8

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：WEB   Country：United States  

  • Gustatory responses of taste receptor cells expressing fluorescent proteins in transgenic mice. International conference

    Ryusuke Yoshida, Keiko Nakano (Yasumatsu), Keisuke Sanematsu, 重村　憲徳, Yuzo Ninomiya

    17th International Symposium on Olfaction and Taste  2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • 腸管内分泌細胞の味覚感受性に対するレプチンの効果

    上瀧　将史, 實松 敬介, 重村 憲徳, 二ノ宮 裕三

    第64回西日本生理学会  2013.10 

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    Event date： 2013.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北九州   Country：Japan  

  • 腸管内分泌細胞の味覚感受性に対するカンナビノイドの効果

    上瀧　将史, 實松 敬介, 重村 憲徳, 二ノ宮 裕三

    日本味と匂学会第46回大会、  2012.10 

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    Event date： 2012.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：大阪   Country：Japan  

  • 下唇に生じた粘表皮癌の１例

    實松敬介、大部一成、川野真太郎、石橋浩晃、中村誠司

    第60回日本口腔科学会総会  2006.5 

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    Event date： 2009.5 - 2006.5

    Presentation type：Symposium, workshop panel (public)  

    Venue：名古屋   Country：Japan  

  • Genitic and Molecular Basis of Indivisual Differences in human Umami Taste Perception International conference

    Shigemura N, Shirosaki S, Sanematsu K, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y

    31th Annual Meeting of the Association for Chemoreception Sciences  2009.4 

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    Event date： 2009.4

    Presentation type：Symposium, workshop panel (public)  

    Venue：Salasota   Country：United States  

  • Relationship between individual differences in umami taste sensitivity and genetic variations of T1r1 and T1r3 in human International conference

    Shigemura N, Shirosaki S, Sanematsu K, Shahidal AA Islam, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y

    The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory  2008.12 

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    Event date： 2008.12

    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • ヒトうま味感受性の多様性とうま味受容体遺伝子多型性との相関

    重村憲徳、イスラムアブ、城崎慎也、實松敬介、荻原葉子、河合美佐子、吉田竜介、二ノ宮裕三

    日本味と匂学会第42回大会  2008.9 

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    Event date： 2008.9

    Presentation type：Symposium, workshop panel (public)  

    Venue：富山   Country：Japan  

  • ヒトうま味感受性の多様性とT1r遺伝子多型性の相関

    重村憲徳、イスラムアブ、城崎慎也、實松敬介、荻原葉子、河合美佐子、吉田竜介、二ノ宮　裕三

    第85回日本生理学会大会  2008.3 

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    Event date： 2008.3

    Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • Transmission of taste information from receptor cells with action potentials to gustatory nerve fibers International conference

    Murata Y, Yoshida R, Yasumatsu K, Shirosaki S, Kawato Y, Nakao K, Ohkuri T, Sanematsu K, Yasuo T, Jyotaki M, Shigemura N, Damak S, Margolskee RF, Ninomiya Y

    The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory  2007.11 

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    Event date： 2007.11

    Venue：福岡   Country：Japan  

  • Taste receptor cells responding with action potentials to taste stimuli and their molecular expression of taste related genes International conference

    Yoshida R, Sanematsu K, Ninomiya Y

    ISOT/JASTS 2004  2004.7 

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    Event date： 2004.7

    Presentation type：Symposium, workshop panel (public)  

    Venue：京都   Country：Japan  

  • Response of taste clls with generating action potentials and exression of mRNA of synaptic and taste specific molecules detected by single cell RT-PCR method International conference

    Yoshida R, Shigemura N, Sanematsu K, Ninomiya Y

    The 2nd International Workshop on Molecular and Neural Mechanisms of Taste Perception  2003.12 

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    Event date： 2003.12

    Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • Otopetrin-1を介した抗不整脈薬フレカイニドの酸味増強作用

    川端 由子, 高井 信吾, 吉田 竜介, 實松 敬介, 川端 二功, 重村 憲徳

    日本栄養・食糧学会大会講演要旨集  2022.5  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • TRPV1のナトリウムイオン透過メカニズムの解明(Probing the mechanism of sodium ion permeation in TRPV1)

    Nagasato Yuki, Sanematsu Keisuke, Yamamoto Masato, Hirayama Ayaka, Imamura Emiko, Kawabata Yuko, Takai Shingo, Toshirou Matsui, Shigemura Noriatsu

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English  

  • おいしさの謎に迫る　食を解き明かす神経生理学的アプローチ　甘味受容体の活性化・不活性化および種特異的感受性の分子メカニズムの解明(The Mystery of Deliciousness: Unraveling the Secrets of Eating through Neurophysiological Approaches　Molecular mechanisms of sweet taste receptor activation/inactivation and species-specific sensitivity)

    Sanematsu Keisuke, Nagasato Yuki, Yamamoto Masato, Kawabata Yuko, Takai Shingo, Shigemura Noriatsu

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English  

  • 味覚情報伝達の分子・神経機構　甘味受容体の種特異的感受性のメカニズム

    實松 敬介, 永里 侑貴, 川端 由子, 高井 信吾, 重村 憲徳

    Journal of Oral Biosciences Supplement  2024.11  (一社)歯科基礎医学会

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    Language：Japanese  

  • 甘味受容体サブユニットTAS1R3の膜貫通ドメインにおける動的機能の解明(Elucidation of the dynamic function for the transmembrane domain of the sweet taste receptor subunit, TAS1R3)

    Sanematsu Keisuke, Yamamoto Masato, Kawabata Yuko, Watanabe Yu, Iwata Shusuke, Takai Shingo, Shigemura Noriatsu

    The Journal of Physiological Sciences  2023.5  (一社)日本生理学会

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    Language：English  

  • 糖類センサーとしてのGPRC5Cの機能分析(The functional analysis of GPRC5C as a saccharide sensor)

    Takai Shingo, Kawabata Yuko, Sanematsu Keisuke, Iwata Syusuke, Kawabata Fuminori, Kanematsu Takashi, Jimi Eijiro, Shigemura Noriatsu

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English  

  • 閉経後骨粗鬆症モデルマウスにおける金属味感受性の変化(Modification of metallic taste in postmenopausal osteoporosis model mice)

    Kawabata Yuko, Takai Shingo, Iwata Shusuke, Sanematsu Keisuke, Kawabata Fuminori, Kanematsu Takashi, Jimi Eijiro, Shigemura Noriatsu

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English  

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MISC

  • 甘味受容体と甘味修飾物質との結合特性

    @實松　敬介

    日本味と匂学会誌   2018.4

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • The behavioral taste responses of postmenopausal osteoporosis in mice

    川端由子, 川端由子, 尾池麻未, 高井信吾, 岩田周介, 實松敬介, 實松敬介, 重村憲徳, 重村憲徳, 兼松隆, 自見英治郎, 自見英治郎

    Journal of Oral Biosciences Supplement (Web)   2022   2022   （ ISSN:2187-9109 ）

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Professional Memberships

  • 日本生理学会

  • 歯科基礎医学会

  • AChemS

  • 日本神経科学学会

  • 日本味と匂学会

Committee Memberships

  • 日本味と匂学会   学術広報委員   Domestic

    2024.4 - 2027.3   

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    Committee type：Academic society

  • 日本味と匂学会   編集委員   Domestic

    2024.1 - 2027.1   

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    Committee type：Academic society

  • 日本味と匂学会若手の会   Steering committee member   Domestic

    2013.4 - 2015.3   

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    Committee type：Academic society

  • 日本味と匂学会   Councilor   Domestic

    2012.4 - Present   

Academic Activities

  • 座長 International contribution

    Role(s)： Panel moderator, session chair, etc.

    The 21st International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  （ Japan ） 2025.3

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    Type：Competition, symposium, etc. 

    Number of participants：140

  • シンポジウムオーガナイザー、座長

    Role(s)： Panel moderator, session chair, etc.

    第66回歯科基礎医学会学術大会   （ Japan ） 2024.11

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    Type：Competition, symposium, etc. 

    Number of participants：1,000

  • シンポジウムオーガナイザー、座長 International contribution

    Role(s)： Panel moderator, session chair, etc.

    日本味と匂学会第58回大会　  （ Japan ） 2024.9

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    Type：Competition, symposium, etc. 

    Number of participants：400

  • 準備委員 International contribution

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    KOB (Kyudai Oral Biosciences)・OBT・DDR 合同国際シンポジウム   （ Japan ） 2022.10

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：150

  • 準備委員 International contribution

    日本味と匂学会第55回大会　  （ Japan ） 2021.9

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：400

  • シンポジウムオーガナイザー、座長、準備委員 International contribution

    Role(s)： Planning, management, etc.,　Panel moderator, session chair, etc.

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2021  （ Japan ） 2021.2

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：150

  • 準備委員 International contribution

    Role(s)： Planning, management, etc.

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2020  （ Japan ） 2020.2

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：150

  • 準備委員 International contribution

    Role(s)： Planning, management, etc.

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019  （ Japan ） 2019.3

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：150

  • 準備委員

    第60回歯科基礎医学会学術大会  （ Japan ） 2018.9

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：1,000

  • 実行委員 International contribution

    International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  （ Japan ） 2013.10 - 2013.11

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：140

  • 実行委員 International contribution

    International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  （ Japan ） 2012.11

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：160

  • 実行委員 International contribution

    International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  （ Japan ） 2011.11

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：180

  • 実行委員 International contribution

    International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  （ Japan ） 2010.11

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：130

▼display all

Research Projects

  • Establishment of regulatory basis for nutrition and biological defense using taste receptors

    Grant number：24K02883  2024 - 2027

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    實松 敬介, 高井 信吾, 重村 憲徳, 川端 由子

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    味覚受容体は、口腔のみならず全身の様々な臓器に発現し、体内のエネルギーおよび化学受容センサーとして生体恒常性の維持や生体防御に寄与する可能性が示唆される。これらのシステムの破綻は、生活習慣病やがんなどの病態と関連する可能性があり、その基礎として、味覚受容体とリガンドとの結合特性およびその活性化機構を解明することが必要不可欠である。本研究では、全身に発現する味覚受容体を介した栄養および生体防御のメカニズムの解明からその制御を目指す。

    CiNii Research

  • 味覚障害と口腔内疾患とを結ぶ味覚-免疫連関機序の解明とその応用戦略

    Grant number：25K03068  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    重村 憲徳, 實松 敬介, 高井 信吾, 川端 由子

    　 More details

    Grant type：Scientific research funding

    新規概念「味覚-免疫連関」を様々な手法を用いて解明することを目的とする。
    ① マウスをもちいて味蕾オルガノイドを作成し、病原因子添加/非添加群との間で形態変化や分子発現の差、とりわけ分泌成分に違いがあるかどうか調べる。
    ② 候補受容体遺伝子をHEK293培養細胞に強制発現させ、病原因子投与時の細胞Ca2+応答を解析することにより病原因子の受容体を同定する。同時に、in silico分子動力学解析を進める。
    ③ 病原因子をWTマウスに投与し、その生体変化について行動・味神経・遺伝子の各レベルで解析する。最後に、歯周病菌または癌細細胞をWTと味覚障害マウスの口腔内（舌）へ接種し、味覚-免疫を実証する。

  • The Nature of Sweetness Receptor Mechanisms in Humans

    Grant number：24K08760  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    日下部 裕子, 安松 啓子, 實松 敬介

    　 More details

    Grant type：Scientific research funding

    甘味は快をもたらし嗜好性の高い食に欠かせない。甘味の主な役割は、エネルギー源としての糖を感知することと考えられがちだが、古代からノンシュガーの甘味を摂食してきた歴史から、甘味の生物学的意義をもう一度見直す必要がある。本研究では、申請者らが新たに見出した親油性で甘い化合物について、分子レベルから脳における知覚の観点において受容および認知機構を明らかにして甘味の意義を解明することを目的とする。

    CiNii Research

  • 健診Big Dataを基盤とした味覚健康医療の創発

    Grant number：22K19672  2022.6 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    重村 憲徳, 實松 敬介, 高井 信吾, 岩田 周介

    　 More details

    Grant type：Scientific research funding

    味覚の異常は、口腔のみならず全身の臓器でも生じ、摂食嚥下障害や生活習慣病の発症原因となる可能性が示唆されている。しかし、この味覚異常発症の分子機構はほとんど不明である。そこで本研究では、この「真の原因」を明らかにするために大規模健診における味覚検査データと、それと紐付けされた約2000項目の健康Big Dataとの多元的な相関解析を行うことにより味覚異常の原因因子を追求することに挑戦する。

    CiNii Research

  • Dynamic Interaction Mechanisms of Taste Receptors

    Grant number：21K09818  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Sanematsu Keisuke

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    The molecular mechanisms of dynamic receptor activation and inactivation that occur after the binding of taste molecules to their receptors have remained unknown because the analysis of the interaction between taste substances and taste receptors has focused on the static binding form. In this study, by introducing molecular dynamics simulations, we succeeded in reproducing the species-specific sensitivity of the sweet inhibitors gymnemic acid and lactisole and the artificial sweetener cyclamate in the transmembrane domain of the sweet taste receptor subunit TAS1R3. In particular, cyclamate was found to act as an artificial sweetener in the human receptor and as an inhibitor in the mouse receptor.

    CiNii Research

  • Elucidation of molecular basis of the onset of taste disorder based on pharmaco-genomics

    Grant number：19H03818  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Shigemura Noriatsu

    　 More details

    Grant type：Scientific research funding

    Taste disorders present with symptoms such as "no taste, always bitter," and significantly reduces not only quality of life but also nutritional status. However, its pathogenesis is largely unknown. The purpose of this study was to elucidate the molecular basis of taste disorders through the use of　pharmacological action of various drugs. In this study, we developed mouse models with taste disorder induced by administration of anticancer drugs, osteoporosis drug bisphosphonate, antiarrhythmic drug flecainide and antipyretic analgesic diclofenac. Using molecular biological, neurological and behavioral analyses, and taste bud organoid technology, we clarified the molecular mechanism of the onset of each taste disorders. These results would be expected to lead to the development of novel preventive and therapeutic methods for taste disorders.

    CiNii Research

  • 全身に発現する味覚受容体の分子・生理・病態機能の解明

    Grant number：18K09523  2018 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 平成29年度がん研究助成金優秀賞

    2017

    　 More details

    Grant type：Donation

  • エネルギー受容センサーとしての甘味受容体解析

    Grant number：15K11045  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 甘味受容体機能の解明

    Grant number：25861759  2013 - 2014

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 甘味受容体と味覚修飾物質の相互作用解析

    Grant number：23792128  2011 - 2012

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 口腔消化管味覚センサーのシグナル調節・伝達機構の解明

    Grant number：23249081  2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 食の調節情報としての味覚の受容・機序の解明：味覚健康科学の創成

    Grant number：18109013  2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

▼display all

Class subject

  • 口腔機能解析学（低年次）　D

    2025.12 - 2026.2   Winter quarter

  • 口腔機能解析学（コア）　D

    2025.12 - 2026.2   Winter quarter

  • リサーチエクスポージャ3

    2025.12 - 2026.2   Winter quarter

  • 口腔生理学４

    2025.12 - 2026.2   Winter quarter

  • 口腔機能解析学（低年次）　C

    2025.10 - 2025.12   Fall quarter

  • 口腔機能解析学（コア）　C

    2025.10 - 2025.12   Fall quarter

  • リサーチエクスポージャ2

    2025.10 - 2025.12   Fall quarter

  • 口腔生理学３

    2025.10 - 2025.12   Fall quarter

  • 歯学総論７

    2025.9 - 2025.10   Fall quarter

  • 口腔機能解析学（低年次）　B

    2025.6 - 2025.8   Summer quarter

  • 口腔機能解析学（コア）　B

    2025.6 - 2025.8   Summer quarter

  • リサーチエクスポージャ1

    2025.6 - 2025.8   Summer quarter

  • 口腔生理学２

    2025.6 - 2025.8   Summer quarter

  • 口腔機能解析学（応用編）

    2025.4 - 2026.3   Full year

  • 口腔機能解析学（基礎編）

    2025.4 - 2026.3   Full year

  • 口腔機能解析学（低年次）　A

    2025.4 - 2025.6   Spring quarter

  • 口腔機能解析学（コア）　A

    2025.4 - 2025.6   Spring quarter

  • リサーチエクスポージャ4

    2025.4 - 2025.6   Spring quarter

  • アーリーエクスポージャ

    2025.4 - 2025.6   Spring quarter

  • 口腔生理学１

    2025.4 - 2025.6   Spring quarter

  • 口腔機能解析学（コア）　D

    2024.12 - 2025.2   Winter quarter

  • 口腔生理学４

    2024.12 - 2025.2   Winter quarter

  • リサーチエクスポージャ3

    2024.12 - 2025.2   Winter quarter

  • 口腔機能解析学（低年次）　D

    2024.12 - 2025.2   Winter quarter

  • 口腔機能解析学（コア）　C

    2024.10 - 2024.12   Fall quarter

  • 口腔生理学３

    2024.10 - 2024.12   Fall quarter

  • リサーチエクスポージャ2

    2024.10 - 2024.12   Fall quarter

  • 口腔機能解析学（低年次）　C

    2024.10 - 2024.12   Fall quarter

  • 歯学総論７

    2024.10 - 2024.11   Fall quarter

  • 口腔機能解析学（コア）　B

    2024.6 - 2024.8   Summer quarter

  • 口腔生理学２

    2024.6 - 2024.8   Summer quarter

  • リサーチエクスポージャ1

    2024.6 - 2024.8   Summer quarter

  • 口腔機能解析学（低年次）　B

    2024.6 - 2024.8   Summer quarter

  • 口腔機能解析学（基礎編）

    2024.4 - 2025.3   Full year

  • 口腔機能解析学（応用編）

    2024.4 - 2025.3   Full year

  • 口腔機能解析学（コア）　A

    2024.4 - 2024.6   Spring quarter

  • 口腔生理学１

    2024.4 - 2024.6   Spring quarter

  • リサーチエクスポージャ4

    2024.4 - 2024.6   Spring quarter

  • アーリーエクスポージャ

    2024.4 - 2024.6   Spring quarter

  • 口腔機能解析学（低年次）　A

    2024.4 - 2024.6   Spring quarter

  • リサーチエクスポージャ3

    2023.12 - 2024.2   Winter quarter

  • 口腔生理学

    2023.12 - 2024.2   Winter quarter

  • リサーチエクスポージャ2

    2023.10 - 2023.12   Fall quarter

  • 口腔生理学

    2023.10 - 2023.12   Fall quarter

  • リサーチエクスポージャ1

    2023.6 - 2023.8   Summer quarter

  • 口腔生理学

    2023.6 - 2023.8   Summer quarter

  • アーリーエクスポージャ

    2023.4 - 2023.6   Spring quarter

  • 口腔生理学

    2023.4 - 2023.6   Spring quarter

  • リサーチエクスポージャ4

    2023.4 - 2023.6   Spring quarter

  • リサーチエクスポージャ3

    2022.12 - 2023.2   Winter quarter

  • リサーチエクスポージャ2

    2022.10 - 2022.12   Fall quarter

  • リサーチエクスポージャ1

    2022.6 - 2022.8   Summer quarter

  • 口腔生理学

    2022.4 - 2023.3   Full year

  • 電気生理学実験法（大学院）

    2022.4 - 2023.3   Full year

  • 口腔機能解析学

    2022.4 - 2023.3   Full year

  • 口腔機能解析学演習

    2022.4 - 2023.3   Full year

  • リサーチエクスポージャ4

    2022.4 - 2022.6   Spring quarter

  • アーリーエクスポージャ

    2022.4 - 2022.6   Spring quarter

  • リサーチエクスポージャ1

    2021.4 - 2022.3   Full year

  • 口腔生理学

    2021.4 - 2022.3   Full year

  • 電気生理学実験法（大学院）

    2021.4 - 2022.3   Full year

  • 口腔機能解析学

    2021.4 - 2022.3   Full year

  • 口腔機能解析学演習

    2021.4 - 2022.3   Full year

  • アーリーエクスポージャ

    2021.4 - 2021.9   First semester

  • リサーチエクスポージャ

    2021.4 - 2021.9   First semester

  • 口腔生理学

    2020.4 - 2021.3   Full year

  • リサーチエクスポージャ1

    2020.4 - 2021.3   Full year

  • 電気生理学実験法（大学院）

    2020.4 - 2021.3   Full year

  • 口腔機能解析学

    2020.4 - 2021.3   Full year

  • 口腔機能解析学演習

    2020.4 - 2021.3   Full year

  • リサーチエクスポージャ

    2020.4 - 2020.9   First semester

  • アーリーエクスポージャ

    2020.4 - 2020.9   First semester

  • 口腔生理学

    2019.4 - 2020.3   Full year

  • 口腔常態制御学特論

    2019.4 - 2020.3   Full year

  • Oral Physiology and Taste Health Science

    2019.4 - 2020.3   Full year

  • 5年リサーチエクスポージャー

    2019.4 - 2019.9   First semester

  • 4年アーリーエクスポージャー

    2019.4 - 2019.9   First semester

  • 6年リサーチエクスポージャー

    2018.10 - 2019.3   Second semester

  • 口腔生理学

    2018.4 - 2019.3   Full year

  • 4年リサーチエクスポージャー

    2018.4 - 2019.3   Full year

  • 口腔機能解析学

    2018.4 - 2019.3   Full year

  • Oral Physiology and Taste Health Science

    2018.4 - 2019.3   Full year

  • 4年アーリーエクスポージャー

    2018.4 - 2018.9   First semester

  • 5年リサーチエクスポージャー

    2018.4 - 2018.9   First semester

  • 口腔生理学

    2017.4 - 2018.3   Full year

  • Oral Physiology and Taste Health Science

    2017.4 - 2018.3   Full year

  • 口腔機能解析学

    2017.4 - 2018.3   Full year

  • 4年リサーチエクスポージャー

    2017.4 - 2018.3   Full year

  • 4年アーリーエクスポージャー

    2017.4 - 2017.9   First semester

  • 口腔生理学

    2016.4 - 2017.3   Full year

  • Oral Physiology and Taste Health Science

    2016.4 - 2017.3   Full year

  • 口腔機能解析学

    2016.4 - 2017.3   Full year

  • 口腔生理学

    2015.4 - 2016.3   Full year

  • 口腔機能解析学

    2015.4 - 2016.3   Full year

  • Oral Physiology and Taste Health Science

    2015.4 - 2016.3   Full year

  • 3年リサーチエクスポージャー

    2015.4 - 2015.9   First semester

  • 口腔生理学

    2014.4 - 2015.3   Full year

  • 3年リサーチエクスポージャー

    2014.4 - 2014.9   First semester

  • 歯学総論Ⅰ

    2013.4 - 2014.3   Full year

  • 口腔生理学

    2013.4 - 2014.3   Full year

  • 3年リサーチエクスポージャー

    2013.4 - 2013.9   First semester

  • 口腔生理学

    2012.4 - 2013.3   Full year

  • 歯学総論Ⅰ

    2012.4 - 2013.3   Full year

  • 3年リサーチエクスポージャー

    2012.4 - 2012.9   First semester

  • 歯学総論Ⅰ

    2011.4 - 2012.3   Full year

  • 口腔生理学

    2011.4 - 2012.3   Full year

  • 3年リサーチエクスポージャー

    2011.4 - 2011.9   First semester

  • 歯学総論Ⅰ

    2010.4 - 2011.3   Full year

  • 口腔生理学

    2010.4 - 2011.3   Full year

  • 3年リサーチエクスポージャー

    2010.4 - 2010.9   First semester

  • 3年リサーチエクスポージャー

    2009.4 - 2009.9   First semester

▼display all

FD Participation

  • 2025.6   Role：Participation   Title：WHO口腔保健プログラムでの仕事：ユニバーサルヘルスカバレッジ達成に向けて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2024.6   Role：Participation   Title：歯科医師国家試験合格率アップのための戦略

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2024.6   Role：Participation   Title：入学者選抜における面接試験～位置付けと評価方法について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.6   Role：Participation   Title：科学研究費補助金採択率向上に向けた工夫

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.7   Role：Participation   Title：科研費申請書ー採択に近づく書き方のコツ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.7   Role：Participation   Title：廃棄物の分別等について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.4   Role：Participation   Title：CBT問題作問講習会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.10   Role：Participation   Title：令和２年度馬出地区４部局合同男女共同参画FD

    Organizer：University-wide

  • 2020.6   Role：Participation   Title：電子ジャーナルをめぐる現状と今後に向けた対応について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.10   Role：Participation   Title：令和元年度馬出地区４部局合同男女共同参画FD

    Organizer：University-wide

  • 2018.10   Role：Participation   Title：平成３０年度 馬出地区４部局合同男女共同参画FD

    Organizer：University-wide

  • 2018.8   Role：Participation   Title：歯学研究院の研究力分析と研究力強化に向けたScopus/Scival/Pure活用例、BIツールを用いた研究力分析の紹介

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.5   Role：Participation   Title：臨床実習後臨床能力試験トライアルの実施に向けて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.3   Role：Participation   Title：東京医歯大における国家試験対策の実践

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2017.11   Role：Participation   Title：ARO次世代医療センターの活用方法

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.6   Role：Participation   Title：国立大学改革プランへの対応・東医歯大歯学部改革への取り組み

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role：Participation   Title：CBT問題作成のための説明会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.12   Role：Participation   Title：歯学教育の認証評価

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.3   Role：Participation   Title：Comparisons between US and European Dental Schools – finances, research and clinical experience

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2014.9   Role：Participation   Title：科研費獲得のポイント

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2011.8   Role：Participation   Title：PBLチュートリアル教育　チューター講習会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role：Participation   Title：歯学教育を取り巻く環境変化と求められる対応　＝歯学教育の改善・充 実に関する調査研究協力者会議を中心に＝

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role：Participation   Title：歯科保健医療対策の動向

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Teaching Student Awards

  • 日本味と匂学会第58回大会優秀発表賞

    Classification of award-winning students：Doctoral student   Name of award-winning student：永里　侑貴

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Social Activities

  • 「総合的な探究の時間」における フィールドワーク

    Role(s)：Advisor

    福岡県立春日高等学校  2024.10

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    Audience：High school students

    Type：Research consultation

  • 「総合的な探究の時間」における フィールドワーク

    Role(s)：Advisor

    福岡県立春日高等学校  2023.12

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    Audience：High school students

    Type：Research consultation