担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：(一社)日本小児口腔外科学会  

症例は1歳6ヵ月男児で、上顎歯肉部の腫瘤を主訴に受診した。外耳道炎の既往があり、頭皮の脂漏性湿疹様皮疹、腹部の出血性皮疹、顎下リンパ節腫大を伴い、CTで上顎左側歯槽骨吸収、FDG-PETで高集積を認めた。生検でCD1a陽性のランゲルハンス細胞組織球症と診断し、cytosine Arabinoside(Ara-C)/vincristine(VCR)/prednisolone(PSL)による化学療法を開始した。その結果、腫瘤はほぼ消失し、歯の動揺も消失した。治療終了後約5年で再発や乳歯の形態異常は認めなかった。

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

担当区分：筆頭著者,　責任著者   記述言語：英語   出版者・発行元：Elsevier  

Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4^+ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, where CD4^+ T cells play a significant role. Given these insights, the development of OLP might be influenced by dysbiosis. This study investigates the association between dysbiosis and CD4^+ T cells in OLP. We collected stool and saliva samples from OLP patients, conducting 16S rRNA gene analysis and mass spectrometry, and assessed CD4^+ T cell characteristics in lesions through multiplex immunofluorescence and single-cell RNA sequencing. Peripheral blood samples were subjected to flow cytometry and cell culture assays. Results showed extensive gut dysbiosis in OLP patients, notably a reduction in short-chain fatty acid (SCFA)-producing bacteria essential for regulatory T cell (Treg) differentiation. While various CD4^+ T cell subsets, including Tregs, were present in tissues, these Tregs as unresponsive to specific antigens, showing reduced immunosuppressive molecule expression. The decline in SCFA-producing bacteria correlated with fewer activated Tregs in tissues and blood. These findings suggest that gut dysbiosis may contribute to OLP by impairing Treg regulation, influencing disease pathogenesis.

CiNii Research

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

記述言語：英語   出版者・発行元：Mucosal Immunology  

Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4⁺ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, where CD4⁺ T cells play a significant role. Given these insights, the development of OLP might be influenced by dysbiosis. This study investigates the association between dysbiosis and CD4⁺ T cells in OLP. We collected stool and saliva samples from OLP patients, conducting 16S rRNA gene analysis and mass spectrometry, and assessed CD4⁺ T cell characteristics in lesions through multiplex immunofluorescence and single-cell RNA sequencing. Peripheral blood samples were subjected to flow cytometry and cell culture assays. Results showed extensive gut dysbiosis in OLP patients, notably a reduction in short-chain fatty acid (SCFA)-producing bacteria essential for regulatory T cell (Treg) differentiation. While various CD4⁺ T cell subsets, including Tregs, were present in tissues, these Tregs as unresponsive to specific antigens, showing reduced immunosuppressive molecule expression. The decline in SCFA-producing bacteria correlated with fewer activated Tregs in tissues and blood. These findings suggest that gut dysbiosis may contribute to OLP by impairing Treg regulation, influencing disease pathogenesis.

DOI： 10.1016/j.mucimm.2025.05.009

Web of Science

Scopus

PubMed

開催年月日： 2024年5月

記述言語：日本語  

国名：日本国  

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記述言語：日本語  

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開催年月日： 2023年11月

記述言語：日本語  

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記述言語：日本語  

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開催年月日： 2018年9月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：Amsterdam   国名：オランダ王国