Faculty Profiles - SANO TOMOMI

写真a

SANO TOMOMI

Organization

Faculty of Dental Science Department of Dental Science Assistant Professor
School of Dentistry Department of Dentistry（Concurrent）
Graduate School of Dental Science （Concurrent）
Graduate School of Dental Science Department of Dental Science（Concurrent）

External link

Degree

Ph.D.

Research Interests・Research Keywords

Research theme： basic medical science

Keyword： inflammation, miRNA, singaling

Research period： 2011.4

Awards

第96回日本薬理学会年会優秀ポスター賞

2022.12 日本薬理学会
保存学会奨励賞

2018.6

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歯周炎症が、全身性に増幅される機序を脂肪細胞－マクロファージ相互作用の観点から検討する目的で、共培養系を確立し炎症脂肪組織における高発現遺伝子を網羅的に解析した結果、マクロファージと脂肪細胞の共培養系において、成熟樹状細胞を誘引するCCL19の遺伝子発現が亢進することを見出し、CCL19とその受容体CCR7に着目した。遺伝性・食餌性肥満マウスでは、LPS注入後の血清CCL19濃度が増大し、CCR7欠損マウスでは、食餌誘導性肥満およびインスリン抵抗性の発症が抑制され、アディポネクチン経路および熱産生が亢進した。この現象はエピカテキン (EC) を添加した高脂肪食負荷マウスにおいても観察された。また、脂肪組織において炎症細胞浸潤はみられず、CD11c陽性細胞は野生型マウスでのみ観察された。すなわち、CCL19-CCR7経路が成熟樹状細胞の脂肪組織への遊走・浸潤に関与し、アディポネクチンシグナルおよび熱産生機能の抑制を介して肥満、インスリン抵抗性の発症に関与することを世界に先駆けて示したことに新規性がある。
50th Perio Expo 2017 Poster Award

2017.5 UNC

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Epicatechin (EC) intake appears to be beneficial for the prevention of cardiovascular disorders, and it is well known that adipose tissue inflammation is one of the major risk factors for coronary heart diseases. Additionally, periodontal inflammation has been suggested to accelerate cardiovascular risk via enhancing adipose tissue inflammation. The purpose of the present study was to determine the in vitro and in vivo effects of EC on adipose tissue inflammation and obesity.
DNA microarray analysis was performed to evaluate the effects of EC on gene expression in adipocytes co-cultured with endotoxin-stimulated macrophages. To determine the in vivo effects, C57BL/6 mice were fed either a high-fat diet (HFD) or HFD combined with EC, and metabolic changes were observed.
EC suppressed the expression of many inflammatory genes in the adipocytes co-cultured with endotoxin-stimulated macrophages. Specifically, EC markedly suppressed chemokine (C-C motif) ligand 19 (CCL19) expression. The in vivo study indicated that mice fed the EC-supplemented HFD were protected from diet-induced obesity and insulin resistance. The expression levels of genes associated with inflammation in adipose tissue and in the liver were downregulated in this group of mice.
EC exerts beneficial effects for the prevention of adipose tissue inflammation and insulin resistance. Since the mice deficient in the CCL19 receptor were protected from diet-induced obesity and insulin resistance, the beneficial effects of EC could be mediated, at least in part, by marked suppression of CCL19 expression. Thus, EC may also exert beneficial effects against periodontal inflammation-associated augmentation of cardiovascular risk.

Papers

Epicatechin suppresses the expression of C-C motif chemokine ligand 19 and ameliorates periodontitis. Reviewed

Tomomi Sano, Yusuke Nakatsu, Meiqun Yuan, Rongzhi Li, Tomoichiro Asano, Atsushi Yasunaga, Takashi Kanematsu

Journal of Functional Foods 122 106512 2024.10

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

マウスモデルを使用し、エピカテキンのC-C motif chemokine ligand 19 (CCL19) を介した歯周炎に対する抑制効果を検討し、エピカテキンの持続的な摂取は歯周炎を軽減することを実証した。

DOI： 10.1016/j.jff.2024.106512
Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure. Reviewed International journal

Sano T, Sanada T, Sotomaru Y, Shinjo T, Iwashita M, Yamashita A, Fukuda T, Sanui T, Asano T, Kanematsu T, Nishimura F

Nutr Metab 2019.7

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Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND:
The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resistance. We evaluated the mechanism underlying these protective effects from the standpoint of energy expenditure.
METHODS:
Wild-type and Ccr7 null mice were fed a high-fat diet, and the regulation of energy metabolism and energy metabolism-related molecules, e.g., Ucp1, Cidea, and Pgc1α, were evaluated.
RESULTS:
Food intake did not differ between groups. O2 consumption and CO2 production were higher in Ccr7 null mice than in wild-type mice, despite a similar respiratory quotient and glucose and lipid utilization, suggesting that energy expenditure increased in Ccr7 null mice via enhanced metabolism. In white adipose tissues of Ccr7 null mice, Prdm16, Cd137, Tmem26, Th, and Tbx1 expression increased. Similarly, in brown adipose tissues of Ccr7 null mice, Dio2, Pgc1α, Cidea, Sirt1, and Adiponectin expression increased. In both white and brown adipose tissues, Ucp1 gene and protein expression levels were higher in null mice than in wild-type mice.
CONCLUSIONS:
In Ccr7 null mice, browning of white adipocytes as well as the activation of brown adipocytes cause enhanced energy metabolism, resulting in protection against diet-induced obesity.
Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance. Reviewed International journal

T Sano, S Nagayasu, S Suzuki, M Iwashita, A Yamashita, T Shinjo, T Sanui, A Kushiyama, T Kanematsu, T Asano, F Nishimura

Nutr Metab Cardiovasc Dis. 2017.3

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Language：Japanese Publishing type：Research paper (scientific journal)

Background and aims Epicatechin (EC) intake has been suggested to be beneficial for the prevention of cardiovascular disorders, and it is well known that adipose tissue inflammation is one of the major risk factors for coronary heart diseases. The purpose of the present study was to determine the in vitro and in vivo effects of EC on adipose tissue inflammation and obesity. Methods and results DNA microarray analysis was performed to evaluate the effects of EC on gene expression in adipocytes co-cultured with bacterial endotoxin-stimulated macrophages. To determine the in vivo effects of the catechin, C57BL/6 mice were fed either a high-fat diet (HFD) or HFD combined with EC, and metabolic changes were observed EC suppressed the expression of many inflammatory genes in the adipocytes co-cultured with endotoxin-stimulated macrophages. Specifically, EC markedly suppressed chemokine (C–C motif) ligand 19 (CCL19) expression. The target cell of EC appeared to macrophages. The in vivo study indicated that mice fed the EC-supplemented HFD were protected from diet-induced obesity and insulin resistance. Accordingly, the expression levels of genes associated with inflammation in adipose tissue and in the liver were downregulated in this group of mice. Conclusions EC exerts beneficial effects for the prevention of adipose tissue inflammation and insulin resistance. Since we previously reported that mice deficient in the CCL19 receptor were protected from diet-induced obesity and insulin resistance, it can be concluded that the beneficial effects of EC could be mediated, at least in part, by marked suppression of CCL19 expression.
Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling Reviewed International journal

T sano, M Iwashita, S Nagayasu, A Yamashita, T Shinjo, A Hashikata, T Asano, A Kushiyama, N Ishimaru, Y Takahama, F Nishimura

Obesity 23 ( 7 ) 1460 - 1471 2015.7

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Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1002/oby.21127
Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity Reviewed International coauthorship

Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang

eLife 2025.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.7554/eLife.106362.1
Lipopolysaccharides from Porphyromonas gingivalis indirectly induce neuronal GSK3beta-dependent synaptic defects and cause cognitive decline in a low-amyloid-beta-concentration environment in Alzheimer's disease. Reviewed International coauthorship

Gui S, Zeng F, Wu Z, Nonaka S, Sano T, Ni J, Nakanishi H, Moriyama M, Kanematsu T.

J Alzheimers Dis 13872877251326879 2025.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1177/13872877251326879
Role of Testosterone Signaling in Microglia: A Potential Role for Sex-Related Differences in Alzheimer's Disease. Reviewed International coauthorship

Du H, Mizokami A, Ni J, Zhang S, Yamawaki Y, Sano T, Jimi E, Tanida I, Kanematsu T.

Adv Sci (Weinh) e2413375 2025.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/advs.202413375
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia. Reviewed International coauthorship

Zheng H, Mizokami A, Romera-Giner S, Llera-Oyola J, Yamawaki Y, Sano T, Jimi E, García-García F, Kanematsu T.

Biol Sex Differ. 16 ( 1 ) 9 2025.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13293-025-00686-8
miR-6402 targets Bmpr2 and negatively regulates mouse adipogenesis. Reviewed

Elsheikh M, Sano T, Mizokami A, Nakatsu Y, Asano T, Kanematsu T.

Adipocyte 14 ( 1 ) 2474114 2025.1

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/21623945.2025.2474114
Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity Reviewed International journal

Yusuke Nakatsu, Yasuka Matsunaga, Mikako Nakanishi, Takeshi Yamamotoya, Tomomi Sano, Takashi Kanematsu, Tomoichiro Asano

Biochemical and Biophysical Research Communications 2024.4

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Language：English Publishing type：Research paper (scientific journal)
miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation. Reviewed International journal

Li R, Sano T, Mizokami A, Fukuda T, Shinjo T, Iwashita M, Yamashita A, Sanui T, Nakatsu Y, Sotomaru Y, Asano T, Kanematsu T, Nishimura F

Arch Biochem Biophys 2023.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.abb.2022.109501.
miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress Reviewed International journal

Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F.

Frontiers in Cell and Developmental Biology 2022.12

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XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis Reviewed International journal

Yuki Nishimura, Misaki Iwashita, Masato Hayashi, Takanori Shinjo, Yukari Watanabe, Tatsuro Zeze, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomomi Sano, Tomoichiro Asano & Fusanori Nishimura

Acta Diabetologica 2022.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00592-022-01930-y
RANKL elevation activates the NIK/NF-κB pathway, inducing obesity in ovariectomized mice. Reviewed International journal

Mori K, Mizokami A, Sano T, Mukai S, Hiura F, Ayukawa Y, Koyano K, Kanematsu T, Jimi E.

J Endocrinol. 254 ( 1 ) 27 - 36 2022.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1530/JOE-21-0424
A Case Report of Improved Palmoplantar Pustulosis following Periodontal Treatment and Possible Association with Diminished Systemic Subclinical Inflammation Reviewed International journal

Yamashita A, Sano T, Iwashita M, Nishimura F.

Case Rep Dermatol Med. 2021.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1155/2021/5548760
Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain. Reviewed International journal

Hayashi M, Iwashita M, Nishimura Y, Shinjo T, Sano T, Yamashita A, Fukuda T, Sanui T, Asano T, Nishimura F.

BMJ Open Diabetes Res Care. 9 ( 1 ) 2021.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1136/bmjdrc-2020-001871.
Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and suppresses tumor growth in a xenograft mouse model Reviewed International journal

Maetani Y, Asano S, Mizokami A, Yamawaki Y, Sano T, Hirata M, Irifune M, Kanematsu T.

Biochem Biophys Res Commun. 2021.5

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Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis. Reviewed International journal

Mukai S, Mizokami A, Otani T, Sano T, Matsuda M, Chishaki S, Gao J, Kawakubo-Yasukochi T, Tang R, Kanematsu T, Takeuchi H, Jimi E, Hirata M.

J Biol Chem. 2021.1

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SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism Reviewed International journal

Rehab Alshargabi, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Tomomi Sano, Yuki Nishimura, Masato Hayashi, Tatsuro Zeze, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

Biochem Biophys Res Commun 2020.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2020.09.129
SPOCK1 Is a Novel Inducer of Epithelial to Mesenchymal Transition in Drug-Induced Gingival Overgrowth. Reviewed International journal

Alshargabi R, Sano T, Yamashita A, Takano A, Sanada T, Iwashita M, Shinjo T, Fukuda T, Sanui T, Kishida S, Nishimura F.

Sci Rep. 10 ( 1 ) 9785 2020.7

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Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues Reviewed

Taiki Sanada, Tomomi Sano, Yusuke Sotomaru, Rehab Alshargabi, Yosuke Yamawaki, Akiko Yamashita, Hiroaki Matsunaga, Misaki Iwashita, Takanori Shinjo, Takashi Kanematsu, Tomoichiro Asano, Fusanori Nishimura

Biochemistry and Biophysics Reports 22 2020.7

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MicroRNA (miRNA) plays an important role in diverse cellular biological processes such as inflammatory response, differentiation and proliferation, and carcinogenesis. miR-146a has been suggested as a negative regulator of the inflammatory reaction. Although, it has been reported as expressed in inflamed adipose and periodontal tissues, however, miR-146a's inhibitory effects against inflammatory response in both the tissues, are not well understood. Therefore, in this study, the inhibitory effects of miR-146a on both adipose and periodontal inflammation, was investigated. In vitro study has revealed that miR-146a transfection into either adipocytes or gingival fibroblasts, has resulted in a reduced cytokine gene expression, observed on co-culturing the cells with macrophages in the presence of lipopolysaccharides (LPS), in comparison to the control miRNA transfected. Similarly, miR-146a transfection into macrophages resulted in a reduced expression of TNF-α gene and protein in response to LPS stimulation. In vivo study revealed that a continuous intravenous miR-146a administration into mice via tail vein, protected the mice from developing high-fat diet-induced obesity and the inflammatory cytokine gene expression was down-regulated in both adipose and periodontal tissues. miR-146a appeared to be induced by macrophage-derived inflammatory signals such as TNF-α by negative feed-back mechanism, and it suppressed inflammatory reaction in both adipose and periodontal tissues. Therefore, miR-146a could be suggested as a potential therapeutic molecule and as a common inflammatory regulator for both obesity-induced diabetes and related periodontal diseases.

DOI： 10.1016/j.bbrep.2020.100757
Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice. Invited Reviewed International journal

Inoue MK, Matsunaga Y, Nakatsu Y, Yamamotoya T, Ueda K, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Iwashita M, Sano T, Nishimura F, Morii K, Sasaki K, Masaki T, Asano T

Diabetol Metab Synd 2019.7

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Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles. Reviewed International journal

Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata-Tsuchiya S, Nakao Y, Sano T, Yamashita A, Yamada S, Ohta K, Shiba H, Nishimura F.

Sci Rep. 2019.3

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Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16. Reviewed International journal

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.

Cell Rep. 2019.3

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IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes. Reviewed International journal

新城尊徳, 岩下未咲, 山下明子, 佐野朋美, 鶴田　満大, 松永　紘明, 讃井彰一, 浅野知一郎, 西村英紀

Biochemical and Biophysical Research Communications 477 ( 2 ) 241 - 246 2016.8

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DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappa B activation Invited Reviewed International journal

新城尊徳, 中津祐介, 岩下未咲, 佐野朋美, 迫田秀之, 石原寿光, 櫛山暁史, 藤城緑, 福嶋俊明, 土谷佳弘, 鎌田英明, 西村英紀, 浅野知一郎

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 309 ( 3 ) E214 - E223 2015.8

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Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1152/ajpendo.00553.2014
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice Invited Reviewed International journal

新城尊徳, 中津祐介, 岩下未咲, 佐野朋美, 迫田秀之, 石原寿光, 櫛山暁史, 藤城緑, 西村英紀, 浅野知一郎

DIABETOLOGY & METABOLIC SYNDROME 7 2015.6

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Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13098-015-0047-y

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Books

QUINT DIARY 2023

佐野朋美他（Role：Joint author）

クインテッセンス出版株式会社 2023.1

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Language：Japanese Book type：Scholarly book
糖尿病合併症　管理・フォローアップ　Ⅲ章「慢性合併症の管理」．

佐野朋美、西村英紀（Role：Joint author）

文光堂 2021.2

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Language：Japanese
月刊糖尿病　6「歯周病と糖尿病」． Vol.11 No.4

佐野朋美、西村英紀

2019.10

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Language：Japanese
患者さんのエイジングに備える・高齢者への歯周治療と口腔管理

佐野朋美他

インターアクション株式会社 2018.3

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Language：Japanese

Presentations

Epicatechin suppresses C-C motif chemokine ligand 19 expression and ameliorates periodontitis International conference

Tomomi Sano, Meiqun Yuan, Akiko Mizokami, Takashi Kanematsu

ASCEPT, APFP & APSA Joint Congress 2024.12 Asia Pacific Federation of Pharmacologists

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Event date： 2024.12

Language：English Presentation type：Poster presentation

Venue：Malborne Country：Australia
Epicatechin suppresses C-C motif chemokine ligand 19 expression in gingival fibroblast and ameliorates periodontitis

Tomomi Sano, Yuan Meiqun, Akiko Mizokami, Takashi Kanematsu

第66回歯科基礎医学会学術大会 2024.11 歯科基礎医学会

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Event date： 2024.11

Language：English

Venue：長崎
Deficiency of PLCL in tumor-associated macrophages induces cancer malignancy by exacerbating the tumor microenvironment

佐野朋美、Malaz Elsheikh、溝上顕子、兼松隆

第97回日本薬理学会年会 2023.12

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Event date： 2023.12

Language：English

Venue：神戸 Country：Japan
Epicatechin exerts anti-inflammatory effect on periodontitis through suppression of CCL19 expression

Tomomi Sano, Rongzhi Li, Fusanori Nishimura, Takashi Kanematsu

第96回日本生化学会大会 2023.10

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Event date： 2023.10 - 2023.11

Language：English

Venue：福岡 Country：Japan
RAW264.7においてmiR-15b-5pはCcr7を標的とし、M1マクロファージへの分化を抑制する

佐野朋美、溝上顕子、兼松隆

第76回日本薬理学会西南部会 2023.10

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Event date： 2023.10

Language：Japanese

Venue：沖縄 Country：Japan
Study on the effect of PRIP on the polarization of M1/M2 macrophages

Tomomi Sano, Malaz Elsheikh, Akiko Mizokami, Tamotsu Kiyoshima, Takashi Kanematsu

第65回歯科基礎医学会学術大会 2023.9

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Event date： 2023.9

Language：English

Venue：東京 Country：Japan
miR-582-5p, that targets Skp1 and suppresses NF-κB signaling-mediated inflammation, is down-regulated in periodontitis and obesity

Li Rongzhi, Tomomi Sano, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Fusanori Nishimura

日本歯科保存学会2023年度春季大会（第158回） 2023.6

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Event date： 2023.6

Language：English

Venue：松江 Country：Japan
Regulatory mechanisms of tumor-associated macrophages in the tumor microenvironment

Tomomi Sano, Du Haiyan, Akiko Mizokami, Takashi Kanematsu

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2023.6

Language：English

Venue：徳島 Country：Japan
Identification and characterization of a microRNA regulating adipocyte inflammation

Malaz Elsheikh, Tomomi Sano, Akiko Mizokami, Takashi Kanematsu

第64回歯科基礎医学会学術大会 2022.9

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Event date： 2023.6

Language：English

Venue：徳島 Country：Japan
MicroRNA targeting Skp1 regulates inflammatory response through NF-κB signaling pathway

Tomomi Sano, Rongzhi Li, Akiko Mizokami, Fusanori Nishimura, Takashi Kanematsu

第96回日本薬理学会年会 2022.12

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Event date： 2023.6

Language：English

Venue：横浜 Country：Japan
脂肪組織炎症でCCL19-CCR7経路が制御するmicroRNAの同定

佐野朋美、Malaz Elsheikh、溝上顕子、兼松隆

第63回歯科基礎医学会学術大会 2021.10

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Event date： 2021.10

Language：Japanese

Venue：Web Country：Japan
Identification of microRNAs involved in adipose tissue inflammation.

Tomomi Sano

2019 Taiwan Academy of Periodontology Annual Meeting and International Symposium 2019.11

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Event date： 2019.11

Language：English

Venue：Howard Civil Service International House, Taipei Country：Taiwan, Province of China
Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues. International conference

Tomomi Sano

The 59th General Session of Korean Academy of Periodontology 2019.11

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Event date： 2019.11

Language：English

Venue：Gwanggaeto Building, Sejong University, Seoul Country：Korea, Republic of
脂肪・歯周組織で発現誘導されるmiRNA-146aによる抗炎症効果の検討

真田大樹、佐野朋美

第151回日本歯科保存学会2019年度秋季学術大会 2019.10

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Event date： 2019.10

Language：Japanese

Venue：福岡国際会議場（福岡市） Country：Japan
IDENTIFICATION OF MICRORNAS INVOLVED IN ADIPOSE TISSUE INFLAMMATION. International conference

Sano Tomomi

13th Asian Pacific Society of Periodontology Meeting 2019.9

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Event date： 2019.9

Language：English

Venue：Royale Chulan, Kuala Lumpur Country：Malaysia
Increased energy expenditure and resistance to obesity in CCR7KO mice. International conference

Sano Tomomi

The 96th General Session of the IADR 2018.7

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Event date： 2019.6

Language：English

Country：Japan
The Role of Proteoglycans In Drug Induced Gingival Overgrowth (DIGO)

Rehab Alshargabi, Tomomi Sano

第149回日本歯科保存学会2018年度秋季学術大会 2018.11

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Event date： 2019.6

Language：English

Country：Japan
脂肪・歯周組織における抗炎症効果の検討

眞田大樹、佐野朋美

平成30年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会 2018.11

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Event date： 2019.6

Language：Japanese

Country：Japan
脂肪・歯周組織で発現誘導されるmiRNAによる抗炎症効果の検討

眞田大樹、佐野朋美

第62回春季日本歯周病学会学術大会 2019.5

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Event date： 2019.5

Language：Japanese

Venue：神奈川県民ホール（横浜市） Country：Japan
CCR7欠損マウスにおける脂肪および歯周組織炎症抑制機序の考察

佐野朋美

第61回秋季日本歯周病学会学術大会 2018.10

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Event date： 2018.10

Language：Japanese

Country：Japan
Influences of energy metabolism via CCL19-CCR7 pathway on diet-induced obesity and insulin resistance. International conference

佐野　朋美

The 12th meeting of the Asian Pacific Society of Periodontology. 2017.9

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Event date： 2018.6

Language：English

Country：Korea, Republic of
Study on the mechanism of increased energy expenditure of CCR7 deficient mouse. International conference

佐野　朋美

The 65th Annual Meeting of Japanese Association for Dental Research. 2017.11

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Event date： 2018.6

Language：English

Country：Japan
エピカテキンは歯肉線維芽細胞─マクロファージ相互作用による過剰な炎症反応を抑制する

眞田大樹、佐野朋美

日本歯周病学会60周年記念京都大会 2017.12

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Event date： 2018.6

Language：Japanese

Country：Japan
炎症脂肪/歯周組織における抗炎症分子の探索研究

眞田大樹、佐野朋美

日本歯科保存学会2018年度春季学術大会 2018.6

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Event date： 2018.6

Language：Japanese

Country：Japan
CCR7欠損マウスにおけるエネルギー消費亢進機序についての検討

佐野　朋美

日本歯科保存学会2017年度秋季学術大会 2017.10

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Event date： 2017.10 - 2018.6

Language：Japanese

Country：Japan
CCL19-CCR7経路を介したエネルギー代謝機構が肥満およびインスリン抵抗性に及ぼす影響の機序に関する検討

佐野朋美

日本歯科保存学会2017年度春季学術大会 2017.6

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Event date： 2017.6

Language：Japanese

Venue：青森 Country：Japan
エネルギー代謝機構がCCL19-CCR7経路を介した肥満およびインスリン抵抗性に及ぼす影響に関する検討

佐野朋美

第60回日本糖尿病学会年次学術集会 2017.5

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Event date： 2017.5

Language：Japanese

Venue：名古屋 Country：Japan
Epicatechin Down-regulates Adipose Tissue CCL19 Expression, Thereby Ameliorates Diet-induced Obesity and Insulin Resistance International conference

佐野朋美

UNC Perio 2017 EXPO 2017.5

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Event date： 2017.5

Language：English

Venue：Chapel Hill, North Carolina Country：United States
Epicatechin Down-regulates Inflammatory Genes in Adipocytes Co-cultured with Endotoxin-activated Macrophages International conference

山下明子, 佐野朋美

The 95th General Session & Exhibition of the IADR 2017.3

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Event date： 2017.3

Language：English

Venue：San Francisco, Calif. Country：United States
Epicatechin Down-regulates Adipose Tissue CCL19 Expression, Thereby Ameliorates Diet-induced Obesity International conference

佐野朋美

The 95th General Session & Exhibition of the IADR 2017.3

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Event date： 2017.3

Language：English

Venue：San Francisco, Calif. Country：United States
IL-17Aは3T3-L1脂肪細胞におけるTNF-α誘導性IL-6・CCL20産生を相乗的に増強する

佐野朋美

第145回日本歯科保存学会秋季学術大会 2016.10

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Event date： 2017.2

Language：Japanese

Venue：松本 Country：Japan
エピカテキンは脂肪細胞‐マクロファージ相互作用による過剰な炎症反応を抑制する

佐野朋美

第59回秋季日本歯周病学会学術大会 2016.10

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Event date： 2017.2

Language：Japanese

Venue：新潟 Country：Japan
TLR-4リガンド刺激マクロファージと共存する脂肪細胞で発現するケモカインの網羅的解析

佐野朋美

第55回春季日本歯周病学会学術大会 2012.5

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Event date： 2016.5

Language：Japanese

Venue：札幌コンベンションセンター（北海道） Country：Japan
CCL19-CCR7経路がエネルギー消費に及ぼす影響に関する検討

佐野朋美

第58回春季日本歯周病学会学術大会 2015.5

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Event date： 2015.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：幕張メッセ（千葉） Country：Japan
CCR7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討

佐野朋美

第57回春季日本歯周病学会学術大会 2014.5

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Event date： 2014.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：長良川国際会議場（岐阜） Country：Japan
CCR7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討

岩下未咲, 佐野朋美

第57回日本糖尿病学会年次学術集会 2014.5

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Event date： 2014.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪国際会議場（大阪） Country：Japan

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MISC

Epicatechin: Potential Use as Anti-Obese and Anti-Periodontal Nutrient Invited Reviewed

Tomomi Sano, Malaz Elsheikh, Takashi Kanematsu

Current Oral Health Reports 2024.9

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

DOI： 10.1007/s40496-024-00390-3
The Influence of Periodontal Burden on Metabolic Control of Diabetes - Myth or Reality? - from a Nutritional Perspective.

西村英紀, 佐野朋美, 讃井彰一

Current Oral Health Reports 2017.6

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Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Professional Memberships

Japanese Association for Oral Biology
The International Association for Dental Research
日本薬理学会
日本生化学会

Academic Activities

Associate Editor International contribution

Role(s)： Review, evaluation,　Peer review

2024 - Present

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Type：Peer review
学術論文等の審査 International contribution

Role(s)： Peer review

2024

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3
Screening of academic papers

Role(s)： Peer review

2023

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：2
Screening of academic papers

Role(s)： Peer review

2022

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3
Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：2
Screening of academic papers

Role(s)： Peer review

2020

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：4

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Research Projects

UAAT International Young Visiting Scholar Program International coauthorship

2025.2

University Academic Alliance in Taiwan UAAT International Young Visiting Scholar Program UAAT International Young Visiting Scholar Program

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Authorship：Principal investigator Grant type：Joint research
組織慢性炎症を制御するM2マクロファージの機能解析研究

Grant number：24K12872 2024 - 2026

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
miRNAを標的とした薬剤性歯肉増殖症新規治療薬の開発

Grant number：24K12947 2024 - 2026

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
マクロファージ機能を制御するmiRNAを応用した新規歯周病治療薬の開発

Grant number：23K09119 2023 - 2025

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Principal investigator Grant type：Scientific research funding
歯肉増殖症や肥満に関わる新規分子SPOCK1のシグナリング経路の探索

Grant number：21K09897 2021 - 2023

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
抗腫瘍免疫を賦活化する新しい制癌シグナル分子の機能解明研究

Grant number：21K09817 2021 - 2023

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
肥満および歯周炎に共通のmiRNAを標的とした新規抗炎症治療薬の開発

Grant number：20K18512 2020 - 2022

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists

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Authorship：Principal investigator Grant type：Scientific research funding
SPOCK-1生体タンパクを応用した安全性に優れた革新的歯周病予防薬の開発

Grant number：19K22721 2019 - 2021

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Challenging Research(Exploratory)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
抗炎症miRNA内包エクソソームを用いた肥満糖尿病性歯周炎の新規治療法の開発

Grant number：18K17071 2018 - 2020

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists

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Authorship：Principal investigator Grant type：Scientific research funding
エピカテキンの抗炎症効果の検証～脂肪組織炎症および実験的歯周炎モデルにおける検討

Grant number：16H07067 2016 - 2017

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up

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Authorship：Principal investigator Grant type：Scientific research funding
CCL19-CCR7経路を標的とした脂肪組織炎症および歯周炎抑制効果の検討

2016

平成２８年度研究活動基礎支援制度ダイバーシティ研究環境実現イニシアティブ

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.

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Educational Activities

大学院教育
学部教育

Class subject

Aging Science and Pharmacology(Core) D

2025.12 - 2026.2 Winter quarter
薬理学３

2025.12 - 2026.2 Winter quarter
Aging Science and Pharmacology(Upper-grade) D

2025.12 - 2026.2 Winter quarter
Aging Science and Pharmacology(Core) C

2025.10 - 2025.12 Fall quarter
臨床歯科薬理学

2025.10 - 2025.12 Fall quarter
Aging Science and Pharmacology(Upper-grade) C

2025.10 - 2025.12 Fall quarter
リサーチエクスポージャー

2025.6 - 2026.6 Full year
薬理学2

2025.6 - 2025.8 Summer quarter
Aging Science and Pharmacology(Core) B

2025.6 - 2025.8 Summer quarter
Aging Science and Pharmacology(Upper-grade) B

2025.6 - 2025.8 Summer quarter
薬理学１

2025.4 - 2025.6 Spring quarter
Aging Science and Pharmacology(Upper-grade) A

2025.4 - 2025.6 Spring quarter
Aging Science and Pharmacology(Core) A

2025.4 - 2025.6 Spring quarter
アーリーエクスポージャー

2025.4 - 2025.6 Spring quarter
薬理学3

2024.12 - 2025.2 Winter quarter
Aging Science and Pharmacology(Core) D

2024.12 - 2025.2 Winter quarter
Aging Science and Pharmacology(Upper-grade) D

2024.12 - 2025.2 Winter quarter
臨床歯科薬理学

2024.10 - 2024.12 Fall quarter
Aging Science and Pharmacology(Core) C

2024.10 - 2024.12 Fall quarter
Aging Science and Pharmacology(Upper-grade) C

2024.10 - 2024.12 Fall quarter
Aging Science and Pharmacology(Upper-grade) B

2024.6 - 2024.8 Summer quarter
Aging Science and Pharmacology(Core) B

2024.6 - 2024.8 Summer quarter
薬理学2

2024.6 - 2024.8 Summer quarter
Aging Science and Pharmacology(Core) A

2024.4 - 2024.6 Spring quarter
Aging Science and Pharmacology(Upper-grade) A

2024.4 - 2024.6 Spring quarter
薬理学1

2024.4 - 2024.6 Spring quarter
リサーチエクスポージャー

2024.4 - 2024.6 Spring quarter
Aging Science and Pharmacology (Upper-grade) D

2023.12 - 2024.2 Winter quarter
薬理学3

2023.12 - 2024.2 Winter quarter
Aging Science and Pharmacology(Core) D

2023.12 - 2024.2 Winter quarter
Aging Science and Pharmacology (Upper-grade) C

2023.10 - 2023.12 Fall quarter
臨床歯科薬理学

2023.10 - 2023.12 Fall quarter
Aging Science and Pharmacology(Core) C

2023.10 - 2023.12 Fall quarter
Aging Science and Pharmacology (Upper-grade) B

2023.6 - 2023.8 Summer quarter
薬理学2

2023.6 - 2023.8 Summer quarter
Aging Science and Pharmacology(Core) B

2023.6 - 2023.8 Summer quarter
歯科薬理学

2023.4 - 2024.3 Full year
リサーチエクスポージャー

2023.4 - 2024.3 Full year
薬理学1

2023.4 - 2023.6 Spring quarter
Aging Science and Pharmacology(Core) A

2023.4 - 2023.6 Spring quarter
Aging Science and Pharmacology (Upper-grade) A

2023.4 - 2023.6 Spring quarter
歯科薬理学

2022.4 - 2023.3 Full year
口腔機能分子科学（低年次）

2022.4 - 2023.3 Full year
口腔機能分子科学（コア）

2022.4 - 2023.3 Full year
リサーチエクスポージャー

2022.4 - 2022.9 First semester
Advanced Dental Science Research（口腔機能分子科学）

2021.4 - 2022.3 Full year
歯科薬理学

2021.4 - 2021.9 First semester
Advanced Dental Science Research（口腔機能分子科学）

2020.12 - 2021.2 Winter quarter
歯科薬理学

2020.10 - 2021.3 Second semester
歯周病学Ⅱ

2020.4 - 2020.9 First semester
総合歯科学

2019.10 - 2020.3 Second semester
歯周病学Ⅰ

2019.10 - 2020.3 Second semester
歯周病学Ⅱ

2019.4 - 2019.9 First semester
総合歯科学

2018.10 - 2019.3 Second semester
歯周病学Ⅱ

2018.4 - 2018.9 First semester
歯周病学Ⅰ

2017.10 - 2018.3 Second semester
総合歯科学

2017.10 - 2018.3 Second semester
総合歯科学

2016.10 - 2017.3 Second semester

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FD Participation

2020.6 Role：Participation Title：ジャーナルをめぐる現状と論文の投稿・入手について

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.6 Role：Participation Title：科研費申請のススメ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.10 Role：Panelist Title：馬出地区3部局合同男女共同参画FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.8 Role：Participation Title：IR室による歯学研究院の研究力分析

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.3 Role：Participation Title：東京医歯大における国家試験対策の実践

Organizer：[Undergraduate school/graduate school/graduate faculty]

Teaching Student Awards

歯科基礎医学会モリタ優秀発表賞

Year and month of award：2024.11

Classification of award-winning students：Doctoral student Name of award-winning student：Malaz Elsheikh

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優秀発表

Outline of Social Contribution and International Cooperation activities

UAAT International Young Visiting Scholar Program

Travel Abroad

2025.2 - 2025.3

Staying countory name 1：Taiwan, Province of China Staying institution name 1：Taipei Medical University

Year of medical license acquisition

2011

Information

Information

Degree

Degree

Research Interests・Research Keywords

Research Interests・Research Keywords

Awards

Awards

Papers

Papers

Books

Books

Presentations

Presentations

MISC

MISC

Professional Memberships

Professional Memberships

Academic Activities

Academic Activities

Research Projects

Research Projects

Educational Activities

Educational Activities

Class subject

Class subject

FD Participation

FD Participation

Teaching Student Awards

Teaching Student Awards

Outline of Social Contribution and International Cooperation activities

Outline of Social Contribution and International Cooperation activities

Travel Abroad

Travel Abroad

Year of medical license acquisition

Year of medical license acquisition