Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder Reviewed

Huong Thi Nguyen Nguyen, Hiroki Kato, Hiroshi Sato, Haruyoshi Yamaza, Yasunari Sakai, Shoichi Ohga, Kazuaki Nonaka, Keiji Masuda

Biochemical and Biophysical Research Communications   2019.1

Folic acid-mediated mitochondrial activation for protection against oxidative stress in human dental pulp stem cells derived from deciduous teeth Reviewed

Yu Zhang, Hiroki Kato, Hiroshi Sato, Haruyoshi Yamaza, Yuta Hirofuji, Xu Han, Keiji Masuda, Kazuaki Nonaka

Biochemical and biophysical research communications   2019.1

Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder Reviewed

Huong Thi Nguyen Nguyen, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Thanh Thi Mai Pham, Fumiko Takayama, Yasunari Sakai, Shoichi Ohga, Tomoaki Taguchi, Kazuaki Nonaka

Biochemistry and Biophysics Reports   16   24 - 31   2018.12

Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome Reviewed

Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Zhang, Tomoaki Taguchi, Kazuaki Nonaka

BMC Neurology   18 ( 1 )   2018.8

Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome Reviewed

Saki Hirofuji, Yuta Hirofuji, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Hiroshi Sato, Fumiko Takayama, Michiko Torio, Yasunari Sakai, Shoichi Ohga, Tomoaki Taguchi, Kazuaki Nonaka

Biochemical and Biophysical Research Communications   498 ( 4 )   898 - 904   2018.4

Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1 Reviewed

Yumiko I. Matsuishi, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Hiroko Wada, Tamotsu Kiyoshima, Kazuaki Nonaka

Biochemical and Biophysical Research Communications   495 ( 2 )   1655 - 1660   2018.1

Direct effects of mitochondrial dysfunction on poor bone health in Leigh syndrome Reviewed

Hiroki Kato, Xu Han, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Thanh Thi Mai Pham, Tomoaki Taguchi, Kazuaki Nonaka

Biochemical and Biophysical Research Communications   493 ( 1 )   207 - 212   2017.11

Mitochondria regulate the differentiation of stem cells from human exfoliated deciduous teeth Reviewed

Hiroki Kato, Thanh Thi Mai Pham, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Xu Han, Hiroshi Sato, Tomoaki Taguchi, Kazuaki Nonaka

Cell Structure and Function   42 ( 2 )   105 - 116   2017.5

Tom70 Is Essential for PINK1 Import into Mitochondria Reviewed

Hiroki Kato, Qiping Lu, Doron Rapaport, Vera Kozjak-Pavlovic

PLoS One   8 ( 3 )   2013.3

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane Reviewed

Hiroki Kato, Katsuyoshi Mihara

Biochemical and Biophysical Research Communications   369 ( 3 )   958 - 963   2008.5

Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase Reviewed

Hiroki Kato, Kenjiro Sakaki, Katsuyoshi Mihara

Journal of Cell Science   119 ( 11 )   2342 - 2353   2006.6

Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons Reviewed

Ryoji Taira;Satoshi Akamine;Sayaka Okuzono;Fumihiko Fujii;Eriko Hatai;Kousuke Yonemoto;Ryuichi Takemoto;Hiroki Kato;Keiji Masuda;Takahiro A. Kato;Ryutaro Kira;Keita Tsujimura;Kenichiro Yamamura;Norio Ozaki;Shouichi Ohga;Yasunari Sakai

Scientific Reports   14 ( 1 )   2024.7

An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice Reviewed

Sayaka Okuzono;Fumihiko Fujii;Daiki Setoyama;Ryoji Taira;Yohei Shinmyo;Hiroki Kato;Keiji Masuda;Kousuke Yonemoto;Satoshi Akamine;Yuki Matsushita;Yoshitomo Motomura;Takeshi Sakurai;Hiroshi Kawasaki;Kihoon Han;Takahiro A. Kato;Hiroyuki Torisu;Dongchon Kang;Yusaku Nakabeppu;Shouichi Ohga;Yasunari Sakai

Genes to Cells   2024.7

ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress. Reviewed

Fumihiko Fujii;Hikaru Kanemasa;Sayaka Okuzono;Daiki Setoyama;Ryoji Taira;Kousuke Yonemoto;Yoshitomo Motomura;Hiroki Kato;Keiji Masuda;Takahiro A Kato;Shouichi Ohga;Yasunari Sakai

Disease models & mechanisms   2024.5

Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. Reviewed International journal

Zakaria, F., Sonoda, S., Kato, H., Ma, L., Uehara, N., Kyumoto-Nakamura, Y., Sharifa, M., Yu, L., Dai, L., Yamauchi-Tomoda, E., Aijima, R., Yamaza, H., Nishimura, F., Yamaza, T.

Sci Rep.   2024.3

Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Invited Reviewed International journal

Uehara, N., Shibusawa, N., Mikami, Y., Kyumoto-Nakamura, Y., Sonoda, S., Kato, H., Yamaza, T., Kukita, T.

Arch Biochem Biophys.   2023.11

TRPV4-mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons. Reviewed International journal

2023.10

Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca2+ regulation in autism spectrum disorder. Reviewed International journal

Dong, S., Kifune, T., Kato, H., Wang, L., Kong, J., Hirofuji, Y., Sun, X., Sato, H., Ito, Y., Kato, T.A., Sakai, Y., Ohga, S., Fukumoto, S., Masuda, K.

Biochem Biophys Res Commun.   2023.9

Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency Reviewed International journal

Sun, Xiao; Dong, Shuangshan; Kato, Hiroki; Kong, Jun; Ito, Yosuke; Hirofuji, Yuta; Sato, Hiroshi; Kato, Takahiro A.; Sakai, Yasunari; Ohga, Shouichi; Fukumoto, Satoshi; Masuda, Keiji

ANTIOXIDANTS   11 ( 7 )   2022.7

Stem cells from human exfoliated deciduous teeth attenuate mechanical allodynia in mice through distinct from the siglec-9/MCP-1-mediated tissue-repairing mechanism Invited Reviewed International journal

Hayashi, Yoshinori; Kato, Hiroki; Nonaka, Kazuaki; Nakanishi, Hiroshi

SCIENTIFIC REPORTS   11 ( 1 )   2021.10

Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia Reviewed International journal

Xiao Sun, Hiroki Kato, Hiroshi Sato, Michiko Torio, Xu Han, Yu Zhang, Yuta Hirofuji, Takahiro A Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda

Biochemistry and Biophysics Reports   ( 26 )   100968   2021.7

Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus Reviewed International journal

Sonoda, Soichiro; Murata, Sara; Kato, Hiroki; Zakaria, Fouad; Kyumoto-Nakamura, Yukari; Uehara, Norihisa; Yamaza, Haruyoshi; Kukita, Toshio; Yamaza, Takayoshi

JOURNAL OF IMMUNOLOGY   206 ( 12 )   3053 - 3063   2021.6

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders Invited Reviewed International journal

Masuda, Keiji; Han, Xu; Kato, Hiroki; Sato, Hiroshi; Zhang, Yu; Sun, Xiao; Hirofuji, Yuta; Yamaza, Haruyoshi; Yamada, Aya; Fukumoto, Satoshi

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 5 )   2021.3

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons Reviewed International journal

Akamine, Satoshi; Okuzono, Sayaka; Yamamoto, Hiroyuki; Setoyama, Daiki; Sagata, Noriaki; Ohgidani, Masahiro; Kato, Takahiro A.; Ishitani, Tohru; Kato, Hiroki; Masuda, Keiji; Matsushita, Yuki; Ono, Hiroaki; Ishizaki, Yoshito; Sanefuji, Masafumi; Saitsu, Hirotomo; Matsumoto, Naomichi; Kang, Dongchon; Kanba, Shigenobu; Nakabeppu, Yusaku; Sakai, Yasunari; Ohga, Shouichi

FASEB JOURNAL   34 ( 12 )   16601 - 16621   2020.12

Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients Reviewed International journal

Neuropsychopharmacol Rep.   2020.10

Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model Reviewed

Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza

Stem Cell Research and Therapy   11 ( 1 )   2020.7

Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells Reviewed

Hiroshi Sato, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Huong Thi Nguyen Nguyen, Thanh Thi Mai Pham, Xu Han, Yuta Hirofuji, Kazuaki Nonaka

BioMed Research International   2017   2017.1

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60 Reviewed

Shiori Akabane, Midori Uno, Naoki Tani, Shunta Shimazaki, Natsumi Ebara, Hiroki Kato, Hidetaka Kosako, Toshihiko Oka

Molecular Cell   62 ( 3 )   371 - 384   2016.5

Mitochondrial physiology and cerebrospinal protection

Morika Suzuki, Hiroki Kato, Naomi Hachiya

Neuroanesthesia and Cerebrospinal Protection   63 - 70   2015.8

Propofol prevents mitochondrial fragmentation Reviewed

Morika Suzuki, Hiroyuki Uchino, Hiroki Kato

Journal of Tokyo Medical University   73 ( 3 )   268 - 275   2015.1

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1 Reviewed

Cell Death and Disease   5 ( 4 )   2014.1

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation Reviewed

Tohru Ichimura, Masato Taoka, Ikuo Shoji, Hiroki Kato, Tomonobu Sato, Shigetsugu Hatakeyama, Toshiaki Isobe, Naomi Hachiya

Journal of Cell Science   126 ( 9 )   2014 - 2026   2013.5

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease Functional impact of disease-related variants on mitochondrial homeostasis Reviewed

Human Molecular Genetics   19 ( 22 )   4437 - 4452   2010.11

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging Reviewed

Journal of Experimental Medicine   207 ( 2 )   379 - 390   2010.2

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice Reviewed

Naotada Ishihara, Masatoshi Nomura, Akihiro Jofuku, Hiroki Kato, Satoshi Suzuki, Keiji Masuda, Hidenori Otera, Yae Nakanishi, Ikuya Nonaka, Yu Ichi Goto, Naoko Taguchi, Hidetaka Morinaga, Maki Maeda, Ryoichi Takayanagi, Sadaki Yokota, Katsuyoshi Mihara

Nature Cell Biology   11 ( 8 )   958 - 966   2009.7

Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c Reviewed

Toshihiko Oka, Tomoko Sayano, Shoko Tamai, Sadaki Yokota, Hiroki Kato, Gen Fujii, Katsuyoshi Mihara

Molecular Biology of the Cell   19 ( 6 )   2597 - 2608   2008.6

A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments Reviewed

Hidenori Otera, Yohsuke Taira, Chika Horie, Yurina Suzuki, Hiroyuki Suzuki, Kiyoko Setoguchi, Hiroki Kato, Toshihiko Oka, Katsuyoshi Mihara

Journal of Cell Biology   179 ( 7 )   1355 - 1363   2007.12

Folic acid-mediated mitochondrial activation for protection against oxidative stress in human dental pulp stem cells derived from deciduous teeth

2019.5 

ヒト歯髄幹細胞を用いた変容性骨異形成症の病態再現と機能解明

韓旭、 加藤大樹、 山座治義、 廣藤雄太、 増田啓次、 福本敏

第58回日本小児歯科学会大会  2020.4 

GαOは細胞内カルシウム依存性シグナルを制御する

平良遼志、赤峰哲、奥園清香、山元裕之、米元耕輔、石崎義人、實藤雅文、佐方功明、扇谷昌宏、加藤隆弘、加藤大樹、増田啓次、神庭重信、酒井康成、大賀正一

第63回日本小児神経学会学術集会  2021.5 

ダウン症候群の乳歯歯髄幹細胞から分化したドーパミン作動性ニューロンにおける神経突起発達とドーパミン調節障害

孫梟、加藤大樹、韓旭、張虞、佐藤浩、加藤隆弘、酒井康成、大賀正一、福本敏、増田啓次

第63回日本小児神経学会学術集会  2021.5 

MFF機能不全のヒト乳歯由来幹細胞から分化したドーパミン作動性ニューロンにおけるミトコンドリアのカルシウム過負荷と酸化ストレス

BPCNPNPPP4学会合同年会  2022.11 

脱落乳歯を活用したミトコンドリア病研究

加藤大樹、韓旭、佐藤浩、山座治義、増田啓次、廣藤雄太、野中和明

第18回日本ミトコンドリア学会年会  2018.12 

Pathological analysis of autism spectrum disorder using deciduous tooth-derived stem cells.

2019.5 

注意欠如多動症の男児由来の乳歯歯髄幹細胞から分化したドーパミン作動性ニューロンの神経突起成長とミトコンドリア機能の障害はBDNFにより改善する

Nguyen, H.T.N.、加藤大樹、佐藤浩、野中和明、増田啓次

第41回日本生物学的精神医学会  2019.6 

HeLa細胞における21番染色体トリソミーのダイソミー化

佐藤　浩、加藤　大樹、山座　治義、増田　啓次、Huong Thi Nguyen Nguyen, Thanh Thi Mai Pham,　韓 旭、廣藤　雄太、野中　和明

ConBio 2017 生命科学合同年次大会  2017.12 

Understanding of neuropathology in Down syndrome: An in vitro study utilizing stem cells from exfoliated deciduous teeth. International conference

The 28th FUKUOKA INTERNATIONAL SYMPOSIUM ON PEDIATRIC / MATERNAL-CHILD HEALTH RESEARCH  2017.9 

Etiological research of congenital disorder with stem cells from human exfoliated deciduous teeth International conference

Hiroshi Sato, Pham Thi Mai Thanh, Xu Han, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Kazuaki Nonaka

The 27th FUKUOKA INTERNATIONAL SYMPOSIUM ON PEDIATRIC / MATERNAL-CHILD HEALTH RESEARCH  2017.8 

Increase of mitochondrial activity is crucial for the neuronal differentiation of stem cells from exfoliated deciduous teeth

Hiroki Kato, Thanh Thi Mai Pham, Xu Han, Yuta Hirofuji, Haruyoshi Yamaza, Keiji Masuda, Hiroshi Sato, Tomoaki Taguchi, Kazuaki Nonaka

2017.6 

Biological relationship between mitochondrial function and osteogenesis International conference

H. YAMAZA, H. KATO, H. XU, H. SATO, P. THANH, Y. HIROFUJI, K. MASUDA, K NONAKA

Gordon Research Conference, Musculoskeletal Biology & Bioengineering  2016.8 

Demand of mitochondrial activity in neuronal differentiation of stem cells from exfoliated deciduous teeth International conference

Hiroki Kato, Pham Thi Mai Thanh, Haruyoshi Yamaza, Keiji Masuda, Hiroshi Sato, Kazuaki Nonaka

Gordon Research Conference on Craniofacial Morphogenesis & Tissue Regeneration  2016.6 

Application of pulpal stem cell from exfoliated deciduous teeth to study the etiology of Rett Syndrome International conference

Hiroki KATO, Keiko WATANABE, Haruyoshi YAMAZA, Keiji MASUDA, Hiroshi SATO and Kazuaki NONAKA

"The Neurobiology of Parenting", Berzelius symposium 90  2015.8 

Translational research in developmental disorder by utilizing exfoliated deciduous teeth. International conference

Hiroki Kato, Keiko Watanabe, Haruyoshi Yamaza, Keiji Masuda, Hiroshi Sato, Kazuaki Nonaka

The 26th FUKUOKA INTERNATIONAL SYMPOSIUM ON PEDIATRIC / MATERNAL-CHILD HEALTH RESEARCH  2015.8 

日本ミトコンドリア学会

Screening of academic papers

Role(s)： Peer review

2017

事務局運営 International contribution

2016.8 - 2018.8

事務局運営

福岡国際母子総合研究シンポジウム 第14回市民公開講座  （ JR博多シティ　9階会議室1 ） 2016.8

Screening of academic papers

Role(s)： Peer review

2016

性染色体数異常における発達障害機序の解析　～乳歯歯髄幹細胞による橋渡し研究～

Grant number：19K10386  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(C)

細胞増殖から分化への転換に連関するミトコンドリア活性制御機構の解明

Grant number：19K10406  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(C)

酸化ストレスからみた口唇裂口蓋裂発症機序解明と予防法の開発

Grant number：16K11807  2016 - 2018

日本学術振興会  科学研究費助成事業  基盤研究(C)

乳歯で染色体異常疾患を克服するトランスレーショナル研究

Grant number：16K15839  2016 - 2018

科学研究費助成事業  挑戦的萌芽研究

研究助成金

2015

医学系研究助成

2015

ミトコンドリア凝集が引き起こす神経細胞死メカニズムの解明

Grant number：25860224  2013 - 2014

科学研究費助成事業  若手研究(B)

リサーチエクスポージャ3

2021.10 - 2021.12   Fall quarter

リサーチエクスポージャ2

2021.6 - 2021.8   Summer quarter

解剖学

2021.4 - 2022.3   Full year

リサーチエクスポージャ1

2021.4 - 2021.6   Spring quarter

解剖学

2020.10 - 2021.3   Second semester

リサーチエクスポージャ

2020.10 - 2021.3   Second semester

発生学

2020.4 - 2020.9   First semester

アーリーエクスポージャ

2020.4 - 2020.9   First semester

小児口腔医学

2019.4 - 2020.3   Full year

小児口腔医学演習

2019.4 - 2020.3   Full year

小児口腔医学

2019.4 - 2020.3   Full year

小児歯科学

2019.4 - 2020.3   Full year

Special Need Dentistry

2019.4 - 2019.9   First semester

Pediatric Dentistry

2019.4 - 2019.9   First semester

小児歯科学

2018.4 - 2019.3   Full year

小児口腔医学

2018.4 - 2019.3   Full year

小児口腔医学演習

2018.4 - 2019.3   Full year

Pediatric Dentistry

2018.4 - 2018.9   First semester

Special Need Dentistry

2018.4 - 2018.9   First semester

小児歯科学

2017.4 - 2018.3   Full year

小児口腔医学

2017.4 - 2018.3   Full year

小児口腔医学演習

2017.4 - 2018.3   Full year

Pediatric Dentistry

2017.4 - 2017.9   First semester

Special Need Dentistry

2017.4 - 2017.9   First semester

小児歯科学

2016.4 - 2017.3   Full year

小児口腔医学

2016.4 - 2017.3   Full year

小児口腔医学演習

2016.4 - 2017.3   Full year

Pediatric Dentistry

2016.4 - 2016.9   First semester

Special Need Dentistry

2016.4 - 2016.9   First semester

小児歯科学

2015.4 - 2016.3   Full year

小児口腔医学

2015.4 - 2016.3   Full year