Updated on 2025/06/30

Information

 

写真a

 
SAKAMOTO MIZUKI
 
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
Graduate School of Dental Science Department of Dental Science（Concurrent）
School of Dentistry Department of Dentistry（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426447
Profile
研究：シェーグレン症候群やIgG4関連疾患といった難治性唾液腺疾患の病態・発症のメカニズムについての研究や、多施設共同での「IgG4関連涙腺・唾液腺炎における顎下腺超音波検査の有用性」や「シェーグレン症候群の診断における口腔水分計の有用性」の検証を行っている。また、近年では口唇裂・口蓋裂の形態評価にも着目し、検討を行っている。 教育：大学院生の研究、研修医の診療、および歯学部学生の臨床実習指導を行っている。特に歯学部学生に関しては、臨床実習ライター長として、臨床予備実習・オスキー・臨床実習・アドバンストオスキーの分野内での統括を担当している。 臨床：九州大学病院顎口腔外科にて口腔外科全般の臨床を行っている。特に昨今は口唇口蓋裂や顎変形症に関して専門的に診療を行っている。2023年度は副病棟医長、2024年度は副外来医長、2025年度は病棟医長として病棟・外来マネージメントも行っている。
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Research Areas

  • Life Science / Oral pathobiological science

  • Life Science / Surgical dentistry

Degree

  • PhD

Research History

  • Kyushu University 歯学研究院 口腔顎顔面病態学講座 顎顔面腫瘍制御学分野 Assistant Professor 

    2023.4 - Present

Education

  • Kyushu University   歯学研究院  

    2015.4 - 2019.9

  • Kyushu University   歯学部   歯学科

    2008.4 - 2014.3

Research Interests・Research Keywords

  • Research theme： A study on newly treatment of Sjogren syndrome through autophagy pathway by Single-cell RNA sequencing

    Keyword： Autophagy, Single-cell RNA sequencing, Sjogren syndrome

    Research period： 2024.4 - 2027.3

  • Research theme： Multi-center study on usefulness of submandibular gland sonography for IgG4-IgG4-related dacryoadenitis and sialadenitis

    Keyword： 顎下腺超音波検査、多施設研究、セントラルレビュー

    Research period： 2023.4 - Present

  • Research theme： A study on a novel treatment of Sjogren syndrome forcusing on autophagy related molecules.

    Keyword： autophagy, Sjogren syndrome

    Research period： 2021.4 - 2024.3

  • Research theme： A study on the establishment of molecularly targeted therapy for IgG4-related disease focusing on scavenger receptor 'MARCO'.

    Keyword： Macrophage、IgG4-related dacryoadenitis and sialoadenitis

    Research period： 2019.9 - 2021.3

Awards

  • 唾液関連優秀論文

    2024.11   第3回 日本唾液ケア研究会学術集会   The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

    唾液に関連した国民の健康を支える研究者と、唾液医療を推進する歯科衛生士・栄養士の功績を称えたものに対する表彰

  • 優秀ポスター発表賞

    2023.11   第 68 回 (公社) 日本口腔外科学会総会・学術大会   ポスター『IgG4 関連疾患の免疫学的特徴とは? -IgG4 関連 疾患と mimicker との比較-』宮原 佑佳、森山 雅文、陳 鵠、金子 直樹、鎮守 晃、 坂本 瑞樹、他.

  • Rising Scientist賞

    2021.5   第75回 日本口腔科学会学術集会   ポスター発表「IgG4関連涙腺・唾液腺炎の診断における顎下腺超音波検査の有用性についての多施設研究 ～診断基準の改訂に向けて～」

  • 大会長賞

    2020.10   第33回日本口腔診断学会・第30回日本口腔内科学会・第13回日本口腔検査学会 合同学術集会   ポスター発表『シェーグレン症候群の診断における口腔水分計の有用性に関する検討』

  • 優秀ポスター賞

    2019.10   第64回 日本口腔外科学会総会・学術集会   ポスター発表『CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production』Masafumi Moriyama、Keigo Kubota、Noriko Ishiguro、Mizuki Sakamoto、他

  • 研究奨励賞

    2018.11   第46回 臨床免疫学会総会   ポスター『Clonalに増殖したCD4+CTLとTfh細胞はIgG4関連疾患の病態形成に関与する』 前原 隆、Matto Hamid、Emanuel Della Torre、柿添 乃理子、坂本 瑞樹、森山雅文、他

  • IADR Hatton Travel Awards

    2018.11   第66回 国際歯科研究学会(IADR)日本部会・総会   口演(日本代表選考会)『TLR8+CD68+ monocyte/macrophage contributes to the pathogenesis of Sjögren’s syndrome』M. SAKAMOTO、M. MORIYAMA、S. NAKAMURA

  • 優秀ポスター賞

    2018.5   第72回 口腔科学会学術集会   ポスター『シェーグレン症候群の病態形成におけるToll様受容体を介した自然免疫の関与』 坂本 瑞樹、森山 雅文、大山 恵子、他

  • Best award on International Youth Session Presentation

    2018.4   8. The 59th Congress of Korean Association of Oral & Maxillofacial Surgeons   口演『Involvement of innate immune responses in the pathogenesis of Sjögren’s syndrome via Toll like receptor 8』Mizuki SAKAMOTO、Masafumi MORIYAMA

  • 優秀演題賞

    2018.3   第11回 IgG４研究会   口演『IgG4 関連涙腺・唾液腺炎の診断における口唇腺生検および超音波検査の有用性』 坂本 瑞樹、森山 雅文、清水 真弓、他

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Papers

  • U-Shaped Osseous Release for Le Fort 1 Osteotomy: Potential Application to Superior Repositioning

    Shiokawa, H; Mochizuki, K; Hama, S; Miyahara, Y; Sakamoto, M; Kaneko, N; Ogata, K; Hayashida, JN; Kawano, S; Takahashi, I; Moriyama, M

    JOURNAL OF CRANIOFACIAL SURGERY   36 ( 4 )   1114 - 1118   2025.6   （ ISSN:1049-2275 eISSN:1536-3732 ）

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    Language：English   Publisher：Journal of Craniofacial Surgery  

    This study was performed to investigate the utility of U-shaped osseous release (USOR) for Le Fort 1 osteotomy as a novel surgical technique for superior repositioning. Thirty-six patients with jaw deformities were divided into 2 groups based on whether or not USOR was adopted (18 in the non-Adoption group and 18 in the adoption group). Maxillary surgical time, blood loss, and discrepancy from the planned amount of movement (anterior-posterior and superior-inferior directions) were compared between the 2 groups. Correlations between these items and the planned amount of superior-inferior movement were also examined. There were no significant differences in mean age, preset displacement, surgical time, blood loss, body mass index, or preset displacement error. However, a significant positive correlation was observed between the planned and actual amount of vertical movement only in the adoption group (P=0.0018). In addition, there was a tendency for the error (downward) to increase as the amount of upward movement increased in the non-Adoption group, but not the adoption group. These findings suggest that USOR may be a useful technique because it can safely and conveniently remove bony interference and can enable guidance to a more precise position, especially in cases with substantial superior movement.

    DOI： 10.1097/SCS.0000000000010915

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  • The 2023 revised diagnostic criteria for IgG4-related dacryoadenitis and sialadenitis

    Kanda, M; Nagahata, K; Moriyama, M; Takano, KI; Kamekura, R; Yoshifuji, H; Tsuboi, H; Yamamoto, M; Umehara, H; Umeda, M; Sakamoto, M; Maehara, T; Inoue, Y; Kubo, S; Himi, T; Origuchi, T; Masaki, Y; Mimori, T; Dobashi, H; Tanaka, Y; Nakamura, S; Takahashi, H

    MODERN RHEUMATOLOGY   35 ( 3 )   542 - 547   2025.5   （ ISSN:1439-7595 eISSN:1439-7609 ）

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    Language：English   Publisher：Modern Rheumatology  

    Objectives: For the diagnosis of immunoglobulin G4 (IgG4)-related dacryoadenitis and sialadenitis, either revised comprehensive diagnostic criteria or organ-specific diagnostic criteria for IgG4-related dacryoadenitis and sialadenitis in 2008 were applied; however, the collected knowledge for IgG4-related dacryoadenitis and sialadenitis required us to revise the criteria for IgG4-related dacryoadenitis and sialadenitis. Methods: The board member of Japanese Study Group for IgG4-related Dacryoadenitis and Sialadenitis revised the diagnostic criteria for IgG4-related dacryoadenitis and sialadenitis. We collected the clinical questions to be revised and performed a review of the literature. When the data were insufficient, additional data collection was performed. After the revision, public comments were collected. Results: The three major points were revised. (1) Asymmetric or under two pairs of dacryoadenitis and sialadenitis were included as IgG4-related dacryoadenitis and sialadenitis. (2) The thresholds of IgG4-positive cell infiltration were adjusted to an IgG4+/IgG+ ratio >0.4 and IgG4+ cells >10 per high power field. (3) The labial salivary gland biopsy was allowed to diagnose IgG4-related dacryoadenitis and sialadenitis Conclusions: The revised diagnostic criteria for IgG4-related dacryoadenitis and sialadenitis solved several issues with the previous criteria. It will improve the early diagnosis of IgG4-related dacryoadenitis and sialadenitis, especially in situations without enough resources for a biopsy.

    DOI： 10.1093/mr/roae096

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  • Possible involvement of Toll-like receptor 8-positive monocytes/macrophages in the pathogenesis of Sjögren's disease

    Yan, LJ; Miyahara, Y; Sakamoto, M; Kaneko, N; Chen, H; Sameshima, J; Kido, H; Yokomizo, S; Sueyoshi, T; Nagano, H; Ohyama, Y; Nakamura, S; Kawano, S; Moriyama, M

    FRONTIERS IN IMMUNOLOGY   15   1480675   2024.10   （ ISSN:1664-3224 ）

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    Language：English   Publisher：Frontiers in Immunology  

    Background: Sjögren’s disease (SjD) is an autoimmune disease marked by lymphocytic infiltration of salivary and lacrimal glands, leading to glandular dysfunction, where CD4-positive helper T (Th) cells and their cytokines are crucial in the pathogenesis. Recent studies have demonstrated that Toll-like receptors (TLRs), particularly those recognizing immune complexes containing DNA and RNA, contribute to Th cell activation in various autoimmune diseases. This study explores the expression and function of these TLRs in SjD. Methods: DNA microarray analysis of salivary gland tissue from six SjD patients and real-time PCR (n = 32) was used to identify overexpressed TLRs. Single-cell RNA sequencing (scRNA-seq) was performed using tissue lesions and integrated with published scRNA-seq data from tissues and peripheral blood mononuclear cells to examine gene expression in macrophages and monocytes. Finally, multi-color immunofluorescence staining was conducted to confirm TLR8 expression and function in SjD lesions (n = 19). Results: DNA microarray analysis revealed the up-regulation of TLR8, along with other TLRs and innate immune response genes in SjD. Real-time PCR showed significant up-regulation of TLR7 and TLR8. TLR8 up-regulated in both analyses. In scRNA-seq analysis, the TLR8-expressing cluster comprised macrophages and monocytes, which also produced T cell activation genes like CD86. TLR8-positive macrophages infiltrated inflammatory sites and frequently expressed CD86 in quantitative imaging approaches. Conclusions: These results suggest that infiltrating monocytes and macrophages may produce cytokines and chemokines through TLR8 stimulation, potentially enhancing B7 molecule expression, promoting the adaptive immune response, and contributing to SjD pathogenesis.

    DOI： 10.3389/fimmu.2024.1480675

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  • シェーグレン症候群の診断を目的とした口腔湿潤度測定の有用性　本測定法が診断基準に適用される可能性(The utility of oral moisture measurement for the diagnosis of Sjoegren's syndrome: Its potential application as a diagnostic criterion)

    Sakamoto Mizuki, Araki Jun, Moriyama Masafumi, Miyahara Yuka, Kawado Tatsuya, Yano Aiko, Koga Risako, Aoyagi Ryuichi, Murakami Yuka, Kaneko Naoki, Kawano Shintaro, Nakamura Seiji

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 5 )   743 - 748   2024.9   （ ISSN:2212-5558 ）

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    Language：English   Publisher：エルゼビア・ジャパン(株)  

    口腔水分計の製品であるムーカスIIIがシェーグレン症候群(SS)診断の助けになるか、唾液分泌量と同時測定することで比較検討した。2019～2021年に当院に紹介されたSS患者40名(女性38名、平均62.3±15.1歳)(罹患群)と健康対照者29名(女性28名、平均43.2±7.9歳)(対照群)を前向きに組み入れた。ムーカスIIIを使い舌背および頬粘膜で計測された湿潤値は、いずれも対照者に対し罹患群で有意に低下していた。唾液分泌量、特に吐唾法で測定された唾液分泌量は、舌背・頬粘膜の両湿潤値と有意に正相関していた。舌背湿潤値が示した診断能の感度は92.5%、特異度は68.9%、正確度は82.6%であり、頬粘膜湿潤値では同順で70.0%、82.8%、73.9%となった。舌背湿潤値は、口腔乾燥症の二次的な自覚症状(口腔疼痛、嚥下障害、味覚障害)の視覚的アナログスケールスコアと中等度に逆相関し、口腔乾燥症に直接関係する自覚症状(口腔乾燥および唾液生成量の減少)とは弱く逆相関していた。口腔水分計のムーカスIIIによる測定は、唾液分泌量の検査結果、および口腔の慢性自覚症状を正確に反映していた。本製品による測定法はSSの診断基準になると考えられた。

  • Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst

    Nakako Y., Hasegawa K., Fujii S., Kami Y., Sakamoto T., Sakamoto M., Moriyama M., Kurppa K.J., Heikinheimo K., Yoshiura K., Kawano S., Kiyoshima T.

    Pathology Research and Practice   260   155420   2024.8   （ ISSN:03440338 ）

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    Language：English   Publisher：Pathology Research and Practice  

    Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the OGTs, but it is even rarer and has a worse prognosis. The precise characteristics of PIOC, especially in immunohistochemical features and its pathogenesis, remain unclear. We characterized a case of PIOC arising from the left mandible, in which histopathological findings showed a transition from the odontogenic keratocyst to the carcinoma. Remarkably, the tumor lesion of this PIOC prominently exhibits malignant attributes, including invasive growth of carcinoma cell infiltration into the bone tissue, an elevated Ki-67 index, and lower signal for CK13 and higher signal for CK17 compared with the non-tumor region, histopathologically and immunohistopathologically. Further immunohistochemical analyses demonstrated increased expression of ADP-ribosylation factor (ARF)-like 4c (ARL4C) (accompanying expression of β-catenin in the nucleus) and yes-associated protein (YAP) in the tumor lesion. On the other hand, YAP was expressed and the expression of ARL4C was hardly detected in the non-tumor region. In addition, quantitative RT-PCR analysis using RNAs and dot blot analysis using genomic DNA showed the activation of Wnt/β-catenin signaling and epigenetic alterations, such as an increase of 5mC levels and a decrease of 5hmC levels, in the tumor lesion. A DNA microarray and a gene set enrichment analysis demonstrated that various types of intracellular signaling would be activated and several kinds of cellular functions would be altered in the pathogenesis of PIOC. Experiments with the GSK-3 inhibitor revealed that β-catenin pathway increased not only mRNA levels of ankyrin repeat domain1 (ANKRD1) but also protein levels of YAP and transcriptional co-activator with PDZ-binding motif (TAZ) in oral squamous cell carcinoma cell lines. These results suggested that further activation of YAP signaling by Wnt/β-catenin signaling may be associated with the pathogenesis of PIOC deriving from odontogenic keratocyst in which YAP signaling is activated.

    DOI： 10.1016/j.prp.2024.155420

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  • The clinical effectiveness of conservative surgical management in medication-related osteonecrosis of the Jaw(タイトル和訳中)

    Kakehashi Hiroe, Sakamoto Mizuki, Moriyama Masafumi, Goto Yuichi, Kitamura Ryoji, Ogata Kenichi, Nakamura Seiji, Kawano Shintaro

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 4 )   471 - 477   2024.7   （ ISSN:2212-5558 ）

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    Language：English   Publisher：エルゼビア・ジャパン(株)  

  • The utility of oral moisture measurement for the diagnosis of Sjögren’s syndrome: Its potential application as a diagnostic criterion Reviewed International journal

    Mizuki Sakamoto, Jun Araki, Masafumi Moriyama, Yuka Miyahara, Tatsuya Kawado, Aiko Yano, Risako Koga, Ryuichi Aoyagi, Yuka Murakami, Naoki Kaneko, Shintaro Kawano, Seiji Nakamura

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 5 )   743 - 748   2024.2   （ ISSN:2212-5558 eISSN:2212-5566 ）

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

    Objectives: To investigate the use of an oral moisture meter to aid in the diagnosis of Sjögren's syndrome (SS) by measuring the moisture values and salivary flow rate (SFR) simultaneously. Methods: The SFR and moisture values of the dorsum of the tongue and buccal mucosa were measured in 40 patients with SS and 29 healthy controls using an oral moisture meter. In addition, a visual analogue scale (VAS) was used to determine the degree of subjective oral symptoms (xerostomia, decreased saliva production, drinking during eating, oral pain, dysphagia, and dysgeusia). Results: The moisture values of the dorsum of the tongue and buccal mucosa were significantly lower in SS patients than in healthy subjects (both p < 0.01). SFR, especially when measured by the spitting test, correlated positively with the moisture values of the dorsum of the tongue (p < 0.0001) and buccal mucosa (p < 0.0003). Furthermore, the sensitivity, specificity, and accuracy of the oral moisture meter measurements of the dorsum of the tongue and buccal mucosa were 92.5%, 68.9%, and 82.6%, and 70.0%, 82.8%, and 73.9%, respectively. The moisture values of the dorsum of the tongue had a moderate negative correlation with the VAS scores of secondary subjective oral symptoms of xerostomia (oral pain, dysphagia, and dysgeusia), whereas a weak negative correlation was observed for subjective oral symptoms directly related to xerostomia (xerostomia and decreased saliva production). Conclusions: The oral moisture meter accurately reflected the results of the SFR tests and chronic subjective oral symptoms, and therefore might be a diagnostic criterion for SS.

    DOI： 10.1016/j.ajoms.2024.02.007

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  • The clinical effectiveness of conservative surgical management in medication-related osteonecrosis of the Jaw Reviewed International journal

    Hiroe Kakehashi, Mizuki Sakamoto, Masafumi Moriyama, Yuichi Goto, Ryoji Kitamura, Kenichi Ogata, Seiji Nakamura, Shintaro Kawano

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 4 )   471 - 477   2023.11   （ ISSN:2212-5558 eISSN:2212-5566 ）

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

    Objectives: Consensus has not yet been reached on the therapy for medication-related osteonecrosis of the jaw (MRONJ). We assessed the effectiveness of conservative surgical management, which involves removing the necrotic bone and performing a gingivectomy, followed by localized cleaning to facilitate the separation of the sequestrum. Additionally, we revalidated the treatment algorithm utilized by our department. Methods: We examined 160 patients diagnosed with MRONJ at three hospitals. The data for this study were collected retrospectively. These patients were followed up for a minimum of 2 years. Results: The outcome 2 years after starting conservative surgical management was: cure: 117 cases; improvement: 22 cases; unchanged: 12 cases; and deterioration: 9 cases. The cure rate was 72.3% and 83.0% at 2 and 5 years after therapy initiation, respectively, and significantly lower at age ≥ 74 years compared to age < 74 years (P < 0.001), with malignant tumour as the primary disease when compared to osteoporosis (P < 0.001), and with ≥ 4 years of administration compared to < 4 years (P = 0.0301). On multivariate analysis, the trigger (P < 0.05), primary disease (P = 0.001), and administration period (P < 0.01) were independent prognostic factors. Conclusions: Conservative surgical management is effective for MRONJ regardless of stage, especially in patients with age < 74 years, osteoporosis, and short drug-administration periods, and could become a first-line therapy for all stages.

    DOI： 10.1016/j.ajoms.2023.11.001

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  • , Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K Reviewed International journal

    Yuka Miyahara, Hu Chen, Masafumi Moriyama, Keita Mochizuki, Naoki Kaneko, A S M Rafiul Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, Masaki Yamauchi, Kenichi Ogata, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura

    Scientific reports   13 ( 1 )   19320   2023.11   （ ISSN:2045-2322 ）

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

    Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal T cells was considered to be crucial in the pathogenesis of OLP. Here, we selectively extracted the normal epithelium (NE) and lesional epithelium (LE) of buccal mucosa specimens from three patients with OLP by laser capture microdissection due to identify the pathogenic factors. Cathepsin K (CTSK) was identified as one of common upregulated genes in the LE by DNA microarray. Immunohistochemically, CTSK was distinctly detected in and around the LE, while it was rarely seen in the NE. Recent studies showed that CTSK enhanced Toll-like receptor 9 (TLR9) signaling in antigen-presenting cells, leading to Th17 cell differentiation. TLR9 expression mainly co-localized with CD123+ plasmacytoid dendritic cells (pDCs). The number of RORγt-positive cells correlated with that of CTSK-positive cells in OLP tissues. CD123+ pDCs induced the production of Th17-related cytokines (IL-6, IL-23, and TGF-β) upon stimulation with TLR9 agonist CpG DNA. Moreover, single cell RNA-sequencing analysis revealed that TLR9-positive pDCs enhanced in genes associated with Th17 cell differentiation in comparison with TLR9-negative pDCs. CTSK could induce Th17-related production of CD123+ pDCs via TLR9 signaling to promote the pathogenesis of OLP.

    DOI： 10.1038/s41598-023-46090-3

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  • Cytotoxic CD8(+) T cells may be drivers of tissue destruction in Sjogren's syndrome Reviewed International journal

    Kaneko N, Hu C, Perugino CA, Maehara T, Munemura R, Yokomizo S, Sameshima J, Diefenbach TJ, Premo KR, Chinju A, Miyahara Y, Sakamoto M, Moriyama M, Stone JH, Nakamura S.

    SCIENTIFIC REPORTS   2022.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-19397-w

  • CD163+ M2 macrophages promote fibrosis in IgG4-related disease via TLR7/IRAK4/NF-κB signaling. Reviewed International journal

    Akira Chinju, Masafumi Moriyama, Noriko Kakizoe-Ishiguro, Hu Chen, Yuka Miyahara, A S M Rafiul Haque, Katsuhiro Furusho, Mizuki Sakamoto, Kazuki Kai, Kotono Kibe, Sachiko Hatakeyama-Furukawa, Miho Ito-Ohta, Takashi Maehara, Seiji Nakamura

    Arthritis & rheumatology   2021.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/art.42043

  • シェーグレン症候群患者におけるM3 型ムスカリン受容体アゴニスト長期投与による治療効果の検討 Reviewed

    坂本 瑞樹、森山 雅文、清水 真弓、緒方 謙一、石黒 乃理子、鎮守 晃、太田 美穂、中村 誠司

    日本口腔内科学会雑誌   2020.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.6014/jjsom.26.77

  • 次世代シークエンス解析による木村氏病の病態解明 Th2型サイトカインを産生するIgE+c-kit+マスト細胞と特異なT細胞の関与 Reviewed

    宗村 龍祐, 前原 隆, 金子 直樹, 村上 祐香, 柿添 乃理子, 坂本 瑞樹, 望月 敬太, 森山 雅文, 川野 真太郎, 中村 誠司,

    日本口腔科学会雑誌   69 ( 2 )   151   2020.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease Reviewed International journal

    Cory A. Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J.H. Murphy, Musie Ghebremichael, Zachary S. Wallace, Marcy B. Bolster, Liam M. Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B. Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H. Stone, Shiv Pillai

    Journal of Allergy and Clinical Immunology   147 ( 1 )   368 - 382   2020.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jaci.2020.05.022

  • The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria Reviewed International journal

    Mizuki Sakamoto, Masafumi Moriyama, Mayumi Shimizu, Akira Chinju, Keita Mochizuki, Ryusuke Munemura, Keiko Ohyama, Takashi Maehara, Kenichi Ogata, Miho Ohta, Masaki Yamauchi, Noriko Ishiguro, Mayu Matsumura, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura

    Modern rheumatology   30 ( 2 )   379 - 384   2020.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/14397595.2019.1576271

  • Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling. Invited Reviewed International journal

    Noriko Ishiguro, Masafumi Moriyama, Katsuhiro Furusho, Sachiko Furukawa, Takuma Shibata, Yusuke Murakami, Akira Chinju, A S M Rafiul Haque, Yuka Gion, Miho Ohta, Takashi Maehara, Akihiko Tanaka, Masaki Yamauchi, Mizuki Sakamoto, Keita Mochizuki, Yuko Ono, Jun-Nosuke Hayashida, Yasuharu Sato, Tamotsu Kiyoshima, Hidetaka Yamamoto, Kensuke Miyake, Seiji Nakamura.

    Arthritis & rheumatology   72 ( 1 )   166 - 178   2020.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/art.41052

  • CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production. Reviewed International journal

    A S M Rafiul Haque, Masafumi Moriyama, Keigo Kubota, Noriko Ishiguro, Mizuki Sakamoto, Akira Chinju, Keita Mochizuki, Taiki Sakamoto, Naoki Kaneko, Ryusuke Munemura, Takashi Maehara, Akihiko Tanaka, Jun-Nosuke Hayashida, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura

    Scientific reports   9 ( 1 )   14611 - 14611   2019.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-51149-1

  • IgG4関連涙腺・唾液腺炎の診断における超音波検査および口唇腺生検の有用性

    坂本 瑞樹, 森山 雅文, 清水 真弓, 鎮守 晃, 望月 敬太, 宗村 龍祐, 大山 恵子, 前原 隆, 緒方 謙一, 太田 美穂, 山内 昌樹, 石黒 乃理子, 松村 万由, 中村 誠司

    日本口腔内科学会雑誌   24 ( 2 )   100 - 100   2018.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 上顎埋伏乳臼歯を含む歯原性線維腫の1例 Reviewed

    北村 亮二、松原 良太、川野 真太郎、坂本 瑞樹、清島 保、中村 誠司

    日本口腔外科学会雑誌   64 ( 9 )   528 - 533   2018.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • シェーグレン症候群の病態形態におけるToll様受容体を介した自然免疫の関与

    坂本 瑞樹, 森山 雅文, 大山 恵子, 田中 昭彦, 前原 隆, 緒方 謙一, 古川 祥子, 太田 美穂, 山内 昌樹, 石黒 乃理子, Haque A.S.M. Rafiul, 鎮守 晃, 望月 敬太, 松村 万由, 宗村 龍祐, 林田 淳之介, 中村 誠司

    日本口腔科学会雑誌   67 ( 2 )   189 - 190   2018.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • CD163(+) CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma. Reviewed International journal

    Keigo Kubota, Masafumi Moriyama, Sachiko Furukawa, Haque A. S. M. Rafiul, Yasuyuki Maruse, Teppei Jinno, Akihiko Tanaka, Miho Ohta, Noriko Ishiguro, Masaaki Yamauchi, Mizuki Sakamoto, Takashi Maehara, Jun-Nosuke Hayashida, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura.

    SCIENTIFIC REPORTS   7 ( 1 )   1755   2017.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-01661-z

  • Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus. Reviewed International journal

    Masaki Yamauchi, Masafumi Moriyama, Hayashida Jun-Nosuke, Takashi Maehara, Noriko Ishiguro, Keigo Kubota, Sachiko Furukawa, Miho Ohta, Mizuki Sakamoto, Akihiko Tanaka, Seiji Nakamura.

    PLoS One   12 ( 3 )   2017.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0173017

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Books

Presentations

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MISC

Professional Memberships

  • 日本口蓋裂学会

  • 日本口腔内科学会

  • 日本口腔科学会

  • 日本口腔外科学会

  • 日本シェーグレン症候群学会

Academic Activities

  • 運営スタッフ

    第76回 日本口腔科学会学術集会  （ Japan ） 2022.4

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    Type：Competition, symposium, etc. 

  • 運営スタッフ

    第35回日本口腔腫瘍学会総会・学術大会  （ Japan ） 2017.1

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    Type：Competition, symposium, etc. 

  • 運営スタッフ International contribution

    第63回国際歯科研究学会 日本部会総会・学術大会  （ Japan ） 2015.10

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    Type：Competition, symposium, etc. 

Research Projects

  • Ig患者レジストリを用いたIgG4関連涙腺・唾液腺炎の診断における顎下腺超音波の有用性

    2024.5

    九州大学大学院歯学研究院 口腔顎顔面病態学講座顎顔面腫瘍制御学分野 

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    Authorship：Coinvestigator(s) 

  • シングルセル解析によるシェーグレン症候群のオートファジーを介した治療法の開発

    Grant number：24K19996  2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    坂本瑞樹

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    Authorship：Principal investigator  Grant type：Scientific research funding

    シェーグレン症候群（SS）は、発症・病態形成にはTh細胞が重要な役割を果たしていることが示唆されている。近年、ステロイドに代わる新規治療薬が炎症性サイトカインを標的に開発されているが、SSに対する効果は限定的である。それはSSの病態形成にTh細胞から産生される多彩なサイトカインが関与しているためだと推察される。最近の報告では免疫システムの発生や恒常性の維持に重要な役割を果たすオートファジーの機能不全が炎症性サイトカインの過剰産生を促すことが報告されている。本研究では、SSにおけるオートファジー関連分子の発現と機能を解析し、サイトカイン産生を制御する上流分子を標的とした新規治療法の確立を目指す。

  • 難治性疾患政策研究事業　 「オールジャパン体制によるIgG4関連疾患の診断基準並びに診療指針の確立を目指す研究」班

    2023.4 - 2028.3

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    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 患者レジストリを用いたIgG4関連涙腺・唾液腺炎の診断における顎下腺超音波の有用性

    Grant number：23K09334  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    伊東 美穂, 森山 雅文, 坂本瑞樹

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    Grant type：Scientific research funding

    IgG4 関連疾患（IgG4-RD）は、高 IgG4 血症や多臓器に IgG4 陽性形質細胞の浸潤と著明な線維化を伴う腫脹を特徴とする本邦から提唱された新しい疾患概念である。 IgG4 関連涙腺・唾液腺炎（IgG4-DS）の診断においては、罹患臓器を全摘出することも多く、唾液分泌機能の低下や顔面神経障害などの合併症が生じるリスクを伴う。
    そこで本研究では、非侵襲性で繰り返し使用できる顎下腺超音波検査に着目し、IgG4-DS の診断および予後判定法の確立を目的に、希少疾患としては国内最大規模の患者レジストリデータを利用した検証を行い、診断への実用化を目指す。

  • オートファジー関連分子に着目したシェーグレン症候群の新規治療法の開発

    Grant number：21K17142  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    坂本 瑞樹

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    Grant type：Scientific research funding

    SSは涙腺・唾液腺が障害される臓器特異的自己免疫疾患であり、病態にはTh細胞が重要な役割を果たしている。炎症性サイトカインを標的とした生物学的製剤が開発され、一部の自己免疫疾患では治療効果が得られているがSSに対する効果は限定的である。それはSSの病態形成にTh細胞由来の多種のサイトカインが関与し、単一のサイトカインを阻害しても病態進展を阻止できないためだと推察される。またオートファジーの異常が炎症性サイトカインの過剰産生を促すことも報告されている。本研究ではSSにおけるオートファジー関連分子の発現・機能を解析し、サイトカイン産生を制御する上流分子を標的とした新規治療薬・診断法の確立を目指す。

    CiNii Research

  • オートファジー関連分子に着目したシェーグレン症候群の新規治療法の開発

    2021 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

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    Grant type：Scientific research funding

  • スカベンジャー受容体MARCOに着目したIgG4関連疾患の新規分子標的治療の確立

    Grant number：19K24097  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Educational Activities

  • 九州大学歯学部学生に対して、臨床実習ライター長として5-6年次の臨床予備実習・臨床実習を通して口腔外科領域の知識・手技に関して教育・指導を行っている。講座の大学院生には研究方法を教育し、主に難治性唾液腺疾患（シェーグレン症候群・IgG4関連涙腺・唾液腺炎）や口唇裂・口蓋裂についての研究を指導している。また、2023年度に九州大学病院歯科医師臨床研修指導歯科医資格を取得し、研修医教育にも従事し、学外では2023年度より福岡医健専門学校（歯科衛生士科）、2024年度より九州医療専門学校柔道整復師科の非常勤講師を務めている。

Class subject

  • 臨床予備実習

    2024.6 - 2025.8   Summer quarter

  • 臨床実習

    2024.4 - 2025.8   Full year

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2025  九州医療専門学校柔道整復師科   Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：木曜

  • 2025  福岡医健専門学校歯科衛生士科   Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：月曜

  • 2024  九州医療専門学校柔道整復師科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2024  福岡医健専門学校歯科衛生士科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  福岡医健専門学校歯科衛生士科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Other educational activity and Special note

  • 2024  Special Affairs  臨床実習に関わる評価者認定

    　詳細を見る

    2024年12月医療系大学間共用試験実施評価機構主催の歯学系診療参加型臨床実習後客観的臨床能力試験（CSC）認定評価者養成ワークショップに参加し、一斉技能試験(CSX）認定評価者として認定。
    2024年1月 OSCE評価者認定講習会に参加し、評価者として認定。
    2023年10月 2023年度九州大学病院歯科医師臨床研修指導歯科医講習会を受講し、臨床研修指導歯科医として認定。
    2023年4月 顎口腔外科　学生実習ライター長に着任
    2023年2月医療系大学間共用試験実施評価機構主催の歯学系診療参加型臨床実習後客観的臨床能力試験（CPX）認定評価者養成ワークショップに参加し、臨床能力試験臨床実地試験（CPX）認定評価者として認定。

Outline of Social Contribution and International Cooperation activities

  • ・熊本地震の震災復興支援活動　　熊本県（阿蘇郡南阿蘇村）、2016.5.8-15
    ・九州北部豪雨災害支援活動　　福岡県（朝倉郡東峰村）、2017.7.16-19

Social Activities

  • 九州北部豪雨災害復興支援活動.

    2017

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    九州北部豪雨災害復興支援活動.

  • 熊本地震の震災復興支援活動.

    2016

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    熊本地震の震災復興支援活動.

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Dentistry / Surgical Dentistry

Clinician qualification

  • Certifying physician

    日本口腔外科学会

  • Specialist

    日本口腔外科学会

Year of medical license acquisition

  • 2014