Faculty Profiles - SHINJO TAKANORI

Information

写真a

SHINJO TAKANORI

Organization

Faculty of Dental Science Department of Dental Science Assistant Professor
School of Dentistry Department of Dentistry（Joint Appointment）
Graduate School of Dental Science Department of Dental Science（Joint Appointment）
Graduate School of Dental Science （Joint Appointment）

Contact information

Tel

0926426358

Profile

Outline of research ・Basic studies in the effect of periodontal disease on systemic disease and health. ・Basic studies in the pathogenic role of obesity/diabetes in periodontal disease. Education ・Periodontal therapy

Homepage

http://www.dent.kyushu-u.ac.jp/perio/

External link

Degree

Ph.D

Research History

2013年４月から2014年3月まで広島大学病院歯科保存診療科診療医（医員）として従事した。 2016年5月から2019年5月まで米国Joslin Diabetes Centerへ留学した。

Research Interests・Research Keywords

Research theme：The pathogenetic role of insulin resistance in Schwann cells on diabetes-related periodontitis

Keyword：diabetes-related periodontitis, Schwann cells, insulin resistance

Research period： 2024.3 - 2027.3
Research theme：The pathological role of adipose tissue neutrophils activated by periodontitis

Keyword：periodontitis, adipose tissue, neutrophil, obesity, diabetes

Research period： 2024.2 - 2026.1
Research theme：Investigation of the molecular basis of enhancement in wound healing from periodontitis using insulin action sensitizing agent

Keyword：insulin resistance, diabetes, periodontitis, wound healing

Research period： 2023.4 - 2025.3
Research theme：The association of periodontitis in the development and progression of NASH and NAHS-related HCC

Keyword：periodontitis, NASH, HCC

Research period： 2022.4 - 2025.3
Research theme：Investigation into the pathogenesis of diabetes-associated periodontitis by integrated omics analysis

Keyword：diabetes, periodontitis, metabolomics, proteomics, RNA-sequence

Research period： 2020.11 - 2024.3
Research theme：Development of a novel drug for prevention of periodontitis based on SPOCK-1 protein

Keyword：periodonititis, drug-induced gingival overgrowth, EMT, SPOCK-1

Research period： 2020.4 - 2023.3
Research theme：The investigation into potential mechanisms of the association between periodontal disease and diabetic kidney disease

Keyword：Periodontal disease, diabetic kidney disease, periodontal medicine

Research period： 2020.4 - 2023.3
Research theme：The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis

Keyword：inflammation, insulin resistance, obesity, diabetes, periodontitis

Research period： 2019.4 - 2022.3
Research theme：Investigation into the effect of periodontitis-induced Th17 immune respose on adipose tissue inflammation.

Keyword：chronic inflammation, periodontai disease, Th17 cell, adipose tissue

Research period： 2015.4 - 2016.4
Research theme：Investigation into molecule mechanism of anti-infllammatory effect of SK-0403 via DPP4 inhibition.

Keyword：anti-inflammatory effect, diabetes, macrophage, adipocyte

Research period： 2013.8 - 2015.3

Awards

令和5年度九大歯学優秀研究者賞(FWCI部門)

2024.2 九州大学歯学部

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過去5年間の一連の研究に関する原著論文のFWCI
九大歯学優秀研究者賞(臨床教員・IF部門)

2022.10 九州大学歯学部 JCI insight Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy.
第37回「歯科医学を中心とした総合的な研究を推進する集い」優秀発表賞

2022.3 日本歯科医学会発表演題：歯周炎による糖尿病性腎症増悪メカニズムの解明
79th American Diabetes Association Scientific Session Young Investigator Travel Grant Award

2019.6 American Diabetes Association

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Pyruvate kinase M2 overexpression in podocytes ameliorates nephropathy in diabetic mice
Elevated expression of pyruvate kinase isoform M2 (PKM2) in the renal glomeruli of people with diabetes is associated with protection from nephropathy even with hyperglycemia. Furthermore, systemic use of PKM2 activators (TEPP46) can prevent or reverse glomerular pathology in diabetic mice. To determine specifically the role of PKM2 in the development or progression of diabetic glomerulopathy, we generated transgenic mice overexpressing PKM2 specific targeted to the podocytes (PPKM2Tg mice) driven by the podocin promoter. Analysis of the glomeruli from these mice showed 1.5-fold increases in mRNA and protein levels without changes in PKM1, compared to wild type (WT) littermates (p<0.05). Pyruvate kinase (PK) activity in the glomeruli of the PPKM2Tg mice was increased by 40% compared to those in WT mice (p<0.05). Diabetes was induced in eight-week-old WT and PPKM2Tg mice by streptozotocin (STZ) and maintained with sustained glucose levels >400mg/dL for 7 months. Diabetic PPKM2Tg mice showed significantly lower urinary albumin-creatinine ratio (ACR) and kidney weight-body weight ratios (p<0.05) compared to diabetic WT mice even with similar hyperglycemia. PK activity was lowered in the glomeruli of diabetic WT mice by 30%, whereas levels in diabetic PPKM2Tg mice were comparable to non-diabetic WT mice. For renal pathology, diabetic PPKM2Tg mice exhibited smaller glomeruli compared to diabetic WT mice. Similarly, expressions of inflammatory genes including TNF and MCP-1, and fibrotic genes including fibronectin and TGF-1 were downregulated in the glomeruli of diabetic PPKM2Tg mice compared to diabetic WT mice. In contrast, mitochondrial genes such as PGC-1α, Opa1, and cytochrome b in the glomeruli of diabetic PPKM2Tg mice were significantly upregulated as compared to diabetic WT mice. These findings strongly suggest that upregulation or activation of PKM2 and glycolysis may improve mitochondrial function in podocytes and prevent the progression of diabetic nephropathy.
79th American Diabetes Association Scientific Session President Select Abstract

2019.6 American Diabetes Association

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Pyruvate kinase M2 overexpression in podocytes ameliorates nephropathy in diabetic mice
Elevated expression of pyruvate kinase isoform M2 (PKM2) in the renal glomeruli of people with diabetes is associated with protection from nephropathy even with hyperglycemia. Furthermore, systemic use of PKM2 activators (TEPP46) can prevent or reverse glomerular pathology in diabetic mice. To determine specifically the role of PKM2 in the development or progression of diabetic glomerulopathy, we generated transgenic mice overexpressing PKM2 specific targeted to the podocytes (PPKM2Tg mice) driven by the podocin promoter. Analysis of the glomeruli from these mice showed 1.5-fold increases in mRNA and protein levels without changes in PKM1, compared to wild type (WT) littermates (p<0.05). Pyruvate kinase (PK) activity in the glomeruli of the PPKM2Tg mice was increased by 40% compared to those in WT mice (p<0.05). Diabetes was induced in eight-week-old WT and PPKM2Tg mice by streptozotocin (STZ) and maintained with sustained glucose levels >400mg/dL for 7 months. Diabetic PPKM2Tg mice showed significantly lower urinary albumin-creatinine ratio (ACR) and kidney weight-body weight ratios (p<0.05) compared to diabetic WT mice even with similar hyperglycemia. PK activity was lowered in the glomeruli of diabetic WT mice by 30%, whereas levels in diabetic PPKM2Tg mice were comparable to non-diabetic WT mice. For renal pathology, diabetic PPKM2Tg mice exhibited smaller glomeruli compared to diabetic WT mice. Similarly, expressions of inflammatory genes including TNF and MCP-1, and fibrotic genes including fibronectin and TGF-1 were downregulated in the glomeruli of diabetic PPKM2Tg mice compared to diabetic WT mice. In contrast, mitochondrial genes such as PGC-1α, Opa1, and cytochrome b in the glomeruli of diabetic PPKM2Tg mice were significantly upregulated as compared to diabetic WT mice. These findings strongly suggest that upregulation or activation of PKM2 and glycolysis may improve mitochondrial function in podocytes and prevent the progression of diabetic nephropathy.
日本歯周病学会研究者育成ファンド

2018.3 日本歯周病学会歯肉におけるインスリン抵抗性が歯周炎増悪に寄与するメカニズムの解明
103rd American Academy of Periodontology annual meeting Research Forum Poster Session Award (Basic Science)

2017.9 American Academy of Periodontology
日本歯周病学会奨励賞

2014.5 日本歯周病学会 Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing inslulin-induced IRS-1 phosphorylation and metabolic actions.

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Papers

The bidirectional association between diabetes and periodontitis, from basic to clinical Reviewed

Takanori Shinjo, Fusanori Nishimura

Japanese Dental Science Review 2024.12

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Language：Others Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jdsr.2023.12.002
Endothelial insulin resistance exacerbates experimental periodontitis Reviewed International journal

Tatsuro Zeze, @Takanori Shinjo, Kohei Sato, Yuki Nishimura, Mio Imagawa, Shuang Chen, Al-kafee Ahmed, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Kyoungmin Park, George L King, Fusanori Nishimura

Journal of Dental Research 2023.6

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Language：English Publishing type：Research paper (scientific journal)
Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice. Reviewed International journal

@Takanori Shinjo, Satoru Onizuka, Yumi Zaitsu, Atsushi Ishikado, Kyoungmin Park, Qian Li, Hisashi Yokomizo, Tatsuro Zeze, Kohei Sato, Ronald St-Louis, Jialin Fu, Wu I-Hsien, Koji Mizutani, Hatice Hasturk, Thomas E Van Dyke, Fusanori Nishimura, George L King

Diabetes 2023.4

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Language：English Publishing type：Research paper (scientific journal)
miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation. Reviewed International journal

Rongzhi Li, Tomomi Sano, Akiko Mizokami, Takao Fukuda, ＠Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Yusuke Nakatsu, Yusuke Sotomaru, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura

2022.12

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Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression. Reviewed International journal

Yukari Watanabe, Takao Fukuda, Chikako Hayashi, Yuki Nakao, Masaaki Toyoda, Kentaro Kawakami, ＠Takanori Shinjo, Misaki Iwashita, Hiroaki Yamato, Karen Yotsumoto, Takaharu Taketomi, Takeshi Uchiumi, Terukazu Sanui, Fusanori Nishimura

2022.8

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XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis Reviewed International journal

Yuki Nishimura, Misaki Iwashita, Masato Hayashi, ＠Takanori Shinjo, Yukari Watanabe, Tatsuro Zeze, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomomi Sano, Tomoichiro Asano, Fusanori Nishimura

2022.7

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Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy Reviewed International journal

Jialin Fu*, Takanori Shinjo*, Qian Li, Ronald St-Louis, Kyoungmin Park, Marc G Yu, Hisashi Yokomizo, Fabricio Simao, Qian Huang, I-Hsien Wu, George L King *: Co-first

JCI Insight 7 ( 5 ) e155260 2022.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1172/jci.insight.155260
Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration. Reviewed International journal

Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL.

J Periodontol. 90 ( 6 ) 565 - 575 2019.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/JPER.18-0735.
IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes. Reviewed International journal

477 ( 2 ) 241 - 246 2016.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2016.06.049.
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice. Reviewed International journal

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T.

Diabetology and Metabic Syndrome 7 ( 50 ) 2015.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13098-015-0047-y
DPP-4 inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. Reviewed International journal

309 ( 3 ) E214 - E223 2015.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1152/ajpendo.00553.2014
Par14 protein associates with insulin receptor substrate 1(IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. Reviewed International journal

Shinjo T, Zhang J, Nakatsu Y, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F,Katagiri H, Takahashi S, Kurihara H, Ushida T, Asano T.

Journal of Biological Chemistry 288 ( 28 ) 20692 - 20701 2013.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1074/jbc.M113.485730
Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis. Reviewed International journal

Kyoungmin Park, Qian Li, Matthew D Lynes, Hisashi Yokomizo, Ernesto Maddaloni, Takanori Shinjo, Ronald St-Louis, Qin Li, Sayaka Katagiri, Jialin Fu, Allen Clermont, Hyunseok Park, I-Hsien Wu, Marc Gregory Yu, Hetal Shah, Yu-Hua Tseng, George L King

Circulation Research 2022.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1161/CIRCRESAHA.121.319582.
Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain Reviewed International journal

Masato Hayashi, Misaki Iwashita, Yuki Nishimura, Takanori Shinjo, Tomomi Sano, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Fusanori Nishimura

BMJ Open Diabetes Research and Care 9 ( 1 ) 2021.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1136/bmjdrc-2020-001871
Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss Invited Reviewed International journal

2021.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.actbio.2020.12.046.
SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism. International journal

Rehab Alshargabi, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Tomomi Sano, Yuki Nishimura, Masato Hayashi, Tatsuro Zeze, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

Biochemical and biophysical research communications 2020.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2020.09.129
SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth Reviewed International journal

Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Aiko Takano, Taiki Sanada, Misaki Iwashita, @Takanori Shinjo, Takao Fukuda, Terukazu Sanui, Shosei Kishida, Fusanori Nishimura

Scientific reports 2020.7

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Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues. Reviewed International journal

Taiki Sanada, Tomomi Sano, Yusuke Sotomaru, Rehab Alshargabi, Yosuke Yamawaki, Akiko Yamashita, Hiroaki Matsunaga, Misaki Iwashita, @Takanori Shinjo, Takashi Kanematsu, Tomoichiro Asano, Fusanori Nishimura

Biochemistry and biophysics reports 22 100757 - 100757 2020.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrep.2020.100757
Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages Reviewed International journal

Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, @Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura

Frontiers in Immunol 11 709 2020.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fimmu.2020.00709
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Reviewed International journal

Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL.

Diabetes Care 42 ( 7 ) 1263 - 1273 2019.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2337/dc18-2585.
Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Reviewed International journal

Takano A., Fukuda T., Shinjo T., Iwashita M., Matsuzaki E., Yamamichi K., Takeshita M., Sanui T., Nishimura F

Metabolism 69 157 - 260 2019.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.metabol.2017.01.006.
Epicatechin downregulated adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance. Invited Reviewed International journal

Sano T., Nagayasu S., Suzuki S., Iwashita M., Yamashita A., Shinjo T., Sanui T., Kushiyama A., Kanematsu T., Asano T., Nishimura F.

Nutr Metab Cardiovasc Dis 37 ( 30 ) 249 - 259 2019.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.numecd.2016.11.008
Metabolic endotoxemia-activated macrophages promote pancreatic β cell death via IFNβ-Xaf1 pathway. Reviewed International journal

50 ( 2 ) 160 - 167 2018.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0043-121467
Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Reviewed International journal

Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL.

Arterioscler Thromb Vasc Biol. 38 ( 1 ) 92 - 101 2018.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1161/ATVBAHA.117.310291.
Adipose tissue complement factor B promotes adipocyte maturation. Reviewed International journal

Matsunaga H, Iwashita M, Shinjo T, Yamashita A, Tsuruta M, Nagasaka S, Taniguchi A, Fukushima M, Watanabe N, Nishimura F.

Biochem Biophys Res Commun 495 ( 1 ) 740 - 748 2018.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2017.11.069.
Protection from diet-induced obesity and insulin resistance in mice lacking CCL-19–CCR7 signaling. Reviewed International journal

23 ( 7 ) 1460 - 1471 2015.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/oby.21127.
Interactive roles of gut microbiota and gastrointestinal motility in the development of inflammatory disorders. Reviewed International journal

Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T.

Inflammation and Cell Signaling 2 ( 1 ) 2015.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.14800/ics.643
Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. Reviewed International journal

Okubo H, Nakatsu Y, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T.

American Journal of Physiology Gastrointestinal Liver and Physiology 308 ( 2 ) G151 - G158 2015.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1152/ajpgi.00198.2014
The inflammation-lipocalin2 axis may contribute to the development of chronic kidney disease. Reviewed International journal

Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F.

Nephrology Dialysis Transplantation 29 ( 3 ) 611 - 618 2014.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/ndt/gft449
Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice. Reviewed International journal

Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T.

Adipocyte 2 ( 1 ) 28 - 32 2013.1

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Books

月刊糖尿病147号肥満・糖尿病・歯周病・

＠新城尊徳（ Role： Joint author）

医学出版 2022.12

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Language：Japanese Book type：Scholarly book
糖尿病プラクティス11・12月号

＠新城尊徳（ Role： Joint author）

2022.11

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Language：Japanese Book type：Scholarly book
糖尿病プラクティス9・10月号

＠新城尊徳（ Role： Joint author）

医歯薬出版株式会社 2022.9

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Language：Japanese Book type：Scholarly book
糖尿病プラクティス7・8月号

＠新城尊徳（ Role： Joint author）

医歯薬出版株式会社 2022.7

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Language：Japanese Book type：Scholarly book
糖尿病・内分泌代謝科（特集）口腔ケアと生活習慣病Up-to-date 歯周病と糖尿病及び糖尿病合併症との関連性)

@新城尊徳（ Role： Joint author）

科学評論社 2022.6

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Language：Japanese Book type：Scholarly book
ファーマスタイル　歯周病を知る－知っておきたい歯周病の知識と全身疾患との関連

@新城尊徳、@大山順子（ Role： Joint author）

株式会社日本アルトマーク 2022.6

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Language：Japanese Book type：Scholarly book
糖尿病プラクティス9・10月号

新城尊徳

医歯薬出版株式会社 2020.9

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Language：Others
ヒト常在菌叢と生理機能・全身疾患

新城尊徳, 西村英紀

シーエムシー出版 2020.8

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Language：Others
Diabetes and periodontitis.

Shinjo T., Nishimura F.（ Role： Joint author）

Springer 2017.1

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Language：English Book type：Scholarly book

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Presentations

実験的歯周炎によって2型糖尿病モデルKK-Ayマウスにおける腎症は増悪する

＠新城尊徳, 佐藤晃平, 横溝久, 瀬々起朗, 今川澪, 岩下未咲, 山下明子, 西村英紀

第66回日本糖尿病学会年次学術集会 2023.6

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Event date： 2023.6

Language：Japanese

Venue：鹿児島県民交流センター、城山ホテル鹿児島 Country：Japan
Insulin Resistance and Obesity-Related Periodontitis: a Novel Molecular Basis and Potential Therapeutic Targets Invited International conference

2022 IADR/APR General Session & Exhibition 2022.6

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Event date： 2022.6

Language：Japanese Presentation type：Symposium, workshop panel (public)

Country：Japan
糖尿病性腎症モデルマウスを用いた歯周病による腎症増悪機構の解明 Invited

@新城尊徳, 佐藤晃平, 瀬々起朗, 西村英紀

第76回日本口腔口腔科学会学術集会 2022.6

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Event date： 2022.4

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：福岡国際会議場 Country：Japan
Insulin resistance in gingival fibroblasts exacerbates experimental periodontitis in mice International conference

Takanori Shinjo@, Thomas Van Dyke@, Hatice Hasturk@, George L King@, Fusanori Nishimura@

2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Country：United States
長期生存1型糖尿病患者群における歯周病重症度と糖尿病合併症との相関

@新城尊徳、西村英紀

2020年度春季日本歯周病学会学術大会 2020.7

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Event date： 2020.7

Language：Japanese

Country：Japan

【背景】糖尿病患者は健常人と比して歯周病の罹患率が高く、病態が重症化しやすい。米国ジョスリン糖尿病センターにおいて50年以上の長期生存1型糖尿病患者(Medalist)を対象にした疫学研究より、Medalistは腎症、網膜症、心血管疾患などの糖尿病合併症罹患率が一般の糖尿病患者群よりも低いことが分かっている。今回、Medalistを対象に歯周病重症度の評価及び重症度と糖尿病合併症罹患率との相関を解析することとした。【方法】170名(平均年齢64.6±6.9歳)を対象にCenters for Disease Control/American Academy of Periodontologyの診断基準に従い歯周病重症度を診断し、年齢・性別などの人口統計要因、各種血液データとの相関を検討した。【結果】Medalistの重度歯周炎罹患率は13.5%と、米国国民健康調査より算出した同年齢層の糖尿病患者のものより低値だった。歯周炎重症度は年齢、性別(男)、糖尿病発症年齢および血清IL-6濃度・P. gingivalis (Pg)抗体価、心血管疾患の既往と正の相関を示し、血清C-ペプチド濃度は重症度と負の相関を示した。さらに、血清C-ペプチドが検出限界値未満の群は以上の群より平均ポケット深さやCALが高値であった。Pg血清抗体価はMedalistで心血管イベント既往歴と相関した。【考察】Medalistは高血糖があるにも関わらず、歯周病の進行に対しても保護的であった。内因性インスリン関連因子が糖尿病状態における歯周炎増悪に抑制的に作用する可能性が示唆された。
The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis. Invited International conference

@Takanori Shinjo

The 105th American Academy of Periodontology annual meeting 2019.11

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Event date： 2019.11

Language：English Presentation type：Oral presentation (general)

Country：United States
歯肉におけるインスリン抵抗性は歯周炎を増悪する

新城尊徳、西村英紀

2019年度秋季日本歯周病学会 2019.10

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Event date： 2019.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：西日本国際展示場・北九州国際展示場 Country：Japan

【背景】歯周病は糖尿病の第6の合併症として広く認知され高血糖が歯周炎の増悪に関わることが示唆されているが、肥満が糖尿病と独立して歯周炎の重症化に関わる可能性も指摘されている。近年の報告より、肥満・糖尿病ラットでは歯肉においてもインスリン抵抗性が惹起することが明らかとなっている。そこで、組織特異的インスリン受容体(IR)欠損マウスを用いて、歯周組織局所のインスリン抵抗性が肥満・糖尿病関連性歯周炎に及ぼす影響を検討することとした。【方法】血管平滑筋マーカーSM22αプロモーター下Cre発現マウスとIR-floxedマウスを交配し、血管平滑筋特異的IR欠損(SMIRKO)マウスを得た。また同腹仔野生型(WT)に通常食(RD)および高脂肪食負荷(HFD)を10週間行った。14週齢の各雄性マウスの第2臼歯に7-0絹糸を結紮し、実験的歯周炎を惹起した。【結果】WT(RD)と比較して、歯肉中IR発現はSMIRKOマウスで約70%、HFDマウスで約50%低下しており、両マウス歯肉ともインスリン誘導性Aktリン酸化の有意な抑制が見られ、さらに実験的歯周炎惹起後14日目では歯肉のTNFα、IL-1β、IL-17といった炎症性サイトカイン発現、歯槽骨吸収および破骨細胞形成が有意に上昇・亢進した。興味深いことに、SMIRKO・HFDマウスでは実験的歯周炎惹起後4日目の歯肉中の好中球数はWT(RD)マウスより有意に少なかったが、14日目では増加していた。【考察】歯肉におけるインスリン抵抗性は、歯周感染に対する好中球浸潤の遅延を起こし炎症反応が遷延化することで、歯周炎増悪に寄与することが示唆された。
The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis Invited International conference

@Takanori Shinjo

The 9th Japan-Thailand-Korea Joint Symposium 2019.10

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Event date： 2019.10

Language：English Presentation type：Symposium, workshop panel (public)

Country：Korea, Republic of
Insulin-regulation of CXCL1 expression is important for neutrophil recruitments, periodontitis, and poor wound healing in diabetes. International conference

@Takanori Shinjo, Qian Li, Atsushi Ishikado, Park Kyoungmin, Ronald St-Louis, @Hisashi Yokomizo, Fu Jialin, Marc Yu, Haiyan Wang, Hatice Hasturk, Thomas E Van Dyke, George L King

79th American Diabetes Association Scientific Sessions 2019.6

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Event date： 2019.6

Language：English

Country：United States
Pyruvate kinase M2 overexpression in podocytes ameliorates nephropathy in diabetic mice. International conference

@Takanori Shinjo, Ronald St-Louis, Jialin Fu, Park Kyoungmin, Qian Li, @Hisashi Yokomizo, Marc Yu, Haiyan Wang, Aimo Kannt, Thorsten Sadowski and George L. King

79th American Diabetes Association Scientific Sessions 2019.6

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Event date： 2019.6

Language：English

Country：Japan
Protection from periodontal disease among insulin-dependent type 1 diabetic patients with disease duration of 50 years or longer-The Joslin 50-Year Medalist Study. International conference

@Shinjo T, Ishikado A, Hasturk H, Tinsley L, Pober D, Wu IH, Van Dyke TE, Genco R, King GL

78th American Diabetes Association Scientific Sessions 2018.6

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Event date： 2018.6

Language：English

Country：United States
Depletion of Insulin receptor beta in gingiva exacerbates alveolar bone loss in mice model of experimental periodontitis. International conference

@Shinjo T, Ishikado A, Park K, Li Q, St-Louis R, @Yokomizo H, Alves V, Kantarci A, Van Dyke TE, King GL

103rd American Academy of Periodontology annual meeting 2017.9

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Event date： 2017.9

Language：English

Country：United States
DPP4 inhibitor anagliptin exerts anti-inflammatory effect on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. International conference

新城尊徳

2015.7

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Event date： 2015.6 - 2015.7

Language：English Presentation type：Symposium, workshop panel (public)

Venue：Pennsilvania University, America Country：United States
DPP4阻害薬anagliptinはマクロファージ-脂肪細胞共培養系およびマウス肝臓のLPS誘導性炎症反応を抑制する

新城尊徳

第29回日本糖尿病合併症学会 2014.10

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Event date： 2014.10

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：都市センターホテル、東京 Country：Japan
DPP-4 Inhibitor Anagliptin exerts Anti-inflammatory Effects on Macrophages, Adipocytes, and Mouse Liver by suppressing LPS-induced NF-κB Activation. International conference

新城尊徳

第74回アメリカ糖尿病学会 2014.6

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Event date： 2014.6

Language：English Presentation type：Symposium, workshop panel (public)

Venue：サンフランシスコ、アメリカ Country：United States
DPP4阻害薬anagliptinは、活性化マクロファージおよびマクロファージ共培養下脂肪細胞の炎症反応を抑制する.

新城尊徳

第57回日本糖尿病学会年次学術集会 2014.5

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Event date： 2014.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪国際会議場、大阪 Country：Japan
歯周病による糖尿病性腎症の増悪に関する新たな分子メカニズム Invited

新城尊徳, 佐藤晃平, 瀬々起朗, Ahmed Al-kafee, 大塚穂佳, 岩下未咲, 西村英紀

第14回日本腎臓リハビリテーション学会学術集会ジョイントシンポジウム14 多職種コラボレーションで支える腎疾患患者の健口とは 2024.3

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Event date： 2024.3

Language：Japanese

Country：Other
セッション3 食事と口腔衛生から考える糖尿病「歯周病と糖尿病の相互関係」 Invited

新城尊徳

第6回日本抗加齢医学会九州地方会学術総会 2024.1

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Event date： 2024.1

Language：Japanese

Country：Other
An emerging mechanism in diabetes-related periodontitis: the pathogenic role of insulin resistance in periodontal tissue Invited

2023.11

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Event date： 2023.11

Language：English

Country：Other

An emerging mechanism in diabetes-related periodontitis: the pathogenic role of insulin resistance in periodontal tissue
糖尿病関連歯周炎の新たな病態基盤～インスリン抵抗性の観点から Invited

新城尊徳

第38回日本糖尿病合併症学会シンポジウム6.歯周病を取り巻く最新の話題と医科歯科連携 2023.10

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Event date： 2023.10

Language：English

Country：Other
九大歯学優秀研究者賞受賞講演 Invited

新城尊徳

2022年度 KOB (Kyudai Oral Biosciences)・OBT・DDR 合同国際シンポジウム 2022.10

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Event date： 2022.10

Language：English

Country：Other
歯周病と糖尿病を関連づける新たなキーファクター「インスリン作用」～ボストンでの3年間の留学生活 Invited

@新城尊徳

2021年度春季日本歯周病学会学術大会　若手研究者の集い 2021.5

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Event date： 2021.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン Country：Japan

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MISC

Insulin Resistance Is an Alternative, Novel Risk Factor for Diabetes-Associated Periodontitis Reviewed

Takanori Shinjo, Tatsuro Zeze

Current Oral Health Reports 2023.8

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Language：Others

DOI： 10.1007/s40496-023-00345-0

Professional Memberships

Japan Society of Periodontology
Japan Society of Conservative Dentistry
Japan Society of Diabetic Complications
JAPANESE SOCIETY OF PERIODONTOLOGY
THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY
日本糖尿病合併症学会

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Academic Activities

Screening of academic papers

Role(s)： Peer review

2023

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：5

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：0
Screening of academic papers

Role(s)： Peer review

2022

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：0
Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：4

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：0

Other

Mary K. Iacocca Foundation Research fellowship

2018.5
平成２７年度　サンスター財団金田博夫研究助成基金

2016.5

Research Projects

PGD2シグナリング経路に着目した歯周炎が糖尿病性腎症を増悪する分子機序の解明

Grant number：23K09170 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
歯周炎に応答した脂肪組織好中球活性化の病的意義

2023 - 2025

公益財団法人アステラス病態代謝研究会研究助成金

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Authorship：Principal investigator Grant type：Contract research
糖尿病関連歯周炎における神経鞘細胞のインスリン抵抗性の意義

2023 - 2025

一般財団法人貝原守一医学振興財団令和5年度研究助成金

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Authorship：Principal investigator Grant type：Contract research
歯周炎による糖尿病性腎症増悪における腎糸球体H-PGDS関連脂質メディエーターの役割の解明

2023 - 2024

公益財団法人鈴木謙三記念医科学応用研究財団令和５年度調査研究助成

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Authorship：Principal investigator Grant type：Contract research
メサンギウム細胞H-PGDSを軸とした歯周炎症-糖尿病性腎症連関メカニズムの解明

2023 - 2024

公益財団法人金原一郎記念医学医療振興財団第38回基礎医学医療研究助成金

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Authorship：Principal investigator Grant type：Contract research
NASH 関連肝がんの発症･進展と歯周炎の関連における分子基盤の解明

2023 - 2024

公益財団法人新日本先進医療研究財団令和5年度(第9回）研究助成金

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Authorship：Principal investigator Grant type：Contract research
軽度肥満（内臓脂肪炎症モデル）マウスを用いた歯周炎-DKD連関機構の解明

2022.10 - 2025.9

日本

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Authorship：Principal investigator
軽度肥満（内臓脂肪炎症モデル）マウスを用いた歯周炎-NASH連関機構の解明

2022.4 - 2025.6

日本

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Authorship：Coinvestigator(s)
軽度肥満（内臓脂肪炎症モデル）マウスを用いた歯周炎重症化機構の解明

2022.4 - 2025.3

日本

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Authorship：Coinvestigator(s)
インスリン感受性改善薬の局所的投与による糖尿病関連創傷治癒促進法開発のための基盤研究

2022 - 2024

中冨健康科学振興財団研究助成研究助成

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Authorship：Principal investigator Grant type：Contract research
歯周病が糖尿病性腎症における尿細管障害を増悪する分子メカニズムの解明（医学）

2021 - 2022

宇部興産学術振興財団学術奨励賞

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Authorship：Principal investigator Grant type：Contract research
歯周炎による糖尿病性腎臓病増悪における糸球体H-PGDSの役割の解明

2021 - 2022

武田科学振興財団 2021年度医学系研究助成（基礎）

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Authorship：Principal investigator Grant type：Contract research
統合オミクス解析を介した糖尿病関連歯周炎病態の解明 International coauthorship

2020.11 - 2024.3

九州大学大学院歯学研究院歯周病学分野（日本）

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Authorship：Coinvestigator(s)

健常者および2型糖尿病患者の歯肉検体を用いて、マルチオミクス解析による代謝動態の変化を解析し、治療標的として有用な因子を探索する。
歯周炎症-糖尿病性腎症連関メカニズムの解明

2020.4 - 2024.3

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Authorship：Principal investigator
SPOCK1を標的とした革新的歯周病治療薬の開発

2020.4 - 2024.3

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Authorship：Coinvestigator(s)
歯肉幹細胞由来エクソソームmiRNAを標的とした次世代歯周病治療の基盤構築

Grant number：20H03865 2020 - 2023

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
統合オミクス解析を介した糖尿病性歯周炎の病態解明を目指す国際共同研究

Grant number：20KK0212 2020 - 2023

日本学術振興会科学研究費助成事業国際共同研究強化(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
血管内皮細胞におけるインスリン抵抗性が歯周炎増悪に寄与する機序の解明

Grant number：20K18513 2020 - 2022

日本学術振興会科学研究費助成事業若手研究

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Authorship：Principal investigator Grant type：Scientific research funding
歯周炎症-糖尿病性腎臓病連関メカニズムの解明

2020

九州大学ＱＲプログラム（Qdai-jump Research Program）わかばチャレンジ

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Authorship：Principal investigator Grant type：Contract research
歯周病による糖尿病性腎症の病態進行に寄与する腎糸球体内因子の探索

2020

九州大学数理・データサイエンス教育研究センター数理・データサイエンスに関する教育・研究支援プログラム

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Authorship：Principal investigator Grant type：Contract research
歯周病と糖尿病性腎症の関連性についての疫学パイロットスタディ

2020

8020推進財団 8020研究事業(公募研究事業)

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Authorship：Principal investigator Grant type：Contract research
歯周病による糖尿病性腎症の病態進行に寄与する腎糸球体内因子の探索

2020

数理・データサイエンスに関する教育・研究支援プログラム

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
歯周炎症-糖尿病性腎臓病連関メカニズムの解明

2020

九州大学ＱＲプログラム（Qdai-jump Research Program）わかばチャレンジ

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
血管内皮細胞におけるインスリン抵抗性が歯周炎増悪に寄与する役割の検討

2019.4 - 2023.3

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Authorship：Principal investigator
Characterization of Pyruvate Kinase M2 (PKM2) on the progression of diabetic nephropathy

2018 - 2019

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Authorship：Principal investigator Grant type：Contract research
新規DPP4阻害薬anagliptinによるDPP4阻害を介した細菌内毒素(LPS)誘導性炎症反応の抑制効果についての検討

2016 - 2018

金田博夫留学助成

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Authorship：Principal investigator Grant type：Contract research
歯周炎症誘導性Th17細胞免疫応答が脂肪組織における炎症反応に及ぼす影響の検討

2015

九州大学教育研究プログラム・研究拠点形成プロジェクト若手支援

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Authorship：Principal investigator Grant type：Contract research
歯周炎症誘導性Th17細胞免疫応答が脂肪組織における炎症反応に及ぼす影響の検討

2015

平成２７年度九州大学教育研究プログラム・研究拠点形成プロジェクト（Ｐ＆Ｐ）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
SK-0403によるDPP4阻害を媒介した抗炎症作用の分子機序の解明

Grant number：25893149 2013 - 2014

日本学術振興会科学研究費助成事業研究活動スタート支援

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Authorship：Principal investigator Grant type：Scientific research funding

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Educational Activities

・Assistant for clinical preliminary training (for 5th-degree dental students)
・CBT, OSCE
・Assistant for clinical training (for 5th and 6th-degree dental students)
・Assistant for basic clinical training of periodontology (for 4th-degree dental students)

Class subject

歯周病学2

2023.4 - 2023.9 First semester
臨床実習

2023.4 - 2023.9 First semester
歯周病学2実習

2022.4 - 2022.9 First semester
歯学総論7

2021.10 - 2022.3 Second semester
歯周病学実習

2021.4 - 2021.9 First semester
歯科臨床実習

2021.4 - 2021.9 First semester
歯学総論7

2020.10 - 2021.3 Second semester
歯科臨床実習

2020.4 - 2021.3 Full year
歯周病学2

2020.4 - 2020.9 First semester
歯科臨床予備実習

2019.4 - 2020.3 Full year
臨床予備実習

2015.10 - 2016.3 Second semester
統合歯科学特別研究

2015.4 - 2016.3 Full year
歯周病学演習

2015.4 - 2016.3 Full year

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Media Coverage

サンスターラジオ～ちょっと気になる健康のはなし VOL.101～104で回答者として出演 TV or radio program

TBSラジオ 2023.3

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サンスターラジオ～ちょっと気になる健康のはなし VOL.101～104で回答者として出演
サンスターラジオ～ちょっと気になる健康のはなし VOL.62~65で回答者として出演 TV or radio program

TBSラジオ 2022.6

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サンスターラジオ～ちょっと気になる健康のはなし VOL.62~65で回答者として出演
コラム：医局紹介／研究プロジェクトの精鋭たち内にて、「わが医局のエース」として略歴を紹介された。 Newspaper, magazine

2020.4

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コラム：医局紹介／研究プロジェクトの精鋭たち内にて、「わが医局のエース」として略歴を紹介された。

Travel Abroad

2016.5 - 2019.5

Staying countory name 1：United States Staying institution name 1：Section of Vascular Cell Biology, Joslin Diabetes Center

Year of medical license acquisition

2008