HAYASHI CHIKAKO
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
Title
Assistant Professor
Profile
[Research activities]
・The research about the development of periodontal disease treatment using microRNA
・The research of the relationship between endoplasmic reticulum stress and diabetic periodontitis
[Educational activities]
・The Lecture on periodontology for fourth-year dental students
・The guidance on basic clinical training, pre-clinical training, and clinical training guidance for 5th-year dental students
・The guidance for sixth-year dental students during clinical training
[Medical activities]
・Dental treatment with a focus on periodontal disease treatment at Kyushu University
Homepage
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https://www.dent.kyushu-u.ac.jp/perio/index.html
九州大学大学院 歯学研究院
口腔機能修復学講座 歯周病学分野
External link
ORCID
Degree
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Ph.D.（Kyushu University, Japan）
Research Interests・Research Keywords
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Research theme： Development of miRNA therapy for periodontal disease-type 2 diabetes linkage mediated by endoplasmic reticulum stress
Keyword： microRNA, type 2 diabetes, periodontitis
Research period： 2024.4 - 2026.3
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Research theme： Development of a method to control exacerbation of type2 diabetes promoted periodontal disease via endoplasmic reticulum stress
Keyword： Endoplasmic reticulum stress, Type2 diabetes, Periodontitis
Research period： 2023.9 - 2025.3
Awards
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2022年度日本歯周病学会奨励賞
2023.5 日本歯周病学会 歯周病学の発展に寄与する学術論文を発表した若手研究者に対する受賞。
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令和4年度藤野賞
2023.3 九州大学歯学府 大学院博士課程における研究活動（学会発表、論文）に対する表彰
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The 108th Annual Meeting of the American Academy of Periodontology JSP/JACP Excellent Poster Award
2022.11 the American Academy of Periodontology in collaboration with the Japanese Academy of Clinical Periodontology, and the Japanese Society of Periodontology 日本歯周病学会・日本臨床歯周病学会共催アメリカ歯周病学会における優れたポスター発表に対する受賞。
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第８回Young Investigator Award
2022.9 日本歯周病学会 日本歯周病学会で優れた歯周病関連研究をした若手研究者に対する受賞。
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第155回日本歯科保存学会2021年度秋季学術大会カボデンタル優秀ポスター賞
2021.11 日本歯科保存学会 歯科保存治療の再生治療分野での研究発表に対する受賞。
Papers
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miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress Reviewed International journal
Chikako Hayashi, Takao Fukuda, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Yukari Watanabe, Takanori Shinjo, Tomomi Sano, Misaki Iwashita, Karen Yotsumoto, Miyu Shida, Takaharu Taketomi, Terukazu Sanui, Takeshi Uchiumi, Takashi Kanematsu, Fusanori Nishimura
Frontiers in cell and developmental biology 10 2022.11
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Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression Reviewed International journal
Yukari Watanabe, Takao Fukuda, Chikako Hayashi, Yuki Nakao, Masaaki Toyoda, Kentaro Kawakami, Takanori Shinjo, Misaki Iwashita, Hiroaki Yamato, Karen Yotsumoto, Takaharu Taketomi, Takeshi Uchiumi, Terukazu Sanui, Fusanori Nishimura
Scientific reports 2022.8
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Scaffold-free bone-like 3D structure established through osteogenic differentiation from human gingiva-derived stem cells Reviewed International journal
Masaaki Toyoda, Takao Fukuda, Ryota Fujimoto, Kentaro Kawakami, Chikako Hayashi, Yuki Nakao, Yukari Watanabe, Tsukasa Aoki, Miyu Shida, Terukazu Sanui, Masahide Taguchi, Kensuke Yamamichi, Ayami Okabe, Tatsunori Okada Kyoko Oka, Koichi Nakayama , Fusanori Nishimura, Shunichi Kajioka
Biochemistry and biophysics reports 2024.2
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Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation Reviewed International journal
Kentaro Kawakami, Takao Fukuda, Masaaki Toyoda, Yuki Nakao, Chikako Hayashi, Yukari Watanabe, Tsukasa Aoki, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Miyu Shida, Terukazu Sanui, Takeshi Uchiumi, Fusanori Nishimura
BioMed research international 2024.1
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Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells Reviewed International journal
Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Ryosuke Aihara, Misaki Iwashita, Urara Tanaka, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura
Journal of cellular biochemistry 122 ( 7 ) 716 - 730 2021.7
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Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss Reviewed International journal
Yuki Nakao, Takao Fukuda, Qunzhou Zhang, Terukazu Sanui, Takanori Shinjo, Xiaoxing Kou, Chider Chen, Dawei Liu, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Anh D Le, Songtao Shi, Fusanori Nishimura
Acta biomaterialia ( 122 ) 306 - 324 2021.3
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Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages Reviewed International journal
Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura
Frontiers in immunology 11 709 2020.4
Presentations
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miR-1260b promotes M2 macrophage polarization by targeting NFAT5 and NLRP3 International conference
Chikako Hayashi, Masaaki Toyoda, Kentaro Kawakami, Yuki Nakao, Miyu Shida, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura
IADR/AADOCR/CADR General Session & Exhibition 2024 2024.3
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miR-1260b inhibits periodontal bone loss by targeting ATF6β International conference
Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Yukari Watanabe, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura
The 108th Annual Meeting of the American Academy of Periodontology 2022.10
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Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress International conference
Chikako Hayashi, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura
The 69th Annual Meeting of Japanese Association for Dental Research 2021.10
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Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress International conference
Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura
Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium 2021.11
Professional Memberships
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JAPANESE SOCIETY OF PERIODONTOLOGY
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The Japanese Society of Conservative Dentistry
Research Projects
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小胞体ストレスを介した歯周病-２型糖尿病連関に対するmiRNA治療法の開発
2024.4 - 2026.3
Authorship：Principal investigator
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小胞体ストレスを介した歯周病-２型糖尿病連関に対するmiRNA治療法の開発
Grant number：24K19899 2024 - 2025
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists
Authorship：Principal investigator Grant type：Scientific research funding
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小胞体ストレスを介した2型糖尿病による歯周病の増悪制御法の開発 研究課題
2023.8 - 2025.3
Authorship：Principal investigator
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小胞体ストレスを介した2型糖尿病による歯周病の増悪制御法の開発
Grant number：23K19722 2023 - 2024
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up
Authorship：Principal investigator Grant type：Scientific research funding
Educational Activities
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【九州大学歯学部】
４年生：歯周病学１の講義
５年生：臨床予備実習および臨床実習における指導
６年生：臨床実習における指導
Class subject
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歯周病学2
2024.4 - 2024.9 First semester
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歯科臨床実習
2024.4 - 2024.9 First semester
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歯周病学1
2023.10 - 2024.3 Second semester
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歯科臨床実習
2023.10 - 2024.3 Second semester
FD Participation
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2024.4 Role：Participation Title：令和６年度 第１回全学FD（新任教員の研修）The 1st All-University FD (training for new faculty members) in FY2024
Organizer：University-wide
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2023.8 Role：Participation Title：令和５年度４部局合同男女共同参画ＦＤ
Organizer：University-wide
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Dentistry / Periodontal Dentistry
Year of medical license acquisition
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2018