Updated on 2024/07/28

Information

 

写真a

 
KANEKO NAOKI
 
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
Abolition organization Maxill Ofacial Surgery(Joint Appointment)
School of Dentistry Department of Dentistry(Joint Appointment)
Graduate School of Dental Science (Joint Appointment)
Graduate School of Dental Science Department of Dental Science(Joint Appointment)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426447
Profile
臨床:口腔外科全般 研究:日米国際共同研究によるCOVID-19、IgG4関連疾患、シェーグレン症候群、強皮症および線維性縦隔炎の病態形成メカニズムの解明と新規治療法開発。口腔扁平上皮癌におけるKLKを介した転移機構の解明。 研究:大学院生の研究指導、歯学部学生の臨床実習指導、研修医の臨床指導
External link

Degree

  • D.D.S

Research Interests・Research Keywords

  • Research theme:The disease-specific T cell and B cell in the pathogenesis of Sjogren syndrome

    Keyword:Sjogren syndrome

    Research period: 2022.1 - 2025.3

  • Research theme:Investigation of the specific immune mechanism in COVID-19

    Keyword:COVID-19

    Research period: 2020.4 - 2022.4

  • Research theme:The expansion of cytotoxic T lymphocytes in IgG4-RD

    Keyword:IgG4-RD

    Research period: 2018.4 - 2022.4

Awards

  • IADR Unilever Hatton Divisional Award

    2017.5   The International Association for Dental Research (IADR),  

  • 九州大学学生後援会 学術研究賞受賞

    2017.5   九州大学学生後援会  

  • 藤野博賞受賞

    2017.3   九州大学歯学府  

  • 九州大学学生表彰受賞

    2017.3   九州大学  

  • 第35回日本口腔腫瘍学会総会・学術大会 優秀ポスター賞受賞

    2017.1   日本口腔腫瘍学会  

  • 第70回日本口腔科学会学術集会 学会賞若手優秀ポスター賞

    2016.3   日本口腔科学会  

  • 95th General Session & Exhibition of the IADR Hatton Award Finalist of JADR

    2016.3   Japanese Association for Dental Research (JADR)  

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Papers

  • Orchestration of Immune Cells Contributes to Fibrosis in IgG4-Related Disease Invited Reviewed International journal

    Naoki Kaneko, Masafumi Moriyama, Takashi Maehara, Hu Chen, Yuka Miyahara and Seiji Nakamura

    Immuno   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome Reviewed International journal

    2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-19397-w

  • Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19 Reviewed International journal

    medRxib   2021.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 Reviewed International journal

    Cell   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma Reviewed International journal

    Naoki Kaneko, Shintaro Kawano*, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Tamotsu Kiyoshima, Seiji Nakamura

    2017.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Unilateral scissors bite treated by posterior segmental maxillary osteotomy and corticotomy-assisted mandibular expansion

    Ryoji Kitamura, Masafumi Moriyama, Hiroe Kakehashi, Kenichi Ogata, Naoki Kaneko, Taiki Sakamoto, Ichiro Takahashi, Shintaro Kawano

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2024.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajoms.2024.01.006

  • Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K. International journal

    Yuka Miyahara, Hu Chen, Masafumi Moriyama, Keita Mochizuki, Naoki Kaneko, A S M Rafiul Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, Masaki Yamauchi, Kenichi Ogata, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura

    Scientific reports   13 ( 1 )   19320 - 19320   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-46090-3

  • Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

    42 ( 6 )   112630 - 112630   2023.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112630

  • Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19 Reviewed International journal

    2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112630

  • Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome. International journal

    12 ( 1 )   15427 - 15427   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Sjögren's syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren's syndrome were undertaken, including the quantitation of the frequency of selected cell-cell interactions in the disease milieu. Quantitative analyses of CD4+ T cell subsets and of CD8+ T cells in the labial salivary glands from untreated patients with primary Sjögren's syndrome revealed that activated CD8+ cytotoxic T cells (CD8+CTLs) were the most prominent T cells in these infiltrates. An accumulation of apoptotic glandular epithelial cells, mainly ductal and acinar cells, was observed, consistent with the impaired salivary secretion often observed in patients with this disease. FasL expressing activated CD8+ T cells were seen to accumulate around Fas expressing apoptotic epithelial cells. Quantitative analyses of apoptotic cell types and of conjugates between cytotoxic T cells and epithelial cells undergoing apoptosis suggest that Sjögren's syndrome is primarily driven by CD8+CTL mediated execution of epithelial cells mainly represented by ductal and acinar cells.

    DOI: 10.1038/s41598-022-19397-w

  • Comparison of computed tomography findings between odontogenic keratocyst and ameloblastoma in the mandible: Criteria for differential diagnosis Invited Reviewed International journal

    Naoki Kaneko, Junsei Sameshima, Shintaro Kawano, Toru Chikui, Takeshi Mitsuyasu, Hu Chen, Taiki Sakamoto, Seiji Nakamura

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2022.8

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  • Distinct disease-specific Tfh cell populations in two different fibrotic diseases: IgG4-related disease and Kimura's disease. International journal

    Ryusuke Munemura, Takashi Maehara, Yuka Murakami, Risako Koga, Ryuichi Aoyagi, Naoki Kaneko, Atsushi Doi, Cory A Perugino, Emanuel Della-Torre, Takako Saeki, Yasuharu Sato, Hidetaka Yamamoto, Tamotsu Kiyoshima, John H Stone, Shiv Pillai, Seiji Nakamura

    The Journal of allergy and clinical immunology   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2022.03.034

  • Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19. International journal

    Naoki Kaneko, Julie Boucau, Hsiao-Hsuan Kuo, Cory Perugino, Vinay S Mahajan, Jocelyn R Farmer, Hang Liu, Thomas J Diefenbach, Alicja Piechocka-Trocha, Kristina Lefteri, Michael T Waring, Katherine R Premo, Bruce D Walker, Jonathan Z Li, Gaurav Gaiha, Xu G Yu, Mathias Lichterfeld, Robert F Padera Jr, Shiv Pillai

    Clinical immunology (Orlando, Fla.)   237   108991 - 108991   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.clim.2022.108991

  • Orchestration of Immune Cells Contributes to Fibrosis in IgG4-Related Disease

    Naoki Kaneko, Masafumi Moriyama, Takashi Maehara, Hu Chen, Yuka Miyahara, Seiji Nakamura

    Immuno   2 ( 1 )   170 - 184   2022.2

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    DOI: 10.3390/immuno2010013

  • ΔNp63を介した口腔扁平上皮癌の上皮間葉転換におけるprotease-activated receptor 1の関与

    服部 多市, 川野 真太郎, 田中 翔一, 金子 直樹, 坂本 泰基, 丸瀬 靖之, 濱田 栄樹, 樋渡 萌美, 白石 由梨香, 中村 誠司

    日本口腔科学会雑誌   70 ( 2 )   113 - 113   2021.7

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  • CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease Reviewed International journal

    Cory A. Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Emanuel Della-Torre, Samuel JH. Murphy, Musie Ghebremichael, Zachary S. Wallace, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B. Montesi, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef,John H. Stone, Shiv Pillai

    J Allergy Clin Immunol   2021.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19. International journal

    Naoki Kaneko, Julie Boucau, Hsiao-Hsuan Kuo, Cory Perugino, Vinay S Mahajan, Jocelyn R Farmer, Hang Liu, Thomas J Diefenbach, Alicja Piechocka-Trocha, Kristina Lefteri, Michael T Waring, Katherine R Premo, Bruce D Walker, Jonathan Z Li, Gaurav Gaiha, Xu G Yu, Mathias Lichterfeld, Robert F Padera, Shiv Pillai

    medRxiv : the preprint server for health sciences   2021.3

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    Language:English  

    DOI: 10.1101/2021.03.23.21253885

  • Treating life-threatening TAFRO syndrome with interleukin-1 inhibition. International journal

    Marco Lanzillotta, Miriam Sant'Angelo, Naoki Kaneko, Shiv Pillai, Maurilio Ponzoni, Emanuel Della-Torre

    European journal of internal medicine   87   121 - 123   2021.2

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    DOI: 10.1016/j.ejim.2021.02.006

  • Treating life-threatening TAFRO syndrome with interleukin-1 inhibition Reviewed International journal

    Marco Lanzillotta, Miriam Sant'Angelo, Naoki Kaneko, Shiv Pillai, Maurilio Ponzoni , Emanuel Della-Torre

    Eur J Intern Med   2021.2

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  • CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. International journal

    Hugues Allard-Chamard, Faisal Alsufyani, Naoki Kaneko, Kelly Xing, Cory Perugino, Vinay S Mahajan, Joseph L Wheat, George S Deepe Jr, James Loyd, Shiv Pillai

    Journal of immunology (Baltimore, Md. : 1950)   206 ( 3 )   524 - 530   2021.2

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    DOI: 10.4049/jimmunol.2000433

  • Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease. International journal

    Lucrezia Rovati, Naoki Kaneko, Federica Pedica, Antonella Monno, Takashi Maehara, Cory Perugino, Marco Lanzillotta, Simone Pecetta, John H Stone, Claudio Doglioni, Angelo A Manfredi, Shiv Pillai, Emanuel Della-Torre

    Rheumatology (Oxford, England)   60 ( 10 )   4929 - 4941   2021.1

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    DOI: 10.1093/rheumatology/keab096

  • Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease Reviewed International journal

    2021.1

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  • CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease. International journal

    Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai

    The Journal of allergy and clinical immunology   147 ( 1 )   368 - 382   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2020.05.022

  • CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. Invited Reviewed International journal

    Hugues Allard-Chamard, Faisal Alsufyani, Naoki Kaneko, Kelly Xing, Cory Perugino, Vinay S. Mahajan, Joseph L. Wheat, George S. Deepe Jr., James Loyd and Shiv Pillai

    The Journal of Immunology   2020.12

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  • Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. International journal

    Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R Farmer, Hugues Allard-Chamard, Vinay S Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matthew Osborn, Julia Bals, Yannic C Bartsch, Nathalie Bonheur, Timothy M Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L Ly, Ashlin R Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J Ticheli, Michael T Waring, Alex L Zhu, Galit Alter, Jonathan Z Li, Daniel Lingwood, Aaron G Schmidt, Mathias Lichterfeld, Bruce D Walker, Xu G Yu, Robert F Padera Jr, Shiv Pillai

    Cell   183 ( 1 )   143 - 157   2020.10

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    DOI: 10.1016/j.cell.2020.08.025

  • B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma Invited Reviewed International journal

    Claudia Minici, Elena Rigamonti, Marco Lanzillotta, Antonella Monno, Lucrezia Rovati, Takashi Maehara, Naoki Kaneko, Vikram Deshpande, Maria Pia Protti, Lucia De Monte, Cristina Scielzo, Stefano Crippa, Paolo Giorgio Arcidiacono, Erica Dugnani, Lorenzo Piemonti, Massimo Falconi, Shiv Pillai, Angelo A. Manfredi, and Emanuel Della-Torre

    Oncoimmunology   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19. International journal

    Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R Farmer, Hugues Allard-Chamard, Vinay S Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matt Osborn, Julia Bals, Yannic C Bartsch, Nathalie Bonheur, Timothy M Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L Ly, Ashlin R Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J Ticheli, Michael T Waring, Alex L Zhu, Jonathan Li, Daniel Lingwood, Aaron G Schmidt, Matthias Lichterfeld, Bruce D Walker, Xu Yu, Robert F Padera Jr, Shiv Pillai

    SSRN   3652322 - 3652322   2020.7

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    DOI: 10.2139/ssrn.3652322

  • B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma. International journal

    Claudia Minici, Elena Rigamonti, Marco Lanzillotta, Antonella Monno, Lucrezia Rovati, Takashi Maehara, Naoki Kaneko, Vikram Deshpande, Maria Pia Protti, Lucia De Monte, Cristina Scielzo, Stefano Crippa, Paolo Giorgio Arcidiacono, Erica Dugnani, Lorenzo Piemonti, Massimo Falconi, Shiv Pillai, Angelo A Manfredi, Emanuel Della-Torre

    Oncoimmunology   9 ( 1 )   1794359 - 1794359   2020.7

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    DOI: 10.1080/2162402X.2020.1794359

  • Elevated expression of protease-activated receptor 1 via ΔNp63 down-regulation contributes to nodal metastasis in oral squamous cell carcinoma Reviewed International journal

    T. Hattori, S. Kawano*, S. Tanaka, R. Matsubara, T. Sakamoto, Y. Hashiguchi, N. Kaneko, Y. Mikami, M. Morioka, Y. Maruse, R. Kitamura, E. Hamada, M. Hiwatashi, K. Oobu, T. Kiyoshima, S. Nakamura

    2020.6

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  • Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. International journal

    Takashi Maehara, Naoki Kaneko, Cory A Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Samuel Jh Murphy, Musie Ghebremichael, David Fox, Aimee S Payne, Robert Lafyatis, John H Stone, Dinesh Khanna, Shiv Pillai

    The Journal of clinical investigation   130 ( 5 )   2451 - 2464   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/JCI131700

  • Immune mechanisms of fibrosis and inflammation in IgG4-related disease. International journal

    Shiv Pillai, Cory Perugino, Naoki Kaneko

    Current opinion in rheumatology   32 ( 2 )   146 - 151   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BOR.0000000000000686

  • Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis Reviewed International journal

    Takashi Maehara, Naoki Kaneko, Cory A Perugino, Hamid Mattoo1,4, Jesper Kers1,5,6, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Samuel JH Murphy, Musie Ghebremichael, David Fox, Aimee S. Payne, Robert Lafyatis, John H. Stone, Dinesh Khanna, Shiv Pillai

    Journal of Clinical Investigation   2020.3

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  • B lymphocytes directly contribute to tissue fibrosis in IgG4-Related Disease Reviewed International journal

    Journal of Clinical Investigation.   2020.3

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  • Immune mechanisms of fibrosis and inflammation in IgG4-related disease Reviewed International journal

    Shiv Pillai, Cory A Perugino, Naoki Kaneko

    Curr Opin Rheumatol   2020.3

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  • B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. International journal

    Emanuel Della-Torre, Elena Rigamonti, Cory Perugino, Simona Baghai-Sain, Na Sun, Naoki Kaneko, Takashi Maehara, Lucrezia Rovati, Maurilio Ponzoni, Raffaella Milani, Marco Lanzillotta, Vinay Mahajan, Hamid Mattoo, Ivan Molineris, Vikram Deshpande, John H Stone, Massimo Falconi, Angelo A Manfredi, Shiv Pillai

    The Journal of allergy and clinical immunology   145 ( 3 )   968 - 981   2020.3

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    DOI: 10.1016/j.jaci.2019.07.004

  • ΔNp63を介した口腔扁平上皮癌の上皮間葉転換におけるprotease-activated receptor 1の関与

    服部 多市, 川野 真太郎, 田中 翔一, 金子 直樹, 坂本 泰基, 橋口 有真, 大部 一成, 中村 誠司

    日本口腔診断学会雑誌   33 ( 1 )   113 - 114   2020.2

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  • cytokeratin 19の発現亢進が口腔扁平上皮癌の浸潤・遊走能に与える影響 ΔNp63との関わりについて

    田中 翔一, 川野 真太郎, 服部 多市, 坂本 泰基, 金子 直樹, 橋口 有真, 大部 一成, 中村 誠司

    日本口腔診断学会雑誌   33 ( 1 )   114 - 114   2020.2

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  • Cytokeratin 19 as a biomarker of highly invasive oral squamous cell carcinoma with metastatic potential

    Shoichi Tanaka, Shintaro Kawano, Taichi Hattori, Ryota Matsubara, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Yurie Mikami, Masahiko Morioka, Yasuyuki Maruse, Ryoji Kitamura, Eiki Hamada, Megumi Hiwatashi, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   32 ( 1 )   1 - 7   2020.1

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    DOI: 10.1016/j.ajoms.2019.10.007

  • Cytokeratin 19 as a biomarker of highly invasive oral squamous cell carcinoma with metastatic potential Invited Reviewed International journal

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2020.1

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  • ΔNp63を介した口腔扁平上皮癌の上皮間葉転換におけるprotease-activated receptor 1の関与

    服部 多市, 川野 真太郎, 田中 翔一, 金子 直樹, 坂本 泰基, 橋口 有真, 大部 一成, 中村 誠司

    日本口腔内科学会雑誌   25 ( 2 )   103 - 104   2019.12

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  • Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease Reviewed International journal

    Maehara Takashi, Munemura Ryusuke, Shimizu Mayumi, Kakizoe Noriko, Kaneko Naoki, Murakami Yuka, Masafumi Moriyama, Kiyoshima Tamotsu, Kawano Shintaro, Nakamura Seiji

    Medicine,   2019.12

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  • Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report. International journal

    Takashi Maehara, Ryusuke Munemura, Mayumi Shimizu, Noriko Kakizoe, Naoki Kaneko, Yuka Murakami, Moriyama Masafumi, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura

    Medicine   98 ( 50 )   e18300   2019.12

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    DOI: 10.1097/MD.0000000000018300

  • cytokeratin 19の発現亢進が口腔扁平上皮癌の浸潤・遊走能に与える影響 ΔNp63との関わりについて

    田中 翔一, 川野 真太郎, 服部 多市, 坂本 泰基, 金子 直樹, 橋口 有真, 大部 一成, 中村 誠司

    日本口腔内科学会雑誌   25 ( 2 )   104 - 104   2019.12

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  • CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production. International journal

    A S M Rafiul Haque, Masafumi Moriyama, Keigo Kubota, Noriko Ishiguro, Mizuki Sakamoto, Akira Chinju, Keita Mochizuki, Taiki Sakamoto, Naoki Kaneko, Ryusuke Munemura, Takashi Maehara, Akihiko Tanaka, Jun-Nosuke Hayashida, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura

    Scientific reports   9 ( 1 )   14611 - 14611   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-51149-1

  • CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production Reviewed International journal

    Scientific Reports   2019.9

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  • 次世代シークエンサー解析が紐解く、全身性強皮症の病態におけるClonalに増殖したCD4+T細胞 国際共同研究

    前原 隆, Perugino Cory, 金子 直樹, Mattoo Hamid, 宗村 龍祐, 山元 英崇, Pillai Shiv, 中村 誠司

    日本口腔科学会雑誌   68 ( 2 )   174 - 174   2019.7

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  • 口腔扁平上皮癌におけるΔNp63を介したkallikrein-related peptidase(KLK)5の発現と機能について

    服部 多市, 川野 真太郎, 松原 良太, 坂本 泰基, 橋口 有真, 金子 直樹, 田中 翔一, 大部 一成, 中村 誠司

    日本口腔科学会雑誌   68 ( 2 )   143 - 144   2019.7

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  • Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2. International journal

    233 ( 10 )   6565 - 6577   2018.10

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    We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs responsible for ΔNp63β-mediated EMT, miRNA microarray analyses were performed by ΔNp63β-overexpression in OSCC cells; SQUU-B, which lacks ΔNp63 expression and displays EMT phenotypes. miRNAs microarray analyses revealed miR-205 was the most up-regulated following ΔNp63β-overexpression. In OSCC cells, miR-205 expression was positively associated with ΔNp63 and negatively with zinc-finger E-box binding homeobox (ZEB) 1 and ZEB2, potential targets of miR-205. miR-205 overexpression by miR-205 mimic transfection into SQUU-B cells led to decreasing ZEB1, ZEB2, and mesenchymal markers, increasing epithelial markers, and reducing cell motilities, suggesting inhibition of EMT phenotype. Interestingly, the results opposite to this phenomenon were obtained by transfection of miR-205 inhibitor into OSCC cells, which express ΔNp63 and miR-205. Furthermore, target protector analyses revealed direct regulation by miR-205 of ZEB1 and ZEB2 expression. These results showed tumor-suppressive roles of ΔNp63β and miR-205 by inhibiting EMT thorough modulating ZEB1 and ZEB2 expression in OSCC.

    DOI: 10.1002/jcp.26267

  • 舌エコーの画像所見による潜在的頸部リンパ節転移の予測

    服部 多市, 川野 真太郎, 三上 友里恵, 筑井 徹, 河津 俊幸, 松原 良太, 後藤 雄一, 金子 直樹, 坂本 泰基, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司

    日本口腔科学会雑誌   67 ( 2 )   200 - 201   2018.7

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  • Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and poor prognosis in oral squamous cell carcinoma Reviewed International journal

    International Journal of Oral and Maxillofacial Surgery   2018.7

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  • CD206+腫瘍関連マクロファージは癌細胞増殖を促進する(CD206+ tumor-associated macrophages promote cancer cell proliferation)

    Haque Rafiul A.S.M., 森山 雅文, 久保田 恵吾, 石黒 乃理子, 坂本 瑞樹, 鎮守 晃, 望月 敬太, 坂本 泰基, 金子 直樹, 宗村 龍祐, 田中 昭彦, 前原 隆, 林田 淳之將, 川野 真太郎, 中村 誠司

    日本口腔科学会雑誌   67 ( 2 )   103 - 103   2018.7

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  • Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma Reviewed

    Y. Maruse, S. Kawano, T. Jinno, R. Matsubara, Y. Goto, N. Kaneko, T. Sakamoto, Y. Hashiguchi, M. Moriyama, T. Toyoshima, R. Kitamura, H. Tanaka, K. Oobu, T. Kiyoshima, S. Nakamura

    International Journal of Oral and Maxillofacial Surgery   47 ( 7 )   836 - 845   2018.7

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    DOI: 10.1016/j.ijom.2018.01.004

  • Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma. International journal

    75   148 - 157   2017.12

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    We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells. By ΔNp63 knockdown, KLK6 and PAR2 expression was decreased and PAR1 was increased. Furthermore, KLK6 knockdown led to enhancing migration and invasion, and inhibiting proliferation, suggesting EMT-phenotypes. Although, in the KLK6 or PAR2 knockdown cells, phosphorylation of ERK was reduced, it was restored in the KLK6 knockdown OSCC cells treated with recombinant KLK6 proteins. Immunohistochemistry showed ΔNp63, KLK6, and PAR2 were more strongly expressed in the epithelial dysplasia and central region of OSCC than normal oral epithelium, whereas PAR1 expression was undetectable. Interestingly, at the invasive front of OSCC, ΔNp63, KLK6, and PAR2 were reduced, but PAR1 was elevated. In addition, the OSCC patients with decreasing KLK6 expression at the invasive front had more unfavourable prognosis. These results suggested differential roles of KLK6 in malignant transformation and EMT; high ΔNp63β expression up-regulates KLK6-PAR2 and down-regulates PAR1, inducing malignant transformation in oral epithelium with stimulating proliferation through ERK signal activation. Moreover, KLK6-PAR2 expression is down-regulated and PAR1 is up-regulated when ΔNp63β expression is decreased, leading to EMT with enhancing migration and invasion through ERK signal reduction at the invasive front.

    DOI: 10.1016/j.oraloncology.2017.11.004

  • Tumor-suppressive roles of ΔNp63-miR205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2 Reviewed International journal

    Yuma Hashiguchi, Shintaro Kawano*, Yuichi Goto, Yasuda Kaori, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Tamotsu Kiyoshima, Seiji Nakamura

    2017.10

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  • 小唾液腺癌45例の臨床病理学的検討

    服部 多市, 松原 良太, 坂本 泰基, 川野 真太郎, 金子 直樹, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司

    日本口腔科学会雑誌   66 ( 2 )   111 - 111   2017.7

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  • Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. International journal

    69   15 - 25   2017.6

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    OBJECTIVES: We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype. MATERIALS AND METHODS: Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2. RESULTS: Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis. CONCLUSION: Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following ΔNp63β-mediated EMT.

    DOI: 10.1016/j.oraloncology.2017.03.019

  • Critical roles of Wnt5a-Ror2 signaling in aggressiveness of oral squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition Reviewed International journal

    Taiki Sakamoto, Shintaro Kawano*, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Tamotsu Kiyoshima, Seiji Nakamura

    2017.6

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  • 口腔扁平上皮癌におけるmiR-205の発現と機能 ΔNp63との関連について

    橋口 有真, 川野 真太郎, 後藤 雄一, 松原 良太, 金子 直樹, 坂本 泰基, 神野 哲平, 丸瀬 靖之, 田中 秀明, 服部 多市, 田中 翔一, 中村 誠司

    頭頸部癌   43 ( 2 )   290 - 290   2017.5

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  • 舌下腺に生じた多形腺腫の1例と文献的考察

    金子 直樹, 松原 良太, 川野 真太郎, 見立 英史, 神野 哲平, 丸瀬 靖之, 坂本 泰基, 橋口 有真, 清島 保, 中村 誠司

    日本口腔内科学会雑誌   22 ( 2 )   79 - 83   2016.12

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    多形腺腫は最も高頻度の唾液腺腫瘍であるが、舌下腺に生じるのはまれである。また舌下腺腫瘍の多くは悪性であるため、診断に苦慮することも多い。われわれは舌下腺多形腺腫の1例を経験したので、文献的考察を加え報告する。症例は60歳代男性で、左側口底部の腫瘤を主訴に来院、外科的切除を行い、多形腺腫の診断を得た。術後1年6ヵ月経過した現在、再発は認めていない。舌下腺腫瘍を疑う際は、悪性に準じた対応が重要である。(著者抄録)

  • Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor: a case report and literature review. Reviewed International journal

    World J Surg Oncol   2016.10

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  • 陰圧閉鎖療法により治療した頸部郭清術後リンパ漏の2例

    見立 英史, 川野 真太郎, 松原 良太, 橋口 有真, 金子 直樹, 坂本 泰基, 中村 誠司

    日本口腔腫瘍学会誌   28 ( 3 )   155 - 160   2016.9

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    今回われわれは、頸部郭清術後にリンパ漏を認め、陰圧閉鎖療法(NPWT)を行って治癒し得た2症例を経験したので報告する。【症例1】71歳、男性。左側頬粘膜扁平上皮癌(T2N2bM0)に対し、術前放射線化学療法後、根治的頸部郭清術(RND)、上顎部分切除術、頬粘膜部分切除術、下顎区域切除術、前外側大腿皮弁とチタンプレートによる再建術を施行。術後より、鎖骨上窩にリンパ液貯留を認めていた。術後12日目、左側頸部の出血を認めたため、止血処置およびリンパ漏出部位の結紮を行った。しかし、術後もリンパ液貯留が継続したため、再手術から3日後にNPWTを開始した。開始1週間でリンパ漏は消退した。【症例2】64歳、男性。左側舌扁平上皮癌術後に頸部リンパ節後発転移を認め、RNDを施行。術後15日目に鎖骨上窩にリンパ液貯留を認め、症例1と同様にNPWTを開始した。徐々にリンパ漏は消失し、NPWTは26日間で終了した。NPWTは頸部郭清術後リンパ漏に対し、有用な治療法の1つになり得ると考えられた。(著者抄録)

  • 口腔扁平上皮癌におけるmiR-205の発現と機能に関する研究 特にΔNp63との関連について

    橋口 有真, 川野 真太郎, 後藤 雄一, 松原 良太, 神野 哲平, 丸瀬 靖之, 金子 直樹, 坂本 泰基, 松村 万由, 中村 誠司

    日本口腔科学会雑誌   65 ( 2 )   180 - 180   2016.7

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  • Erratum to: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review. International journal

    Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura

    World journal of surgical oncology   14 ( 1 )   187 - 187   2016.7

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  • Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review. International journal

    Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura

    World journal of surgical oncology   14 ( 1 )   161 - 161   2016.6

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    DOI: 10.1186/s12957-016-0918-1

  • 舌下腺に生じた多形腺腫の1例と文献的考察 Invited Reviewed International journal

    金子直樹, 松原良太*, 川野真太郎, 見立英史, 神野哲平, 丸瀬靖之, 坂本泰基, 橋口有真, 清島 保, 中村誠司

    日本口腔内科学会雑誌   2016.5

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  • 陰圧閉鎖療法により治療した頸部郭清術後リンパ漏の2例 Invited Reviewed International journal

    見立英史, 川野真太郎*, 松原良太, 田中昭彦, 金子直樹, 橋口有真, 坂本泰基, 中村誠司

    日本口腔腫瘍学会雑誌   2016.4

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  • 舌粘膜疹と皮疹を認めた第2期梅毒の1例

    金子 直樹, 川野 真太郎, 松原 良太, 笹栗 正明, 森山 雅文, 丸瀬 靖之, 三上 友里恵, 清島 保, 中村 誠司

    日本口腔内科学会雑誌   21 ( 2 )   38 - 42   2015.12

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    今回、舌粘膜疹を主訴に来院した第2期梅毒の1例を経験した。症例は20歳代の女性で、舌尖および舌縁部の白色病変と両手掌の丘疹性紅斑を認めた。梅毒血清検査にて陽性であったため第2期梅毒と診断し、抗菌薬内服を開始した。その後、口腔粘膜疹および皮疹は消退し、梅毒血清検査は陰性化した。近年、本症例のように口腔粘膜疹が梅毒の初発症状となる症例が増えており、今後注意を要すると考えられた。(著者抄録)

  • 口腔扁平上皮癌の浸潤・転移におけるΔNp63発現抑制が導く上皮間葉転換の関与

    後藤 雄一, 川野 真太郎, 松原 良太, 橋口 有真, 坂本 泰基, 金子 直樹, 丸瀬 靖之, 神野 哲平, 中村 康大, 浜田 倫史, 大部 一成, 杉浦 剛, 中村 誠司

    日本癌学会総会記事   74回   P - 3011   2015.10

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  • 唾液腺悪性腫瘍の臨床病理学的検討

    坂本 泰基, 後藤 雄一, 川野 真太郎, 松原 良太, 神野 哲平, 丸瀬 靖之, 金子 直樹, 橋口 有真, 森岡 政彦, 大部 一成, 中村 誠司

    頭頸部癌   41 ( 2 )   195 - 195   2015.5

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  • 舌粘膜疹と皮疹を認めた第2期梅毒の1例 Reviewed International journal

    金子直樹, 川野真太郎*, 松原良太, 笹栗正明, 森山雅文, 丸瀬靖之, 清島 保, 中村誠司

    日本口腔内科学会雑誌   2015.5

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  • Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma. International journal

    Teppei Jinno, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Takeshi Toyoshima, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

    Oncology reports   33 ( 5 )   2161 - 8   2015.5

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    DOI: 10.3892/or.2015.3838

  • 口腔扁平上皮癌におけるIL-6の発現と機能 抗癌剤抵抗性との関連について

    神野 哲平, 川野 真太郎, 松原 良太, 後藤 雄一, 丸瀬 靖之, 坂本 泰基, 橋口 有真, 金子 直樹, 神野 彰子, 森岡 政彦, 大部 一成, 清島 保, 中村 誠司

    頭頸部癌   41 ( 2 )   242 - 242   2015.5

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  • 口腔癌手術後に経口にて栄養摂取できなかった症例についての検討

    後藤 雄一, 大部 一成, 星野 亜紀, 金子 直樹, 今利 一寿, 三上 友理恵, 森 悦秀, 中村 誠司

    日本摂食・嚥下リハビリテーション学会雑誌   18 ( 3 )   S67 - S67   2014.12

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  • 著明な石灰化と骨形成を伴った舌下腺粘表皮癌の1例

    丸瀬 靖之, 川野 真太郎, 清島 保, 後藤 雄一, 吉賀 大午, 松原 良太, 神野 哲平, 金子 直樹, 坂本 泰基, 橋口 有真, 中村 誠司

    日本口腔科学会雑誌   63 ( 4 )   438 - 438   2014.9

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  • 口腔扁平上皮癌におけるIL-6の発現と機能 抗癌剤抵抗性獲得への関与について

    神野 哲平, 川野 真太郎, 松原 良太, 後藤 雄一, 清島 保, 丸瀬 靖之, 神野 彰子, 金子 直樹, 坂本 泰基, 橋口 有真, 森山 雅文, 大部 一成, 杉浦 剛, 中村 誠司

    日本口腔科学会雑誌   63 ( 4 )   424 - 424   2014.9

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  • Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma Reviewed International journal

    Oncol Rep   2014.5

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Books

  • 新型コロナウイルス感染における免疫記憶の異常:二次リンパ器官の所見からの考察.

    金子直樹*, Shiv Pillai.( Role: Joint author)

    実験医学 羊土社  2021.3 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 新型コロナウイルス感染症における液性免疫の異常―胚中心およびBcl6陽性濾胞性ヘルパーT細胞の減少.

    金子直樹、Shiv Pillai( Role: Joint author)

    医学のあゆみ  2021.10 

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MISC

  • 全身性強皮症における疾患特異的T細胞の発見と新規治療法への検討

    前原 隆, 金子 直樹, Perugino Cory, 宗村 龍祐, 村上 祐香, 中村 誠司

    日本臨床免疫学会総会プログラム・抄録集   2020.10

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  • IgG4関連疾患の病態形成におけるClonalに増殖したCD4+CTLとCD8+CTL細胞の病態への関与

    前原 隆, 金子 直樹, 宗村 龍祐, 村上 祐香, 中村 誠司

    日本口腔科学会雑誌   2020.7

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  • 次世代シークエンス解析による木村氏病の病態解明 Th2型サイトカインを産生するIgE+c-kit+マスト細胞と特異なT細胞の関与

    宗村 龍祐, 前原 隆, 金子 直樹, 村上 祐香, 柿添 乃理子, 坂本 瑞樹, 望月 敬太, 森山 雅文, 川野 真太郎, 中村 誠司

    日本口腔科学会雑誌   2020.7

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Professional Memberships

  • 日本口腔外科学会

  • 日本口腔科学会

  • 日本口腔内科学会

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

Research Projects

  • 疾患特異的環境下における自己抗体産生B 細胞とその抗原の同定

    Grant number:23K18362  2023 - 2025

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 疾患特異的環境下における自己抗体産生B 細胞とその抗原の同定

    Grant number:23K18362  2023 - 2025

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 口腔扁平上皮癌の浸潤転移における細胞障害性T細胞およびB細胞の関連

    2022.1 - 2028.3

    日本 

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    Authorship:Principal investigator 

  • シェーグレン症候群の病態を形成する免疫ネットワークの解明

    2022.1 - 2027.3

    日本 

  • 口腔扁平苔癬の病態解明/治療法開発に向けた多角的アプローチ

    2022.1 - 2025.3

    日本 

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    Authorship:Principal investigator 

  • IgG4関連疾患、木村氏病およびCOVID-19におけるクラススイッチ機構の解明

    Grant number:22H03290  2022 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • IgG4関連疾患、木村氏病およびCOVID-19におけるクラススイッチ機構の解明

    Grant number:22H03290  2022 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腫瘍微小環境におけるPAR1を介した口腔癌の高度悪性形質獲得機構の解明

    Grant number:22K10222  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 九州大学 SENTAN-Q Project

    2022

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    Grant type:Donation

  • 新型コロナウイルス感染症における疾患特異的T細胞およびB細胞の病態との関連 International coauthorship

    2021.10 - 2027.3

    九州大学大学院 歯学研究院 口腔顎顔面病態学講座 顎顔面腫瘍制御学分野 

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    Authorship:Principal investigator 

  • Expansion of CD4+ cytotoxic T lymphocytes and IgD-CD27- double negative B cells in COVID-19 and autoimmune diseases including IgG4-related disease

    2021 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

  • Expansion of CD4+ cytotoxic T lymphocytes and IgD-CD27- double negative B cells in COVID-19 and autoimmune diseases including IgG4-related disease.

    2021 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fostering Joint International Research (B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新型コロナウイルス感染症における細胞障害性CD4+T細胞とダブルネガティブB細胞の病態との関連

    2021 - 2022

    科学研究費助成事業  先進医薬健康財団 研究助成金

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 研究活動スタート支援

    2017 - 2022

    科学研究費助成事業  若手研究(スタートアップ)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 口腔扁平上皮癌の悪性転化および上皮-間葉転換を介した転移におけるKLK6の役割

    2017 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

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Educational Activities

  • Undergraduate Student education
    Resident Education
    Graduate Students education

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2021  福岡医健専門学校(歯科衛生士)の非常勤講師を務めている。  Domestic/International Classification:Japan 

Participation in international educational events, etc.

  • 2021.7

    九州大学

    SENTAN-Q Project (ダイバーシティ・スーパーグローバル教員育成研修)

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    Venue:日本

    Number of participants:11

Other educational activity and Special note

  • 2021  Coaching of Students' Association 

Outline of Social Contribution and International Cooperation activities

  • 社会貢献:学外の医療系専門学校における講義、開業歯科医院での口腔外科手術指導
    国際連携活動:新型コロナウイルス感染症と各種自己免疫疾患の病態解明に向けた国際共同研究 (ハーバード大学、マサチューセッツ総合病院、Ragon Institute of MGH, MIT and Harvard)

Social Activities

  • 非常勤講師

    福岡医健専門学校.  2021.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Travel Abroad

  • 2023.1 - 2023.3

    Staying countory name 1:United States   Staying institution name 1:Harvard University, RagonInstitute

  • 2018.4 - 2021.3

    Staying countory name 1:United States   Staying institution name 1:Ragon Institute of MGH, MIT and Harvard

    Staying institution name 2:Harvard Medical School

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Dentistry / Surgical Dentistry

Clinician qualification

  • Certifying physician

    日本口腔外科学会

Year of medical license acquisition

  • 2012