GAO JING
Organization
Faculty of Dental Science Department of Dental Science Assistant Professor
School of Dentistry Department of Dentistry（Joint Appointment）
Graduate School of Dental Science
（Joint Appointment）
Graduate School of Dental Science Department of Dental Science（Joint Appointment）
Title
Assistant Professor
Contact information
Tel
0926426321
Profile
イノシトール 1,4,5-三リン酸結合蛋白質の機能解析を中心として、細胞生物学、分子生物学的手法を用いた実験により細胞内情報伝達に果たすイノシトールリン酸/イノシトールリン脂質の様々な役割について研究中。
External link
Degree
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Ph.D
Research Interests・Research Keywords
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Research theme：Role of PRIP in regulation of insulin signaling
Keyword：insulin signaling, insulin resistance,
Research period： 2015.4 - 2019.3
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Research theme：Phospho-regulation of exocytosis by protein complex formation
Keyword：SNARE, exocytosis, phosphorylation
Research period： 2013.4 - 2015.3
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Research theme：Roles of a Novel Molecule in Regulation of Exocytosis
Keyword：exocytosis, membrane lipid, calcium,SNARE complex
Research period： 2010.11 - 2013.3
Awards
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2023年度九大歯学優秀研究者賞
2024.2 九州大学歯学研究院 p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands
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「いい唾液の日」優秀論文賞
2023.11 特定非営利活動法人日本唾液ケア研究会 唾液学の基礎領域において、p130Casがアンドロゲン依存性の顆粒性導管の発生に重要な役割を果たすという、世界に先駆けた知見を公表し社会貢献しました。
Papers
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p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands. Invited Reviewed International journal
Gao J., #Li A., Fujii S., #Huang F., @Nakatomi C., @Nakamura I., @Honda H., Kiyoshima T., Jimi E.
Scientific reports 13 ( 1 ) 2023.3
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Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes Reviewed International journal
Gao J, Mizokami A, Takeuchi H, Li A, Huang F, Nagano H, Kanematsu T, Jimi E, Hirata M.
Journal of cell science 135 ( 1 ) 2022.1
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Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway Reviewed International journal
Gao J, Muroya R, Huang F, Nagata K, @Shin M, @Nagano R, @Tajiri Y, Fujii S, Yamaza T, @Aoki K, @Tamura Y, @Inoue M, Chishaki S, Kukita T, @Okabe K, Matsuda M, @Mori Y, Kiyoshima T, Jimi E.
Lab Invest. 101 ( 11 ) 1475 - 1483 2021.10
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p130Cas Induces Bone Invasion by Oral Squamous Cell Carcinoma by Regulating Tumor Epithelial-Mesenchymal Transition and Cell Proliferation Invited Reviewed International journal
@Tatsuki Yaginuma, Jing Gao, Kengo Nagata, Ryusuke Muroya, Huang Fei, #Haruki Nagano, Sakura Chishaki, Takuma Matsubara, Shoichiro Kokabu, Kou Matsuo, Tamotsu Kiyoshima, Izumi Yoshioka, Eijiro Jimi
Carcinogenesis 2020.1
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GLP-1 Signaling Is Required for Improvement of Glucose Tolerance by Osteocalcin Reviewed International journal
Akiko Mizokami, Satoru Mukai, Jing Gao, @Tomoyo Kawakubo-Yasukochi, @Takahito Otani, @Hiroshi Takeuchi, Eijiro Jimi, @Masato Hirata
the Journal of endocrinology 2019.11
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Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling. Reviewed International journal
Satoshi Asano, Yuri Taniguchi, Yosuke Yamawaki, Jing Gao, Kae Harada , Hiroshi Takeuchi, Masato Hirata, Takashi Kanematsu
Scientific Reports 7 ( 1 ) 2017.7
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Tomosyn is a novel Akt substrate mediating insulin-dependent GLUT4 exocytosis Invited Reviewed International journal
Koki Nagano, Hiroshi Takeuchi, Jing Gao, Yoshihide Mori, Takahito Otani, Daguang Wang, Hirata Masato
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 62 62 - 71 2015.5
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Hetero-oligomerization of C2 domains of phospholipase C-related but catalytically inactive protein and synaptotagmin-1 Reviewed International journal
Daguang Wang, Hiroshi Takeuchi, Jing Gao, Zhao Zhang, Masato Hirata
Advances in Biological Regulation 2015.1
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Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation Invited Reviewed International journal
Goro Sugiyama, Hiroshi Takeuchi, Takashi Kanematsu, Jing Gao, Miho Matsuda, Masato Hirata
Advanced in Biological Regulation 53 ( 3 ) 331 - 340 2013.7
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PRIP (Phospholipase C-related but Catalytically Inactive Protein) inhibits exocytosis by direct interactions with Syntaxin 1 and SNAP-25 through its C2 domain Reviewed International journal
Zhao Zhang, Hiroshi Takeuchi, Jing Gao, Daguang Wang, DeclanJ. James, Thomas F.J.Martin, Masato Hirata
The Journal of Biological Chemistry 288 ( 11 ) 7769 - 7780 2013.3
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Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice Reviewed International journal
Akiko Mizokami, Yu Yasutake, JingGao, Miho Matsuda, Ichiro Takahashi, Hiroshi Takeuchi, Masato Hirata
Plos One 8 ( 2 ) e57375 2013.2
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Phospholipase C-related but catalytically inactive protein (PRIP) modulates synaptosomal-associated protein 25 (SNAP-25) phosphorylation and exocytosis. Reviewed International journal
Jing Gao, Hiroshi Takeuchi, Zhao Zhang, Mitsunori Fukuda, Masato Hirata
The Journal of Biological Chemistry 287 ( 13 ) 2012.3
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Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Reviewed International journal
Takeuchi, H., Takeuchi, T., Gao, J., Cantley, LC. and Hirata, M.
Molecular and Cellular Biology 30 ( 7 ) 2010.4
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Assay of dense-core vesicle exocytosis in permeabilized PC12 cells International journal
Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. and Hirata, M.
Andvances in Enzyme Regulation 50 2010.1
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Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain. Reviewed International journal
Gao, J., Takeuchi, H., Zhang, Z., Fujii, M., Kanematsu, T. and Hirata, M.
Cellular Signalling 21 2009.3
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The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K/Akt/NFB pathway in osteosarcoma cells. Reviewed International journal
146 ( 5 ) 633 - 641 2005.11
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Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis Reviewed International journal
#Inoue A, Kiyoshima T, Yoshizaki K, @Nakatomi C, @Nakatomi M, @Ohshima H, @Shin M, Gao J, @Tsuru K, @Okabe K, @Nakamura I, @Honda H, Matsuda M, Takahashi I, Jimi E.
Bone 154 ( 116210 ) 2022.1
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Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis Reviewed International journal
Mukai S, Mizokami A, Otani T, Sano T, Matsuda M, Chishaki S, Gao J, Kawakubo-Yasukochi T, Tang R, Kanematsu T, Takeuchi H, Jimi E, Hirata M.
Journal of biological chemistry 296 ( 100274 ) 2021.1
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Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis Reviewed
Kenya Touyama, Masud Khan, Kazuhiro Aoki, Miho Matsuda, Fumitaka Hiura, Nana Takakura, Takuma Matsubara, Yui Harada, Yuna Hirohashi, Yukihiko Tamura, Jing Gao, Kayo Mori, Shoichiro Kokabu, Hisataka Yasuda, Yuko Fujita, Koji Watanabe, Yoshinori Takahashi, Kenshi Maki, Eijiro Jimi
Journal of Cellular Biochemistry 120 ( 11 ) 18793 - 18804 2019.11
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An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration Reviewed International journal
Akiko Mizokami, Daguang Wang, Mitsuru Tanaka, Jing Gao, Hiroshi Takeuchi, Toshiro Matsui, Masato Hirata
Bioscience, Biotechnology, and Biochemistry 27 1 - 8 2016.6
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Differential role of SNAP-25 phosphorylation by protein kinases A and C in the regulation of SNARE complex formation and exocytosis in PC12 cells Invited Reviewed International journal
CELLULAR SIGNALLING 28 ( 5 ) 425 - 437 2016.5
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Signaling pathway for adiponectin expression in adipocytes by osteocalcin Reviewed International journal
Takahito Otani, Akiko Mizokami, Yoshikazu Hayashi, Jing Gao, Yoshihide Mori, Seiji Nakamura, Hiroshi Takeuchi, Masato Hirata
CELLULAR SIGNALLING 27 ( 3 ) 533 - 544 2015.3
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Regulated interaction of protein phosphatase 1 and protein phophatase 2A with phospholipase C-related but catalytically inactive protein Reviewed International journal
Goro Sugiyama, Hiroshi Takeuchi, Koki Nagano, Jing Gao, Yukiko Ohyama, Yoshihide Mori, Masato Hirata
Biochemistry 51 ( 16 ) 3394 - 3403 2012.4
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Second basic pockets contribute to the localization of PX domains by binding to phosphatidic acid Reviewed International journal
Hiroshi Takeuchi , Zhao Zhang, Jing Gao, Goro Sugiyama, Takako Takeuchi, Masato Hirata
Advances in Biological Regulation 52 ( 1 ) 2012.1
Presentations
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骨格筋形成におけるPRIPの役割の解明
高靖、松田美穂、#李傲男、#黄菲、溝上顕子、自見英治郎
第９６回日本生化学会大会 2023.10
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マウス唾液腺の機能発現におけるp130Casの役割
高 靖 , #李傲男, 藤井 慎介, 清島 保, 自見 英治郎
第94回日本生化学会大会 2021.11
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＃井上茜、 高靖、吉崎恵悟、＠進正史、＠中富千尋、＠中富満城、＠岡部 幸司、＠大島勇人、 高橋一郎 、自見英治郎
第６２回歯科基礎医学会学術大会 2020.9
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脂肪細胞のインスリンシグナリングの調節におけるPRIPの役割
高靖、溝上顕子、＠竹内弘、自見英治郎、＠平田雅人
第４２回日本分子生物学会年会 2019.12
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Jing Gao, Akiko Mizokami, @Hiroshi Takeuchi, Ejiro Jimi and @Masato Hirata
2018.9
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高 靖, 溝上 顕子, 竹内 弘, 自見 英治郎, 平田 雅人
第６０回歯科基礎医学会学術大会 2018.9
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インスリン受容体基質のリン酸化制御におけるPRIPの役割
2017年度生命科学系学会合同年次大会 2017.12
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Phospholipase C-related but Catalytically Inactive Protein, PRIP is involved in the regulation of insulin signaling via IRS-1/Akt pathway by modulating serine phosphorylation of IRS-1 International conference
Jing Gao, Akiko Mizokami, Masato Hirata
2016 American Society for Cell Biology Annual Meeting 2016.12
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Differential role of SNAP-25 phosphorylation by Protein Kinase A and C in the regulation of SNARE complex formation and exocytosis International conference
Jing Gao, Akiko Mizokami, Hiroshi Takeuchi, Masato Hirata
The 23rd General Meeting of the Japanese Association for Dental Science 2016.10
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SNARE複合体形成と開口分泌調節におけるSNAP-25リン酸化の役割
Jing Gao, 平田牧子, 溝上 顕子, 竹内 弘, 平田 雅人
第５８回歯科基礎医学会学術大会 2016.8
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2015.12
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SNAP-25 Phosphorylation by Protein Kinase-A and -C is Differentially Involved Exocytosis through the Regulation of SNARE Complex Formation
2015.5
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Phosphorylation of SNAP-25 by protein kinase-A is negatively involved in calcium-dependent exocytosis in PC12 cells
Jing Gao, Hiroshi Takeuchi, Daguang Wang, Masato Hirata
2014.10
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Phospho-dependent Regulation of Exocytosis Invited
Jing Gao, Hiroshi Takeuchi, Masato Hirata
2013.9
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Differential Role of SNAP-25 phosphorylation by protein kinase-A and –C in SNARE complex formation
第８６回日本生化学大会 2013.9
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SNAP-25 phosphorylation causes down-regulation of SNARE complex formation.
Jing Gao, Hiroshi Takeuchi, Zhao Zhang, Daguang Wang, Masato Hirata
2012.12
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Role of SNAP-25 phosphorylation by protein kinase A in SNARE complex formation. International conference
Jing Gao, Hiroshi Takeuchi, zhao zhang, Daguang Wang, Masato Hirata
The 22nd IUBMB & 37th FEBS Congress 2012.9
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Roles of PRIP in phospho-regulation of exocytosis through the interaction with protein phosphatases Invited International conference
Jing Gao, Hiroshi Takeuchi, Zhao Zhang, Goro Sugiyama, Koki Nagano and Masato Hirata
The 7th Korea-Japan Conference on Cellular Signaling for Young Scientist 2012.2
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Phospho-dependent modulation of exocytosis by PRIP International conference
Jing Gao, Hiroshi Takeuchi, Zhao Zhang, Goro Sugiyama, Koki Nagano, Masato Hirata
The 10th JBS Biofrontier Symposium on New Aspects of Phospholipid Biology and Medicine 2011.11
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Involvement of PRIP in Exocytosis through phospho-dependent regulation of SNAP-25
Jing Gao, Hiroshi Takeuchi, Zhao Zhang, Goro Sugiyama, Masato Hirata
2011.9
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Implication of PRIP in phospho-denpendent regulation of exocytosis.
Gao Jing, Takeuchi Hiroshi, Zhang ZHao, Hirata Masato.
2010.12
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Regulatory role of PRIP in exocytosis through the interaction with protein phosphatase. International conference
Gao Jing, Takeuchi Hiroshi, Zhang Zhao and Hirata Masato.
The 12th IUBMB, 21st FAOBMB &ComBio2010 Conferences 2010.9
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The regulatory mechanism of NF-kB signals involved in postmenopausal osteoporosis and weight gain.
2022.9
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2022.9
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p130Cas はマウス顎下腺の顆粒性導管の発達に関与する
＃李傲男、高靖、藤井慎介、清島保、自見英治郎
第63回歯科基礎医学会学術大会 2021.10
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NF-κB，p65 の 534 番目のリン酸化は閉経後骨粗鬆症と体重増加に関与する
#黄菲、高靖、自見英治郎
第63回歯科基礎医学会学術大会 2021.10
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唾液腺の形態形成及び機能発現における p130Cas の役割
室屋 龍佑，高 靖，＠中富 千尋，藤井 慎介，清島 保，自見英治郎
第６１回歯科基礎医学会学術大会 2019.10
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唾液腺の発生及び機能発現におけるp130Casの役割
＃室屋 龍佑, 高 靖, ＠中富 千尋, 藤井 慎介, 清島 保, 自見 英治郎
第６０回歯科基礎医学会学術大会 2018.9
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Involvement of Phospholipase C-related but Catalytically Inactive Protein, PRIP in the Regulation of Insulin Signaling International conference
Aya Nishikawa, Jing Gao, Akiko Mizokami, Makiko Hirata, Masato Hirata
The 9th KOREA-JAPAN Conference on Cellular Signaling for Young Scientists 2016.7
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Phosphorylation of tomosyn by Akt is implicated in the regulation of GLUT4 translocation International conference
Koki Nagano, Hiroshi Takeuchi, Jing Gao, Takahito Otani, Masato Hirata
The 8th Japan-Korea Conference on Cellular Signaling for Young Scientists 2013.11
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Osteocalcin induces release of glucagon-like peptide-1 and improves metabolic state in mice Invited International conference
Akiko Mizokami, Yu Yasutake, Jing Gao, Hiroshi Takeuchi, Masato Hirata
The 8th Japan-Korea Conference on Cellular Signaling for Young Scientists 2013.11
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Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation. Invited International conference
2013.7
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Phopholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation. Invited International conference
Masato Hirata, Goro Sugiyama, Jing Gao, Hiroshi Takeuchi
The 39th European Symposium on Hormones and Cell Regulation. 2014.10
Professional Memberships
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The Japanese Biochemical Society
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The Japanese Biochemical Society
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Japansese Association for Oral Biology
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The Molecular Biology Society of Japan
Academic Activities
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秘書 International contribution
2013.11
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秘書 International contribution
2011.11
Research Projects
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神経細胞のメンブレントラフィックにおけるp130Casの役割の解明
Grant number：24K12871 2024 - 2026
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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NMT1結合分子によるミリストイル化を介した骨免疫機能調節機構の解明
Grant number：23792432 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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唾液腺の発生におけるp130Casの生理的役割の解明
Grant number：19K10054 2019 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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PRIPが制御するインスリンシグナルの解明
Grant number：16K11479 2016 - 2019
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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メタボリックシンドロームに関わるインスリンシグナルの解明ーPRIP作用を絡めてー
Grant number：27506 2015 - 2016
科学研究費助成事業 平成２７年度 九州大学教育研究プログラム・研究拠点形成プロジェクト（Ｐ＆Ｐ）
Authorship：Principal investigator Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
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タンパク質複合体によるリン酸化制御機構の解明
Grant number：25861758 2013 - 2015
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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開口分泌を調節する新規分子の役割解明研究
2011.4 - 2013.3
九州大学 歯学研究院
Authorship：Coinvestigator(s)
我々の見出した新規分子 PRIP の既知の機能を切り口として各開口分泌調節分子との関係を主として解析し、PRIPが分泌過程のどこに作用するのかを明らかにする。「開口分泌」というキーワードで表される小胞輸送や膜融合は、ホルモンやサイトカン、オータコイド、消化酵素の分泌、さらには神経伝達物質の放出に関わることは勿論のこと、受容体やチャネル、トランスポーターの細胞膜上への発現にも働いている。したがって、本研究成果は普遍的な細胞機能の１つに新しい分子の存在と役割を認知させるという学術的意義を持つ。同時に本研究成果は開口分泌（膜融合）の異常による疾患（内分泌異常、外分泌異常、受容体やトランスポーターの発現異常などに基づく疾病など幅広い）の病態の理解に進歩をもたらし、治療ターゲットに新しい分子を付け加えることになる。
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開口分泌モデルを用いた新規分子のリン酸化制御における役割解明研究
Grant number：23792127 2011 - 2013
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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開口分泌モデルを用いた新規分子のリン酸化制御における役割解明研究
Grant number：23792127 2011 - 2012
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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新規分子 PRIP の開口分泌における役割の解明
2011 - 2012
財団法人日中医学協会２０１１年度共同研究助成金
Authorship：Principal investigator Grant type：Contract research
Class subject
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口腔生化学
2023.4 - 2024.3 Full year
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口腔細胞工学
2023.4 - 2024.3 Full year
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口腔細胞工学演習
2023.4 - 2024.3 Full year
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口腔細胞工学演習
2022.4 - 2023.3 Full year
-
口腔生化学
2022.4 - 2023.3 Full year
-
リサーチエクスポージャ
2022.4 - 2023.3 Full year
-
口腔細胞工学
2022.4 - 2023.3 Full year
-
口腔細胞工学演習
2021.4 - 2022.3 Full year
-
口腔生化学
2021.4 - 2022.3 Full year
-
リサーチエクスポージャ
2021.4 - 2022.3 Full year
-
口腔細胞工学
2021.4 - 2022.3 Full year
-
口腔細胞工学演習
2020.4 - 2021.3 Full year
-
口腔生化学
2020.4 - 2021.3 Full year
-
リサーチエクスポージャ
2020.4 - 2021.3 Full year
-
口腔細胞工学
2020.4 - 2021.3 Full year
-
口腔細胞工学演習
2019.4 - 2020.3 Full year
-
口腔生化学
2019.4 - 2020.3 Full year
-
リサーチエクスポージャ
2019.4 - 2020.3 Full year
-
口腔細胞工学
2019.4 - 2020.3 Full year
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口腔細胞工学演習
2018.4 - 2019.3 Full year
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口腔生化学
2018.4 - 2019.3 Full year
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口腔細胞工学
2018.4 - 2019.3 Full year
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リサーチエクスポージャ
2018.4 - 2018.9 First semester
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口腔細胞工学演習
2017.4 - 2018.3 Full year
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リサーチエクスポージャ
2017.4 - 2018.3 Full year
-
口腔生化学
2017.4 - 2018.3 Full year
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口腔細胞工学
2017.4 - 2018.3 Full year
-
口腔生化学
2016.4 - 2017.3 Full year
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口腔細胞工学演習
2016.4 - 2017.3 Full year
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口腔細胞工学
2016.4 - 2017.3 Full year
-
口腔細胞工学演習
2015.4 - 2016.3 Full year
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口腔生化学
2015.4 - 2016.3 Full year
-
口腔細胞工学
2015.4 - 2016.3 Full year
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アーリーエクスポージャⅡ
2015.4 - 2015.9 First semester
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口腔細胞工学演習
2014.4 - 2015.3 Full year
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口腔生化学
2014.4 - 2015.3 Full year
-
口腔細胞工学
2014.4 - 2015.3 Full year
-
アーリーエクスポージャⅡ
2014.4 - 2014.9 First semester
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口腔細胞工学演習
2013.4 - 2014.3 Full year
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歯学総論Ⅰ
2013.4 - 2014.3 Full year
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口腔生化学
2013.4 - 2014.3 Full year
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口腔細胞工学
2013.4 - 2014.3 Full year
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アーリーエクスポージャⅡ
2013.4 - 2013.9 First semester
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口腔生化学
2012.4 - 2013.3 Full year
-
口腔細胞工学
2012.4 - 2013.3 Full year
-
口腔細胞工学演習
2012.4 - 2013.3 Full year
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歯学総論III
2012.4 - 2012.9 First semester
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歯学総論III
2011.10 - 2012.3 Second semester