HARADA YUI
Organization
Faculty of Pharmaceutical Sciences Associate Professor
Title
Associate Professor
Contact information
Tel
0926426337
External link
Degree
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Ph.D.
Research Interests・Research Keywords
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Research theme： Development of Immune Cell-based Therapies for Malignant Tumors, Enhancement of Cell Functions without Genetic Modification, and Development of Novel Protein Formulations with Highly Potent Antitumor Effects
Keyword： Cancer, Solid Tumors, Regenerative Medicine Products, Protein Formulations, Antibody-Drug Conjugates (ADCs), Dendritic Cells, NK Cells, Peritoneal Dissemination
Research period： 2006.4 - 2025.9
Awards
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Travel Grant
2019.10 The 18th Meeting of the Society for Natural Immunity, AFFIMED
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第28回日本消化器癌発生学会 研究奨励賞
2017.11
Papers
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固形腫瘍の治療を可能にするoff-the-shelf他家NK-like細胞の開発
原田 結
Seibutsu-kogaku Kaishi 101 ( 12 ) 623 - 627 2023.12 （ ISSN:09193758 eISSN:24358630 ）
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Xin, YF; Harada, Y; Wada, KI; Morodomi, Y; Yonemitsu, Y
MOLECULAR THERAPY 31 ( 4 ) 784 - 785 2023.5 （ ISSN:1525-0016 eISSN:1525-0024 ）
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第5土曜特集 mRNAワクチンやゲノム編集で注目が集まる遺伝子治療 遺伝子治療技術を用いた疾患治療 肺癌に対する免疫細胞治療
諸富 洋介, 原田 結, 米満 吉和
医学のあゆみ 285 ( 5 ) 440 - 445 2023.4 （ ISSN:00392359 ）
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Generation of transmitochondrial cybrids using a microfluidic device
Wada, KI; Hosokawa, K; Ito, Y; Maeda, M; Harada, Y; Yonemitsu, Y
EXPERIMENTAL CELL RESEARCH 418 ( 1 ) 2022.9 （ ISSN:0014-4827 eISSN:1090-2422 ）
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Generation of transmitochondrial cybrids using a microfluidic device Invited Reviewed International journal
Wada K, Hosokawa K, Ito Y, Maeda M, Harada Y, Yonemitsu Y.
Exp Cell Res 2022.6
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Fc-binding antibody-recruiting molecules targeting prostate-specific membrane antigen: defucosylation of antibody for efficacy improvement Reviewed International journal
Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y.
ChemBioChem 22 496 - 500 2021.6
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Highly activated ex vivo-expanded natural killer cells in patients with solid tumors in a Phase I/IIa clinical study Reviewed International journal
Nagai K, Harada Y, Harada H, Yanagihara K, Yonemitsu Y, Miyazaki Y.
Anticancer Res. 5687 - 5700 2020.6
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Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis Invited Reviewed International journal
Touyama K, Khan M, Aoki K, Matsuda M, Hiura F, Takakura N, Matsubara T, Harada Y, Hirohashi Y, Tamura Y, Gao J, Mori K, Kokabu S, Yasuda H, Fujita Y, Watanabe K, Takahashi Y, Maki K, Jimi E
J Cell Biochem 2019.6
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miR-3148 is a novel onco-microRNA that potentiates tumor growth in vivo. Invited Reviewed International journal
Akamine T, Morodomi Y, Harada Y, Teraishi K, Tagawa T, Okamoto T, Maehara Y, Yonemitsu Y.
Anticancer Res 2018.10
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Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression. Invited Reviewed International journal
Kawakubo N, Harada Y*, Ishii M, Souzaki R, Kinoshita Y, Tajiri T, Taguchi T, Yonemitsu Y.
Biochem Biophys Res Commun 2018.9
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Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells Invited Reviewed International journal
Iwai T, Harada Y, Saeki H, Oki E, Maehara Y, Yonemitsu Y.
Oncotarget 2018.4
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Phospholipase C-related, but catalytically inactive protein (PRIP) upregulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling. Invited Reviewed International journal
Murakami A, Matsuda M, Harada Y, Hirata M.
Journal of Biological Chemistry 2017.5
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BubR1 insufficiency results in decreased macrophage proliferation and attenuated atherogenesis in apolipoprotein E-deficient mice. Invited Reviewed International journal
Tanaka S, Matsumoto T, Matsubara Y, Harada Y, Kyuragi R, Koga J, Egashira K, Nakashima Y, Yonemitsu Y, Maehara Y.
Journal of the American Heart Association 2016.9
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Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and extracellular matrix-directed spheroid formation. Invited Reviewed International journal
Kasagi Y*, Harada Y*, Morodomi Y, Saito S, Yoshida K, Oki E, Saeki K, Ohgaki K, Sugiyama M, Onimaru M, Maehara Y, Yonemitsu Y.
Cancer Research 2016.1
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Effective recovery of highly purified CD326+ tumor cells from lavage fluid of patients treated with a novel cell-free and concentrated ascites reinfusion therapy (KM-CART). Invited Reviewed International journal
Kimura Y, Harada Y*, Yasuda N, Ishidao T, Yusa S, Matsusaki K, Yonemitsu Y.
SpringerPlus 2015.12
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BubR1 insufficiency impairs vascular smooth muscle cell proliferation and inhibits neointimal hyperplasia in mice. Invited Reviewed International journal
Kyuragi R, Matsumoto T, Harada Y, Saito S, Onimaru M, Nakatsu Y, Tsuzuki T, Nomura M, Yonemitsu Y, Maehara Y.
Arteriosclerosis Thrombosis and Vascular Biology 2015.3
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Ex vivo generation of highly purified and activated NK cells from human peripheral blood. Invited Reviewed International journal
Saito S, Harada Y, Morodomi Y, Onimaru M, Yoshida K, Matsubara H, Yonemitsu Y.
Human Gene Therapy Method 2013.8
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BioKnife, a uPA Activity-dependent Oncolytic Sendai Virus, Eliminates Pleural Spread of Malignant Mesothelioma via Simultaneous Stimulation of uPA Expression.
Morodomi Y, Yano T, Kinoh H, Harada Y, Saito S, Kyuragi R, Yoshida K, Onimaru M, Shoji F, Yoshida T, Ito K, Shikada Y, Maruyama R, Hasegawa M, Maehara Y, Yonemitsu Y.
Molecular Therapy 2012.2
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Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells.
Harada Y, Okada-Nakanishi Y, Ueda Y, Tsujitani S, Saito S, Fuji-Ogawa T, Iida A, Hasegawa M, Ichikawa T, Yonemitsu Y.
Scientific Reports 2011.11
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Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites.
Sugiyama M, Kakeji Y, Tsujitani S, Harada Y, Onimaru M, Yoshida K, Tanaka S, Emi Y, Morita M, Morodomi Y, Hasegawa M, Maehara Y, Yonemitsu Y.
Molecular Cancer Therapy 2011.3
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RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer.
Kato T, Ueda Y, Kinoh H, Yoneyama Y, Matsunaga A, Komaru A, Harada Y, Suzuki H, Komiya A, Shibata S, Hasegawa M, Hayashi H, Ichikawa T and Yonemitsu Y.
Neoplasia 2010.11
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Urokinase-targeted cell-cell fusion by oncolytic Sendai virus eradicates orthotropic model of glioblastomas by a pronounced synergy with interferon-beta.
Hasegawa Y, Kinoh H, Iwadate Y, Ueda Y, Harada Y, Saito S, Furuya A, Saegusa K, Morodomi Y, Hasegawa M, Aoki I, Saeki N, Yonemitsu Y.
Molecular Therapy 2010.10
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Carbon ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma.
Matsunaga A, Ueda Y, Yamada S, Harada Y, Shimada H, Hasegaw M, Tsuji H, Ochiai T, Yonemitsu Y.
Cancer 2010.8
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Sustained and NK/CD4+ T Cell-Dependent Efficient Prevention of Lung Metastasis Induced by Dendritic Cells Harboring Recombinant Sendai Virus.
Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, Kinoh H, Harada Y, Suzuki H, Inoue M, Hasegawa M, Ichikawa T and Yonemitsu Y.
J Immunol 2009.10
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Cytokine-based log-scale expansion of functional murine dendritic cells.
Harada Y, Ueda Y, Kinoh H, Komaru A, Fuji-Ogawa T, Furuya A, Iida A, Hasegawa M, Ichikawa T, Yonemitsu Y.
PLos ONE 2009.8
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Genetic heterogeneity of the cytolethal distending toxin B (cdtB) gene locus among isolates of Campylobacter lari.
Shigematsu M, Harada Y, Sekizuka T, Murayama O, Takamiya S, Millar BC, Moore JE, and Matsuda M.
Br J Biomed Sci 2006.10
Books
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『生物工学会誌』 固形腫瘍の治療を可能にする off-the-shelf 他家 NK-like 細胞の開発
原田 結
2023.12
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（単行本）『Geriatric Medicine (老年医学)』 第7章 ワクチン・感染症での免疫機能の役割
原田 結、米満吉和
2022.6
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（単行本）『分子細胞治療フロンティア2020』（外科分子細胞治療研究会編） 第２章 細胞治療の新しい展開
原田 結、米満吉和
2019.6
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Clinical Applications of Natural Killer Cells Ed. by Mourad Aribi, Natural Killer Cells.
Harada Y, Teraishi K, Ishii M, Ban H, Yonemitsu Y.（Role：Joint author）
InTech Open. 2017.12
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（単行本）『パラダイムシフトをもたらすエクソソーム機能研究最前線』（落谷孝広編） 第１章 エクソソーム分離精製技術
松田大介、原田 結（Role：Joint author）
(株)エヌ・ティー・エス 2017.3
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（単行本）『分子細胞治療フロンティア2015』（外科分子細胞治療研究会編） 第５章 悪性胸膜中皮腫に対する遺伝子治療の現状と今後の展望
諸富洋介、岡本龍朗、原田 結、長谷川護、前原喜彦、米満吉和（Role：Joint author）
飯田橋パピルス社 2014.8
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（単行本）『分子細胞治療フロンティア2015』（外科分子細胞治療研究会編） 第４章 悪性腫瘍に対する樹状細胞によるがんワクチンの開発
原田 結、米満吉和（Role：Joint author）
飯田橋パピルス社 2014.8
Presentations
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がんに対する免疫療法のための樹状細胞の増幅
原田 結、上田泰次、石田久美、加藤智規、小丸 淳、喜納宏昭、松永晃直、市川智彦、米満吉和
第7回 シンポジウム 遺伝子・デリバリー研究会 2007.5
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Generation of a large number of mature dendritic cells in vitro
Harada Y, Ueda Y, Ishida K, Kato T, Komaru A, Kinoh H, Matsunaga A, Ichikawa T, Yonemitsu Y
The 13th Annual Meeting of JSGT 2007.6
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Cytokine-based log-scale expansion of functional murine dendritic cells International conference
Harada Y, Ueda Y, Sugimoto T, Kinoh H, Komaru A, Iida A, Hasegawa M, Seki N, Ichikawa T, Yonemitsu Y.
American society of Gene Therapy 11th Annual meeting 2008.5
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Cytokine-based log-scale expansion of functional murine dendritic cells
Harada Y, Ueda Y, Sugimoto T, Kinoh H, Komaru A, Inoue M, Hasegawa M, Seki N, Ichikawa T, Yonemitsu Y.
The 14th Annual Meeting of JSGT 2008.6
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Cytokine-based log-scale expansion of functional murine dendritic cells
Harada Y, Ueda Y, Kinoh H, Yonemitsu Y
11th LIPOSOME RESEARCH DAYS CONFERENCE 2008.7
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Young Investigator Award
Harada Y, Ueda Y, Kinoh H, Komaru A, Ogawa T, Iida A, Hasegawa M, Ichikawa T, Yonemitsu Y.
The 10th International Symposium on Dendritic Cells 2008.10
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Cytokine-based log-scale expansion of functional human dendritic cells
Harada Y, Ueda Y, Kinoh H, Komaru A, Fuji-Ogawa T, Furuya A, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y
The 15th Annual Meeting of JSGT 2009.7
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Cytokine-based log-scale expansion of functional human dendritic cells International conference
Harada Y, Ueda Y, Kinoh H, Komaru A, Fuji-Ogawa T, Furuya A, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y
American society of Gene and Cell Therapy 13th Annual meeting 2010.5
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Cytokine-based log-scale expansion of functional human dendritic cells
Harada Y, Ueda Y, Yonemitsu Y
第14回日本がん免疫学会 2010.7
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Search for a key molecule of dendritic cell differentiation
Harada Y, Ueda Y, Yoshida K, Ichikawa T, Yonemitsu Y
The 16th Annual Meeting of JSGT 2010.7
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Cytokine-based log-scale expansion of functional human dendritic cells International conference
Harada Y, Ueda Y, Saito S, Furuya A, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y
The 11th International Symposium on Dendritic Cells 2010.9
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Cytokine-based log-scale expansion of functional human dendritic cells from PBMCs
Harada Y, Saito S, Ichikawa T, Yonemitsu Y
American society of Gene and Cell Therapy 14th Annual meeting 2011.5
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Cytokine-based log-scale expansion of functional human dendritic cells from PBMCs
Harada Y, Ueda Y, Saito S, Ichikawa T, Yonemitsu Y
The 17th Annual Meeting of JSGT 2011.7
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Cytokine-based log-scale expansion of functional human dendritic cells from PBMC
Harada Y, Saito S, Yonemitsu Y
The 2nd Meeting of ACTO 2011.10
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Cytokine-based log-scale expansion of functional human dendritic cells of cancer patients
Harada Y, Tsujitani S, Tanii M, Yonemitsu Y
The 12th International Symposium on Dendritic Cells 2012.10
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Identification of mesenteric hematopoiesis where is the metastatic niche of tumor dissemination
The 19th Annual Meeting of JSGT
2013.6
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腹膜播種がん幹細胞様細胞が足場とするニッシェ様細胞の同定とその標的化
Harada Y, Morodomi Y, Yonemitsu Y
The 72nd Japanese Cancer Association 2013.10
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Molecular and Cellular Mechanism of Tumor Dissemination in the Peritoneal Cavity
Harada Y, Morodomi Y, Kasagi Y, Saito S, Yonemitsu Y
The 22nd European Society of Gene and Cell Therapy 2013.10
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Molecular and cellular mechanism of tumor dissemination in the peritoneal cavity
Harada Y, Morodomi Y, Kasagi Y, Yonemitsu Y
The 20th Annual Meeting of JSGT 2014.8
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Mass-production of human dendritic cells in accordance with GMP for clinical studies International conference
Harada Y, Yasuda N, Yonemitsu Y
The 13th International Symposium on Dendritic Cells 2014.9
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Molecular and Cellular Mechanism of Directed Tumor Dissemination in the Peritoneal Cavity
Harada Y, Kasagi Y, Morodomi Y, Yonemitsu Y.
The 73rd Japanese Cancer Association 2014.9
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Identification of mesenteric hematopoiesis where is the metastatic niche of tumor dissemination
Harada Y, Morodomi Y, Kasagi Y, Yonemitsu Y
The 25th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis, The 8th International Conference of the Society of Gastroenterological Carcinogenesis 2014.11
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Mass-production of human dendritic cells in accordance with GMP for clinical studies International conference
Harada Y, Yasuda N, Yonemitsu Y
Keystone Symposia: Dendritic Cells and Macrophages Reunited (C4) 2015.3
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Viral/transgene/feeder-free iPS cell-based functional hepatocytes
Harada Y, Yonemitsu Y
The 21st Annual Meeting of JSGT 2015.7
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Mass-production of human dendritic cells in accordance with GMP for clinical studies International conference
Harada Y, Yasuda N, Yonemitsu Y
Society for Immunotherapy of Cancer (SITC) 30th Anniversary Annual Meeting 2015.11
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Development of a novel therapeutic approach based on the mechanism of tumor dissemination
Harada Y, Teraishi K, Morodomi Y, Yamashita T, Tsuda M, Inoue K, Yonemitsu Y
The 26th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 2015.11
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Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Harada Y, Morodomi Y, Yonemitsu Y
The 22nd Annual Meeting of JSGCT 2016.7
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Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and sphere formation
Harada Y, Kasagi Y, Morodomi Y, Yonemitsu Y
The 75th Japanese Cancer Association 2016.10
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MEK 1/2 inhibition might be a potential strategy to treat peritoneal dissemination by inhibiting MDSCs
Harada Y, Teraishi K, Yonemitsu Y
The 27th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 2016.9
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Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis International conference
Takahashi H, ※Harada Y, Shigetaka Shimodaira, Masahiro Ogasawara, Shuichi Ota, Masanori Kobayashi, Hirofumi Abe, Yuji Morita, Kazuhiro Nagai, Shunichi Tsujitani, Masato Okamoto, Yukio Suzuki, Yoichi Nakanishi, and Yoshikazu Yonemitsu
The 14th International Symposium on Dendritic Cells 2016.10
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Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood in accordance with GMP/GCTP for clinical studies International conference
Harada Y, Yonemitsu Y
Society for Immunotherapy of Cancer (SITC) 31st Anniversary Annual Meeting 2016.11
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Viral/transgene/feeder-free iPS cell-based functional hepatocytes
Harada Y, Yonemitsu Y
The 16th Congress of the Japanese Society for Regenerative Medicine 2017.3
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Artificial liver based on viral/transgene/feeder-free iPS cell-derived functional hepatocytes
Harada Y, Yonemitsu Y
The 23rd Annual Meeting of JSGCT 2017.7
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Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood in accordance with GMP/GCTP for clinical studies International conference
Harada Y, Yonemitsu Y
The 2nd Innate Killer Summit 2017.7
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AdoptCell®-NK: Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood in accordance with GMP/GCTP for clinical studies International conference
Harada Y, Yonemitsu Y
Society for Immunotherapy of Cancer (SITC) 32nd Anniversary Annual Meeting 2017.11
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Development of novel NK cell-based immunotherapy for malignancies
Harada Y, Yonemitsu Y
The 28th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis, The 9th International Conference of the Society of Gastroenterological Carcinogenesis 2017.11
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AdoptCell®-NK: a new class NK cells manufactured in accordance with GMP/GCTP for clinical studies
Harada Y, Yonemitsu Y
The 17th Congress of the Japanese Society for Regenerative Medicine 2018.3
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Viral/transgene/feeder-free iPS cell-based extracorporeal-circulating artificial liver support
Harada Y, Yasuda N, Yonemitsu Y
The 17th Congress of the Japanese Society for Regenerative Medicine 2018.3
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AdoptCell®-NK: a Novel Natural Killer Cell Phenotype That Can Eliminate the Solid Tumors International conference
Harada Y, Yonemitsu Y
American society of Gene and Cell Therapy 21st Annual meeting 2018.5
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GAIA-102: a new class NK cells manufactured in accordance with GMP/GCTP that can eliminate the solid tumors
Harada Y, Yonemitsu Y
The 24th Annual Meeting of JSGCT 2018.7
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AdoptCell®-NK: a new class NK cells manufactured in accordance with GMP/GCTP that can eliminate the solid tumors International conference
Harada Y, Yonemitsu Y
Society for Immunotherapy of Cancer (SITC) 33rd Anniversary Annual Meeting 2018.11
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Development of innovative therapeutics for solid tumors
Harada Y, Yonemitsu Y
The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 2018.11
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AdoptCell®-NK: a new class NK cells manufactured in accordance with GMP/GCTP that can eliminate the solid tumors International conference
Harada Y, Yonemitsu Y
The 3rd Innate Killer Summit 2019.3
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がん免疫治療の最前線 〜GAIA-102: Allo-NK細胞製剤によるbreakthrough〜
Harada Y
Japan Surgical Society for Molecular and Cellular Therapy 21st Annual meeting 2019.4
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AdoptCell®-NK: a new class NK cells manufactured in accordance with GMP/GCTP that can eliminate the solid tumors International conference
Harada Y, Yonemitsu Y
American society of Gene and Cell Therapy 22nd Annual meeting 2019.9
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諸富 洋介, 金地 佐千子, Won Eric, 川本 忠文, 原田 結, 米満 吉和, 金地 泰典
日本血栓止血学会誌 2024.5 (一社)日本血栓止血学会
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Oki Eiji, Ota Mitsuhiko, Kawazoe Tetsuro, Tajiri Hirotada, Zaitsu Yoko, Nakanishi Ryota, Nakashima Yuichiro, Morodomi Yosuke, Harada Yui, Yoshizumi Tomoharu, Yonemitsu Yoshikazu
日本胃癌学会総会記事 2024.2 (一社)日本胃癌学会
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原田 結
日本がん免疫学会総会プログラム・抄録集 2023.6 日本がん免疫学会
MISC
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【革新的ながん免疫療法の実現を目指す分子技術開発の最前線】固形腫瘍の治療を可能にするoff-the-shelf他家NK-like細胞の開発
原田 結
生物工学会誌 101 ( 12 ) 623 - 627 2023.12 （ ISSN:0919-3758 ）
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【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】遺伝子治療技術を用いた疾患治療 肺癌に対する免疫細胞治療
諸富 洋介, 原田 結, 米満 吉和
医学のあゆみ 285 ( 5 ) 440 - 445 2023.4 （ ISSN:0039-2359 ）
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【超高齢社会における新興感染症ワクチン】ワクチン・感染症での免疫機能の役割
原田 結, 米満 吉和
Geriatric Medicine 60 ( 2 ) 135 - 139 2022.2 （ ISSN:0387-1088 ）
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がん細胞免疫療法の治療成績向上のための要素技術開発
原田 結、米満吉和
樹状細胞体外大量増幅技術開発とセンダイウイルスによる免疫刺激療法 2011.11
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Dramatic improvement of DC-based immunotherapy for various malignancies
Harada Y* and Yonemitsu Y.
Front Biosci 2011.6
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Recent developments in patented DC-based immunotherapy for various malignancies
Harada Y* and Yonemitsu Y.
Recent Patents on Regenerative Medicine 2011.1
Industrial property rights
| Patent | Number of applications: 38 | Number of registrations: 24 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
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日本遺伝子細胞治療学会（JSGCT）
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日本癌学会
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日本再生医療学会
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日本がん免疫学会
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日本バイオセラピィ学会
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日本消化器癌発生学会
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外科分子細胞治療研究会
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日本遺伝子細胞治療学会若手研究会
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日本抗加齢医学会
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日本免疫・細胞治療学会
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American Society of Gene & Cell Therapy: ASGCT
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Innate Killer Summit
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Society for Immunotherapy of Cancer: SITC
Committee Memberships
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日本遺伝子細胞治療学会（JSGCT） Councilor Domestic
2014.8 - Present
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外科分子細胞治療研究会 Organizer Domestic
2011.4 - Present
Academic Activities
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座長、大会事務局長
The 28th Annual Meeting of JSGCT, 2022、第28回 日本遺伝子細胞治療学会 （ Japan ） 2022.7
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学会座長
The 25th Annual Meeting of JSGCT, 2019、第25回 日本遺伝子細胞治療学会 （ Japan ） 2019.7
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学会座長
脳心血管抗加齢研究会2018 （ Japan ） 2018.12
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学会座長
The 21st Annual Meeting of JSGCT, 2015、第21回 日本遺伝子細胞治療学会 （ Japan ） 2015.7
Research Projects
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RNA 動的解析による固形腫瘍を破壊可能なGAIA-102の分化誘導機構の解明
2024.4 - 2029.3
Authorship：Coinvestigator(s)
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悪性腹水を伴うmicrosatellite stable（MSS）の進行期消化器癌（胃癌・膵癌）患者に対するGAIA-102 の腹腔内反復投与の臨床試験（第I/II 相医師主導治験）
2024.4 - 2029.3
Authorship：Coinvestigator(s)
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RNA 動的解析による固形腫瘍を破壊可能なGAIA-102の分化誘導機構の解明
Grant number：24H00643 2024.4 - 2029.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
米満 吉和, 原田 結, 諸富 洋介, 山崎 亮
Grant type：Scientific research funding
Memory-like NK(ML-NK)は、難治性急性骨髄性白血病AMLでの臨床試験において驚異的な治療効果を示すことから、いわゆるGVL効果の本態ではないかと注目されている。我々はこれらの動きとは全く独立に、固形がんへ極めて高い抗腫瘍活性を示す、「他家」NK細胞様製剤 GAIA-102を開発、固形腫瘍を対象に3つの治験を進めており、複数の症例で臨床的POCを示唆するデータを得ている。本研究では「ML-NK-like NK」とも呼び得るGAIA-102の分化系譜を明らかとし、なぜNK細胞にはこのようなバラエティに富んだスペクトラムがあるのかという免疫学の根源的な疑問に肉薄する事を目的とする。
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神経芽腫克服を目的とした高活性NK細胞製剤と抗PD-1抗体併用療法の開発
Grant number：24K10454 2024.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
石本 健太, 田尻 達郎, 川久保 尚徳, 米満 吉和, 原田 結, 諸富 洋介
Grant type：Scientific research funding
本研究は、神経芽腫に対する高活性NK細胞製剤(開発コード:GAIA-102)の抗腫瘍効果を強化するべく行われる前臨床試験である。GAIA-102は、他のNK細胞製剤と比較して歴然に優れた、固形がんへの高い浸潤能と傷害活性を示す。抗PD-1抗体を併用することで、より強力な免疫細胞誘導を生じると考えられ、神経芽腫に対するGAIA-102と抗PD-1抗体併用療法の有効性とメカニズムについて明らかにする。
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進⾏固形腫瘍を特異的かつ速やかに破壊する⾰新的⾮細胞製剤
2024.4 - 2026.3
Authorship：Principal investigator
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悪性腹水を伴う microsatellite stable(MSS)の進行期消化器癌(胃癌・膵癌)患者に対する GAIA-102 の腹腔内反復投与の医師主導治験 (PhaseI/II)
2024 - 2028
AMED 再生医療等実用化事業
Authorship：Coinvestigator(s) Grant type：Contract research
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進⾏固形腫瘍を特異的かつ速やかに破壊する⾰新的⾮細胞製剤
2024 - 2025
AMED シーズA
Authorship：Principal investigator Grant type：Contract research
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難治性神経芽腫根絶を目的とした効率的な低侵襲養子免疫治療の開発
Grant number：23K27662 2023.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
田尻 達郎, 原田 結, 馬庭 淳之介, 米満 吉和, 文野 誠久, 川久保 尚徳
Grant type：Scientific research funding
本研究は神経芽腫に対する革新的な免疫治療の開発を目的としている。これまでの研究で神経芽腫表面に発現するジシアロガングリシド（以下GD2）に対する抗体を搭載した間葉系幹細胞（GD2-MSCs）を開発し、神経芽腫自然発生モデルマウスにおいて高効率に神経芽腫にhomingし、なおかつADCC活性を誘導するメインエフェクターであるNatural Killer（以下NK）細胞の腫瘍内への誘導能を確認した。この研究を更に発展させるべく、共同研究施設で開発された高活性NK細胞様CD3陰性細胞をGD2-MSCと併用することを立案し、より効率的な養子免疫治療を実現する。
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リンパ球に固形腫瘍浸潤能を付与する非遺伝子改変修飾技術
2023.4 - 2025.3
Authorship：Principal investigator
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細胞に固形腫瘍浸潤能を付与する非遺伝子改変修飾技術
2023 - 2024
AMED シーズA
Authorship：Principal investigator Grant type：Contract research
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再発難治神経芽腫／その他の小児固形悪性腫瘍に対するNK 細胞様他家CD3 陰性細胞（GAIA-102）の安全性を検討する第Ⅰ相試験
2022.6 - 2025.3
Authorship：Coinvestigator(s)
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RNA velocity解析による新規NK細胞phenotype獲得機構の解明と医療応用
2022.4 - 2025.3
Authorship：Principal investigator
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Elucidation of novel NK cell activation and induction mechanisms by RNA velocity analysis
Grant number：23K24184 2022.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
原田 結
Grant type：Scientific research funding
これまでにNK細胞の増幅培養技術を開発、その臨床応用を進めるべく治験開始に向けて治験用製品を製造中である（治験実施中）。一方そのPhenotypeは臨床で高い有効性 (難治性AML15例に奏効率100%) を示したMemory-like NKと一部特徴を共有しつつも、特に固形腫瘍に対して高活性という点で特異である。その分化活性化機序を明らかにするべく研究を進めてきたが、その過程でGAIA-102がHeteroな集団で段階的に誘導されてくることを明らかにした。本研究ではその工程で鍵となる分子メカニズムを時間を追って明らかにするとともに、医療応用に向けた基盤データを取得する。
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RNA velocity解析による新規NK細胞誘導機構の解明と医療応用
Grant number：22H02923 2022 - 2024
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator Grant type：Scientific research funding
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RNA velocity解析による新規NK細胞phenotype獲得機構の解明と医療応用
2022 - 2024
Grants-in-Aid for Scientific Research (Ministry of Education, Culture, Sports, Science and Technology)
Authorship：Principal investigator Grant type：Contract research
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小児悪性固形腫瘍根絶を目的としたNK細胞様CD3陰性細胞を用いた革新的養子免疫治療法の開発
2022 - 2024
AMED シーズC
Authorship：Coinvestigator(s) Grant type：Contract research
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遺伝子改変を必要としない免疫細胞高機能化技術の開発
2022 - 2023
AMED シーズA
Authorship：Principal investigator Grant type：Contract research
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細胞洗浄濃縮装置の研究開発
2021.4 - 2025.3
Joint research
Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
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細胞洗浄濃縮装置の研究開発
2021.4 - 2025.3
Authorship：Principal investigator
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Elucidation of the function of the new NK cell subset and its application to adoptive immunotherapy
Grant number：21H04832 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
米満 吉和, 原田 結, 和田 健一
Grant type：Scientific research funding
我々はNK細胞の増幅培養技術を開発、開発コード:GAIA-102と命名、2021年の治験開始へ向け治験用製品を製造中である。一方、GAIA-102は既知のNK細胞のいずれのフェノタイプとも異なり、その特徴から ‘Emergency NK’という全く新しい観点から研究を進めて来たが、その過程でGAIA-102が ‘memory-like NK’と呼ばれる新しいNK細胞のカテゴリーを満たす(同一ではない) ことを見出した。本研究では、この‘Emergency NK’の生物学的な意義とその特性を特にmemory-like NKとの異同の観点から解析し、臨床応用のための基盤データを取得する。
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独自に発見した全く新しいphenotypeのNK様細胞を用いた養子免疫技術の実用化開発：第I相医師主導治験
2021 - 2023
AMED シーズC
Authorship：Coinvestigator(s) Grant type：Contract research
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抗体医薬の問題を解決し 、これを代替する新しい医薬の開発
2021 - 2023
キヤノン財団 新産業を生む科学技術
Authorship：Coinvestigator(s) Grant type：Contract research
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新規抗体アンカリング分子の創出
2020.10 - 2023.3
Joint research
Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
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我々が新しく発見したNK細胞subsetの機能解明と養子免疫治療への応用
Grant number：18H04060 2018 - 2021
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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独自に発見した全く新しいphenotypeのNK細胞を用いた養子免疫技術の開発
2018 - 2020
AMED シーズB
Authorship：Coinvestigator(s) Grant type：Contract research
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NK細胞のLicensingと活性に関する研究～臨床応用に向けて
Grant number：18K16119 2018 - 2019
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists
Authorship：Principal investigator Grant type：Scientific research funding
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日本消化器癌発生学会
2018
Grant type：Donation
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全く新しいNK細胞養子免疫技術の研究・実用化開発
2017
上原記念生命科学財団研究奨励金
Authorship：Principal investigator Grant type：Contract research
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Sphere破壊能を指標とした難治性悪性腫瘍に対する薬剤スクリーニングの創成
Grant number：16K15619 2016 - 2018
Grants-in-Aid for Scientific Research Grant-in-Aid for challenging Exploratory Research
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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難治性がんにおけるSelf-niche仮説の提唱と革新的治療の開発
Grant number：16K15620 2016 - 2018
Grants-in-Aid for Scientific Research Grant-in-Aid for challenging Exploratory Research
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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小児神経芽腫自然退縮メカニズムの解明～治療への応用可能性の探究～
Grant number：16K20346 2016 - 2017
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Authorship：Principal investigator Grant type：Scientific research funding
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腹膜播種の成立機序に基づいた革新的HTS技術による創薬推進
2016
創薬等支援技術基盤PF事業
Authorship：Principal investigator Grant type：Contract research
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がん幹細胞化に関与するSphere形成メカニズムを標的とした革新的治療開発
Grant number：15H05792 2015 - 2020
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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腹膜播種細胞が足場とする領域の同定とその標的化による治療技術の開発
2015
創薬等支援技術基盤PF事業
Authorship：Principal investigator Grant type：Contract research
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腹膜播種細胞が足場とするニッシェ様細胞の同定とその標的化による治療技術の開発
Grant number：25293286 2013 - 2016
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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新しい概念に基づく遺伝子操作マウス創出基盤の確立
Grant number：25670176 2013 - 2016
Grants-in-Aid for Scientific Research Grant-in-Aid for challenging Exploratory Research
Authorship：Coinvestigator(s) Grant type：Scientific research funding
Teaching Student Awards
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優秀演題賞
Year and month of award：2024.3
Classification of award-winning students：Postgraduate student Name of award-winning student：袁殊悦