Updated on 2024/06/10

Information

 

写真a

 
YASUDA NORIKO
 
Organization
Faculty of Pharmaceutical Sciences Assistant Professor
Title
Assistant Professor
Tel
0926426337
External link

Degree

  • Doctor of Philosophy (Agricultural Science)

Research Interests・Research Keywords

  • Research theme：Analysis of genomic instability and retrotransposon in cancer progression

    Keyword：Genomic instability, Retrotransposons, LINE-1

    Research period： 2024.5

  • Research theme：Influence of fibroblasts on immune response and its application to cancer therapy

    Keyword：fibroblast, immune response, cancer

    Research period： 2024.5

Papers

  • RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. International journal

    Jun Zhang, Lingfeng Fu, Huaitao Wang, Atsuko Yonemura, Takashi Semba, Noriko Yasuda-Yoshihara, Akiho Nishimura, Takuya Tajiri, Yilin Tong, Tadahito Yasuda, Tomoyuki Uchihara, Masaya Yamazaki, Yuya Okamoto, Juntaro Yamasaki, Osamu Nagano, Hideo Baba, Takatsugu Ishimoto

    Cancer letters   216901 - 216901   2024.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.canlet.2024.216901

  • Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. International journal

    Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, Xichen Hu, Feng Wei, Fumimasa Kitamura, Takahiko Akiyama, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Masaaki Iwatsuki, Yuji Miyamoto, Keisuke Matsusaki, Juntaro Yamasaki, Osamu Nagano, Hideyuki Saya, Shumei Song, Patrick Tan, Hideo Baba, Jaffer A Ajani, Takatsugu Ishimoto

    Cell reports   43 ( 1 )   113613 - 113613   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.celrep.2023.113613

  • Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion

    Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, Akiho Nishimura, Luke Bu, Lingfeng Fu, Feng Wei, Jun Zhang, Yilin Tong, Huaitao Wang, Kazuya Iwamoto, Takaichi Fukuda, Hayato Nakagawa, Koji Taniguchi, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto

    JHEP Reports   5 ( 12 )   100892 - 100892   2023.12

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jhepr.2023.100892

  • <scp>LINE</scp>‐1 hypomethylation, increased retrotransposition and tumor‐specific insertion in upper gastrointestinal cancer

    2023.11

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    Language：Others   Publishing type：Research paper (scientific journal)  

    Abstract

    The long interspersed nuclear element‐1 (LINE‐1) retrotransposons are a major family of mobile genetic elements, comprising approximately 17&#37; of the human genome. The methylation state of LINE‐1 is often used as an indicator of global DNA methylation levels and it regulates the retrotransposition and somatic insertion of the genetic element. We have previously reported the significant relationship between LINE‐1 hypomethylation and poor prognosis in upper gastrointestinal (GI) cancers. However, the causal relationships between LINE‐1 hypomethylation, retrotransposition, and tumor‐specific insertion in upper GI cancers remain unknown. We used bisulfite‐pyrosequencing and quantitative real‐time PCR to verify LINE‐1 methylation and copy number in tissue samples of 101 patients with esophageal and 103 patients with gastric cancer. Furthermore, we analyzed the LINE‐1 retrotransposition profile with an originally developed L1Hs‐seq. In tumor samples, LINE‐1 methylation levels were significantly lower than non‐tumor controls, while LINE‐1 copy numbers were markedly increased. As such, there was a significant inverse correlation between the LINE‐1 methylation level and copy number in tumor tissues, with lower LINE‐1 methylation levels corresponding to higher LINE‐1 copy numbers. Of particular importance is that somatic LINE‐1 insertions were more numerous in tumor than normal tissues. Furthermore, we observed that LINE‐1 was inserted evenly across all chromosomes, and most often within genomic regions associated with tumor‐suppressive genes. LINE‐1 hypomethylation in upper GI cancers is related to increased LINE‐1 retrotransposition and tumor‐specific insertion events, which may collectively contribute to the acquisition of aggressive tumor features through the inactivation of tumor‐suppressive genes.

    DOI： 10.1111/cas.16007

  • 膵癌腫瘍関連線維芽細胞における乳酸代謝の役割についての検討(Investigation of the role of the lactate metabolism in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma)

    山田 晃亮, 北村 文優, 千場 隆, 魏 峰, 永野 修, 西村 朗甫, トン 依霖, 安田 忠仁, 安田 法子, 山崎 淳太郎, 米村 敦子, 馬場 秀夫, 石本 崇胤

    日本癌学会総会記事   82回   565 - 565   2023.9

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    Language：English  

  • Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. International journal

    Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, Huaitao Wang, Takahiko Akiyama, Kazuki Matsumura, Norio Uemura, Rumi Itoyama, Luke Bu, Lingfeng Fu, Xichen Hu, Feng Wei, Kosuke Mima, Katsunori Imai, Hiromitsu Hayashi, Yo-Ichi Yamashita, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto

    JCI insight   8 ( 20 )   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1172/jci.insight.163022

  • Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. International journal

    83 ( 5 )   753 - 770   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    Excess stroma and cancer-associated fibroblasts (CAFs) enhance cancer progression and faciliate immune evasion. Insights into the mechanisms by which the stroma manipulates the immune microenvironment could help improve cancer treatment. Here, we aimed to elucidate potential approaches for stromal reprogramming and improved cancer immunotherapy. Platelet-derived growth factor C (PDGFC) and D expression were significantly associated with a poor prognosis in patients with gastric cancer (GC), and PDGF receptor beta (PDGFRβ) was predominantly expressed in diffuse-type GC stroma. CAFs stimulated with PDGFs exhibited markedly increased expression of CXCL1, CXCL3, CXCL5 and CXCL8, which are involved in polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) recruitment. Fibrotic GC xenograft tumors exhibited increased PMN-MDSC accumulation and decreased lymphocyte infiltration, as well as resistance to anti-PD-1. Single-cell RNA sequencing and spatial transcriptomics revealed that PDGFRα/β blockade reversed the immunosuppressive microenvironment through stromal modification. Finally, combining PDGFRα/β blockade and anti-PD-1 treatment synergistically suppressed the growth of fibrotic tumors. These findings highlight the impact of stromal reprogramming on immune reactivation and the potential for combined immunotherapy for patients with fibrotic cancer.

    DOI： 10.1158/0008-5472.CAN-22-1890

  • A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts. International journal

    Feng Wei, Tomoyuki Uchihara, Atsuko Yonemura, Noriko Yasuda-Yoshihara, Tadahito Yasuda, Takashi Semba, Masahiro Fukuda, Takahiko Akiyama, Fumimasa Kitamura, Luke Bu, Xichen Hu, Lingfeng Fu, Jun Zhang, Ryusho Kariya, Juntaro Yamasaki, Kazuki Aihara, Kohei Yamashita, Osamu Nagano, Seiji Okada, Hideo Baba, Takatsugu Ishimoto

    The FEBS journal   290 ( 10 )   2604 - 2615   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/febs.16712

  • IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment.

    26 ( 2 )   187 - 202   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Remodeling the tumor microenvironment (TME) to benefit cancer cells is crucial for tumor progression. Although diffuse-type gastric cancer (DGC) preferentially interacts with the TME, the precise mechanism of the complicated network remains unknown. This study aimed to investigate the mutual activation mechanism underlying DGC progression. METHODS: Mass cytometry analysis of co-cultured macrophages, noncancerous fibroblasts (NFs), and DGC cells was performed. RNA sequencing was applied to examine gene expression in fibroblasts. DGC cells were treated with cytokines to examine their effect on characteristic changes. The TCGA and Kumamoto University cohorts were used to evaluate the clinical relevance of the in vitro findings. RESULTS: Cohort analysis revealed that DGC patients had a poor prognosis. The fibroblasts and macrophages interacted with DGC cells to form a cell cluster in the invasive front of DGC tissue. The original 3D triple co-culture system determined the promotional effects of nonmalignant cells on DGC invasive growth. We notably identified a mixed-polarized macrophage cell type with M1/M2 cell surface markers in a triple co-culture system. IL-1β from mixed-polarized macrophages induced the conversion of NFs to cancer-associated fibroblast-like (CAF-like) cells, promoting the malignant phenotype of DGC cells by inducing the secretion of IL-6, IL-24, and leukemia inhibitory factor (LIF). Moreover, IL-6 and colony stimulating factor 2 (GM-CSF) cooperated to maintain the stable state of mixed-polarized macrophages. Finally, we found that mixed-polarized macrophages were frequently detected in DGC tissues. CONCLUSION: These findings demonstrated that mixed-polarized macrophages exist as a novel subtype through the reciprocal interaction between DGC cells and nonmalignant cells.

    DOI： 10.1007/s10120-022-01352-3

  • Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression. International journal

    Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi

    JCI insight   7 ( 21 )   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1172/jci.insight.156802

  • ASO Visual Abstract: Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer. International journal

    Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita, Noriko Yasuda-Yoshihara, Taishi Yamane, Chihiro Matsumoto, Kazuto Harada, Kojiro Eto, Junji Kurashige, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba

    Annals of surgical oncology   30 ( 2 )   1253 - 1254   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1245/s10434-022-12555-4

  • Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer. International journal

    Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita, Noriko Yasuda-Yoshihara, Taishi Yamane, Chihiro Matsumoto, Kazuto Harada, Kojiro Eto, Junji Kurashige, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba

    Annals of surgical oncology   30 ( 2 )   1240 - 1252   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1245/s10434-022-12505-0

  • Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer. International journal

    Luke Bu, Atsuko Yonemura, N Yasuda-Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto

    Cancer science   113 ( 10 )   3579 - 3592   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/cas.15495

  • PD-L1 and PD-L2 expression status in relation to chemotherapy in primary and metastatic esophageal squamous cell carcinoma. International journal

    Kazuo Okadome, Yoshifumi Baba, Noriko Yasuda-Yoshihara, Daichi Nomoto, Taisuke Yagi, Tasuku Toihata, Katsuhiro Ogawa, Hiroshi Sawayama, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Yoshihiro Komohara, Hideo Baba

    Cancer science   113 ( 2 )   399 - 410   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/cas.15198

  • Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.

    Lingfeng Fu, Atsuko Yonemura, Noriko Yasuda-Yoshihara, Terumasa Umemoto, Jun Zhang, Tadahito Yasuda, Tomoyuki Uchihara, Takahiko Akiyama, Fumimasa Kitamura, Kohei Yamashita, Yuya Okamoto, Luke Bu, Feng Wei, Xichen Hu, Yang Liu, Jaffer A Ajani, Patrick Tan, Hideo Baba, Takatsugu Ishimoto

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   25 ( 3 )   542 - 557   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10120-022-01283-z

  • Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer. International journal

    Rumi Itoyama, Noriko Yasuda-Yoshihara, Fumimasa Kitamura, Tadahito Yasuda, Luke Bu, Atsuko Yonemura, Tomoyuki Uchihara, Kota Arima, Xichen Hu, Zhang Jun, Yuya Okamoto, Takahiko Akiyama, Kohei Yamashita, Yosuke Nakao, Toshihiko Yusa, Yuki Kitano, Takaaki Higashi, Tatsunori Miyata, Katsunori Imai, Hiromitsu Hayashi, Yo-Ichi Yamashita, Takumi Mikawa, Hiroshi Kondoh, Hideo Baba, Takatsugu Ishimoto

    Cancer letters   523   29 - 42   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.canlet.2021.09.007

  • Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer. International journal

    Kohei Yamashita, Masaaki Iwatsuki, Noriko Yasuda-Yoshihara, Takeshi Morinaga, Yosuke Nakao, Kazuto Harada, Kojiro Eto, Junji Kurashige, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yohei Nagai, Shiro Iwagami, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Jaffer A Ajani, Hideo Baba

    British journal of cancer   124 ( 3 )   595 - 603   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41416-020-01138-3

  • Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination. International journal

    Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, Keisuke Miyake, Ryusho Kariya, Sho Kubota, Takako Yokomizo-Nakano, Noriko Yasuda-Yoshihara, Tomoyuki Uchihara, Rumi Itoyama, Luke Bu, Lingfeng Fu, Kota Arima, Daisuke Izumi, Shiro Iwagami, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hiroto Ohguchi, Seiji Okada, Keisuke Matsusaki, Goro Sashida, Akiko Takahashi, Patrick Tan, Hideo Baba, Takatsugu Ishimoto

    Cell reports   34 ( 8 )   108779 - 108779   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.celrep.2021.108779

  • High ARHGEF2 (GEF-H1) Expression is Associated with Poor Prognosis Via Cell Cycle Regulation in Patients with Pancreatic Cancer. International journal

    Yosuke Nakao, Shigeki Nakagawa, Yo-Ichi Yamashita, Naoki Umezaki, Yuya Okamoto, Yoko Ogata, Noriko Yasuda-Yoshihara, Rumi Itoyama, Toshihiko Yusa, Kohei Yamashita, Tatsunori Miyata, Hirohisa Okabe, Hiromitsu Hayashi, Katsunori Imai, Hideo Baba

    Annals of surgical oncology   28 ( 8 )   4733 - 4743   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1245/s10434-020-09383-9

  • Effective recovery of highly purified CD326(+) tumor cells from lavage fluid of patients treated with a novel cell-free and concentrated ascites reinfusion therapy (KM-CART) Reviewed

    Yukino Kimura, Yui Harada, Noriko Yasuda, Takefumi Ishidao, Seiichi Yusa, Keisuke Matsusaki, Yoshikazu Yonemitsu

    SPRINGERPLUS   4   780   2015.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40064-015-1508-3

  • Molecular Characterization of cDNA Clones Encoding Flavanone 3-Hydroxylase from Dutch Iris (Iris x hollandica) Reviewed

    Noriko Yoshihara, Masako Fukuchii-Mizutani, Hiroaki Okuhara, Yoshikazu Tanaka, Tsutonnu Yabuya

    CYTOLOGIA   77 ( 3 )   359 - 367   2012.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1508/cytologia.77.359

  • Interspecific Hybrids between Iris setosa var. setosa and I. laevigata and Their Relationships to I. setosa var. hondoensis or I. setosa var. nasuensis Reviewed

    Kouichi Inoue, Takeshi Tomita, Noriko Yoshihara, Tsutomu Yabuya

    CYTOLOGIA   73 ( 4 )   401 - 410   2008.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1508/cytologia.73.401

  • Molecular cloning and characterization of O-methyltransferases from the flower buds of Iris hollandica. Reviewed International journal

    Noriko Yoshihara, Masako Fukuchi-Mizutani, Hiroaki Okuhara, Yoshikazu Tanaka, Tsutomu Yabuya

    Journal of plant physiology   165 ( 4 )   415 - 22   2008.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jplph.2006.12.002

  • Characterization of cDNA clones encoding anthocyanin 3-p-coumaroyltransferase from Iris hollandica Reviewed

    Noriko Yoshihara, Teruyuki Imayama, Yuichiro Matsuo, Masako Fukuchi-Mizutani, Yoshikazu Tanaka, Ikuo Ino, Tsutomu Yabuya

    PLANT SCIENCE   171 ( 5 )   632 - 639   2006.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.plantsci.2006.06.005

  • cDNA cloning and characterization of UDP-glucose : anthocyanidin 3-O-glucosyltransferase in Iris hollandica

    N Yoshihara, T Imayama, M Fukuchi-Mizutani, H Okuhara, Y Tanaka, Ino, I, T Yabuya

    PLANT SCIENCE   169 ( 3 )   496 - 501   2005.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.plantsci.2005.04.007

  • Isolation and characterization of a cDNA clone of UDP-glucose: anthocyanin 5-O-glucosyltransferase in Iris hollandica Reviewed

    T Imayama, N Yoshihara, M Fukuchi-Mizutani, Y Tanaka, Ino, I, T Yabuya

    PLANT SCIENCE   167 ( 6 )   1243 - 1248   2004.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.plantsci.2004.06.020

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Presentations

  • ダッチアイリスにおけるアントシアニジン3-グルコシルトランスフェラーゼcDNAクローンの単離と解析

    吉原法子, 今山輝之, 水谷正子, 奥原宏明, 田中良和, 伊野郁男, 藪谷勤

    日本育種学会  2004.3 

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    Language：Japanese  

    Country：Other  

  • ダッチアイリスにおけるカルコン合成酵素cDNAクローンの単離と解析

    濱砂紳也, 松尾勇一朗, 吉原法子, 水谷正子, 田中良和, 藪谷勤

    日本育種学会  2007.9 

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    Language：Japanese  

    Country：Other  

  • ダッチアイリスにおけるアントシアニン生合成酵素cDNAクローンの単離と解析

    吉原法子, 水谷正子, 田中良和, 藪谷勤

    日本育種学会  2007.9 

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    Language：Japanese  

    Country：Other  

  • ダッチアイリスにおけるアントシアニン生合成酵素cDNAクローンの単離と解析

    吉原法子, 水谷正子, 奥原宏明, 田中良和, 藪谷勤

    日本育種学会  2006.9 

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    Language：Japanese  

    Country：Other  

MISC

  • 継代移植法による高度線維化胃癌マウスモデルの作製

    秋山 貴彦, 石本 崇胤, 米村 敦子, 安田 法子, 北村 文優, 安田 忠仁, 山下 晃平, 伊東山 瑠美, 内原 智幸, 吉田 直矢, 馬場 秀夫

    日本外科学会定期学術集会抄録集   2022.4

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    Language：Japanese  

  • スキルス胃癌間質のPDGF/PDGFRシグナルを標的とした腫瘍微小環境リモデリングへの挑戦

    秋山 貴彦, 石本 崇胤, 安田 法子, 米村 敦子, 安田 忠仁, 小岩 麻由, 山下 晃平, 内原 智幸, 岩槻 政晃, 岩上 志朗, 宮本 裕士, 吉田 直矢, 馬場 秀夫

    日本消化器外科学会雑誌   2021.11

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  • 膵癌微小環境における15pgdh欠失は血管新生及び癌進展を促進する

    ブ・ルコ, 付 凌峰, 米村 敦子, 安田 法子, 北村 文優, 秋山 貴彦, 安田 忠仁, 内原 智幸, 馬場 秀夫, 石本 崇胤

    日本癌学会総会記事   2021.9

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  • 胃癌腹膜播種進展におけるCD90陽性間葉系細胞の意義

    米村 敦子, 安田 法子, 秋山 貴彦, 付 凌峰, Bu Luke, 北村 文優, 安田 忠仁, 内原 智幸, 馬場 秀夫, 石本 崇胤

    日本癌学会総会記事   2021.9

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  • 印環細胞型胃癌に特異的な分子による癌進展機構の解明

    付 凌峰, Bu Luke, 米村 敦子, 安田 法子, 秋山 貴彦, 北村 文優, 安田 忠仁, 内原 智幸, 馬場 秀夫, 石本 崇胤

    日本癌学会総会記事   2021.9

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Professional Memberships

  • Jananese Cancer Association

Research Projects

  • ダッチアイリスにおけるアントシアニンとフラボンのコーピグメンテーション機構の解明

    Grant number：19580005  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding