Updated on 2024/08/09

Information

 

写真a

 
MORODOMI YOSUKE
 
Organization
Faculty of Pharmaceutical Sciences Academic Researcher
Title
Academic Researcher
Contact information
メールアドレス
Tel
0926426337

Degree

  • Doctor of Medicine

Papers

  • Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response". International journal

    Julia A Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R Yates 3rd, Taisuke Kanaji, Xiang-Lei Yang

    Cell reports   42 ( 6 )   112632 - 112632   2023.6

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    DOI: 10.1016/j.celrep.2023.112632

  • Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection. International journal

    Yosuke Morodomi, Sachiko Kanaji, Brian M Sullivan, Alessandro Zarpellon, Jennifer N Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel, Zaverio M Ruggeri, Taisuke Kanaji

    Proceedings of the National Academy of Sciences of the United States of America   119 ( 48 )   e2212659119   2022.11

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    DOI: 10.1073/pnas.2212659119

  • Circulating immune cells with megakaryocyte signature in response to COVID-19 mRNA vaccination. International journal

    Taisuke Kanaji, Yosuke Morodomi, Sachiko Kanaji

    Thrombosis research   220   1 - 4   2022.10

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    DOI: 10.1016/j.thromres.2022.10.003

  • Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome. International journal

    Sachiko Kanaji, Wenqian Chen, Yosuke Morodomi, Ryan Shapiro, Taisuke Kanaji, Xiang-Lei Yang

    Trends in biochemical sciences   2022.10

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    DOI: 10.1016/j.tibs.2022.09.011

  • The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse. International journal

    107 ( 9 )   2133 - 2143   2022.9

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    Type 2B von Willebrand disease (VWD) is caused by gain-of-function mutations in von Willebrand factor (VWF). Increased VWF affinity for GPIba results in loss of high molecular weight multimers and enhanced platelet clearance, both contributing to the bleeding phenotype. Severity of the symptoms vary among type 2B VWD patients, with some developing thrombocytopenia only under stress conditions. Efforts have been made to study underlying pathophysiology for platelet abnormalities, but animal studies have been limited because of species specificity in the VWF-GPIba interaction. Here, we generated a severe form of type 2B VWD (p.V1316M) knockin mice in the context of human VWF exon 28 (encoding A1 and A2 domains) and crossed them with human GPIba transgenic strain. Heterozygous mutant mice recapitulated the phenotype of type 2B VWD in autosomal dominant manner and presented severe macrothrombocytopenia. Of note, platelets remaining in the circulation had extracytoplasmic GPIba shed-off from the cell surface. Reciprocal bone marrow transplantation determined mutant VWF produced from endothelial cells as the major cause of the platelet phenotype in type 2B VWD mice. Moreover, altered megakaryocyte maturation in the bone marrow and enhanced extramedullary megakaryopoiesis in the spleen were observed. Interestingly, injection of anti-VWF A1 blocking antibody (NMC-4) not only ameliorated platelet count and GPIba expression, but also reversed MK ploidy shift. In conclusion, we present a type 2B VWD mouse model with humanized VWF-GPIba interaction which demonstrated direct influence of aberrant VWF-GPIba binding on megakaryocytes.

    DOI: 10.3324/haematol.2021.280561

  • Detection of anti-GPIbα autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination. International journal

    209   80 - 83   2022.1

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    DOI: 10.1016/j.thromres.2021.11.030

  • Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. International journal

    Josh Sun, Satoshi Uchiyama, Joshua Olson, Yosuke Morodomi, Ingrid Cornax, Nao Ando, Yohei Kohno, May M T Kyaw, Bernice Aguilar, Nina M Haste, Sachiko Kanaji, Taisuke Kanaji, Warren E Rose, George Sakoulas, Jamey D Marth, Victor Nizet

    Science translational medicine   13 ( 586 )   2021.3

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    DOI: 10.1126/scitranslmed.abd6737

  • Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet α-granules: Potential role in monocyte activation. International journal

    4 ( 7 )   1167 - 1177   2020.10

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    BACKGROUND: Tyrosyl-tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions. Although database results indicate extremely low levels of YRS mRNA in platelets, YRS protein is abundantly present. The source of YRS in platelets, as well as the physiological role of platelet-stored YRS, remains largely unknown. OBJECTIVES: To clarify how YRS accumulates in platelets and determine the potential role of platelet-stored YRS. METHODS: Recombinant YRS proteins with epitope tags were prepared and tested in vitro for proteolytic cleavage in human plasma. Fluorescent-labeled YRS was examined for uptake by platelets, as demonstrated by western blotting and confocal microscopy analysis. Using RAW-Dual reporter cells, Toll-like receptor and type I interferon activation pathways were analyzed after treatment with YRS. RESULTS: Full-length YRS was cleaved by both elastase and matrix metalloproteinases in the plasma. The cleaved, N-terminal YRS fragment corresponds to the endogenous YRS detected in platelet lysate by western blotting. Both full-length and cleaved forms of YRS were taken up by platelets in vitro and stored in the α-granules. The N-terminal YRS fragment generated by proteolytic cleavage had monocyte activation comparable to that of the constitutive-active mutant YRS (YRSY341A) previously reported. CONCLUSION: Platelets take up both full-length YRS and the active form of cleaved YRS fragment from the plasma. The cleaved, N-terminal YRS fragment stored in α-granules may have potential to activate monocytes.

    DOI: 10.1002/rth2.12429

  • LINE-1 Hypomethylation Is Associated With Malignant Traits and Cell Proliferation in Lung Adenocarcinoma. International journal

    Hirokazu Kitahara, Tatsuro Okamoto, Shinichiro Shimamatsu, Mikihiro Kohno, Yosuke Morodomi, Tetsuzo Tagawa, Hiroyuki Kitao, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara, Masaki Mori

    Anticancer research   40 ( 10 )   5659 - 5666   2020.10

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    DOI: 10.21873/anticanres.14579

  • Mechanisms of anti-GPIbα antibody-induced thrombocytopenia in mice. International journal

    135 ( 25 )   2292 - 2301   2020.6

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    Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysiology of ITP has yet to be fully delineated. In this study, we tested 2 mouse models of immune-mediated thrombocytopenia using the rat anti-mouse GPIbα monoclonal antibody 5A7, generated in our laboratory. After a single IV administration of high-dose (2 mg/kg) 5A7, opsonized platelets were rapidly cleared from the circulation into the spleen and liver; this was associated with rapid upregulation of thrombopoietin (TPO) messenger RNA. In contrast, subcutaneous administration of low-dose 5A7 (0.08-0.16 mg/kg) every 3 days gradually lowered the platelet count; in this case, opsonized platelets were observed only in the spleen, and TPO levels remained unaltered. Interestingly, in both models, the 5A7 antibody was found on the surface of, as well as internalized to, bone marrow megakaryocytes. Consequently, platelets generated in the chronic phase of repeated subcutaneous 5A7 administration model showed reduced GPIbα membrane expression on their surface. Our findings indicate that evaluation of platelet surface GPIbα relative to platelet size may be a useful marker to support the diagnosis of anti-GPIbα antibody-induced ITP.

    DOI: 10.1182/blood.2019003770

  • Modified application of Kawamoto's film method for super-resolution imaging of megakaryocytes in undecalcified bone marrow. International journal

    Yosuke Morodomi, Sachiko Kanaji, Eric Won, Tadafumi Kawamoto, Taisuke Kanaji

    Research and practice in thrombosis and haemostasis   4 ( 1 )   86 - 91   2020.1

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    DOI: 10.1002/rth2.12276

  • TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding. International journal

    Tine Wyseure, Tingyi Yang, Jenny Y Zhou, Esther J Cooke, Bettina Wanko, Merissa Olmer, Ruchi Agashe, Yosuke Morodomi, Niels Behrendt, Martin Lotz, John Morser, Annette von Drygalski, Laurent O Mosnier

    JCI insight   4 ( 19 )   2019.10

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    DOI: 10.1172/jci.insight.128379

  • miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth In Vivo. International journal

    Takaki Akamine, Yosuke Morodomi, Yui Harada, Koji Teraishi, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshihiko Maehara, Yoshikazu Yonemitsu

    Anticancer research   38 ( 10 )   5693 - 5701   2018.10

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    DOI: 10.21873/anticanres.12906

  • Humanized GPIbα-von Willebrand factor interaction in the mouse. International journal

    2 ( 19 )   2522 - 2532   2018.10

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    The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacologic inhibitors have been hindered by the lack of animal models because of the species specificity of the interaction. To address this problem, we generated a knockin mouse with Vwf exon 28-encoding domains A1 and A2 replaced by the human homolog (VWFh28). VWFh28 mice (M1HA) were crossbred with a transgenic mouse strain expressing human GPIbα on platelets (mGPIbαnull;hGPIbαTg; H1MA) to generate a new strain (H1HA) with humanized GPIbα-VWFA1 binding. Plasma VWF levels in the latter 3 strains were similar to those of wild-type mice (M1MA). Compared with the strains that had homospecific GPIbα-VWF pairing (M1MA and H1HA), M1HA mice of those with heterospecific pairing had a markedly greater prolongation of tail bleeding time and attenuation of thrombogenesis after injury to the carotid artery than H1MA mice. Measurements of GPIbα-VWFA1 binding affinity by surface plasmon resonance agreed with the extent of observed functional defects. Ristocetin-induced platelet aggregation was similar in H1HA mouse and human platelet-rich plasma, and it was comparably inhibited by monoclonal antibody NMC-4, which is known to block human GPIbα-VWFA1 binding, which also inhibited FeCl3-induced mouse carotid artery thrombosis. Thus, the H1HA mouse strain is a fully humanized model of platelet GPIbα-VWFA1 binding that provides mechanistic and pharmacologic information relevant to human hemostatic and thrombotic disorders.

    DOI: 10.1182/bloodadvances.2018023507

  • Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. International journal

    Taisuke Kanaji, My-Nuong Vo, Sachiko Kanaji, Alessandro Zarpellon, Ryan Shapiro, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Rajesh Belani, Minh-Ha Do, Xiang-Lei Yang, Zaverio M Ruggeri, Paul Schimmel

    Proceedings of the National Academy of Sciences of the United States of America   115 ( 35 )   E8228-E8235   2018.8

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    DOI: 10.1073/pnas.1807000115

  • Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients. International journal

    Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara

    Cancer science   109 ( 1 )   154 - 165   2018.1

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    DOI: 10.1111/cas.13422

  • Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication. International journal

    Ryota Nakanishi, Hiroyuki Kitao, Mamoru Kiniwa, Yosuke Morodomi, Makoto Iimori, Junji Kurashige, Masahiko Sugiyama, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

    Scientific reports   7 ( 1 )   16969 - 16969   2017.12

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    DOI: 10.1038/s41598-017-17282-5

  • Reply to "EGFR Mutation in Patients with Lung Adenosquamous Cell Carcinoma". International journal

    Yosuke Morodomi, Tatsuro Okamoto, Yoshihiko Maehara

    Annals of surgical oncology   24 ( Suppl 3 )   676 - 676   2017.12

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    DOI: 10.1245/s10434-017-6181-z

  • Clinical Significance of DNA Damage Response Factors and Chromosomal Instability in Primary Lung Adenocarcinoma. International journal

    Tatsuro Okamoto, Mikihiro Kohno, Kensaku Ito, Kazuki Takada, Masakazu Katsura, Yosuke Morodomi, Gouji Toyokawa, Fumihiro Shoji, Yoshihiko Maehara

    Anticancer research   37 ( 4 )   1729 - 1735   2017.4

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  • Underlying Problems in Surgical Treatment of cT1-2N1 Non-Small Cell Lung Cancer. International journal

    Tatsuro Okamoto, Tetsuzo Tagawa, Yosuke Morodomi, Shinichiro Shimamatsu, Hirokazu Kitahara, Yoshihiko Maehara

    The Thoracic and cardiovascular surgeon   65 ( 2 )   130 - 135   2017.3

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    DOI: 10.1055/s-0035-1558648

  • Clinical Evaluation and Outcomes of Digital Chest Drainage after Lung Resection.

    Fumihiro Shoji, Shinkichi Takamori, Takaki Akamine, Gouji Toyokawa, Yosuke Morodomi, Tatsuro Okamoto, Yoshihiko Maehara

    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia   22 ( 6 )   354 - 358   2016.12

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    DOI: 10.5761/atcs.oa.16-00179

  • Prognostic Significance of Expression of the Epithelial-Mesenchymal Transition-Related Factor Brachyury in Intrathoracic Lymphatic Spread of Non-Small Cell Lung Cancer. International journal

    Shinichiro Shimamatsu, Tatsuro Okamoto, Akira Haro, Hirokazu Kitahara, Mikihiro Kohno, Yosuke Morodomi, Tetsuzo Tagawa, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    Annals of surgical oncology   23 ( Suppl 5 )   1012 - 1020   2016.12

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  • A novel method of using bioabsorbable materials for the surgical repair of flail chest. International journal

    Yosuke Morodomi, Tatsuro Okamoto, Tetsuzo Tagawa, Fumihiro Shoji, Masakazu Katsura, Takatoshi Fujishita, Tetsuhiro Fujiyoshi, Tomohiko Akahoshi, Mitsuhiro Yasuda, Yoshihiko Maehara

    The journal of trauma and acute care surgery   81 ( 5 )   984 - 987   2016.11

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  • Clinical implications of sarcopenia in patients undergoing complete resection for early non-small cell lung cancer. International journal

    Yuzo Suzuki, Tatsuro Okamoto, Takatoshi Fujishita, Masakazu Katsura, Takaki Akamine, Shinkichi Takamori, Yosuke Morodomi, Tetsuzo Tagawa, Fumihiro Shoji, Yoshihiko Maehara

    Lung cancer (Amsterdam, Netherlands)   101   92 - 97   2016.11

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    DOI: 10.1016/j.lungcan.2016.08.007

  • Clinical Significance of PD-L1 Protein Expression in Surgically Resected Primary Lung Adenocarcinoma. International journal

    Kazuki Takada, Tatsuro Okamoto, Fumihiro Shoji, Mototsugu Shimokawa, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Yuzo Suzuki, Takatoshi Fujishita, Gouji Toyokawa, Yosuke Morodomi, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   11 ( 11 )   1879 - 1890   2016.11

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    DOI: 10.1016/j.jtho.2016.06.006

  • Predictive impact for postoperative recurrence using the preoperative prognostic nutritional index in pathological stage I non-small cell lung cancer. International journal

    Fumihiro Shoji, Yosuke Morodomi, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Tatsuro Okamoto, Yoshihiko Maehara

    Lung cancer (Amsterdam, Netherlands)   98   15 - 21   2016.8

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    DOI: 10.1016/j.lungcan.2016.05.010

  • Case of a Cardiopulmonary Arrest Due to Postoperative Subglottic Stenosis Developed on the Second Day after Lung Surgery.

    Tomonari Shimagaki, Tatsuro Okamoto, Yosuke Morodomi, Fumihiro Shoji, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Kengo Hayamizu, Kentaro Tokuda, Mitsuhiro Yasuda, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   107 ( 7 )   136 - 40   2016.7

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  • Nanomedicines Eradicating Cancer Stem-like Cells in Vivo by pH-Triggered Intracellular Cooperative Action of Loaded Drugs. International journal

    Hiroaki Kinoh, Yutaka Miura, Tsukasa Chida, Xueying Liu, Kazue Mizuno, Shigeto Fukushima, Yosuke Morodomi, Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka

    ACS nano   10 ( 6 )   5643 - 55   2016.6

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    DOI: 10.1021/acsnano.6b00900

  • Prognostic Impact of EGFR Driver Mutations on Postoperative Disease Recurrence in Lung Adenocarcinoma. International journal

    Tatsuro Okamoto, Hirokazu Kitahara, Shinichiro Shimamatsu, Masakazu Katsura, Kazuki Takada, Takatoshi Fujishita, Yuzo Suzuki, Yosuke Morodomi, Tetsuzo Tagawa, Yoshihiko Maehara

    Anticancer research   36 ( 6 )   3057 - 63   2016.6

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  • The antibodies against 5-bromo-2'-deoxyuridine specifically recognize trifluridine incorporated into DNA. International journal

    Hiroyuki Kitao, Yosuke Morodomi, Shinichiro Niimi, Mamoru Kiniwa, Kazuhiko Shigeno, Kazuaki Matsuoka, Yuki Kataoka, Makoto Iimori, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

    Scientific reports   6   25286 - 25286   2016.5

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    DOI: 10.1038/srep25286

  • Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation. International journal

    Yuta Kasagi, Yui Harada, Yosuke Morodomi, Toshiki Iwai, Satoru Saito, Kumi Yoshida, Eiji Oki, Hiroshi Saeki, Kippei Ohgaki, Masahiko Sugiyama, Mitsuho Onimaru, Yoshihiko Maehara, Yoshikazu Yonemitsu

    Cancer research   76 ( 2 )   347 - 57   2016.1

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    DOI: 10.1158/0008-5472.CAN-15-1563

  • PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer. International journal

    11 ( 1 )   62 - 71   2016.1

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    OBJECTIVES: The programmed death ligand 1(PD-L1)/programmed cell death protein 1 (PD-1) pathway is one of the most important checkpoint pathways for mediating tumor-induced immune suppression through T-cell exhaustion. Recently, targeted therapies using monoclonal antibodies against components of this pathway have been shown to reduce tumor burden in patients with non-small cell lung cancer (NSCLC). However, the prognostic significance of PD-L1 expression is controversial and the precise mechanisms of PD-L1 gene activation in lung cancer have yet to be clarified. METHODS: We investigated copy number alterations (CNAs) in the PD-L1 gene by real-time PCR in 94 surgically resected lung cancer samples to find possible associations between PD-L1 CNA and lung cancer biology. Janus kinase 2 gene (JAK2) CNA and its influence on the PD-L1/PD-1 pathway were also assessed. RESULTS: Five samples were shown to have PD-L1 gene amplification, whereas 89 samples did not. The patients with PD-L1 amplification had worse prognoses than did those without PD-L1 amplification. Genetic amplification of the PD-L1 gene was correlated with JAK2 gene amplification. The lung cancer cell line HCC4006 was found to harbor both JAK2 and PD-L1 amplification. Flow cytometry analyses revealed the level of PD-L1 protein expression to be higher in HCC4006 cells than in other NSCLC cell lines. Expression of the PD-L1 protein was significantly reduced by the JAK2 inhibitor TG-101348 and the signal transducer and activator of transcription 3 (STAT-3) inhibitor BP-1-102, but not by the STAT1 inhibitor fludarabine. CONCLUSIONS: Our data suggest that expression of PD-L1 protein is upregulated by the simultaneous amplification of the PD-L1 and JAK2 genes through JAK-STAT signaling in NCSLC.

    DOI: 10.1016/j.jtho.2015.09.010

  • Clinical role of a new prognostic score using platelet-to-lymphocyte ratio in patients with malignant pleural mesothelioma undergoing extrapleural pneumonectomy. International journal

    Tetsuzo Tagawa, Masaki Anraku, Yosuke Morodomi, Tomoyoshi Takenaka, Tatsuro Okamoto, Mitsuhiro Takenoyama, Yukito Ichinose, Yoshihiko Maehara, B C John Cho, Ronald Feld, Ming-Sound Tsao, Natasha Leighl, Andrea Bezjak, Shaf Keshavjee, Marc de Perrot

    Journal of thoracic disease   7 ( 11 )   1898 - 906   2015.11

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    DOI: 10.3978/j.issn.2072-1439.2015.11.15

  • Clinical Significance of Detecting Somatic Gene Mutations in Surgically Resected Adenosquamous Cell Carcinoma of the Lung in Japanese Patients. International journal

    Yosuke Morodomi, Tatsuro Okamoto, Mitsuhiro Takenoyama, Kazuki Takada, Masakazu Katsura, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Tetsuzo Tagawa, Shinji Okano, Kenichi Taguchi, Yukito Ichinose, Yoshihiko Maehara

    Annals of surgical oncology   22 ( 8 )   2593 - 8   2015.8

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    DOI: 10.1245/s10434-014-4218-0

  • Liver transplantation followed by pulmonary resection complicated with end-stage liver cirrhosis: a case report. International journal

    Daisuke Taniguchi, Norifumi Harimoto, Kazuki Takeishi, Shinji Itoh, Yoichi Yamashita, Toru Ikegami, Tomoharu Yoshizumi, Hirofumi Kawanaka, Ken Shirabe, Yosuke Morodomi, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshihiko Maehara

    Anticancer research   35 ( 6 )   3411 - 4   2015.6

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  • 下部消化管 腹膜播種の薬剤耐性出現の分子メカニズムと新規治療戦略

    笠木 勇太, 原田 結, 諸富 洋介, 堤 亮介, 西村 章, 中司 悠, 工藤 健介, 堤 智崇, 田尻 裕匡, 由茅 隆文, 田中 仁寛, 財津 瑛子, 津田 康雄, 中島 雄一郎, 安藤 幸滋, 今村 裕, 大垣 吉平, 佐伯 浩司, 沖 英次, 米満 吉和, 前原 喜彦

    日本外科学会定期学術集会抄録集   115回   YIA - 2   2015.4

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  • Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer. International journal

    Yosuke Morodomi, Tatsuro Okamoto, Mikihiro Kohno, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Tsukihisa Yoshida, Tetsuzo Tagawa, Shinji Okano, Yoshihiko Maehara

    Anticancer research   35 ( 3 )   1791 - 6   2015.3

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  • Impact of the epidermal growth factor receptor mutation status on the post-recurrence survival of patients with surgically resected non-small-cell lung cancer. International journal

    Tomoyoshi Takenaka, Mitsuhiro Takenoyama, Masafumi Yamaguchi, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Gouji Toyokawa, Tsukihisa Yoshida, Yoshimasa Shiraishi, Yosuke Morodomi, Fumihiko Hirai, Kenichi Taguchi, Mototsugu Shimokawa, Takashi Seto, Yukito Ichinose

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   47 ( 3 )   550 - 5   2015.3

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    DOI: 10.1093/ejcts/ezu227

  • 肺腺癌の発癌・進展におけるProgrammed Death of Ligand 1発現の意義 Reviewed

    高田 和樹, 岡野 慎士, 寺石 紘司, 桂 正和, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 諸富 洋介, 田川 哲三, 岡本 龍郎, 小田 義直, 前原 喜彦

    肺癌   54 ( 5 )   525 - 525   2014.10

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  • 非小細胞肺癌におけるPD-L1およびJAK2遺伝子増幅とPD-L1発現への関与 Reviewed

    岡本 龍郎, 池田 誠一, 岡野 慎士, 梅本 雄一郎, 田川 哲三, 諸富 洋介, 島松 晋一郎, 北原 大和, 鈴木 雄三, 藤下 卓才, 桂 正和, 高田 和樹, 前原 喜彦

    肺癌   54 ( 5 )   440 - 440   2014.10

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  • Gemcitabine and vinorelbine as second-line or beyond treatment in patients with malignant pleural mesothelioma pretreated with platinum plus pemetrexed chemotherapy.

    Gouji Toyokawa, Mitsuhiro Takenoyama, Fumihiko Hirai, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Yosuke Morodomi, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mototsugu Shimokawa, Takashi Seto, Yukito Ichinose

    International journal of clinical oncology   19 ( 4 )   601 - 6   2014.8

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    DOI: 10.1007/s10147-013-0619-5

  • The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer--differences between adenocarcinoma and squamous cell carcinoma. International journal

    Tatsuro Okamoto, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Yosuke Morodomi, Daigo Kawano, Yoshihiko Maehara

    Lung cancer (Amsterdam, Netherlands)   85 ( 2 )   125 - 30   2014.8

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    DOI: 10.1016/j.lungcan.2014.06.006

  • Non-small cell lung cancer patients with EML4-ALK fusion gene are insensitive to cytotoxic chemotherapy. International journal

    Yosuke Morodomi, Mitsuhiro Takenoyama, Eiko Inamasu, Ryo Toyozawa, Miyako Kojo, Gouji Toyokawa, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Kenichi Taguchi, Takashi Seto, Kenji Sugio, Yukito Ichinose

    Anticancer research   34 ( 7 )   3825 - 30   2014.7

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  • Application of continuous negative pressure irrigation and negative pressure fixation to treat a bronchopleural fistula with thoracic empyema. International journal

    Yosuke Morodomi, Mitsuhiro Takenoyama, Masafumi Yamaguchi, Eiko Inamasu, Tsukihisa Yoshida, Daigo Kawano, Tatsuro Okamoto, Yojiro Inoue, Yoshihiko Maehara, Yukito Ichinose

    Journal of the American College of Surgeons   218 ( 5 )   e87-90   2014.5

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    DOI: 10.1016/j.jamcollsurg.2013.12.053

  • Successful resection of a giant mediastinal non-seminomatous germ cell tumor showing fluorodeoxyglucose accumulation after neoadjuvant chemotherapy: report of a case.

    Kazuki Takada, Yosuke Morodomi, Tatsuro Okamoto, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Daigo Kawano, Noriko Hidaka, Yoichi Nakanishi, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   105 ( 5 )   117 - 23   2014.5

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  • A rare case of a bronchial anomaly running in the hilar region from the right lower lobe to the middle lobe.

    Takatoshi Fujishita, Tatsuro Okamoto, Yuzo Suzuki, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Yosuke Morodomi, Daigo Kawano, Yoshio Matsuo, Hiroshi Honda, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   105 ( 4 )   100 - 4   2014.4

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  • [Case of pulmonary inflammatory pseudotumor with cysts].

    Masakazu Katsura, Hirokazu Kitahara, Yosuke Morodomi, Daigo Kawano, Takaomi Koga, Toshiya Furuta, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   105 ( 3 )   74 - 8   2014.3

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  • 肺腺癌の発癌・進展におけるProgrammed Death of Ligand 1(PD-L1)発現意義の免疫病理学的検討 Reviewed

    岡本 龍郎, 池田 誠一, 梅本 雄一郎, 岡野 慎士, 川野 大悟, 諸富 洋介, 河野 幹寛, 島松 晋一郎, 北原 大和, 鈴木 雄三, 藤下 卓才, 小田 義直, 前原 喜彦

    日本外科学会雑誌   115 ( 臨増2 )   436 - 436   2014.3

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  • 肺腺癌の発癌・進展におけるProgrammed Death of Ligand 1(PD-L1)発現意義の免疫病理学的検討 Reviewed

    岡野 慎士, 岡本 龍郎, 池田 誠一, 梅本 雄一郎, 川野 大悟, 諸富 洋介, 河野 幹寛, 島松 晋一郎, 北原 大和, 鈴木 雄三, 藤下 卓才, 小田 義直, 居石 克夫, 前原 喜彦

    日本病理学会会誌   103 ( 1 )   203 - 203   2014.3

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  • Dramatic response to crizotinib in an ALK-positive adenocarcinoma patient with disseminated intravascular coagulation. International journal

    Gouji Toyokawa, Mitsuhiro Takenoyama, Sawori Watanabe, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Yoshimasa Shiraishi, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Kenichi Taguchi, Takashi Seto, Yukito Ichinose

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   8 ( 11 )   e96-8   2013.11

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    DOI: 10.1097/JTO.0b013e3182a008ed

  • Amrubicin as second-line and beyond treatment for platinum-refractory advanced thymic carcinoma. International journal

    Fumihiko Hirai, Takashi Seto, Takeharu Yamanaka, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Gouji Toyokawa, Yosuke Morodomi, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Yukito Ichinose

    Japanese journal of clinical oncology   43 ( 10 )   1018 - 22   2013.10

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    DOI: 10.1093/jjco/hyt106

  • [Case of adenocarcinoma in situ accompanied by an intrapulmonary lymph node with a sarcoid-like reaction].

    Daigo Kawano, Tatsuro Okamoto, Yosuke Morodomi, Mikihiro Kono, Shinichiro Shimamatsu, Hirokazu Kitahara, Junji Kawasaki, Mitsuhiro Miyazaki, Motoyuki Yamagata, Takashi Sonoda

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 10 )   394 - 6   2013.10

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  • An extremely rare case of small-cell lung cancer harboring variant 2 of the EML4-ALK fusion gene. International journal

    Gouji Toyokawa, Mitsuhiro Takenoyama, Kenichi Taguchi, Ryo Toyozawa, Eiko Inamasu, Miyako Kojo, Yoshimasa Shiraishi, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Mototsugu Shimokawa, Yukito Ichinose

    Lung cancer (Amsterdam, Netherlands)   81 ( 3 )   487 - 490   2013.9

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    DOI: 10.1016/j.lungcan.2013.05.022

  • The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene. International journal

    Gouji Toyokawa, Mitsuhiro Takenoyama, Kenichi Taguchi, Katsumi Arakaki, Eiko Inamasu, Ryo Toyozawa, Miyako Kojo, Yoshimasa Shiraishi, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Alvaro Leone, Paolo Graziano, Yukito Ichinose

    Lung cancer (Amsterdam, Netherlands)   81 ( 3 )   491 - 494   2013.9

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    DOI: 10.1016/j.lungcan.2013.06.013

  • Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood. International journal

    Satoru Saito, Yui Harada, Yosuke Morodomi, Mitsuho Onimaru, Kumi Yoshida, Ryoichi Kyuragi, Hisahiro Matsubara, Yoshikazu Yonemitsu

    Human gene therapy methods   24 ( 4 )   241 - 52   2013.8

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    DOI: 10.1089/hgtb.2012.183

  • Recurrence of thymic neuroendocrine carcinoma 24 years after total excision: A case report. International journal

    Gouji Toyokawa, Kenichi Taguchi, Miyako Kojo, Ryo Toyozawa, Eiko Inamasu, Yosuke Morodomi, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Mitsuhiro Takenoyama, Yukito Ichinose

    Oncology letters   6 ( 1 )   147 - 149   2013.7

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  • First case of combined small-cell lung cancer with adenocarcinoma harboring EML4-ALK fusion and an exon 19 EGFR mutation in each histological component. International journal

    Gouji Toyokawa, Kenichi Taguchi, Taro Ohba, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Mitsuhiro Takenoyama, Kenji Sugio, Yukito Ichinose

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   7 ( 12 )   e39-e41   2012.12

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    DOI: 10.1097/JTO.0b013e3182762bcb

  • Prediction of true-negative lymph node metastasis in clinical IA non-small cell lung cancer by measuring standardized uptake values on positron emission tomography.

    Tomoyoshi Takenaka, Tokujiro Yano, Yosuke Morodomi, Kensaku Ito, Naoko Miura, Daigo Kawano, Fumihiro Shoji, Shingo Baba, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

    Surgery today   42 ( 10 )   934 - 9   2012.10

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    DOI: 10.1007/s00595-012-0277-7

  • BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression. International journal

    Yosuke Morodomi, Tokujiro Yano, Hiroaki Kinoh, Yui Harada, Satoru Saito, Ryoichi Kyuragi, Kumi Yoshida, Mitsuho Onimaru, Fumihiro Shoji, Tsukihisa Yoshida, Kensaku Ito, Yasunori Shikada, Riichiroh Maruyama, Mamoru Hasegawa, Yoshihiko Maehara, Yoshikazu Yonemitsu

    Molecular therapy : the journal of the American Society of Gene Therapy   20 ( 4 )   769 - 77   2012.4

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    DOI: 10.1038/mt.2011.305

  • Serum antioxidant capacity and oxidative injury to pulmonary DNA in never-smokers with primary lung cancer. International journal

    Kensaku Ito, Tokujiro Yano, Yosuke Morodomi, Tsukihisa Yoshida, Mikihiro Kohno, Akira Haro, Yasunori Shikada, Tatsuro Okamoto, Riichiroh Maruyama, Yoshihiko Maehara

    Anticancer research   32 ( 3 )   1063 - 7   2012.3

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  • Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump. International journal

    Fumihiro Shoji, Tokujiro Yano, Naoko Miura, Yosuke Morodomi, Tsukihisa Yoshida, Mitsuho Onimaru, Yoshihiko Maehara

    Interactive cardiovascular and thoracic surgery   13 ( 3 )   271 - 5   2011.9

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    DOI: 10.1510/icvts.2011.274480

  • Assessing a clinical pathway to improve the quality of care in pulmonary resections.

    Fumihiro Shoji, Tokujiro Yano, Akira Haro, Tsukihisa Yoshida, Kensaku Ito, Yosuke Morodomi, Yoshifumi Wakata, Yoshihiko Maehara

    Surgery today   41 ( 6 )   787 - 90   2011.6

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    DOI: 10.1007/s00595-010-4483-x

  • The influence of intracellular epidermal growth factor receptor (EGFR) signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary adenocarcinoma.

    Daigo Kawano, Tokujiro Yano, Fumihiro Shoji, Kensaku Ito, Yosuke Morodomi, Akira Haro, Naoko Miura, Tomoyoshi Takenaka, Ichiro Yoshino, Yoshihiko Maehara

    Surgery today   41 ( 6 )   818 - 23   2011.6

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    DOI: 10.1007/s00595-011-4514-2

  • Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites. International journal

    Masahiko Sugiyama, Yoshihiro Kakeji, Shunichi Tsujitani, Yui Harada, Mitsuho Onimaru, Kumi Yoshida, Sakura Tanaka, Yasunori Emi, Masaru Morita, Yosuke Morodomi, Mamoru Hasegawa, Yoshihiko Maehara, Yoshikazu Yonemitsu

    Molecular cancer therapeutics   10 ( 3 )   540 - 9   2011.3

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    DOI: 10.1158/1535-7163.MCT-10-0479

  • Effectiveness of erlotinib against recurrent pulmonary adenocarcinoma unresponsive to gefitinib: report of a case.

    Fumihiro Shoji, Daigo Kawano, Kensaku Ito, Yosuke Morodomi, Tokujiro Yano, Yoshihiko Maehara

    Surgery today   41 ( 2 )   255 - 7   2011.2

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    DOI: 10.1007/s00595-009-4259-3

  • Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer. International journal

    Tokujiro Yano, Akira Haro, Tsukihisa Yoshida, Yosuke Morodomi, Kensaku Ito, Yasunori Shikada, Fumihiro Shoji, Riichiroh Maruyama, Yoshihiko Maehara

    Journal of surgical oncology   102 ( 7 )   852 - 5   2010.12

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    DOI: 10.1002/jso.21750

  • Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene. International journal

    18 ( 10 )   1778 - 86   2010.10

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    Glioblastoma multiforme (GM), the most frequent primary malignant brain tumor, is highly invasive due to the expression of proteases, including urokinase-type plasminogen activator (uPA). Here, we show the potential of our new and powerful recombinant Sendai virus (rSeV) showing uPA-specific cell-to-cell fusion activity [rSeV/dMFct14 (uPA2), named "BioKnife"] for GM treatment, an effect that was synergistically enhanced by arming BioKnife with the interferon-β (IFN-β) gene. BioKnife killed human GM cell lines efficiently in a uPA-dependent fashion, and this killing was prevented by PA inhibitor-1. Rat gliosarcoma 9L cells expressing both uPA and its functional receptor uPAR (9L-L/R) exhibited high uPA activity on the cellular surface and were highly susceptible to BioKnife. Although parent 9L cells (9L-P) were resistant to BioKnife and to BioKnife expressing IFN-β (BioKnife-IFNβ), cell-cell fusion of 9L-L/R strongly facilitated the expression of IFN-β, and in turn, IFN-β significantly accelerated the fusion activity of BioKnife. A similar synergy was seen in a rat orthotopic brain GM model with 9L-L/R in vivo; therefore, these results suggest that BioKnife-IFNβ may have significant potential to improve the survival of GM patients in a clinical setting.

    DOI: 10.1038/mt.2010.138

  • Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor. International journal

    Akira Haro, Tokujiro Yano, Tsukihisa Yoshida, Kensaku Ito, Yosuke Morodomi, Fumihiro Shoji, Torahiko Nakashima, Yoshihiko Maehara

    Interactive cardiovascular and thoracic surgery   10 ( 5 )   700 - 3   2010.5

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    DOI: 10.1510/icvts.2009.219766

  • Prognostic significance of intratumoral blood vessel invasion in pathologic stage IA non-small cell lung cancer. International journal

    Fumihiro Shoji, Akira Haro, Tsukihisa Yoshida, Kensaku Ito, Yosuke Morodomi, Tokujiro Yano, Yoshihiko Maehara

    The Annals of thoracic surgery   89 ( 3 )   864 - 9   2010.3

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    DOI: 10.1016/j.athoracsur.2009.09.047

  • Synovial sarcoma of the chest wall.

    Daigo Kawano, Ichiro Yoshino, Fumihiro Shoji, Yosuke Morodomi, Tokujiro Yano, Yoshihiko Maehara

    General thoracic and cardiovascular surgery   58 ( 2 )   95 - 7   2010.2

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    DOI: 10.1007/s11748-009-0480-7

  • Verification of the newly proposed T category (seventh edition of the tumor, node, and metastasis classification) from a clinicopathological viewpoint in non-small cell lung cancer-special reference to tumor size. International journal

    Tokujiro Yano, Yosuke Morodomi, Kensaku Ito, Tsukihisa Yoshida, Akira Haro, Fumihiro Shoji, Takaomi Koga, Yoshihiko Maehara

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   5 ( 1 )   45 - 8   2010.1

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    DOI: 10.1097/JTO.0b013e3181c0996c

  • Clinicopathological significance of Sip1-associated epithelial mesenchymal transition in non-small cell lung cancer progression. International journal

    Naoko Miura, Tokujiro Yano, Fumihiro Shoji, Daigo Kawano, Tomoyoshi Takenaka, Kensaku Ito, Yosuke Morodomi, Ichiro Yoshino, Yoshihiko Maehara

    Anticancer research   29 ( 10 )   4099 - 106   2009.10

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  • [Treatment of malignant pleural mesothelioma--present status and future view].

    Tokujiro Yano, Yosuke Morodomi, Kensaku Ito, Naoko Miura, Tomoyoshi Takenaka, Daigo Kawano, Fumihiro Shoji, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   99 ( 4 )   74 - 9   2008.4

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MISC

  • 【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】遺伝子治療技術を用いた疾患治療 肺癌に対する免疫細胞治療

    諸富 洋介, 原田 結, 米満 吉和

    医学のあゆみ   2023.4

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    肺癌は悪性度の高い疾患であり,わが国を含め世界各国の死因の上位を占めている.しかし,急速な科学技術の発展とともに分子標的薬などが開発され,治療法が一変してきている.そのなかでも,免疫チェックポイント阻害薬(ICI)が肺癌などの固形腫瘍にも有効であることが証明されて以来,悪性腫瘍も免疫の力によって制御できる可能性があることがわかってきた.本稿では,肺癌に対する免疫療法の現状を述べるとともに,特に近年注目を集めているナチュラルキラー細胞(NK細胞)を用いた細胞治療について概説する.(著者抄録)

  • 腹膜播種の全容解明 Sp1によるCXCR4/CXCL12シグナル活性化と細胞外マトリクスを介したスフェア形成

    原田 結, 笠木 勇太, 諸富 洋介, 米満 吉和

    日本癌学会総会記事   2016.10

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  • 有瘻性膿胸に対する持続洗浄を併用した閉鎖式陰圧療法

    諸富 洋介, 岡本 龍郎, 山口 正史, 井上 要二郎, 高田 和樹, 桂 正和, 鈴木 雄三, 藤下 卓才, 北原 大和, 田川 哲三, 竹之山 光広, 一瀬 幸人, 前原 喜彦

    日本呼吸器外科学会雑誌   2015.4

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  • 栄養・感染症・緩和 悪性胸水に対するドレナージおよび胸膜癒着術の原発巣別検討

    諸富 洋介, 岡本 龍郎, 高田 和樹, 桂 正和, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 田川 哲三, 徳永 えり子, 沖 英次, 調 憲, 前原 喜彦

    日本外科学会定期学術集会抄録集   2015.4

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  • 悪性胸膜中皮腫における線溶系分子の発現と臨床病理学的因子に関する検討

    諸富 洋介, 岡本 龍郎, 高田 和樹, 桂 正和, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 田川 哲三, 岡野 慎士, 田口 健一, 竹之山 光広, 一瀬 幸人, 前原 喜彦

    肺癌   2014.10

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  • 腹膜播種の分子細胞メカニズムの解明(Molecular and Cellular Mechanism of Directed Tumor Dissemination in the Peritoneal Cavity)

    原田 結, 笠木 勇太, 諸富 洋介, 米満 吉和

    日本癌学会総会記事   2014.9

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  • 腹膜播種治療モデルにおける癌細胞sphere形成抑制の意義(Sphere formation abolishment decreases peritoneal dissemination in murine model)

    笠木 勇太, 原田 結, 諸富 洋介, 中島 雄一郎, 安藤 幸滋, 今村 裕, 大垣 吉平, 佐伯 浩司, 沖 英次, 米満 吉和, 森田 勝, 藤 也寸志, 前原 喜彦

    日本癌学会総会記事   2014.9

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  • ゲフィチニブで増悪後にエルロチニブへ交替した症例の検討 術後再発症例における特徴

    諸富 洋介, 岡本 龍郎, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 河野 幹寛, 川野 大悟, 前原 喜彦

    日本癌治療学会誌   2014.6

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  • 肺腺扁平上皮癌におけるドライバー遺伝子異常と臨床病理学的因子の検討

    諸富 洋介, 岡本 龍郎, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 河野 幹寛, 川野 大悟, 田口 健一, 竹之山 光広, 一瀬 幸人, 前原 喜彦

    日本呼吸器外科学会雑誌   2014.4

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  • 肺癌の個別化医療時代における外科医の役割 Driver mutationを有する非小細胞肺癌における抗悪性腫瘍薬感受性の特徴

    諸富 洋介, 岡本 龍郎, 吉田 月久, 河野 幹寛, 鈴木 雄三, 藤下 卓才, 北原 大和, 島松 晋一郎, 川野 大悟, 前原 喜彦

    日本外科学会雑誌   2014.3

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  • 癌細胞sphere形成プロセスと腹膜播種のメカニズム(Elucidation of the process of cancer cell sphere formation and peritoneal dissemination)

    笠木 勇太, 原田 結, 諸富 洋介, 安藤 幸滋, 井田 智, 木村 和恵, 沖 英次, 森田 勝, 楠本 哲也, 米満 吉和, 前原 喜彦

    日本癌学会総会記事   2013.10

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  • 腹膜播種がん幹細胞様細胞が足場とするニッシェ様細胞の同定とその標的化(Identification of mesenteric hematopoiesis where is the metastatic niche of tumor dissemination)

    原田 結, 諸富 洋介, 米満 吉和

    日本癌学会総会記事   2013.10

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  • 肺腺扁平上皮癌切除症例の検討

    諸富 洋介, 豊澤 亮, 稲益 英子, 古城 都, 豊川 剛二, 白石 祥理, 竹中 朋祐, 平井 文彦, 山口 正史, 瀬戸 貴司, 竹之山 光広, 一瀬 幸人

    日本呼吸器外科学会雑誌   2013.4

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  • 呼吸器外科領域における基礎研究と治療への展開 腫瘍融解型センダイウイルスベクターを用いた悪性胸膜中皮腫に対する革新的遺伝子治療

    諸富 洋介, 原田 結, 齊藤 智, 竹之山 光広, 一瀬 幸人, 岡本 龍郎, 井上 誠, 長谷川 護, 前原 喜彦, 米満 吉和

    日本外科学会雑誌   2013.3

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  • EML4-ALK融合遺伝子陽性症例での一次化学療法の治療効果

    諸富 洋介, 杉尾 賢二, 豊澤 亮, 稲益 英子, 古城 都, 豊川 剛二, 白石 祥理, 竹中 朋祐, 平井 文彦, 山口 正史, 瀬戸 貴司, 一瀬 幸人

    肺癌   2012.10

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  • 腹膜播種の治療戦略 終末期癌性腹膜炎患者に対する胃瘻造設の有用性

    諸富 洋介, 池田 陽一

    日本外科系連合学会誌   2012.5

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  • Imbalance in VEGF-A/sFLT-1 Enables Malignant Ascites to Resist Dendritic Cell-based Immunotherapy

    M. Sugiyama, Y. Yonemitsu, Y. Kakeji, H. Saeki, E. Oki, Y. Emi, M. Morita, Y. Morodomi, M. Hasegawa, Y. Maehara

    EUROPEAN JOURNAL OF CANCER   2011.9

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  • In vivo imaging可能なマウス同所性胸膜中皮腫移植モデルの確立

    諸富 洋介, 米満 吉和, 矢野 篤次郎, 吉田 月久, 伊藤 謙作, 波呂 祥, 亀山 敏文, 鹿田 康紀, 丸山 理一郎, 前原 喜彦

    日本外科学会雑誌   2011.5

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  • ウロキナーゼ選択性腫瘍融解型センダイウイルスベクターを用いた悪性胸膜中皮腫に対する革新的遺伝子治療

    諸富 洋介, 米満 吉和, 矢野 篤次郎, 喜納 宏昭, 庄司 文裕, 吉田 久美, 上田 泰次, 井上 誠, 長谷川 誠, 前原 喜彦

    日本外科学会雑誌   2010.3

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  • 多発性内臓動脈瘤に対する1手術例

    諸富 洋介, 伊東 啓行, 井口 博之, 内山 秀昭, 米満 吉和, 前原 喜彦

    日本血管外科学会雑誌   2010.2

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    内臓動脈瘤は比較的まれな疾患と考えられているが、画像診断の進歩とともに無症候性の動脈瘤の発見例が増加しつつある。今回検診にて偶然発見された多発性内臓動脈瘤の1例を報告する。症例は73歳女性、検診にて胃十二指腸動脈、固有肝動脈、左肝動脈に各々径3.5cm、1.1cm、0.9cm大の動脈瘤を指摘された。一期的にこれらの動脈瘤を切除し、固有肝動脈は再建した。病理診断は非特異的な動脈瘤の所見であり、炎症や感染の関与は明らかではなかった。(著者抄録)

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Research Projects

  • 血小板をベクターとして用いる癌に対する革新的ドラッグデリバリーシステムの開発

    Grant number:23H02769  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血小板をベクターとして用いる癌に対する革新的ドラッグデリバリーシステムの開発

    Grant number:23H02769  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • がん幹細胞化に関与するSphere形成メカニズムを標的とした革新的治療開発

    Grant number:15H05792  2015 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肺扁平上皮癌における喫煙量別比較に基づいた新たなドライバー遺伝子変異の同定

    Grant number:15K10263  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 悪性胸膜中皮腫の微小環境の特性を標的とした新規治療法の開発

    Grant number:25861255  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

Travel Abroad

  • 2015.11 - 2022.7

    Staying countory name 1:United States   Staying institution name 1:Scripps Research Institute