Updated on 2025/06/27

Information

 

写真a

 
SATORU KOYANAGI
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Professor
Research Center for Education in Health Care System (Concurrent)
Kyushu University Hospital Pharmacy(Concurrent)
Graduate School of Pharmaceutical Sciences Department of Medicinal Sciences(Concurrent)
Graduate School of Pharmaceutical Sciences Department of Clinical Pharmacy(Concurrent)
School of Pharmaceutical Sciences Department of Clinical Pharmacy(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926426611
Profile
Recent developments in our understanding of circadian biology and the availability of tools to characterize this oscillation system indicate that the choosing appropriate dosing time have consequences for the ef cacy and safety of new and existing therapeutic drugs (Chronopharmacotherapy). Progression of this research eld also suggests that many pathological conditions are under the control of the circadian clock. These notions reveal opportunities for new therapeutic strategies. Now novel therapeutic approaches are facilitated by development of chemical probes and synthetic ligands targeted to an increasing number of the key proteins that causing circadian exacerbation of pathological events. The major objective of our research is to understand the molecular mechanisms for day-night changes in the pathological events and the impact of circadian rhythms on the onset of diseases. Based on these mechanism, we attempt to identify new therapeutic target and to develop novel strategy for treatment of diseases.
Homepage

Research Areas

  • Life Science / Clinical pharmacy

Degree

  • Ph.D ( 2000.3 Kyushu University )

Education

  • Kyushu University   大学院博士後期課程修了   薬学研究院

    - 2000.3

      More details

    Country:Japan

Research Interests・Research Keywords

  • Research theme: Investigation of underlying mechanism of circadian variations in the function of pharmacokinetic regulatory factor by RNA editting

    Keyword: RNA editting, pharmacokinetic regulatory factor, circadian rhythm

    Research period: 2018.4 - 2024.3

  • Research theme: Study on the role of circadian clock gene in the oncogenic transformation

    Keyword: Clock genes, Cellular oncogenic transformation

    Research period: 2011.4

  • Research theme: Study on the mechanism for circadian regulation of intractable pain

    Keyword: Neuropathic pain , Cancer, Circadian rhythm

    Research period: 2010.4

  • Research theme: Development of chronopharmacotherapy of anti-cancer drug based on molecular circadian clock

    Keyword: Biological rhythm, clock gene, cell cycle

    Research period: 2005.12 - 2011.3

  • Research theme: Evaluation of the mechanism of circadian time-dependent change of drug efficacy and development of chronodrug delivery system

    Keyword: target molecule, drug metabolism, transporter

    Research period: 2005.12

Awards

  • 2021年度 日本薬学会 学術振興賞

    2021.3   日本薬学会   Chrono-pharmaceutical study based on the molecular mechanism of circadian rhythms in pathological condition and drug efficacy

     More details

    2021年3月に「病態・薬効の概日変動メカニズムを基盤にした時間薬剤学研究」のタイトルにて、日本薬学会学術振興賞を受賞した。

  • 平成25年度日本薬物動態学会奨励

    2013.10   日本薬物動態学会   Chronopharmacokinetic study based on molecular circadian clock

  • 第6回 日本時間生物学会学術奨励賞

    2008.11   日本時間生物学会   体内時計の分子機構を基盤にした抗癌剤の創薬・育薬研究

  • 日本薬学会九州支部学術奨励賞受賞

    2002.12   日本薬学会九州支部   受賞研究題名:生体リズムを考慮した医薬品の適正使用に関する臨床生化学的研究

Papers

  • The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity

    Yasukochi S., Yamakawa W., Taniguchi M., Itoyama S., Tsuruta A., Kusunose N., Yamauchi T., Nakamura R., Matsunaga N., Ohdo S., Koyanagi S.

    Journal of Neuroscience   45 ( 22 )   2025.5   ISSN:02706474

     More details

    Language:English   Publisher:Journal of Neuroscience  

    Neuropathic pain is one of the most intractable pain conditions associated with tumor growth compressing and damaging nerves. A troublesome hallmark symptom of neuropathic pain is hypersensitivity to innocuous stimuli, known as “tactile allodynia,” which is often refractory to currently available analgesics. Diurnal variations in pain hypersensitivity are common in patients with cancer, but the underlying mechanisms are enigmatic. Herein, we report that spinal expression of lipocalin-2 (LCN2) enhances pain sensitivity of NCTC2472 fibrosarcoma-implanted male mice during specific stages of the diurnal cycle. As the tumor grew, interleukin-6 (IL-6) levels increased in the spinal cord of the mice. Increased IL-6 levels stimulated LCN2 expression in spinal microglia, but this expression was periodically repressed by the circadian clock components REV-ERBα and REV-ERBβ. Notably, intraspinal dorsal horn injection of lentiviral vectors expressing REV-ERBα or REV-ERBβ in tumor-bearing mice alleviated tactile allodynia. Furthermore, intrathecal injection of SR9009, a synthetic agonist of REV-ERBs, also attenuated cancer-induced pain hypersensitivity, accompanied by suppressing spinal LCN2 expression. These results suggest that temporal elevation of LCN2 expression decreases the threshold of tactile pain hypersensitivity induced by tumor growth. We propose that the circadian clock component of REV-ERBs is an effective target for alleviation of cancer-induced tactile allodynia, identifying a new class of analgesic agents.

    DOI: 10.1523/JNEUROSCI.1969-24.2025

    Scopus

    PubMed

  • Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins[Formula presented]

    Okano Y., Yamauchi T., Fukuzaki R., Tsuruta A., Yoshida Y., Tsurudome Y., Ushijima K., Matsunaga N., Koyanagi S., Ohdo S.

    Journal of Biological Chemistry   300 ( 11 )   107890   2024.11   ISSN:00219258

     More details

    Language:English   Publisher:Journal of Biological Chemistry  

    Malignant cells exhibit a high demand for amino acids to sustain their abnormal proliferation. Particularly, the intracellular accumulation of cysteine is often observed in cancer cells. Previous studies have shown that deprivation of intracellular cysteine in cancer cells results in the accumulation of lipid peroxides in the plasma membrane and induction of ferroptotic cell death, indicating that cysteine plays a critical role in the suppression of ferroptosis. Herein, we found that the oncogenic accumulation of cysteine also contributes to cancer cell proliferation by promoting the cell cycle progression, which is independent of its suppressive effect on ferroptosis. The growth ability of four types of cancer cells, including murine hepatocarcinoma cells, but not of primary hepatocytes, were dependent on the exogenous supply of cysteine. Deprivation of intracellular cysteine in cancer cells induced cell cycle arrest at the G0/G1 phase, accompanied by a decrease in the expression of cyclin D1 and D2 proteins. The cysteine deprivation–induced decrease in D-type cyclin expression was associated with the upregulation of eukaryotic translation initiation factor 4E binding protein 1, which represses the translation of cyclin D1 and D2 proteins by binding to eukaryotic translation initiation factor 4E. Similar results were observed in hepatocarcinoma cells treated with erastin, an inhibitor of cystine/glutamate antiporter, xCT. These findings reveal an unappreciated role of cysteine in regulating the growth of malignant cancer cells and deepen our understanding of the cytotoxic effect of xCT inhibitor to prevent cancer cell proliferation.

    DOI: 10.1016/j.jbc.2024.107890

    Scopus

    PubMed

  • Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.

    Yamauchi T, Okano Y, Terada D, Yasukochi S, Tsuruta A, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S, Ohdo S

    Cancer & metabolism   12 ( 1 )   23   2024.8   ISSN:2049-3002

     More details

    Language:English  

    DOI: 10.1186/s40170-024-00352-4

    PubMed

  • Suppression of neuropathic pain in the circadian clock-deficient Per2m/m mice involves up-regulation of endocannabinoid system Invited Reviewed International journal

    Yamakawa W, Yasukochi S, Tsurudome Y, Kusunose N, Yamaguchi Y, Tsuruta A, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S

    PNAS Nexus   3 ( 1 )   pgad483   2024.1   eISSN:27526542

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <jats:title>Abstract</jats:title>
    <jats:p>Neuropathic pain often results from injuries and diseases that affect the somatosensory system. Disruption of the circadian clock has been implicated in the exacerbation of the neuropathic pain state. However, in this study, we report that mice deficient in a core clock component Period2 (Per2m/m mice) fail to develop tactile pain hypersensitivity even following peripheral nerve injury. Similar to male wild-type mice, partial sciatic nerve ligation (PSL)-Per2m/m male mice showed activation of glial cells in the dorsal horn of the spinal cord and increased expression of pain-related genes. Interestingly, α1D-adrenergic receptor (α1D-AR) expression was up-regulated in the spinal cord of Per2m/m mice, leading to increased production of 2-arachidonoylglycerol (2-AG), an endocannabinoid receptor ligand. This increase in 2-AG suppressed the PSL-induced tactile pain hypersensitivity. Furthermore, intraspinal dorsal horn injection of adeno-associated viral vectors expressing α1D-AR also attenuated pain hypersensitivity in PSL-wild-type male mice by increasing 2-AG production. Our findings reveal an uncovered role of the circadian clock in neuropathic pain disorders and suggest a link between α1D-AR signaling and the endocannabinoid system.</jats:p>

    DOI: 10.1093/pnasnexus/pgad482

    Scopus

    PubMed

    CiNii Research

  • RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells Reviewed International journal

    Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S

    J Biol Chem   298   102184   2022.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene Reviewed International journal

    Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S

    J Biol Chem   298   100601   2021.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100601

  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed International journal

    Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S

    Nature Commun.   7   2016.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation Reviewed International journal

    Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S

    J Biol Chem   291   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells Reviewed International journal

    Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.

    Cancer Res   8   2013.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway Reviewed International journal

    Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.

    J Biol Chem   21 ( 17224-17231 )   2012.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors Reviewed International journal

    Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.

    Cancer Res.   72 ( 395-401 )   2011.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • cAMP response element-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. Reviewed International journal

    Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S.

    J Biol Chem.   286 ( 32416-32423 )   2011.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice Reviewed International journal

    Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S

    Gastroenterology   135 ( 1636-1644 )   2008.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells Reviewed International journal

    Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Koyanagi S., and Ohdo S.

    Pharmacogenet. Genomics   17 ( 1047-1056 )   2007.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells Reviewed International journal

    Koyanagi S., Kuramoto Y., Nakagawa H., Aramaki H., Ohdo S., Soeda S., Shimeno H.

    Cancer Res.   21 ( 7277-7283 )   2003.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Reviewed International journal

    Ohdo S., Koyanagi S., Suyama H., Higuchi S., Aramaki H.

    Nature Medicine   3 ( 354-360 )   2001.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • N-acetyltransferase 10 promotes glioblastoma malignancy via mRNA stabilization of jumonji and AT-rich interaction domain containing 2

    Inoki T., Tsuruta A., Masakado Y., Kai Y., Yoshida Y., Matsunaga N., Ohdo S., Koyanagi S.

    Journal of Biological Chemistry   301 ( 6 )   108544   2025.6   ISSN:00219258

     More details

    Language:English   Publisher:Journal of Biological Chemistry  

    Glioblastoma (GBM) is the most common and aggressive form of malignant brain cancer, with a poor prognosis and a 5-year survival rate of approximately 15%. The malignancy of GBM, including its treatment resistance and high recurrence rate, is largely attributed to the presence of cancer stem cells. Recent studies have identified the N-acetyltransferase 10 (NAT10), an enzyme responsible for catalyzing N<inf>4</inf>-acetylcytidine (ac4C) modification in RNA, as a key factor in cancer biology, with diverse roles across multiple cancer types. However, the specific contribution of this RNA modification to the malignancy of GBM remains unexplored. Here, we demonstrate that NAT10 expression is associated with poor prognosis in GBM patients and that NAT10 promotes GBM malignancy by enhancing stemness properties in human GBM cell line U251 and A172. A search for the underlying mechanism of NAT10-mediated enhancement of GBM stemness led to identification of polycomb repressive complex 2 (PRC2)-related genes as an epigenetic regulator. NAT10 mediates the acetylation of the coding region of Jumonji and AT-rich Interaction Domain containing 2 (JARID2) mRNA, which results in increased mRNA stability and elevated protein levels. Notably, the knockdown of JARID2 significantly reduced GBM stemness, suppressed tumor growth, and extended the survival of xenograft mice. Our findings suggest that NAT10-mediated acetylation of JARID2 mRNA up-regulates its protein levels, thereby promoting stemness and contributing to the malignancy of GBM. Targeting this NAT10-JARID2 axis may represent a novel therapeutic approach for treatment of GBM.

    DOI: 10.1016/j.jbc.2025.108544

    Scopus

    PubMed

  • Possible prevention of paclitaxel-induced peripheral neuropathy by concomitant use of α1-receptor antagonist based on a retrospective study

    Mori K., Kawashiri T., Mine K., Ishida H., Mori Y., Ueda M., Koura Y., Fujita S., Tsuruta A., Egashira N., Ieiri I., Koyanagi S., Shimazoe T., Kobayashi D.

    Supportive Care in Cancer   33 ( 4 )   316   2025.4   ISSN:09414355

     More details

    Language:English   Publisher:Supportive Care in Cancer  

    Purpose: Paclitaxel and albumin-bound paclitaxel are important anticancer drugs for the treatment of non-small cell lung, pancreatic, gastric, and gynecological cancers; however, they cause peripheral neuropathy as an adverse reaction. Therefore, prophylaxis and treatment for peripheral neuropathy are needed, since there are no sufficient evidence-based strategies to prevent it. Our previous animal research and adverse effect database analysis studies have identified the potential of α1 antagonists to attenuate paclitaxel-induced peripheral neuropathy (PIPN). The purpose of the present study was to investigate the prophylactic potential of α1 antagonists for PIPN in patients with cancer. Methods: Data were collected from the medical records of 673 male patients aged 18 years and older who started treatment with paclitaxel- or albumin-bound paclitaxel-containing regimens at Kyushu University Hospital between January 1, 2013, and December 31, 2019. The two primary outcome measures were PIPN occurrence and paclitaxel discontinuation due to PIPN. Kaplan–Meier curves were generated for cumulative doses and evaluated using the log-rank test. Results: The percentage of patients in whom PIPN occurred (any grade) during the entire study period was 37.4% and 20.0% in without and with α1-receptor antagonist groups, respectively (P = 0.0101, χ<sup>2</sup> test). The incidence of PIPN (any grade) was significantly lower in the α1 antagonists combination group (N = 55) than in the no α1-receptor antagonists group (N = 618) (P = 0.0425, log-rank test). However, there were no significant differences between the two groups in the discontinuation of paclitaxel due to PIPN (P = 0.9654). Conclusions: The present retrospective cohort study may suggest that concomitant use of α1-receptor antagonists may moderate the development of PIPN.

    DOI: 10.1007/s00520-025-09368-y

    Scopus

    PubMed

  • Dopamine receptor D3 affects the expression of Period1 in mouse cells via DRD3–ERK–CREB signaling

    Matsuda M., Nishi T., Yoshida Y., Terada Y., Matsuda-Hayama C., Kumamoto T., Hamamura K., Kohro-Ikeda E., Yasuo S., Koyanagi S., Matsunaga N., Ohdo S.

    Biochemical and Biophysical Research Communications   752   151470   2025.3   ISSN:0006291X

     More details

    Language:English   Publisher:Biochemical and Biophysical Research Communications  

    Circadian rhythm alterations are related to the onset and severity of various diseases. The expression of the dopamine receptor D3 (DRD3) is regulated by clock genes, and DRD3 functional abnormalities are linked to various neurological diseases. However, the relationship between DRD3 function and circadian machinery is unclear. Here, we demonstrate the influence of DRD3 on the circadian machinery. Although the expression of DRD3 in mouse suprachiasmatic nucleus (SCN) did not show a circadian rhythm, the expression of Per1 mRNA was altered in the SCN of Drd3 knockout (Drd3<sup>−/−</sup>) mice compared to that in wild-type (WT) mice. These differences were caused by the upregulation of the DRD3–extracellular signal–regulated kinase–cAMP response element binding protein (DRD3–ERK–CREB) signaling pathway in cultured cells and SCN. In addition, Drd3<sup>−/−</sup> mice demonstrated increased period length of locomotor activity than WT mice only under constant dark conditions. Expression of clock genes in the liver, which does not express DRD3, was affected by the loss of DRD3 only under constant dark conditions, similar to that in the SCN. These results suggest that DRD3 expressed in the SCN regulates the central clock via endogenous ligands and affects peripheral organs. This may provide new evidence to unravel the relationship between dopamine neurotransmission and the circadian clock, which has not yet been fully elucidated.

    DOI: 10.1016/j.bbrc.2025.151470

    Scopus

    PubMed

  • Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense

    Yoshida Y., Tanihara T., Hamasaki K., Tsurusaki F., Fukuda T., Adachi S., Terada Y., Otsuki K., Nishikawa N., Fukuoka K., Tsukamoto R., Hamamura K., Oyama K., Tsuruta A., Mayanagi K., Koyanagi S., Ohdo S., Matsunaga N.

    Theranostics   15 ( 2 )   340 - 361   2025

     More details

    Language:English   Publisher:Theranostics  

    Rationale: Macrophage phagocytosis plays a role in cancer immunotherapy. The phagocytic activity of macrophages, regulated by circadian clock genes, shows time-dependent variation. Intervening in the circadian clock machinery of macrophages is a potentially novel approach to cancer immunotherapy; however, data on this approach are scarce. Microcurrent stimulation (MCS) promotes inflammation, proliferation, and remodeling, suggesting its potential to modulate macrophage function; however, its application has been limited. In this study, we investigated the impact of MCS on macrophage phagocytosis of cancer cells using mouse/human macrophage cell lines and various mouse/human cancer cell lines. Methods: Cells and mice received 300 µA, 400 Hz bidirectional pulsed MCS. Gene expression, protein expression, and phagocytosis activity were assessed in intraperitoneal macrophages collected from mice, as well as in RAW264.7, and THP-1 cells. Flow cytometry, population, phagocytosis activity, RNA-seq, and immunohistochemistry analyses were performed. Results: Noninvasive MCS prevented time-dependent reduction in macrophage phagocytosis of cancer cells by modulating the circadian clock genes. MCS also enhanced phagocytosis in mouse RAW264.7 and human THP-1 cells across various cancer types by promoting actin polymerization; similar in vivo effects were observed in mice. This enhancement occurred in abdominal macrophages of both sexes and was mediated by changes in clock gene expression. Specifically, suppressing the clock gene Per1 nullified the effects of MCS. Moreover, although macrophage phagocytosis typically declined during the dark period, MCS during the light period prevented this reduction. MCS also increased phagocytosis of peritoneally implanted cancer cells (4T1, ID8, and Hepa1-6) in mice, significantly reducing tumor engraftment and growth, and ultimately improving prognosis. Conclusions: The findings of this study suggest that targeting macrophage circadian mechanisms via MCS could enhance cancer immunity, offering new avenues for cancer immunotherapy.

    DOI: 10.7150/thno.100748

    Scopus

    PubMed

  • Proton pump inhibitor concomitant use to prevent oxaliplatin-induced peripheral neuropathy: Clinical retrospective cohort study

    Mine K., Kawashiri T., Mori K., Mori Y., Ishida H., Kudamatsu H., Fujita S., Uchida M., Yamada T., Egashira N., Ieiri I., Koyanagi S., Ohdo S., Shimazoe T., Kobayashi D.

    Pharmacotherapy   2025   ISSN:02770008

     More details

    Language:English   Publisher:Pharmacotherapy  

    Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in a rat model. Therefore, we aimed to test whether the concomitant use of a PPI reduces oxaliplatin discontinuation due to OIPN. Methods: This retrospective study used data from 1015 patients who started treatment with oxaliplatin and evaluated two cohorts (PPI vs. non-PPI). The primary outcome measure was oxaliplatin discontinuation due to OIPN. A Kaplan–Meier curve was generated for cumulative doses and evaluated using the log-rank test and Cox proportional hazards analysis. Results: The log-rank test showed that the number of patients who discontinued oxaliplatin due to OIPN was significantly lower in the PPI group (p = 0.0264). Cox proportional hazards analysis incorporated and analyzed factors previously reported as potentially affecting neuropathy (sex, age, use of PPIs, calcium channel antagonists, opioids and adjuvant analgesics, and the CAPOX [capecitabine + oxaliplatin] regimen). The analysis suggested that the concomitant use of PPIs was a factor in reducing oxaliplatin discontinuation (adjusted hazard ratio [HR] = 0.568, 95% confidence interval [CI], 0.344–0.937, p = 0.0269). Since there were significant differences in some patient demographics between the two groups, propensity score matching was performed to align the patient demographics and then reanalyzed. After propensity score matching, the same analysis as above showed that oxaliplatin discontinuation due to OIPN was significantly less common in the PPI group (p = 0.0081); cox proportional hazards analysis showed that PPI use was a factor that significantly reduced oxaliplatin discontinuation due to OIPN (adjusted HR = 0.478, 95% CI, 0.273–0.836, p = 0.0096). Conclusions: These results suggest that concomitant PPI use may reduce oxaliplatin discontinuation due to OIPN in patients receiving oxaliplatin.

    DOI: 10.1002/phar.70028

    Scopus

    PubMed

  • Monocyte/Macrophage-Specific Loss of ARNTL Suppresses Chronic Kidney Disease-Associated Cardiac Impairment

    Yoshida Y., Nishikawa N., Fukuoka K., Tsuruta A., Otsuki K., Fukuda T., Terada Y., Tanihara T., Kumamoto T., Tsukamoto R., Nishi T., Oyama K., Hamamura K., Mayanagi K., Koyanagi S., Ohdo S., Matsunaga N.

    International Journal of Molecular Sciences   25 ( 23 )   2024.12   ISSN:16616596

     More details

    Language:English   Publisher:International Journal of Molecular Sciences  

    Defects in Aryl hydrocarbon receptor nuclear translocator-like 1 (ARNTL), a central component of the circadian clock mechanism, may promote or inhibit the induction of inflammation by monocytes/macrophages, with varying effects on different diseases. However, ARNTL’s role in monocytes/macrophages under chronic kidney disease (CKD), which presents with systemic inflammation, is unclear. Here, we report that the expression of Arntl in monocytes promoted CKD-induced cardiac damage. The expression of G-protein-coupled receptor 68 (GPR68), which exacerbates CKD-induced cardiac disease, was regulated by ARNTL. Under CKD conditions, GPR68 expression was elevated via ARNTL, particularly in the presence of PU.1, a transcription factor specific to monocytes and macrophages. In CKD mouse models lacking monocyte-specific ARNTL, GPR68 expression in monocytes was reduced, leading to decreased cardiac damage and fibrosis despite no improvement in renal excretory capacity or renal fibrosis and increased angiotensin II production. The loss of ARNTL did not affect the expression of marker molecules, indicating the origin or differentiation of cardiac macrophages, but affected GPR68 expression only in cardiac macrophages derived from mature monocytes, highlighting the significance of the interplay between GPR68 and ARNTL in monocytes/macrophages and its influence on cardiac pathology. Understanding this complex relationship between circadian clock mechanisms and disease could help uncover novel therapeutic strategies.

    DOI: 10.3390/ijms252313009

    Scopus

    PubMed

  • RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway

    Omata Y., Haraguchi M., Yoshinaga S., Ogino T., Okawa M., Tsuruta A., Koyanagi S., Ohdo S.

    Biochemical and Biophysical Research Communications   726   150289   2024.9   ISSN:0006291X

     More details

    Language:English   Publisher:Biochemical and Biophysical Research Communications  

    Among the various RNA modifications, adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) family, ADAR1 and ADAR2, is the most common nucleotide conversion in mammalian cells. The pathological relevance of ADAR expression has been highlighted in recent human genetic studies. Low expression of the ADAR2 gene is correlated with a poor prognosis in breast cancer patients, but the underlying mechanism remains enigmatic. In this study, we constructed Adar2-knockdown (Adar2-KD) murine breast cancer 4T1 cells and observed their reduced susceptibility to chemotherapeutic drug doxorubicin. Downregulation of ADAR2 induced the expression of P-glycoprotein (P-gp), leading to a reduction in the intracellular accumulation of doxorubicin. The upregulation of P-gp occurred at the post-transcriptional level due to the decreased miR-195a-3p function. The search for the underlying cause of the induction of P-gp expression in Adar2-KD 4T1 cells led to the identification of circular RNA (circRNA) circHif1a as a sponge for miR-195a-3p. The enhanced expression of circHif1a inhibited miR-195a-3p function, resulting in the upregulation of P-gp expression. These results suggest that ADAR2 acts as a suppressor of circHif1a biogenesis and then allows miR-195a-3p to interfere with P-gp translation. Our findings may help to improve drug efficacy by clarifying the mechanism of chemoresistance in breast cancer.

    DOI: 10.1016/j.bbrc.2024.150289

    Scopus

    PubMed

  • Dosing Time-Dependent Difference in the Suppressive Effect of Empagliflozin on the Development of Mechanical Pain Hypersensitivity in Diabetic Mice

    Sato A., Yasukochi S., Iwanaka N., Yamauchi T., Tsuruta A., Koyanagi S., Ohdo S.

    Journal of Pharmacology and Experimental Therapeutics   390 ( 2 )   177 - 185   2024.8   ISSN:00223565

     More details

    Language:English   Publisher:Journal of Pharmacology and Experimental Therapeutics  

    A problem for patients with diabetes is the rise of complications, such as peripheral neuropathy, nephropathy, and retinopathy. Among them, peripheral neuropathy, characterized by numbness and/or hypersensitivity to pain in the extremities, is likely to develop in the early stages of diabetes. Empagliflozin (EMPA), a sodium-glucose cotransporter-2 inhibitor, exerts hypoglycemic effects by preventing glucose reabsorption in proximal tubular cells. EMPA can improve cardiovascular and renal outcomes in diabetic patients, but its suppressive effect on the development of diabetic neuropathy remains unclear. In this study, we demonstrated that optimizing the dosing schedule of EMPA suppressed the development of pain hypersensitivity in streptozotocin (STZ)-induced diabetic model mice maintained under standardized light/dark cycle conditions. A single intraperitoneal administration of STZ to mice induced hyperglycemia accompanied by pain hypersensitivity. Although EMPA did not exert anti-hypersensitivity effect on STZ-induced diabetic mice after the establishment of neuropathic pain, the development of pain hypersensitivity in the diabetic mice was significantly suppressed by daily oral administration of EMPA at the beginning of the dark phase. On the other hand, the suppressive effect was not observed when EMPA was administered at the beginning of the light phase. The hypoglycemic effect of EMPA and its stimulatory effect on urinary glucose excretion were also enhanced by the administration of the drug at the beginning of the dark phase. Nocturnal mice consumed their food mainly during the dark phase. Our results support the notion that morning administration of EMPA may be effective in suppressing the development of peripheral neuropathy in diabetic patients. SIGNIFICANCE STATEMENT Empagliflozin, a sodium-glucose cotransporter-2 inhibitor suppressed the development of neuropathic pain hypersensitivity in streptozotocin-induced diabetic model mice in a dosing time-dependent manner.

    DOI: 10.1124/jpet.123.001856

    Scopus

    PubMed

  • Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment

    Yoshida Y., Fukuoka K., Sakugawa M., Kurogi M., Hamamura K., Hamasaki K., Tsurusaki F., Sotono K., Nishi T., Fukuda T., Kumamoto T., Oyama K., Ogino T., Tsuruta A., Mayanagi K., Yamashita T., Fuchino H., Kawahara N., Yoshimatsu K., Kawakami H., Koyanagi S., Matsunaga N., Ohdo S.

    Translational Research   269   31 - 46   2024.7   ISSN:19315244

     More details

    Language:English   Publisher:Translational Research  

    Chronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppressing GPR68 function. Reagents that inhibit the function of GPR68 were explored by high-throughput screening using a medicinal plant extract library (8,008 species), and we identified an extract from Cephalotaxus harringtonia var. nana as a GPR68 inhibitor that suppresses inflammatory cytokine production in a GPR68 expression-dependent manner. Consumption of the extract inhibited inflammatory cytokine expression and cardiac fibrosis and improved the decreased survival attributable to 5/6Nx. Additionally, homoharringtonine, a cephalotaxane compound characteristic of C. harringtonia, inhibited inflammatory cytokine production. Homoharringtonine administration in drinking water alleviated cardiac fibrosis and improved heart failure and survival in 5/6Nx mice. A previously unknown effect of C. harringtonia extract and homoharringtonine was revealed in which GPR68-dependent inflammation and cardiac dysfunction were suppressed. Utilizing these compounds could represent a new strategy for treating GPR68-associated diseases, including CKD.

    DOI: 10.1016/j.trsl.2024.02.004

    Scopus

    PubMed

  • Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior

    Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, Toru Takeo, Naomi Nakagata, Shigekazu Higuchi, Yukihiko Sugimoto, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    International Journal of Molecular Sciences   25 ( 3 )   1841   2024.2   ISSN:16616596 eISSN:14220067

     More details

    Language:English   Publisher:MDPI AG  

    <jats:p>Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor (Ptgfr) has no known relationship with biological rhythms. Here, we first measured the locomotor period lengths of Ptgfr-KO (B6.129-Ptgfrtm1Sna) mice and found that they were longer under constant dark conditions (DD) than those of wild-type (C57BL/6J) mice. We then investigated the clock gene patterns within the suprachiasmatic nucleus in Ptgfr-KO mice under DD and observed a decrease in the expression of the clock gene cryptochrome 1 (Cry1), which is related to the circadian cycle. Moreover, the expression of Cry1, Cry2, and Period2 (Per2) mRNA were significantly altered in the mouse liver in Ptgfr-KO mice under DD. In the wild-type mouse, the plasma prostaglandin F2α (PGF2α) levels showed a circadian rhythm under a 12 h cycle of light–dark conditions. In addition, in vitro experiments showed that the addition of PTGFR agonists altered the amplitude of Per2::luc activity, and this alteration differed with the timing of the agonist addition. These results lead us to hypothesize that the plasma rhythm of PGF2α is important for driving clock genes, thus suggesting the involvement of PGF2α- and Ptgfr-targeting drugs in the biological clock cycle.</jats:p>

    DOI: 10.3390/ijms25031841

    Scopus

    PubMed

    CiNii Research

  • Time-Dependent Differences in Vancomycin Sensitivity of Macrophages Underlie Vancomycin-Induced Acute Kidney Injury

    Yoshida Y., Fukuda T., Fukuoka K., Nagayama T., Tanihara T., Nishikawa N., Otsuki K., Terada Y., Hamamura K., Oyama K., Tsuruta A., Mayanagi K., Koyanagi S., Matsunaga N., Ohdo S.

    Journal of Pharmacology and Experimental Therapeutics   388 ( 1 )   218 - 227   2024.1   ISSN:00223565

     More details

    Language:English   Publisher:Journal of Pharmacology and Experimental Therapeutics  

    Although vancomycin (VCM)—frequently used to treat drug-resistant bacterial infections—often induces acute kidney injury (AKI), discontinuation of the drug is the only effective treatment; therefore, analysis of effective avoidance methods is urgently needed. Here, we report the differences in the induction of AKI by VCM in 1/2-nephrectomized mice depending on the time of administration. Despite the lack of difference in the accumulation of VCM in the kidney between the light (ZT2) and dark (ZT14) phases, the expression of AKI markers due to VCM was observed only in the ZT2 treatment. Genomic analysis of the kidney suggested that the time of administration was involved in VCM-induced changes in monocyte and macrophage activity, and VCM had time-dependent effects on renal macrophage abundance, ATP activity, and interleukin (IL)-1b expression. Furthermore, the depletion of macrophages with clodronate abolished the induction of IL-1b and AKI marker expression by VCM administration at ZT2. This study provides evidence of the need for time-dependent pharmacodynamic considerations in the prevention of VCM-induced AKI as well as the potential for macrophage-targeted AKI therapy.

    DOI: 10.1124/jpet.123.001864

    Scopus

    PubMed

  • Implications of biological clocks in pharmacology and pharmacokinetics of antitumor drugs

    Ohdo S., Koyanagi S., Matsunaga N.

    Journal of Controlled Release   364   490 - 507   2023.12   ISSN:01683659

     More details

    Language:English   Publisher:Journal of Controlled Release  

    Mammalians' circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). SCN control biological rhythms such as the sleep-wake rhythm and homeostatic functions of steroid hormones and their receptors. Alterations in these biological rhythms are implicated in the outcomes of pathogenic conditions such as depression, diabetes, and cancer. Chronotherapy is about optimizing treatment to combat risks and intensity of the disease symptoms that vary depending on the time of day. Thus, conditions/diseases such as allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease, prone to manifest severe symptoms depending on the time of day, would be benefited from chronotherapy. Monitoring rhythm, overcoming rhythm disruption, and manipulating the rhythms from the viewpoints of underlying molecular clocks are essential to enhanced chronopharmacotherapy. New drugs focused on molecular clocks are being developed to improve therapeutics. In this review, we provide a critical summary of literature reports concerning (a) the rationale/mechanisms for time-dependent dosing differences in therapeutic outcomes and safety of antitumor drugs, (b) the molecular pathways underlying biological rhythms, and (c) the possibility of pharmacotherapy based on the intra- and inter-individual variabilities from the viewpoints of the clock genes.

    DOI: 10.1016/j.jconrel.2023.10.049

    Scopus

    PubMed

  • Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease

    Fukuoka K., Yoshida Y., Sotono K., Nishikawa N., Hamamura K., Oyama K., Tsuruta A., Mayanagi K., Koyanagi S., Matsunaga N., Ohdo S.

    Biochemical and Biophysical Research Communications   675   92 - 98   2023.10   ISSN:0006291X

     More details

    Language:English   Publisher:Biochemical and Biophysical Research Communications  

    Chronic kidney disease (CKD) induces an imbalance in the intestinal microbiota, affecting various physiological functions and leading to cardiovascular inflammation and fibrosis. However, the cardiotoxic impact of intestinal microbiota-derived uremic substances in advanced renal dysfunction remains unexplored. Therefore, we developed a 5/6 nephrectomy (5/6Nx) mouse model to investigate the intestinal microbiota and the effects of administering vancomycin (VCM) on the microbiota and the cardiac pathology associated with CKD. Despite VCM administration after the development of irreversible glomerulosclerosis and tubulointerstitial fibrosis, blood indoxyl sulfate and phenyl sulfate levels, which are intestinal bacteria-derived uremic substances, brain natriuretic peptide levels, and the fibrotic area in the heart were decreased. Moreover, VCM administration prevented 5/6Nx-induced weight loss and prolonged survival time. Our findings suggest that VCM-induced changes in the intestinal microbiota composition ameliorate heart failure and improve survival rates by reducing intestinal microbiota-derived cardiotoxic substances despite advanced renal dysfunction. This highlights the potential of using the intestinal microbiota as a target to prevent and treat cardiovascular conditions associated with CKD.

    DOI: 10.1016/j.bbrc.2023.07.015

    Scopus

    PubMed

  • Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins Reviewed International journal

    3. Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Pharmacol   215   15708   2023.7   ISSN:00062952

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Biochemical Pharmacology  

    Proteins localize to their respective organelles in cells. This localization is changed by activation or repression in response to signal transduction. Therefore, the appropriate intracellular localization of proteins is important for their functions to be exerted. However, difficulties are associated with controlling the localization of endogenous proteins. In the present study, we developed a conceptually new method of controlling the intracellular localization of endogenous proteins using bispecific nanobodies (BiNbs). BiNbs recognize proteins expressed in the inner membrane, cytoskeleton, nucleus, and peroxisomes, but not in mitochondria or endoplasmic reticulum. BiNbs designed to recognize β-CATENIN and the intrinsic cytosolic protein VIMENTIN (3 × Flag β-CAT-VIM BiNbs) decreased the β-CATENIN-mediated transactivation of target genes by preventing its nuclear localization. Furthermore, 3 × Flag β-CAT-VIM BiNbs suppressed the proliferation and invasion of the VIMENTIN-expressing breast cancer cell line MDA-MB-231, but not MDA-MB-468, in which the expression of VIMENTIN was defective. The present results revealed that changes in the intracellular localization of specific proteins by BiNbs modulated the physiology and functions of cells. The development of BiNbs to recognize proteins specifically expressed in target cells may be a useful approach for eliciting cell-selective effects.

    DOI: 10.1016/j.bcp.2023.115708

    Scopus

    PubMed

  • Inhibition of tumor-derived C-C motif chemokine ligand 2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice Reviewed International journal

    Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T, Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S

    Mol Pharmacol   104 ( 2 )   73 - 79   2023.6   ISSN:0026895X

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Molecular Pharmacology  

    Neuropathic pain associated with cancers is caused by tumor growth compressing and damaging nerves, which would also be enhanced by inflammatory factors through sensitizing nociceptor neurons. A troublesome hallmark symptom of neuropathic pain is hypersensitivity to innocuous stimuli, a condition known as "tactile allodynia", which is often refractory to NSAIDs and opioids. The involvement of chemokine CCL2 (monocyte chemoattractant protein-1) in cancer-evoked neuropathic pain is well established, but opinions remain divided as to whether CCL2 is involved in the production of tactile allodynia with tumor growth. In this study, we constructed Ccl2 knockout NCTC 2472 (Ccl2-KO NCTC) fibrosarcoma cells and conducted pain behavioral test using Ccl2-KO NCTCimplanted mice. Implantation of naïve NCTC cells around the sciatic nerves of mice produced tactile allodynia in the inoculated paw. Although the growth of Ccl2 KO NCTC-formed tumors was comparable to that of naïve NCTC-formed tumors, Ccl2-KO NCTC-bearing mice failed to show tactile pain hypersensitivity, suggesting the involvement of CCL2 in cancer-induced allodynia. Subcutaneous administration of controlled-release nanoparticles containing the CCL2 expression inhibitor NS-3-008 (1-benzyl-3-hexylguanidine) significantly attenuated tactile allodynia in naïve NCTC-bearing mice accompanied by a reduction of CCL2 content in tumor masses. Our present findings suggest that inhibition of CCL2 expression in cancer cells is a useful strategy to attenuate tactile allodynia induced by tumor growth. Development of a controlled-release system of CCL2 expression inhibitormay be a preventative option for the treatment of cancer-evoked neuropathic pain.

    DOI: 10.1124/molpharm.123.000690

    Scopus

    PubMed

  • Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19

    Hashikawa K.i., Tsuruta A., Yamakawa W., Yasukochi S., Koyanagi S., Ohdo S.

    Biochemical and Biophysical Research Communications   658   88 - 96   2023.5   ISSN:0006291X

     More details

    Language:English   Publisher:Biochemical and Biophysical Research Communications  

    Renewal of retinal photoreceptor outer segments is conducted through daily shedding of distal photoreceptor outer segment tips and subsequent their phagocytosis by the adjacent retinal pigment epithelium (RPE) monolayer. Dysregulation of the diurnal clearance of photoreceptor outer segment tips has been implicated in age-related retinal degeneration, but it remains to be clarified how the circadian phagocytic activity of RPE cells is modulated by senescence. In this study, we used the human RPE cell line ARPE-19 to investigate whether hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>)-induced senescence in ARPE-19 cells alters the circadian rhythm of their phagocytic activity. After synchronization of the cellular circadian clock by dexamethasone treatment, the phagocytic activity of normal ARPE-19 cells exhibited significant 24-h oscillation, but this oscillation was modulated by senescence. The phagocytic activity of senescent ARPE-19 cells increased constantly throughout the 24-h period, which still exhibited blunted circadian oscillation, accompanied by an alteration in the rhythmic expression of circadian clock genes and clock-controlled phagocytosis-related genes. The expression levels of REV-ERBα, a molecular component of the circadian clock, were constitutively increased in senescent ARPE-19 cells. Furthermore, pharmacological activation of REV-ERBα by its agonist SR9009 enhanced the phagocytic activity of normal ARPE-19 cells and increased the expression of clock-controlled phagocytosis-related genes. Our present findings extend to understand the role of circadian clock in the alteration of phagocytic activity in RPE during aging. Constitutive enhancement of phagocytic activity of senescent RPE may contribute to age-related retinal degeneration.

    DOI: 10.1016/j.bbrc.2023.03.070

    Scopus

    PubMed

  • The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells Reviewed International journal

    Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.

    J Biochem   174 ( 2 )   193 - 201   2023.5   ISSN:0021924X

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Biochemistry  

    Diurnal oscillations in the expression of several types of cell surface transporters have been demonstrated in the intestinal epithelial cells, which are mainly generated at transcriptional or degradation processes. Concentrative nucleoside transporter-2 (CNT2) is expressed at the apical site of intestinal epithelial cells and contributes to the uptake of nucleosides and their analogs from the intestinal lumen into the epithelial cells. In this study, we demonstrated that the localization of CNT2 protein in the plasma membrane of mouse intestinal epithelial cells exhibited a diurnal oscillation without changing its protein level in the whole cell. The scaffold protein PDZK1 interacted with CNT2 and stabilized its plasmalemmal localization. The expression of PDZK1 was under the control of molecular components of the circadian clock. Temporal accumulation of PDZK1 protein in intestinal epithelial cells enhanced the plasmalemmal localization of CNT2 at certain times of the day. The temporal increase in CNT2 protein levels at the plasma membrane also facilitated the uptake of adenosine into the intestinal epithelial cells. These results suggest a novel molecular mechanism for the diurnal localization of cell surface transporters and extend our understanding of the biological clock system that generates apparent physiological rhythms.

    DOI: 10.1093/jb/mvad035

    Scopus

    PubMed

  • Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes

    Shohei Uchinomiya, Tomoki Nagaura, Mark Weber, Yuya Matsuo, Naoki Zenmyo, Yuya Yoshida, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo, Naoya Matsunaga, Akio Ojida

    Journal of the American Chemical Society   145 ( 14 )   8248 - 8260   2023.4   ISSN:00027863 eISSN:15205126

     More details

    Language:English   Publisher:American Chemical Society (ACS)  

    Detection of metabolic activity enables us to reveal the inherent metabolic state of cells and elucidate mechanisms underlying cellular homeostasis and growth. However, a fluorescence approach for the study of metabolic pathways is still largely unexplored. Herein, we have developed a new chemical probe for the fluorescence-based detection of fatty acid β-oxidation (FAO), a key process in lipid catabolism, in cells and tissues. This probe serves as a substrate of FAO and forms a reactive quinone methide (QM) as a result of metabolic reactions. The liberated QM is covalently captured by intracellular proteins, and subsequent bio-orthogonal ligation with a fluorophore enables fluorescence analysis. This reaction-based sensing allowed us to detect FAO activity in cells at a desired emission wavelength using diverse analytical techniques including fluorescence imaging, in-gel fluorescence activity-based protein profiling (ABPP), and fluorescence-activated cell sorting (FACS). The probe was able to detect changes in FAO activity induced by chemical modulators in cultured cells. The probe was further employed for fluorescence imaging of FAO in mouse liver tissues and revealed the metabolic heterogeneity of FAO activity in hepatocytes by the combination of FACS and gene expression analysis, highlighting the utility of our probe as a chemical tool for fatty acid metabolism research.

    DOI: 10.1021/jacs.3c02043

    Scopus

    PubMed

    CiNii Research

  • Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19 Reviewed International journal

    Hashikawa KI, Tsuruta A, Yamakawa W, Yasukochi S, Koyanagi S, Ohdo S.

    Biochem Biophys Res Commun   2023.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Fluorescence-based detection of fatty acid β-oxidation in cells and tissues using quinone methide-releasing probes Reviewed International journal

    Uchinomiya S, Nagaura T, Weber M, Matsuo Y, Zenmyo N, Yoshida Y, Tsuruta A, Koyanagi S, Ohdo S, Matsunaga N, Ojida A

    J Am Chem Soc   2023.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Ternary catalytic α-deuteration of carboxylic acids

    Tanaka T., Koga Y., Honda Y., Tsuruta A., Matsunaga N., Koyanagi S., Ohdo S., Yazaki R., Ohshima T.

    Nature Synthesis   1 ( 10 )   824 - 830   2022.10

     More details

    Publisher:Nature Synthesis  

    Efficient and practical construction of deuterated molecules has been a long-standing challenge. Although α-deutero carboxylic acids are ubiquitous structural components that serve as a wide array of synthons, and are thus in high demand, α-selective and mild methods for the deuteration of carboxylic acids have remained unexplored. Here we report the development of a ternary catalytic system for the α-deuteration of carboxylic acids in high yields with excellent levels of α-deuteration. The method shows wide functional group tolerance, including the late-stage deuteration of complex molecules, pharmaceuticals and natural products. Mechanistic studies and pK <inf>a</inf> calculations indicate that the reaction proceeds through the enolization of an acyl pyridinium species. The process was applied to the synthesis of a deuterated EP3 receptor antagonist, with the deutero analogue showing increased metabolic stability in human microsomes compared with the proto compound. [Figure not available: see fulltext.]

    DOI: 10.1038/s44160-022-00139-9

    Scopus

  • Chronopharmacology of immune-related diseases

    Ohdo S., Koyanagi S., Matsunaga N.

    Allergology International   71 ( 4 )   437 - 447   2022.10   ISSN:13238930

     More details

    Language:English   Publisher:Allergology International  

    Clock genes, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN), control various circadian rhythms in many biological processes such as physiology and behavior. Clock gene regulates many diseases such as cancer, immunological dysfunction, metabolic syndrome and sleep disorders etc. Chronotherapy is especially relevant, when the risk and/or intensity of the symptoms of disease vary predicably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. Dosing time influences the effectiveness and toxicity of many drugs. The pharmacodynamics of medications as well as pharmacokinetics influences chronopharmacological phenomena. To escape from host immunity in the tumor microenvironment, cancer cells have acquired several pathways. Immune checkpoint therapy targeting programmed death 1 (PD-1) and its ligand (PD-L1) interaction had been approved for the treatment of patients with several types of cancers. Circadian expression of PD-1 is identified on tumor associated macrophages (TAMs), which is rationale for selecting the most appropriate time of day for administration of PD-1/PD-L1 inhibitors. The therapies for chronic kidney disease (CKD) are urgently needed because of a global health problem. The mechanism of the cardiac complications in mice with CKD had been related the GRP68 in circulating monocytes and serum accumulation of retinol. Development of a strategy to suppress retinol accumulation will be useful to prevent the cardiac complications of CKD. Therefore, we introduce an overview of the dosing time-dependent changes in therapeutic outcome and safety of drug for immune-related diseases.

    DOI: 10.1016/j.alit.2022.06.006

    Scopus

    PubMed

  • Omeprazole Suppresses Oxaliplatin-Induced Peripheral Neuropathy in a Rodent Model and Clinical Database

    Keisuke Mine, Takehiro Kawashiri, Mizuki Inoue, Daisuke Kobayashi, Kohei Mori, Shiori Hiromoto, Hibiki Kudamatsu, Mayako Uchida, Nobuaki Egashira, Satoru Koyanagi, Shigehiro Ohdo, Takao Shimazoe

    International Journal of Molecular Sciences   23 ( 16 )   8859   2022.8   ISSN:16616596 eISSN:14220067

     More details

    Language:English   Publisher:MDPI AG  

    <jats:p>(1) Background: Oxaliplatin is used as first-line chemotherapy not only for colorectal cancer but also for gastric and pancreatic cancers. However, it induces peripheral neuropathy with high frequency as an adverse event, and there is no effective preventive or therapeutic method. (2) Methods: The effects of omeprazole, a proton pump inhibitor (PPI), on oxaliplatin-induced peripheral neuropathy (OIPN) was investigated using an in vivo model and a real-world database. (3) Results: In a rat model, oxaliplatin (4 mg/kg, i.p., twice a week for 4 weeks) caused mechanical hypersensitivity accompanied by sciatic nerve axonal degeneration and myelin sheath disorder. Repeated injection of omeprazole (5–20 mg/kg, i.p., five times per week for 4 weeks) ameliorated these behavioral and pathological abnormalities. Moreover, omeprazole did not affect the tumor growth inhibition of oxaliplatin in tumor bearing mice. Furthermore, clinical database analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) suggests that the group using omeprazole has a lower reporting rate of peripheral neuropathy of oxaliplatin-treated patients than the group not using (3.06% vs. 6.48%, p < 0.001, reporting odds ratio 0.44, 95% confidence interval 0.32–0.61). (4) Conclusions: These results show the preventing effect of omeprazole on OIPN.</jats:p>

    DOI: 10.3390/ijms23168859

    Scopus

    PubMed

    CiNii Research

  • RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells

    Omata Y., Okawa M., Haraguchi M., Tsuruta A., Matsunaga N., Koyanagi S., Ohdo S.

    Journal of Biological Chemistry   298 ( 8 )   102184   2022.8   ISSN:00219258

     More details

    Language:English   Publisher:Journal of Biological Chemistry  

    Multidrug resistance–associated protein 4 (MRP4), a member of the C subfamily of ATP-binding cassette transporters, is highly expressed in the kidneys of mammals and is responsible for renal elimination of numerous drugs. Adenosine deaminase acting on RNA 1 (ADAR1) has been reported to regulate gene expression by catalyzing adenosine-to-inosine RNA editing reactions; however, potential roles of ADAR1 in the regulation of MRP4 expression have not been investigated. In this study, we found that downregulation of ADAR1 increased the expression of MRP4 in human renal cells at the posttranscriptional level. Luciferase reporter assays and microarray analysis revealed that downregulation of ADAR1 reduced the levels of microRNA miR-381-3p, which led to the corresponding upregulation of MPR4 expression. Circular RNAs (circRNAs) are a type of closed-loop endogenous noncoding RNAs that play an essential role in gene expression by acting as miRNA sponges. We demonstrate that ADAR1 repressed the biogenesis of circRNA circHIPK3 through its adenosine-to-inosine RNA editing activity, which altered the secondary structure of the precursor of circHIPK3. Furthermore, in silico analysis suggested that circHIPK3 acts as a sponge of miR-381-3p. Indeed, we found overexpression of circHIPK3 induced the expression of MRP4 through its interference with miR-381-3p. Taken together, our study provides novel insights into regulation of the expression of xenobiotic transporters through circRNA expression by the RNA editing enzyme ADAR1.

    DOI: 10.1016/j.jbc.2022.102184

    Scopus

    PubMed

  • Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development

    Koyanagi S., Kusunose N., Yasukochi S., Ohdo S.

    Journal of Biochemistry   171 ( 5 )   487 - 492   2022.5   ISSN:0021924X

     More details

    Language:English   Publisher:Journal of Biochemistry  

    In addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day-night changes in symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke and chronic pain disorders. Currently, novel therapeutic approaches are facilitated by the development of chemical compounds targeted to key proteins that cause diurnal exacerbation of pathological events. Neuropathic pain is a chronic condition that occurs by tumor-induced nerve compression, cancer cell infiltration into the nerve, diabetes and herpes virus infection. One troublesome hallmark symptom of neuropathic pain is hypersensitivity to normally innocuous stimuli known as 'mechanical allodynia' that is often refractory to common analgesic therapies. Millions of patients worldwide presently endure neuropathic pain. We summarize the recent insights gained into the mechanism of diurnal exacerbation of neuropathic pain hypersensitivity and introduce the strategy of circadian clock-based drug development.

    DOI: 10.1093/jb/mvab143

    Scopus

    PubMed

  • Omeprazole suppresses oxaliplatin-induced peripheral neuropathy in a rodent model and clinical database Reviewed International journal

    Mine K, Kawashiri T, Inoue M, Kobayashi D, Mori K, Hiromoto S, Kudamatsu H, Uchida M, Egashira N, Koyanagi S, Ohdo S, Shimazoe T

    Int J Mol Sci   23   8859   2022.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice Invited Reviewed International journal

    Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S.

    Mol Cancer Res   20 ( 6 )   972 - 982   2022.4   ISSN:15417786 eISSN:15573125

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Association for Cancer Research (AACR)  

    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title/>
    <jats:p>Cancer cells have acquired several pathways to escape from host immunity in the tumor microenvironment. Programmed death 1 (PD-1) receptor and its ligand PD-L1 are involved in the key pathway of tumor immune escape, and immune checkpoint therapy targeting PD-1 and PD-L1 has been approved for the treatment of patients with certain types of malignancies. Although PD-1 is a well-characterized receptor on T cells, the immune checkpoint receptor is also expressed on tumor-associated macrophages (TAM), a major immune component of the tumor microenvironment. In this study, we found significant diurnal oscillation in the number of PD-1–expressing TAMs collected from B16/BL6 melanoma-bearing mice. The levels of Pdcd1 mRNA, encoding PD-1, in TAMs also fluctuated in a diurnal manner. Luciferase reporter and bioluminescence imaging analyses revealed that a NF-κB response element in the upstream region of the Pdcd1 gene is responsible for its diurnal expression. A circadian regulatory component, DEC2, whose expression in TAMs exhibited diurnal oscillation, periodically suppressed NF-κB–induced transactivation of the Pdcd1 gene, resulting in diurnal expression of PD-1 in TAMs. Furthermore, the antitumor efficacy of BMS-1, a small molecule inhibitor of PD-1/PD-L1, was enhanced by administering it at the time of day when PD-1 expression increased on TAMs. These findings suggest that identification of the diurnal expression of PD-1 on TAMs is useful for selecting the most appropriate time of day to administer PD-1/PD-L1 inhibitors.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Implications:</jats:title>
    <jats:p>Selecting the most appropriate dosing time of PD-1/PD-L1 inhibitors may aid in developing cancer immunotherapy with higher efficacy.</jats:p>
    </jats:sec>

    DOI: 10.1158/1541-7786.MCR-21-0786

    Scopus

    PubMed

    CiNii Research

  • Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells Invited Reviewed International journal

    Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.

    Elife   10   e66155   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.66155

  • Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis Reviewed International journal

    Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.

    Nature Commun   12   2883   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-021-23050-x

  • Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord Reviewed International journal

    Yasukochi S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Pharmacol   185   114411   2021.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bcp.2021.114411

    Other Link: https://pubmed.ncbi.nlm.nih.gov/33428896/

  • Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines Reviewed International journal

    Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A

    ACS Med Chem Lett   11   1137 - 1144   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsmedchemlett.9b00574

  • Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity in mice Reviewed International journal

    Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S

    Sci Rep   10   13484   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-70321-6

  • Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins Reviewed International journal

    Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A

    J Am Chem Soc   142   18522 - 18531   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.0c07490

  • Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches Invited Reviewed International journal

    Kusunose N, Tsuruta A, Hamamura K, Tsurudome Y, Yoshida Y, Akamine T, Matsunaga N, Koyanagi S, Ohdo S

    Genes Cells   25   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12758

  • Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs Invited Reviewed International journal

    Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S Ohdo S

    Biochem Biophys Res Commun   519   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.09.021

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes Reviewed International journal

    Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M

    Br J Pharmacol   176   3723 - 3738   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bph.14777

  • Time-dependent changes in the anti-tumor effect of xCT inhibitor erastin in human breast cancer xenograft mice Reviewed International journal

    Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biol Pharm Bull   42   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpb.b19-00546

  • Microcurrent stimulation activates the circadian machinery in mice Reviewed International journal

    Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   513   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.02.022

  • Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene Reviewed International journal

    Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S

    J Biol Chem   294   547 - 558   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Selective and Reversible Modification of Kinase Cysteines with Chlorofluoroacetamides Reviewed International journal

    Shindo N, Fuchida H Sato H, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunag K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A

    Nature Chem Biol   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function Reviewed International journal

    Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S

    Sci Rep   8   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model Reviewed International journal

    Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   503   181 - 187   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system Reviewed International journal

    Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase inhibitor Invited Reviewed International journal

    Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S

    Cancer Res   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Reviewed International journal

    Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells Reviewed International journal

    Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T

    Jpn J Ophthalmol   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice Reviewed International journal

    Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

    J Pharmacol Sci   136 ( 228-233 )   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 母集団薬効解析によるアロプリノールからフェブキソスタットへ切替え時の血清尿酸値に及ぼす影響因子の探索 Reviewed

    緒方貴洸, 兼重 晋, 松尾宏一, 松永直哉, 小柳 悟, 大戸茂弘, 神村英利

    医療薬学(Jpn J Pharmaceu Health Care Sci)   2018.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα Reviewed International journal

    Kanemitsu K, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S.

    J Biol Chem   292 ( 21397-21406 )   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis Reviewed International journal

    Hashikawa K, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

    Scientific Reports   73   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light–dark cycle in mice Reviewed International journal

    Dilixiati A, Koyanagi S, Kusunose N, Matsunaga N, Ohdo S.

    J Pharmacol Sci   134 ( 211-217 )   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 電子カルテ記録に基づいたアロプリノール製剤の母集団薬効動態解析 Reviewed

    緒方貴洸, 兼重 晋, 松尾宏一, 松永直哉, 小柳 悟, 大戸茂弘, 神村英利

    医療薬学(Jpn J Pharmaceu Health Care Sci)   2017.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells Reviewed International journal

    Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Masuda S, Matsunaga N, Koyanagi S, Ohdo S.

    Eur J Pharmacol   800 ( 48-56 )   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed International journal

    Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Kazutaka T, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Makoto T, Inoue K, Ojida A, Koyanagi S, Ohdo S.

    EBioMedicine   13 ( 262-273 )   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock Reviewed International journal

    Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagi S, Ogawa H, Okumura K, Shibata S, Nakao A

    J Allergy Clin Immun   4   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction Invited Reviewed International journal

    Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S

    J Biol Chem   10 ( 4913-4927 )   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression Invited Reviewed International journal

    Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S

    J Biol Chem   13 ( 7017-7028 )   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian modulation in the intestinal absorption of p-glycoprotein substrates in monkeys Reviewed International journal

    Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S:

    Mol Pharmacol   1   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice Reviewed International journal

    Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguichi M, Matsunaga N, Ohdo S

    J Pharmacol Exp Ther   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Modulation of Peroxisome Proliferator-Activated Receptor-alpha Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice Reviewed International journal

    Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S;

    Mol Pharmacol   2 ( 314-322 )   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1 Reviewed International journal

    Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S

    J Biol Chem   36   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice Reviewed International journal

    Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.

    Mol Pharmacol   5 ( 715-722 )   2014.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks. Reviewed International journal

    Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.

    J Invest Dermatol   6   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma Reviewed International journal

    Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S

    Cancer Res   2 ( 543-551 )   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S Reviewed International journal

    Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H

    Scientific Reports   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes Reviewed International journal

    Karakawa S, Miyoshi Y, Konno R, Koyanagi S, Mita M, Ohdo S, Hamase K

    Anal Bioanal Chem   25   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum Reviewed International journal

    Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.

    Mol Pharmacol   5   2013.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Other Link: http://www.ncbi.nlm.nih.gov/pubmed/23429911

  • The molecular clock regulates circadian transcription of tissue factor gene Reviewed International journal

    Oishi K, Koyanagi S, Ohkura N

    Biochem Biophys Res Commun   2 ( 332-335 )   2013.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease Reviewed International journal

    Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.

    Neuromolecular Med   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Other Link: http://www.ncbi.nlm.nih.gov/pubmed/23292542

  • The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis. Reviewed International journal

    Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.

    Hum Immunol.   74   2012.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Induction of Cardiac Fibrosis by beta-Blocker in G Proteinin-dependent and G Protein-coupled Receptor Kinase 5/beta-Arrestin2-dependent Signaling Pathways Reviewed International journal

    Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.

    J Biol Chem   42 ( 35669-35677 )   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Role of Activating Transcription Factor-4 in 24-Hour Rhythm of Serotonin Transporter Expression in the Mouse Midbrain Reviewed International journal

    Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.

    Mol Pharmacol   2 ( 264-270 )   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian Expression of CYP2D6 in Serum-shocked HepG2 Cells. Reviewed International journal

    Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshimura Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.

    Mol Pharmacol   5 ( 739-747 )   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner. Reviewed International journal

    Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

    Toxicology   290 ( 204-208 )   2011.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice Reviewed International journal

    Oishi K, Koyanagi S, Ohkura N.

    Exp Gerontol   12 ( 994-999 )   2011.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Methotrexate chronotherapy is effective against rheumatoid arthritis. Reviewed International journal

    To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K.

    Chronobiol Int.   3 ( 267-274 )   2011.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats Reviewed International journal

    Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K

    Brain   4 ( 1127-1139 )   2011.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes Reviewed International journal

    Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.

    Toxicology   3 ( 144-151 )   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain Reviewed International journal

    Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.

    Mol. Pain   6 ( 83 )   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice Reviewed International journal

    Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.

    Cancer Res.   15 ( 6238-6246 )   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice Reviewed International journal

    Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S.

    Chronobiol Int.   27 ( 1735-1753 )   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hypoxia-Response Plasmid Vector Producing bcl-2 shRNA Enhances the Apoptotic Cell Death of Mouse Rectum Carcinoma Reviewed International journal

    Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S

    J Pharmacol Sci   113 ( 4 )   2010.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner Reviewed International journal

    Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S.

    Mol Pharmacol   2010.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glucocorticoid-dependent expression of O6-methylguanine-DNA methyltransferase gene modulates the dacarbazine-induced hepatotoxicity in mice Reviewed International journal

    Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.

    J Pharmacol Exp Ther   3 ( 782-787 )   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene. Reviewed International journal

    Kim J, Matsunaga N, Koyanagi S, Ohdo S.

    Biochem Pharmacol.   8 ( 1075-1082 )   2009.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation Reviewed International journal

    Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E.

    Life Sci.   9 ( 372-378 )   2009.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride. Reviewed International journal

    Akagi T, Fukagawa T, Kage Y, To H, Matsunaga N, Koyanagi S, Uchida A, Fujii A, Iba H, Ikemura T, Aramaki H, Higuchi S, Ohdo S.

    J Pharmacol Sci   2 ( 265-274 )   2009.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis. Reviewed International journal

    Tojo Y, Hamase K, Konno R, Koyanagi S, Ohdo S, Zaitsu K.

    J Sep Sci.   3 ( 430-436 )   2009.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system Reviewed International journal

    Soeda S., Koyanagi S., Kuramoto Y., Kimura M., Oda M., Kozako T., Hayashida S., Shimeno H.

    Thromb. Haemost.   100 ( 1014-1020 )   2008.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts. Reviewed International journal

    Morikawa A., Hamase K., Miyoshi Y., Koyanagi S., Ohdo S., and Zaitsu K.

    J Chromatogr B Analyt Technol Biomed Life Sci.   875 ( 168-173 )   2008.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function Reviewed International journal

    Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S.

    Life Sci.   83 ( 574-580 )   2008.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling Reviewed International journal

    Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S.

    J. Pharmacol. Sci.   107 ( 401-407 )   2008.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver. Reviewed International journal

    Matsunaga N., Ikeda M., Takiguchi T., Koyanagi S., and Ohdo S.

    Hepatology   48 ( 240-251 )   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Clock gene dysfunction in patients with obstructive sleep apnoea syndrome Reviewed International journal

    Burioka N., Koyanagi S., Endo M., Takata M., Fukuoka Y., Miyata M., Takeda K., Chikumi H., Ohdo S., and Shimizu E.

    Eur. Respir. J.   32 ( 105-112 )   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances Reviewed International journal

    Terazono H., Hamdan A., Matsunaga N., Hayasaka N., Kaji H., Egawa T., Makino K., Shigeyoshi Y., Koyanagi S., and Ohdo S.

    Biochem. Pharmacol.   75 ( 1616-1622 )   2008.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Basic-helix-loop-helix (bHLH) transcription factor DEC2 binds to HIF-1α and negatively regulates the expression of vascular endothelial growth factor. Reviewed International journal

    Sato F., Bhawal U.K., Kawamoto T., Fujimoto K., Imanaka T., Imaizumi T., Kondo J., Noshiro M., Koyanagi S., Kusumi T., Kato Y., and Kijima H.

    Genes Cells   13 ( 131-144 )   2008.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice Reviewed International journal

    Nakagawa H., Takiguchi T., Nakamura M., Furuyama A., Koyanagi S., Aramaki H., Higuchi S., Ohdo S.

    Biochem. Pharmacol.   72   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways Reviewed International journal

    Soeda S, Shinomiya K, Ochiai T, Koyanagi S, Toda A, Eyanagi R, Shimeno H

    Neuroscience   141 ( 101-108 )   2006.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver Reviewed International journal

    Koyanagi S., Suyama H., Kuramoto Y., Matsunaga N., Takane H., Soeda S., Shimeno H., Higuchi S., Ohdo S.

    Endocrinology   147 ( 5037-5040 )   2006.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cell cycle dependent pharmacology of methotrexate in HL-60 Reviewed International journal

    Yamauchi A., Ichimiya T., Inoue K., Taguchi Y., Matsunaga N., Koyanagi S., Fukagawa T., Aramaki H., Higuchi S., Ohdo S.

    J Pharmacol Sci   99 ( 335-341 )   2006.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine Reviewed International journal

    Yoshida M, Kiyofuji H, Koyanagi S, Matsuo A, Fujioka T, To H, Higuchi S, Ohdo S.

    J Pharmacol Sci.   101 ( 77-84 )   2006.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors Reviewed International journal

    Hikishima S., Isobe M., Koyanagi S., Soeda S., Shimeno H., Shibuya S., Yokomatsu T.

    Bioorg. Med. Chem.   14 ( 1660-1670 )   2006.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues Reviewed International journal

    Koyanagi S., Okazawa S., Kuramoto Y., Ushijima K., Shimeno H., Soeda S., Okamura H., Ohdo S.

    Mol. Endocrinol.   20 ( 573-583 )   2006.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones Reviewed International journal

    Kuramoto Y., Hata K., Koyanagi S., Ohdo S., Shimeno H., Soeda S.

    Biochem. Pharmacol   71 ( 1155-1161 )   2006.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glucocorticoid hormone regulates the circadian coordination of ?-opioid receptor expression in mouse brainstem. Reviewed International journal

    Yoshida M., Koyanagi S., Matsuo A., Fujioka T., To H., Higuchi S., Ohdo S.

    J. Pharmacol. Exp. Ther.   3 ( 1119-1124 )   2005.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Chronopharmacological study of antidepressants in forced swimming test in mice Reviewed International journal

    Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., Higuchi S., Ohdo S.

    J. Pharmacol. Exp. Ther.   2 ( 764-770 )   2005.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder Reviewed International journal

    Takimoto M., Hamada A., Tomoda A., Ohdo S., Ohmura T., Sakato H., Kawatani J., Jodoi T., Nakagawa H., Terazono H., Koyanagi S., Higuchi S., Kimura M., Tukikawa H., Irie S., Saito H., Miike T.

    Am. J. Physiol. Regul. Integr. Comp. Physiol.   5 ( 1273-1279 )   2005.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Plasminogen activator inhibitor-1 aids survival of neuritis on neurons derived from pheochromyctoma (PC-12) cells Reviewed International journal

    Soeda S., Imatoh T., Ochiai T., Koyanagi S., Shimeno H.

    Neuroreport   ( 855-858 )   2004.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 24-hr oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression is regulated by clock gene proteins Reviewed International journal

    Nakagawa H., Koyanagi S., Takiguchi T., Soeda S., Shimeno H., Higuchi S., Ohdo S.

    Cancer Res.   64 ( 22 )   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Elevation of de novo ceramide synthesis in tumor masses and a role of the microsomal dihydroceramide synthase Reviewed International journal

    Koyanagi S., Kuga M., Soeda S., Hosoda Y., Yokomatsu T., Takeuchi H., Akiyama T., Shibuya S., Shimeno H.

    Int. J. Cancer   ( 1-6 )   2003.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Optimizing the dosing schedule of TNP-470 enhances its antitumor and anti-angiogenic efficacies Reviewed International journal

    Koyanagi S., Nakagawa H., Kuramoto Y., Ohdo S., Soeda S., Shimeno H.

    J. Pharmacol. Exp. Ther.   2 ( 669-674 )   2003.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Oversulfation of fucoidan enhances its anti-angiogenic and anti-tumor activities Reviewed International journal

    Koyanagi S., Tanigawa N., Nakagawa H., Soeda S., Shimeno H.

    Biochem. Pharmacol.   ( 173-179 )   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism Reviewed International journal

    Koyanagi S., Ohdo S.

    Mol. Pharmacol.   6 ( 1393-1399 )   2002.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • An attempt to promote neovascularization by employing a newly synthesized inhibitor of protein tyrosine phosphatase Reviewed International journal

    Soeda S., Shimada T., Koyanagi S., Yokomatsu T., Murano T., Shibuya S., Shimeno H.

    FEBS Lett.   ( 54-58 )   2002.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Relationship between diurnal rhythm of cell cycle and interferon receptor in implanted-tumor cell Reviewed International journal

    Takane H., Ohdo S., Yamada T., Koyanagi S., Yukawa E., Higuchi S.

    Life Sci.   12 ( 1449-1455 )   2001.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Effects of dosing schedule on pharmacokinetics of alpha-interferon and anti-alpha interferon neutralizing antibody in mice Reviewed International journal

    Wang D.S., Ohdo S., Koyanagi S., Takane H., Aramaki H., Yukawa E., Higuchi S.

    Antimicrob. Agents. Chemother.   ( 176-180 )   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases Reviewed International journal

    Yokomatsu T., Hayakawa Y., Kihara T., Koyanagi S., Soeda S., Shimeno H., Shibuya S.

    Bioorg Med Chem   11 ( 2571-2579 )   2000.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Basis for dosing time-dependent changes in the antiviral activity of interferon-α in mice Reviewed International journal

    Ohdo S., Wang D.S., Koyanagi S., Takane H., Inoue K., Aramaki H., Yukawa E., Higuchi S.

    J Pharmacol Exp Ther   2 ( 488-493 )   2000.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Relationship between 24-hr rhythm in antiviral effect of interferon-β and interferon-α/β receptor expression in mice Reviewed International journal

    Takane H., Ohdo S., Baba R., Koyanagi S., Yukawa E., Higuchi S.

    J. Pharmacol. Sci.   ( 304-312 )   2000.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Chronopharmacological study of interferon-α in mice Reviewed International journal

    Koyanagi S., Ohdo S., Yukawa E., Higuchi S.

    J Pharmacol Exp Ther   1 ( 259-264 )   1997.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Circadian rhythm of fever induced by interferon-alpha in mice Reviewed International journal

    Ohdo S., Koyanagi S., Yukawa E., Higuchi S.

    Life Sci.   8 ( PL95-100 )   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books

  • Perspective 薬剤学 第3版

    大戸茂弘 編著(Role:Joint author)

    京都廣川書店  2019.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • Biological Clock with reference to suprachiasmatic nucleus

    Koyanagi S, Kusunose N, Matsunaga N, Ohdo S.(Role:Joint author)

    北海道大学出版会  2017.11 

     More details

    Language:English   Book type:Scholarly book

  • 時間薬理学による最新の治療戦略

    大戸茂弘 他(Role:Joint author)

    医薬ジャーナル社  2013.4 

     More details

    Language:Japanese   Book type:Scholarly book

  • Perspective 薬剤学

    大戸茂弘 編著(Role:Joint author)

    京都廣川書店  2011.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • Angiogenesis; Functional and Medicinal Foods

    Soeda S., Koyanagi S., Shimeno H.(Role:Joint author)

    Marcel Decker N.Y.  2007.4 

     More details

    Language:English   Book type:Scholarly book

  • 時間学の構築III

    小柳 悟, 大戸 茂弘(Role:Joint author)

    山口大学時間学研究所  2019.3 

     More details

    Responsible for pages:171-192   Language:Japanese   Book type:General book, introductory book for general audience

  • 臨床現場で実践する薬学研究のススメ

    小柳悟、大戸茂弘(Role:Joint author)

    南山堂  2014.10 

     More details

    Responsible for pages:108-113   Language:Japanese   Book type:Scholarly book

    「ウェット」研究でよくあるトラブルへの対処法

▼display all

Presentations

  • 神経障害性疼痛の概日変動メカニズム Invited

    小柳 悟

    第45回日本疼痛学会  2023.12 

     More details

    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福島市   Country:Japan  

  • Circadian clock and Chronopharmacology Invited International conference

    Koyanagi S.

    Annual Meeting Taiwan Pharmaceutical Society  2020.11 

     More details

    Event date: 2021.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:國立陽明大学   Country:Taiwan, Province of China  

  • 概日リズム研究の創薬・医療への応用 Invited

    小柳 悟

    第11回次世代を担う若手医療薬科学シンポジウム  2017.10 

     More details

    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都薬科大学   Country:Japan  

  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of pain hypersensitivity after peripheral nerve injury Invited International conference

    Satoru Koyanagi

    Sapporo Symposium on Biological Rhythm in 2016  2016.11 

     More details

    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Hokkaido University Graduate School of Medicine, Special Conference Room   Country:Japan  

  • Molecular basis for circadian sensitivity of tumor cells to chemotherapeutic agents Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    Spring Annual Convention of Pharmaceutical Society of Korea  2014.4 

     More details

    Event date: 2014.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 神経障害性疼痛の概日リズム形成メカニズムと鎮痛標的分子の探索

    小柳 悟, 楠瀬直喜, 大戸 茂弘

    日本薬学会第134年会  2014.3 

     More details

    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 体内時計による薬物動態の制御と副作用の低減 Invited

    小柳悟、松永直哉、大戸茂弘

    第85回日本薬理学会  2012.3 

     More details

    Event date: 2012.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都国際会議場   Country:Japan  

  • 概日時計の分子機構を基盤にした薬物投与設計と多剤併用療法への応用 Invited

    小柳 悟、松永直哉、大戸茂弘

    日本薬剤学会第26回年会  2011.5 

     More details

    Event date: 2011.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 消化管におけるトランスポーター発現の日内変動を制御する分子メカニズム Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会131回年会  2011.3 

     More details

    Event date: 2011.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:静岡   Country:Japan  

    Molecular machanim for the circadian expression of intestinal transporters

  • 時間薬物療法:体内時計に基づいた創薬・育薬研究 Invited

    小柳悟、松永直哉、大戸茂弘

    第17回日本時間生物学会学術大会  2010.11 

     More details

    Event date: 2010.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:早稲田大学井深ホール   Country:Japan  

  • 分子時計による薬物代謝・排泄の日周リズム制御機構 Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会第129年会  2009.3 

     More details

    Event date: 2009.3

    Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  • Molecular mechanism underlying circadian rhythms of xenobiotic transporters and CYPs Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    19th North American ISSX / 29th JSSX Meeting  2014.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:San Francisco   Country:United States  

  • 〜時間薬理学における基礎と臨床の融合研究〜ヒト近位尿細管細胞におけるRNA編集酵素の概日リズムと薬物排泄トランスポーター発現の制御 Invited

    小柳 悟

    第32回日本医療薬学会年会  2022.9 

     More details

    Event date: 2022.9 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 時間栄養学と時間薬理学の接点 〜 生体膜輸送トランスポーターの発現リズム制御〜 Invited

    小柳 悟

    第9回日本時間栄養学会 教育講演  2022.8 

     More details

    Event date: 2022.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:GLOCAL HOTEL ITOSHIMA    Country:Japan  

  • RNA編集酵素によるヒト近位尿細管細胞における薬物排泄トランスポーター発現の概日リズム制御 Invited

    小柳 悟、小俣 裕司、大戸 茂弘

    第49回日本毒性学会学術年会  2022.6 

     More details

    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • RNA splicingの時刻変動によるP糖タンパク質の発現リズム制御 Invited

    小俣 裕司、山内 智暁、鶴田 朗人、松永 直哉、小柳 悟、大戸 茂弘

    日本薬剤学会第36年会  2021.5 

     More details

    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • オキサリプラチン誘発性の骨髄抑制に及ぼすMRP4発現の概日リズムの影響

    小柳 悟、加藤泉希、鶴留優也、金光拓海、安河内冴、金堂有起、荻野敬史、松永直哉、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

     More details

    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • フェブキソスタットのBCRP機能阻害によるスルファサラジンの消化管吸収改善と末梢神経障害性疼痛緩和作用に及ぼす効果

    安河内冴、山川稚葉、山内智暁、小俣裕司、鶴田朗人、松永直哉、小柳悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

     More details

    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • RNA編集酵素ADAR1によるヒト腎近位尿細管上皮細胞でのP糖タンパク質発現の概日リズム制御

    小俣裕司、大川ませ梨、鶴田朗人、松永直哉、小柳悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

     More details

    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • RNA編集酵素ADAR1による「環状RNA」発現制御を介したヒト腎細胞におけるMRP4発現制御機構の解析

    小俣裕司、小柳 悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

     More details

    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 白金製剤オキサリプラチン誘発の骨髄抑制に及ぼす薬物排泄トランスポーター MRP4の概日リズムの影響

    小柳 悟、加藤泉希、鶴留優也、安河内 冴、松永直哉、大戸茂弘

    メタルバイオサイエンス研究会2021  2021.10 

     More details

    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • Basis for generation of pathological circadian rhythms and its application for drug development Invited International conference

    Satoru Koyanagi

    The 94th Annual Meeting of the Japanese Biochemical Society  2021.11 

     More details

    Event date: 2022.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • がん化した時計遺伝子の機能不全細胞における薬剤耐性能獲得機構 Invited

    小柳悟、松永直哉、大戸茂弘

    第27回日本時間生物学会学術大会  2020.9 

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web開催   Country:Japan  

  • Chronopharmacology based on circadian clock-regulated xenobiotic transporters Invited International conference

    Koyanagi Satoru

    2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX  2018.10 

     More details

    Event date: 2018.10 - 2020.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:金沢   Country:Japan  

  • Circadian clock regulation of intra-individual variations in drug disposition; Translational research of chrono-pharmacokinetics Invited International conference

    Satoru Koyanagi

    International Conference of Precision Medicine  2017.11 

     More details

    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taipei Medical University   Country:Taiwan, Province of China  

  • Translational research of chrono-pharmacokinetics Invited International conference

    Satoru Koyanagi

    Joint Symposium Hokkaido Univ. Taipei Medical Univ. Kyushu Univ.  2017.9 

     More details

    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:九州大学   Country:Japan  

  • 時間薬理学的アプローチによる難治性がんの治療戦

    小柳 悟, 片宗 千春, 松永 直哉, 大戸 茂弘

    第92回日本薬理学会年会  2018.3 

     More details

    Event date: 2018.3 - 2020.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Molecular basis for chronopharmacokinetics and chronopharmacology of chemotherapeutic agents Invited International conference

    小柳悟、松永直哉、大戸茂弘

    日本薬物動態学会第30回年会  2016.11 

     More details

    Event date: 2016.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 薬物動態の概日リズム研究におけるトランスレーショナルリサーチ Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会第136年会  2016.3 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜市   Country:Japan  

  • 培養細胞での概日時計メカニズムを応用した細胞がん化抑制機構の解明 Invited

    小柳 悟

    日本動物実験代替法学会第26回大会  2013.12 

     More details

    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 概日時計因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御 Invited

    小柳 悟, 松永 直哉, 大戸 茂弘

    第35回生体膜と薬物の相互作用シンポジウム  2013.11 

     More details

    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 時間薬物動態におけるトランスレーショナルリサーチ

    小柳 悟, 松永 直哉, 大戸 茂弘

    第20回日本時間生物学会学術大会  2013.11 

     More details

    Event date: 2013.11 - 2013.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Molecular mechanism regulating circadian expression of drug metabolism enzymes in human Invited

    Koyanagi Satoru, matsunaga naoya, shigehiro ohdo

    第28回日本薬物動態学会  2013.10 

     More details

    Event date: 2013.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 転写因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御 Invited

    小柳 悟

    第8回トランスポーター研究会  2013.6 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 6年制の薬学部学生に対する研究指導 〜医療薬学系教官の立場から〜

    小柳 悟

    第27回日本薬学会九州支部大会  2010.12 

     More details

    Event date: 2010.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎大学薬学部   Country:Japan  

  • Manipulation of feeding schedule can modulate the antiviral effect of Interferon-α

    Hamdan AM, Matsunaga N, Satoru Koyanagi S, Ohdo S.

    Niigata World Forum on Foods and Flowers 2008  2008.11 

     More details

    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 抗がん剤の効果・毒性の日内変動を制御する分子メカニズム Invited

    小柳悟、松永直哉、大戸茂弘

    第4回日本緩和医療薬学会年会  2010.9 

     More details

    Event date: 2010.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島市民会館   Country:Japan  

  • 体内時計の分子機構を基盤にした薬物投与設計 Invited

    小柳悟、松永直哉、大戸茂弘

    医療薬学フォーラム2010/第18回クリニカルファーマシーシンポジウム  2010.7 

     More details

    Event date: 2010.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島国際会議場   Country:Japan  

  • 抗がん剤の時間薬理 Invited

    大戸茂弘、松永直哉、小柳悟

    医療薬学フォーラム2009 第17回クリニカルファーマシーシンポジウム  2009.7 

     More details

    Event date: 2009.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Chrono-drug delivery of antitumor drugs: molecular clock mechanisms Invited International conference

    Ohdo S, Matsunaga N, Koyanagi S

    International Joint Seminar  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Venue:Fukuoka   Country:Japan  

  • 薬物活性リズムの体内時計の分子機構 Invited

    大戸茂弘、松永直哉、小柳悟

    第15回日本時間生物学会学術大会  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山大学   Country:Japan  

  • Dosing-time dependent antitumor effects of Transferrin-Liposome Oxaliplatin (Tf-Lip-L-OHP) in tumor bearing mice International conference

    Ohdo S, Okazaki F, Maruyama K, Matsunaga N, Koyanagi S.

    11th Liposome Research Days Conference  2008.7 

     More details

    Event date: 2008.7

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Chronopharmacology of interferon-α in mice International conference

    Ohdo S., Koyanagi S., Yukawa E, Higuchi S., Yoshiyama Y., Nakano S. Ogawa N.

    The 8th International conference of chronopharmacology and chronotherapeutics  1999.8 

     More details

    Venue:Williamsburg   Country:United States  

  • 時計遺伝子に着目した時間治療の可能性 Invited

    小柳 悟

    日本薬学会第122回年会  2002.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉   Country:Japan  

  • Molecular basis for circadian expression of cascular endothelial growth factor in tumor cells International conference

    Kuramoto Y., Koyanagi S., Nakagawa H., Aramaki H., Ohdo S., Soeda S., Shimeno H.

    The 1st World Congress of Chronobiology  2003.6 

     More details

    Presentation type:Oral presentation (general)  

    Venue:Sapporo   Country:Japan  

  • Studies on optimizing dosing schedule of angiogenesis inhibitor International conference

    Nakagawa H., Koyanagi S., Takiguchi T., Kuramoto Y., Ohdo S., Higuchi S.

    2nd Pharmaceutical Sciences World Congress  2004.6 

     More details

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 体内時計とがんの時間治療 Invited

    小柳 悟

    日本薬学会第125回年会  2005.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Circadian clock and chronopharmacology of anti-tumor drug Invited

    Koyanagi S.

    8th International symposium on recent advances in drug discovery and development  2007.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:Yeungnam University   Country:Korea, Republic of  

  • 時計遺伝子とがんの時間薬物療法 Invited

    小柳 悟

    時間循環血圧研究会  2007.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine International conference

    Ohdo S., Murakami Y., Higashi Y., Matsunaga N., Koyanagi S.

    2007.6 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:Kanazawa   Country:Japan  

  • 生体リズムを駆使した抗がん剤の時間治療 Invited

    小柳 悟

    第80回日本薬理学会  2007.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • Chronopharmacology of angiogenesis inhibitors Invited International conference

    Koyanagi S.

    2nd World Congress of Chronobiology  2007.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:Tokyo   Country:Japan  

  • Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine International conference

    Ohdo S., Murakami Y., Higashi Y., Matsunaga N., Koyanagi S.

    2nd World Congress of Chronobiology  2007.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells. International conference

    Koyanagi S., Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Ohdo S.

    2nd World Congress of Chronobiology  2007.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • Chronopharmacological study of hepatotoxicity induced by acetaminopehn in mice International conference

    Matsunaga N., Ikeda M., Takiguchi T., Koyanagi S., Ohdo S.

    2nd World Congress of Chronobiology  2007.11 

     More details

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 体内時計の分子機構を駆使したがん時間化学療法の可能性 Invited

    小柳 悟

    第1回次世代を担う若手医療薬科学シンポジウム  2007.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 食品の機能性を時間生物学的視点から考える Invited

    大戸茂弘、小柳悟、松永直哉

    日本農芸化学会2012年度大会  2012.3 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 生体リズム研究と時間治療の動向と展望

    小柳 悟

    医療薬学フォーラム2012 第20回クリニカルファーマシーシンポジウム  2012.7 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Chronopharmacology based on molecular clock Invited

    大戸茂弘、小柳悟、松永直哉

    第76回日本循環器学会学術集会  2013.3 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • がん細胞の抗がん剤感受性の日周リズム制御機構

    小柳 悟, 松永 直哉, 大戸 茂弘

    第86回日本薬理学会学術大会  2013.3 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 生体リズムにマッチしたクロノセラピィー Invited

    大戸茂弘、小柳悟、松永直哉

    日本薬剤学会 第28年会  2013.5 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 時間薬理学の現状と将来 Invited

    大戸茂弘、小柳悟、松永直哉

    第128回 日本薬理学会関東部会  2013.7 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング Invited

    大戸茂弘、小柳悟、松永直哉

    第86回 日本生化学会  2013.9 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Chronopharmacological aspects of transporters Invited

    大戸茂弘、小柳悟、松永直哉

    日本薬物動態学会 第28回年会  2013.10 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Exploration of analgesic target for neurophatic pain based on the molecular mechanism of circadian rhythm in allodynia Invited

    Koyanagi Satoru, Naoki Kusunose, Shigehiro Ohdo

    第87回日本生化学会  2014.10 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 概日時計を活用した疾患の予防・診断・治療

    小柳 悟、藤 秀人

    第21回日本時間生物学会学術大会  2014.11 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Molecular basis of chrono-pharmacokinetics and chrono-pharmacology Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    Awaji-Symposium, “RNA and Clock”  2015.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:兵庫県   Country:Japan  

  • Molecular mechanism underlying circadian rhythms in drug metabolism and excretion Invited

    小柳 悟、松永直哉、大戸茂弘

    第42回 日本毒性学会学術年会  2015.6 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:金沢市   Country:Japan  

  • 場タンパク質(NHERF1)の発現リズムに基づいた肝細胞膜トランスポーターの機能制御

    鶴留優也,小柳 悟,松永直哉,大戸茂弘

    日本薬剤学会第31年会  2016.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:岐阜市   Country:Japan  

  • 眼内VEGFの時計遺伝子DEC2依存的発現制御

    楠瀬直喜,小林義行,吉田茂生,木許賢一,小柳悟,大戸茂弘,久保田敏昭

    第20回 眼創傷治癒研究会  2016.8 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 細胞がん化に及ぼす時計遺伝子の機能的差異の影響:培養細胞を用いた検討

    片宗千春,白水翔也,橋川健一,松永直哉,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 肝細胞癌の発症を抑制する新規低分子化合物の探索

    東和博,鶴田朗人,渡遣美弥子,松永直哉,柿本啓輔,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 転写因子に着目した難治性乳がんの新規治療法の検討

    荻野敬史,松永直哉,原幸稔,田仲孝広,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 細胞がん化時における異常増殖能の獲得に必要なアミノ酸の同定

    白水翔也,山口悠太,片宗千春,橋川健一,村上千帆,松永直哉,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 培養尿細管上皮細胞を用いた薬剤性腎障害の評価系構築

    坂本裕哉,矢野貴久,竹下亜希,稲垣芙美佳,松永直哉, 小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 培養細胞を用いた皮膚の分子時計解析アクアポリン3発現の概日リズム制御機構

    松永直哉,一町和史,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 体内時計の分子機構を基盤とした、虚血網膜におけるVEGF発現上昇メカニズムの解明

    楠瀬直喜,小林義行,吉田茂生,木許賢一,小柳悟,大戸茂弘,久保田敏昭

    第29回日本動物実験代替法学会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • バンコマイシン誘発尿細管上皮細胞アポトーシスにおけるROSおよびMAPKの役割

    坂本裕哉, 矢野貴久, 稲垣芙美佳, 松永直哉, 小柳 悟, 大戸茂弘

    第69回 日本薬理学会西南部会  2016.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:松山市   Country:Japan  

  • がん細胞の異常増殖能獲得に寄与するアミノ酸の同定およびアミノ酸取込み阻害剤による細胞増殖抑制効果の検討

    白水翔也,山口悠太,松永直哉,小柳悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • バンコマイシンによる尿細管上皮細胞障害におけるミトコンドリアの役割と抗酸化薬の効果

    稲垣芙美佳,矢野貴久,坂本裕哉,松永直哉,小柳悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • オキサリプラチンの骨髄抑制作用に及ぼすMRP4発現の概日リズムの影響

    加藤泉希,鶴留優也,金堂有起,森田朱莉,松永直哉,小柳 悟大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • Aldehyde dehydrogenase活性を指標としたトリプルネガティブ乳がんの時間薬理学的研究

    原 幸稔,松永直哉,荻野敬史,田仲孝広,岩本真由香,楠瀬直喜,小柳 悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • 電子カルテ記録に基づいた母集団薬効動態解析によるアロプリノールの先発品と後発品の治療効果の比較

    緒方貴洸, 兼重 晋, 松尾宏一, 楠瀬直喜, 松永直哉, 神村英利, 小柳 悟, 大戸茂弘

    第2回臨床薬理学会九州・沖縄地方会  2017.6 

     More details

    Presentation type:Oral presentation (general)  

    Venue:那覇市   Country:Japan  

  • 慢性腎臓病時の炎症概日リズムに基づく新規治療薬の開発

    松永直哉、鶴田朗人、吉田優哉、中尾崇治、高露 恵理子、濱村賢吾、渡邊美弥子、近藤英明、小柳 悟、大戸茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 慢性腎臓病モデルマウスにおける分子時計を介した腎‐肝‐腎連関機構の解明

    中尾崇治、松永直哉、吉田優哉、鶴田朗人、濵村賢吾、近藤英明、小柳 悟、大戸茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 足場タンパク質の発現リズムに基づいた脂肪酸取り込みトランスポーターの機能シミュレーションモデルの構築

    森田朱莉、鶴留優也、赤嶺孝祐、金堂有起、嶋岡雄大、楠瀬直喜、松永直哉、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • 概日リズムの制御機構におけるドパミン D3 受容体の機能解析

    羽山千尋、松田将希、吉田優哉、松永直哉、楠瀬直喜、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • 慢性腎臓病モデルマウスにおける分子時計を介した 腎・心病態悪化機構の解明

    吉田優哉、松永直哉、鶴田朗人、中尾崇治、羽山千尋、黒木雅礼、楠瀬直喜、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • 足場タンパク質 NHERF1 の発現リズムに基づいた 肝細胞膜トランスポーターの機能制御

    鶴留優也、小柳 悟、片宗千春、森田朱莉、金光拓海、金堂有起、加藤泉希、楠瀬直喜、松永直哉、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • The role of molecular clock in the alterations of hepatic metabolism in chronic kidney disease. International conference

    Ohdo S, Matsunaga N, Koyanagi S

    2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX  2018.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:Kanazawa   Country:Japan  

  • Circadian scaffolding function of NHERF1 for plasmalemmal expression of xenobiotic transporter in mouse liver,

    鶴留優也 片宗千春 楠瀬直喜 松永直哉 小柳悟 大戸茂弘

    第25 回 日本時間生物学会学術大会  2018.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 体内時計の分子機構を基盤とした、虚血網膜におけるVEGF 発現上昇メカニズムの解明

    楠瀬直喜、赤嶺孝祐、松永直哉、小柳 悟、 久保田敏昭、大戸茂弘

    第25 回 日本時間生物学会学術大会  2018.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 概日時計機構を基盤とした腎障害誘発心線維化の新規メカニズム解明

    吉田優哉、 松永直哉、 鶴田朗人、 楠瀬直喜、 小柳 悟、大戸茂弘

    第25 回 日本時間生物学会学術大会  2018.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 既存薬ライブラリーを用いた新規神経障害性疼痛治療薬の探索

    安河内冴、楠瀬直喜、山口悠太、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 炎症関連受容体Xを標的とした慢性腎不全時の心炎症抑制化合物の探索

    山口悠太、楠瀬直喜、安河内冴、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 薬剤経眼投与による生体リズム調整法の構築

    嶋岡雄大、楠瀬直喜、鶴留優也、松永直哉、小柳 悟、大戸茂

    第35回日本薬学会九州支部大会  2018.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Ccrfを標的とした新規慢性肝炎治療薬の開発

    柴田愛実、鶴田朗人、松永直哉、楠瀬直喜、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 難治性ヒト乳がん細胞の薬剤抵抗性を改善する化合物の探索

    荻野敬史、松永直哉、岩本真由香、楠瀬直喜、小柳 悟、大戸茂弘

    日本動物実験代替法学会第31回大会  2018.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • Circadian clock-based strategy for exploration of approved drug to alleviate neuropathic pain hypersensitivity International conference

    Sai Yasukochi, Noaki Kusunose, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    The 48th NAITO CONFERENC  2019.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:札幌市   Country:Japan  

  • 神経障害性疼痛の概日リズム制御因子を標的とした既存薬ライブラリーからの鎮痛候補薬の探索

    安河内冴、楠瀬直喜、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第13回 次世代を担う若手医療薬科学シンポジウム  2019.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:岐阜市   Country:Japan  

  • 単球に着目した慢性腎臓病時における心臓病態悪化の新規メカニズム解明

    吉田優哉、松永直哉、濵村賢吾、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • がん幹様細胞における転写因子の発現に着目した難治性乳がんの新規治療法に関する検討

    荻野歴史、松永直哉、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • がん細胞におけるシスチン取込みトランスポーター活性の概日リズム制御機構の解析

    山内智暁、楠瀬直喜、白水朔也、松永直哉、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 脊髄内の脂質メデイエーターに着目したがん性癖痛の概日リズム制御機構の解析

    糸山さやか、安河内冴、楠瀬直喜、松永直哉、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 体内時計の分子機構に及ぼすマイクロ電流刺激の影響

    北城直樹、松永直哉、吉田優哉、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 転写後過程おける薬物代謝酵素CYP3A4活性の概日リズム制御の解析

    田尻楓、小俣裕司、松永直哉、小柳悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 鎮痛増悪分子SGK-1を標的としたスルファサラジンによる神経障害性疼痛に対する新規治療戦略の構築

    安河内冴,楠瀬直喜,山内智暁,山川稚葉,小俣裕司,鶴田朗人,松永直哉, 小柳悟

    第14回 次世代を担う若手医療薬科学シンポジウム  2020.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 腎障害誘発性の心炎症、線維化抑制化合物の探索

    北川陽也,松永直哉,吉田優哉, 黒木雅礼, 鶴田朗人,小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 時間薬剤学的アプローチによる神経障害性疼痛に対する鎮痛化合物の探索と新規治療戦略の構築

    安河内冴,楠瀬直喜, 山内智暁, 小俣裕司, 鶴田朗人, 松永直哉, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • がん幹様細胞における転写因子の発現に着目した難治性乳がんの新規治療法に関する検討

    荻野敬史,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 肝臓がんの発症を抑制する新規抗炎症化合物の探索

    椎葉友輝, 松永直哉,鶴田朗人,柿本啓輔, 渡邊美弥子,小柳 悟, 大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • アクアポリン3に着目した皮膚の分子時計機構

    正門佳法,一町和史,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • パーキンソン病モデルマウスにおける生体リズム障害誘発機構

    西川直希,林亜錦,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • マウス腎がんを対象としたエベ口リムスの時間薬物治療に関する検討

    谷原智仁, 岡崎裕之,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Transferrin修飾liposome製剤を用いた癌の時間治療に関する検討

    金谷大騎, 岡崎史泰,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • がん細胞におけるシスチン取込み卜ランスポーターを標的とした杭がん剤の時間薬理学的検討

    山内皆暁,楠瀬直喜, 白水翔也,松永直哉, 小柳悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • RNA編集酵素ADAR1によるヒト腎細胞でのP糖タンパク質発現の概日リズム制御機構

    小俣裕司, 山内智暁, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘

    日本薬学会第141年会  2021.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 全身機能から新たな疼痛制御メカニズムを探る 神経障害性疼痛の概日変動メカニズム

    小柳 悟

    PAIN RESEARCH  2023.12  (一社)日本疼痛学会

     More details

    Language:Japanese  

  • 体内時計の変調がもたらす健康障害と疾患:メカニズムの理解と予防策の構築に向けて 概日時計分子の機能変調による細胞のがん化・薬剤耐性獲得の分子機構

    小柳 悟

    The Journal of Toxicological Sciences  2024.7  (一社)日本毒性学会

     More details

    Language:Japanese  

▼display all

MISC

  • 【概日時計が制御する多面的な生理機構】疼痛疾患における概日リズム

    小柳 悟

    医学のあゆみ   292 ( 10 )   847 - 852   2025.3   ISSN:0039-2359

     More details

    Language:Japanese   Publisher:医歯薬出版(株)  

    <文献概要>痛みは,組織の損傷に対する警告や危険から回避するための重要な感覚情報であるが,"痛みが3ヵ月以上持続する"または"通常の治療期間を超えて持続する痛み"は"慢性疼痛"と定義され,高齢者における有病率は20%近くに達する.慢性疼痛の原因は多岐にわたるが,その多くは夜間から早朝にかけて痛みが増悪する特徴を示す.慢性疼痛のなかでも神経障害性疼痛は,衣服が肌に触れるような軽い刺激でも激しい痛みを引き起こす"アロディニア(疼痛過敏)"を特徴とし,患者のQOLを著しく低下させているが,その症状も1日のなかの特定の時間帯に悪化する.最近の研究で,概日時計の分子機構と疼痛の発症や増悪につながるシグナル経路との関わりが明らかにされつつあり,新たな鎮痛標的としての評価・応用が期待される.

  • Chronopharmacology of immune-related diseases Reviewed

    1. Ohdo S, Koyanagi S, Matsunaga N

    Allergol Int   2022.10

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.alit.2022.06.006

  • Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development Reviewed

    Koyanagi S, Kusunose N, Yasukochi S, Ohdo S.

    J Biochem   2021.11

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1093/jb/mvab143

  • Chronopharmacological strategies focused on chrono-drug discovery Reviewed

    Ohdo S, Koyanagi S, Matsunaga N

    2021.5

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.pharmthera.2019.05.018

  • 足場タンパク質によるトランスポーター細胞膜局在の概日リズム制御

    鶴留優也, 小柳 悟

    ファルマシア   2019.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 時間医薬研究の現状と展望 Reviewed

    小柳  悟

    医薬ジャーナル   2018.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 慢性疼痛の概日変動メカニズムと新しい治療標的 Reviewed

    楠瀬直樹, 小柳 悟, 松永直哉, 大戸茂弘

    医薬ジャーナル   2018.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 薬物動態の概日リズムと種差

    小柳 悟, 大戸茂弘

    Drug Delivery System   2017.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi.org/10.2745/dds.32.418

  • 時間薬理学における分子基盤

    小柳悟

    生化学   2014.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 薬物動態の概日リズムとDDS開発

    小柳悟、大戸茂弘

    Drug Delivery System   2014.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計による医薬品体内動態の概日リズム制御

    小柳 悟、松永 直哉、大戸 茂弘

    Drug Metabolism and Pharmacokinetics   2013.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体リズムと治療

    大戸茂弘、小柳悟、松永直哉

    Drug Metabolism and Pharmacokinetics   2013.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計による薬物輸送トランスポーターの概日リズム制御

    小柳 悟, 大戸茂弘

    週刊 医学のあゆみ   2013.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • トランスフェリン受容体と時間薬物送達システム

    松永直哉、岡崎史泰、小柳悟、大戸茂弘

    日本臨床   2013.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計を基盤とした時間治療

    大戸茂弘、小柳悟、松永直哉

    BIO Clinica   2012.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 分子時計を基盤にした薬物動態の日内変動

    大戸茂弘、小柳悟、松永直哉

    臨床薬理   2012.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Molecular basis of chronopharmaceutics

    Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.

    J Pharm Sci   2011.9

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Chronopharmacology

    Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.

    Nihon Yakurigaku Zasshi   2011.5

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Asthma: Chronopharmacotherapy and the molecular clock

    Burioka N, Fukuoka Y, Koyanagi S, Miyata M, Takata M, Chikumi H, Takane H, Watanabe M, Endo M, Sako T, Suyama H, Ohdo S, Shimizu E

    Adv Drug Deliv Rev.   2010.6

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock

    Ohdo S, Koyanagi S, Matsunaga N.

    Adv Drug Deliv Rev   2010.6

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 時間薬物動態

    小柳悟、松永直哉、大戸茂弘

    医薬ジャーナル   2009.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計の分子機構を基盤にした抗がん剤の創薬・育薬研究

    小柳 悟

    時間生物学   2009.6

  • 生体リズムとDDS

    松永直哉、小柳悟、大戸茂弘

    医薬ジャーナル   2009.3

  • 創薬・育薬を指向した薬効評価学的研究および時間薬剤学的研究

    大戸茂弘、小柳悟、松永直哉

    薬剤学   2008.5

  • 血管新生のサーカディアンリズムと時間治療学

    小柳 悟

    Clinical Neuroscience   2007.11

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 概日リズムとがんの時間薬物治療

    小柳 悟

    Clinical Neuroscience   2007.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • インターフェロンの時間薬理学的研究

    大戸茂弘, 小柳 悟

    臨床薬理の進歩   2004.8

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 血管内皮増殖因子の発現リズムを指標にした血管新生阻害薬の至適投薬タイミング設定

    小柳 悟, 大戸茂弘, 添田秦司, 占野廣司

    臨床薬理の進歩   2004.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体リズムを基盤にした医薬品の適正使用に関する臨床生化学的研究

    小柳 悟

    薬学雑誌   2003.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 時間薬理学:生体リズムを考慮した薬物療法

    小柳 悟, 大戸茂弘, 高根 浩, 樋口 駿

    Clinical Neuroscience   1999.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Industrial property rights

Patent   Number of applications: 2   Number of registrations: 1
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本薬学会

  • 日本薬物動態学会

  • The Japanese Society for Alternatives to Animal Experiments

  • 日本薬剤学会

  • 日本臨床薬理学会

  • The Japanese Pharmacological Society

  • 日本毒性学会

  • 日本時間生物学会

▼display all

Committee Memberships

  • 日本薬物動態学会   Steering committee member   Domestic

    2024.1 - 2025.12   

  • 日本薬物動態学会   代議員   Domestic

    2024.1 - 2025.12   

  • 日本時間生物学会   Councilor   Domestic

    2011.4 - 2022.11   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • Screening of academic papers

    Role(s): Peer review

    2023

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

  • プログラム委員

    日本薬物動態学会第37回年会  ( Japan ) 2022.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:700

  • 運営委員/プログラム委員

    第27回日本時間生物学会学術大会  ( Japan ) 2021.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:300

  • プログラム委員

    日本薬物動態学会第36回年会  ( Japan ) 2021.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:700

  • Screening of academic papers

    Role(s): Peer review

    2021

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • 事務局長・運営委員

    第41回日本臨床薬理学会学術総会  ( Japan ) 2020.12

     More details

    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 運営委員

    日本薬剤学会 第35回年会  ( Japan ) 2020.5

     More details

    Type:Competition, symposium, etc. 

    Number of participants:1,000

  • Screening of academic papers

    Role(s): Peer review

    2020

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:17

  • シンポジウム オーガナイザー・座長

    日本薬物動態学会第34回年会  ( Japan ) 2019.12

     More details

    Type:Competition, symposium, etc. 

    Number of participants:150

  • シンポジウム オーガナイザー・座長

    第92回日本薬理学会学術大会  ( Japan ) 2019.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • Screening of academic papers

    Role(s): Peer review

    2019

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • 大会組織委員

    第25回日本時間生物学会学術大会  ( Japan ) 2018.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:300

  • シンポジウム オーガナイザー・座長

    第25回日本時間生物学会学術大会  ( Japan ) 2018.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:300

  • Screening of academic papers

    Role(s): Peer review

    2018

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

    Number of peer-reviewed articles in Japanese journals:1

  • シンポジウム オーガナイザー・座長

    医療薬学フォーラム2017 第25回クリニカルファーマシーシンポジウム  ( Japan ) 2017.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:1,500

  • Screening of academic papers

    Role(s): Peer review

    2017

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

    Number of peer-reviewed articles in Japanese journals:2

  • 事務局長

    日本動物実験代替法学会 第28回大会  ( Japan ) 2016.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • シンポジウム オーガナイザー・座長 International contribution

    日本動物実験代替法学会 第28回大会  ( Japan ) 2016.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:500

  • 日本時間生物学会会誌

    2016.4 - Present

     More details

    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2016

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:95

  • 組織委員 International contribution

    The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics  ( Japan ) 2015.10 - 2016.6

     More details

    Type:Competition, symposium, etc. 

    Number of participants:180

  • Screening of academic papers

    Role(s): Peer review

    2015

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Number of peer-reviewed articles in Japanese journals:2

  • 事務局長

    第21回日本時間生物学会学術大会  ( Japan ) 2014.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:300

  • Screening of academic papers

    Role(s): Peer review

    2014

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:120

  • 組織委員(学会事務局長)

    医療薬学フォーラム2012/第20回クリニカルファーマシーシンポジム  ( Japan ) 2012.7

     More details

    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 開催事務局

    第3回次世代を担う若手医療薬科学シンポジウム  ( Japan ) 2009.11

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

▼display all

Research Projects

  • 脊髄に浸潤する免疫担当細胞に着目した神経障害性疼痛の性差の解明

    Grant number:25K02425  2025 - 2027

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • RNA編集の時刻変動を基軸にした時間薬剤学研究

    2023

    上原記念生命科学財団

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • カイコ昆⾍モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022.12 - 2026.4

      More details

    Authorship:Coinvestigator(s) 

  • グリーンファルマ創薬構造解析による支援高度化の推進

    2022.11 - 2026.4

      More details

    Authorship:Coinvestigator(s) 

  • 細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究

    Grant number:22H00442  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    大戸 茂弘, 松永 直哉, 小柳 悟

      More details

    Grant type:Scientific research funding

    体内時計は全身の細胞に発現する時計遺伝子により制御されるが、その中枢は脳の視交叉上核 (SCN)に位置し、神経伝達や液性伝達を介して末梢臓器機能のリズムを制御することで、薬物に対する生体反応の投薬時刻の差異が生じることを世界に先駆けて証明してきた。さらなる解析の結果、薬物の感受性に新たな時計(細胞伝達時計)が関与することを突き止めた。細胞伝達時計は、末梢血中に存在する単球などの血球系細胞が、血管を介し各臓器へ運搬され浸潤した臓器の時計を制御する新たな体内時計機構の一つと考えている。そこで本研究では、体内時計調節機構としての細胞伝達時計の機能を解析して生理学的意義を明らかにする。

    CiNii Research

  • Exploration of analgesic drug based on the underlying mechanism of circadian variation in the cancer breakthrough pain

    Grant number:22K18375  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Pioneering)

    小柳 悟

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    がんによる疼痛には持続的に続く「慢性痛」と、突然の激しい痛みに襲われる「突発痛」が認められるが、がん末期に発症する突発痛に対してはオピオイドなども奏功し難いことから、より有効な鎮痛薬の開発が求められている。がんによる疼痛は一日の中の特定の時間帯に頻発することから、この点に着目して探索を行い、疼痛が頻発する時間帯に脊髄内で発現が上昇する短鎖ペプチドを発見した。本研究では概日変動を考慮したがん疼痛の評価法を用いて、その発症におけるこれら短鎖ペプチドの役割と鎮痛標的分子としての評価を行う。また、遺伝子創薬データベースを用いてがん突発痛に対する効率的かつ経済的な治療薬の探索を目指す。

    CiNii Research

  • 時計遺伝子の機能不全による「がん幹細胞」発生機序の解明と抗がん剤耐性克服法の開発

    Grant number:20K21484  2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Exploratory)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新規経皮吸収型製剤を目指した鎮痛薬に関する研究

    2018.7 - 2019.7

    Joint research

      More details

    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • RNA編集と概日リズム制御機構との統合解析による薬物体内動態の個体差要因の解明

    Grant number:18H04019  2018 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 薬物動態の日内変動に関する研究

    2017.4 - 2019.3

    Joint research

      More details

    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • グリーンファルマを基盤にした創薬オープンイノベーションの推進

    2017 - 2021

    日本医療研究開発機構 「薬等ライフサイエンス研究支援基盤事業」

      More details

    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 足場タンパクに着目した薬物輸送トランスポーターの細胞膜局在における概日リズム制御

    Grant number:17K19493  2017 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Exploratory)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の分子機構を介した薬物代謝酵素CYP3A4の活性個人差の究明

    2017 - 2018

    内藤記念科学奨励金・研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 副腎皮質ホルモン作動性因子による神経障害痛の概日リズム制御と鎮痛標的としての評価

    Grant number:15H04765  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の機能強化によるがん予防法の開発

    Grant number:26670317  2014 - 2015

    Grants-in-Aid for Scientific Research  Grant-in-Aid for challenging Exploratory Research

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • Establishment of in vitro circadian clock system for evaluation of cell protecting mechanism against oncogenic transformation

    2013 - 2014

    The 6th Mandom International Research Grants on Alternative to Animal Experiments

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 難治性がん疼痛の概日変動メカニズムを基盤にした鎮痛標的分子の探索

    Grant number:24390149  2012 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の活性化による成人性疾患の予防・治療法の開発

    Grant number:24650446  2012 - 2013

    Grants-in-Aid for Scientific Research  Grant-in-Aid for challenging Exploratory Research

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • Effect of Brand’s Essence of Chicken on the mammalian circadian system

    2009.10 - 2013.1

    Research commissions

      More details

    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 分子時計を標的にした抗がん剤耐性克服法の開発

    2009 - 2010

    中冨健康科学振興財団 研究助成金

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 抗リウマチ薬の時間薬物療法の確立

    2008 - 2010

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 血清成分を指標にした抗がん剤の時間治療の構築

    2008

    薬理研究会助成金

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 時計遺伝子を指標にしたCYP3A4の活性予測

    2007 - 2008

    臨床薬理研究振興財団研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 腫瘍細胞動態の日内変動を考慮した抗がん薬の至適投薬タイミング設定法の構築

    2003

    上原生命科学財団研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • がん病態の日内変動に着目した抗腫瘍薬の時間薬物療法の構築

    2002

    武田科学研究振興財団 薬学奨励研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 血清中因子を指標にした血管新生阻害薬の至適投薬タイミング設定

    2001

    臨床薬理研究振興財団研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

▼display all

Educational Activities

  • 大学院教育(薬学府)
      薬剤・動態学
      薬学総論 I (創薬・育薬)
      医療薬学研究英語講義
      臨床研究演習
      臨床試験演習
      先端研究実験 I
      先端研究実験 II
      先端研究演習 I
      先端研究演習 II
      先端研究演習 II

    学部教育(薬学部)
      薬剤学I
      薬剤学II
      免疫学A
      免疫学B
      科学論文総合演習II
      医療薬学実習IV
      実務実習プレ演習

    基幹教育
     創薬科学総論

Class subject

  • 臨床試験演習

    2025.10 - 2026.3   Second semester

  • 医療薬学実習IV(分担)

    2025.10 - 2026.3   Second semester

  • 実務実習プレ演習

    2025.10 - 2026.3   Second semester

  • 臨床研究演習

    2025.10 - 2026.3   Second semester

  • 薬剤学Ⅱ

    2025.10 - 2025.12   Fall quarter

  • 免疫学B

    2025.10 - 2025.12   Fall quarter

  • 医療薬学研究

    2025.10 - 2025.12   Fall quarter

  • 少人数セミナー(分担)

    2025.6 - 2025.8   Summer quarter

  • 免疫学A

    2025.6 - 2025.8   Summer quarter

  • 薬学基礎実習Ⅳ

    2025.6 - 2025.8   Summer quarter

  • 高度融合研究実験

    2025.4 - 2026.3   Full year

  • 高度融合研究演習 I

    2025.4 - 2026.3   Full year

  • 高度融合研究演習 II

    2025.4 - 2026.3   Full year

  • 先端研究指導実習

    2025.4 - 2026.3   Full year

  • 先端医療薬学研究実験

    2025.4 - 2026.3   Full year

  • 先端医療薬学研究演習 I

    2025.4 - 2026.3   Full year

  • 先端医療薬学研究演習 II

    2025.4 - 2026.3   Full year

  • 先端医療薬学研究演習 III

    2025.4 - 2026.3   Full year

  • 先端研究実験I

    2025.4 - 2026.3   Full year

  • 先端研究実験II

    2025.4 - 2026.3   Full year

  • 医療薬学系英語講義

    2025.4 - 2026.3   Full year

  • 専門英語

    2025.4 - 2026.3   Full year

  • 卒業研究

    2025.4 - 2026.3   Full year

  • 医療薬学研究 英語講義

    2025.4 - 2026.3   Full year

  • 医療薬学演習 II

    2025.4 - 2025.9   First semester

  • 医療薬学演習 I

    2025.4 - 2025.9   First semester

  • 薬学総論Ⅰ

    2025.4 - 2025.6   Spring quarter

  • 創薬科学総論 I

    2025.4 - 2025.6   Spring quarter

  • 薬物動態学ⅠA

    2025.4 - 2025.6   Spring quarter

  • 薬剤学Ⅰ

    2025.4 - 2025.6   Spring quarter

  • 薬剤・動態学

    2025.4 - 2025.6   Spring quarter

  • 臨床研究演習

    2024.10 - 2025.3   Second semester

  • 実務実習プレ演習

    2024.10 - 2025.3   Second semester

  • 医療薬学実習IV(分担)

    2024.10 - 2025.3   Second semester

  • 臨床試験演習

    2024.10 - 2025.3   Second semester

  • 医療薬学研究

    2024.10 - 2024.12   Fall quarter

  • 免疫学B

    2024.10 - 2024.12   Fall quarter

  • 薬剤学Ⅱ

    2024.10 - 2024.12   Fall quarter

  • 薬物動態学ⅠB

    2024.6 - 2024.8   Summer quarter

  • 薬学基礎実習Ⅳ

    2024.6 - 2024.8   Summer quarter

  • 免疫学A

    2024.6 - 2024.8   Summer quarter

  • 薬物動態学ⅠB

    2024.6 - 2024.8   Summer quarter

  • 少人数セミナー(分担)

    2024.6 - 2024.8   Summer quarter

  • 医療薬学研究 英語講義

    2024.4 - 2025.3   Full year

  • 卒業研究

    2024.4 - 2025.3   Full year

  • 専門英語

    2024.4 - 2025.3   Full year

  • 医療薬学系英語講義

    2024.4 - 2025.3   Full year

  • 先端研究実験II

    2024.4 - 2025.3   Full year

  • 先端研究実験I

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 III

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 II

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 I

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究実験

    2024.4 - 2025.3   Full year

  • 先端研究指導実習

    2024.4 - 2025.3   Full year

  • 高度融合研究演習 II

    2024.4 - 2025.3   Full year

  • 高度融合研究演習 I

    2024.4 - 2025.3   Full year

  • 高度融合研究実験

    2024.4 - 2025.3   Full year

  • 医療薬学演習 I

    2024.4 - 2024.9   First semester

  • 医療薬学演習 II

    2024.4 - 2024.9   First semester

  • 薬剤・動態学

    2024.4 - 2024.6   Spring quarter

  • 薬剤学Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 薬物動態学ⅠA

    2024.4 - 2024.6   Spring quarter

  • 創薬科学総論 I

    2024.4 - 2024.6   Spring quarter

  • 薬学総論Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 実務実習プレ演習

    2023.10 - 2024.3   Second semester

  • 臨床研究演習

    2023.10 - 2024.3   Second semester

  • 臨床試験演習

    2023.10 - 2024.3   Second semester

  • 医療薬学実習IV(分担)

    2023.10 - 2024.3   Second semester

  • 薬剤学Ⅱ

    2023.10 - 2023.12   Fall quarter

  • 薬剤学Ⅱ

    2023.10 - 2023.12   Fall quarter

  • 医療薬学研究

    2023.10 - 2023.12   Fall quarter

  • 免疫学B

    2023.10 - 2023.12   Fall quarter

  • 医療薬学研究

    2023.10 - 2023.12   Fall quarter

  • 少人数セミナー(分担)

    2023.6 - 2023.8   Summer quarter

  • 薬物動態学ⅠB

    2023.6 - 2023.8   Summer quarter

  • 免疫学A

    2023.6 - 2023.8   Summer quarter

  • 薬物送達システム学

    2023.6 - 2023.8   Summer quarter

  • 薬物動態学ⅠB

    2023.6 - 2023.8   Summer quarter

  • 卒業研究

    2023.4 - 2024.3   Full year

  • 医療薬学研究 英語講義

    2023.4 - 2024.3   Full year

  • 高度融合研究実験

    2023.4 - 2024.3   Full year

  • 高度融合研究演習 I

    2023.4 - 2024.3   Full year

  • 高度融合研究演習 II

    2023.4 - 2024.3   Full year

  • 先端研究指導実習

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究実験

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 I

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 II

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 III

    2023.4 - 2024.3   Full year

  • 先端研究実験I

    2023.4 - 2024.3   Full year

  • 先端研究実験II

    2023.4 - 2024.3   Full year

  • 医療薬学系英語講義

    2023.4 - 2024.3   Full year

  • 専門英語

    2023.4 - 2024.3   Full year

  • 医療薬学演習 II

    2023.4 - 2023.9   First semester

  • 医療薬学演習 I

    2023.4 - 2023.9   First semester

  • 創薬科学総論 I

    2023.4 - 2023.6   Spring quarter

  • 薬物動態学ⅠA

    2023.4 - 2023.6   Spring quarter

  • 薬学総論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 薬剤・動態学

    2023.4 - 2023.6   Spring quarter

  • 薬剤・動態学

    2023.4 - 2023.6   Spring quarter

  • 薬学総論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 臨床試験演習

    2022.10 - 2023.3   Second semester

  • 医療薬学実習IV(分担)

    2022.10 - 2023.3   Second semester

  • 臨床研究演習

    2022.10 - 2023.3   Second semester

  • 医療薬学研究

    2022.10 - 2022.12   Fall quarter

  • 薬剤学Ⅱ

    2022.10 - 2022.12   Fall quarter

  • 薬物動態学ⅠB

    2022.6 - 2022.8   Summer quarter

  • 少人数セミナー(分担)

    2022.6 - 2022.8   Summer quarter

  • 先端研究実験I

    2022.4 - 2023.3   Full year

  • 専門英語

    2022.4 - 2023.3   Full year

  • 実務実習プレ演習

    2022.4 - 2023.3   Full year

  • 卒業研究

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 III

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 II

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 I

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究実験

    2022.4 - 2023.3   Full year

  • 先端研究指導実習

    2022.4 - 2023.3   Full year

  • 高度融合研究演習 II

    2022.4 - 2023.3   Full year

  • 高度融合研究演習 I

    2022.4 - 2023.3   Full year

  • 高度融合研究実験

    2022.4 - 2023.3   Full year

  • 医療薬学系英語講義

    2022.4 - 2023.3   Full year

  • 医療薬学研究 英語講義

    2022.4 - 2023.3   Full year

  • 先端研究実験II

    2022.4 - 2023.3   Full year

  • 医療薬学演習 I

    2022.4 - 2022.9   First semester

  • 医療薬学演習 II

    2022.4 - 2022.9   First semester

  • 薬剤・動態学

    2022.4 - 2022.6   Spring quarter

  • 創薬科学総論 I

    2022.4 - 2022.6   Spring quarter

  • 薬物動態学ⅠA

    2022.4 - 2022.6   Spring quarter

  • 薬学総論Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 臨床試験演習

    2021.10 - 2022.3   Second semester

  • 医療薬学実習IV(分担)

    2021.10 - 2022.3   Second semester

  • 臨床研究演習

    2021.10 - 2022.3   Second semester

  • 薬剤学Ⅱ

    2021.10 - 2021.12   Fall quarter

  • 少人数セミナー(分担)

    2021.10 - 2021.12   Fall quarter

  • 先端研究実験I

    2021.4 - 2022.3   Full year

  • 専門英語

    2021.4 - 2022.3   Full year

  • 薬学特別実習

    2021.4 - 2022.3   Full year

  • 実務実習プレ演習

    2021.4 - 2022.3   Full year

  • アドバンスト実務実習

    2021.4 - 2022.3   Full year

  • 卒業研究

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 III

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 II

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 I

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究実験

    2021.4 - 2022.3   Full year

  • 先端研究指導実習

    2021.4 - 2022.3   Full year

  • 高度融合研究演習 II

    2021.4 - 2022.3   Full year

  • 高度融合研究演習 I

    2021.4 - 2022.3   Full year

  • 高度融合研究実験

    2021.4 - 2022.3   Full year

  • 医療薬学系英語講義

    2021.4 - 2022.3   Full year

  • 医療薬学研究 英語講義

    2021.4 - 2022.3   Full year

  • 先端研究実験II

    2021.4 - 2022.3   Full year

  • 医療薬学演習 I

    2021.4 - 2021.9   First semester

  • 医療薬学演習 II

    2021.4 - 2021.9   First semester

  • 薬剤・動態学

    2021.4 - 2021.6   Spring quarter

  • 創薬科学総論 I

    2021.4 - 2021.6   Spring quarter

  • 薬学総論 I

    2021.4 - 2021.6   Spring quarter

  • 医療薬学実習IV(分担)

    2020.10 - 2021.3   Second semester

  • 臨床試験演習

    2020.10 - 2021.3   Second semester

  • 少人数セミナー(分担)

    2020.10 - 2020.12   Fall quarter

  • 薬剤学Ⅱ

    2020.10 - 2020.12   Fall quarter

  • 医療薬学系英語講義

    2020.4 - 2021.3   Full year

  • 先端研究指導実習

    2020.4 - 2021.3   Full year

  • 卒業研究

    2020.4 - 2021.3   Full year

  • アドバンスト実務実習

    2020.4 - 2021.3   Full year

  • 実務実習プレ演習

    2020.4 - 2021.3   Full year

  • 薬学特別実習

    2020.4 - 2021.3   Full year

  • 先端研究実験II

    2020.4 - 2021.3   Full year

  • 臨床研究演習

    2020.4 - 2021.3   Full year

  • 医療薬学研究 英語講義

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究実験

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 I

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 II

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 III

    2020.4 - 2021.3   Full year

  • 高度融合研究実験

    2020.4 - 2021.3   Full year

  • 高度融合研究演習 I

    2020.4 - 2021.3   Full year

  • 高度融合研究演習 II

    2020.4 - 2020.9   First semester

  • 先端研究実験I

    2020.4 - 2020.9   First semester

  • 医療薬学演習 I

    2020.4 - 2020.9   First semester

  • 医療薬学演習 II

    2020.4 - 2020.9   First semester

  • 創薬科学総論 I

    2020.4 - 2020.6   Spring quarter

  • 薬学総論 I

    2020.4 - 2020.6   Spring quarter

  • 薬剤・動態学

    2020.4 - 2020.6   Spring quarter

  • 医療薬学実習IV(分担)

    2019.10 - 2020.3   Second semester

  • 薬剤学Ⅱ

    2019.10 - 2019.12   Fall quarter

  • 少人数セミナー(分担)

    2019.10 - 2019.12   Fall quarter

  • 先端研究実験I

    2019.4 - 2020.3   Full year

  • 薬学特別実習

    2019.4 - 2020.3   Full year

  • 実務実習プレ演習

    2019.4 - 2020.3   Full year

  • アドバンスト実務実習

    2019.4 - 2020.3   Full year

  • 卒業研究

    2019.4 - 2020.3   Full year

  • 医療薬学系英語講義

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 III

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 II

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 I

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究実験

    2019.4 - 2020.3   Full year

  • 先端研究指導実習

    2019.4 - 2020.3   Full year

  • 高度融合研究演習 II

    2019.4 - 2020.3   Full year

  • 高度融合研究演習 I

    2019.4 - 2020.3   Full year

  • 高度融合研究実験

    2019.4 - 2020.3   Full year

  • 医療薬学研究 英語講義

    2019.4 - 2020.3   Full year

  • 先端研究実験II

    2019.4 - 2020.3   Full year

  • 医療薬学演習 I

    2019.4 - 2019.9   First semester

  • 医療薬学演習 II

    2019.4 - 2019.9   First semester

  • 薬剤・動態学

    2019.4 - 2019.6   Spring quarter

  • 創薬科学総論 I

    2019.4 - 2019.6   Spring quarter

  • 医療薬学実習IV(分担)

    2018.10 - 2019.3   Second semester

  • 薬剤学Ⅱ

    2018.10 - 2018.12   Fall quarter

  • 少人数セミナー(分担)

    2018.10 - 2018.12   Fall quarter

  • 先端研究実験I

    2018.4 - 2019.3   Full year

  • 薬学特別実習

    2018.4 - 2019.3   Full year

  • 実務実習プレ演習

    2018.4 - 2019.3   Full year

  • アドバンスト実務実習

    2018.4 - 2019.3   Full year

  • 卒業研究

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 III

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 II

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 I

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究実験

    2018.4 - 2019.3   Full year

  • 先端研究指導実習

    2018.4 - 2019.3   Full year

  • 高度融合研究演習 II

    2018.4 - 2019.3   Full year

  • 高度融合研究演習 I

    2018.4 - 2019.3   Full year

  • 高度融合研究実験

    2018.4 - 2019.3   Full year

  • 医療薬学研究 英語講義

    2018.4 - 2019.3   Full year

  • 先端研究実験II

    2018.4 - 2019.3   Full year

  • 医療薬学演習 I

    2018.4 - 2018.9   First semester

  • 医療薬学演習 II

    2018.4 - 2018.9   First semester

  • 薬剤・動態学

    2018.4 - 2018.6   Spring quarter

  • 創薬科学総論 I

    2018.4 - 2018.6   Spring quarter

▼display all

FD Participation

  • 2024.9   Role:Participation   Title:薬物依存対策研修会

    Organizer:University-wide

  • 2024.7   Role:Participation   Title:第5回創薬産学官連携セミナー(新モダリティ)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.11   Role:Participation   Title:機関間連携

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.11   Role:Participation   Title:令和5年度4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.3   Role:Participation   Title:第4回全学FD(TF 経験を通じて大学院生の教育能力を高める)

    Organizer:University-wide

  • 2022.11   Role:Participation   Title:アカデミア創薬

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role:Participation   Title:学生の多様性に対応した教育とは:障害学生への合理的配慮を中心に

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Role:Participation   Title:未来を拓く博士人材育成のためのオープンプラットフォーム型教育システムの構築

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.3   Role:Participation   Title:3ポリシーの見直し指針について

    Organizer:University-wide

  • 2018.10   Role:Participation   Title:平成30年度馬出地区4部局合同男女共同参画FD

    Organizer:University-wide

  • 2017.3   Role:Planning   Title:九州大学における情報セキュリティに関する取組

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.10   Role:Participation   Title:馬出地区キャンパスFD —男女共同参画の必要性と九州大学における取組み—

    Organizer:University-wide

  • 2016.5   Role:Participation   Title:外国人留学生の受入と管理(情報管理、輸出管理)について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.4   Role:Participation   Title:Webを用いた薬局実務実習記録書(電子ポートフォリオ)に関する説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.6   Role:Participation   Title:製薬業界の環境変化を受けた今後のMR活動とメディカルアフェアーズの確立について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.8   Role:Participation   Title:GPA制度を正しく活用して、教育の質向上を図る

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.3   Role:Participation   Title:学生のメンタルヘルスの現状と対応

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.4   Role:Participation   Title:薬局実習実施説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.10   Role:Participation   Title:OSCE評価者説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.5   Role:Participation   Title:第1 回 全学FD

    Organizer:University-wide

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2023  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2022  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2022  徳島大学・ 薬学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(1月)

  • 2021  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2020  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2019  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2018  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2017  千葉大学大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(5月)

  • 2015  熊本大学大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(1月)

  • 2015  早稲田大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2015  千葉大学大学院医学薬学府  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(5月)

  • 2013  富山大学医学薬学教育部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(平成25年4月〜平成25年9月)

▼display all

Participation in international educational events, etc.

  • 2025.9

    北海道大学 薬学部(台湾)

    日本-台湾 薬学部 6大学ジョイントシンポジウム

      More details

    Venue:札幌市

    Number of participants:200

  • 2024.9

    長崎大学 薬学部(台湾)

    日本-台湾 薬学部 6大学ジョイントシンポジウム

      More details

    Venue:長崎市

    Number of participants:200

  • 2023.9

    陽明交通大学 薬学部(台湾)

    日本-台湾 薬学部 6大学ジョイントシンポジウム

      More details

    Venue:台北市

    Number of participants:200

  • 2020.9

    九州大学大学院薬学研究院

    ASIA WEEK2020(薬学国際ウェビナー)

      More details

    Number of participants:40

Other educational activity and Special note

  • 2022  Special Affairs  ウィズコロナ時代の新たな医療に対応できる医療人材養成事業

     詳細を見る

    ウィズコロナ時代の新たな医療に対応できる医療人材養成事業

  • 2022  Special Affairs  薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

  • 2021  Special Affairs  薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

  • 2021  Special Affairs  オンライン・ハイブリット講義の実施に向けた部局内プラットホームの構築

     詳細を見る

    オンライン・ハイブリット講義の実施に向けた部局内プラットホームの構築

  • 2020  Special Affairs  薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(実施責任者)、薬学OSCE(ステーション責任者)

  • 2019  Special Affairs  薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

  • 2018  Class Teacher  学部

  • 2018  Special Affairs  薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

  • 2017  Special Affairs  薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

  • 2016  Special Affairs  薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

     詳細を見る

    薬学CBT(システム管理責任者)、薬学OSCE(ステーション責任者)

▼display all

Outline of Social Contribution and International Cooperation activities

  • 福岡地区勤務薬剤会 生涯教育委員会

Social Activities

  • 体内時計を活用した創薬研究と疾患治療

    山口県立徳山高等学校  2024.3

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計と健康・病気のリズム

    福岡市薬剤師会  福岡市薬剤師会館  2024.1

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Cardinal training 「添付文書から薬の特徴・薬物動態を知る」

    福岡市薬剤師会  福岡市薬剤師会館  2022.3

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 平成21年度明善高校大学セミナー

    福岡県立明善高等学校  2021.6

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 身体のリズムと薬物治療

    福岡市薬剤師会  福岡市薬剤師会館  2021.3

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 身体のリズムと がん・慢性疼痛の薬物治療

    福岡市薬剤師会  福岡市薬剤師会館  2019.11

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 九州大学について

    福岡県立鞍手高等学校  2019.3

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 社会における薬学研究の役割

    明治学園高校・中学校  2018.7

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計研究の進展と医療・創薬への応用

    平成27年度九州大学薬学研究院公開講座  九州大学コラボステーション  2017.6

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 平成23年度明善高校大学セミナー

    福岡県立明善高等学校  2011.12

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 平成22年度明善高校大学セミナー:薬学部6年制と4年制学科の現状と今後について

    福岡県立明善高等学校  2010.12

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • TDMセミナー(抗がん剤、免疫抑制剤のTDM)

    福岡地区勤務薬剤師会  イムズホール  2010.10

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 濟々未来講座:薬学部4年制と6年制の現状と今後

    熊本県立濟々黌高等学校  2010.10

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計と薬の効果・毒性のリズム

    身近な毒に強くなる会  九州大学西新交流プラザ  2010.9

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 時計遺伝子のはたらきと薬の効果のリズム

    平成22年度九州大学薬学研究院公開講座  九州大学コラボステーション  2010.8

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九州大学薬学部の創薬科学科と臨床薬学科について

    熊本県立熊本高等学校  2010.6

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学薬学部の4年制と6年制の学科について

    熊本県立濟々黌高等学校  2010.6

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 新型インフルエンザのパンデミックは起こり得るのか?

    身近な毒に強くなる会  九州大学西新交流プラザ  2009.2

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Basic Study研修会 ホルモン全般について(2)

    福岡市薬剤師会  福岡市薬剤師会館  2008.4

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Basic Study研修会 ホルモン全般について(1)

    福岡市薬剤師会  福岡市薬剤師会館  2008.3

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • リン酸オセミタビルの効果と副作用について

    身近な毒に強くなる会  九州大学西新交流プラザ  2007.8

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 体内時計の働きと病気のリズム

    東明館高校  2007.6

     More details

    Audience:Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 時間治療 〜体内時計の働きと疾患・薬効のリズム〜

    臨床薬理学会  大分県・別府市  2005.12

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 体内時計の分子機構を基盤にしたガンの時間治療

    大阪薬科大学  大阪府・高槻市  2005.12

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 体内時計の働きと病気のリズム

    福岡大学  福岡市  2002.5

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

▼display all

Media Coverage

  • 薬をのむ「最適時間」がわかった Newspaper, magazine

    文芸春秋  2017.10

     More details

    薬をのむ「最適時間」がわかった

  • 神経障害性疼痛 痛みの強さ時間帯で変化 仕組み解明 TV or radio program

    NHKニュース  2016.10

     More details

    神経障害性疼痛 痛みの強さ時間帯で変化 仕組み解明

  • 時間帯で痛み変化 九大が仕組み解明 Newspaper, magazine

    読売新聞  2016.10

     More details

    時間帯で痛み変化 九大が仕組み解明

  • 神経性の痛み 時刻で変化 〜九大チーム、仕組み解明〜 Newspaper, magazine

    朝日新聞  2016.10

     More details

    神経性の痛み 時刻で変化 〜九大チーム、仕組み解明〜

  • 「からだの時計」が医療を変える TV or radio program

    NHK総合テレビ「クローズアップ現代」  2012.4

     More details

    「からだの時計」が医療を変える

  • 不明 Newspaper, magazine

    AERA  2005.6

  • 薬を飲む時間に要注意!知られざる生体リズムとの関係 TV or radio program

    NHK教育テレビ「サイエンスアイ」  1998.5

     More details

    薬を飲む時間に要注意!知られざる生体リズムとの関係

▼display all

Acceptance of Foreign Researchers, etc.

  • 台北医学大学

    Acceptance period: 2019.1 - 2019.2   (Period):2weeks to less than 1 month

    Nationality:Taiwan, Province of China

    Business entity:On-campus funds

  • Chulalongkorn University

    Acceptance period: 2018.6 - 2018.7   (Period):2weeks to less than 1 month

    Nationality:Thailand

    Business entity:On-campus funds

Travel Abroad

  • 2019.4

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:國立陽明大學

  • 2019.4

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:台北医学大学

  • 2018.9

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:台北医学大学

  • 2018.1

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:Taipei Medical University