Updated on 2024/07/28

Information

 

写真a

 
SATORU KOYANAGI
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Professor
Research Center for Education in Health Care System (Joint Appointment)
Kyushu University Hospital Pharmacy(Joint Appointment)
School of Pharmaceutical Sciences Department of Clinical Pharmacy(Joint Appointment)
Graduate School of Pharmaceutical Sciences Department of Clinical Pharmacy(Joint Appointment)
Graduate School of Pharmaceutical Sciences Department of Medicinal Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426611
Profile
Recent developments in our understanding of circadian biology and the availability of tools to characterize this oscillation system indicate that the choosing appropriate dosing time have consequences for the ef cacy and safety of new and existing therapeutic drugs (Chronopharmacotherapy). Progression of this research eld also suggests that many pathological conditions are under the control of the circadian clock. These notions reveal opportunities for new therapeutic strategies. Now novel therapeutic approaches are facilitated by development of chemical probes and synthetic ligands targeted to an increasing number of the key proteins that causing circadian exacerbation of pathological events. The major objective of our research is to understand the molecular mechanisms for day-night changes in the pathological events and the impact of circadian rhythms on the onset of diseases. Based on these mechanism, we attempt to identify new therapeutic target and to develop novel strategy for treatment of diseases.
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Degree

  • Ph.D

Research Interests・Research Keywords

  • Research theme:Investigation of underlying mechanism of circadian variations in the function of pharmacokinetic regulatory factor by RNA editting

    Keyword:RNA editting, pharmacokinetic regulatory factor, circadian rhythm

    Research period: 2018.4 - 2024.3

  • Research theme:Study on the role of circadian clock gene in the oncogenic transformation

    Keyword:Clock genes, Cellular oncogenic transformation

    Research period: 2011.4

  • Research theme:Study on the mechanism for circadian regulation of intractable pain

    Keyword:Neuropathic pain , Cancer, Circadian rhythm

    Research period: 2010.4

  • Research theme:Development of chronopharmacotherapy of anti-cancer drug based on molecular circadian clock

    Keyword:Biological rhythm, clock gene, cell cycle

    Research period: 2005.12 - 2011.3

  • Research theme:Evaluation of the mechanism of circadian time-dependent change of drug efficacy and development of chronodrug delivery system

    Keyword:target molecule, drug metabolism, transporter

    Research period: 2005.12

Awards

  • 2021年度 日本薬学会 学術振興賞

    2021.3   日本薬学会   病態・薬効の概日変動メカニズムを基盤にした時間薬剤学研究

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    2021年3月に「病態・薬効の概日変動メカニズムを基盤にした時間薬剤学研究」のタイトルにて、日本薬学会学術振興賞を受賞した。

  • 平成25年度日本薬物動態学会奨励

    2013.10   日本薬物動態学会   時計遺伝子を基盤にした薬物動態制御因子の概日変動メカニズムに関する研究

  • 第6回 日本時間生物学会学術奨励賞

    2008.11   日本時間生物学会   体内時計の分子機構を基盤にした抗癌剤の創薬・育薬研究

  • 日本薬学会九州支部学術奨励賞受賞

    2002.12   日本薬学会九州支部   受賞研究題名:生体リズムを考慮した医薬品の適正使用に関する臨床生化学的研究

Papers

  • Suppression of neuropathic pain in the circadian clock-deficient Per2m/m mice involves up-regulation of endocannabinoid system Invited Reviewed International journal

    Yamakawa W, Yasukochi S, Tsurudome Y, Kusunose N, Yamaguchi Y, Tsuruta A, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S

    PNAS Nexus   3   pgad483   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/pnasnexus/pgad482

  • RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells Reviewed International journal

    Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S

    J Biol Chem   298   102184   2022.7

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  • RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene Reviewed International journal

    Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S

    J Biol Chem   298   100601   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100601

  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed International journal

    Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S

    Nature Commun.   7   2016.10

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  • Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation Reviewed International journal

    Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S

    J Biol Chem   291   2016.5

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  • Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells Reviewed International journal

    Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.

    Cancer Res   8   2013.4

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  • Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway Reviewed International journal

    Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.

    J Biol Chem   21 ( 17224-17231 )   2012.5

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  • Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors Reviewed International journal

    Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.

    Cancer Res.   72 ( 395-401 )   2011.11

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  • cAMP response element-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. Reviewed International journal

    Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S.

    J Biol Chem.   286 ( 32416-32423 )   2011.7

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  • Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice Reviewed International journal

    Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S

    Gastroenterology   135 ( 1636-1644 )   2008.8

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  • Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells Reviewed International journal

    Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Koyanagi S., and Ohdo S.

    Pharmacogenet. Genomics   17 ( 1047-1056 )   2007.12

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  • A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells Reviewed International journal

    Koyanagi S., Kuramoto Y., Nakagawa H., Aramaki H., Ohdo S., Soeda S., Shimeno H.

    Cancer Res.   21 ( 7277-7283 )   2003.11

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  • Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Reviewed International journal

    Ohdo S., Koyanagi S., Suyama H., Higuchi S., Aramaki H.

    Nature Medicine   3 ( 354-360 )   2001.3

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  • Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins Reviewed International journal

    3. Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Pharmacol   215   15708   2023.7

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    DOI: 10.1016/j.bcp.2023.115708

  • Inhibition of tumor-derived C-C motif chemokine ligand 2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice Reviewed International journal

    Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T, Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S

    Mol Pharmacol   104   73 - 79   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/molpharm.123.000690

  • The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells Reviewed International journal

    Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.

    J Biochem   2023.5

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    DOI: 10.1093/jb/mvad035

  • Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19 Reviewed International journal

    Hashikawa KI, Tsuruta A, Yamakawa W, Yasukochi S, Koyanagi S, Ohdo S.

    Biochem Biophys Res Commun   2023.4

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  • Fluorescence-based detection of fatty acid β-oxidation in cells and tissues using quinone methide-releasing probes Reviewed International journal

    2023.4

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  • Omeprazole suppresses oxaliplatin-induced peripheral neuropathy in a rodent model and clinical database Reviewed International journal

    Mine K, Kawashiri T, Inoue M, Kobayashi D, Mori K, Hiromoto S, Kudamatsu H, Uchida M, Egashira N, Koyanagi S, Ohdo S, Shimazoe T

    Int J Mol Sci   23   8859   2022.4

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  • Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice Invited Reviewed International journal

    Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S.

    Mol Cancer Res   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1541-7786.MCR-21-0786

  • Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells Invited Reviewed International journal

    Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.

    Elife   10   e66155   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.66155

  • Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis Reviewed International journal

    Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.

    Nature Commun   12   2883   2021.6

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    DOI: 10.1038/s41467-021-23050-x

  • Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord Reviewed International journal

    Yasukochi S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Pharmacol   185   114411   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bcp.2021.114411

    Other Link: https://pubmed.ncbi.nlm.nih.gov/33428896/

  • Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines Reviewed International journal

    Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A

    ACS Med Chem Lett   11   1137 - 1144   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsmedchemlett.9b00574

  • Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity in mice Reviewed International journal

    Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S

    Sci Rep   10   13484   2020.10

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    DOI: 10.1038/s41598-020-70321-6

  • Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins Reviewed International journal

    Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A

    J Am Chem Soc   142   18522 - 18531   2020.10

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    DOI: 10.1021/jacs.0c07490

  • Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches Invited Reviewed International journal

    Kusunose N, Tsuruta A, Hamamura K, Tsurudome Y, Yoshida Y, Akamine T, Matsunaga N, Koyanagi S, Ohdo S

    Genes Cells   25   2020.3

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    DOI: 10.1111/gtc.12758

  • Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs Invited Reviewed International journal

    Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S Ohdo S

    Biochem Biophys Res Commun   519   2019.10

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    DOI: 10.1016/j.bbrc.2019.09.021

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes Reviewed International journal

    Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M

    Br J Pharmacol   176   3723 - 3738   2019.5

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    DOI: 10.1111/bph.14777

  • Time-dependent changes in the anti-tumor effect of xCT inhibitor erastin in human breast cancer xenograft mice Reviewed International journal

    Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biol Pharm Bull   42   2019.5

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    DOI: 10.1248/bpb.b19-00546

  • Microcurrent stimulation activates the circadian machinery in mice Reviewed International journal

    Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   513   2019.5

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    DOI: 10.1016/j.bbrc.2019.02.022

  • Selective and Reversible Modification of Kinase Cysteines with Chlorofluoroacetamides Reviewed International journal

    Shindo N, Fuchida H Sato H, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunag K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A

    Nature Chem Biol   2019.1

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  • Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene Reviewed International journal

    Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S

    J Biol Chem   294   547 - 558   2019.1

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  • Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function Reviewed International journal

    Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S

    Sci Rep   8   2018.12

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  • Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system Reviewed International journal

    Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   2018.9

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  • Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model Reviewed International journal

    Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   503   181 - 187   2018.9

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  • Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase inhibitor Invited Reviewed International journal

    Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S

    Cancer Res   2018.8

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  • Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Reviewed International journal

    Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S

    Biochem Biophys Res Commun   2018.7

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  • Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells Reviewed International journal

    2018.7

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  • Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice Reviewed International journal

    Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

    J Pharmacol Sci   136 ( 228-233 )   2018.5

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  • 母集団薬効解析によるアロプリノールからフェブキソスタットへ切替え時の血清尿酸値に及ぼす影響因子の探索 Reviewed

    緒方貴洸, 兼重 晋, 松尾宏一, 松永直哉, 小柳 悟, 大戸茂弘, 神村英利

    医療薬学(Jpn J Pharmaceu Health Care Sci)   2018.3

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  • Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα Reviewed International journal

    292 ( 21397-21406 )   2017.12

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  • Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis Reviewed International journal

    Scientific Reports   73   2017.8

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  • Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light–dark cycle in mice Reviewed International journal

    134 ( 211-217 )   2017.8

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  • 電子カルテ記録に基づいたアロプリノール製剤の母集団薬効動態解析 Reviewed

    緒方貴洸, 兼重 晋, 松尾宏一, 松永直哉, 小柳 悟, 大戸茂弘, 神村英利

    医療薬学(Jpn J Pharmaceu Health Care Sci)   2017.5

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  • Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells Reviewed International journal

    Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Masuda S, Matsunaga N, Koyanagi S, Ohdo S.

    Eur J Pharmacol   800 ( 48-56 )   2017.4

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  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed International journal

    Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Kazutaka T, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Makoto T, Inoue K, Ojida A, Koyanagi S, Ohdo S.

    EBioMedicine   13 ( 262-273 )   2016.11

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  • Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock Reviewed International journal

    Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagi S, Ogawa H, Okumura K, Shibata S, Nakao A

    J Allergy Clin Immun   4   2016.4

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  • Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction Invited Reviewed International journal

    Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S

    J Biol Chem   10 ( 4913-4927 )   2016.3

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  • Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression Invited Reviewed International journal

    Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S

    J Biol Chem   13 ( 7017-7028 )   2016.3

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  • Circadian modulation in the intestinal absorption of p-glycoprotein substrates in monkeys Reviewed International journal

    Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S:

    Mol Pharmacol   1   2015.7

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  • Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice Reviewed International journal

    Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguichi M, Matsunaga N, Ohdo S

    J Pharmacol Exp Ther   2015.5

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  • Modulation of Peroxisome Proliferator-Activated Receptor-alpha Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice Reviewed International journal

    Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S;

    Mol Pharmacol   2 ( 314-322 )   2015.2

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  • Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1 Reviewed International journal

    36   2014.9

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  • Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice Reviewed International journal

    Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.

    Mol Pharmacol   5 ( 715-722 )   2014.5

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  • 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks. Reviewed International journal

    Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.

    J Invest Dermatol   6   2014.1

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  • Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma Reviewed International journal

    Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S

    Cancer Res   2 ( 543-551 )   2014.1

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  • The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S Reviewed International journal

    Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H

    Scientific Reports   2013.9

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  • Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes Reviewed International journal

    Karakawa S, Miyoshi Y, Konno R, Koyanagi S, Mita M, Ohdo S, Hamase K

    Anal Bioanal Chem   25   2013.9

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  • Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum Reviewed International journal

    Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.

    Mol Pharmacol   5   2013.2

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    Other Link: http://www.ncbi.nlm.nih.gov/pubmed/23429911

  • The molecular clock regulates circadian transcription of tissue factor gene Reviewed International journal

    Oishi K, Koyanagi S, Ohkura N

    Biochem Biophys Res Commun   2 ( 332-335 )   2013.2

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  • A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease Reviewed International journal

    Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.

    Neuromolecular Med   2013.1

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    Other Link: http://www.ncbi.nlm.nih.gov/pubmed/23292542

  • The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis. Reviewed International journal

    Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.

    Hum Immunol.   74   2012.11

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  • Induction of Cardiac Fibrosis by beta-Blocker in G Proteinin-dependent and G Protein-coupled Receptor Kinase 5/beta-Arrestin2-dependent Signaling Pathways Reviewed International journal

    Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.

    J Biol Chem   42 ( 35669-35677 )   2012.10

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  • Role of Activating Transcription Factor-4 in 24-Hour Rhythm of Serotonin Transporter Expression in the Mouse Midbrain Reviewed International journal

    Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.

    Mol Pharmacol   2 ( 264-270 )   2012.8

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  • Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian Expression of CYP2D6 in Serum-shocked HepG2 Cells. Reviewed International journal

    5 ( 739-747 )   2012.2

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  • Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner. Reviewed International journal

    Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

    Toxicology   290 ( 204-208 )   2011.12

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  • Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice Reviewed International journal

    Oishi K, Koyanagi S, Ohkura N.

    Exp Gerontol   12 ( 994-999 )   2011.11

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  • Methotrexate chronotherapy is effective against rheumatoid arthritis. Reviewed International journal

    To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K.

    Chronobiol Int.   3 ( 267-274 )   2011.4

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  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats Reviewed International journal

    Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K

    Brain   4 ( 1127-1139 )   2011.3

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  • Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes Reviewed International journal

    Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.

    Toxicology   3 ( 144-151 )   2010.12

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  • Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain Reviewed International journal

    Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.

    Mol. Pain   6 ( 83 )   2010.11

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  • Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice Reviewed International journal

    Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.

    Cancer Res.   15 ( 6238-6246 )   2010.11

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  • Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice Reviewed International journal

    27 ( 1735-1753 )   2010.11

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  • Hypoxia-Response Plasmid Vector Producing bcl-2 shRNA Enhances the Apoptotic Cell Death of Mouse Rectum Carcinoma Reviewed International journal

    Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S

    J Pharmacol Sci   113 ( 4 )   2010.8

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  • Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner Reviewed International journal

    Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S.

    Mol Pharmacol   2010.4

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  • Glucocorticoid-dependent expression of O6-methylguanine-DNA methyltransferase gene modulates the dacarbazine-induced hepatotoxicity in mice Reviewed International journal

    Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.

    J Pharmacol Exp Ther   3 ( 782-787 )   2010.3

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  • Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene. Reviewed International journal

    Kim J, Matsunaga N, Koyanagi S, Ohdo S.

    Biochem Pharmacol.   8 ( 1075-1082 )   2009.11

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  • Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation Reviewed International journal

    Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E.

    Life Sci.   9 ( 372-378 )   2009.8

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  • Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride. Reviewed International journal

    Akagi T, Fukagawa T, Kage Y, To H, Matsunaga N, Koyanagi S, Uchida A, Fujii A, Iba H, Ikemura T, Aramaki H, Higuchi S, Ohdo S.

    J Pharmacol Sci   2 ( 265-274 )   2009.3

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  • Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis. Reviewed International journal

    Tojo Y, Hamase K, Konno R, Koyanagi S, Ohdo S, Zaitsu K.

    J Sep Sci.   3 ( 430-436 )   2009.2

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  • Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system Reviewed International journal

    Soeda S., Koyanagi S., Kuramoto Y., Kimura M., Oda M., Kozako T., Hayashida S., Shimeno H.

    Thromb. Haemost.   100 ( 1014-1020 )   2008.12

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  • Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts. Reviewed International journal

    Morikawa A., Hamase K., Miyoshi Y., Koyanagi S., Ohdo S., and Zaitsu K.

    J Chromatogr B Analyt Technol Biomed Life Sci.   875 ( 168-173 )   2008.11

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  • Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function Reviewed International journal

    Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S.

    Life Sci.   83 ( 574-580 )   2008.8

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  • Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling Reviewed International journal

    Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S.

    J. Pharmacol. Sci.   107 ( 401-407 )   2008.8

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  • The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver. Reviewed International journal

    Matsunaga N., Ikeda M., Takiguchi T., Koyanagi S., and Ohdo S.

    Hepatology   48 ( 240-251 )   2008.7

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  • Clock gene dysfunction in patients with obstructive sleep apnoea syndrome Reviewed International journal

    Burioka N., Koyanagi S., Endo M., Takata M., Fukuoka Y., Miyata M., Takeda K., Chikumi H., Ohdo S., and Shimizu E.

    Eur. Respir. J.   32 ( 105-112 )   2008.7

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  • Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances Reviewed International journal

    Terazono H., Hamdan A., Matsunaga N., Hayasaka N., Kaji H., Egawa T., Makino K., Shigeyoshi Y., Koyanagi S., and Ohdo S.

    Biochem. Pharmacol.   75 ( 1616-1622 )   2008.4

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  • Basic-helix-loop-helix (bHLH) transcription factor DEC2 binds to HIF-1α and negatively regulates the expression of vascular endothelial growth factor. Reviewed International journal

    13 ( 131-144 )   2008.2

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  • Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice Reviewed International journal

    Nakagawa H., Takiguchi T., Nakamura M., Furuyama A., Koyanagi S., Aramaki H., Higuchi S., Ohdo S.

    Biochem. Pharmacol.   72   2006.11

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  • Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways Reviewed International journal

    Soeda S, Shinomiya K, Ochiai T, Koyanagi S, Toda A, Eyanagi R, Shimeno H

    Neuroscience   141 ( 101-108 )   2006.8

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  • Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver Reviewed International journal

    Koyanagi S., Suyama H., Kuramoto Y., Matsunaga N., Takane H., Soeda S., Shimeno H., Higuchi S., Ohdo S.

    Endocrinology   147 ( 5037-5040 )   2006.8

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  • Cell cycle dependent pharmacology of methotrexate in HL-60 Reviewed International journal

    Yamauchi A., Ichimiya T., Inoue K., Taguchi Y., Matsunaga N., Koyanagi S., Fukagawa T., Aramaki H., Higuchi S., Ohdo S.

    J Pharmacol Sci   99 ( 335-341 )   2006.6

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  • Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine Reviewed International journal

    Yoshida M, Kiyofuji H, Koyanagi S, Matsuo A, Fujioka T, To H, Higuchi S, Ohdo S.

    J Pharmacol Sci.   101 ( 77-84 )   2006.5

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  • Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors Reviewed International journal

    Hikishima S., Isobe M., Koyanagi S., Soeda S., Shimeno H., Shibuya S., Yokomatsu T.

    Bioorg. Med. Chem.   14 ( 1660-1670 )   2006.5

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  • Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues Reviewed International journal

    Koyanagi S., Okazawa S., Kuramoto Y., Ushijima K., Shimeno H., Soeda S., Okamura H., Ohdo S.

    Mol. Endocrinol.   20 ( 573-583 )   2006.4

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  • Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones Reviewed International journal

    Kuramoto Y., Hata K., Koyanagi S., Ohdo S., Shimeno H., Soeda S.

    Biochem. Pharmacol   71 ( 1155-1161 )   2006.4

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  • Glucocorticoid hormone regulates the circadian coordination of ?-opioid receptor expression in mouse brainstem. Reviewed International journal

    Yoshida M., Koyanagi S., Matsuo A., Fujioka T., To H., Higuchi S., Ohdo S.

    J. Pharmacol. Exp. Ther.   3 ( 1119-1124 )   2005.12

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  • Chronopharmacological study of antidepressants in forced swimming test in mice Reviewed International journal

    Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., Higuchi S., Ohdo S.

    J. Pharmacol. Exp. Ther.   2 ( 764-770 )   2005.11

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  • Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder Reviewed International journal

    Takimoto M., Hamada A., Tomoda A., Ohdo S., Ohmura T., Sakato H., Kawatani J., Jodoi T., Nakagawa H., Terazono H., Koyanagi S., Higuchi S., Kimura M., Tukikawa H., Irie S., Saito H., Miike T.

    Am. J. Physiol. Regul. Integr. Comp. Physiol.   5 ( 1273-1279 )   2005.11

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  • Plasminogen activator inhibitor-1 aids survival of neuritis on neurons derived from pheochromyctoma (PC-12) cells Reviewed International journal

    Soeda S., Imatoh T., Ochiai T., Koyanagi S., Shimeno H.

    Neuroreport   ( 855-858 )   2004.4

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  • 24-hr oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression is regulated by clock gene proteins Reviewed International journal

    Nakagawa H., Koyanagi S., Takiguchi T., Soeda S., Shimeno H., Higuchi S., Ohdo S.

    Cancer Res.   64 ( 22 )   2004.1

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  • Elevation of de novo ceramide synthesis in tumor masses and a role of the microsomal dihydroceramide synthase Reviewed International journal

    Koyanagi S., Kuga M., Soeda S., Hosoda Y., Yokomatsu T., Takeuchi H., Akiyama T., Shibuya S., Shimeno H.

    Int. J. Cancer   ( 1-6 )   2003.5

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  • Optimizing the dosing schedule of TNP-470 enhances its antitumor and anti-angiogenic efficacies Reviewed International journal

    Koyanagi S., Nakagawa H., Kuramoto Y., Ohdo S., Soeda S., Shimeno H.

    J. Pharmacol. Exp. Ther.   2 ( 669-674 )   2003.2

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  • Oversulfation of fucoidan enhances its anti-angiogenic and anti-tumor activities Reviewed International journal

    Koyanagi S., Tanigawa N., Nakagawa H., Soeda S., Shimeno H.

    Biochem. Pharmacol.   ( 173-179 )   2003.1

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  • Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism Reviewed International journal

    Koyanagi S., Ohdo S.

    Mol. Pharmacol.   6 ( 1393-1399 )   2002.11

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  • An attempt to promote neovascularization by employing a newly synthesized inhibitor of protein tyrosine phosphatase Reviewed International journal

    Soeda S., Shimada T., Koyanagi S., Yokomatsu T., Murano T., Shibuya S., Shimeno H.

    FEBS Lett.   ( 54-58 )   2002.7

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  • Relationship between diurnal rhythm of cell cycle and interferon receptor in implanted-tumor cell Reviewed International journal

    Takane H., Ohdo S., Yamada T., Koyanagi S., Yukawa E., Higuchi S.

    Life Sci.   12 ( 1449-1455 )   2001.2

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  • Effects of dosing schedule on pharmacokinetics of alpha-interferon and anti-alpha interferon neutralizing antibody in mice Reviewed International journal

    Wang D.S., Ohdo S., Koyanagi S., Takane H., Aramaki H., Yukawa E., Higuchi S.

    Antimicrob. Agents. Chemother.   ( 176-180 )   2001.1

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  • Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases Reviewed International journal

    Yokomatsu T., Hayakawa Y., Kihara T., Koyanagi S., Soeda S., Shimeno H., Shibuya S.

    Bioorg Med Chem   11 ( 2571-2579 )   2000.11

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  • Basis for dosing time-dependent changes in the antiviral activity of interferon-α in mice Reviewed International journal

    2 ( 488-493 )   2000.8

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  • Relationship between 24-hr rhythm in antiviral effect of interferon-β and interferon-α/β receptor expression in mice Reviewed International journal

    ( 304-312 )   2000.2

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  • Chronopharmacological study of interferon-α in mice Reviewed International journal

    1 ( 259-264 )   1997.6

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  • Circadian rhythm of fever induced by interferon-alpha in mice Reviewed International journal

    Ohdo S., Koyanagi S., Yukawa E., Higuchi S.

    Life Sci.   8 ( PL95-100 )   1997.1

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Books

  • Perspective 薬剤学 第3版

    大戸茂弘 編著( Role: Joint author)

    京都廣川書店  2019.3 

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    Language:Japanese   Book type:Scholarly book

  • Biological Clock with reference to suprachiasmatic nucleus

    Koyanagi S, Kusunose N, Matsunaga N, Ohdo S.( Role: Joint author)

    2017.11 

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    Language:English   Book type:Scholarly book

  • 時間薬理学による最新の治療戦略

    大戸茂弘 他( Role: Joint author)

    医薬ジャーナル社  2013.4 

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    Language:Japanese   Book type:Scholarly book

  • Perspective 薬剤学

    大戸茂弘 編著( Role: Joint author)

    京都廣川書店  2011.3 

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    Language:Japanese   Book type:Scholarly book

  • Angiogenesis; Functional and Medicinal Foods

    Soeda S., Koyanagi S., Shimeno H.( Role: Joint author)

    Marcel Decker N.Y.  2007.4 

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    Language:English   Book type:Scholarly book

  • 時間学の構築III

    小柳 悟, 大戸 茂弘( Role: Joint author)

    山口大学時間学研究所  2019.3 

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    Responsible for pages:171-192   Language:Japanese   Book type:General book, introductory book for general audience

  • 臨床現場で実践する薬学研究のススメ

    小柳悟、大戸茂弘( Role: Joint author)

    南山堂  2014.10 

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    Responsible for pages:108-113   Language:Japanese   Book type:Scholarly book

    「ウェット」研究でよくあるトラブルへの対処法

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Presentations

  • 神経障害性疼痛の概日変動メカニズム Invited

    小柳 悟

    第45回日本疼痛学会  2023.12 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福島市   Country:Japan  

  • Circadian clock and Chronopharmacology Invited International conference

    Koyanagi S.

    Annual Meeting Taiwan Pharmaceutical Society  2020.11 

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    Event date: 2021.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Taiwan, Province of China  

  • 概日リズム研究の創薬・医療への応用 Invited

    小柳 悟

    第11回次世代を担う若手医療薬科学シンポジウム  2017.10 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都薬科大学   Country:Japan  

  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of pain hypersensitivity after peripheral nerve injury Invited International conference

    Satoru Koyanagi

    Sapporo Symposium on Biological Rhythm in 2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Molecular basis for circadian sensitivity of tumor cells to chemotherapeutic agents Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    Spring Annual Convention of Pharmaceutical Society of Korea  2014.4 

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    Event date: 2014.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 神経障害性疼痛の概日リズム形成メカニズムと鎮痛標的分子の探索

    小柳 悟, 楠瀬直喜, 大戸 茂弘

    日本薬学会第134年会  2014.3 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 体内時計による薬物動態の制御と副作用の低減 Invited

    小柳悟、松永直哉、大戸茂弘

    第85回日本薬理学会  2012.3 

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    Event date: 2012.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都国際会議場   Country:Japan  

  • 概日時計の分子機構を基盤にした薬物投与設計と多剤併用療法への応用 Invited

    小柳 悟、松永直哉、大戸茂弘

    日本薬剤学会第26回年会  2011.5 

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    Event date: 2011.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 消化管におけるトランスポーター発現の日内変動を制御する分子メカニズム Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会131回年会  2011.3 

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    Event date: 2011.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:静岡   Country:Japan  

  • 時間薬物療法:体内時計に基づいた創薬・育薬研究 Invited

    小柳悟、松永直哉、大戸茂弘

    第17回日本時間生物学会学術大会  2010.11 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:早稲田大学井深ホール   Country:Japan  

  • 分子時計による薬物代謝・排泄の日周リズム制御機構 Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会第129年会  2009.3 

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    Event date: 2009.3

    Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  • Molecular mechanism underlying circadian rhythms of xenobiotic transporters and CYPs Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    19th North American ISSX / 29th JSSX Meeting  2014.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 〜時間薬理学における基礎と臨床の融合研究〜ヒト近位尿細管細胞におけるRNA編集酵素の概日リズムと薬物排泄トランスポーター発現の制御 Invited

    小柳 悟

    第32回日本医療薬学会年会  2022.9 

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    Event date: 2022.9 - 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 時間栄養学と時間薬理学の接点 〜 生体膜輸送トランスポーターの発現リズム制御〜 Invited

    小柳 悟

    第9回日本時間栄養学会 教育講演  2022.8 

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    Event date: 2022.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:GLOCAL HOTEL ITOSHIMA    Country:Japan  

  • RNA編集酵素によるヒト近位尿細管細胞における薬物排泄トランスポーター発現の概日リズム制御 Invited

    小柳 悟、小俣 裕司、大戸 茂弘

    第49回日本毒性学会学術年会  2022.6 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • RNA splicingの時刻変動によるP糖タンパク質の発現リズム制御 Invited

    小俣 裕司、山内 智暁、鶴田 朗人、松永 直哉、小柳 悟、大戸 茂弘

    日本薬剤学会第36年会  2021.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • オキサリプラチン誘発性の骨髄抑制に及ぼすMRP4発現の概日リズムの影響

    小柳 悟、加藤泉希、鶴留優也、金光拓海、安河内冴、金堂有起、荻野敬史、松永直哉、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • フェブキソスタットのBCRP機能阻害によるスルファサラジンの消化管吸収改善と末梢神経障害性疼痛緩和作用に及ぼす効果

    安河内冴、山川稚葉、山内智暁、小俣裕司、鶴田朗人、松永直哉、小柳悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • RNA編集酵素ADAR1によるヒト腎近位尿細管上皮細胞でのP糖タンパク質発現の概日リズム制御

    小俣裕司、大川ませ梨、鶴田朗人、松永直哉、小柳悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • RNA編集酵素ADAR1による「環状RNA」発現制御を介したヒト腎細胞におけるMRP4発現制御機構の解析

    小俣裕司、小柳 悟、大戸茂弘

    日本薬物動態学会 第36回年会  2021.11 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 白金製剤オキサリプラチン誘発の骨髄抑制に及ぼす薬物排泄トランスポーター MRP4の概日リズムの影響

    小柳 悟、加藤泉希、鶴留優也、安河内 冴、松永直哉、大戸茂弘

    メタルバイオサイエンス研究会2021  2021.10 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • Basis for generation of pathological circadian rhythms and its application for drug development Invited International conference

    Satoru Koyanagi

    The 94th Annual Meeting of the Japanese Biochemical Society  2021.11 

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    Event date: 2022.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • がん化した時計遺伝子の機能不全細胞における薬剤耐性能獲得機構 Invited

    小柳悟、松永直哉、大戸茂弘

    第27回日本時間生物学会学術大会  2020.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web開催   Country:Japan  

  • Chronopharmacology based on circadian clock-regulated xenobiotic transporters Invited International conference

    Koyanagi Satoru

    2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX  2018.10 

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    Event date: 2018.10 - 2020.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Circadian clock regulation of intra-individual variations in drug disposition; Translational research of chrono-pharmacokinetics Invited International conference

    Satoru Koyanagi

    International Conference of Precision Medicine  2017.11 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Translational research of chrono-pharmacokinetics Invited International conference

    Satoru Koyanagi

    Joint Symposium Hokkaido Univ. Taipei Medical Univ. Kyushu Univ.  2017.9 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 時間薬理学的アプローチによる難治性がんの治療戦

    小柳 悟, 片宗 千春, 松永 直哉, 大戸 茂弘

    第92回日本薬理学会年会  2018.3 

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    Event date: 2018.3 - 2020.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Molecular basis for chronopharmacokinetics and chronopharmacology of chemotherapeutic agents Invited International conference

    2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 薬物動態の概日リズム研究におけるトランスレーショナルリサーチ Invited

    小柳悟、松永直哉、大戸茂弘

    日本薬学会第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜市   Country:Japan  

  • 培養細胞での概日時計メカニズムを応用した細胞がん化抑制機構の解明 Invited

    小柳 悟

    日本動物実験代替法学会第26回大会  2013.12 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 概日時計因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御 Invited

    小柳 悟, 松永 直哉, 大戸 茂弘

    第35回生体膜と薬物の相互作用シンポジウム  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 時間薬物動態におけるトランスレーショナルリサーチ

    小柳 悟, 松永 直哉, 大戸 茂弘

    第20回日本時間生物学会学術大会  2013.11 

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    Event date: 2013.11 - 2013.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Molecular mechanism regulating circadian expression of drug metabolism enzymes in human Invited

    Koyanagi Satoru, matsunaga naoya, shigehiro ohdo

    2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 転写因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御 Invited

    小柳 悟

    第8回トランスポーター研究会  2013.6 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 6年制の薬学部学生に対する研究指導 〜医療薬学系教官の立場から〜

    小柳 悟

    第27回日本薬学会九州支部大会  2010.12 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎大学薬学部   Country:Japan  

  • Manipulation of feeding schedule can modulate the antiviral effect of Interferon-α

    2008.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 抗がん剤の効果・毒性の日内変動を制御する分子メカニズム Invited

    小柳悟、松永直哉、大戸茂弘

    第4回日本緩和医療薬学会年会  2010.9 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島市民会館   Country:Japan  

  • 体内時計の分子機構を基盤にした薬物投与設計 Invited

    小柳悟、松永直哉、大戸茂弘

    医療薬学フォーラム2010/第18回クリニカルファーマシーシンポジウム  2010.7 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島国際会議場   Country:Japan  

  • 抗がん剤の時間薬理 Invited

    大戸茂弘、松永直哉、小柳悟

    医療薬学フォーラム2009 第17回クリニカルファーマシーシンポジウム  2009.7 

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    Event date: 2009.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Chrono-drug delivery of antitumor drugs: molecular clock mechanisms Invited International conference

    Ohdo S, Matsunaga N, Koyanagi S

    International Joint Seminar  2008.11 

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    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 薬物活性リズムの体内時計の分子機構 Invited

    大戸茂弘、松永直哉、小柳悟

    第15回日本時間生物学会学術大会  2008.11 

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    Event date: 2008.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山大学   Country:Japan  

  • Dosing-time dependent antitumor effects of Transferrin-Liposome Oxaliplatin (Tf-Lip-L-OHP) in tumor bearing mice International conference

    Ohdo S, Okazaki F, Maruyama K, Matsunaga N, Koyanagi S.

    11th Liposome Research Days Conference  2008.7 

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    Event date: 2008.7

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Chronopharmacology of interferon-α in mice International conference

    1999.8 

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    Venue:Williamsburg   Country:United States  

  • 時計遺伝子に着目した時間治療の可能性 Invited

    小柳 悟

    日本薬学会第122回年会  2002.3 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:千葉   Country:Japan  

  • Molecular basis for circadian expression of cascular endothelial growth factor in tumor cells International conference

    The 1st World Congress of Chronobiology  2003.6 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Studies on optimizing dosing schedule of angiogenesis inhibitor International conference

    Nakagawa H., Koyanagi S., Takiguchi T., Kuramoto Y., Ohdo S., Higuchi S.

    2nd Pharmaceutical Sciences World Congress  2004.6 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 体内時計とがんの時間治療 Invited

    小柳 悟

    日本薬学会第125回年会  2005.3 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Circadian clock and chronopharmacology of anti-tumor drug Invited

    Koyanagi S.

    8th International symposium on recent advances in drug discovery and development  2007.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 時計遺伝子とがんの時間薬物療法 Invited

    小柳 悟

    時間循環血圧研究会  2007.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine International conference

    Ohdo S., Murakami Y., Higashi Y., Matsunaga N., Koyanagi S.

    2007.6 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 生体リズムを駆使した抗がん剤の時間治療 Invited

    小柳 悟

    第80回日本薬理学会  2007.3 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • Chronopharmacology of angiogenesis inhibitors Invited International conference

    Koyanagi S.

    2nd World Congress of Chronobiology  2007.11 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Circadian clock-controlled expression of the multidrug resistance gene mdr1a in mouse small intestine International conference

    Ohdo S., Murakami Y., Higashi Y., Matsunaga N., Koyanagi S.

    2nd World Congress of Chronobiology  2007.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells. International conference

    Koyanagi S., Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Ohdo S.

    2nd World Congress of Chronobiology  2007.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Chronopharmacological study of hepatotoxicity induced by acetaminopehn in mice International conference

    Matsunaga N., Ikeda M., Takiguchi T., Koyanagi S., Ohdo S.

    2nd World Congress of Chronobiology  2007.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 体内時計の分子機構を駆使したがん時間化学療法の可能性 Invited

    小柳 悟

    第1回次世代を担う若手医療薬科学シンポジウム  2007.12 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 食品の機能性を時間生物学的視点から考える Invited

    大戸茂弘、小柳悟、松永直哉

    日本農芸化学会2012年度大会  2012.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 生体リズム研究と時間治療の動向と展望

    小柳 悟

    医療薬学フォーラム2012 第20回クリニカルファーマシーシンポジウム  2012.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Chronopharmacology based on molecular clock Invited

    2013.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • がん細胞の抗がん剤感受性の日周リズム制御機構

    小柳 悟, 松永 直哉, 大戸 茂弘

    第86回日本薬理学会学術大会  2013.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 生体リズムにマッチしたクロノセラピィー Invited

    大戸茂弘、小柳悟、松永直哉

    日本薬剤学会 第28年会  2013.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 時間薬理学の現状と将来 Invited

    大戸茂弘、小柳悟、松永直哉

    第128回 日本薬理学会関東部会  2013.7 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング Invited

    大戸茂弘、小柳悟、松永直哉

    第86回 日本生化学会  2013.9 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Chronopharmacological aspects of transporters Invited

    2013.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Exploration of analgesic target for neurophatic pain based on the molecular mechanism of circadian rhythm in allodynia Invited

    Koyanagi Satoru, Naoki Kusunose, Shigehiro Ohdo

    2014.10 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 概日時計を活用した疾患の予防・診断・治療

    小柳 悟、藤 秀人

    第21回日本時間生物学会学術大会  2014.11 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Molecular basis of chrono-pharmacokinetics and chrono-pharmacology Invited International conference

    Koyanagi Satoru, Shigehiro Ohdo

    2015.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Molecular mechanism underlying circadian rhythms in drug metabolism and excretion Invited

    2015.6 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 場タンパク質(NHERF1)の発現リズムに基づいた肝細胞膜トランスポーターの機能制御

    鶴留優也,小柳 悟,松永直哉,大戸茂弘

    日本薬剤学会第31年会  2016.5 

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    Presentation type:Oral presentation (general)  

    Venue:岐阜市   Country:Japan  

  • 眼内VEGFの時計遺伝子DEC2依存的発現制御

    楠瀬直喜,小林義行,吉田茂生,木許賢一,小柳悟,大戸茂弘,久保田敏昭

    第20回 眼創傷治癒研究会  2016.8 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 細胞がん化に及ぼす時計遺伝子の機能的差異の影響:培養細胞を用いた検討

    片宗千春,白水翔也,橋川健一,松永直哉,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 肝細胞癌の発症を抑制する新規低分子化合物の探索

    東和博,鶴田朗人,渡遣美弥子,松永直哉,柿本啓輔,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 転写因子に着目した難治性乳がんの新規治療法の検討

    荻野敬史,松永直哉,原幸稔,田仲孝広,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 細胞がん化時における異常増殖能の獲得に必要なアミノ酸の同定

    白水翔也,山口悠太,片宗千春,橋川健一,村上千帆,松永直哉,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 培養尿細管上皮細胞を用いた薬剤性腎障害の評価系構築

    坂本裕哉,矢野貴久,竹下亜希,稲垣芙美佳,松永直哉, 小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 培養細胞を用いた皮膚の分子時計解析アクアポリン3発現の概日リズム制御機構

    松永直哉,一町和史,小柳 悟,大戸茂弘

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 体内時計の分子機構を基盤とした、虚血網膜におけるVEGF発現上昇メカニズムの解明

    楠瀬直喜,小林義行,吉田茂生,木許賢一,小柳悟,大戸茂弘,久保田敏昭

    第29回日本動物実験代替法学会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • バンコマイシン誘発尿細管上皮細胞アポトーシスにおけるROSおよびMAPKの役割

    坂本裕哉, 矢野貴久, 稲垣芙美佳, 松永直哉, 小柳 悟, 大戸茂弘

    第69回 日本薬理学会西南部会  2016.11 

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    Presentation type:Oral presentation (general)  

    Venue:松山市   Country:Japan  

  • がん細胞の異常増殖能獲得に寄与するアミノ酸の同定およびアミノ酸取込み阻害剤による細胞増殖抑制効果の検討

    白水翔也,山口悠太,松永直哉,小柳悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

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    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • バンコマイシンによる尿細管上皮細胞障害におけるミトコンドリアの役割と抗酸化薬の効果

    稲垣芙美佳,矢野貴久,坂本裕哉,松永直哉,小柳悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

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    Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • オキサリプラチンの骨髄抑制作用に及ぼすMRP4発現の概日リズムの影響

    加藤泉希,鶴留優也,金堂有起,森田朱莉,松永直哉,小柳 悟大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

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    Venue:鹿児島市   Country:Japan  

  • Aldehyde dehydrogenase活性を指標としたトリプルネガティブ乳がんの時間薬理学的研究

    原 幸稔,松永直哉,荻野敬史,田仲孝広,岩本真由香,楠瀬直喜,小柳 悟,大戸茂弘

    第33回日本薬学会九州支部大会  2016.12 

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    Venue:鹿児島市   Country:Japan  

  • 電子カルテ記録に基づいた母集団薬効動態解析によるアロプリノールの先発品と後発品の治療効果の比較

    緒方貴洸, 兼重 晋, 松尾宏一, 楠瀬直喜, 松永直哉, 神村英利, 小柳 悟, 大戸茂弘

    第2回臨床薬理学会九州・沖縄地方会  2017.6 

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    Venue:那覇市   Country:Japan  

  • 慢性腎臓病時の炎症概日リズムに基づく新規治療薬の開発

    松永直哉、鶴田朗人、吉田優哉、中尾崇治、高露 恵理子、濱村賢吾、渡邊美弥子、近藤英明、小柳 悟、大戸茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.9 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 慢性腎臓病モデルマウスにおける分子時計を介した腎‐肝‐腎連関機構の解明

    中尾崇治、松永直哉、吉田優哉、鶴田朗人、濵村賢吾、近藤英明、小柳 悟、大戸茂弘

    第11回日本腎臓病薬物療法学会学術集会  2017.9 

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    Venue:福岡市   Country:Japan  

  • 足場タンパク質の発現リズムに基づいた脂肪酸取り込みトランスポーターの機能シミュレーションモデルの構築

    森田朱莉、鶴留優也、赤嶺孝祐、金堂有起、嶋岡雄大、楠瀬直喜、松永直哉、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

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    Venue:熊本市   Country:Japan  

  • 概日リズムの制御機構におけるドパミン D3 受容体の機能解析

    羽山千尋、松田将希、吉田優哉、松永直哉、楠瀬直喜、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

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    Venue:熊本市   Country:Japan  

  • 慢性腎臓病モデルマウスにおける分子時計を介した 腎・心病態悪化機構の解明

    吉田優哉、松永直哉、鶴田朗人、中尾崇治、羽山千尋、黒木雅礼、楠瀬直喜、小柳 悟、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

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    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • 足場タンパク質 NHERF1 の発現リズムに基づいた 肝細胞膜トランスポーターの機能制御

    鶴留優也、小柳 悟、片宗千春、森田朱莉、金光拓海、金堂有起、加藤泉希、楠瀬直喜、松永直哉、大戸茂弘

    第34回日本薬学会九州支部大会  2017.11 

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    Venue:熊本市   Country:Japan  

  • The role of molecular clock in the alterations of hepatic metabolism in chronic kidney disease. International conference

    Ohdo S, Matsunaga N, Koyanagi S

    2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX  2018.10 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Circadian scaffolding function of NHERF1 for plasmalemmal expression of xenobiotic transporter in mouse liver,

    2018.10 

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    Country:Japan  

  • 体内時計の分子機構を基盤とした、虚血網膜におけるVEGF 発現上昇メカニズムの解明

    楠瀬直喜、赤嶺孝祐、松永直哉、小柳 悟、 久保田敏昭、大戸茂弘

    第25 回 日本時間生物学会学術大会  2018.10 

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    Venue:長崎市   Country:Japan  

  • 概日時計機構を基盤とした腎障害誘発心線維化の新規メカニズム解明

    吉田優哉、 松永直哉、 鶴田朗人、 楠瀬直喜、 小柳 悟、大戸茂弘

    第25 回 日本時間生物学会学術大会  2018.10 

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    Venue:長崎市   Country:Japan  

  • 既存薬ライブラリーを用いた新規神経障害性疼痛治療薬の探索

    安河内冴、楠瀬直喜、山口悠太、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

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    Venue:福岡市   Country:Japan  

  • 炎症関連受容体Xを標的とした慢性腎不全時の心炎症抑制化合物の探索

    山口悠太、楠瀬直喜、安河内冴、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

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    Venue:福岡市   Country:Japan  

  • 薬剤経眼投与による生体リズム調整法の構築

    嶋岡雄大、楠瀬直喜、鶴留優也、松永直哉、小柳 悟、大戸茂

    第35回日本薬学会九州支部大会  2018.11 

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    Venue:福岡市   Country:Japan  

  • Ccrfを標的とした新規慢性肝炎治療薬の開発

    柴田愛実、鶴田朗人、松永直哉、楠瀬直喜、小柳 悟、大戸茂弘

    第35回日本薬学会九州支部大会  2018.11 

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    Venue:福岡市   Country:Japan  

  • 難治性ヒト乳がん細胞の薬剤抵抗性を改善する化合物の探索

    荻野敬史、松永直哉、岩本真由香、楠瀬直喜、小柳 悟、大戸茂弘

    日本動物実験代替法学会第31回大会  2018.11 

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    Venue:熊本市   Country:Japan  

  • Circadian clock-based strategy for exploration of approved drug to alleviate neuropathic pain hypersensitivity International conference

    Sai Yasukochi, Noaki Kusunose, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    The 48th NAITO CONFERENC  2019.10 

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    Country:Japan  

  • 神経障害性疼痛の概日リズム制御因子を標的とした既存薬ライブラリーからの鎮痛候補薬の探索

    安河内冴、楠瀬直喜、糸山さやか、松永直哉、小柳 悟、大戸茂弘

    第13回 次世代を担う若手医療薬科学シンポジウム  2019.10 

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    Venue:岐阜市   Country:Japan  

  • 単球に着目した慢性腎臓病時における心臓病態悪化の新規メカニズム解明

    吉田優哉、松永直哉、濵村賢吾、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • がん幹様細胞における転写因子の発現に着目した難治性乳がんの新規治療法に関する検討

    荻野歴史、松永直哉、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • がん細胞におけるシスチン取込みトランスポーター活性の概日リズム制御機構の解析

    山内智暁、楠瀬直喜、白水朔也、松永直哉、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • 脊髄内の脂質メデイエーターに着目したがん性癖痛の概日リズム制御機構の解析

    糸山さやか、安河内冴、楠瀬直喜、松永直哉、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • 体内時計の分子機構に及ぼすマイクロ電流刺激の影響

    北城直樹、松永直哉、吉田優哉、鶴田朗人、小柳 悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • 転写後過程おける薬物代謝酵素CYP3A4活性の概日リズム制御の解析

    田尻楓、小俣裕司、松永直哉、小柳悟、大戸茂弘

    第36回日本薬学会九州支部大会  2019.11 

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    Venue:長崎市   Country:Japan  

  • 鎮痛増悪分子SGK-1を標的としたスルファサラジンによる神経障害性疼痛に対する新規治療戦略の構築

    安河内冴,楠瀬直喜,山内智暁,山川稚葉,小俣裕司,鶴田朗人,松永直哉, 小柳悟

    第14回 次世代を担う若手医療薬科学シンポジウム  2020.11 

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    Venue:オンライン   Country:Japan  

  • 腎障害誘発性の心炎症、線維化抑制化合物の探索

    北川陽也,松永直哉,吉田優哉, 黒木雅礼, 鶴田朗人,小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • 時間薬剤学的アプローチによる神経障害性疼痛に対する鎮痛化合物の探索と新規治療戦略の構築

    安河内冴,楠瀬直喜, 山内智暁, 小俣裕司, 鶴田朗人, 松永直哉, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • がん幹様細胞における転写因子の発現に着目した難治性乳がんの新規治療法に関する検討

    荻野敬史,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • 肝臓がんの発症を抑制する新規抗炎症化合物の探索

    椎葉友輝, 松永直哉,鶴田朗人,柿本啓輔, 渡邊美弥子,小柳 悟, 大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • アクアポリン3に着目した皮膚の分子時計機構

    正門佳法,一町和史,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • パーキンソン病モデルマウスにおける生体リズム障害誘発機構

    西川直希,林亜錦,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • マウス腎がんを対象としたエベ口リムスの時間薬物治療に関する検討

    谷原智仁, 岡崎裕之,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Transferrin修飾liposome製剤を用いた癌の時間治療に関する検討

    金谷大騎, 岡崎史泰,松永直哉, 鶴田朗人, 小柳 悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • がん細胞におけるシスチン取込み卜ランスポーターを標的とした杭がん剤の時間薬理学的検討

    山内皆暁,楠瀬直喜, 白水翔也,松永直哉, 小柳悟,大戸茂弘

    第41回日本臨床薬理学会学術総会  2020.12 

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    Venue:福岡市   Country:Japan  

  • RNA編集酵素ADAR1によるヒト腎細胞でのP糖タンパク質発現の概日リズム制御機構

    小俣裕司, 山内智暁, 鶴田朗人, 松永直哉, 小柳悟, 大戸茂弘

    日本薬学会第141年会  2021.3 

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    Venue:オンライン   Country:Japan  

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MISC

  • Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development Reviewed

    Koyanagi S, Kusunose N, Yasukochi S, Ohdo S.

    J Biochem   2021.11

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    DOI: 10.1093/jb/mvab143

  • Chronopharmacological strategies focused on chrono-drug discovery Reviewed

    Ohdo S, Koyanagi S, Matsunaga N

    2021.5

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    DOI: 10.1016/j.pharmthera.2019.05.018

  • 体内時計による薬物輸送トランスポーターの概日リズム制御

    小柳 悟, 大戸茂弘

    週刊 医学のあゆみ   2013.4

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  • Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock

    Ohdo S, Koyanagi S, Matsunaga N.

    Adv Drug Deliv Rev   2010.6

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  • 血管新生のサーカディアンリズムと時間治療学

    小柳 悟

    2007.11

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  • 概日リズムとがんの時間薬物治療

    小柳 悟

    2007.10

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  • Chronopharmacology of immune-related diseases Reviewed

    1. Ohdo S, Koyanagi S, Matsunaga N

    Allergol Int   2022.10

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    DOI: 10.1016/j.alit.2022.06.006

  • 足場タンパク質によるトランスポーター細胞膜局在の概日リズム制御

    鶴留優也, 小柳 悟

    ファルマシア   2019.4

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  • 時間医薬研究の現状と展望 Reviewed

    小柳  悟

    医薬ジャーナル   2018.6

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  • 慢性疼痛の概日変動メカニズムと新しい治療標的 Reviewed

    楠瀬直樹, 小柳 悟, 松永直哉, 大戸茂弘

    医薬ジャーナル   2018.6

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  • 薬物動態の概日リズムと種差

    小柳 悟, 大戸茂弘

    2017.10

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    DOI: doi.org/10.2745/dds.32.418

  • 時間薬理学における分子基盤

    小柳悟

    生化学   2014.12

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  • 薬物動態の概日リズムとDDS開発

    小柳悟、大戸茂弘

    2014.10

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  • 体内時計による医薬品体内動態の概日リズム制御

    小柳 悟、松永 直哉、大戸 茂弘

    2013.10

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  • 生体リズムと治療

    大戸茂弘、小柳悟、松永直哉

    2013.10

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  • トランスフェリン受容体と時間薬物送達システム

    松永直哉、岡崎史泰、小柳悟、大戸茂弘

    日本臨床   2013.4

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  • 体内時計を基盤とした時間治療

    大戸茂弘、小柳悟、松永直哉

    2012.12

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  • 分子時計を基盤にした薬物動態の日内変動

    大戸茂弘、小柳悟、松永直哉

    臨床薬理   2012.12

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  • Molecular basis of chronopharmaceutics

    Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.

    J Pharm Sci   2011.9

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  • Chronopharmacology

    Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.

    Nihon Yakurigaku Zasshi   2011.5

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  • Asthma: Chronopharmacotherapy and the molecular clock

    Burioka N, Fukuoka Y, Koyanagi S, Miyata M, Takata M, Chikumi H, Takane H, Watanabe M, Endo M, Sako T, Suyama H, Ohdo S, Shimizu E

    Adv Drug Deliv Rev.   2010.6

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  • 時間薬物動態

    小柳悟、松永直哉、大戸茂弘

    医薬ジャーナル   2009.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計の分子機構を基盤にした抗がん剤の創薬・育薬研究

    小柳 悟

    時間生物学   2009.6

  • 生体リズムとDDS

    松永直哉、小柳悟、大戸茂弘

    医薬ジャーナル   2009.3

  • 創薬・育薬を指向した薬効評価学的研究および時間薬剤学的研究

    大戸茂弘、小柳悟、松永直哉

    薬剤学   2008.5

  • インターフェロンの時間薬理学的研究

    大戸茂弘, 小柳 悟

    臨床薬理の進歩   2004.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 血管内皮増殖因子の発現リズムを指標にした血管新生阻害薬の至適投薬タイミング設定

    小柳 悟, 大戸茂弘, 添田秦司, 占野廣司

    臨床薬理の進歩   2004.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体リズムを基盤にした医薬品の適正使用に関する臨床生化学的研究

    小柳 悟

    薬学雑誌   2003.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 時間薬理学:生体リズムを考慮した薬物療法

    小柳 悟, 大戸茂弘, 高根 浩, 樋口 駿

    1999.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Industrial property rights

Patent   Number of applications: 2   Number of registrations: 1
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Japanese Society for Alternatives to Animal Experiments

  • 日本薬剤学会

  • 日本臨床薬理学会

  • The Japanese Pharmacological Society

  • 日本毒性学会

  • 日本時間生物学会

  • 日本薬物動態学会

  • 日本薬学会

▼display all

Committee Memberships

  • Steering committee member   Domestic

    2024.1 - 2025.12   

  • 日本薬物動態学会   代議員   Domestic

    2024.1 - 2025.12   

  • Councilor   Domestic

    2011.4 - 2022.11   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2023

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

  • プログラム委員

    日本薬物動態学会第37回年会  ( 横浜市 ) 2022.11

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    Type:Competition, symposium, etc. 

    Number of participants:700

  • 運営委員/プログラム委員

    第27回日本時間生物学会学術大会  ( 那覇市 ) 2021.11

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • プログラム委員

    日本薬物動態学会第36回年会  ( 高崎市 ) 2021.11

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    Type:Competition, symposium, etc. 

    Number of participants:700

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • 事務局長・運営委員

    第41回日本臨床薬理学会学術総会  ( 福岡 ) 2020.12

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    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 運営委員

    日本薬剤学会 第35回年会  ( 熊本 ) 2020.5

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    Type:Competition, symposium, etc. 

    Number of participants:1,000

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:17

  • シンポジウム オーガナイザー・座長

    日本薬物動態学会第34回年会  ( つくば ) 2019.12

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    Type:Competition, symposium, etc. 

    Number of participants:150

  • シンポジウム オーガナイザー・座長

    第92回日本薬理学会学術大会  ( 大阪市 ) 2019.3

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    Type:Competition, symposium, etc. 

    Number of participants:500

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • 大会組織委員

    第25回日本時間生物学会学術大会  ( 長崎市 ) 2018.10

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • シンポジウム オーガナイザー・座長

    第25回日本時間生物学会学術大会  ( 長崎市 ) 2018.10

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

    Number of peer-reviewed articles in Japanese journals:1

  • シンポジウム オーガナイザー・座長

    医療薬学フォーラム2017 第25回クリニカルファーマシーシンポジウム  ( 鹿児島市 ) 2017.7

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    Type:Competition, symposium, etc. 

    Number of participants:1,500

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

    Number of peer-reviewed articles in Japanese journals:2

  • 事務局長

    日本動物実験代替法学会 第28回大会  ( 福岡市 ) 2016.11

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    Type:Competition, symposium, etc. 

    Number of participants:500

  • シンポジウム オーガナイザー・座長 International contribution

    日本動物実験代替法学会 第28回大会  ( 福岡市 ) 2016.11

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    Type:Competition, symposium, etc. 

    Number of participants:500

  • 日本時間生物学会会誌

    2016.4 - Present

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:95

  • 組織委員 International contribution

    ( 京都文化会館 ) 2015.10 - 2016.6

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    Type:Competition, symposium, etc. 

    Number of participants:180

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Number of peer-reviewed articles in Japanese journals:2

  • 事務局長

    第21回日本時間生物学会学術大会  ( 九州大学百年記念講堂 ) 2014.11

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • Screening of academic papers

    Role(s): Peer review

    2014

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:120

  • 組織委員(学会事務局長)

    医療薬学フォーラム2012/第20回クリニカルファーマシーシンポジム  ( 福岡国際会議場 ) 2012.7

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    Type:Competition, symposium, etc. 

    Number of participants:2,000

  • 開催事務局

    第3回次世代を担う若手医療薬科学シンポジウム  ( 福岡:九州大学 ) 2009.11

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    Type:Competition, symposium, etc. 

    Number of participants:200

▼display all

Research Projects

  • RNA編集の時刻変動を基軸にした時間薬剤学研究

    2023

    上原記念生命科学財団

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    Authorship:Principal investigator  Grant type:Contract research

  • カイコ昆⾍モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022.12 - 2026.4

      More details

    Authorship:Coinvestigator(s) 

  • グリーンファルマ創薬構造解析による支援高度化の推進

    2022.11 - 2026.4

      More details

    Authorship:Coinvestigator(s) 

  • がん突発痛の概日性発症メカニズムを基盤にした鎮痛標的分子の探索

    Grant number:22K18375  2022 - 2024

    日本学術振興会  科学研究費助成事業  挑戦的研究(開拓)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 時計遺伝子の機能不全による「がん幹細胞」発生機序の解明と抗がん剤耐性克服法の開発

    Grant number:20K21484  2020 - 2021

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新規経皮吸収型製剤を目指した鎮痛薬に関する研究

    2018.7 - 2019.7

    共同研究

      More details

    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • RNA編集と概日リズム制御機構との統合解析による薬物体内動態の個体差要因の解明

    Grant number:18H04019  2018 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 薬物動態の日内変動に関する研究

    2017.4 - 2019.3

    共同研究

      More details

    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • グリーンファルマを基盤にした創薬オープンイノベーションの推進

    2017 - 2021

    日本医療研究開発機構 「薬等ライフサイエンス研究支援基盤事業」

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 足場タンパクに着目した薬物輸送トランスポーターの細胞膜局在における概日リズム制御

    Grant number:17K19493  2017 - 2018

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の分子機構を介した薬物代謝酵素CYP3A4の活性個人差の究明

    2017 - 2018

    内藤記念科学奨励金・研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 副腎皮質ホルモン作動性因子による神経障害痛の概日リズム制御と鎮痛標的としての評価

    Grant number:15H04765  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の機能強化によるがん予防法の開発

    Grant number:26670317  2014 - 2015

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Establishment of in vitro circadian clock system for evaluation of cell protecting mechanism against oncogenic transformation

    2013 - 2014

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 難治性がん疼痛の概日変動メカニズムを基盤にした鎮痛標的分子の探索

    Grant number:24390149  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 体内時計の活性化による成人性疾患の予防・治療法の開発

    Grant number:24650446  2012 - 2013

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Effect of Brand’s Essence of Chicken on the mammalian circadian system

    2009.10 - 2013.1

    受託研究

      More details

    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 分子時計を標的にした抗がん剤耐性克服法の開発

    2009 - 2010

    中冨健康科学振興財団 研究助成金

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    Authorship:Principal investigator  Grant type:Contract research

  • 抗リウマチ薬の時間薬物療法の確立

    2008 - 2010

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 血清成分を指標にした抗がん剤の時間治療の構築

    2008

    薬理研究会助成金

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    Authorship:Principal investigator  Grant type:Contract research

  • 時計遺伝子を指標にしたCYP3A4の活性予測

    2007 - 2008

    臨床薬理研究振興財団研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 腫瘍細胞動態の日内変動を考慮した抗がん薬の至適投薬タイミング設定法の構築

    2003

    上原生命科学財団研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • がん病態の日内変動に着目した抗腫瘍薬の時間薬物療法の構築

    2002

    武田科学研究振興財団 薬学奨励研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 血清中因子を指標にした血管新生阻害薬の至適投薬タイミング設定

    2001

    臨床薬理研究振興財団研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

▼display all

Class subject

  • 臨床研究演習

    2024.10 - 2025.3   Second semester

  • 実務実習プレ演習

    2024.10 - 2025.3   Second semester

  • 医療薬学実習IV(分担)

    2024.10 - 2025.3   Second semester

  • 臨床試験演習

    2024.10 - 2025.3   Second semester

  • 医療薬学研究

    2024.10 - 2024.12   Fall quarter

  • 免疫学B

    2024.10 - 2024.12   Fall quarter

  • 薬剤学Ⅱ

    2024.10 - 2024.12   Fall quarter

  • 薬物動態学ⅠB

    2024.6 - 2024.8   Summer quarter

  • 薬学基礎実習Ⅳ

    2024.6 - 2024.8   Summer quarter

  • 免疫学A

    2024.6 - 2024.8   Summer quarter

  • 薬物動態学ⅠB

    2024.6 - 2024.8   Summer quarter

  • 少人数セミナー(分担)

    2024.6 - 2024.8   Summer quarter

  • 医療薬学研究 英語講義

    2024.4 - 2025.3   Full year

  • 卒業研究

    2024.4 - 2025.3   Full year

  • 専門英語

    2024.4 - 2025.3   Full year

  • 医療薬学系英語講義

    2024.4 - 2025.3   Full year

  • 先端研究実験II

    2024.4 - 2025.3   Full year

  • 先端研究実験I

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 III

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 II

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究演習 I

    2024.4 - 2025.3   Full year

  • 先端医療薬学研究実験

    2024.4 - 2025.3   Full year

  • 先端研究指導実習

    2024.4 - 2025.3   Full year

  • 高度融合研究演習 II

    2024.4 - 2025.3   Full year

  • 高度融合研究演習 I

    2024.4 - 2025.3   Full year

  • 高度融合研究実験

    2024.4 - 2025.3   Full year

  • 医療薬学演習 I

    2024.4 - 2024.9   First semester

  • 医療薬学演習 II

    2024.4 - 2024.9   First semester

  • 薬剤・動態学

    2024.4 - 2024.6   Spring quarter

  • 薬剤学Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 薬物動態学ⅠA

    2024.4 - 2024.6   Spring quarter

  • 創薬科学総論 I

    2024.4 - 2024.6   Spring quarter

  • 薬学総論Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 実務実習プレ演習

    2023.10 - 2024.3   Second semester

  • 臨床研究演習

    2023.10 - 2024.3   Second semester

  • 臨床試験演習

    2023.10 - 2024.3   Second semester

  • 医療薬学実習IV(分担)

    2023.10 - 2024.3   Second semester

  • 薬剤学Ⅱ

    2023.10 - 2023.12   Fall quarter

  • 薬剤学Ⅱ

    2023.10 - 2023.12   Fall quarter

  • 医療薬学研究

    2023.10 - 2023.12   Fall quarter

  • 免疫学B

    2023.10 - 2023.12   Fall quarter

  • 医療薬学研究

    2023.10 - 2023.12   Fall quarter

  • 少人数セミナー(分担)

    2023.6 - 2023.8   Summer quarter

  • 薬物動態学ⅠB

    2023.6 - 2023.8   Summer quarter

  • 免疫学A

    2023.6 - 2023.8   Summer quarter

  • 薬物送達システム学

    2023.6 - 2023.8   Summer quarter

  • 薬物動態学ⅠB

    2023.6 - 2023.8   Summer quarter

  • 卒業研究

    2023.4 - 2024.3   Full year

  • 医療薬学研究 英語講義

    2023.4 - 2024.3   Full year

  • 高度融合研究実験

    2023.4 - 2024.3   Full year

  • 高度融合研究演習 I

    2023.4 - 2024.3   Full year

  • 高度融合研究演習 II

    2023.4 - 2024.3   Full year

  • 先端研究指導実習

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究実験

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 I

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 II

    2023.4 - 2024.3   Full year

  • 先端医療薬学研究演習 III

    2023.4 - 2024.3   Full year

  • 先端研究実験I

    2023.4 - 2024.3   Full year

  • 先端研究実験II

    2023.4 - 2024.3   Full year

  • 医療薬学系英語講義

    2023.4 - 2024.3   Full year

  • 専門英語

    2023.4 - 2024.3   Full year

  • 医療薬学演習 II

    2023.4 - 2023.9   First semester

  • 医療薬学演習 I

    2023.4 - 2023.9   First semester

  • 創薬科学総論 I

    2023.4 - 2023.6   Spring quarter

  • 薬物動態学ⅠA

    2023.4 - 2023.6   Spring quarter

  • 薬学総論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 薬剤・動態学

    2023.4 - 2023.6   Spring quarter

  • 薬剤・動態学

    2023.4 - 2023.6   Spring quarter

  • 薬学総論Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 臨床試験演習

    2022.10 - 2023.3   Second semester

  • 臨床研究演習

    2022.10 - 2023.3   Second semester

  • 医療薬学実習IV(分担)

    2022.10 - 2023.3   Second semester

  • 医療薬学研究

    2022.10 - 2022.12   Fall quarter

  • 薬剤学Ⅱ

    2022.10 - 2022.12   Fall quarter

  • 薬物動態学ⅠB

    2022.6 - 2022.8   Summer quarter

  • 少人数セミナー(分担)

    2022.6 - 2022.8   Summer quarter

  • 先端研究実験I

    2022.4 - 2023.3   Full year

  • 専門英語

    2022.4 - 2023.3   Full year

  • 実務実習プレ演習

    2022.4 - 2023.3   Full year

  • 卒業研究

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 III

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 II

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究演習 I

    2022.4 - 2023.3   Full year

  • 先端医療薬学研究実験

    2022.4 - 2023.3   Full year

  • 先端研究指導実習

    2022.4 - 2023.3   Full year

  • 高度融合研究演習 II

    2022.4 - 2023.3   Full year

  • 高度融合研究演習 I

    2022.4 - 2023.3   Full year

  • 高度融合研究実験

    2022.4 - 2023.3   Full year

  • 医療薬学系英語講義

    2022.4 - 2023.3   Full year

  • 医療薬学研究 英語講義

    2022.4 - 2023.3   Full year

  • 先端研究実験II

    2022.4 - 2023.3   Full year

  • 医療薬学演習 I

    2022.4 - 2022.9   First semester

  • 医療薬学演習 II

    2022.4 - 2022.9   First semester

  • 薬剤・動態学

    2022.4 - 2022.6   Spring quarter

  • 薬物動態学ⅠA

    2022.4 - 2022.6   Spring quarter

  • 薬学総論Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 創薬科学総論 I

    2022.4 - 2022.6   Spring quarter

  • 臨床試験演習

    2021.10 - 2022.3   Second semester

  • 医療薬学実習IV(分担)

    2021.10 - 2022.3   Second semester

  • 臨床研究演習

    2021.10 - 2022.3   Second semester

  • 薬剤学Ⅱ

    2021.10 - 2021.12   Fall quarter

  • 少人数セミナー(分担)

    2021.10 - 2021.12   Fall quarter

  • 先端研究実験I

    2021.4 - 2022.3   Full year

  • 専門英語

    2021.4 - 2022.3   Full year

  • 薬学特別実習

    2021.4 - 2022.3   Full year

  • 実務実習プレ演習

    2021.4 - 2022.3   Full year

  • アドバンスト実務実習

    2021.4 - 2022.3   Full year

  • 卒業研究

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 III

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 II

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究演習 I

    2021.4 - 2022.3   Full year

  • 先端医療薬学研究実験

    2021.4 - 2022.3   Full year

  • 先端研究指導実習

    2021.4 - 2022.3   Full year

  • 高度融合研究演習 II

    2021.4 - 2022.3   Full year

  • 高度融合研究演習 I

    2021.4 - 2022.3   Full year

  • 高度融合研究実験

    2021.4 - 2022.3   Full year

  • 医療薬学系英語講義

    2021.4 - 2022.3   Full year

  • 医療薬学研究 英語講義

    2021.4 - 2022.3   Full year

  • 先端研究実験II

    2021.4 - 2022.3   Full year

  • 医療薬学演習 I

    2021.4 - 2021.9   First semester

  • 医療薬学演習 II

    2021.4 - 2021.9   First semester

  • 薬剤・動態学

    2021.4 - 2021.6   Spring quarter

  • 創薬科学総論 I

    2021.4 - 2021.6   Spring quarter

  • 薬学総論 I

    2021.4 - 2021.6   Spring quarter

  • 医療薬学実習IV(分担)

    2020.10 - 2021.3   Second semester

  • 臨床試験演習

    2020.10 - 2021.3   Second semester

  • 少人数セミナー(分担)

    2020.10 - 2020.12   Fall quarter

  • 薬剤学Ⅱ

    2020.10 - 2020.12   Fall quarter

  • 医療薬学系英語講義

    2020.4 - 2021.3   Full year

  • 卒業研究

    2020.4 - 2021.3   Full year

  • アドバンスト実務実習

    2020.4 - 2021.3   Full year

  • 実務実習プレ演習

    2020.4 - 2021.3   Full year

  • 薬学特別実習

    2020.4 - 2021.3   Full year

  • 先端研究実験II

    2020.4 - 2021.3   Full year

  • 臨床研究演習

    2020.4 - 2021.3   Full year

  • 医療薬学研究 英語講義

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究実験

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 I

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 II

    2020.4 - 2021.3   Full year

  • 先端医療薬学研究演習 III

    2020.4 - 2021.3   Full year

  • 高度融合研究実験

    2020.4 - 2021.3   Full year

  • 高度融合研究演習 I

    2020.4 - 2021.3   Full year

  • 先端研究指導実習

    2020.4 - 2021.3   Full year

  • 高度融合研究演習 II

    2020.4 - 2020.9   First semester

  • 先端研究実験I

    2020.4 - 2020.9   First semester

  • 医療薬学演習 I

    2020.4 - 2020.9   First semester

  • 医療薬学演習 II

    2020.4 - 2020.9   First semester

  • 創薬科学総論 I

    2020.4 - 2020.6   Spring quarter

  • 薬剤・動態学

    2020.4 - 2020.6   Spring quarter

  • 薬学総論 I

    2020.4 - 2020.6   Spring quarter

  • 医療薬学実習IV(分担)

    2019.10 - 2020.3   Second semester

  • 薬剤学Ⅱ

    2019.10 - 2019.12   Fall quarter

  • 少人数セミナー(分担)

    2019.10 - 2019.12   Fall quarter

  • 先端研究実験I

    2019.4 - 2020.3   Full year

  • 薬学特別実習

    2019.4 - 2020.3   Full year

  • 実務実習プレ演習

    2019.4 - 2020.3   Full year

  • アドバンスト実務実習

    2019.4 - 2020.3   Full year

  • 卒業研究

    2019.4 - 2020.3   Full year

  • 医療薬学系英語講義

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 III

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 II

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究演習 I

    2019.4 - 2020.3   Full year

  • 先端医療薬学研究実験

    2019.4 - 2020.3   Full year

  • 先端研究指導実習

    2019.4 - 2020.3   Full year

  • 高度融合研究演習 II

    2019.4 - 2020.3   Full year

  • 高度融合研究演習 I

    2019.4 - 2020.3   Full year

  • 高度融合研究実験

    2019.4 - 2020.3   Full year

  • 医療薬学研究 英語講義

    2019.4 - 2020.3   Full year

  • 先端研究実験II

    2019.4 - 2020.3   Full year

  • 医療薬学演習 I

    2019.4 - 2019.9   First semester

  • 医療薬学演習 II

    2019.4 - 2019.9   First semester

  • 薬剤・動態学

    2019.4 - 2019.6   Spring quarter

  • 創薬科学総論 I

    2019.4 - 2019.6   Spring quarter

  • 医療薬学実習IV(分担)

    2018.10 - 2019.3   Second semester

  • 薬剤学Ⅱ

    2018.10 - 2018.12   Fall quarter

  • 少人数セミナー(分担)

    2018.10 - 2018.12   Fall quarter

  • 先端研究実験I

    2018.4 - 2019.3   Full year

  • 薬学特別実習

    2018.4 - 2019.3   Full year

  • 実務実習プレ演習

    2018.4 - 2019.3   Full year

  • アドバンスト実務実習

    2018.4 - 2019.3   Full year

  • 卒業研究

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 III

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 II

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究演習 I

    2018.4 - 2019.3   Full year

  • 先端医療薬学研究実験

    2018.4 - 2019.3   Full year

  • 先端研究指導実習

    2018.4 - 2019.3   Full year

  • 高度融合研究演習 II

    2018.4 - 2019.3   Full year

  • 高度融合研究演習 I

    2018.4 - 2019.3   Full year

  • 高度融合研究実験

    2018.4 - 2019.3   Full year

  • 医療薬学研究 英語講義

    2018.4 - 2019.3   Full year

  • 先端研究実験II

    2018.4 - 2019.3   Full year

  • 医療薬学演習 I

    2018.4 - 2018.9   First semester

  • 医療薬学演習 II

    2018.4 - 2018.9   First semester

  • 薬剤・動態学

    2018.4 - 2018.6   Spring quarter

  • 創薬科学総論 I

    2018.4 - 2018.6   Spring quarter

▼display all

FD Participation

  • 2023.11   Role:Participation   Title:機関間連携

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.3   Role:Participation   Title:第4回全学FD(TF 経験を通じて大学院生の教育能力を高める)

    Organizer:University-wide

  • 2022.11   Role:Participation   Title:アカデミア創薬

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role:Participation   Title:学生の多様性に対応した教育とは:障害学生への合理的配慮を中心に

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Role:Participation   Title:未来を拓く博士人材育成のためのオープンプラットフォーム型教育システムの構築

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.3   Role:Participation   Title:3ポリシーの見直し指針について

    Organizer:University-wide

  • 2018.10   Role:Participation   Title:平成30年度馬出地区4部局合同男女共同参画FD

    Organizer:University-wide

  • 2017.3   Role:Planning   Title:九州大学における情報セキュリティに関する取組

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.10   Role:Participation   Title:馬出地区キャンパスFD —男女共同参画の必要性と九州大学における取組み—

    Organizer:University-wide

  • 2016.5   Role:Participation   Title:外国人留学生の受入と管理(情報管理、輸出管理)について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.4   Role:Participation   Title:Webを用いた薬局実務実習記録書(電子ポートフォリオ)に関する説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.6   Role:Participation   Title:製薬業界の環境変化を受けた今後のMR活動とメディカルアフェアーズの確立について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.8   Role:Participation   Title:GPA制度を正しく活用して、教育の質向上を図る

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.3   Role:Participation   Title:学生のメンタルヘルスの現状と対応

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.4   Role:Participation   Title:薬局実習実施説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.10   Role:Participation   Title:OSCE評価者説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.5   Role:Participation   Title:第1 回 全学FD

    Organizer:University-wide

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2023  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2022  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2022  徳島大学・ 薬学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(1月)

  • 2021  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2020  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2019  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2018  長崎大学・歯学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2017  千葉大学大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(5月)

  • 2015  千葉大学大学院医学薬学府  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(5月)

  • 2015  早稲田大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(11月)

  • 2015  熊本大学大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期(1月)

  • 2013  富山大学医学薬学教育部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期(平成25年4月〜平成25年9月)

▼display all

Participation in international educational events, etc.

  • 2023.9

    陽明交通大学 薬学部(台湾)

    日本-台湾 薬学部 6大学ジョイントシンポジウム

      More details

    Venue:台北市

    Number of participants:200

  • 2020.9

    九州大学大学院薬学研究院

    ASIA WEEK2020(薬学国際ウェビナー)

      More details

    Number of participants:40

Other educational activity and Special note

  • 2022  Special Affairs 

  • 2022  Special Affairs 

  • 2021  Special Affairs 

  • 2021  Special Affairs 

  • 2020  Special Affairs 

  • 2019  Special Affairs 

  • 2018  Class Teacher 

  • 2018  Special Affairs 

  • 2017  Special Affairs 

  • 2016  Special Affairs 

▼display all

Outline of Social Contribution and International Cooperation activities

  • 福岡地区勤務薬剤会 生涯教育委員会

Social Activities

  • 体内時計を活用した創薬研究と疾患治療

    山口県立徳山高等学校  2024.3

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計と健康・病気のリズム

    福岡市薬剤師会  福岡市薬剤師会館  2024.1

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Cardinal training 「添付文書から薬の特徴・薬物動態を知る」

    福岡市薬剤師会  福岡市薬剤師会館  2022.3

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 平成21年度明善高校大学セミナー

    福岡県立明善高等学校  2021.6

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 身体のリズムと薬物治療

    福岡市薬剤師会  福岡市薬剤師会館  2021.3

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 身体のリズムと がん・慢性疼痛の薬物治療

    福岡市薬剤師会  福岡市薬剤師会館  2019.11

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 九州大学について

    福岡県立鞍手高等学校  2019.3

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 社会における薬学研究の役割

    明治学園高校・中学校  2018.7

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計研究の進展と医療・創薬への応用

    平成27年度九州大学薬学研究院公開講座  九州大学コラボステーション  2017.6

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 平成23年度明善高校大学セミナー

    福岡県立明善高等学校  2011.12

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 平成22年度明善高校大学セミナー:薬学部6年制と4年制学科の現状と今後について

    福岡県立明善高等学校  2010.12

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • TDMセミナー(抗がん剤、免疫抑制剤のTDM)

    福岡地区勤務薬剤師会  イムズホール  2010.10

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 濟々未来講座:薬学部4年制と6年制の現状と今後

    熊本県立濟々黌高等学校  2010.10

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 体内時計と薬の効果・毒性のリズム

    身近な毒に強くなる会  九州大学西新交流プラザ  2010.9

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 時計遺伝子のはたらきと薬の効果のリズム

    平成22年度九州大学薬学研究院公開講座  九州大学コラボステーション  2010.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九州大学薬学部の創薬科学科と臨床薬学科について

    熊本県立熊本高等学校  2010.6

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学薬学部の4年制と6年制の学科について

    熊本県立濟々黌高等学校  2010.6

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 新型インフルエンザのパンデミックは起こり得るのか?

    身近な毒に強くなる会  九州大学西新交流プラザ  2009.2

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Basic Study研修会 ホルモン全般について(2)

    福岡市薬剤師会  福岡市薬剤師会館  2008.4

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • Basic Study研修会 ホルモン全般について(1)

    福岡市薬剤師会  福岡市薬剤師会館  2008.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • リン酸オセミタビルの効果と副作用について

    身近な毒に強くなる会  九州大学西新交流プラザ  2007.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 体内時計の働きと病気のリズム

    東明館高校  2007.6

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 時間治療 〜体内時計の働きと疾患・薬効のリズム〜

    臨床薬理学会  大分県・別府市  2005.12

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 体内時計の分子機構を基盤にしたガンの時間治療

    大阪薬科大学  大阪府・高槻市  2005.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 体内時計の働きと病気のリズム

    福岡大学  福岡市  2002.5

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

▼display all

Media Coverage

  • 薬をのむ「最適時間」がわかった Newspaper, magazine

    文芸春秋  2017.10

     More details

    薬をのむ「最適時間」がわかった

  • 神経障害性疼痛 痛みの強さ時間帯で変化 仕組み解明 TV or radio program

    NHKニュース  2016.10

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    神経障害性疼痛 痛みの強さ時間帯で変化 仕組み解明

  • 時間帯で痛み変化 九大が仕組み解明 Newspaper, magazine

    読売新聞  2016.10

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    時間帯で痛み変化 九大が仕組み解明

  • 神経性の痛み 時刻で変化 〜九大チーム、仕組み解明〜 Newspaper, magazine

    朝日新聞  2016.10

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    神経性の痛み 時刻で変化 〜九大チーム、仕組み解明〜

  • 「からだの時計」が医療を変える TV or radio program

    NHK総合テレビ「クローズアップ現代」  2012.4

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    「からだの時計」が医療を変える

  • 不明 Newspaper, magazine

    2005.6

  • 薬を飲む時間に要注意!知られざる生体リズムとの関係 TV or radio program

    NHK教育テレビ「サイエンスアイ」  1998.5

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    薬を飲む時間に要注意!知られざる生体リズムとの関係

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Acceptance of Foreign Researchers, etc.

  • 台北医学大学

    Acceptance period: 2019.1 - 2019.2   (Period):2weeks to less than 1 month

    Nationality:Taiwan, Province of China

    Business entity:On-campus funds

  • Chulalongkorn University

    Acceptance period: 2018.6 - 2018.7   (Period):2weeks to less than 1 month

    Nationality:Thailand

    Business entity:On-campus funds

Travel Abroad

  • 2019.4

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:國立陽明大學

  • 2019.4

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:台北医学大学

  • 2018.9

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:台北医学大学

  • 2018.1

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:Taipei Medical University