Updated on 2024/07/28

Information

 

写真a

 
MAKOTO TSUDA
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Professor
Faculty of Pharmaceutical Sciences Drug Discovery and Evolution Center(Joint Appointment)
School of Pharmaceutical Sciences Department of Clinical Pharmacy(Joint Appointment)
Graduate School of Pharmaceutical Sciences Department of Clinical Pharmacy(Joint Appointment)
Graduate School of Pharmaceutical Sciences Department of Medicinal Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Profile
Outline of research: Molecular and cellular mechanisms in the peripheral and central nervous system underlying chronic pain and itch focusing on the role of glial cells. Education: Pharmacology, Seminar, Medicine, Neuropharmacology
Homepage
  • http://life-innov.phar.kyushu-u.ac.jp/index-e.html

    Work in my laboratory is primarily directed to elucidating glia-neuron interactions in the spinal cord and brain and to understanding the cellular and molecular mechanisms of pain and itch signaling (in particular pathological chronic pain and itch). Our work employs several cutting-edge genetic tools to manipulate the specific type of cells to determine how identifiable populations of neurons and glial cells contribute to pain and itch behaviors in a causal manner. We also complementally use electrophysiology and cellular functional imaging (in vitro and in vivo) to measure activity of neurons and glial cells. From these studies, we devise strategies for new types of pain and itch relieving medications.

Degree

  • Ph.D.

Research History

  • 科学技術振興事業団 特別研究員(国立医薬品食品衛生研究所配属) 医薬品副作用被害救済・研究振興調査機構 派遣研究員(国立医薬品食品衛生研究所配属) 厚生労働省 厚生労働技官(国立医薬品食品衛生研究所配属)

    科学技術振興事業団 特別研究員(国立医薬品食品衛生研究所配属) 医薬品副作用被害救済・研究振興調査機構 派遣研究員(国立医薬品食品衛生研究所配属) 厚生労働省 厚生労働技官(国立医薬品食品衛生研究所配属)

  • 奈良県立医科大学 非常勤講師 順天堂大学大学院環境医学研究所 客員教授

Research Interests・Research Keywords

  • Research theme:Molecular and cellular mechanisms of itch

    Keyword:itch, spinal cord, neurons, glia, primary afferent sensory neurons

    Research period: 2012.4

  • Research theme:Studies on mechanisms underlying the development and maintenance of intractable pain

    Keyword:neuropathic pain, ATP receptors, intracellular signal transduction, glial cells

    Research period: 1999.4

Awards

  • 令和6年度科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)

    2024.4   文部科学省   グリア細胞を軸とした疼痛の発症と慢性化機序に関する研究

  • 第37回井上学術賞

    2021.2   公益財団法人 井上科学振興財団   グリア細胞による体性感覚(痛みと痒み)制御機構に関する研究

  • Excellent Presentation Award

    2019.11  

  • 日本薬学会学術振興賞

    2019.3   日本薬学会   神経障害性疼痛におけるミクログリア細胞の役割に関する研究

  • 平成25年度九州大学研究活動表彰

    2013.11   九州大学   研究代表者としての競争的研究資金の獲得額が3千万円以上となったため

  • 平成24年度九州大学研究活動表彰

    2012.11   九州大学   研究代表者としての競争的研究資金の獲得額が3千万円以上となったため

  • Best Poster Award

    2012.6   The 7th International Conference of Neurons and Brain Diseases   IRF8 is a critical transcription for transforming microglia into a reactive phenotype

  • 平成23年度九州大学研究活動表彰

    2011.11   九州大学   研究代表者としての競争的研究資金の獲得額が3千万円以上となったため

  • Best Poster Award

    2008.8   The 3rd International Conference of Neurons and Brain Disease  

  • 平成19年度日本神経化学会奨励賞(最優秀賞)

    2007.9   日本神経化学会   「脊髄ミクログリアを介する神経因性疼痛の発症維持メカニズム」

  • 平成19年度文部科学大臣表彰若手科学者賞

    2007.4   文部科学省   「生命科学分野における疼痛発症維持機構の研究」

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    「生命科学分野における疼痛発症維持機構の研究」
    癌や糖尿病患者などで見られる神経障害性の慢性疼痛は,モルヒネが著効しない難治性の痛みである。その発症機序は不明で,有効な治療薬もない。従来までの研究は,神経障害性ゆえに,神経細胞での変化のみに注目してきたが,未だ疼痛を制圧するには至っていない。津田誠氏は,難治性疼痛動物モデルの脊髄において,ATP受容体(細胞外ATPの受容体)の一つであるP2X4受容体が,非神経細胞のミクログリアに過剰発現し,その活性化が疼痛の原因であることを世界で初めて発見した。さらに,P2X4受容体刺激後にミクログリアから放出される疼痛因子も特定した。本研究成果は,難治性疼痛におけるミクログリアの重要性を明示したことで,その発症維持機序の解明に大きな前進をもたらし,今後のミクログリア発現分子を標的とした治療薬開発にも繋がると期待される。

  • 第22回日本薬理学会学術奨励賞

    2007.3   日本薬理学会   ATP受容体を介した難治性疼痛発症維持機構

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Papers

  • Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Reviewed International journal

    Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F Worley, Makoto Tsuda

    Nature communications   13 ( 1 )   2367 - 2367   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-022-30089-x

  • A spinal microglia population involved in remitting and relapsing neuropathic pain. Reviewed International journal

    Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, Keiko Takanami, Kazuhide Inoue, Hirotaka Sakamoto, Yasuyuki Ohkawa, Takahiro Masuda, Makoto Tsuda

    Science (New York, N.Y.)   376 ( 6588 )   86 - 90   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.abf6805

  • A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. Reviewed International journal

    Ryoichi Tashima, Keisuke Koga, Yu Yoshikawa, Misuzu Sekine, Moeka Watanabe, Hidetoshi Tozaki-Saitoh, Hidemasa Furue, Toshiharu Yasaka, Makoto Tsuda

    Proceedings of the National Academy of Sciences of the United States of America   118 ( 3 )   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.2021220118

  • Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity. Reviewed International journal

    Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Keita Kohno, Keisuke Koga, Ryuichi Katsuragi, Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Shota Okada, Kazuya Momokino, Aogu Furusho, Kenji Hamase, Takumi Oti, Hirotaka Sakamoto, Kenichiro Hayashida, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

    Nature neuroscience   23 ( 11 )   1376 - 1387   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41593-020-00713-4

  • Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor Reviewed International journal

    Keisuke Koga, Ryo Yamagata, Keita Kohno, Takuya Yamane, Miho Shiratori-Hayashi, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Makoto Tsuda

    Journal of Allergy and Clinical Immunology   145 ( 1 )   183 - 191.e10   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2019.09.034

  • Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor. Reviewed International journal

    Keisuke Koga, Ryo Yamagata, Keita Kohno, Takuya Yamane, Miho Shiratori-Hayashi, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Makoto Tsuda

    The Journal of allergy and clinical immunology   145 ( 1 )   183 - 191   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2019.09.034

  • Role of P2X3 receptors in scratching behavior in mouse models Reviewed International journal

    Shiratori-Hayashi M, Hasegawa A, Toyonaga H, Andoh T, Nakahara T, Kido-Nakahara M, Furue M, Kuraishi Y, Inoue K, Dong X, Tsuda M

    J Allergy Clin Immunol   143 ( 3 )   1252 - 1254.e8   2019.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaci.2018.10.053

  • Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats. Reviewed International journal

    5   ENEURO.0450-17.2018   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/ENEURO.0450-17.2018

  • Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain Reviewed International journal

    Masuda T et al.

    Nat Commun   7   12529   2016.8

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  • Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury Reviewed International journal

    Tashima R et al.

    Sci Rep   6   23701   2016.3

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  • A new minimally-invasive method for microinjection into the mouse spinal dorsal horn Reviewed International journal

    Yuta Kohro et al.

    Sci Rep   5   14306   2015.9

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  • STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch Reviewed International journal

    Miho Shiatori-Hayashi et al.

    NATURE MEDICINE   21 ( 8 )   927 - 931   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.3912

  • Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain. Reviewed International journal

    Matsushita K et al.

    Anesthesiology   120 ( 6 )   1491 - 1503   2014.6

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  • Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain. Reviewed International journal

    Masuda Takahiro et al.

    Nat Commun   5   3771   2014.5

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  • IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype Reviewed International journal

    Masuda Takahiro, TSUDA MAKOTO, Ryohei Yoshinaga, Hidetoshi Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inoue

    CELL REPORTS   1 ( 4 )   334 - 340   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2012.02.014

  • Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. Reviewed International journal

    Biber K*, Tsuda M*, Tozaki-Saitoh H*, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. (*equal contributors)

    EMBO J   30 ( 9 )   2011.5

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  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Reviewed International journal

    Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K

    Brain   134 ( 4 )   2011.4

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  • Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways Reviewed International journal

    Tsuda M, Toyomitsu E, Kometani M, Tozaki-Saitoh H, Inoue K

    J Cell Mol Med   13 ( 9b )   2009.9

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  • Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays Reviewed International journal

    Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K

    Mol Pain   5   2009.6

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  • IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain Reviewed International journal

    Tsuda M, Masuda T, Kitano J, Shimoyama H, Tozaki-Saitoh H, Inoue K

    Proc Natl Acad Sci U S A   106 ( 19 )   2009.5

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  • Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors Reviewed International journal

    Shinozaki Y, Sumitomo K, Tsuda M, Koizumi S, Inoue K, Torimitsu K

    PLoS Biol   7 ( 5 )   2009.5

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  • P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury Reviewed International journal

    Tozaki-Saitoh H, Tsuda M, Miyata H, Ueda K, Kohsaka S, Inoue K

    J Neurosci 28: 4949-4956 (2008)   2008.5

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  • Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury Reviewed International journal

    Tsuda M, Toyomitsu E, Komatsu T, Masuda T, Kunifusa E, Nasu-Tada K, Koizumi S, Yamamoto K, Ando J, Inoue K

    Glia 56: 579-585 (2008)   2008.4

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  • Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling Reviewed International journal

    Tsuda M, Ueno H, Kataoka A, Tozaki-Saitoh H, Inoue K

    Glia 56: 378-386 (2008)   2008.3

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  • Tsuda M, Tozaki-Saitoh H, Masuda T, Toyomitsu E, Tezuka T, Yamamoto T, Inoue K Reviewed International journal

    Lyn tyrosine kinase is required for P2X4 receptor upregulation and neuropathic pain after peripheral nerve injury

    Glia 56: 50-58 (2008)   2008.1

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  • P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain Reviewed International journal

    Tsuda M, Hasegawa S, Inoue K

    J Neurochem 103: 1408-1416 (2007)   2007.11

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  • UDP acting at P2Y(6) receptors is a mediator of microglial phagocytosis. Reviewed International journal

    Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K.

    Nature. 446: 1091-1095 (2007)   2007.4

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  • Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Reviewed International journal

    2006.5

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  • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Reviewed International journal

    Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y.

    Nature. 2005 Dec 15;438(7070):1017-21.   438 ( 7070 )   1017 - 1021   2005.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature04223

  • Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Reviewed International journal

    Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K.

    Glia. 2004 Jan 1;45(1):89-95.   45 ( 1 )   89 - 95   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/glia.10308

  • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Reviewed International journal

    Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K. Related Articles, Links

    Nature. 2003 Aug 14;424(6950):778-83.   424 ( 6950 )   778 - 783   2003.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature01786

  • Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. Reviewed International journal

    Tsuda M, Koizumi S, Kita A, Shigemoto Y, Ueno S, Inoue K.

    J Neurosci. 2000 Aug 1;20(15):RC90.   20 ( 15 )   2000.8

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  • Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict

    Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Anthony E. Pickering, Hidemasa Furue

    Communications Biology   7 ( 1 )   2024.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-024-06008-9

  • Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. International journal

    Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima

    Scientific reports   13 ( 1 )   11177 - 11177   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-38301-8

  • Microglial diversity in neuropathic pain

    Makoto Tsuda, Takahiro Masuda, Keita Kohno

    Trends in Neurosciences   46 ( 7 )   597 - 610   2023.7

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    DOI: 10.1016/j.tins.2023.05.001

  • Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury Reviewed

    16   2023.3

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    Neuropathic pain, an intractable pain symptom that occurs after nerve damage, is caused by the aberrant excitability of spinal dorsal horn (SDH) neurons. Gabapentinoids, the most commonly used drugs for neuropathic pain, inhibit spinal calcium-mediated neurotransmitter release by binding to α2δ-1, a subunit of voltage-gated calcium channels, and alleviate neuropathic pain. However, the exact contribution of α2δ-1 expressed in SDH neurons to the altered synaptic transmission and mechanical hypersensitivity following nerve injury is not fully understood. In this study, we investigated which types of SDH neurons express α2δ-1 and how α2δ-1 in SDH neurons contributes to the mechanical hypersensitivity and altered spinal synaptic transmission after nerve injury. Using in situ hybridization technique, we found that Cacna2d1, mRNA coding α2δ-1, was mainly colocalized with Slc17a6, an excitatory neuronal marker, but not with Slc32a1, an inhibitory neuronal marker in the SDH. To investigate the role of α2δ-1 in SDH neurons, we used clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system and showed that SDH neuron-specific ablation of Cacna2d1 alleviated mechanical hypersensitivity following nerve injury. We further found that excitatory post-synaptic responses evoked by electrical stimulation applied to the SDH were significantly enhanced after nerve injury, and that these enhanced responses were significantly decreased by application of mirogabalin, a potent α2δ-1 inhibitor, and by SDH neuron-specific ablation of Cacna2d1. These results suggest that α2δ-1 expressed in SDH excitatory neurons facilitates spinal nociceptive synaptic transmission and contributes to the development of mechanical hypersensitivity after nerve injury.

    DOI: 10.3389/fnmol.2023.1099925

  • GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice. Reviewed International journal

    Teruaki Ono, Tomohiro Yamashita, Ryota Kano, Mariko Inoue, Shota Okada, Koki Kano, Schuichi Koizumi, Kazuhisa Iwabuchi, Yoshio Hirabayashi, Ichiro Matsuo, Yasuharu Nakashima, Hiroyuki Kamiguchi, Yuta Kohro, Makoto Tsuda

    Brain, behavior, and immunity   110   276 - 287   2023.3

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    DOI: 10.1016/j.bbi.2023.03.008

  • IP3R1-dependent astrocyte calcium signaling in chronic itch

    Miho Shiratori-Hayashi, Makoto Tsuda

    Neuroscience Research   187   40 - 44   2023.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2022.09.013

  • Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. International journal

    Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima

    Research square   2023.1

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    Language:English  

    DOI: 10.21203/rs.3.rs-2427082/v1

  • Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats. Reviewed International journal

    Tadayuki Ishibashi, Daichi Sueto, Yu Yoshikawa, Keisuke Koga, Ken Yamaura, Makoto Tsuda

    Cells   11 ( 24 )   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cells11244051

  • Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour. Reviewed International journal

    Ikuko Takeda, Kohei Yoshihara, Dennis L Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J Moorhouse, Junichi Nabekura

    Nature communications   13 ( 1 )   4100 - 4100   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-022-31773-8

  • Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats

    15   2022.6

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    Mechanical allodynia (pain produced by innocuous stimuli such as touch) is the main symptom of neuropathic pain. Its underlying mechanism remains to be elucidated, but peripheral nerve injury (PNI)-induced malfunction of neuronal circuits in the central nervous system, including the spinal dorsal horn (SDH), is thought to be involved in touch-pain conversion. Here, we found that intra-SDH injection of adeno-associated viral vectors including a prodynorphin promoter (AAV-PdynP) captured a subset of neurons that were mainly located in the superficial laminae, including lamina I, and exhibited mostly inhibitory characteristics. Using transgenic rats that enable optogenetic stimulation of touch-sensing Aβ fibers, we found that the light-evoked paw withdrawal behavior and aversive responses after PNI were attenuated by selective ablation of AAV-PdynP-captured SDH neurons. Notably, the ablation had no effect on withdrawal behavior from von Frey filaments. Furthermore, Aβ fiber stimulation did not excite AAV-PdynP+ SDH neurons under normal conditions, but after PNI, this induced excitation, possibly due to enhanced Aβ fiber-evoked excitatory synaptic inputs and elevated resting membrane potentials of these neurons. Moreover, the chemogenetic silencing of AAV-PdynP+ neurons of PNI rats attenuated the Aβ fiber-evoked paw withdrawal behavior and c-FOS expression in superficial SDH neurons. Our findings suggest that PNI renders AAV-PdynP-captured neurons excitable to Aβ fiber stimulation, which selectively contributes to the conversion of Aβ fiber-mediated touch signal to nociceptive. Thus, reducing the excitability of AAV-PdynP-captured neurons may be a new option for the treatment of neuropathic allodynia.

    DOI: 10.3389/fnmol.2022.911122

  • Chemogenetic silencing of spinal cord-projecting cortical neurons attenuates Aβ fiber-derived neuropathic allodynia in mice. Reviewed International journal

    2022.5

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    Mechanical allodynia (pain caused by innocuous mechanical stimulation) is a hallmark symptom of neuropathic pain occurring following peripheral nerve injury (PNI). Using a transgenic mouse line, in which myelinated primary afferents, including Aβ fibers, express channelrhodopsin-2, we found that illumination of the plantar skin of mice following PNI produced an Aβ fiber-mediated pain-like withdrawal behavior and increased c-FOS+ neurons in the superficial spinal dorsal horn (SDH). These two responses were attenuated by chemogenetic silencing of primary sensory cortex (S1) neurons projecting directly to the SDH. These findings indicate that spinally projecting cortical S1 neurons contribute to Aβ fiber-derived neuropathic allodynia.

    DOI: 10.1016/j.neures.2022.05.001

  • Specification of CNS macrophage subsets occurs postnatally in defined niches. Reviewed International journal

    Nature   604 ( 7907 )   740 - 748   2022.4

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    DOI: 10.1038/s41586-022-04596-2

  • The Function of Glial Cells in the Neuroinflammatory and Neuroimmunological Responses. Reviewed International journal

    Ruqayya Afridi, Makoto Tsuda, Hoon Ryu, Kyoungho Suk

    Cells   11 ( 4 )   2022.2

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    DOI: 10.3390/cells11040659

  • Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice. Reviewed International journal

    15 ( 1 )   6 - 6   2022.1

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    It is well known that acute exposure to physical stress produces a transient antinociceptive effect (called stress-induced analgesia [SIA]). One proposed mechanism for SIA involves noradrenaline (NA) in the central nervous system. NA has been reported to activate inhibitory neurons in the spinal dorsal horn (SDH), but its in vivo role in SIA remains unknown. In this study, we found that an antinociceptive effect on noxious heat after acute exposure to restraint stress was impaired in mice with a conditional knockout of α1A-adrenaline receptors (α1A-ARs) in inhibitory neurons (Vgat-Cre;Adra1aflox/flox mice). A similar reduction was also observed in mice treated with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, a selective neurotoxin for NAergic neurons in the locus coeruleus (LC). Furthermore, whole-cell patch-clamp recordings using spinal cord slices revealed that NA-induced increase in the frequency of spontaneous inhibitory postsynaptic currents in the substantia gelatinosa neurons was suppressed by silodosin, an α1A-AR antagonist, and by conditional knockout of α1A-ARs in inhibitory neurons. Moreover, under unstressed conditions, the antinociceptive effects of intrathecal NA and phenylephrine on noxious heat were lost in Vgat-Cre;Adra1aflox/flox mice. Our findings suggest that activation of α1A-ARs in SDH inhibitory neurons, presumably via LC-NAergic neurons, is necessary for SIA to noxious heat.

    DOI: 10.1186/s13041-021-00895-3

  • Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions. Reviewed International journal

    Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, Makoto Tsuda, Tadashi Ueda

    Scientific reports   12 ( 1 )   131 - 131   2022.1

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    DOI: 10.1038/s41598-021-03784-w

  • Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling. International journal

    Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda

    Molecular brain   14 ( 1 )   79 - 79   2021.5

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    DOI: 10.1186/s13041-021-00788-5

  • α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice. Reviewed International journal

    14 ( 1 )   55 - 55   2021.3

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    Our previous study showed the intrinsic ability of descending noradrenergic neurons projecting from the locus coeruleus to the spinal dorsal horn (SDH) to suppress itch-related behaviors. Noradrenaline and α1A-adrenaline receptor (α1A-AR) agonist increase inhibitory synaptic inputs onto SDH interneurons expressing gastrin-releasing peptide receptors, which are essential for itch transmission. However, the contribution of α1A-ARs expressed in SDH inhibitory interneurons to itch-related behavior remains to be determined. In this study, RNAscope in situ hybridization revealed that Adra1a mRNA is expressed in SDH inhibitory interneurons that are positive for Slc32a1 mRNA (known as vesicular GABA transporter). Mice with conditional knock-out of α1A-ARs in inhibitory interneurons (Vgat-Cre;Adra1aflox/flox mice) exhibited an increase in scratching behavior when induced by an intradermal injection of chloroquine, but not compound 48/80, which are known as models of histamine-independent and dependent itch, respectively. Furthermore, knockout of inhibitory neuronal α1A-ARs in the SDH using the CRISPR-Cas9 system also increased the scratching behavior elicited by chloroquine but not compound 48/80. Our findings demonstrated for the first time that α1A-ARs in SDH inhibitory interneurons contribute to the regulation of itch signaling with preference for histamine-independent itch.

    DOI: 10.1186/s13041-021-00768-9

  • A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice. Reviewed International journal

    Shuntaro Uchida, Shingo Soya, Yuki C Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai

    The Journal of neuroscience : the official journal of the Society for Neuroscience   41 ( 7 )   1582 - 1596   2021.2

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    DOI: 10.1523/JNEUROSCI.0688-20.2020

  • New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain. Reviewed International journal

    10 ( 2 )   2021.2

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    P2X7 receptors (P2X7Rs) belong to a family of ATP-gated non-selective cation channels. Microglia represent a major cell type expressing P2X7Rs. The activation of microglial P2X7Rs causes the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β). This response has been implicated in neuroinflammatory states in the central nervous system and in various diseases, including neuropathic pain. Thus, P2X7R may represent a potential therapeutic target. In the present study, we screened a chemical library of clinically approved drugs (1979 compounds) by high-throughput screening and showed that the Ca2+ channel blocker cilnidipine has an inhibitory effect on rodent and human P2X7R. In primary cultured rat microglial cells, cilnidipine inhibited P2X7R-mediated Ca2+ responses and IL-1β release. Moreover, in a rat model of neuropathic pain, the intrathecal administration of cilnidipine produced a reversal of nerve injury-induced mechanical hypersensitivity, a cardinal symptom of neuropathic pain. These results point to a new inhibitory effect of cilnidipine on microglial P2X7R-mediated inflammatory responses and neuropathic pain, proposing its therapeutic potential.

    DOI: 10.3390/cells10020434

  • Reply to Letter to the Editor "Regarding letter on mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6". Reviewed International journal

    Teruaki Ono, Makoto Tsuda

    Brain, behavior, and immunity   91   796 - 796   2021.1

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    DOI: 10.1016/j.bbi.2020.11.014

  • Analysis of binding residues in monoclonal antibody with high affinity for the head domain of the rat P2X4 receptor. Reviewed International journal

    Tatsuhiro Igawa, Shuhei Kishikawa, Yoshito Abe, Makoto Tsuda, Kazuhide Inoue, Tadashi Ueda

    Journal of biochemistry   2020.11

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    DOI: 10.1093/jb/mvaa124

  • Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions. Reviewed

    Miho Shiratori-Hayashi, Makoto Tsuda

    Journal of pharmacological sciences   144 ( 3 )   147 - 150   2020.11

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    DOI: 10.1016/j.jphs.2020.07.010

  • Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors. Reviewed International journal

    Kazuhide Inoue, Makoto Tsuda

    Biochemical pharmacology   114309 - 114309   2020.10

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    DOI: 10.1016/j.bcp.2020.114309

  • Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice. Reviewed International journal

    Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi, Makoto Tsuda

    Molecular brain   13 ( 1 )   144 - 144   2020.10

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    DOI: 10.1186/s13041-020-00688-0

  • Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. Reviewed International journal

    Hiroyuki Konishi, Takayuki Okamoto, Yuichiro Hara, Okiru Komine, Hiromi Tamada, Mitsuyo Maeda, Fumika Osako, Masaaki Kobayashi, Akira Nishiyama, Yosky Kataoka, Toshiyuki Takai, Nobuyuki Udagawa, Steffen Jung, Keiko Ozato, Tomohiko Tamura, Makoto Tsuda, Koji Yamanaka, Tomoo Ogi, Katsuaki Sato, Hiroshi Kiyama

    The EMBO journal   e104464   2020.9

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    DOI: 10.15252/embj.2020104464

  • The liver-brain-gut neural arc maintains the Treg cell niche in the gut. Reviewed International journal

    Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Takahiro Suzuki, Yosuke Harada, Koji Okabayashi, Yuya Hagihara, Nobuhito Taniki, Keita Kohno, Shinsuke Shibata, Kentaro Miyamoto, Harumichi Ishigame, Po-Sung Chu, Tomohisa Sujino, Wataru Suda, Masahira Hattori, Minoru Matsui, Takaharu Okada, Hideyuki Okano, Masayuki Inoue, Toshihiko Yada, Yuko Kitagawa, Akihiko Yoshimura, Mamoru Tanida, Makoto Tsuda, Yusaku Iwasaki, Takanori Kanai

    Nature   585 ( 7826 )   591 - 596   2020.9

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    DOI: 10.1038/s41586-020-2425-3

  • Astrocytic STAT3 activation and chronic itch require IP3R1/TRPC-dependent Ca2+ signals in mice. Reviewed International journal

    Miho Shiratori-Hayashi, Chiharu Yamaguchi, Kazushi Eguchi, Yuto Shiraishi, Keita Kohno, Katsuhiko Mikoshiba, Kazuhide Inoue, Motohiro Nishida, Makoto Tsuda

    The Journal of allergy and clinical immunology   2020.8

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    DOI: 10.1016/j.jaci.2020.06.039

  • Physical disuse contributes to widespread chronic mechanical hyperalgesia, tactile allodynia, and cold allodynia through neurogenic inflammation and spino-parabrachio-amygdaloid pathway activation. Reviewed International journal

    Yusuke Ohmichi, Mika Ohmichi, Ryoichi Tashima, Koji Osuka, Kaori Fukushige, Dominika Kanikowska, Yugo Fukazawa, Hiromu Yawo, Makoto Tsuda, Munekazu Naito, Takashi Nakano

    Pain   161 ( 8 )   1808 - 1823   2020.8

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    DOI: 10.1097/j.pain.0000000000001867

  • Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice. Reviewed International journal

    Kakeru Shimoda, Akiyuki Nishimura, Caroline Sunggip, Tomoya Ito, Kazuhiro Nishiyama, Yuri Kato, Tomohiro Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Motohiro Nishida

    Scientific reports   10 ( 1 )   13926 - 13926   2020.8

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    DOI: 10.1038/s41598-020-70956-5

  • Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6. Reviewed International journal

    Teruaki Ono, Yuta Kohro, Keita Kohno, Hidetoshi Tozaki-Saitoh, Yasuharu Nakashima, Makoto Tsuda

    Brain, behavior, and immunity   2020.7

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    DOI: 10.1016/j.bbi.2020.07.025

  • New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats Reviewed International journal

    Shota Yamamoto, Tomohiro Yamashita, Mayu Ito, Jose M.M. Caaveiro, Nobuaki Egashira, Hidetoshi Tozaki-Saitoh, Makoto Tsuda

    International Journal of Cancer   145 ( 8 )   2107 - 2113   2019.10

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    DOI: 10.1002/ijc.32043

  • Macrophage centripetal migration drives spontaneous healing process after spinal cord injury Reviewed International journal

    Kazu Kobayakawa, Yasuyuki Ohkawa, Shingo Yoshizaki, Tetsuya Tamaru, Takeyuki Saito, Ken Kijima, Kazuya Yokota, Masamitsu Hara, Kensuke Kubota, Yoshihiro Matsumoto, Katsumi Harimaya, Keiko Ozato, Takahiro Masuda, Makoto Tsuda, Tomohiko Tamura, Kazuhide Inoue, V. Reggie Edgerton, Yukihide Iwamoto, Yasuharu Nakashima, Seiji Okada

    Science Advances   5 ( 5 )   2019.5

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    DOI: 10.1126/sciadv.aav5086

  • Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development Reviewed

    Hidetoshi Saitoh, Junya Masuda, Ryu Kawada, Chinami Kojima, Sosuke Yoneda, Takahiro Masuda, Kazuhide Inoue, Tsuda Makoto

    GLIA   67 ( 4 )   729 - 740   2019.4

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    DOI: 10.1002/glia.23570

  • Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure Reviewed

    Tatsuhiro Igawa, Shuhei Kishikawa, Yoshito Abe, Tomohiro Yamashita, Saki Nagai, Mitsunori Shiroishi, Chinatsu Shinozaki, Hiroyuki Tanaka, Hidetoshi Saitoh, Tsuda Makoto, Kazuhide Inoue, Tadashi Ueda

    Purinergic Signalling   2019.3

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    DOI: 10.1007/s11302-019-09646-5

  • Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome Reviewed

    Masaya Yasui, Yuki Menjyo, Kyohei Tokizane, Akiko Shiozawa, Tsuda Makoto, Kazuhide Inoue, Hiroshi Kiyama

    Journal of Neuroinflammation   16 ( 1 )   2019.3

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    DOI: 10.1186/s12974-019-1456-x

  • Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats Reviewed

    Shota Yamamoto, Nobuaki Egashira, Tsuda Makoto, Satohiro Masuda

    Journal of Pharmacological Sciences   138 ( 3 )   214 - 217   2018.11

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    DOI: 10.1016/j.jphs.2018.10.006

  • Interleukin-27 controls basal pain threshold in physiological and pathological conditions Reviewed International journal

    Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka T Interleukin-27 controls basal pain threshold in physiological and pathological conditions.

    Sci Rep   8 ( 1 )   11022   2018.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-29398-3

  • Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex Reviewed

    Tao Chen, Wataru Taniguchi, Qi Yu Chen, Hidetoshi Saitoh, Qian Song, Ren Hao Liu, Kohei Koga, Tsuyoshi Matsuda, Yae Kaito-Sugimura, Jian Wang, Zhi Hua Li, Ya Cheng Lu, Kazuhide Inoue, Tsuda Makoto, Yun Qing Li, Terumasa Nakatsuka, Min Zhuo

    Nature Communications   9 ( 1 )   2018.5

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    DOI: 10.1038/s41467-018-04309-2

  • Temporal Kinetics of Microgliosis in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rodents Reviewed International journal

    Kohno K*, Kitano J*, Kohro Y, Tozaki-Saitoh H, Inoue K, Tsuda M

    Biol Pharm Bull   2018.5

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    DOI: 10.1248/bpb.b18-00278

  • Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin Reviewed

    Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

    Journal of Pharmacological Sciences   2018.1

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    DOI: 10.1016/j.jphs.2018.04.007

  • Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch Reviewed

    Kensho Kanehisa, Miho Shiratori, Keisuke Koga, Hidetoshi Saitoh, Yuta Koro, Kenji Takamori, Tsuda Makoto

    Journal of Dermatological Science   88 ( 2 )   251 - 254   2017.11

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    DOI: 10.1016/j.jdermsci.2017.05.017

  • Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells. Reviewed International journal

    7   11882   2017.9

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    DOI: 10.1038/s41598-017-11506-4

  • Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. Reviewed International journal

    Koga K, Kanehisa K, Kohro Y, Shiratori-Hayashi M, Tozaki-Saitoh H, Inoue K, Furue H, Tsuda M

    Sci Rep   7   4739   2017.7

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    DOI: 10.1038/s41598-017-04972-3

  • P2Y12 receptors in primary microglia activate nuclear factor of activated T cell signaling to induce C-C chemokine 3 expression Reviewed International journal

    Hidetoshi Saitoh et al.

    J Neurochem   141   100 - 110   2017.4

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  • Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction Reviewed International journal

    Nakaya Michio et al.

    J Clin Invest   127   383 - 401   2017.1

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  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed International journal

    Matsunaga Naoya et al.

    EBioMedicine   S2352-3964   30463 - 30467   2016.11

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  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed International journal

    Koyanagi S et al.

    Nat Commun   7   13102   2016.11

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  • Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury Reviewed International journal

    Tomohiro Yamashita et al.

    PLoS One   11   e0165189   2016.10

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  • A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain Reviewed International journal

    Matsumura Y et al.

    Sci Rep   6   32461   2016.8

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  • Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension Reviewed International journal

    Nishimura et al.

    Sci Signal   9   ra7   2016.1

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  • Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia Reviewed International journal

    128 ( 4 )   216 - 220   2015.8

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  • Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. Reviewed International journal

    Igawa T et al.

    FEBS Lett   589   680 - 686   2015.3

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  • Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. Reviewed International journal

    Akagi et al.,

    J Pharmacol Sci   121   172 - 176   2014.11

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  • A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation. Reviewed International journal

    Yasui et al.,

    Glia   62 ( 9 )   1407 - 1417   2014.9

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  • IRF8 is a transcriptional determinant for microglial motility. Reviewed International journal

    Masuda Takahiro et al.

    Purinergic Signal   10 ( 3 )   515 - 521   2014.9

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  • Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia. Reviewed International journal

    Ohi-ishi et al.,

    Mol Pain   10   53   2014.8

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  • Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor Reviewed International journal

    JOURNAL OF BIOCHEMISTRY   153 ( 3 )   275 - 282   2013.3

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    DOI: 10.1093/jb/mvs143

  • GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance Reviewed International journal

    Nakaya Michio, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Motohiro Nishida, Taniguchi H, Sato Y, Matsumoto M, TSUDA MAKOTO, Kuroda M, Kazuhide Inoue, Hitoshi Kurose

    NATURE COMMUNICATIONS   4   1532   2013.2

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    DOI: 10.1038/ncomms2540

  • (R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects Reviewed International journal

    Muratake H, Ito A, Toda T, Suzuki H, Fukasawa H, TSUDA MAKOTO, Kazuhide Inoue, Sugiyama K, Shudo K

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 24 )   7602 - 7604   2012.12

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    DOI: 10.1016/j.bmcl.2012.10.001

  • Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain Reviewed International journal

    Sun L, Wu Z, Yoshinori Hayashi, Peters C, TSUDA MAKOTO, Kazuhide Inoue, Hiroshi Nakanishi

    JOURNAL OF NEUROSCIENCE   32 ( 33 )   11330 - 11342   2012.8

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    DOI: 10.1523/JNEUROSCI.0677-12.2012

  • Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis. Reviewed International journal

    Uesugi A, Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Robaye B, Boeynaems JM, Inoue K.

    Glia   60 ( 7 )   2012.7

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  • CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia. Reviewed International journal

    Toyomitsu E, Tsuda M, Yamashita T, Tozaki-Saitoh H, Tanaka Y, Inoue K.

    Purinergic Signal.   8 ( 2 )   2012.6

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  • Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways. Reviewed International journal

    Kataoka A, Koga Y, Uesugi A, Tozaki-Saitoh H, Tsuda M, Inoue K.

    Purinergic Signal.   7 ( 4 )   2011.12

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  • Astrocytic P2Y1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. Reviewed International journal

    Kuboyama K, Harada H, Tozaki-Saitoh H, Tsuda M, Ushijima K, Inoue K

    J Cereb Blood Flow Metab   31 ( 9 )   2011.9

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    DOI: 10.1038/jcbfm.2011.49.

  • Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Reviewed International journal

    Maeda M, Tsuda M, Tozaki-Saitoh H, Inoue K, Kiyama H

    Glia   58 ( 15 )   2010.11

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  • Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. Reviewed International journal

    Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S

    Mol Pain   6   2010.11

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  • P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. Reviewed International journal

    Shiratori M, Tozaki-Saitoh H, Yoshitake M, Tsuda M, Inoue K

    J Neurochem   114 ( 3 )   2010.8

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  • Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. Reviewed International journal

    Hasegawa S, Kohro Y, Shiratori M, Ishii S, Shimizu T, Tsuda M, Inoue K

    PLoS ONE 5: e10467 (2010)   2010.5

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  • Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury Reviewed International journal

    Hasegawa S, Kohro Y, Tsuda M, Inoue K

    Mol Pain   5   2009.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia Reviewed International journal

    Masuda J, Tsuda M, Tozaki-Saitoh H, Inoue K

    Mol Pain   5   2009.5

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  • Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief Reviewed International journal

    Nagata K, Imai T, Yamashita T, Tsuda M, Tozaki-Saitoh H, Inoue K.

    Mol Pain   5   2009.4

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  • Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. Reviewed International journal

    Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K

    J Neurochem 108(1): 115-125 (2009)   2009.1

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  • Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor Reviewed International journal

    Tsuda M, Ishii S, Masuda T, Hasegawa S, Nakamura K, Nagata K, Yamashita T, Furue H, Tozaki-Saito H, Yoshimura M, Koizumi S, Shimizu T and Inoue K

    2007.9

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  • Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn. Reviewed International journal

    Ikeda H, Tsuda M, Inoue K, Murase K.

    Eur J Neurosci. 2007 Mar;25(5):1297-306.   2007.3

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  • Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells. Reviewed International journal

    Tozaki-Saitoh H, Koizumi S, Sato Y, Tsuda M, Nagao T, Inoue K.

    Mol Pharmacol. 2006 Jul;70(1):319-28.   2006.7

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  • Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors. Reviewed International journal

    Shiokawa H, Nakatsuka T, Furue H, Tsuda M, Katafuchi T, Inoue K, Yoshimura M.

    J Physiol. 2006 Jun 15;573(Pt 3):753-63.   2006.6

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  • Long-lasting change in brain dynamics induced by methamphetamine: enhancement of protein kinase C-dependent astrocytic response and behavioral sensitization. Reviewed International journal

    Narita M, Miyatake M, Shibasaki M, Tsuda M, Koizumi S, Narita M, Yajima Y, Inoue K, Suzuki T.

    J Neurochem. 2005 Jun;93(6):1383-92.   2005.6

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  • Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Reviewed International journal

    Koizumi S, Fujishita K, Inoue K, Shigemoto-Mogami Y, Tsuda M, Inoue K.

    Biochem J. 2004 Jun 1;380(Pt 2):329-38.   380   329 - 338   2004.6

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    DOI: 10.1042/BJ20031089

  • Signaling of ATP receptors in glia-neuron interaction and pain. Reviewed International journal

    Inoue K, Koizumi S, Tsuda M, Shigemoto-Mogami Y.

    Life Sci. 2003 Dec 5;74(2-3):189-97.   74 ( 2-3 )   189 - 197   2003.12

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    DOI: 10.1016/j.lfs.2003.09.006

  • Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Reviewed International journal

    Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K.

    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11023-8.   100 ( 19 )   11023 - 11028   2003.9

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    DOI: 10.1073/pnas.1834448100

  • Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain. Reviewed International journal

    Tsuda M, Shigemoto-Mogami Y, Ueno S, Koizumi S, Ueda H, Iwanaga T, Inoue K.

    Eur J Neurosci. 2002 May;15(9):1444-50.   15 ( 9 )   1444 - 1450   2002.5

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    DOI: 10.1046/j.1460-9568.2002.01982.x

  • Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. Reviewed International journal

    Shigemoto-Mogami Y, Koizumi S, Tsuda M, Ohsawa K, Kohsaka S, Inoue K.

    J Neurochem. 2001 Sep;78(6):1339-49.   78 ( 6 )   1339 - 1349   2001.9

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    DOI: 10.1046/j.1471-4159.2001.00514.x

  • Role of endogenous ATP at the incision area in a rat model of postoperative pain. Reviewed International journal

    Tsuda M, Koizumi S, Inoue K.

    Neuroreport. 2001 Jun 13;12(8):1701-4.   12 ( 8 )   1701 - 1704   2001.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00001756-200106130-00036

  • Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord. Reviewed International journal

    Yajima Y, Narita M, Tsuda M, Imai S, Kamei J, Nagase H, Suzuki T.

    Life Sci. 2000 Dec 29;68(6):719-25.   2000.12

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  • Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. Reviewed International journal

    Suzuki T, Kato H, Aoki T, Tsuda M, Narita M, Misawa M.

    Life Sci. 2000 Jun 16;67(4):383-9.   2000.6

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  • Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. Reviewed International journal

    Tsuda M, Ueno S, Inoue K.

    Br J Pharmacol. 1999 Dec;128(7):1497-504.   1999.12

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  • In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system. Reviewed International journal

    Tsuda M, Ueno S, Inoue K.

    Br J Pharmacol. 1999 May;127(2):449-56.   1999.5

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  • Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. Reviewed International journal

    Suzuki T, Shimizu N, Tsuda M, Soma M, Misawa M.

    Eur J Pharmacol. 1999 Mar 19;369(2):163-8.   1999.3

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  • Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice. Reviewed International journal

    Suzuki T, Kato H, Tsuda M, Suzuki H, Misawa M.

    Life Sci. 1999;64(12):PL151-6.   1999.2

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  • Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons. Reviewed International journal

    Ueno S, Tsuda M, Iwanaga T, Inoue K.

    Br J Pharmacol. 1999 Jan;126(2):429-36.   1999.1

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  • NMDA receptor antagonists potently suppress the spontaneous withdrawal signs induced by discontinuation of long-term diazepam treatment in Fischer 344 rats. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Brain Res. 1998 Apr 20;790(1-2):82-90.   1998.4

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  • Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. Reviewed International journal

    Tsuda M, Shimizu N, Yajima Y, Suzuki T, Misawa M.

    Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):309-15.   1998.3

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  • Subsensitivity to mitochondrial diazepam binding inhibitor receptor agonist FGIN-1-27-induced antiseizure effect in diazepam-withdrawn mice. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Life Sci. 1998;62(14):PL213-7.   1998.2

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  • Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice. Reviewed International journal

    Tsuda M, Shimizu N, Yajima Y, Suzuki T, Misawa M.

    Eur J Pharmacol. 1998 Feb 26;344(1):27-30.   1998.2

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  • Region-specific changes in [3H]dizocilpine binding in diazepam-withdrawn rats. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Neurosci Lett. 1998 Jan 9;240(2):113-5.   1998.1

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  • Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal. Reviewed International journal

    Tsuda M, Chiba Y, Suzuki T, Misawa M.

    Eur J Pharmacol. 1998 Jan 12;341(2-3):R1-2.   1998.1

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  • Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Brain Res Dev Brain Res. 1997 Dec 19;104(1-2):201-4.   1997.12

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  • Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Life Sci. 1997;60(23):PL339-43.   1997.5

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  • Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice. Reviewed International journal

    Kamei J, Sodeyama M, Tsuda M, Suzuki T, Nagase H.

    Life Sci. 1997;60(22):PL 333-7.   1997.4

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  • Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Eur J Pharmacol. 1997 Apr 11;324(1):63-6.   1997.4

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  • Role of the NMDA receptor complex in DMCM-induced seizure in mice. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M.

    Neuroreport. 1997 Feb 10;8(3):603-6.   1997.2

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  • Mecamylamine-precipitated nicotine-withdrawal aversion in rats. Reviewed International journal

    Suzuki T, Ise Y, Tsuda M, Maeda J, Misawa M.

    Eur J Pharmacol. 1996 Oct 31;314(3):281-4.   1996.10

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  • Involvement of the opioid system in the anxiolytic effect of diazepam in mice. Reviewed International journal

    Tsuda M, Suzuki T, Misawa M, Nagase H.

    Eur J Pharmacol. 1996 Jun 20;307(1):7-14.   1996.6

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  • Diazepam pretreatment suppresses morphine withdrawal signs in the mouse. Reviewed International journal

    Suzuki T, Tsuda M, Narita M, Funada M, Mizoguchi H, Misawa M.

    Life Sci. 1996;58(4):349-57.   1995.12

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  • Blockade of morphine-induced place preference by diazepam in mice. Reviewed International journal

    Suzuki T, Tsuda M, Funada M, Misawa M.

    Eur J Pharmacol. 1995 Jul 14;280(3):327-30.   1995.7

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  • Potentiation of physical dependence on diazepam by ondansetron in rats. Reviewed International journal

    Mizoguchi H, Shirayama N, Tsuda M, Yoshiike M, Suzuki T, Misawa M.

    Life Sci. 1994;54(9):PL131-6.   1994.7

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Books

  • 実践行動薬理学:脊髄ミクログリアのATP受容体を介する新しい神経障害性疼痛メカニズム

    津田誠,井上和秀( Role: Edit)

    株式会社金芳堂  2010.3 

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    Language:Japanese   Book type:Scholarly book

  • On the role of ATP-gated P2X receptors in acute, inflammatory and neuropathic pain

    Toulme E, Tsuda M, Khakh BS, Inoue K( Role: Edit)

    CRC Press  2009.11 

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    Language:English   Book type:Scholarly book

  • The nociceptive membrane, Current Topics in Membrane 57, Chapter 9. P2X receptors in sensory neurons.

    M. Tsuda, K. Inoue( Role: Edit)

    Elsevier, pp277-310, (2006)  2006.9 

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    Language:English   Book type:Scholarly book

  • 脊髄反射と脊髄/中枢性感作

    津田誠( Role: Joint author)

    「疼痛医学」教科書制作研究会  2020.3 

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    Language:Japanese   Book type:Scholarly book

  • Microglia in the CNS and neuropathic pain

    Tsuda Makoto

    Springer New York LLC  2018.1 

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    Responsible for pages:77-91   Language:English  

    DOI: 10.1007/978-981-13-1756-9_7

  • 神経障害性疼痛のメカニズム解析とそれによる創薬について

    津田誠( Role: Joint author)

    一般社団法人 医薬品医療機器レギュラトリーサイエンス財団  2017.11 

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    Language:Japanese   Book type:Scholarly book

  • 神経障害性疼痛における最新メカニズムと創薬への応用

    津田誠( Role: Joint author)

    技術情報協会  2017.8 

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    Language:Japanese   Book type:Scholarly book

  • グリアと神経障害性痛(痛みのScience&Practice)

    津田 誠( Role: Joint author)

    文光堂  2014.5 

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    Language:Japanese   Book type:Scholarly book

  • Intrathecal infusion of microglia cells.

    Masuda Takahiro et al.( Role: Joint author)

    Springer  2013.9 

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    Language:English   Book type:Scholarly book

  • Lentiviral transduction of cultured microglia.

    Masuda Takahiro et al.( Role: Joint author)

    Springer  2013.9 

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    Language:English   Book type:Scholarly book

  • 神経障害性疼痛

    井上 和秀, 津田 誠( Role: Joint author)

    克誠堂出版  2012.10 

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    Responsible for pages:pp24-32「脊髄・二次ニューロンの可塑的変化と神経障害性疼痛」   Language:Japanese   Book type:Scholarly book

  • 慢性疼痛における薬剤選定と治療薬開発

    津田誠,井上和秀( Role: Joint author)

    技術情報協会  2010.6 

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    Language:Japanese   Book type:Scholarly book

  • Chronic pain and microglia: the role of ATP.

    Inoue K, Tsuda M, Koizumi S.( Role: Joint author)

    Novartis Found Symp. 261, 55-64; discussion 64-67, 149-54 (2004).  2004.5 

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    Language:English   Book type:Scholarly book

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Presentations

  • A new mechanism for pain chronicity revealed by microglia Invited International conference

    Makoto Tsuda

    Cold Spring Harbor Asia-GLIA  2023.4 

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    Event date: 2024.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脊髄後角での痒み選択的神経回路における新たな構成要素 Invited

    津田誠

    第96回日本生化学会大会  2023.10 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 痒み感覚の神経伝達機構と皮膚炎による変化 Invited

    津田誠

    第49回日本神経内分泌学会  2023.10 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Control of neuropathic pain development and recovery by spinal glial cells Invited

    2023.8 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 痛みの慢性化と緩和に関わるグリア細胞 Invited

    津田誠

    日本ペインクリニック学会第57回学術集会  2023.7 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 痛みの慢性化と中枢神経系マクロファージ Invited

    津田誠

    第23回日本抗加齢医学会総会  2023.6 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Mechanism for chronic pain revealed by glial cells Invited International conference

    Makoto Tsuda

    39th International Annual Meeting in Pharmaceutical Sciences  2024.3 

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    Event date: 2024.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Thailand  

  • New mechanism for pain chronicity revealed by microglial subset Invited

    Makoto Tsuda

    THE 50th NAITO CONFERENCE  2023.10 

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    Event date: 2024.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • A new mechanism for pain chronicity revealed by microglia subset Invited International conference

    Makoto Tsuda

    JSICR/MMCB 2023 Joint Symposium  2023.5 

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    Event date: 2024.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • グリア細胞の多様性と慢性疼痛 Invited

    津田誠

    日本薬学会第144年会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脊髄における痒み情報伝達と慢性皮膚炎による変調 Invited

    津田誠

    第101回日本生理学会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:北九州   Country:Japan  

  • ミクログリアサブセットから明らかになった新しい慢性疼痛メカニズム Invited

    津田誠

    第129回日本解剖学会総会・全国学術集会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:沖縄   Country:Japan  

  • 神経障害性の痛みにおける新しい慢性化メカニズム Invited

    津田誠

    日本薬学会第143年会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • グリア研究から難治性慢性疼痛の理解を目指す Invited International conference

    津田誠

    第62回日本定位・機能神経外科学会  2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:山口   Country:Japan  

  • ミクログリアから痛みの慢性化メカニズムを探る Invited

    津田誠

    第13回免疫適塾  2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(オンライン)   Country:Japan  

  • 慢性疼痛からの自然回復過程におけるグリア細胞の役割 Invited

    津田誠

    第96回日本薬理学会年会  2022.11 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • グリア細胞から慢性疼痛のメカニズムを紐解く Invited

    津田誠

    第26回日本心療内科学会総会・学術大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • ニューロン-グリア相互作用から考える慢性疼痛のメカニズム Invited

    津田誠

    第54回関東機能的脳外科カンファレンス  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(オンライン)   Country:Japan  

  • 痛みの慢性化に関わる脊髄後角細胞 Invited

    津田誠

    第28回日本遺伝子細胞治療学会学術集会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 神経障害性疼痛機序から考えられる新たな治療法の可能性を探る Invited

    津田誠

    第56回日本ペインクリニック学会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 慢性疼痛の緩解と再発に関わるミクログリアサブセット Invited

    津田誠

    Science Café  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(オンライン)   Country:Japan  

  • 慢性疼痛とグリア細胞 ~新たな方向性~ Invited

    津田誠

    日本麻酔科学会第69回学術集会  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 痛覚伝達変調におけるグリア細胞の役割 Invited

    津田誠

    第63回日本神経学会学術大会  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 痒みの神経回路と慢性化 Invited

    津田誠

    第8回総合アレルギー講習会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜*ハイブリッド   Country:Japan  

  • 皮膚炎に伴う脊髄後角でのかゆみ感作メカニズム

    津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • ミクログリアサブセットによる新しい疼痛制御 Invited

    津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • 神経-グリア相互連関からわかってきた神経障害性疼痛メカニズム Invited

    津田誠

    第19回日本臨床腫瘍学会学術集会  2022.2 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都*ハイブリッド   Country:Japan  

  • 痛みの慢性化メカニズム:グリア細胞と末梢シグナルから考える Invited

    津田誠

    千里ライフサイエンスセミナーS5  2022.1 

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    Event date: 2022.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪*オンライン   Country:Japan  

  • グリア細胞から紐解く慢性疼痛メカニズム Invited

    津田誠

    日本薬学会北陸支部特別講演会  2022.1 

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    Event date: 2022.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢*オンライン   Country:Japan  

  • 脊髄におけるかゆみ情報伝達と調節 Invited

    津田誠

    環境医学研究所・順天堂かゆみ研究センター第7回学術シンポジウム  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 慢性掻痒における一次求心性神経由来NPTX2の役割

    津田誠,兼久賢章,前嶋翔,坂本浩隆,Paul Worley

    第43回日本疼痛学会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知*オンライン   Country:Japan  

  • ミクログリアと慢性疼痛:新しい調節機構 Invited

    津田誠

    第43回日本疼痛学会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:愛知*オンライン   Country:Japan  

  • 神経-グリア相互作用による痒みの慢性化機構 Invited

    津田誠

    第30回国際痒みシンポジウム  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京*オンライン   Country:Japan  

  • 慢性疼痛におけるミクログリアの新しい役割

    津田誠

    第94回日本生化学会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜*オンライン   Country:Japan  

  • 脊髄後角アストロサイトを介する新しい痛覚調節メカニズム Invited

    津田誠

    第三回形態解析ワークショップ  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京*オンライン   Country:Japan  

  • 皮膚からの痛覚神経伝達 Invited

    津田誠

    第29回日本発汗学会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島*オンライン   Country:Japan  

  • アストロサイトサブセットによる新しい疼痛制御機構 Invited

    津田誠

    生体機能と創薬シンポジウム2020-2021  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌*ハイブリッド   Country:Japan  

  • グリア細胞がつくる新しい痛覚感作機構 Invited

    津田誠

    第14回日本緩和医療薬学会年会  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山*オンライン   Country:Japan  

  • Role of spinal glial cells in the chronicity of pain Invited

    2021.3 

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    Event date: 2021.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 神経障害性疼痛とミクログリア ~過去,現在,そして今後~ Invited

    津田誠

    第42回日本疼痛学会  2020.12 

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    Event date: 2020.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 慢性疼痛につながる脊髄内ネットワークの変化 Invited

    津田誠

    第13回日本運動器疼痛学会  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • ノルアドレナリンによる疼痛制御機構:グリア細胞を介する新しいメカニズム Invited

    津田誠

    第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会(NPBPPP2020合同年会)  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • 脊髄後角ミクログリアサブセットと神経障害性疼痛 Invited

    津田誠

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 痛覚情報伝達とその修飾機構 Invited

    津田誠

    千里ライフサイエンスセミナーN  2019.11 

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    Event date: 2019.11 - 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • ミクログリアサブセットと慢性疼痛 Invited

    津田誠

    第35回Wakoワークショップ  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ミクログリアによる痛みの慢性化メカニズム Invited

    津田誠,齊藤秀俊

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Modulation of mechanosensory behavior by a spinal astrocyte population Invited International conference

    Makoto Tsuda

    2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Pivotal role of spinal astrocytes in the chronicity of itch Invited International conference

    Makoto Tsuda

    International Brain Research Organization (IBRO) World Congress  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 神経障害性疼痛の脊髄内メカニズム Invited

    津田誠

    日本麻酔科学会九州麻酔科学会第57回大会  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • Modulation of somatosensory information processing by the CNS immune cells microglia Invited

    Makoto Tsuda

    2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 神経障害性疼痛の克服に向けた基礎研究からの挑戦 Invited

    津田誠

    日本ペインクリニック学会53回大会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • 中枢神経系炎症性ミクログリアと慢性疼痛 Invited

    津田誠

    第40回日本・炎症再生医学会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • 脳から脊髄への新しい下行性感覚制御メカニズム Invited

    津田誠

    第41回日本疼痛学会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • New approach for investigating neuropathic allodynia by optogenetics in rats Invited International conference

    Makoto Tsuda

    The 7th International Congress on Neuropathic Pain (NeuPSIG 2019)  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:United Kingdom  

  • 痒みの慢性化メカニズムをグリア細胞から探る Invited

    津田誠

    日本薬学会第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 脊髄後角アストロサイトサブポピュレーションによる体性感覚制御

    津田誠

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 慢性的な痒みと脊髄グリア細胞 Invited

    津田誠

    生体機能と創薬シンポジウム2018  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Modulation of pain processing by spinal cord glia International conference

    Makoto Tsuda

    2018 Toronto Symposium on Synaptic Plasticity in Health and Diseases  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 感覚情報処理における脊髄グリア細胞の役割 Invited

    津田誠

    第31回日本顎関節学会・第23回日本口腔顔面痛学会・第33回日本歯科心身医学会 合同大会  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:北九州   Country:Japan  

  • Seeking the mechanisms of chronic itch by scratching: sensory neurons, circuits, and glia Invited International conference

    Makoto Tsuda

    2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脊髄後角のニューロン・グリア相互作用が作り出す慢性掻痒

    津田誠

    第40回日本疼痛学会  2018.6 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • 慢性掻痒の神経系メカニズム Invited

    津田誠

    第117回日本皮膚科学会総会  2018.6 

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    Event date: 2018.5 - 2018.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:広島   Country:Japan  

  • 痒みの神経伝達機構 Invited

    津田誠

    第117回日本皮膚科学会総会  2018.6 

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    Event date: 2018.5 - 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島   Country:Japan  

  • 脊髄後角における体性感覚情報処理とグリア細胞 Invited

    津田誠

    第一回三融会主催武田神経科学シンポジウム  2018.3 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Microglial modulation of neuropathic pain Invited International conference

    Makoto Tsuda

    Translational Pain Research Symposium  2017.6 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  • グリア細胞から紐解く神経障害性疼痛メカニズム Invited

    津田 誠

    第39回日本疼痛学会  2017.6 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • かゆみの慢性化における脊髄後角アストロサイトの関与 Invited

    津田誠

    順天堂大学環境医学研究所 特別学術シンポジウム  2017.6 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • Purinergic stimulation of spinal microglia contributes to chronic pain Invited International conference

    Makoto Tsuda

    XIII European Meeting on Glial Cells in Health and Disease  2017.7 

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    Event date: 2018.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United Kingdom  

  • 脊髄後角アストロサイトによる体性感覚情報プロセシング変化

    津田 誠,高露雄太,井上和秀

    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会  2017.9 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • Glial cells: key elements for the pathogenesis of neuropathic pain Invited International conference

    Makoto Tsuda

    Asia Dry Eye Summit 2017  2017.10 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • Modulation of mechanical sensitivity by spinal glial cells Invited International conference

    Makoto Tsuda

    7th Asian pain symposium  2017.10 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • 慢性疼痛発症のメカニズムから考える神経障害性疼痛の治療標的 Invited

    津田誠

    第352回福岡臨床整形外科医会研修会  2017.11 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 基礎から痛みを学ぶ Invited

    津田誠

    角膜カンファランス2018  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島   Country:Japan  

  • アトピー性皮膚炎等の慢性掻痒に対する中枢神経系を標的にした創薬戦略 Invited

    津田 誠

    日本薬学会第137年会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 神経障害性アロディニア研究における光遺伝学を用いた新たな道 Invited

    津田 誠

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • 慢性のかゆみの原因を解き明かす Invited

    津田 誠

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:長崎   Country:Japan  

  • P2Xチャネルを介したミクログリアの活性化と慢性疼痛 Invited

    津田 誠

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • Glial cells in the spinal cord and chronic pain Invited International conference

    TSUDA MAKOTO

    19th Takeda Science Foundation Symposium on Bioscience  2017.1 

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    Event date: 2017.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Glial cells in the spinal dorsal horn: key players for chronic pain and itch Invited

    2016.12 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • Microglial purinergic signaling and neuropathic pain Invited International conference

    TSUDA MAKOTO

    46th Annual Meeting Society for Neuroscience  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Spinal microglia activated by purinergic receptors and neuropathic pain Invited International conference

    TSUDA MAKOTO

    PSK-PSJ joint-symposium in 2016  2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Crucial role of spinal dorsal horn astrocytes in itch chronicity Invited

    2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 痛みと痒みの慢性化とグリア細胞 Invited

    津田 誠

    第36回鎮痛薬オピオイドペプチドシンポジウム  2016.8 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • 痛みの慢性化に重要なグリア細胞 Invited

    津田 誠

    第46回日本神経精神薬理学会年会  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Seoul   Country:Korea, Republic of  

  • Spinal Microglia Activated by Purinergic Signaling and Neuropathic Pain Invited International conference

    TSUDA MAKOTO

    Keystone Symposia on Microglia in the Brain  2016.6 

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    Event date: 2016.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 痒みの慢性化と脊髄後角アストロサイト Invited

    津田 誠

    第115回日本皮膚科学会総会  2016.5 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 脊髄後角アストロサイトによる感覚情報伝達変調 Invited

    津田 誠

    第24回日本腰痛学会  2016.4 

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    Event date: 2016.4 - 2017.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:山梨   Country:Japan  

  • 神経障害性疼痛におけるP2X4受容体陽性ミクログリアの役割 Invited

    津田 誠ら

    日本薬学会第136年会  2016.3 

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    Event date: 2016.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 神経障害性疼痛の解明を目指した光遺伝学アプローチ Invited

    津田 誠

    第89回日本薬理学会年会  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • A crucial role of spinal astrocytes in chronic itch Invited

    2016.3 

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    Event date: 2016.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Microglial purinergic signaling in the spinal cord and neuropathic pain Invited International conference

    6th Asian Pain Symposium  2015.11 

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    Event date: 2015.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • 難治性疼痛におけるグリア細胞ATP受容体の関与 Invited

    津田 誠

    第9回日本緩和医療薬学会年会  2015.10 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Dorsal horn astrocytes: new player in chronic itch Invited International conference

    8th World Congress on Itch (WCI 2015)  2015.9 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 体性感覚系疾患におけるグリア細胞の役割 Invited

    津田 誠

    第45回日本神経精神薬理学会  2015.9 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Microglial transcription factors and neuropathic pain Invited

    2015.9 

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    Event date: 2015.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Spinal glial cells and chronic pain Invited International conference

    2015 Cold Spring Harbor Asia Conference  2015.6 

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    Event date: 2015.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:China  

  • Microglia as a pain maker in neuropathic pain: Rodent studies Invited International conference

    13th World Congress of Biological Psychiatry  2015.6 

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    Event date: 2015.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Greece  

  • 脊髄グリア細胞からの研究アプローチ Invited

    津田 誠ら

    第29回日本整形外科学会基礎学術集会  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島   Country:Japan  

  • Microglial purinoceptors and chronic pain Invited International conference

    TSUDA MAKOTO et al.

    Purines2014  2014.7 

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    Event date: 2014.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Germany  

  • Non-cell-autonomous modulation of neuropathic pain by microglia Invited International conference

    TSUDA MAKOTO et al.

    17th World Congress of Basic and Clinical Pharmacology  2014.7 

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    Event date: 2014.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:South Africa  

  • グリア細胞から見た神経障害性疼痛メカニズム Invited

    津田 誠

    第55回日本神経学会学術大会  2014.5 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 神経障害性疼痛-ミクログリアを中心とした病態メカニズム- Invited

    津田 誠

    第43回日本脊椎脊髄病学会学術集会  2014.4 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • ミクログリアでのP2X4受容体発現と神経障害性疼痛におけるIRF転写因子ネットワークの役割

    津田 誠, 増田 隆博, 吉永遼平, 岩本祥佑, 田村智彦, 井上 和秀

    日本薬学会第133回年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • アストロサイト特異的STAT3欠損マウスでは神経損傷後のアストロサイトの活性化と神経障害性疼痛が抑制される

    高露雄太, 津田 誠, 坂口瑛美, 齊藤 秀俊, 岡野栄之, 井上 和秀

    日本薬学会第133回年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 転写因子MafBはミクログリアの活性化過程を調節し神経障害性疼痛に関 与する

    齊藤 秀俊, 津田 誠, 井上 和秀

    日本薬学会第133回年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 転写因子IRF8欠損によるATP誘発ミクログリアケモタキシスの抑制

    西本奈央, 増田 隆博, 冨山大輔, 吉永遼平, 田村智彦, 齊藤 秀俊, 津田 誠, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • アストロサイト特異的STAT3欠損は神経損傷後のアストロサイト活性化および神経障害性疼痛を抑制する

    高露雄太, 津田 誠, 坂口瑛美, 齊藤 秀俊, 岡野栄之, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • CCL21による脊髄ミクログリアのMafB発現誘導

    小嶋ちなみ, 齊藤 秀俊, 津田 誠, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 転写因子MafBは末梢神経損傷後の神経障害性疼痛発症に寄与する

    川田竜, 齊藤 秀俊, 増田 隆博, 津田 誠, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 線維筋痛症モデルマウスで発症するアロディニアにおけるIRF8の役割

    赤木貴紀, 津田 誠, 増田 隆博, 齊藤 秀俊, 田村智彦, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • IRF8-IRF5軸は神経障害性疼痛発現を担うP2X4受容体高発現ミクログリアを誘導する

    増田 隆博, 津田 誠, 吉永遼平, 岩本祥佑, 西山晃, 西本奈央, 齊藤 秀俊, 田村智彦, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • IRF8 is a critical transcription factor required for transforming microglia into a reactive phenotype after nerve injury International conference

    Masuda Takahiro, TSUDA MAKOTO, Ryohei Yoshinaga, Hidetoshi Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inoue

    42th Annual Meeting Society for Neuroscience  2012.10 

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    Event date: 2012.10

    Language:English  

    Country:United States  

  • Spinal cord microglia in neuropathic pain signaling Invited International conference

    TSUDA MAKOTO, Masuda Takahiro, Kazuhide Inoue

    11th Biennial Meeting of Asian Pacific Society for Neurochemistry and 55th Meeting of Japanese Society for Neurochemistry  2012.10 

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    Event date: 2012.9 - 2012.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • IRF5 is required for IRF8-derived microglial activation and contributes to neuropathic pain International conference

    Masuda Takahiro, TSUDA MAKOTO, Ryohei Yoshinaga, Tomohiko Tamura, Kazuhide Inoue

    2012.9 

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    Event date: 2012.9 - 2012.10

    Language:English  

    Country:Japan  

  • 活性化ミクログリアの転写制御と神経障害性疼痛 Invited

    津田 誠, 井上 和秀

    第35回日本神経科学大会Neuro2012  2012.9 

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    Event date: 2012.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • Neuropathic pain:新たな病態解明と画期的新薬の開発をめざして Invited

    津田 誠, 井上 和秀

    第23回日本末梢神経学会学術集会  2012.9 

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    Event date: 2012.8 - 2012.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • IRFファミリー転写因子群によるミクログリア遺伝子の発現制御と神経障害性疼痛

    増田 隆博, 津田 誠, 田村智彦, 井上 和秀

    第34回日本疼痛学会  2012.7 

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    Event date: 2012.7

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • IRF8 is a critical transcription for transforming microglia into a reactive phenotype International conference

    TSUDA MAKOTO, Masuda Takahiro, Ryohei Yoshinaga, Hidetoshi Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inoue

    The 7th International Conference of Neurons and Brain Diseases  2012.6 

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    Event date: 2012.6

    Language:English  

    Country:Canada  

  • IRF Family Transcription Factor Axis Governs Gene Expression Program in Microglia Gating Neuropathic Pain International conference

    Masuda Takahiro, TSUDA MAKOTO, Ryohei Yoshinaga, Nao Nishimoto, Shosuke Iwamoto, Hidetoshi Saitoh, Tomohiko Tamura, Kazuhide Inoue

    Purine 2012  2012.6 

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    Event date: 2012.5 - 2012.6

    Language:English  

    Country:Japan  

  • CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia Invited International conference

    Purine 2012  2012.5 

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    Event date: 2012.5 - 2012.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Transcriptional regulation of P2X4R and neuropathic pain Invited International conference

    TSUDA MAKOTO, Masuda Takahiro, Hidetoshi Saitoh, Kazuhide Inoue

    Purine 2012  2012.5 

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    Event date: 2012.5 - 2012.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 難治性慢性疼痛におけるミクログリアの重要性 Invited

    津田誠,井上和秀

    第117回日本解剖学会総会・全国学術集会  2012.3 

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    Event date: 2012.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:山梨県甲府   Country:Japan  

  • 神経障害性疼痛時におけるIRFファミリー転写因子を基軸としたミクログリア遺伝子の発現制御

    増田隆博,津田誠,吉永遼平,西本奈央,岩本祥祐,田村智彦,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Venue:京都市   Country:Japan  

  • グリア細胞の役割から慢性疼痛メカニズムを探る Invited

    津田誠,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • 脊髄ミクログリアのinterferon regulatory factor-5は神経障害性疼痛の発現に重要な転写因子である

    吉永遼平,津田誠,増田隆博,西本奈央,齊藤秀俊,田村智彦,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Venue:京都市   Country:Japan  

  • IRF8 is a critical transcription factor required for microglia activation Invited

    Makoto Tsuda, Takahiro Masuda, Kazuhide Inoue

    2011.12 

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    Event date: 2011.12

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 神経障害性疼痛の維持におけるJAK-STAT3 シグナリングの役割

    津田誠,高露雄太,辻川智子,矢野貴之,北野順子,齊藤秀俊,井上和秀

    第39回薬物活性シンポジウム  2011.11 

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    Event date: 2011.11

    Venue:福岡県福岡市   Country:Japan  

  • 神経障害性疼痛に重要なミクログリア転写因子 Invited

    津田誠,増田隆博,齊藤秀俊,井上和秀

    第39回薬物活性シンポジウム  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡県福岡市   Country:Japan  

  • 神経障害性疼痛とグリア細胞~その役割と分子メカニズム~ Invited

    津田誠,井上和秀

    第4回日本運動器疼痛学会  2011.11 

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    Event date: 2011.11

    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • Interferon regulatory factor-8は、神経損傷後に見られる脊髄ミクログリアの過活動状態への移行に重要な転写因子である

    増田隆博,津田誠,吉永遼平,齊藤秀俊,田村智彦,井上和秀

    第54回日本神経化学会大会  2011.9 

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    Event date: 2011.9

    Venue:石川県山代温泉   Country:Japan  

  • 脊髄ミクログリアのinterferon regulatory factor-5は神経障害性疼痛の発現に重要な転写因子である

    吉永遼平,津田誠,増田隆博,西本奈央,齋藤秀俊,田村智彦,井上和秀

    第54回日本神経化学会大会  2011.9 

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    Event date: 2011.9

    Venue:石川県山代温泉   Country:Japan  

  • IRF8 transcription factor directs microglia to be a hyperactive phenotype International conference

    Masuda, T.; Tsuda, M.; Yoshinaga, R.; Tozaki-Saitoh, H.; Tamura, T.; Inoue, K.

    10th Euroglia Meeting on Glial Cells in Health and Diseases  2011.9 

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    Event date: 2011.9

    Country:Czech Republic  

  • Microglia in pain signaling Invited International conference

    Makoto Tsuda, Takahiro Masuda, Kazuhide Inoue

    10th Euroglia Meeting on Glial Cells in Health and Diseases  2011.9 

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    Event date: 2011.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脊髄グリア細胞から探る神経障害性疼痛メカニズム Invited

    津田誠,井上和秀

    第16回日本緩和医療学会学術大会  2011.7 

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    Event date: 2011.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:札幌   Country:Japan  

  • Spinal microglia: crucial non-neuronal cells for neuropathic pain Invited International conference

    Makoto Tsuda

    2nd KPRC Seoul Pain Symposium Program  2011.6 

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    Event date: 2011.6

    Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 痛みの慢性化を抑制するグリア細胞制御 Invited

    津田誠,井上和秀

    日本麻酔科学会第58回学術集会  2011.5 

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    Event date: 2011.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • ミクログリアでのP2X4受容体発現を増加させ神経障害性疼痛の形成に関与する損傷ニューロン由来因子CCL21

    津田誠,Knut Biber,齊藤秀俊,塚本恵子,豊満笑加,増田隆博,Hendrikus Boddeke,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • JAK-STAT3シグナリングは神経障害性疼痛の維持に重要な脊髄アストロサイトの増殖を調節する

    津田誠,高露雄太,辻川智子,矢野貴之,北野順子,齊藤秀俊,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • 脊髄ミクログリア細胞-神経因性疼痛の新しい治療薬開発ターゲットになり得るか? Invited

    津田誠,井上和秀

    第25回日本整形外科学会基礎学術集会  2010.10 

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    Event date: 2010.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • ATP受容体とミクログリア細胞を標的にした新しい鎮痛薬の可能性 Invited

    津田誠,井上和秀

    第4回日本緩和医療薬学会年会  2010.9 

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    Event date: 2010.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島   Country:Japan  

  • 脊髄ミクログリア:難治性慢性疼痛における重要な役者 Invited

    津田誠,増田隆博,齊藤秀俊,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • ATP受容体から難治性慢性疼痛メカニズムを探る Invited

    津田誠,井上和秀

    日本薬学会第130年会  2010.3 

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    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • 痛みの慢性化メカニズムにおけるP2Xイオンチャネルの役割 Invited

    津田誠,井上和秀

    日本薬学会第130年会  2010.3 

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    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • グリア細胞を標的にした新しい鎮痛薬の可能性 Invited

    津田誠,井上和秀

    日本薬学会第130年会  2010.3 

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    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:岡山   Country:Japan  

  • (Medical/Neuroscience) Glia & Diseases: Spinal microglia are key players for understanding mechanisms of intractable chronic pain Invited International conference

    Makoto Tsuda

    4th Symposium of Japanese-French Frontiers of Science (JFFoS)  2010.1 

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    Event date: 2010.1

    Presentation type:Oral presentation (general)  

    Country:France  

  • Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays International conference

    Makoto Tsuda, Kazuya Kuboyama, Tomoyuki Inoue, Kenichiro Nagata, Hidetoshi Tozaki-Saitoh and Kazuhide Inoue

    39th Annual Meeting Society for Neuroscience  2009.10 

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    Event date: 2009.10

    Country:United States  

  • ミクログリアと疼痛 Invited

    津田誠,井上和秀

    第52回日本神経化学会大会  2009.6 

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    Event date: 2009.6

    Presentation type:Symposium, workshop panel (public)  

    Venue:群馬・渋川   Country:Japan  

  • 難治性疼痛メカニズム解明への鍵となるミクログリア細胞 Invited

    津田誠,井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2009.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脊髄グリア細胞の役割から慢性痛のメカニズムを探る Invited

    津田誠,井上和秀

    第38回日本慢性疼痛学会  2009.2 

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    Event date: 2009.2

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • 慢性疼痛モデルで発現変動する分子の疼痛行動や細胞機能における役割の解析 Invited

    津田誠,井上和秀

    福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Regulation of neuropathic pain through activated microglia in the spinal cord Invited International conference

    Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 神経障害性疼痛-ミクログリアを中心とした病態メカニズム- Invited

    津田 誠

    第43回日本脊椎脊髄病学会学術集会  2014.4 

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    Language:Japanese  

    Venue:京都   Country:Japan  

  • 神経障害性疼痛と脊髄グリア細胞 Invited

    津田 誠, 井上 和秀

    日本ペインクリニック学会第47回大会  2013.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大宮   Country:Japan  

  • World First Discovery and Research-Neuropathic Pain, Neuralgia Invited

    2013.8 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:千葉   Country:Japan  

  • Purinergic signaling and chronic pain Invited International conference

    TSUDA MAKOTO

    Areces Foundation Symposium  2014.3 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Spain  

  • かゆみの慢性化における脊髄内メカニズム

    津田 誠, 井上 和秀

    第87回日本薬理学会年会  2014.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • ミクログリアに発現するATP受容体と神経因性疼痛 Invited

    津田誠,齊藤秀俊,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Role of spinal microglia in the pathogenesis of neuropathic pain

    2005.8 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • P2X4受容体発現制御因子と難治性疼痛

    津田誠,井上和秀

    第79回日本薬理学会年会  2006.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 神経およびグリア細胞培養系を利用した疼痛基礎研究

    津田誠

    第112回日本ペインクリニック学会  2006.7 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 慢性疼痛における脊髄グリア細胞の重要性 Invited

    津田誠,井上和秀

    第36回日本慢性疼痛学会  2007.2 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ATP受容体を介した難治性疼痛発症維持機構

    津田誠

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • ミクログリアのグリア伝達物質と神経因性疼痛 Invited

    津田誠,井上和秀

    第84回日本生理学会大会  2007.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Mechanisms underlying neuropathic pain through spinal microglia Invited

    2007.9 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Src-family tyrosine kinase Lyn in microglia contributes to neuropathic pain after peripheral nerve injury International conference

    Tsuda M, Masuda T, Tezuka T, Kitano J, Yamamoto T, Inoue K

    37th Annual Meeting Society for Neuroscience  2007.11 

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    Country:United States  

  • Role of microglial ATP receptors in neuropathic pain Invited International conference

    Tsuda M, Inoue K

    US-Japan joint meeting for glia research  2008.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Bidirectional modulation of somatosensory behavior by noradrenergic signaling through a spinal astrocyte population and inhibitory neurons

    Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Riku Kawanabe, Sawako Uchiyama, Makoto Tsuda

    THE 50th NAITO CONFERENCE  2023.10 

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    Event date: 2024.4

    Language:English  

    Country:Japan  

  • アストロサイト-神経相互作用を介した下行性疼痛制御機構の解明 Invited

    高露雄太,松田烈士,吉原康平,川邉陸,内山瑳和子,津田誠

    第45回日本疼痛学会  2023.12 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福島   Country:Japan  

  • 神経障害に伴う慢性疼痛の発症・維持機構 Invited

    津田誠

    第66回日本脳循環代謝学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • カンナビノイド受容体1遺伝子プロモーター活性を有する脊髄後角神経サブセットの神経障害性疼痛における役割

    井絵理子、大西晃央、末藤大智、津田誠

    日本薬学会第144年会  2024.3 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • ACSA2抗体と低温活性プロテアーゼを用いた新たな脊髄アストロサイト高純度単離法の確立

    岩﨑令真、高露雄太、津田誠

    日本薬学会第144年会  2024.3 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • CD11c陽性ミクログリアの増加は神経障害性疼痛の緩和を促進する

    河野敬太,白坂亮二,廣瀬恵太,芝田悠人,津田誠

    第97回日本薬理学会年会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • Proper distribution and proliferation of microglia involves mechanosensitive channel Piezo1

    Ayato Yamasaki, Makoto Tsuda, Takahiro Masuda

    2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 脳-脊髄トップダウンシグナルが神経障害性アロディニアに及ぼす影響の網羅的解析

    藤森一樹,齊藤秀俊,勢力薫,橋本均,津田誠

    第97回日本薬理学会年会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 神経障害性アロディニアに必要な脊髄後角抑制性神経の機能低下におけるアストロサイトの役割

    末藤大智,石橋忠幸,吉川優,山浦健,津田誠

    第97回日本薬理学会年会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • アルツハイマー病モデルマウスの脳内でのCD11c陽性ミクログリアの時空間解析

    野巻昂平,藤川理沙子,増田隆博,西道隆臣,齊藤貴志,津田誠

    第97回日本薬理学会年会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • Model of recurrent neuropathic pain by social defeat stress with underlying inflammatory responses

    Hidetoshi Tozaki-Saitoh, Takuya Hatta, Kazuhide Inoue, Makoto Tsuda

    2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • Aβ線維由来神経障害性アロディニアに重要な脊髄後角神経回路

    末藤大智,石橋忠幸,吉川優,田島諒一,山浦健,津田誠

    第45回日本疼痛学会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 神経損傷による慢性疼痛に重要な脊髄後角興奮性神経の同定

    大西晃央,末藤大智,井絵理子,津田誠

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • CD11c陽性ミクログリア由来IGF1の疼痛症状寛解作用機序の解析

    廣瀬恵大,河野敬太,津田誠

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 神経障害性疼痛を緩和に導く脊髄ミクログリア

    河野敬太,白坂亮二,廣瀬恵大,芝田悠人,津田誠

    第76回日本薬理学会西南部会  2023.10 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • Aβ神経線維を介する神経障害性アロディニアに重要な脊髄後角興奮性介在神経

    井絵理子,大西晃央,末藤大智,津田誠

    第76回日本薬理学会西南部会  2023.10 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 発達期から成体期におけるCD11c陽性ミクログリアの時空間解析

    野巻昂平,藤川理沙子,増田隆博,津田誠

    第76回日本薬理学会西南部会  2023.10 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 神経障害性アロディニアの発症に関与する脊髄後角興奮性神経

    井絵理子,大西晃央,末藤大智,津田誠

    第22回次世代を担う若手のためのファーマ・バイオフォーラム  2023.9 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 脊髄後角アストロサイト―神経相互作用による新規痛覚制御メカニズム

    川邉陸,内山瑳和子,津田誠

    第22回次世代を担う若手のためのファーマ・バイオフォーラム2023  2023.9 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 神経障害性アロディニアに関与する脊髄後角興奮性神経の同定

    大西晃央,末藤大智,井絵理子,津田誠

    第42回鎮痛薬・オピオイドペプチドシンポジウム  2023.9 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 痛覚伝達神経路におけるμオピオイド受容体恒常活性の短時間誘導法

    加納稜大、百木野和也、高露雄太、津田誠

    日本薬学会第143年会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 脊髄変化から紐解く痒みの慢性化機構 Invited

    白鳥美穂,津田誠

    第128回日本解剖学会総会・全国学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 脊髄アストロサイトから紐解く感覚情報伝達の調節メカニズム Invited

    高露雄太、松田烈士、吉原康平、津田誠

    日本生理学会第100回記念大会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 痒み慢性化における脊髄後角の反応性アストロサイトの役割 Invited

    白鳥美穂、津田誠

    日本生理学会第100回記念大会  2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 神経とアストロサイトを介した脊髄ノルアドレナリンによる両方向性の疼痛調節

    津田誠,川邉陸,内山瑳和子,吉原康平

    第44回日本疼痛学会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:岐阜   Country:Japan  

  • 脊髄後角における非細胞自律的な体性感覚情報処理 Invited

    高露雄太、松田烈士、吉原康平、津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脊髄後角ノルアドレナリンに関連した鎮痛効果に重要な脊髄後角抑制性神経サブセット

    末藤大智,石橋忠幸,吉川優,山浦健,津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • マウス外側腕傍核—扁桃体中心核痛み活性化ニューロン間シナプス伝達の痛み誘発増強

    内山瑳和子,奥田崇雄,高橋由香里,津田誠,加藤総夫

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 神経障害性アロディニアにおける大脳皮質-脊髄後角神経路の役割

    藤森一樹、津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • アストロサイト―神経相互作用を介した脊髄ノルアドレナリンによる双方向性痛覚制御

    川邉陸、吉原康平、津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 痒み伝達を担う脊髄神経サブセット Invited

    白鳥美穂、津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 痛覚刺激によるμオピオイド受容体の恒常活性化の誘導

    加納稜大、百木野和也、高露雄太、津田誠

    第39回日本薬学会九州山口支部大会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 神経障害性アロディニアにおける大脳皮質-脊髄後角経路の役割

    藤森一樹、津田誠

    第39回日本薬学会九州山口支部大会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • ミクログリアの組織内密度調節における機械感受性チャネルの役割

    山﨑絢斗、津田誠、増田隆博

    第75回日本薬理学会西南部会  2022.10 

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    Event date: 2022.10

    Language:Japanese  

    Venue:高知   Country:Japan  

  • α2δ-1 expressed in spinal dorsal horn excitatory neurons contributes to nerve injury-induced neuropathic pain

    2022.6 

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    Event date: 2022.5 - 2022.6

    Language:English  

    Venue:沖縄   Country:Japan  

  • 出生後の脳境界マクロファージの定着にはIrf8およびMafbが関与する

    山崎絢斗,津田誠,増田隆博

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • レセルピン誘発線維筋痛症モデルにおけるミクログリアの役割

    齊藤秀俊,細井昌子,津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • ストレス誘発性鎮痛におけるノルアドレナリンシグナルの関与

    内山瑳和子,吉原康平,川邉陸,古賀啓祐,津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • 神経障害性アロディニアに重要な脊髄後角抑制性神経の変化に対するアストロサイトの役割

    末藤大智,石橋忠幸,吉川優,山浦健,津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • ハイスループットスクリーニングにより新たに発見されたMRGPRA3アゴニストは引っ掻き行動を誘発する

    山下智大,伊藤麻結,川浪侑華,古賀啓介,兼久賢章,藤井志織,カアベイロホセ,津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • 脊髄後角アストロサイトのαおよびβ受容体を介する異なる痛覚制御

    吉原康平,川邉陸,内山瑳和子,白坂亮二,古賀啓祐,津田誠

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡*ハイブリッド   Country:Japan  

  • 慢性ストレス誘発性痛覚過敏における脊髄後角アストロサイトサブセットを介したノルアドレナリン神経シグナルの役割

    吉原康平,津田誠

    第43回日本疼痛学会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知*オンライン   Country:Japan  

  • Aβ神経線維を介する神経障害性アロディニアに重要な脊髄後角サブセット

    末藤大智,石橋忠幸,吉川優,田島諒一,山浦健,津田誠

    第74回日本薬理学会西南部会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • 痛覚を調節する脳-脊髄後角トップダウン神経路の網羅的解析

    藤森一樹,齊藤秀俊,勢力薫,橋本均,津田誠

    第74回日本薬理学会西南部会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • ストレス誘発性鎮痛におけるノルアドレナリンシグナルの関与

    内山瑳和子,吉原康平,川邉陸,古賀啓祐,津田誠

    第38回日本薬学会九州山口支部大会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本*オンライン   Country:Japan  

  • 侵害刺激は下行性ノルアドレナリン神経シグナルを介して脊髄後角アストロサイトを活性化する

    川邉陸,吉原康平,津田誠

    第64回日本神経化学会大会  2021.9 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良*オンライン   Country:Japan  

  • 慢性掻痒時のアストロサイトSTAT3の持続的活性化における一次求心性神経由来IL-6とIP3R1/TRPC依存的なカルシウムシグナルの関与

    白鳥美穂,山口千春,江口和志,豊永穂奈美,津田誠

    生体機能と創薬シンポジウム2020-2021  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌*ハイブリッド   Country:Japan  

  • 青斑核由来下行性ノルアドレナリン神経による痒み抑制メカニズム

    白石悠人,古賀啓佑,白鳥美穂,津田誠

    生体機能と創薬シンポジウム2020-2021  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌*ハイブリッド   Country:Japan  

  • 動物モデルを用いた心理社会的ストレスと痛みの科学的理解へのアプローチ Invited

    齊藤秀俊,津田誠

    第62回日本心身医学会総会ならびに学術講演会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:高松   Country:Japan  

  • 神経障害性疼痛におけるミクログリアサブセットの役割

    河野敬太,津田誠

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:広島*オンライン   Country:Japan  

  • 神経障害性疼痛回復期に出現するミクログリアサブポピュレーション

    河野敬太,津田誠

    第94回薬理学会年会  2021.3 

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    Event date: 2021.3

    Language:English  

    Venue:札幌*ハイブリッド   Country:Japan  

  • 侵害刺激による脊髄後角アストロサイトの活性化には下行性ノルアドレナリン神経シグナルが関与する

    川邉陸,吉原康平,津田誠

    第94回薬理学会年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:札幌*ハイブリッド   Country:Japan  

  • 一次求心性神経由来NPTX2は脊髄後角GRPR陽性神経への興奮性シナプス入力の増大と慢性掻痒に関与する

    兼久賢章,津田誠

    第42回日本疼痛学会  2020.12 

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    Event date: 2020.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 脊柱管狭窄症由来の下肢痛における脊髄後角アストロサイトの役割

    大野瑛明,中島康晴,津田誠

    第42回日本疼痛学会  2020.12 

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    Event date: 2020.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 痒みにおける青斑核由来下行性ノルアドレナリン神経の役割

    白石悠人,古賀啓祐,白鳥美穂,津田誠

    第73日本薬理学会西南部会  2020.11 

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    Event date: 2020.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 脊柱管狭窄に伴う慢性疼痛発症における脊髄後角アストロサイトの役割

    大野瑛明,津田誠,中島康晴

    第35回日本整形外科学会基礎学術集会  2020.10 

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    Event date: 2020.10

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 脊柱管狭窄に伴う慢性疼痛発症における脊髄後角アストロサイトの役割

    大野瑛明,中島康晴,津田誠

    第63日本神経化学会大会  2020.9 

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    Event date: 2020.9

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 脊髄後角アストロサイトを介した下行性ノルアドレナリン神経による新たな体性感覚制御メカニズム

    吉原康平,高露雄太,松田烈士,齊藤秀俊,井上和秀,津田誠

    第93回日本薬理学会年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • ノルアドレナリンによるミクログリアのインターロイキン1β産生はEPAC、MAP3K8によって調節される

    齊藤秀俊,笹木泉,山下智大,津田誠

    第93回日本薬理学会年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 新規MrgprA3アゴニストの発見およびかゆみ感覚に対するその評価

    山下智大,伊藤麻結,川浪侑華,古賀啓介,兼久賢章,藤井志織,白鳥美穂,津田誠

    第93回日本薬理学会年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • A subset of dorsal horn inhibitory interneurons has a critical role in mechanical allodynia after nerve injury Invited International conference

    Keisuke Koga, Ryoichi Tashima, Yuta Kohro, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda

    8th Asian pain symposium  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • 慢性掻痒時の活性化アストロサイトによる痒み増強メカニズム

    山方涼,古賀啓祐,白鳥美穂,津田誠

    第36回日本薬学会九州支部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • ミクログリアサブセットの神経障害性疼痛における新しい役割

    河野敬太、津田誠

    第72回日本薬理学会西南部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:沖縄   Country:Japan  

  • 心理社会的ストレスが慢性疼痛病態モデルに及ぼす影響 Invited

    齊藤秀俊,津田誠

    第35回日本ストレス学会学術総会  2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Investigation of neuropathic allodynia with sensory and emotional components using an optogenetic approach International conference

    Makoto Tsuda, Ryoichi Tashima, Keisuke Koga, Hiromu Yawo, Hidemasa Furue

    2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • New role of a subset of spinal cord microglia in neuropathic pain International conference

    Keita Kohno, Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • Papaverine potently activates MrgprA3 and produces scratching behavior International conference

    Tomohiro Yamashita, Mayu Ito, Yuka Kawanami, Keisuke Koga, Kensho Kanehisa, Shiori Fujii, Miho Shiratori-Hayashi, Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • Sensitization of GRPR-expressing dorsal horn neurons under chronic itch condition requires astrocyte-derived signaling International conference

    Keisuke Koga, Ryo Yamagata, Miho Shiratori-Hayashi and Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • Excitatory synaptic responses in GRPR+ dorsal horn neurons are increased in a mouse model of atopic dermatitis International conference

    Kensho Kanehisa, Keisuka Koga, Shiori Fujii, Miho Shiratori-Hayashi, Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • Descending noradrenergic pathway modulates mechanosensory behavior via spinal dorsal horn astrocytes International conference

    Kohei Yoshihara, Yuta Kohro, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • Mechanism underlying STAT3 activation in astrocytes under chronic itch conditions International conference

    Miho Shiratori-Hayashi, Chiharu Yamaguchi, Kazushi Eguchi, Honami Toyonaga, Makoto Tsuda

    THE 48th NAITO CONFERENCE  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Country:Japan  

  • 慢性疼痛動物モデルの病態発症・維持機構に対するミクログリアの関与 Invited

    齊藤秀俊,津田誠

    日本線維筋痛症学会第11回学術集会  2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 慢性掻痒モデルマウスでは脊髄後角GRPR陽性神経への興奮性シナプス入力が増加する

    兼久賢章、古賀啓祐、白鳥美穂、津田誠

    生体機能とシンポジウム2019  2019.8 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Activated astrocytes in the spinal dorsal horn facilitate itch transmission in a mouse model of contact dermatitis

    Keisuke Koga, Ryo Yamagata, Miho Shiratori-Hayashi, Makoto Tsuda

    2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Country:Japan  

  • Social defeat stress modulates nocifensive response in remission phase of chronic pain models

    Hidetoshi Tozaki-Saitoh, Takuya Hatta, Makoto Tsuda

    2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Country:Japan  

  • 脊髄後角アストロサイトを介した下行性ノルアドレナリン神経による体性感覚制御

    吉原康平、高露雄太、松田烈士、齋藤秀俊、津田誠

    第41回日本疼痛学会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • アトピー性皮膚炎モデルマウスにおける脊髄後角GRPR陽性神経への興奮性シナプス入力の増強

    兼久賢章,古賀啓祐,藤井志織,白鳥美穂,津田誠

    第41回日本疼痛学会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 心理社会的ストレスによる慢性疼痛の変調:ミクログリアの関与 Invited

    齊藤秀俊,津田誠

    第115回日本精神神経学会学術総会  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:新潟   Country:Japan  

  • Aβ線維を介する神経障害性アロディニアに関与する脊髄後角第II層神経サブセット

    津田誠,田島諒一,古賀啓祐

    第13回日本緩和医療薬学会年会  2019.6 

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    Event date: 2019.5 - 2019.6

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • Aβ線維由来神経障害性アロディニアに関与する脊髄後角第II層神経サブセットの同定

    田島諒一,古賀啓祐,渡邊萌佳,関根美鈴,津田誠

    日本薬学会第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • 脊髄後角アストロサイトの活性化は、接触性皮膚炎モデルマウスにおいて痒み伝達を増強する

    古賀啓祐,山方涼,白鳥美穂,津田誠

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • アトピー性皮膚炎モデルマウスにおける脊髄後角GRPR陽性神経細胞への興奮性シナプス入力の増強

    兼久賢章,古賀啓祐,藤井志織,白鳥美穂,津田誠

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 転写因子MafBは脊髄ミクログリアの活性化と神経障害性疼痛に関与する

    齊藤秀俊、増田潤哉、米田聡介、小嶋ちなみ、川田竜、井上和秀、津田誠

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 乳がん治療薬フルベストラントはオキサリプラチン誘発末梢神経障害を抑制する

    山本将大,山下智大,伊藤麻結,ホセ・カーベイロ,江頭伸昭,齊藤秀俊,津田誠

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 神経障害性アロディニアに関与する一次求心性Aβ線維サブセット

    渡邊萌佳,田島諒一,関根美鈴,津田誠

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 一次求心性神経由来LGALS3の神経障害性疼痛および慢性掻痒病態への関与

    鷲頭加歩,河野敬太,白鳥美穂,津田誠

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 神経障害性疼痛における脊髄ミクログリアの活性化タイムコース

    河野敬太,北野順子,高露雄太,齊藤秀俊,井上和秀,津田誠

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • アドレナリン受容体を介したミクログリアの炎症応答調節

    笹木泉、齊藤秀俊、津田誠

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 脊髄後角ミクログリアの転写因子MafBは末梢神経障害後の神経障害性疼痛発症に関与する

    齊藤秀俊、増田潤哉、川田竜、小嶋ちなみ、米田聡介、井上和秀、津田誠

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 感覚情報伝達における脊髄後角アストロサイト亜集団の役割

    高露雄太, 松田烈士, 吉原康平, 桂木龍一, 岡嵩晃, 田島諒一, 棟田翔, 山根拓也, 齊藤秀俊, 御子柴克彦, Verdon Taylor, 井上和秀, 津田誠

    第71回日本薬理学会西南部会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 神経障害性疼痛寛解期の社会的敗北ストレス負荷は痛覚閾値の再低下を引き起こす

    齊藤秀俊,八田拓哉,井上和秀,津田誠

    第71回日本薬理学会西南部会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 脊髄後角GRPR陽性神経活動と慢性掻痒におけるアストロサイトの役割

    山方涼,古賀啓祐,白鳥美穂,津田誠

    第71回日本薬理学会西南部会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • ACSA2抗体を用いた脊髄アストロサイト単離法の確立

    山根拓也,高露雄太,津田誠

    第71回日本薬理学会西南部会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Sensitizing mechanosensory information by a population of spinal dorsal horn astrocytes International conference

    Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Ryuichi Katsuragi,Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

    17th World Congress on Pain (IASP 2018)  2018.9 

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    Event date: 2018.9

    Language:Japanese  

    Country:Japan  

  • アロディニアの発症に関与する脊髄後角第II層神経サブポピュレーションの特定

    田島諒一,古賀啓祐,渡邊萌佳,関根美鈴,津田誠

    第17回 次世代を担う若手ファーマ・バイオフォーラム2018  2018.9 

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    Event date: 2018.9

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • Rapid and selective inhibition of dorsal horn inhibitory interneurons induces morphine-resistant spontaneous nocifensive behaviors International conference

    Keisuke Koga, Kensho Kanehisa, Tozaki-Saitoh Hidetoshi, Hidemasa Furue, Makoto Tsuda

    2018.7 

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    Event date: 2018.7

    Language:Japanese  

    Country:Japan  

  • Social defeat stress arouses recurrence of pain in ameliorationg state International conference

    Hidetoshi Saitoh, Takuya Hatta, Kazuhide Inoue, Makoto Tsuda

    2018.6 

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    Event date: 2018.7

    Language:Japanese  

    Country:Japan  

  • Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats International conference

    18th World Congress of Basic and Clinical Pharmacology (WCP2018)  2018.7 

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    Event date: 2018.7

    Language:Japanese  

    Venue:京都   Country:Japan  

  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury International conference

    18th World Congress of Basic and Clinical Pharmacology (WCP2018)  2018.7 

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    Event date: 2018.7

    Language:Japanese  

    Venue:京都   Country:Japan  

  • アロディニアの発症に関与する脊髄後角第II層神経サブポピュレーションの特定

    田島諒一,渡邊萌佳,関根美鈴,津田誠

    第40回日本疼痛学会  2018.6 

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    Event date: 2018.6

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 脊髄後角アストロサイトを介したノルアドレナリンによる新しい感覚情報制御

    吉原康平,松田烈士,齊藤秀俊,高露雄太,津田誠

    日本薬学会第138年会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 転写因子MafBは末梢神経障害後の脊髄後角ミクログリアの活性化を調節し神経障害性疼痛に関与する

    齊藤秀俊,増田潤哉,小嶋ちなみ,米田聡介,川田竜,井上和秀,津田誠

    第39回日本疼痛学会  2017.6 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 脊髄後角抑制性介在神経の急性的な抑制はモルヒネ抵抗性の自発的疼痛関連行動を引き起こす

    古賀啓祐,兼久賢章,高露雄太,齋藤秀俊,井上和秀,古江秀昌,津田誠

    第39回日本疼痛学会  2017.6 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • D-セリンシグナルを介した脊髄後角アストロサイトによる触覚情報の変調作用

    高露雄太,桂木龍一,岡嵩晃,棟田翔,田島諒一,齊藤秀俊,御子柴克彦,井上和秀,津田誠

    第39回日本疼痛学会  2017.6 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • Specific activation of GABAergic interneurons in the cervical spinal dorsal horn suppresses chronic itch

    2017.9 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • The role of region-specific spinal dorsal horn astrocytes in sensory information processing

    2017.9 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 頸部脊髄後角抑制性介在ニューロンの活性化による慢性的なかゆみの改善

    兼久賢章,白鳥美穂,古賀啓祐,高露雄太,津田誠

    第70回日本薬理学会西南部会  2017.11 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 脊髄後角アストロサイトの痛覚調節への関与

    吉原康平,松田烈士,齊藤秀俊,高露雄太,津田誠

    第70回日本薬理学会西南部会  2017.11 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 慢性掻痒に関与する脊髄後角神経伝達シグナル

    遠山かほり,白鳥美穂,津田誠

    第34回日本薬学会九州支部大会  2017.11 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 神経障害性アロディニアに関与する一次求心性Aβ線維:光遺伝学的解析

    関根美鈴,田島諒一,古賀啓祐,八尾寛,井上和秀,古江秀昌,津田誠

    第138回日本薬理学会関東部会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 脊髄後角アストロサイトCa2+シグナルは感覚情報伝達に関与する

    松田烈士,吉原康平,齊藤秀俊,高露雄太,津田誠

    日本薬学会第138年会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • オキサリプラチン誘発末梢神経障害における脊髄グルタミン酸濃度の恒常性破綻と既承認薬リルゾールの保護効果

    山本将大,江頭伸昭,増田智先,津田誠

    日本薬学会第138年会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • デュロキセチンによるミクログリアに発現するP2X4受容体の阻害作用および末梢神経損傷に伴う神経障害性疼痛に対する改善効果

    山下 智大ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 転写因子MafBは脊髄活性化ミクログリアに発現し神経障害性疼痛発症に関与する

    齊藤 秀俊ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 慢性掻痒におけるアストロサイトSTAT3の活性化メカニズム

    山口千春ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 頸髄後角の抑制性介在ニューロン活性化は接触性皮膚炎モデルにおける慢性掻痒を抑制する

    兼久 賢章ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • D-セリンシグナルを介した脊髄後角アストロサイトによる様式特異的な感覚情報処理への関与

    高露 雄太ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • MrgprA3陽性一次求心性神経に発現するP2X3受容体の活性化はGRP受容体依存的な痒みを発症する

    白鳥 美穂ら

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • Purinergic receptor P2X3 in MrgprA3-positive sensory neurons mediates the itch sensation through a pathway involving GRP receptors International conference

    Miho Shiratori-Hayashi et al.

    46th Annual Meeting Society for Neuroscience  2016.11 

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    Event date: 2016.11

    Language:English  

    Country:United States  

  • Activation of spinal dorsal horn astrocytes modulates the processing of tactile sensation International conference

    Yuta Kohro et al.

    46th Annual Meeting Society for Neuroscience  2016.11 

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    Event date: 2016.11

    Language:English  

    Country:United States  

  • 脊髄後角アストロサイトの活動変化は触覚情報を変調させる

    高露 雄太ら

    第60回日本神経化学会大会  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • DREADDを用いた脊髄アストロサイトの感覚情報伝達における機能解析

    高露 雄太ら

    第38回日本疼痛学会  2016.6 

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    Event date: 2016.6

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • パクリタキセル誘発末梢神経障害に対するポラプレジンクの効果

    堤国章ら

    日本薬学会第136年会  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Role of STAT3-dependent reactive astrocytes in the spinal dorsal horn in chronic itch International conference

    XII European Meeting on Glial Cells in Health and Disease  2015.7 

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    Event date: 2016.5

    Language:English  

    Country:Spain  

  • P2X3R-positive sensory neurons are involved in itch sensation through a pathway involving GRP receptors International conference

    8th World Congress on Itch (WCI 2015)  2015.9 

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    Event date: 2016.5

    Language:English  

    Country:Japan  

  • Astrocytic lipocalin-2 in the spinal dorsal horn is required for chronic itch International conference

    8th World Congress on Itch (WCI 2015)  2015.9 

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    Event date: 2016.5

    Language:English  

    Country:Japan  

  • STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice International conference

    45th Annual Meeting Society for Neuroscience  2015.10 

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    Event date: 2016.5

    Language:English  

    Country:United States  

  • 筋萎縮性側索硬化症治療薬リルゾールはオキサリプラチン誘発機械的アロディニアおよび脊髄グルタミン酸放出増加を抑制する

    山本将大ら

    第89回日本薬理学会年会  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • VGAT陽性脊髄後角抑制性介在ニューロンの抑制によって自発通関連行動が誘発される

    古賀啓祐ら

    第89回日本薬理学会年会  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 脊髄アストロサイトの活動変化は感覚情報を様式特異的に変調させる

    高露 雄太ら

    第89回日本薬理学会年会  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に関与する

    白鳥 美穂ら

    日本薬学会第136年会  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 光遺伝学的手法を用いた一次求心性神経Aβ線維を介する神経障害性アロディニアの新規評価法

    田島諒一ら

    第89回日本薬理学会年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 活性化ミクログリアにおける転写因子IRF1の役割

    御厨颯季ら

    第32回日本薬学会九州支部大会  2015.11 

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    Event date: 2015.11

    Language:Japanese  

    Venue:延岡   Country:Japan  

  • 光遺伝学的手法による神経障害性アロディニアの新規評価法

    田島諒一ら

    第68回日本薬理学会西南部会  2015.11 

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    Event date: 2015.11

    Language:Japanese  

    Venue:山口   Country:Japan  

  • アトピー性皮膚炎モデルマウスの慢性的な痒みにおける脊髄後角アストロサイトの関与

    津田 誠ら

    第45回日本神経精神薬理学会  2015.9 

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    Event date: 2015.9

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Essential role for STAT3-dependent reactive astrocytes in maintenance of chronic itch

    2015.9 

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    Event date: 2015.9

    Language:English  

    Country:Japan  

  • In vivo Ca2+ imaging reveals that spinal astrocytes respond to nociceptor stimulation

    2015.9 

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    Event date: 2015.9

    Language:English  

    Country:Japan  

  • 神経損傷後の一次求心性神経Aβ線維を介する疼痛関連行動:光遺伝学的アプローチを用いた神経障害性疼痛の新しい評価法

    田島諒一ら

    第37回日本疼痛学会  2015.7 

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    Event date: 2015.7

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • ミクログリアに発現するP2X4 受容体を標的とした神経障害性疼痛治療薬の探索

    山下 智大ら

    日本薬学会第135年会  2015.3 

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    Event date: 2015.3

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • ATP受容体を標的にしたエコファーマ~慢性疼痛の克服を目指して~ Invited

    津田 誠ら

    日本薬学会第135年会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • アンメット・メディカル・ニーズの高い難治性疾患に対するアカデミック創薬:九州大学拠点の取り組み Invited

    津田 誠ら

    日本薬学会第135年会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • ATP受容体を標的とした新規治療薬の探索に向けた新しい創薬システム「グリーンファルマ」の取り組み Invited

    山下 智大ら

    第8回次世代を担う若手医療薬科学  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • ATP受容体を標的とした新規治療薬の探索に向けた新しい創薬システム「グリーンファルマ」の取り組み Invited

    山下 智大ら

    第8回次世代を担う若手医療薬科学  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • ミクログリアの細胞膜P2X4受容体の発現制御に対するP2X7受容体の関与

    山下 智大, 津田 誠, 齊藤 秀俊, 井上 和秀

    日本薬学会第133回年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • パクリタキセル誘発慢性疼痛における脊髄内CCL3の関与

    落石龍太郎, 津田 誠, 永田健一郎, 矢野貴之, 井上智之, 齊藤 秀俊, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • スクリーニングシステムを利用したP2X4受容体を標的とした鎮痛薬の探索

    山下 智大, 長谷川あゆみ, 冨永桂子, 上加世田紗和子, 張佳明, 津田 誠, 齊藤 秀俊, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • P2X4受容体のマイクログリア膜トラフィッキング制御 Invited

    Hidetoshi Saitoh, 津田 誠, 山下 智大, 井上 和秀

    第86回日本薬理学会年会  2013.3 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Role of P2X7 receptors in regulation of P2X4 receptors expression on the plasma membrane of microglia International conference

    2012.9 

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    Event date: 2012.9 - 2012.10

    Language:English  

    Country:Japan  

  • Transcription factor MafB mediates activation process of spinal microglia that contributes to neuropathic pain development International conference

    Hidetoshi Saitoh, Junya Masuda, TSUDA MAKOTO, Kazuhide Inoue

    2012.9 

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    Event date: 2012.9 - 2012.10

    Language:English  

    Country:Japan  

  • DAP12およびCARD9ノックアウトマウスによる神経障害痛モデルの組織学的検討

    村田祐造, 八坂敏一, 原博満, 李明子, 藤田亜美, 津田 誠, 井上 和秀, 熊本栄一, 吉田裕樹, 増子貞彦

    第35回日本神経科学大会Neuro2012  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 活性化ミクログリア細胞でのP2X7受容体によるP2X4受容体の細胞膜表面における発現レベルの調節

    山下 智大, 津田 誠, 齊藤 秀俊, 井上 和秀

    第34回日本疼痛学会  2012.7 

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    Event date: 2012.7

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • Role of P2X7 Receptors in Regulation of P2X4 Receptors Expression on the Plasma Membrane of Microglia International conference

    Purine 2012  2012.6 

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    Event date: 2012.5 - 2012.6

    Language:English  

    Country:Japan  

  • CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia Invited International conference

    Purine 2012  2012.5 

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    Event date: 2012.5 - 2012.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Involvement of Protein Kinase D in UDP-Induced Microglial Macropinocytosis and Phagocytosis International conference

    Ayumi Uesugi, Ayako Kataoka, Hidetoshi Saitoh, TSUDA MAKOTO, Kazuhide Inoue

    Purine 2012  2012.6 

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    Event date: 2012.5 - 2012.6

    Language:English  

    Country:Japan  

  • デュロキセチンの神経障害性疼痛抑制メカニズムを考える Invited

    津田 誠

    第53回日本神経学会学術大会  2012.5 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ミクログリア活性化における転写因子MafBの役割

    米田聡介,齊藤秀俊,増田潤哉,津田誠,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Venue:京都市   Country:Japan  

  • ミクログリアの細胞膜P2X4受容体の発現制御に対するP2X7受容体の関与

    山下智大,津田誠,齊藤秀俊,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Venue:京都市   Country:Japan  

  • 神経障害性疼痛の緩和における脊髄CB2受容体の役割

    下山裕,増田隆博,吉永遼平,西本奈央,齊藤秀俊,津田誠,井上和秀

    第85回日本薬理学会年会  2012.3 

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    Event date: 2012.3

    Venue:京都市   Country:Japan  

  • 脊髄ミクログリア細胞から探る慢性疼痛メカニズム Invited

    津田誠,井上和秀

    第21回神経行動薬理若手研究者の集い  2012.3 

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    Event date: 2012.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • 神経障害性疼痛におけるミクログリアの転写因子MafBの役割

    米田聡介,増田潤哉,齊藤秀俊,津田 誠,井上和秀

    第39回薬物活性シンポジウム  2011.11 

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    Event date: 2011.11

    Venue:福岡県福岡市   Country:Japan  

  • 神経障害性疼痛におけるミクログリアP2Y12 受容体の関与

    齊藤秀俊,宮田広行,津田 誠,井上和秀

    第39回薬物活性シンポジウム  2011.11 

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    Event date: 2011.11

    Venue:福岡県福岡市   Country:Japan  

  • 神経障害性疼痛モデルにおいて脊髄ミクログリア特異的に発現する転写因子MafBの役割

    増田潤哉、齊藤秀俊、米田聡介、津田 誠、井上和秀

    第64回日本薬理学会西南部会  2011.11 

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    Event date: 2011.11

    Venue:福岡県福岡市   Country:Japan  

  • UDP誘発性のミクログリアによるマクロピノサイトーシスへのPKDの関与

    上杉歩未,片岡彩子,齊藤秀俊,津田誠,井上和秀

    第54回日本神経化学会大会  2011.9 

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    Event date: 2011.9

    Venue:石川県山代温泉   Country:Japan  

  • 初代培養ミクログリアにおけるP2Y12受容体を介したケモカインの発現制御

    齊藤秀俊,津田誠,井上和秀

    第54回日本神経化学会大会  2011.9 

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    Event date: 2011.9

    Venue:石川県山代温泉   Country:Japan  

  • Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development International conference

    Biber, K.; Tsuda, M.; Tozaki-Saitoh, H.; Tsukamoto, K.; Toyomitsu, E.; Masuda, T.; Boddeke, H.; Inoue, K

    10th Euroglia Meeting on Glial Cells in Health and Diseases  2011.9 

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    Event date: 2011.9

    Country:Czech Republic  

  • 初代培養ミクログリアにおけるP2Y12受容体を介したCCL3ケモカインの発現制御

    宮田広行,齊藤秀俊,津田誠,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • UDP刺激誘発性のミクログリア貪食におけるPKDの関与

    片岡彩子,上杉歩未,齊藤秀俊,津田誠,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • CTPによるミクログリアにおけるP2X4受容体の機能評価

    山下 智大, 津田 誠, 齊藤 秀俊, 井上 和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • 転写因子IRF8によるミクログリア遺伝子発現プログラムを介した神経障害性疼痛制御

    増田隆博,津田誠,吉永遼平,田村智彦,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • 神経障害性疼痛モデルマウスにおける活性化型脊髄ミクログリアは高い遊走能を有する

    増田潤哉,齊藤秀俊,津田誠,井上和秀

    第84回日本薬理学会年会  2011.3 

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    Event date: 2011.3

    Venue:横浜   Country:Japan  

  • 抗ラットP2X4抗体の調製とエピトープ解析

    井川達弘,阿部義人,東貞行,津田誠,井上和秀,植田正

    第27回日本薬学会九州支部大会  2010.12 

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    Event date: 2010.12

    Venue:長崎   Country:Japan  

  • Glial cells and pain control Invited

    Makoto Tsuda, Kazuhide Inoue

    Busan-Kyushu International Joint Seminar  2010.11 

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    Event date: 2010.11

    Presentation type:Symposium, workshop panel (public)  

    Country:Korea, Republic of  

  • Glial cells and pain control Invited

    2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 神経障害性疼痛とミクログリアの活性化 Invited

    津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • Interferon regulatory factor-8はミクログリア由来疼痛関連分子の発現を誘導する転写因子である

    増田隆博,津田誠,吉永遼平,田村智彦,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • 神経障害性疼痛発症における脊髄CCL3の関与

    齊藤秀俊,津田誠,上田和明,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • 急性脳スライスにおけるミクログリアの状態のリアルタイムイメージング解析

    増田潤哉,齋藤秀俊,津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • CTPによるミクログリアにおけるP2X4受容体の機能評価

    山下智大,津田誠,齊藤秀俊,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • ミクログリアにおけるP2X7受容体活性化はNFATとPKC/MAPKを介してCXCL2産生に関与する

    白鳥美穂,齊藤秀俊,吉武麻衣,津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • UDPによるミクログリアの貪食促進作用におけるPKDの関与

    片岡彩子,齊藤秀俊,上杉歩未,古賀結衣,津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • 脊髄ミクログリアの活性化がパクリタキセル誘発機械刺激過敏、冷刺激過敏及び運動機能障害を引き起こす

    永田健一郎,井上智之,矢野貴之,高露雄太,大石了三,津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • 神経障害性疼痛の維持機構におけるSTAT3の役割

    高露雄太,津田誠,矢野貴之,辻川智子,北野順子,齊藤秀俊,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • 神経障害性疼痛の緩和における脊髄内CB2受容体とその下流メカニズムの重要性

    下山裕,塚本恵子,齊藤秀俊,津田誠,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • CCL2シグナルを介したフィブロネクチン刺激によるミクログリアP2X4受容体の膜移行

    豊満笑加,津田 誠,齊藤秀俊,井上和秀

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  2010.9 

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    Event date: 2010.9

    Venue:神戸   Country:Japan  

  • Spinal microglia: a key component in neuropathic pain Invited International conference

    Makoto Tsuda, Kazuhide Inoue

    The 13th Asian Australasian Congress of Anesthesiologists  2010.6 

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    Event date: 2010.6

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Role of interferon regulatory factor-8 in the pathogenesis of neuropathic pain International conference

    Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Tomohiko Tamura, Kazuhide Inoue

    Purines 2010  2010.6 

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    Event date: 2010.5 - 2010.6

    Country:Spain  

  • CCR2 enhances P2X4 receptor trafficking to the plasma membrane of microglia International conference

    Emika Toyomitsu, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue

    Purines 2010  2010.6 

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    Event date: 2010.5 - 2010.6

    Country:Spain  

  • Involvement of PKD in UDP-stimulated microglial phagocytosis International conference

    Ayako Kataoka, Hidetoshi Tozaki-Saitoh, Yui Koga, Ayumi Uesugi, Makoto Tsuda, Kazuhide Inoue

    Purines 2010  2010.6 

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    Event date: 2010.5 - 2010.6

    Country:Spain  

  • P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways International conference

    Miho Shiratori, Hidetoshi Tozaki-Saitoh, Mai Yoshitake, Makoto Tsuda, Kazuhide Inoue

    Purines 2010  2010.6 

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    Event date: 2010.5 - 2010.6

    Country:Spain  

  • Analysis of microglial activation in tissue slice using two-photon imaging International conference

    Junya Masuda, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue

    Purines 2010  2010.6 

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    Event date: 2010.5 - 2010.6

    Country:Spain  

  • 神経障害性疼痛におけるinterferon regulatory factor-8の役割

    増田隆博,津田誠,吉永遼平,田村智彦,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • UDP誘発ミクログリアの貪食反応におけるPKDの関与

    片岡彩子,齊藤秀俊,古賀結衣,上杉歩未,津田誠,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • CCL2はミクログリア細胞膜上でのP2X4受容体発現を増加する

    豊満笑加,津田誠,山下智大,齊藤秀俊,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • 神経障害性疼痛発症時の脊髄CCL3の関与

    齊藤秀俊,上田和明,津田誠,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • UDP誘発性ミクログリア貪食作用におけるVASPリン酸化の関与

    古賀結衣,片岡彩子,齊藤秀俊,津田誠,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • ミクログリア貪食時における一過性のカルシウム上昇

    齊藤秀俊,津田誠,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • ミクログリアからのATP誘発CXCL2放出メカニズム

    白鳥美穂,齊藤秀俊,吉武麻衣,津田誠,井上和秀

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Venue:大阪   Country:Japan  

  • 神経障害性疼痛治療薬としてのミクログリア活性化阻害剤 Invited

    井上和秀,津田誠

    第83回日本薬理学会年会  2010.3 

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    Event date: 2010.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • ミクログリアからのATP誘発CXCL2放出メカニズム

    白鳥美穂,齊藤秀俊,吉武麻衣,津田誠,井上和秀

    第62回日本薬理学会西南部会  2009.11 

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    Event date: 2009.11

    Venue:愛媛・松山   Country:Japan  

  • 神経障害性疼痛の維持におけるSTAT3の役割

    高露雄太,津田誠,矢野貴之,辻川智子,北野順子,齊藤秀俊,井上和秀

    第62回日本薬理学会西南部会  2009.11 

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    Event date: 2009.11

    Venue:愛媛・松山   Country:Japan  

  • 脊髄CB2受容体の活性化による神経因性疼痛抑制メカニズム

    下山裕,塚本恵子,齊藤秀俊,津田誠,井上和秀

    第3回次世代を担う若手医療薬科学シンポジウム  2009.11 

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    Event date: 2009.11

    Venue:福岡   Country:Japan  

  • 抗うつ薬による神経因性疼痛寛解作用とそのメカニズムの解析

    米谷美穂,松村祐太,永田健一郎,津田誠,井上和秀

    第3回次世代を担う若手医療薬科学シンポジウム  2009.11 

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    Event date: 2009.11

    Venue:福岡   Country:Japan  

  • Glial Function and pain signaling Invited International conference

    Makoto Tsuda, Kazuhide Inoue

    Kyushu Brain days  2009.11 

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    Event date: 2009.11

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脊髄ミクログリア活性化と神経因性疼痛 Invited

    井上和秀,津田誠

    第31回日本疼痛学会 / 名古屋ペイン2009  2009.7 

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    Event date: 2009.7

    Presentation type:Oral presentation (general)  

    Venue:愛知・名古屋   Country:Japan  

  • 脊髄CB2受容体の活性化による神経因性疼痛抑制メカニズム

    下山裕,津田誠,齊藤秀俊,井上和秀

    第31回日本疼痛学会 / 名古屋ペイン2009  2009.7 

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    Event date: 2009.7

    Venue:名古屋   Country:Japan  

  • 血小板由来増殖因子PDGF誘発アロディニアにおける脊髄ミクログリアの関与

    増田潤哉,津田誠,齊藤秀俊,井上和秀

    第52回日本神経化学会大会  2009.6 

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    Event date: 2009.6

    Venue:群馬   Country:Japan  

  • フィブロネクチン刺激ミクログリアにおけるP2X4受容体発現増加の翻訳および翻訳後制御

    豊満笑加,津田誠,齊藤秀俊,井上和秀

    第52回日本神経化学会大会  2009.6 

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    Event date: 2009.6

    Venue:群馬   Country:Japan  

  • 神経因性疼痛に重要な脊髄後角ミクログリアの活性化メカニズム Invited

    津田誠,増田隆博,井上和秀

    第18回神経行動薬理若手研究者の集い  2009.3 

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    Event date: 2009.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 末梢神経損傷によるCa2+/カルモジュリン依存性プロテインキナーゼIIを介した細胞質型ホスホリパーゼA2の活性化

    長谷川茂雄,高露雄太,津田誠,井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2009.3

    Venue:横浜   Country:Japan  

  • 神経損傷による脊髄アストロサイトの活性化と神経因性疼痛に対するSTAT3の役割

    辻川智子、津田誠、矢野貴之、井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2009.3

    Venue:横浜   Country:Japan  

  • 脊髄における血小板由来増殖因子PDGFはミクログリアのPDGF受容体を介してアロディニアを発現する

    増田潤哉,津田誠,齊藤秀俊,井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2009.3

    Venue:横浜   Country:Japan  

  • 末梢神経損傷により脊髄および後根神経節において増加するCB2受容体のCB2作動薬誘発抗アロディニア効果における役割

    下山裕,津田誠,塚本恵子,齊藤秀俊,井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2009.3

    Venue:横浜   Country:Japan  

  • 神経損傷による脊髄アストロサイトの活性化とその神経因性疼痛に対する役割

    辻川智子,津田誠,井上和秀

    第61回日本薬理学会西南部会  2008.11 

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    Event date: 2008.11

    Venue:鳥取   Country:Japan  

  • ミクログリアからのATP 誘発MIP-2 放出のメカニズム

    吉武麻衣,齊藤秀俊,白鳥美穂,津田誠,井上和秀

    第61回日本薬理学会西南部会  2008.11 

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    Event date: 2008.11

    Venue:鳥取   Country:Japan  

  • Platelet-activating factor receptor is required for production of proinflammatory cytokines and neuropathic pain after nerve injury International conference

    Shigeo Hasegawa, Makoto Tsuda and Kazuhide Inoue

    38th Annual Meeting Society for Neuroscience  2008.11 

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    Event date: 2008.11

    Country:United States  

  • Interferon-γ and Lyn tyrosine kinase are required for spinal microglia activation and neuropathic pain after peripheral nerve injury International conference

    2008.11 

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    Event date: 2008.11

    Venue:DC   Country:United States  

  • P2Y6-evoked microglial phagocytosis Invited International conference

    K. Inoue, S. Koizumi, M. Tsuda

    XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Interferon-γ receptors are required for spinal microglia activation and neuropathic pain after peripheral nerve injury International conference

    2008.8 

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    Event date: 2008.8

    Venue:Seoul   Country:Korea, Republic of  

  • フィブロネクチンによるミクログリアP2X4受容体発現増加におけるp53の役割

    豊満笑加,津田誠,米谷美穂,齊藤秀俊,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • 末梢神経損傷によるミクログリアの活性化と神経因性疼痛発症におけるIFN-γの役割

    増田隆博,津田誠,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • 神経因性疼痛における血小板活性化因子受容体の役割

    長谷川茂雄,津田誠,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • ミクログリアからのATP誘発ケモカイン放出におけるNFATの関与

    片岡彩子,齊藤秀俊,古賀結衣,津田誠,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • triply-NOS欠損マウスでの神経因性疼痛の緩和とミクログリアの活性化の抑制

    久保山和哉,津田誠,齊藤秀俊,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • 神経因性疼痛における脊髄ミクログリアP2Y12受容体の関与

    齊藤秀俊,津田誠,井上和秀

    第30回日本疼痛学会 / 福岡ペイン2008  2008.7 

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    Event date: 2008.7

    Venue:福岡   Country:Japan  

  • Role of platelet-activating factor receptor in neuropathic pain International conference

    Shigeo Hasegawa, Makoto Tsuda, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • Involvement of NFAT in chemokine release from microglia induced by ATP International conference

    Ayako Kataoka, Yui Koga, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • Reduced spinal microglia activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases International conference

    Kazuya Kuboyama, Makoto Tsuda, Masato Tsutsui, Yumiko Toyohira, Hidetoshi Tozaki-Saitoh, Hiroaki Shimokawa, Nobuyuki Yanagihara, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • Role of interferon-gamma in spinal microglia activation and neuropathic pain after peripheral nerve injury International conference

    Takahiro Masuda, Makoto Tsuda, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • Role of p53 in microglial P2X4 receptor upregulation by fibronectin International conference

    Emika Toyomitsu, Makoto Tsuda, Miho Kometani, Hidetoshi Saitoh, Kazuhide Inoue

    The 3rd Asian Pain Symposium  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • Interferon-γ receptor regulates spinal microglia activation and neuropathic pain after nerve injury

    井上和秀,増田隆博,津田誠

    日本神経科学会  2008.7 

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    Event date: 2008.7

    Venue:東京   Country:Japan  

  • Lynチロシンキナーゼは神経因性疼痛を引き起こすIFN-γ依存的なミクログリアの活性化に必須である

    増田隆博,津田誠,井上和秀

    第82回日本薬理学会年会  2009.3 

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    Event date: 2008.3 - 2009.3

    Venue:横浜   Country:Japan  

  • 低侵襲的な脊髄後角へのマイクロインジェクション法を用いた細胞種および部位特異的な遺伝子導入

    高露 雄太ら

    第88回日本薬理学会年会  2015.3 

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    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • Astrocytic STAT3 is a crucial factor for reactive astrocytes after nerve injury and neuropathic pain

    Neuro2013  2013.6 

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    Language:Japanese  

    Country:Japan  

  • Chronic pain increases neurokinin 1 receptor mRNA expression in the bed nucleus of stria terminalis: Roles of neurokinin 1 receptor in the anxiety-like behavior

    Neuro2013  2013.6 

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    Language:Japanese  

    Country:Japan  

  • Role of IRF5 in P2X4R upregulation in microglia and neuropathic pain

    Neuro2013  2013.6 

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    Language:Japanese  

    Country:Japan  

  • Transcription factor MafB mediates activation process of spinal microglia that contributes to neuropathic pain development

    Neuro2013  2013.6 

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    Language:Japanese  

    Country:Japan  

  • 神経障害性疼痛におけるアストロサイトSTAT3シグナルの役割

    高露 雄太ら

    生体機能と創薬シンポジウム  2013.8 

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    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 神経障害性疼痛に重要な脊髄ミクログリアの活性化分子メカニズム Invited

    津田 誠

    第28回日本整形外科学会基礎学術集会  2013.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:千葉   Country:Japan  

  • 転写因子IRF5は脊髄ミクログリアP2X4受容体の発現増加を介して神経障害性疼痛発症維持に関与する

    岩本祥佑ら

    第66回日本薬理学会西南部会  2013.11 

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    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 神経障害後の脊髄ミクログリアにおけるMafB発現誘導メカニズムの解析

    小嶋ちなみ ら

    第66回日本薬理学会西南部会  2013.11 

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    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 脊髄後角におけるSTAT3依存的なアストロサイト活性化は慢性的な痒みに必要である

    白鳥美穂ら

    第87回日本薬理学会年会  2014.3 

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    Language:English  

    Venue:仙台   Country:Japan  

  • 末梢神経損傷後に活性化する脊髄ミクログリアへの骨髄由来細胞の寄与

    冨山大輔ら

    第87回日本薬理学会年会  2014.3 

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    Language:Japanese  

    Venue:仙台   Country:Japan  

  • ケモカイン受容体CCR5の神経障害性疼痛への関与

    松下克之ら

    第87回日本薬理学会年会  2014.3 

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    Venue:仙台   Country:Japan  

  • IRF5は神経障害性疼痛を誘発するP2X4受容体発現ミクログリアを直接制御している

    増田 隆博ら

    第87回日本薬理学会年会  2014.3 

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    Language:Japanese  

    Venue:仙台   Country:Japan  

  • Transcriptional regulation of microglial motility by IRF8

    2014.3 

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    Language:Japanese  

    Country:Japan  

  • 転写因子IRF8-IRF5軸は神経障害性疼痛を誘発するP2X4受容体発現ミクログリアを制御している

    増田 隆博ら

    日本薬学会第134年会  2014.3 

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    Language:Japanese  

    Venue:熊本   Country:Japan  

  • 神経障害性疼痛発症における脊髄VNUTの役割

    増田 隆博ら

    第36回日本疼痛学会  2014.6 

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    Language:Japanese  

    Venue:大阪   Country:Japan  

  • ラット脊髄後角表層GABAニューロンへの興奮性シナプス入力に対するP2X3受容体の役割

    古賀啓祐ら

    第36回日本疼痛学会  2014.6 

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    Language:Japanese  

    Venue:大阪   Country:Japan  

  • アデノ随伴ウイルスによる脊髄アストロサイト特異的遺伝子導入法を用いた神経障害性疼痛の解析

    高露 雄太ら

    第130回日本薬理学会関東部会  2014.7 

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    Language:Japanese  

    Venue:東京   Country:Japan  

  • 転写因子IRF5は神経障害性疼痛を誘発するP2X4受容体高発現ミクログリアを制御している

    増田 隆博ら

    第130回日本薬理学会関東部会  2014.7 

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    Language:Japanese  

    Venue:東京   Country:Japan  

  • VNUT contributes to the pathogenesis of neuropathic pain after nerve injury International conference

    Masuda Takahiro et al.

    Purines2014  2014.7 

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    Language:English  

    Country:Germany  

  • Searching for analgesics targeted at P2X4 receptors by screening of well-established drugs International conference

    Tomohiro Yamashita et al.

    Purines2014  2014.7 

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    Language:English  

    Country:Germany  

  • VNUT is required for the pathogenesis of neuropathic pain after nerve injury

    2014.9 

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    Language:Japanese  

    Country:Japan  

  • Duloxetine inhibits P2X4 receptor-mediated calcium responses and suppresses neuropathic pain in rats

    2014.11 

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    Language:Japanese  

    Country:Japan  

  • IRF5 is a crucial determinant for the formation of P2X4R+ reactive microglia driving neuropathic pain International conference

    Masuda Takahiro et al.

    44th Annual Meeting Society for Neuroscience  2014.11 

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    Language:English  

    Country:United States  

  • Spinal astrocytic STAT3 is a crucial factor for reactive astrocytes in neuropathic pain International conference

    Yuta Kohro et al.

    44th Annual Meeting Society for Neuroscience  2014.11 

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    Country:United States  

  • ミクログリアに発現するP2X4受容体を標的とした神経障害性疼痛治療薬の探索に向けたエコファーマの取り組み

    山下 智大ら

    第67回日本薬理学会西南部会  2014.11 

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    Venue:北九州   Country:Japan  

  • 侵害刺激時における脊髄アストロサイトシグナリングのin vivo imaging

    松田烈士ら

    第67回日本薬理学会西南部会  2014.11 

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    Venue:北九州   Country:Japan  

  • 神経障害性疼痛モデルマウスの脊髄内におけるATP放出量の増加とVNUTの役割

    大園由衣ら

    第67回日本薬理学会西南部会  2014.11 

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    Language:Japanese  

    Venue:北九州   Country:Japan  

  • P2X3受容体を介した、脊髄後角抑制性介在ニューロンの興奮性シナプス伝達の調節

    古賀啓祐ら

    第67回日本薬理学会西南部会  2014.11 

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    Venue:北九州   Country:Japan  

  • 痒み発症における一次求心性神経P2X3受容体の関与

    白鳥 美穂ら

    第67回日本薬理学会西南部会  2014.11 

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    Language:Japanese  

    Venue:北九州   Country:Japan  

  • 脊髄後角抑制性介在ニューロンの興奮性シナプス伝達に対するP2X3受容体の役割

    古賀啓祐ら

    第31回日本薬学会九州支部大会  2014.12 

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    Language:Japanese  

    Venue:福岡   Country:Japan  

  • VNUTは神経障害性疼痛発症に重要な役割を果たしている

    増田 隆博ら

    第88回日本薬理学会年会  2015.3 

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    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 神経損傷によるミクログリア活性化と神経因性疼痛におけるIFN-gの役割

    増田隆博,津田誠,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • フィブロネクチンにより誘発される脊髄ミクログリアP2X4受容体発現亢進と神経因性疼痛

    小泉修一,多田薫,津田 誠,国房恵巳子,井上和秀

    第79回日本神経科学大会  2006.7 

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    Country:Japan  

  • 脊髄後角でのニューロンとグリア細胞の相互作用による神経興奮の長期増強

    池田 弘,津田 誠,井上和秀,村瀬一之

    第28回日本疼痛学会  2006.7 

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    Country:Japan  

  • Inhibitory effects of antidepressants on P2X4 receptor: a novel mechanism in neuropathic pain relief

    2006.9 

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    Country:Japan  

  • Activation of spinal microglia in diabetic neuropathic pain rats

    2006.9 

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    Country:Japan  

  • Fibronectin increases expression of P2X4 receptors via ERK activation in microglia

    2006.9 

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    Country:Japan  

  • インターフェロン-γ髄腔内投与は脊髄ミクログリアの活性化および持続性異痛症を引き起こす

    増田隆博,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • 抗うつ薬のP2X4受容体阻害作用:神経因性疼痛寛解作用メカニズムとしての可能性

    永田健一郎,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • 脊髄内ミクログリアにおけるERKの活性化は糖尿病誘発アロディニアに関与する

    上野光,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • フィブロネクチンによるミクログリアP2X4受容体発現増加の分子メカニズム

    豊満笑加,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • 神経因性疼痛におけるATP受容体を介した細胞質型ホスホリパーゼA2の活性化

    長谷川茂雄,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • ラット海馬アストロサイトからのIL-6放出とATP受容体との関連

    藤田拓美,津田誠,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • 神経因性疼痛におけるSrcファミリーチロシンキナーゼLynの役割

    津田誠,増田隆博,手塚徹,北野順子,山本雅,井上和秀

    第80回日本薬理学会年会  2007.3 

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    Country:Japan  

  • ATP receptor-dependent neuropathic pain: a mechanism of the modulation of pain sensation Invited International conference

    K. Inoue, M. Tsuda, H. Saitoh-Tozaki

    7th IBRO World Congress of Neuroscience  2007.7 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Australia  

  • UDP, a novel mediator of microglia phagocytosis Invited

    2007.9 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Involvement of NFAT in chemokine release from microglia induced by ATP

    2007.9 

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    Country:Japan  

  • Minocycline attenuates spinal microglia activation and tactile allodynia caused by interferon-γ

    増田隆博,津田誠,井上和秀

    第50回日本神経化学会大会 / Neuro2007  2007.9 

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    Country:Japan  

  • 神経因性疼痛動物モデルにおける脊髄内ミクログリア増殖様式の解明

    北野順子,津田誠,辻川智子,井上和秀

    第60回日本薬理学会西南部会  2007.11 

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    Venue:宮崎   Country:Japan  

  • UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis International conference

    Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K

    37th Annual Meeting Society for Neuroscience  2007.11 

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    Country:United States  

  • Role of purinergic signaling in IL-6 release from cultured rat hippocampal astrocytes International conference

    Fujita T, Tsuda M, Inoue K

    37th Annual Meeting Society for Neuroscience  2007.11 

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    Country:United States  

  • Intrathecal administration of interferon-γ produces spinal microglia activation and long-lasting tactile allodynia International conference

    2007.11 

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    Venue:San Diego   Country:United States  

  • ミクログリアにおけるP2X4受容体の発現および分布に対するラフトマイクロドメインの関与

    岡綾香、津田誠、齊藤秀俊、井上和秀

    第60回日本薬理学会西南部会  2007.11 

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    Venue:宮崎   Country:Japan  

  • 脊髄におけるアロデニアのメカニズム Invited International conference

    津田誠

    第1回学際的に痛みを考える会-国際フォーラムMusculoskeletal Pain Research-  2007.12 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 「私を食べてシグナル」UDPとミクログリアの貪食作用 Invited

    小泉修一,最上由香里,多田薫,篠崎陽一,大澤圭子,津田誠,高坂新一,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ミクログリアからのATP誘発ケモカイン放出におけるNFAT関与

    片岡彩子,齊藤秀俊,古賀結衣,津田誠,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • 神経因性疼痛発症過程におけるP2Y12受容体の関与

    齊藤秀俊,津田誠,宮田広行,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • 海馬アストログリアおよび神経細胞の酸化ストレス障害に対するATPの防御機能

    藤田拓美,齊藤秀俊,津田誠,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • フィブロネクチンによるミクログリアP2X4受容体発現増加におけるp53の役割

    豊満笑加,津田誠,米谷美穂,齊藤秀俊,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • Triply-NOS欠損マウスでの神経因性疼痛の緩和とミクログリアの活性化の抑制

    久保山和哉,津田誠,筒井正人,豊平由美子,齊藤秀俊,下川宏明,柳原延章,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • 神経因性疼痛発症過程における脊髄フィブロネクチンの役割

    小松孝行,津田誠,山本希美子,安藤譲二,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • フィブロネクチンによるミクログリアP2X4受容体のラフトマイクロドメインへの移行

    岡綾香,津田誠,齊藤秀俊,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

  • 後根神経節の血小板活性化因子受容体は神経因性疼痛に関与する

    長谷川茂雄,津田誠,石井聡,清水孝雄,井上和秀

    第81回日本薬理学会年会  2008.3 

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    Country:Japan  

▼display all

MISC

  • Microglial diversity in neuropathic pain Reviewed

    Trends Neurosci

    2023.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 痛みと痒みの慢性化メカニズムに関する最新知見

    津田誠

    臨床麻酔   2023.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 神経障害性疼痛の寛解および再発に関与する脊髄ミクログリア集団

    津田誠

    化学工業   2023.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ミクログリアと慢性疼痛 ~新しいステージへ~ Reviewed

    津田誠

    実験医学   2022.11

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  • 脊髄後角アストロサイトサブセットを介するノルアドレナリン痛覚伝達制御

    津田誠

    麻酔科プラクティス   2022.11

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  • 慢性疼痛とミクログリア ~新たな方向性~

    津田誠

    麻酔71   2022.11

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  • 中枢神経系の慢性炎症と痛み

    津田誠

    ペインクリニック   2022.5

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  • 神経系マクロファージによる痛覚変調

    津田誠

    実験医学40(5), 108-113, 2022   2022.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Spinal glial cells in itch modulation Reviewed

    Shiatori-Hayashi M, Tsuda M

    Pharmacol Res Perspect   2021.12

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  • 痒みとグリア細胞

    津田誠

    日本医師会雑誌   2021.11

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  • グリア細胞が作り出す神経機能異常による痛みや痒み

    津田誠

    生体の科学   2021.10

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  • アストロサイトと神経障害性疼痛

    津田誠

    実験医学   2021.9

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  • 脊髄後角

    津田誠

    医学のあゆみ   2021.7

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  • 脊髄後角での痛覚信号プロセシングとグリア細胞

    津田誠

    2021.7

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  • かゆみにおけるグリア細胞の働き Reviewed

    津田誠

    実験医学   2021.2

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  • Role of microglia and P2X4 receptors in chronic pain Reviewed

    Kohno K, Tsuda M

    Pain Rep   2021.1

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  • マウス脊髄後角の細胞を標的とした遺伝子導入法 Reviewed

    高露雄太,津田誠

    実験医学別冊「決定版 ウイルスベクターによる遺伝子導入実験ガイド」平井宏和,日置寛之,小林和人/編   2020.11

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  • マウス脊髄後角の細胞を標的とした遺伝子導入法

    高露雄太,津田誠

    実験医学別冊   2020.11

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  • Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions Reviewed

    Shiratori-Hayashi M, Tsuda M

    J Pharmacol Sci   2020.11

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  • グリア細胞による痒みの慢性化機構 Reviewed

    津田誠

    ファルマシア   2020.9

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  • グリア細胞による痛覚の調節機構 Reviewed

    津田誠

    実験医学   2020.2

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  • Microglia-Mediated Regulation of Neuropathic Pain: Molecular and Cellular Mechanisms Reviewed

    Makoto Tsuda

    2019.12

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1248/bpb.b19-00715

  • New approach for investigating neuropathic allodynia by optogenetics

    Tsuda M

    Pain   2019.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1097/j.pain.0000000000001506

  • Microglia-mediated regulation of neuropathic pain Molecular and cellular mechanisms Reviewed

    Makoto Tsuda

    Biological and Pharmaceutical Bulletin   2019.1

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    DOI: 10.1248/bpb.b19-00715

  • Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential.

    Inoue K, Tsuda M

    Nat Rev Neurosci   2018.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1038/nrn.2018.2

  • Microglial regulation of neuropathic pain

    TSUDA MAKOTO et al.

    J Pharmacol Sci   2013.10

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    Language:English  

  • Microglia and intractable chronic pain

    TSUDA MAKOTO, Beggs S, Salter MW, Kazuhide Inoue

    Glia   2013.1

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  • 末梢神経損傷による神経障害性疼痛とグリア

    津田 誠, 齊藤 秀俊, 井上 和秀

    2012.11

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  • Purinergic system, microglia and neuropathic pain.

    Tsuda M, Tozaki-Saitoh H, Inoue K.

    Curr Opin Pharmacol.   2012.2

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  • Microglia and neuropathic pain.

    Inoue K, Tsuda M

    Glia   2009.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 慢性疼痛における細胞外ヌクレオチドとその受容体の役割

    津田 誠,井上和秀

    生化学   2009.10

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  • 神経障害性疼痛におけるATP受容体の役割

    津田誠,齊藤秀俊,井上和秀

    ペインクリニック別冊春号   2009.4

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  • 脊髄ミクログリアを介する神経因性疼痛の発症維持メカニズム

    津田誠

    神経化学,46(4),820-826(2007)   2007.12

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  • Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia.

    Tsuda M, Inoue K, Salter MW.

    Trends Neurosci. 2005 Feb;28(2):101-7.   2005.2

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  • ミクログリアの多様性から読み解く神経障害性疼痛

    津田誠,河野敬太

    日本薬理学雑誌   2024.4

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  • 慢性疼痛とアロスタシス:グリア細胞の役割

    1. 津田誠

    2023.11

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  • 神経障害性疼痛の慢性化を抑止する新たな細胞

    津田誠

    2023.11

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  • 痒みの抑制機構 Reviewed

    白鳥美穂,津田誠

    2023.7

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  • ミクログリア細胞から慢性疼痛のメカニズムを紐解く

    津田誠

    日本心療内科学会誌   2023.6

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  • The Functions and Phenotypes of Microglia in Alzheimer’s Disease Reviewed

    2023.4

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  • 痛みと痒みの慢性化メカニズムに関する最新知見 Reviewed

    津田誠

    臨床麻酔   2023.3

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  • 神経障害性疼痛の新しい分子病態

    津田誠

    2022.2

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  • 神経障害性疼痛のメカニズム

    津田誠

    ペインクリニック   2021.5

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  • グリア細胞とかゆみ

    白鳥美穂,津田誠

    2021.4

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  • 一次求心性神経Aβ線維由来の神経障害性アロディニアに重要な脊髄後角神経サブセット Reviewed

    津田誠

    日本運動器疼痛学会誌   2021.4

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  • Chronic itchとアストロサイト

    津田誠

    臨床免疫・アレルギー科   2021.2

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  • Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors Reviewed

    Inoue K, Tsuda M

    Biochem Pharmacol   2021.1

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  • ノルアドレナリンによる痛覚制御機構:グリア細胞を介する新しいメカニズム

    津田誠

    日本生物学的精神医学会誌   2021.1

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  • 脊髄におけるmicrogliaによる中枢感作形成

    津田誠

    ペインクリニック   2020.12

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  • ミクログリアと神経障害性疼痛 Reviewed

    津田誠

    医学のあゆみ   2020.6

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  • Microglia-neuron interactions in the models of neuropathic pain Reviewed

    Hidetoshi Tozaki-Saitoh, Makoto Tsuda

    Biochemical Pharmacology   2019.11

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    DOI: 10.1016/j.bcp.2019.08.016

  • 痛みと痒みの慢性化とグリア細胞 Reviewed

    津田誠

    実験医学   2019.10

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  • 神経障害による痛み Reviewed

    津田誠

    あたらしい眼科   2019.6

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  • ニューロパシックペインの発症・維持の機序について Reviewed

    津田誠

    ペインクリニック   2019.5

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  • 感覚情報処理における脊髄グリア細胞の役割

    津田誠

    日本顎関節学会誌   2019.4

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  • 脊髄後角での基礎研究

    津田誠

    ペインクリニック   2019.1

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  • 脊髄後角の神経・グリア相互作用が作り出す慢性掻痒

    津田誠

    2018.12

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  • 神経障害性疼痛と神経系マクロファージ

    津田誠

    実験医学   2018.9

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  • 痒みのメカニズム:痒みの慢性化と脊髄後角アストロサイト

    津田誠

    神経内科   2018.7

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  • 目の前のチャンスに気付けるか

    津田誠

    日本薬理学雑誌   2018.7

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  • 痛みと中枢神経系免疫細胞

    津田誠

    炎症と免疫   2018.7

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    Language:Japanese  

  • 脊髄後角アストロサイトと掻痒

    津田誠

    臨床免疫・アレルギー科   2018.4

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  • 痛みが慢性化する神経メカニズム:特にニューロン-グリア連関の関与について

    津田誠

    ペインクリニック   2018.4

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  • Astrocytes in the spinal dorsal horn and chronic itch.

    Tsuda M

    2018.2

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    DOI: 10.1007/s12264-017-0129-y

  • 5. Nishimura A, Sunggip C, Oda S, Numaga-Tomita T, Tsuda M, Nishida M

    Nishimura A, Sunggip C, Oda S, Numaga-Tomita T, Tsuda M, Nishida M

    Pharmacol Ther   2017.12

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    DOI: 10.1016/j.pharmthera.2017.06.010

  • 慢性化したかゆみのメカニズム

    白鳥美穂、津田誠

    2017.11

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  • P2 receptors, microglial cytokines and chemokines, and neuropathic pain

    TSUDA MAKOTO

    J Neurosci Res 95(6): 1319-1329   2017.6

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  • Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.

    Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M, Nishida M

    Pharmacol Res   2017.6

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    DOI: 10.1016/j.phrs.2017.03.013

  • Spinal dorsal horn astrocytes: new players in chronic itch

    TSUDA MAKOTO

    Allergol Int 66: 31-35   2017.1

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  • 脊髄では何がおきているのか? : 神経障害性疼痛の脊髄後角におけるメカニズム

    津田 誠

    医学のあゆみ 260(2), 141-143   2017.1

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  • 慢性炎症と痒み

    津田 誠

    最新医学71, 114-118   2016.11

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  • ATP受容体

    津田 誠

    2016.11

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  • 慢性的なかゆみの新しい神経系メカニズム

    津田 誠, 白鳥 美穂

    生化学 88(5), 654-656   2016.10

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  • 脊髄後角アストロサイトと痒み

    津田 誠

    アレルギー・免疫23(9), 1200-1205   2016.9

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  • 神経障害性疼痛の発症維持メカニズム

    津田 誠

    ファルマシア   2016.8

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  • ミクログリアと神経障害性疼痛

    増田隆博ら

    細胞 48(8), 357-360   2016.8

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  • 慢性痛とグリア細胞

    齊藤 秀俊ら

    2016.8

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  • P2Y受容体(ATP受容体)関連分子をターゲットとした臨床応用

    齊藤 秀俊ら

    2016.7

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  • P2Y 受容体(ATP 受容体)の生理的および薬理的作用

    齊藤 秀俊ら

    2016.6

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  • 慢性的な痒みにおけるSTAT3依存的な活性化アストロサイトの役割

    白鳥 美穂, 津田 誠

    臨床免疫・アレルギー科65(5), 458-462   2016.5

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  • Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

    TSUDA MAKOTO et al.

    Neuropharmacology, 104:76-81   2016.5

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  • Transcriptional regulation in microglia and neuropathic pain

    Masuda T et al.

    Pain Manag. 6(2): 91-94   2016.4

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  • ミクログリアの活性化と形質を制御するIRF転写因子ファミリー

    増田隆博ら

    生化学   2016.2

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  • 脊髄後角におけるSTAT3依存的なアストロサイト活性化は痒みの慢性化に必要である

    白鳥 美穂ら

    実験医学   2016.1

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  • 痒みの伝達とその慢性化の神経系メカニズム

    津田 誠

    感染 炎症 免疫   2016.1

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  • アトピー性皮膚炎に伴う慢性的な痒みと脊髄後角アストロサイト

    津田 誠

    生体の科学   2015.12

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  • 痛覚

    津田 誠

    2015.5

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  • P2Y 受容体(ATP 受容体)の種類

    齊藤 秀俊ら

    2015.5

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  • 脊髄内痛み物質同定のためのマイルストーン研究

    津田 誠

    2015.3

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  • グリア細胞から見た神経障害性疼痛メカニズム

    津田 誠

    日本神経精神薬理学雑誌   2015.2

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  • 神経障害性疼痛

    津田 誠, 松下克之, 井上 和秀

    日本薬理学雑誌   2014.4

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  • 慢性疼痛におけるグリア細胞の関与と治療応用への可能性

    津田 誠, 井上 和秀

    臨床整形外科   2013.12

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  • 慢性疼痛におけるグリア細胞の関与と治療応用への可能性

    津田 誠ら

    臨床整形外科   2013.10

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  • Microglial regulation of neuropathic pain

    TSUDA MAKOTO, Masuda Takahiro, Hidetoshi Saitoh, Kazuhide Inoue

    J Pharmacol Sci   2013.2

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  • 慢性難治性疼痛とミクログリア活性化

    井上 和秀, 津田 誠, 齊藤 秀俊, 増田 隆博

    炎症と免疫   2012.11

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  • P2X4 receptors of microglia in neuropathic pain

    Kazuhide Inoue, TSUDA MAKOTO

    CNS Neurol Disord Drug Targets   2012.9

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  • Purinergic systems, neuropathic pain and the role of microglia.

    Inoue K, Tsuda M.

    Exp Neurol.   2012.4

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  • Role of purinergic receptors in CNS function and neuroprotection.

    Tozaki-Saitoh H, Tsuda M, Inoue K

    Adv Pharmacol   2011.9

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  • 痛みの分子メカニズムにおける最近の話題

    津田 誠,井上和秀

    化学と生物   2011.8

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  • Platelet-activating factor and pain.

    Tsuda M, Tozaki-Saitoh H, Inoue K

    Biol Pharm Bull.   2011.7

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  • P2Y6-evoked microglial phagocytosis

    Inoue K, Koizumi S, Kataoka A, Tozaki-Saitoh H, Tsuda M

    Int Rev Neurobiol   2010.7

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  • Pain and purinergic signaling.

    Tsuda M, Tozaki-Saitoh H, Inoue K

    Brain Res Rev   2010.5

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  • 痛みの慢性化と脊髄グリア細胞の役割

    津田誠,井上和秀

    臨床麻酔   2010.3

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  • 高速原子間力顕微鏡を用いた受容体の1分子イメージング

    篠崎陽一、住友弘二、津田 誠、小泉修一、井上和秀、鳥光慶一

    日本薬理学雑誌   2009.8

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  • ATP受容体

    井上和秀、津田誠、斎藤秀俊

    2009.5

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  • 痛みとATP受容体

    井上和秀,津田誠,斎藤秀俊

    ペインクリニック   2009.3

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  • 鎮痛薬開発の現状とこれから

    津田 誠,井上和秀

    月刊薬事   2008.11

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  • 神経障害性疼痛におけるATP受容体の役割

    津田誠,齊藤秀俊,井上和秀

    ペインクリニック,29(2),164-169(2008)   2008.2

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  • The role of nucleotides in the neuron–glia communication responsible for the brain functions

    J Neurochem 102: 1447–1458 (2007)   2007.9

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  • ATP受容体を介する慢性疼痛発症機構

    津田誠,井上和秀

    医学のあゆみ 222,892-893 (2007)   2007.9

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  • 神経因性疼痛と脊髄ミクログリアのATP受容体

    津田誠,井上和秀:

    BRAIN and NERVE-神経研究の進歩,59,953-959(2007)   2007.9

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  • Modification of neuropathic pain sensation through microglial ATP receptors

    Kazuhide Inoue, Makoto Tsuda, Hidetoshi Tozaki-Saitoh

    Purinergic Signalling, 3: 311-316 (2007)   2007.9

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  • P2Y12受容体を介するミクログリア細胞運動

    津田誠

    日本薬理学雑誌129, 389 (2007)   2007.5

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  • 脊髄ミクログリアのATP受容体を介する新しい神経因性疼痛メカニズム

    津田誠

    日本薬理学雑誌129, 349-353 (2007)   2007.5

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  • 神経およびグリア細胞培養系を利用した疼痛基礎研究

    津田誠,長谷川茂雄,小泉修一,井上和秀

    ペインクリニック, 27, 1597-1604 (2006)   2006.12

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  • 細胞外ATPを介した表皮ケラチノサイトー知覚神経間コミュニケーション;痛み伝達への関与

    小泉修一,藤下加代子,津田誠,井上和秀

    Pain Research, 21, 133-139 (2006)   2006.8

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  • 神経因性疼痛におけるミクログリア発現分子の役割

    津田誠,井上和秀

    日本神経精神薬理学雑誌 26, 57-61(2006)   2006.2

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  • 脊髄ミクログリア細胞の痛みへの役割

    津田誠,井上和秀

    Pain Research, 21, 1-4 (2006)   2006.2

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  • 神経因性疼痛とATP受容体

    井上和秀,津田誠

    日薬理誌, 127, 14-17 (2006)   2006.1

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  • ATP receptors in pain sensation: Involvement of spinal microglia and P2X4 receptors.

    Inoue K, Tsuda M, Koizumi S.

    Purinergic Signalling, 1, 95-100 (2005).   2005.4

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  • ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4.

    Inoue K, Tsuda M, Koizumi S.

    J Pharmacol Sci. 2004 Feb;94(2):112-4.   2004.2

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  • The functions of ATP receptors in the synaptic transmission in the hippocampus.

    Inoue K, Koizumi S, Ueno S, Kita A, Tsuda M.

    Prog Brain Res. 1999;120:193-206.   1999.11

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  • Contribution of glutamate receptors to benzodiazepine withdrawal signs.

    Tsuda M, Shimizu N, Suzuki T.

    Jpn J Pharmacol. 1999 Sep;81(1):1-6.   1999.9

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本薬理学会

  • 日本神経精神薬理学会

  • 日本疼痛学会

  • 日本神経化学会

  • Society for Neuroscience

  • 日本運動器疼痛学会

  • 日本薬学会

  • 日本神経科学学会

  • 日本生化学会

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Committee Memberships

  • Executive   Domestic

    2023.3 - 2024.6   

  • Executive   Domestic

    2020.4 - 2024.3   

  • Steering committee member   Domestic

    2018.4 - Present   

  • Steering committee member   Domestic

    2018.4 - Present   

  • 日本運動器疼痛研究会   編集委員会委員   Domestic

    2018.4 - Present   

  • 日本運動器疼痛研究会   編集委員会委員   Domestic

    2018.4 - Present   

  • Steering committee member   Domestic

    2018.4 - 2020.3   

  • 日本薬理学会   財務委員   Domestic

    2018.4 - 2020.3   

  • Steering committee member   Domestic

    2017.9 - 2021.3   

  • 日本神経化学会   優秀賞・奨励賞選考委員会委員   Domestic

    2017.9 - 2021.3   

  • Steering committee member   Domestic

    2016.10 - 2018.10   

  • 日本神経精神薬理学会   先端研究推進基盤構築タスクフォース委員   Domestic

    2016.10 - 2018.10   

  • Steering committee member   Domestic

    2016.4 - 2018.3   

  • Steering committee member   Domestic

    2016.4 - 2018.3   

  • 日本薬理学会   編集委員会委員   Domestic

    2016.4 - 2018.3   

  • 日本薬理学会   賞等選考委員会委員   Domestic

    2016.4 - 2018.3   

  • Executive   Domestic

    2014.6 - 2023.5   

  • Councilor   Domestic

    2012.10 - Present   

  • 日本薬理学会   代議員   Domestic

    2012.4 - 2013.3   

  • Councilor   Domestic

    2010.7 - Present   

  • Councilor   Domestic

    2008.12 - Present   

  • Councilor   Domestic

    2008.9 - Present   

  • 日本薬理学会   代議員   Domestic

    2006.10 - 2008.9   

  • Councilor   Domestic

    2005.4 - Present   

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Academic Activities

  • プログラム委員

    第68回日本神経化学会大会  ( 名古屋 ) 2025.9

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  • 実行委員長,プログラム委員

    ( 福岡 ) 2024.7

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    Type:Competition, symposium, etc. 

  • 企画委員

    第51回日本毒性学会学術年会  ( 福岡 ) 2024.7

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第96回日本生化学会大会  ( 福岡 ) 2023.10 - 2023.11

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第46回日本神経科学大会  ( 仙台 ) 2023.8

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    Type:Competition, symposium, etc. 

  • Pain Research International contribution

    2023.4 - Present

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    Type:Academic society, research group, etc. 

  • 特別講演座長

    日本薬学会第143年会  ( 札幌 ) 2023.3

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  • シンポジウム座長

    日本生理学会第100回記念大会  ( 京都 ) 2023.3

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  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:16

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:38

  • 一般演題座長

    第44回日本疼痛学会  ( 岐阜 ) 2022.12

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第96回日本薬理学会年会  ( 横浜 ) 2022.11 - 2022.12

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    Type:Competition, symposium, etc. 

  • ポスター演題座長

    第96回日本薬理学会年会  ( 横浜 ) 2022.11 - 2022.12

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    Type:Competition, symposium, etc. 

  • 一般演題座長

    第75回日本薬理学会西南部会  ( 高知 ) 2022.10

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    Type:Competition, symposium, etc. 

  • プログラム委員

    NEURO2022(第45 回日本神経科学大会・第65 回日本神経化学会大会・第32 回日本神経回路学会大会)  ( 沖縄 ) 2022.6 - 2022.7

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    Type:Competition, symposium, etc. 

  • 一般演題座長

    ( 沖縄 ) 2022.5 - 2022.6

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    Type:Competition, symposium, etc. 

  • 特別企画シンポジウム座長

    第15回日本緩和医療薬学会年会  ( 熊本 ) 2022.5

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  • AMED-CREST, PRIME「老化」領域 アドバイザー

    Role(s): Review, evaluation

    2022.4 - Present

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    Type:Scientific advice/Review 

  • シンポジウムオーガナイザー&座長

    第95回日本薬理学会年会  ( 福岡*ハイブリッド ) 2022.3

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    Type:Competition, symposium, etc. 

  • 組織委員

    第95回日本薬理学会年会  ( 福岡 ) 2022.3

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  • 組織委員

    第95回日本薬理学会年会  ( 福岡*ハイブリッド ) 2022.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:23

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:27

  • 一般演題座長

    第43回日本疼痛学会  ( 愛知*オンライン ) 2021.12

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー&座長

    第43回日本疼痛学会  ( 愛知*オンライン ) 2021.11

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー&座長

    第94回日本生化学会  ( 横浜*オンライン ) 2021.11

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    Type:Competition, symposium, etc. 

  • 主催

    第5回感覚フロンティア研究会シンポジウム  ( オンライン ) 2021.10

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー&座長

    第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会  ( 名古屋 *WEB開催 ) 2021.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:30

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:37

  • プログラム委員

    第42回日本疼痛学会  ( 東京 ) 2020.12

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    Type:Competition, symposium, etc. 

  • Frontiers in Pain Research International contribution

    2020.10 - Present

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    Type:Academic society, research group, etc. 

  • Frontiers in Molecular Neuroscience International contribution

    2020.6 - Present

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    Type:Academic society, research group, etc. 

  • プログラム委員

    第14回日本緩和医療薬学会年会  ( 岡山 ) 2020.5

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    Type:Competition, symposium, etc. 

  • AMED-CREST, PRIME「適応・修復」領域 科学技術調査員(外部査読委員)

    Role(s): Review, evaluation

    2020.5 - 2020.7

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    Type:Scientific advice/Review 

  • プログラム委員

    第93回日本薬理学会年会  ( 横浜 ) 2020.3

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    Type:Competition, symposium, etc. 

  • Neuroscience Research International contribution

    2020.1 - 2022.12

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:49

    Number of peer-reviewed articles in Japanese journals:2

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:8

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2019.12 - 2020.11

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    Type:Scientific advice/Review 

  • プログラム委員

    第6回アジア神経精神薬理学会大会(AsCNP2019)  ( 福岡 ) 2019.10

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    Type:Competition, symposium, etc. 

  • Organizing Committee

    ( Japan ) 2019.10

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • プログラム委員

    第42回日本神経科学大会・第62回日本神経化学会大会合同大会(Neuro2019)  ( 新潟 ) 2019.7

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    Type:Competition, symposium, etc. 

  • プログラム・査読委員

    第41回日本疼痛学会  ( 名古屋 ) 2019.7

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第13回日本緩和医療薬学会年会  ( 幕張 ) 2019.5 - 2019.6

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    Type:Competition, symposium, etc. 

  • AMED-CREST, PRIME「適応・修復」領域 科学技術調査員(外部査読委員)

    Role(s): Review, evaluation

    2019.5 - 2019.7

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    Type:Scientific advice/Review 

  • シンポジウムオーガナイザー

    日本薬学会第139年会  ( 千葉 ) 2019.3

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    第92回日本薬理学会年会  ( 大阪 ) 2019.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:32

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of International Conference Number of peer-reviewed papers:27

    Proceedings of domestic conference Number of peer-reviewed papers:10

  • 一般演題座長

    第11回日本運動器疼痛学会  ( 滋賀 ) 2018.12

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2018.12 - 2019.11

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    Type:Scientific advice/Review 

  • 一般演題座長

    第71回日本薬理学会西南部会  ( 福岡 ) 2018.11

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    Type:Competition, symposium, etc. 

  • 実行委員

    第71回日本薬理学会西南部会  ( 福岡 ) 2018.11

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    Type:Competition, symposium, etc. 

  • カナダNSERCグラント審査員

    Role(s): Review, evaluation

    カナダNSERC  2018.11

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    Type:Scientific advice/Review 

  • シンポジウムオーガナイザー

    第61回日本神経化学会  ( 神戸 ) 2018.9

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    生体機能と創薬シンポジウム2018  ( 福岡 ) 2018.8

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    Type:Competition, symposium, etc. 

  • Oral session座長 International contribution

    18th World Congress of Basic and Clinical Pharmacology (WCP2018)  ( 京都 ) 2018.7

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    Type:Competition, symposium, etc. 

  • 教育講演座長

    第40回日本疼痛学会  ( 長崎 ) 2018.6

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第40回日本疼痛学会  ( 長崎 ) 2018.6

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    Type:Competition, symposium, etc. 

  • AMED-CREST, PRIME「適応・修復」領域 科学技術調査員(外部査読委員)

    Role(s): Review, evaluation

    2018.5 - 2018.8

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    Type:Scientific advice/Review 

  • Neuroscience Bulletin International contribution

    2018.1 - 2020.12

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:33

    Number of peer-reviewed articles in Japanese journals:2

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:53

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2017.12 - 2018.11

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    Type:Scientific advice/Review 

  • 公益財団法人 国際科学技術財団 研究助成選考委員

    Role(s): Review, evaluation

    公益財団法人 国際科学技術財団  2017.12 - 2018.4

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    Type:Scientific advice/Review 

  • 座長

    第10回日本運動器疼痛学会  2017.11

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    Type:Competition, symposium, etc. 

  • カナダNSERCグラント審査員

    Role(s): Review, evaluation

    2017.11 - 2018.1

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    Type:Scientific advice/Review 

  • プログラム委員

    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会  ( 札幌 ) 2017.9

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会  ( 札幌 ) 2017.9

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第60回神経化学会大会  ( 仙台 ) 2017.9

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第60回神経化学会大会  ( 仙台 ) 2017.9

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    Type:Competition, symposium, etc. 

  • 座長

    第60回神経化学会大会  2017.9

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    Type:Competition, symposium, etc. 

  • 実行委員

    生体機能と創薬シンポジウム2017  ( 京都 ) 2017.8

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    生体機能と創薬シンポジウム2017  ( 京都 ) 2017.7

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    Type:Competition, symposium, etc. 

  • 国際事業委員会書面評価委員

    Role(s): Review, evaluation

    日本学術振興会  2017.4 - 2018.3

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    Type:Scientific advice/Review 

  • 組織委員

    第90回日本薬理学会年会  ( 長崎 ) 2017.3

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    Type:Competition, symposium, etc. 

  • 組織委員

    第90回日本薬理学会年会  ( 長崎 ) 2017.3

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    第90回日本薬理学会年会  ( 長崎 ) 2017.3

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    Type:Competition, symposium, etc. 

  • シンポジウムコメンテーター

    第90回日本薬理学会年会  ( 長崎 ) 2017.3

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    Type:Competition, symposium, etc. 

  • 主催

    平成28年度 岡崎生理研研究会「痛みの理解を目指した先端的アプローチ」  ( 岡崎 ) 2017.1

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • 主催

    平成28年度 岡崎生理研研究会  ( 岡崎 ) 2017.1

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:43

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:17

  • 座長(Chairmanship)

    第69回日本薬理学会西南部会  ( 愛媛 ) 2016.11

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    Type:Competition, symposium, etc. 

  • 大学設置・学校法人審議会(大学設置分科会)専門委員

    Role(s): Review, evaluation

    文部科学省  2016.11 - 2017.10

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第60回日本神経化学会大会  ( 福岡 ) 2016.9

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第46回日本神経精神薬理学会  ( ソウル ) 2016.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第38回日本疼痛学会  ( 札幌 ) 2016.6 - 2016.4

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    Type:Competition, symposium, etc. 

  • J Pharmacol Sci International contribution

    2016.4 - 2018.3

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    Type:Academic society, research group, etc. 

  • 座長(Chairmanship)

    第89回日本薬理学会年会  ( 横浜 ) 2016.3

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    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザー

    第89回日本薬理学会年会  ( 横浜 ) 2016.3

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    Type:Competition, symposium, etc. 

  • 主催

    平成27年度 岡崎生理研研究会「痛みの理解を目指した先端的アプローチ」  ( 岡崎 ) 2015.12

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2015.12 - 2016.11

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    Type:Scientific advice/Review 

  • プログラム委員

    第45回日本神経精神薬理学会  ( 東京 ) 2015.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第58回神経化学会大会  ( さいたま ) 2015.9 - 2016.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第38回日本神経科学大会  ( 神戸 ) 2015.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本薬学会第135年会  ( 神戸 ) 2015.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第31回日本薬学会九州支部大会  ( 福岡 ) 2014.12

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2014.12 - 2015.11

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第67回日本薬理学会西南部会  ( 北九州 ) 2014.11

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    Type:Competition, symposium, etc. 

  • グラント審査委員

    Role(s): Review, evaluation

    2014.11 - 2015.11

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    Type:Scientific advice/Review 

  • プログラム委員

    第8回日本緩和医療薬学会年会  ( 愛媛 ) 2014.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第130回日本薬理学会関東部会  ( 東京 ) 2014.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    日本学術振興会二国間(日独)交流事業研究セミナー  ( ミュンヘン ) 2014.6 - 2014.7

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    Type:Competition, symposium, etc. 

  • オーガナイザー

    日本薬学会第134年会  ( 熊本 ) 2014.3

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    Type:Competition, symposium, etc. 

  • オーガナイザー

    第87回日本薬理学会年会  ( 仙台 ) 2014.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2014.3

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    Type:Competition, symposium, etc. 

  • 主催

    第4回福岡薬理・生理研究会  ( 福岡 ) 2013.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第66回日本薬理学会西南部会  ( 福岡 ) 2013.11

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    Type:Competition, symposium, etc. 

  • 実行委員

    生体機能と創薬シンポジウム  ( 福岡 ) 2013.8

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    Type:Competition, symposium, etc. 

  • プログラム委員

    ( 京都 ) 2013.6 - 2014.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    ( 京都 ) 2013.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第86回日本薬理学会年会  ( 福岡 ) 2013.3

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2012.12 - 2013.11

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第5回運動器疼痛学会  ( 東京 ) 2012.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第11回次世代を担う若手ファーマバイオフォーラム  ( 福岡 ) 2012.9

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    Type:Competition, symposium, etc. 

  • 不明

    日本麻酔科学会第59回学術集会  ( 神戸 ) 2012.6

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    Type:Competition, symposium, etc. 

  • 事務局長 International contribution

    2012.5 - 2012.6

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    Type:Competition, symposium, etc. 

    Number of participants:330

  • カナダNSERCグラント審査員

    Role(s): Review, evaluation

    2011.11 - 2012.1

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第84回日本薬理学会年会  ( 横浜 ) 2011.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第85回日本薬理学会年会  ( 京都 ) 2011.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第21回神経行動薬理若手研究者の集い  ( 京都 ) 2011.3

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2010.11

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    Type:Scientific advice/Review 

  • 実行委員

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  ( 神戸 ) 2010.9

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    Type:Competition, symposium, etc. 

    Number of participants:4,000

  • 座長(Chairmanship)

    Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)  ( 神戸 ) 2010.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第83回日本薬理学会年会  ( 大阪 ) 2010.3

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会・専門委員

    Role(s): Review, evaluation

    日本学術振興会  2009.11

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    Type:Scientific advice/Review 

  • 実行委員 International contribution

    ( 福岡 ) 2009.7 - 2010.7

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長(Chairmanship)

    第18回神経行動薬理若手研究者の集い  ( 横浜 ) 2009.3

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  • 座長(Chairmanship)

    第82回日本薬理学会年会  ( 横浜 ) 2009.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    トランスポーターワークショップ IN 福岡  ( 福岡 ) 2008.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    生理学研究所研究会『病態と細胞外プリン-治療標的としての可能性を探る』  ( 岡崎 ) 2008.9

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    Type:Competition, symposium, etc. 

  • プログラム委員

    第30回日本疼痛学会 / 福岡ペイン2008  ( 福岡 ) 2008.7 - Present

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    Type:Competition, symposium, etc. 

    Number of participants:2,500

  • 座長(Chairmanship)

    第80回日本薬理学会年会  2007.3 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    平成18年度生理研研究会「痛みの分子メカニズムと治療戦略」  2006.11 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    平成18年度生理学研究所研究会「Neuro-glio-vascular interaction におけるプリン作動性シグナリングの病態生理的機能」  2006.9 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第40回日本ペインクリニック学会  2006.7 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    2005.7 - Present

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    Type:Competition, symposium, etc. 

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Other

  • 学術論文「Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch」がNature Commun誌(IF:17.694)に掲載された。

    2022.5

  • 学術論文「A spinal microglia population involved in remitting and relapsing neuropathic pain」がScience誌(IF:47.728)に掲載された。

    2022.4

  • 学術論文「Astrocytic STAT3 activation and chronic itch require IP3R1/TRPC-dependent Ca2+ signals in mice」がJ Allergy Clin Immunol 誌(IF:10.793)に掲載された。

    2021.4

  • 学術論文「A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior」がPNAS誌(IF:11.205)に掲載された。

    2021.1

  • 学術論文「Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity」がNature Neuroscience誌(IF:20.071)に掲載された。

    2020.10

  • 学術論文「Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor」がJ Allergy Clin Immunol 誌(IF:14.11)に掲載された。

    2020.1

  • 学術論文「Role of P2X3 receptors in scratching behavior in mouse models」がJ Allergy Clin Immunol 誌に掲載された。

    2019.1

  • 神経障害性疼痛とミクログリアに関する総説「Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential」がNature Reviews Neuroscience誌に掲載された。

    2018.3

  • 学術論文「STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch」がNature Medicine誌に掲載された。

    2015.7

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Research Projects

  • 神経障害性疼痛に対する生体レジリエンス機構の解明と診断・治療への応用

    Grant number:24H00067  2024 - 2028

    日本学術振興会  科学研究費助成事業  基盤研究(S)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 生体ストレスによる痛み発生・変調機構の解明と慢性疼痛診断治療技術の開発

    2023 - 2028

    AMED-CREST

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    Authorship:Principal investigator  Grant type:Contract research

  • グリア多様性を軸にした介入法による感覚など全身機能の変容

    Grant number:JP20H05900  2020 - 2024

    日本学術振興会・文部科学省  科学研究費助成事業  学術変革領域研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 神経障害性疼痛に直結する神経回路動作異常メカニズムの解明と創薬への応用

    Grant number:19H05658  2019 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(S)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 神経障害性アロディニアに直結する神経回路機能異常の解明(*基盤S採択のため中止)

    Grant number:19H01059  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 痒みの情報伝達における新しい脊髄後角神経回路の特定

    Grant number:19K22500  2019 - 2020

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • メカノ作動性分子を標的としたドラッグリポジショニング研究

    2018.4 - 2019.4

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 第47回内藤記念特定研究助成金

    2018

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    Grant type:Donation

  • メカノ作動性分子を標的としたドラッグリポジショニング研究

    2017.4 - 2018.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • ATP受容体によるインスリン開口分泌調整機構の解明

    2017.4 - 2018.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 慢性の痒みと痛みのメカニズムと治療法の開発に関する研究

    2016.6 - 2018.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • メカノ作動性分子を標的としたドラッグリポジショニング研究

    2016.4 - 2017.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 慢性疼痛における糖脂質シグナルの作動機序解明と創薬に向けた研究

    2016 - 2020

    AMED 革新的先端研究開発支援事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 皮膚バリアに影響する一次求心性神経由来シグナル分子の特定

    2016 - 2018

    AMED 免疫アレルギー疾患等実用化研究事業(免疫アレルギー疾患実用化研究分野)

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    Authorship:Principal investigat