修士論文発表会・優秀研究論文賞

2010.3   東京大学大学院新領域創成科学研究科メディカルゲノム専攻  

英語論文発表会・最優秀賞

2008.12   東京大学大学院新領域創成科学研究科メディカルゲノム専攻  

On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q Reviewed

Saeko Yanaka, Rina Yogo, Hiroki Watanabe, Yuki Taniguchi, Tadashi Satoh, Naoko Komura, Hiromune Ando, Hirokazu Yagi, Nobuhiro Yuki, Takayuki Uchihashi, Koichi Kato

International Journal of Molecular Sciences   21 ( 1 )   147 - 147   2019.12

The Fab portion of immunoglobulin G contributes to its binding to Fcγ receptor III Reviewed

9 ( 1 )   11957   2019.12

Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations Reviewed

Saeko Yanaka, Rina Yogo, Rintaro Inoue, Masaaki Sugiyama, Satoru G. Itoh, Hisashi Okumura, Yohei Miyanoiri, Hirokazu Yagi, Tadashi Satoh, Takumi Yamaguchi, Koichi Kato

Antibodies   8 ( 3 )   2019.7

Stable isotope labeling approaches for NMR characterization of glycoproteins using eukaryotic expression systems. Reviewed

Yanaka S, Yagi H, Yogo R, Yagi-Utsumi M, Kato K

Journal of biomolecular NMR   71 ( 3 )   193 - 202   2018.2

NMR Detection of Semi-Specific Antibody Interactions in Serum Environments. Reviewed

Yanaka S, Yamazaki T, Yogo R, Noda M, Uchiyama S, Yagi H, Kato K

Molecules (Basel, Switzerland)   22 ( 10 )   2017.9

Identification of potential C1-binding sites in the immunoglobulin CL domains

Saeko Yanaka, Atsuji Kodama, Shigetaka Nishiguchi, Rina Hiramine, Jiana Shen, Pornthip Boonsri, Duckyong Sung, Yukiko Isono, Hirokazu Yagi, Yohei Miyanoiri, Takayuki Uchihashi, Koichi Kato

International Immunology   2024.4

Quantitative Analysis of Therapeutic Antibody Interactions with Fcγ Receptors Using High-Speed Atomic Force Microscopy.

47 ( 1 )   334 - 338   2024.1

Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains

Methanee Hiranyakorn, Maho Yagi-Utsumi, Saeko Yanaka, Naoya Ohtsuka, Norie Momiyama, Tadashi Satoh, Koichi Kato

International Journal of Molecular Sciences   24 ( 7 )   6075   2023.3

The B Domain of Protein A Retains Residual Structures in 6 M Guanidinium Chloride as Revealed by Hydrogen/Deuterium-Exchange NMR Spectroscopy. International journal

Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kunihiro Kuwajima

Protein science : a publication of the Protein Society   e4569   2023.1

The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa

Yuki Yamaguchi, Natsumi Wakaizumi, Mine Irisa, Takahiro Maruno, Mari Shimada, Koya Shintani, Haruka Nishiumi, Rina Yogo, Saeko Yanaka, Daisuke Higo, Tetsuo Torisu, Koichi Kato, Susumu Uchiyama

mAbs   14 ( 1 )   2022.12

Four-dimensional Structures and Molecular Designs of Glycans

Saeko Yanaka

Trends in Glycoscience and Glycotechnology   34 ( 201 )   E85 - E90   2022.9

DMSO-Quenched H/D-Exchange 2D NMR Spectroscopy and Its Applications in Protein Science. International journal

Kunihiro Kuwajima, Maho Yagi-Utsumi, Saeko Yanaka, Koichi Kato

Molecules (Basel, Switzerland)   27 ( 12 )   2022.6

Fungal β‐Mannosyloxymannitol Glycolipids and Their Analogues: Synthesis and Mincle‐Mediated Signaling Activity

2022 ( 20 )   2022.5

Efficient Visible/NIR Light-driven Uncaging of Hydroxylated Thiazole Orange-based Caged Compounds in Aqueous Media

Ryu Hashimoto, Masafumi Minoshima, Souhei Sakata, Fumihito Ono, Hirokazu Ishii, Yuki Watakabe, Tomomi Nemoto, Saeko Yanaka, Koichi Kato, Kazuya Kikuchi

Chemical Science   13 ( 25 )   7462 - 7467   2022.2

Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase. International journal

Siriluk Ratanabunyong, Supaphorn Seetaha, Supa Hannongbua, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Atchara Paemanee, Kiattawee Choowongkomon

Molecules (Basel, Switzerland)   27 ( 1 )   2022.1

Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade. International journal

Maho Yagi-Utsumi, Kazuhiro Aoki, Hiroki Watanabe, Chihong Song, Seiji Nishimura, Tadashi Satoh, Saeko Yanaka, Christian Ganser, Sae Tanaka, Vincent Schnapka, Ean Wai Goh, Yuji Furutani, Kazuyoshi Murata, Takayuki Uchihashi, Kazuharu Arakawa, Koichi Kato

Scientific reports   11 ( 1 )   21328 - 21328   2021.11

Tardigrade Secretory-Abundant Heat-Soluble Protein Has a Flexible β-Barrel Structure in Solution and Keeps This Structure in Dehydration. International journal

125 ( 32 )   9145 - 9154   2021.8

Structural and Functional Roles of the N-Glycans in Therapeutic Antibodies

Hirokazu Yagi, Saeko Yanaka, Koichi Kato

Comprehensive Glycoscience   534 - 542   2021.6

Investigation of RT1t49 aptamer binding to human immunodeficiency virus 1 reverse transcriptase

{Supa Hannongbua}

JOURNAL OF CURRENT SCIENCE AND TECHNOLOGY   11 ( 1 )   2021.4

Metal complex lipids for fluid-fluid phase separation in co-assembled phospholipid membranes. International journal

Ryo Ohtani, Yuka Anegawa, Hikaru Watanabe, Yutaro Tajima, Masanao Kinoshita, Nobuaki Matsumori, Kenichi Kawano, Saeko Yanaka, Koichi Kato, Masaaki Nakamura, Masaaki Ohba, Shinya Hayami

Angewandte Chemie (International ed. in English)   60 ( 24 )   13603 - 13608   2021.3

Comprehensive characterization of oligosaccharide conformational ensembles with conformer classification by free-energy landscape via reproductive kernel Hilbert space

Tokio Watanabe, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, Koichi Kato

Physical Chemistry Chemical Physics   2021.3

A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems. International journal

Nobuhiro Sato, Rina Yogo, Saeko Yanaka, Anne Martel, Lionel Porcar, Ken Morishima, Rintaro Inoue, Taiki Tominaga, Takao Arimori, Junichi Takagi, Masaaki Sugiyama, Koichi Kato

Journal of biochemistry   2021.2

Characterization of new DNA Aptamers for anti-HIV-1 Reverse Transcriptase. International journal

Supa Hannongbua, Siriluk Ratanabunyong, Niran Aeksiri, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kiattawee Choowongkomol

Chembiochem : a European journal of chemical biology   22 ( 5 )   915 - 923   2020.10

Silkworm Pupae Function as Efficient Producers of Recombinant Glycoproteins with Stable-Isotope Labeling. International journal

Hirokazu Yagi, Saeko Yanaka, Rina Yogo, Akari Ikeda, Masayoshi Onitsuka, Toshio Yamazaki, Tatsuya Kato, Enoch Y Park, Jun Yokoyama, Koichi Kato

Biomolecules   10 ( 11 )   2020.10

Residual Structure of Unfolded Ubiquitin as Revealed by Hydrogen/Deuterium-Exchange 2D NMR. International journal

Maho Yagi-Utsumi, Mahesh S Chandak, Saeko Yanaka, Methanee Hiranyakorn, Takashi Nakamura, Koichi Kato, Kunihiro Kuwajima

Biophysical journal   119 ( 10 )   2029 - 2038   2020.10

NMR Characterization of Conformational Interconversions of Lys48-Linked Ubiquitin Chains Reviewed

Methanee Hiranyakorn, Saeko Yanaka, Tadashi Satoh, Thunchanok Wilasri, Benchawan Jityuti, Maho Yagi-Utsumi, Koichi Kato

International Journal of Molecular Sciences   21 ( 15 )   5351 - 5351   2020.7

Pseudo-membrane jackets: Two-dimensional coordination polymers achieving visible phase separation in cell membrane. Reviewed International journal

Ryo Ohtani, Kenichi Kawano, Masanao Kinoshita, Saeko Yanaka, Hikaru Watanabe, Kenji Hirai, Shiroh Futaki, Nobuaki Matsumori, Hiroshi Uji-I, Masaaki Ohba, Koichi Kato, Shinya Hayami

Angewandte Chemie (International ed. in English)   59 ( 41 )   17931 - 17937   2020.6

Characterization of amyloid β fibril formation under microgravity conditions. Reviewed International journal

6   17 - 17   2020.6

Current status and issues of protein solution biophysics-Session 1SDP. Reviewed International journal

Saeko Yanaka, Susumu Uchiyama

Biophysical reviews   12 ( 2 )   263 - 264   2020.4

Editorial for the Special Issue of Biophysical Reviews focused on the Biophysical Society of Japan with select scientific content from the 57th BSJ annual meeting, Miyazaki, Japan. Reviewed International journal

Tamiki Komatsuzaki, Haruki Nakamura, Jeremy Tame, Saeko Yanaka, Takeharu Nagai, Kuniaki Nagayama

Biophysical reviews   12 ( 2 )   183 - 185   2020.3

Newly developed Laboratory-based Size exclusion chromatography Small-angle x-ray scattering System (La-SSS) Reviewed

Rintaro Inoue, Tatsuo Nakagawa, Ken Morishima, Nobuhiro Sato, Aya Okuda, Reiko Urade, Rina Yogo, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kazuki Omoto, Kazuki Ito, Masaaki Sugiyama

Scientific Reports   9 ( 1 )   12610   2019.12

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody Reviewed

Hiroki Akiba, Hiroko Tamura, Masato Kiyoshi, Saeko Yanaka, Kenji Sugase, Jose M. M. Caaveiro, Kouhei Tsumoto

Scientific Reports   9 ( 1 )   15481   2019.12

Remodeling of the Oligosaccharide Conformational Space in the Prebound State To Improve Lectin-Binding Affinity. Reviewed International journal

Tatsuya Suzuki, Saeko Yanaka, Tokio Watanabe, Gengwei Yan, Tadashi Satoh, Hirokazu Yagi, Takumi Yamaguchi, Koichi Kato

Biochemistry   59 ( 34 )   3180 - 3185   2019.10

Mutational and Combinatorial Control of Self-Assembling and Disassembling of Human Proteasome α Subunits Reviewed

20 ( 9 )   2308 - 2308   2019.5

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. Reviewed

mAbs   2018.12

Backbone ¹H, ¹³C, and ¹⁵N assignments of the extracellular region of human Fcγ receptor IIIb. Reviewed International journal

12 ( 1 )   201 - 204   2018.2

Structure and Dynamics of Immunoglobulin G Glycoproteins. Reviewed

Yagi H, Yanaka S, Kato K

Advances in experimental medicine and biology   1104   219 - 235   2018.1

Theoretical and Experimental Studies on Inclusion Complexes of Pinostrobin and β-Cyclodextrins. Reviewed

86 ( 1 )   2018.1

Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa. Reviewed

7 ( 1 )   13780   2017.10

Formation of the chaperonin complex studied by 2D NMR spectroscopy. Reviewed

Takenaka T, Nakamura T, Yanaka S, Yagi-Utsumi M, Chandak MS, Takahashi K, Paul S, Makabe K, Arai M, Kato K, Kuwajima K

PloS one   12 ( 10 )   e0187022   2017.10

Characterization of conformational deformation-coupled interaction between immunoglobulin G1 Fc glycoprotein and a low-affinity Fcγ receptor by deuteration-assisted small-angle neutron scattering. Reviewed

12   1 - 4   2017.8

Elucidation of potential sites for antibody engineering by fluctuation editing Reviewed

Saeko Yanaka, Yoshitaka Moriwaki, Kouhei Tsumoto, Kenji Sugase

SCIENTIFIC REPORTS   7 ( 1 )   9597   2017.8

Exploration of the Conformational Dynamics of Major Histocompatibility Complex Molecules Reviewed

Saeko Yanaka, Kenji Sugase

FRONTIERS IN IMMUNOLOGY   8   632   2017.5

Hyper-Assembly of Self-Assembled Glycoclusters Mediated by Specific Carbohydrate-Carbohydrate Interactions Reviewed

Gengwei Yan, Takumi Yamaguchi, Tatsuya Suzuki, Saeko Yanaka, Sota Sato, Makoto Fujita, Koichi Kato

CHEMISTRY-AN ASIAN JOURNAL   12 ( 9 )   968 - 972   2017.5

Conformational Analysis of a High-Mannose-Type Oligosaccharide Displaying Glucosyl Determinant Recognised by Molecular Chaperones Using NMR-Validated Molecular Dynamics Simulation. Reviewed International journal

Tatsuya Suzuki, Megumi Kajino, Saeko Yanaka, Tong Zhu, Hirokazu Yagi, Tadashi Satoh, Takumi Yamaguchi, Koichi Kato

Chembiochem : a European journal of chemical biology   18 ( 4 )   396 - 401   2017.2

Quantitative analysis of protein-ligand interactions by NMR Reviewed

Ayako Furukawa, Tsuyoshi Konuma, Saeko Yanaka, Kenji Sugase

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY   96   47 - 57   2016.8

Peptide-dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex Reviewed

Saeko Yanaka, Takamasa Ueno, Yi Shi, Jianxun Qi, George F. Gao, Kouhei Tsumoto, Kenji Sugase

JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 35 )   24680 - 24690   2014.8

Hyperthin nanochains composed of self-polymerizing protein shackles Reviewed

Ryo Matsunaga, Saeko Yanaka, Satoru Nagatoishi, Kouhei Tsumoto

NATURE COMMUNICATIONS   4   2211   2013.7

Interleukin-11 Links Oxidative Stress and Compensatory Proliferation Reviewed

Takashi Nishina, Sachiko Komazawa-Sakon, Saeko Yanaka, Xuehua Piao, Dong-Mei Zheng, Jiang-Hu Piao, Yuko Kojima, Shunhei Yamashina, Emiko Sano, Tracy Putoczki, Takahiro Doi, Takashi Ueno, Junji Ezaki, Hiroko Ushio, Matthias Ernst, Kouhei Tsumoto, Ko Okumura, Hiroyasu Nakano

SCIENCE SIGNALING   5 ( 207 )   ra5   2012.1

Non-core Region Modulates Interleukin-11 Signaling Activity GENERATION OF AGONIST AND ANTAGONIST VARIANTS Reviewed

Saeko Yanaka, Emiko Sano, Norio Naruse, Kin-ichiro Miura, Mutsumi Futatsumori-Sugai, Jose M. M. Caaveiro, Kouhei Tsumoto

JOURNAL OF BIOLOGICAL CHEMISTRY   286 ( 10 )   8085 - 8093   2011.3

Contribution of the flexible loop region to the function of staphylococcal enterotoxin B Reviewed

Saeko Yanaka, Motonori Kudou, Yoshikazu Tanaka, Takumi Sasaki, Sumiyo Takemoto, Atsuko Sakata, Yukio Hattori, Tomoyuki Koshi, Shiro Futaki, Kouhei Tsumoto, Toshihiro Nakashima

PROTEIN ENGINEERING DESIGN & SELECTION   23 ( 5 )   415 - 421   2010.5

Impact of Intrinsic Cooperative Thermodynamics of Peptide-MHC Complexes on Antiviral Activity of HIV-Specific CTL Reviewed

Chihiro Motozono, Saeko Yanaka, Kouhei Tsumoto, Masafumi Takiguchi, Takamasa Ueno

JOURNAL OF IMMUNOLOGY   182 ( 9 )   5528 - 5536   2009.5

Isothiocyanate inhibits restitution and wound repair after injury in the stomach: Ex vivo and in vitro studies Reviewed

Regina Ragasa, Eiji Nakamura, Lisa Marrone, Saeko Yanaka, Shusaku Hayashi, Koji Takeuchi, Susan J. Hagen

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   323 ( 1 )   1 - 9   2007.10

抗体のNMR解析のための安定同位体標識法の開発と応用

谷中冴子, 與語理那, 山崎俊夫, 宮ノ入洋平, 矢木宏和, 加藤晃一

2019.11 

膜を舞台にする抗体機能の高速原子間力顕微鏡解析

與語理那, 谷中冴子渡辺大輝, 矢木宏和, 内橋貴之, 加藤晃一

日本薬学会年会要旨集(CD-ROM)  2019.3 

IgGとFc受容体の相互作用におけるFab領域の新規結合部位の同定

與語理那, 與語理那, 山口祐希, 渡辺大輝, 矢木宏和, 佐藤匡史, 中西真人, 鬼塚正義, 大政健史, 嶋田麻里, 丸野孝浩, 鳥巣哲生, 渡邊史生, 肥後大輔, 内橋貴之, 内橋貴之, 谷中冴子, 谷中冴子, 内山進, 内山進, 加藤晃一, 加藤晃一

日本生化学会大会(Web)  2019.3 

The Dynamic Peptide Recognition And Stabilization Mechanism Of Human Leukocyte Antigen B*35:01

Saeko Yanaka, Takamasa Ueno, Kouhei Tsumoto, Kenji Sugase

PROTEIN SCIENCE   2014.7

若手の会によるフォーラム開催の報告

谷中 冴子, 飯島 玲生

生化學   2012.5

Isothiocyanate blocks restitution and wound repair in the mammalian stomach by inhibiting both monocarboxylate and bicarbonate transport activity

Regina Ragasa, Eiji Nakamura, Lisa M. Marrone, Saeko Yanaka, Shusaku Hayashi, Koji Takeuchi, Susan J. Hagen

GASTROENTEROLOGY   2007.4

先端計測アプローチの統合による抗体の構造動態と機能発現の連関機構の解明

Grant number：19H01017  2019 - 2022

日本学術振興会  科学研究費助成事業  基盤研究(A)

抗体とFc受容体の新規相互作用様式の解明と抗体工学への展開

2018 - 2019

日本学術振興会  科学研究費助成事業  若手研究

抗体の分子認識を契機とする補体系の活性化を活写する

2017 - 2018

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

多元的構造生物学アプローチによるプロテアソーム形成機構の解明と創薬への展開

Grant number：15H02491  2015 - 2018

日本学術振興会  科学研究費助成事業  基盤研究(A)

生命分子の動的秩序形成におけるミクロ‐マクロ相関の探査と設計原理の探求

Grant number：25102008  2013 - 2017

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

抗原抗体相互作用の動的構造解析を基盤とした高機能抗体の設計

2013 - 2015

日本学術振興会  科学研究費助成事業  特別研究員奨励費

ヒト主要組織適合複合体の揺らぎと細胞の抗原提示能に関する研究

Grant number：11J06193  2011 - 2012

日本学術振興会  科学研究費助成事業  特別研究員奨励費