Spinal A 3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats Invited Reviewed International journal

Heather Leduc-Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini, Tuan Trang

Journal of neuroscience research   2022.1

Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity Invited Reviewed International journal

Charlie H T Kwok, Yuta Kohro, Michael Mousseau, Melissa S O'Brien, John R Matyas, Jason J McDougall, Tuan Trang

Frontiers in immunology   2021.4

Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6. Invited Reviewed International journal

Teruaki Ono, Yuta Kohro, Keita Kohno, Hidetoshi Tozaki-Saitoh, Yasuharu Nakashima, Makoto Tsuda

Brain, behavior, and immunity   2020.7

Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor. Invited Reviewed International journal

Keisuke Koga, Ryo Yamagata, Keita Kohno, Takuya Yamane, Miho Shiratori-Hayashi, Yuta Kohro, Hidetoshi Tozaki-Saitoh, MakotoTsuda

Journal of Allergy and Clinical Immunology   2019.11

Astrocytic Ca²⁺ responses in the spinal dorsal horn by noxious stimuli to the skin Reviewed

Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

Journal of Pharmacological Sciences   2018.1

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats Reviewed

5 ( 1 )   2018.1

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents Reviewed

Keita Kohno, Junko Kitano, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

Biological and Pharmaceutical Bulletin   41 ( 7 )   1096 - 1102   2018.1

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours Reviewed International journal

Keisuke Koga, Kensho Kanehisa, Yuta Kohro, Miho Shiratori-Hayashi, Hidetoshi Saitoh, Kazuhide Inoue, Hidemasa Furue, Makoto Tsuda

SCIENTIFIC REPORTS   7   2017.7

Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch Reviewed International journal

Kensho Kanehisa, Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Saitoh, Yuta Kohro, Kenji Takamori, Makoto Tsuda

Journal of Dermatological Science   2017.6

Peripheral Nerve Injury: a Mouse Model of Neuropathic Pain Invited Reviewed International journal

Takahiro Masuda, Yuta Kohro, Kazuhide Inoue, Makoto Tsuda

Bio-protocol   2017.5

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed International journal

Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Akamine Takahiro, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W salter, Kazuhide Inoue, Shigehiro Ohdo

NATURE COMMUNICATIONS   7   2016.10

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain Reviewed International journal

Takahiro Masuda, Yui Ozono, Satsuki Mikuriya, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Ken Iwatsuki, Hisayuki Uneyama, Reiko Ichikawa, Michael W salter, Makoto Tsuda, Kasuhide Inoue

NATURE COMMUNICATIONS   7   2016.8

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury Reviewed International journal

Ryoichi Tashima, Daisuke Tomiyama, Miho Shiratori, Tomohiro Yamashita, Yuta Kohro, Hidetoshi Saitoh, Kazuhide Inoue, Makoto Tsuda

SCIENTIFIC REPORTS   6   2016.3

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn. Reviewed International journal

Yuta Kohro, Emi Sakaguchi, Ryoichi Tashima, Hidetoshi Saitoh, Hideyuki Okano, Kazuhide Inoue, Takahiro Masuda et al.

Scientific Reports   2015.9

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch Reviewed International journal

Miho Shiratori, Keisuke Koga, Hidetoshi Saitoh, Yuta Kohro, Honami Toyonaga, Chiharu Yamaguchi, Ayumi Hasegawa, Takeshi Nakahara, Junichi Hachisuka, Shizuo Akira, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

NATURE MEDICINE   21 ( 8 )   927 - 931   2015.8

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.

Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K

BRAIN   134 ( 4 )   2011.4

Role of PAF Receptor in Proinflammatory Cytokine Expression in the Dorsal Root Ganglion and Tactile Allodynia in a Rodent Model of Neuropathic Pain

Shigeo Hasegawa, Yuta Kohro, Miho Shiratori, Satoshi Ishii, Takao Shimizu, Makoto Tsuda, Kazuhide Inoue

PLOS ONE   5 ( 5 )   2010.5

Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.

Shigeo Hasegawa, Yuta Kohro, Makoto Tsuda, Kazuhide Inoue

Mol Pain   2009.5

Modulation of mechanosensory behavior by a subpopulation of spinal astrocytes

Yuta Kohro, Makoto Tsuda

2023.7 

脊髄アストロサイトから紐解く感覚情報伝達の調節メカニズム

高露雄太、松田烈士、吉原康平、津田誠

第100回生理学会  2023.3 

中枢末梢連関障害に起因する非細胞自律性神経機能障害の新展開

高露雄太、松田烈士、吉原康平、津田誠

第96回日本薬理学会年会  2022.12 

Sensitizing mechanosensory information by a population of spinal dorsal horn astrocytes International conference

Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Ryuichi Katsuragi,Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

17th World Congress on Pain  2018.9 

The role of region-specific spinal dorsal horn astrocytes in sensory information processing

Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

2017.9 

D-セリンシグナルを介した脊髄後角アストロサイトによる触覚情報の変調作用

高露雄太, 桂木龍一, 岡嵩晃, 棟田翔, 田島諒一, 齊藤 秀俊, 御子柴克彦, 井上和秀, 津田 誠

第39回日本疼痛学会  2017.6 

Modality-specific sensory information processing by spinal dorsal horn astrocytes through D-serine signaling

Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Kazuhide Inoue, Makoto Tsuda

2017.3 

Activation of spinal dorsal horn astrocytes modulates the processing of tactile sensation International conference

Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

Society for Neuroscience 2016  2016.11 

Modality-specific sensory information processing by spinal dorsal horn astrocytes International conference

Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

16th World Congress on Pain  2016.9 

脊髄後角アストロサイトの活動変化は触覚情報を変調させる

高露 雄太, 桂木龍一, 岡嵩晃, 棟田翔, 田島諒一, 齊藤 秀俊, 井上 和秀, 津田 誠

第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会  2016.9 

DREADDを用いた脊髄アストロサイトの感覚情報伝達における機能解析

高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

第38回日本疼痛学会  2016.6 

脊髄アストロサイトの活動変化は感覚情報を様式特異的に変調させる

高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

第89回日本薬理学会年会  2016.3 

光遺伝学的手法による神経障害性アロディニアの新たな評価法

田島諒一, 古賀啓祐, 高露雄太, 八尾寛, 井上和秀, 古江秀昌, 津田 誠

平成27年度生理研研究会  2015.12 

脊髄アストロサイト特異的遺伝子導入法を用いた感覚情報伝達における機能解析

高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

痛み研究会2015  2015.12 

光遺伝学的手法による神経障害性アロディニアの新規評価法

田島諒一, 古賀啓祐, 高露雄太, 八尾寛, 井上和秀, 古江秀昌, 津田 誠

第68回日本薬理学会西南部会  2015.11 

STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice International conference

Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hashisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

Society for Neuroscience 2015  2015.10 

Astrocytic lipocalin-2 in the spinal dorsal horn is required for chronic itch International conference

Miho Shiratori-Hayashi, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Takeshi Nakahara, Junichi Hashisuka, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

8th World Congress on Itch  2015.9 

Essential role for STAT3-dependent reactive astrocytes in maintenance of chronic itch

Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hashisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

2015.9 

Screening of academic papers

Role(s)： Peer review

2018

感覚情報伝達に対する脊髄後角アストロサイトの役割解明

Grant number：16K18885  2016 - 2017

科学研究費助成事業  若手研究(B)

薬物治療学Ⅱ

2023.6 - 2023.8   Summer quarter

薬学基礎実習IV

2022.10 - 2023.3   Second semester

薬学基礎実習IV

2017.10 - 2018.3   Second semester

医療薬学演習II

2017.4 - 2017.9   First semester

医療薬学演習I

2017.4 - 2017.9   First semester

薬学基礎実習Ⅳ

2016.10 - 2017.3   Second semester

医療薬学演習II

2016.4 - 2016.9   First semester

医療薬学演習I

2016.4 - 2016.9   First semester

薬学基礎実習Ⅳ

2015.10 - 2016.3   Second semester

2022.4   Role：Participation   Title：令和４年度 第１回全学ＦＤ（新任教員の研修）The 1st All-University FD (training for new faculty members) in FY2022

Organizer：University-wide

2018.5   Role：Participation   Title：「総合的創薬ソリューションプロバイダーによる創薬研究支援の新たな形」

Organizer：[Undergraduate school/graduate school/graduate faculty]

2017.3   Role：Participation   Title：情報セキュリティ対策について

Organizer：[Undergraduate school/graduate school/graduate faculty]

2016.4   Role：Participation   Title：外国人留学生受入に係る説明会

Organizer：[Undergraduate school/graduate school/graduate faculty]