Updated on 2024/06/10

Information

 

写真a

 
YAMASHITA TOMOHIRO
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Lecturer
Title
Lecturer
Contact information
メールアドレス
Profile
・慢性疼痛および慢性掻痒のメカニズム解析および治療薬の探索 ・グリーンファルマ研究
External link

Degree

  • Ph.D.

Research History

  • なし

    なし

  • なし

Research Interests・Research Keywords

  • Research theme：・Drug discovery for pain and itch. ・Greenpharma research.

    Keyword：drug screening, neuropathic pain, itch, MRGPR, DRG neuron, microglia, ATP receptors

    Research period： 2018.4

Papers

  • Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment. International journal

    Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, Taisei Kumamoto, Kosuke Oyama, Takashi Ogino, Akito Tsuruta, Kouta Mayanagi, Tomohiro Yamashita, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu, Hitomi Kawakami, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

    Translational research : the journal of laboratory and clinical medicine   2024.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.trsl.2024.02.004

  • Inhibition of tumor-derived CCL2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice. International journal

    #Marie Taniguchi, #Sai Yasukochi, #Wakaba Yamakawa, @Yuya Tsurudome, @Akito Tsuruta, @Michiko Horiguchi, @Kentaro Ushijima, @Tomohiro Yamashita, @Naoya Shindo, @Akio Ojida,@ Naoya Matsunaga, @Satoru Koyanagi, @Shigehiro Ohdo

    Molecular pharmacology   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1124/molpharm.123.000690

  • GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice. Reviewed International journal

    #Teruaki Ono, @Tomohiro Yamashita, #Ryota Kano, Mariko Inoue, #Shota Okada, Koki Kano, @Schuichi Koizumi, @Kazuhisa Iwabuchi, @Yoshio Hirabayashi,@ Ichiro Matsuo, @Yasuharu Nakashima, @Hiroyuki Kamiguchi, @Yuta Kohro, @Makoto Tsuda

    Brain, behavior, and immunity   110   276 - 287   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbi.2023.03.008

  • Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors. Reviewed

    Ryoko Sasaki, Mary Ann Suico, Keisuke Chosa, Yuriko Teranishi, Takashi Sato, Asuka Kagami, Shunsuke Kotani, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto, @Tomohiro Yamashita, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, Tsuyoshi Shuto

    Journal of pharmacological sciences   151 ( 1 )   54 - 62   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jphs.2022.11.004

  • Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis Reviewed International journal

    596 ( March 12 )   22 - 28   2022.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2022.01.066

  • New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth Reviewed International journal

    #Akiko Sagara, @Kohei Nakata,@Tomohiro Yamashita, Weiyu Guan, Pingshan Zhong, Sokichi Matsumoto, Sho Endo, Chika Iwamoto, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, @Kenoki Ohuchida , @Kazuhiro Mizumoto, @Masafumi Nakamura

    Pancreatology   2021.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1 beta Release: An Involvement in its Alleviating Effect on Neuropathic Pain Reviewed International journal

    @Yamashita, Tomohiro; #Kamikaseda, Sawako; #Tanaka, Aya; @Tozaki-Saitoh, Hidetoshi; @Caaveiro, Jose M. M.; @Inoue, Kazuhide; @Tsuda, Makoto

    CELLS   10 ( 2 )   2021.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/cells10020434

  • Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-kappa B-Inhibitory Activity Reviewed International journal

    @Yoritate, Makoto; #Morita, Yuki; Gemander, Manuel; @Morita, Masaki; @Yamashita, Tomohiro; @Sodeoka, Mikiko; @Hirai, Go

    ORGANIC LETTERS   22 ( 22 )   8877 - 8881   2020.11

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.orglett.0c03255

  • Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors Reviewed

    2020.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via β-adrenergic receptors (β-ARs). Microglia, resident macrophages in the CNS, have a central role in the brain immune system and have been reported to be activated by NA. However, intracellular signaling mechanisms of the AR-mediated proinflammatory responses of microglia are not fully understood. Using a rapid and stable in vitro reporter assay system to evaluate IL-1β production in microglial BV2 cells, we found that NA and the β-AR agonist isoproterenol upregulated the IL-1β reporter activity. This effect was suppressed by β-AR antagonists. We further examined the involvement of EPAC (exchange protein directly activated by cAMP) and TPL2 (tumor progression locus 2, MAP3K8) and found that inhibitors for EPAC and TPL2 reduced AR agonist-induced IL-1β reporter activity. These inhibitors also suppressed NA-induced endogenous Il1b mRNA expression and IL-1β protein production. Our results suggest that EPAC and TPL2 are involved in β-AR-mediated IL-1β production in microglial cells, and extend our understanding of its intracellular signaling mechanism.

    DOI： 10.1016/j.jphs.2020.03.004

  • Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1 Reviewed

    Ryoko Igarashi, Shun-Ichi Yamashita, Tomohiro Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Takeo Fukuchi, Tomotake Kanki

    Scientific reports   10 ( 1 )   1465   2020.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-020-58315-w

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes Reviewed

    Kazuhiro Nishiyama, Takuro Numaga-Tomita, Yasuyuki Fujimoto, Tomohiro Tanaka, Chiemi Toyama, Akiyuki Nishimura, Tomohiro Yamashita, Matsunaga Naoya, Koyanagi Satoru, Yasu Taka Azuma, Yuko Ibuki, Koji Uchida, Shigehiro Ohdo, Motohiro Nishida

    British Journal of Pharmacology   176 ( 18 )   3723 - 3738   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/bph.14777

  • Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure Reviewed

    Tatsuhiro Igawa, Shuhei Kishikawa, Yoshito Abe, Tomohiro Yamashita, Saki Nagai, Mitsunori Shiroishi, Chinatsu Shinozaki, Hiroyuki Tanaka, Hidetoshi Saitoh, Tsuda Makoto, Kazuhide Inoue, Tadashi Ueda

    Purinergic Signalling   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11302-019-09646-5

  • New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats Reviewed International journal

    Shota Yamamoto, Tomohiro Yamashita, Mayu Ito, Jose Manuel Martinez Caaveiro, Nobuaki Egashira, Hidetoshi Saitoh, Tsuda Makoto

    International Journal of Cancer   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ijc.32043

  • Green Pharma A New Strategy for Drug Discovery in Academia by Targeting Glial Cells and ATP Receptors Reviewed

    Tomohiro Yamashita, Tsuda Makoto, Hidetoshi Saitoh, Kazuhide Inoue

    Yakugaku Zasshi   138 ( 8 )   1027 - 1031   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1248/yakushi.17-00211-1

  • P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C–C chemokine 3 expression Reviewed

    141 ( 1 )   100 - 110   2017.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    Microglia are widely accepted as surveillants in the central nervous system that are continually searching the local environment for signs of injury. Following an inflammatory situation, microglia alter their morphology, extend ramified processes, and undergo cell body hypertrophy. Extracellular nucleotides are recognized as a danger signal by microglia. ADP acting on P2Y12 receptors induce process extension of microglia thereby attracting microglia to the site of adenosine tri-phosphate/ADP leaking or release. However, the question whether ADP/P2Y12 receptor signaling directly stimulates the production or release of inducible factors such as cytokines remains unclear. In this study, we found that CC chemokine ligand 3 (CCL3) is induced by ADP-treated primary microglia. Pharmacological characterization using pertussis toxin, a P2Y12 receptor inhibitor, and a calcium chelator revealed that CCL3 induction was caused by P2Y12 receptor-mediated intracellular calcium elevation. Next, nuclear factor of activated T-cell dephosphorylation and nuclear translocalization were observed. Calcineurin, an inhibitor for nuclear factor of activated T cell, suppressed CCL3 induction. These data indicate that microglial P2Y12 receptors are utilized to trigger an acute inflammatory response in microglia via rapid CCL3 induction after ADP stimulation. (Figure presented.).

    DOI： 10.1111/jnc.13968

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease Reviewed

    Matsunaga Naoya, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Tsuda Makoto, Kazuhide Inoue, Akio Ojida, Koyanagi Satoru, Shigehiro Ohdo

    EBioMedicine   13   262 - 273   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ebiom.2016.10.008

  • Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury Reviewed

    Tomohiro Yamashita, Shota Yamamoto, Jiaming Zhang, Miho Kometani, Daisuke Tomiyama, Keita Kohno, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

    PLoS One   11 ( 10 )   2016.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0165189

  • A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain Reviewed

    Yuta Matsumura, Tomohiro Yamashita, Atsushi Sasaki, Eriko Nakata, Keita Kohno, Takahiro Masuda, Hidetoshi Saitoh, Toshiyasu Imai, Yasushi Kuraishi, Tsuda Makoto, Kazuhide Inoue

    Scientific Reports   6   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep32461

  • Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury Reviewed

    Ryoichi Tashima, Satsuki Mikuriya, Daisuke Tomiyama, Miho Shiratori, Tomohiro Yamashita, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

    Scientific Reports   6   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep23701

  • Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor Reviewed

    Tatsuhiro Igawa, Sadayuki Higashi, Yoshito Abe, Takatoshi Ohkuri, Hiroyuki Tanaka, Satoshi Morimoto, Tomohiro Yamashita, Tsuda Makoto, Kazuhide Inoue, Tadashi Ueda

    Journal of Biochemistry   153 ( 3 )   275 - 282   2013.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jb/mvs143

  • CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia Reviewed

    Emika Toyomitsu, Tsuda Makoto, Tomohiro Yamashita, Hidetoshi Saitoh, Yoshitaka Tanaka, Kazuhide Inoue

    Purinergic Signalling   8 ( 2 )   301 - 310   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11302-011-9288-x

  • Antidepressants inhibit P2X4 receptor function A possible involvement in neuropathic pain relief Reviewed

    Kenichiro Nagata, Toshiyasu Imai, Tomohiro Yamashita, Tsuda Makoto, Hidetoshi Saitoh, Kazuhide Inoue

    Molecular Pain   5   2009.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1744-8069-5-20

  • Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor Reviewed

    Tsuda Makoto, Satoshi Ishii, Takahiro Masuda, Shigeo Hasegawa, Koji Nakamura, Kenichiro Nagata, Tomohiro Yamashita, Hidemasa Furue, Hidetoshi Saitoh, Megumu Yoshimura, Schuichi Koizumi, Takao Shimizu, Kazuhide Inoue

    Journal of Neurochemistry   102 ( 5 )   1658 - 1668   2007.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1471-4159.2007.04796.x

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Presentations

  • Therapeutic Approach for the Treatment of Neuropathic Pain by the Inhibition of Microglial P2X7 Receptors by Approved Drugs Invited International conference

    @Tomohiro Yamashita, #Sawako Kamikaseda, #Aya Tanaka, @Hidetoshi Tozaki-Saitoh, @Jose M. M. Caaveiro, @Kazuhide Inoue, @Makoto Tsuda

    Purines 2021  2021.6 

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    Event date： 2021.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Drug discovery technologies to achieve pain relief through drug repositioning approaches（ドラッグリポジショニングによる疼痛緩和を達成するための創薬技術） Invited

    @山下智大

    第92回日本薬理学会年会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • Microglial ATP receptors in neuropathic pain Invited International conference

    @Tomohiro Yamashita

    PURINES 2018  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Brazil  

  • 化合物スクリーニングによって発見した新たなMRGPRA3アゴニストは非ヒスタミン性のかゆみを誘発する

    山下 智大,#伊藤 麻結, #川浪 侑華, @古賀 啓祐, #兼久 賢章, #藤井 志織, 津田 誠

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese  

    Country：Japan  

  • BINDS九州大学拠点が実施する化合物スクリーニング支援と高度化 Invited

    山下智大

    徳島大学・九州大学BINDS合同シンポジウム  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 九大薬が取り組む「グリーンファルマ研究」とは？

    山下智大

    令和5年度九州大学薬学研究院公開講座  2023.10 

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    Event date： 2023.10

    Language：Japanese  

    Country：Japan  

  • A newly discovered MRGPRA3 agonist by high-throughput screening induces scratching behaviors

    @Tomohiro Yamashita, Mayu Ito, Yuka Kawanami, Keisuke Koga, Kensho Kanehisa, Shiori Fujii, @Jose M. M. Caaveiro, @Makoto Tsuda.

    2022.3 

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    Event date： 2022.3

    Language：English  

    Country：Japan  

  • グリーンファルマという新たな創薬システムを成功させるために九州大学が取り組む包括的な支援 Invited

    @山下智大

    長崎大学BINDS利用セミナー  2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：オンライン   Country：Japan  

    アカデミアで発見した有望な創薬標的分子に対して薬理作用を発揮する既承認薬を見出し、さらにその既存の薬をもとに新薬を創製する新たな創薬システム「グリーンファルマ」を成功させるため、九州大学では化合物スクリーニング、ヒット化合物の最適化、動物での動態解析さらには疾患モデルでの解析などの包括的な支援を実施する。本セミナーではグリーンファルマの仕組みおよび支援体制について具体的な成果事例を交えて紹介する。

  • Discovery of a new MrgprA3 agonist and evaluation of its effect for itch sensation 新規MrgprA3アゴニストの発見およびかゆみ感覚に対するその評価

    ＠Tomohiro Yamashita, #Mayu Ito, #Yuka Kawanami, @Keisuke Koga, #Kensho Kanehisa, #Shiori Fujii, @Miho Shiratori-Hayashi, @Makoto Tsuda

    第93回日本薬理学会年会（誌上開催）  2020.3 

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    Event date： 2020.3

    Language：English  

    Venue：誌上開催   Country：Japan  

  • アカデミアが実践するニューロンおよびグリア細胞を標的とした疼痛治療戦略

    @山下智大

    第72回日本薬理学会西南部会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：那覇   Country：Japan  

  • グリーンファルマ研究が切り拓くアカデミアにおける新たな創薬戦略 Invited

    @山下智大

    薬物動態談話会 第42年会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：浜松   Country：Japan  

  • オキサリプラチン誘発末梢神経障害に対する乳がん治療薬フルベストラントの保護効果

    @山下智大, @山本将大, #伊藤麻結, @カアベイロホセ, @江頭伸昭, @齊藤秀俊, @津田誠

    第13回日本緩和医療薬学会年会  2019.6 

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    Event date： 2019.5 - 2019.6

    Language：Japanese  

    Venue：千葉   Country：Japan  

  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury International conference

    2018.7 

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    Event date： 2018.7

    Language：English  

    Venue：Kyoto   Country：Japan  

  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury International conference

    2018.7 

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    Event date： 2018.7

    Language：English  

    Venue：Kyoto   Country：Japan  

  • グリア細胞およびATP受容体を標的としたアカデミア創薬の実現に向けた「グリーンファルマ研究」の取り組み

    @山下智大，@齊藤秀俊，@津田誠，@井上和秀,

    薬学会137年会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • デュロキセチンによるミクログリアに発現するP2X4受容体の阻害作用および末梢神経損傷に伴う神経障害性疼痛に対する改善効果

    @山下智大, #山本将大, #張佳明，@齊藤秀俊，@津田誠，@井上和秀

    第90回日本薬理学会年会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長崎   Country：Japan  

  • Searching for analgesics targeted at P2X4 receptors by screening of well-established drugs. International conference

    @Tomohiro Yamashita, @Makoto Tsuda, @Hidetoshi Tozaki-Saitoh, @Kazuhide Inoue

    Purines 2014  2014.7 

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    Event date： 2014.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Germany  

  • デュロキセチンによるミクログリアに発現するP2X4受容体の阻害作用および末梢神経損傷に伴う神経障害性疼痛に対する改善効果

    山下 智大

    第90回日本薬理学会年会  2017.3 

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    Language：Japanese  

    Country：Other  

  • グリア細胞およびATP受容体を標的としたアカデミア創薬の実現に向けた「グリーンファルマ研究」の取り組み

    山下 智大

    薬学会137年会  2017.3 

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    Language：Japanese  

    Country：Other  

  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury International conference

    山下 智大

    2018.6 

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    Language：English  

    Country：Other  

  • Microglial ATP receptors in neuropathic pain Invited International conference

    Purines 2018  2018.6 

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    Language：English  

    Country：Other  

    Microglial ATP receptors in neuropathic pain

  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury WCP2018 International conference

    山下 智大

    2018.7 

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    Language：English  

    Country：Other  

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MISC

  • エコファーマによる新規神経障害性疼痛治療薬の探索

    #山下智大

    ファルマシア55巻03号   2019.3

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    Language：Japanese  

Professional Memberships

  • 日本薬学会

  • 日本薬理学会

  • 日本緩和医療薬学会

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2021

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • 不明

    日本薬理学会　次世代の会  2019.4 - 2020.3

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2017

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

  • Screening of academic papers

    Role(s)： Peer review

    2016

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

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Research Projects

  • かゆみの伝達および慢性化にかかわるMRGPRsの多様性解明と新たな治療薬の創出

    Grant number：24K10034  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • オートファジー依存性がん抗原放出機構の解明および免疫提示システムの強化改変

    Grant number：23H02982  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリーンファルマ創薬構造解析による支援高度化の推進

    2022 - 2026

    AMED 創薬等ライフサイエンス研究支援基盤事業

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • PTPN3を標的とする非抗体型免疫チェックポイント阻害剤を用いた癌免疫治療開発

    Grant number：22K08715  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 抗P2X4抗体Fabの構造を基盤とした大腸菌発現の改良およびFabの高機能化

    Grant number：21K06517  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • かゆみ伝達に対するMRGPRの包括的研究および創薬シーズの探索

    Grant number：21K06804  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 非天然α-アミノ酸を用いた中分子ペプチド医薬品創成

    2021 - 2023

    AMED 創薬基盤推進研究事業

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 神経障害性疼痛に直結する神経回路動作異常メカニズムの解明と創薬への応用

    Grant number：19H05658  2019 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(S)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 制御化合物から紐解くかゆみ伝達におけるMrgprの役割そして創薬への応用

    Grant number：19K16502  2019 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • P2X4に対する高親和性抗体を利用した痛みを抑制する誘導体化抗体の開発

    Grant number：18K06597  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリーンファルマを基盤にした創薬オープンイノベーションの推進

    2017 - 2021

    AMED 創薬等ライフサイエンス研究支援基盤事業

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • ミクログリアに起因する慢性炎症を制御する新規治療薬の探索研究

    Grant number：17K17947  2017 - 2018

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • オートファジーによるミトコンドリアDNA分解の分子機構と生理的意義の解析

    Grant number：17K15088  2017 - 2018

    科学研究費助成事業  若手研究(A,B)

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    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Scientific research funding

  • 慢性疼痛における糖脂質シグナルの作動機序解明と創薬に向けた研究

    2016 - 2021

    AMED 革新的先端研究開発支援事業

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 免疫アレルギー疾患等実用化研究事業, 分担, 皮膚バリアに影響する一次求心性神経由来シグナル分子の特定

    2016 - 2018

    AMED 免疫アレルギー疾患等実用化研究事業

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • オートファジーによって分解されるミトコンドリアの形態制御機構の解明

    Grant number：15K18501  2015 - 2016

    科学研究費助成事業  若手研究(A,B)

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    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Scientific research funding

  • ミトコンドリアオートファジー関連薬物の探索

    Grant number：25560414  2013 - 2014

    科学研究費助成事業  萌芽研究

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

▼display all

Class subject

  • 創薬化学

    2023.6 - 2023.8   Summer quarter

  • 薬理基礎理論

    2022.10 - 2023.3   Second semester

  • 医療系薬学英語講義

    2021.10 - 2022.3   Second semester

  • 薬理・疾患治療

    2021.10 - 2022.3   Second semester

FD Participation

  • 2023.11   Role：Participation   Title：第２回部局FD講演会「機関間連携」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role：Participation   Title：令和５年度４部局合同男女共同参画ＦＤ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.11   Role：Participation   Title：第４回創薬産学官連携セミナー（アカデミア創薬）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Title：学生の多様性に対応した教育とは：障害学生への合理的配慮を中心に

  • 2022.3   Role：Participation   Title：第3回創薬産学官連携セミナー（感染症研究拠点WG共催）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Title：JST 次世代研究者挑戦的研究プログラム 説明会

  • 2021.5   Role：Participation   Title：第2回創薬産学官連携セミナー

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.2   Role：Participation   Title：創薬産学官連携セミナー

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.9   Role：Participation   Title：外国人研究者・留学生受け入れ、貨物輸出と技術の提供に関して

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role：Participation   Title：M2B/Moodleに関するFD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Social Activities

  • 不明

    令和5年度九州大学薬学研究院公開講座  九州大学コラボ・ステーションⅠ 視聴覚ホール  2023.10

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture