NOGUCHI YASUNORI
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Assistant Professor
Title
Assistant Professor
External link
Degree
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Ph.D. in Pharmaceutical Sciences
Research History
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Imperial College London
Papers
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The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer Reviewed International journal
Saleh, Almutasem*; Noguchi, Yasunori*; Aramayo, Ricardo; Ivanova, Marina E.; Stevens, Kathryn M.; Montoya, Alex; Sunidhi, S.; Carranza, Nicolas Lopez; Skwark, Marcin J.; Speck, Christian; *Contributed equally
NATURE COMMUNICATIONS 13 ( 1 ) 2022.5
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The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6 Reviewed International journal
Feng, Xiang; Noguchi, Yasunori; Barbon, Marta; Stillman, Bruce; Speck, Christian; Li, Huilin
NATURE COMMUNICATIONS 12 ( 1 ) 2021.6
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Regulatory dynamics in the ternary DnaA complex for initiation of chromosomal replication in Escherichia coli Invited Reviewed International journal
Sakiyama, Yukari; Kasho, Kazutoshi; Noguchi, Yasunori; Kawakami, Hironori; Katayama, Tsutomu
NUCLEIC ACIDS RESEARCH 45 ( 21 ) 12354 - 12373 2017.12
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Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model Reviewed International journal
Noguchi, Yasunori; Yuan, Zuanning; Bai, Lin; Schneider, Sarah; Zhao, Gongpu; Stillman, Bruce; Speck, Christian; Li, Huilin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 ( 45 ) E9529 - E9538 2017.11
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Near-atomic structural model for bacterial DNA replication initiation complex and its functional insights Reviewed International journal
Shimizu, Masahiro; Noguchi, Yasunori; Sakiyama, Yukari; Kawakami, Hironori; Katayama, Tsutomu; Takada, Shoji
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 ( 50 ) E8021 - E8030 2016.12
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The Escherichia coli Cryptic Prophage Protein YfdR Binds to DnaA and Initiation of Chromosomal Replication Is Inhibited by Overexpression of the Gene Cluster yfdQ-yfdR-yfdS-yfdT Reviewed International journal
Noguchi, Yasunori; Katayama, Tsutomu
FRONTIERS IN MICROBIOLOGY 7 2016.3
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The Arg Fingers of Key DnaA Protomers Are Oriented Inward within the Replication Origin oriC and Stimulate DnaA Subcomplexes in the Initiation Complex Reviewed International journal
Noguchi, Yasunori; Sakiyama, Yukari; Kawakami, Hironori; Katayama, Tsutomu
JOURNAL OF BIOLOGICAL CHEMISTRY 290 ( 33 ) 20295 - 20312 2015.8
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A Replicase Clamp-Binding Dynamin-like Protein Promotes Colocalization of Nascent DNA Strands and Equipartitioning of Chromosomes in E. coli Reviewed International journal
Ozaki, Shogo; Matsuda, Yusaku; Keyamura, Kenji; Kawakami, Hironori; Noguchi, Yasunori; Kasho, Kazutoshi; Nagata, Komomo; Masuda, Tamami; Sakiyama, Yukari; Katayama, Tsutomu
CELL REPORTS 4 ( 5 ) 985 - 995 2013.9
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Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex Reviewed International journal
Shogo Ozaki, Yasunori Noguchi, Yasuhisa Hayashi, Erika Miyazaki, Tsutomu Katayama
Journal of Biological Chemistry 287 ( 44 ) 37458 - 37471 2012.10
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Stable nucleotide binding to DnaA requires a specific glutamic acid residue within the AAA+ box II motif Reviewed International journal
Shogo Ozaki, Yasunori Noguchi, Masahiro Nishimura, Tsutomu Katayama
Journal of Structural Biology 179 ( 2 ) 242 - 250 2012.8
Presentations
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DNA複製開始におけるMCM2-7活性化の分子機構 Invited
野口 泰徳
国⽴遺伝学研究所研究会「染⾊体安定維持研究会」 2023.7
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Molecular mechanism of the DDK-dependent MCM2-7 activation Invited
2023.11
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Molecular mechanism of the MCM2-7 activation by DDK International conference
Yasunori Noguchi, Almutasem Saleh, Sarah Schneider, and Marina Ivanova, and Christian Speck
NIG International Symposium 2022, Chromosome Replication in the New Era; Old and New Questions in Life Science 2022.11
MISC
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From structure to mechanism-understanding initiation of DNA replication Reviewed
Alberto Riera, Marta Barbon, Yasunori Noguchi, L Maximilian Reuter, Sarah Schneider, Christian Speck
2017.6
Professional Memberships
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日本生化学会
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日本分子生物学会
Research Projects
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ヒト細胞DNA複製メカニズムの 解明
2023.4 - 2024.3
共同研究
Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
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ヒト細胞系におけるDDKキナーゼ依存的なMCM2-7ヘリカーゼの活性化機構の解明
Grant number：23K05639 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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染色体生物学とそのがん研究への応用
2023.4 - 2023.6 Spring quarter