Updated on 2024/09/27

Information

 

写真a

 
YAMADA KEN-ICHI
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Professor
School of Pharmaceutical Sciences Department of General Pharmaceutical Sciences(Joint Appointment)
Graduate School of Pharmaceutical Sciences Department of Medicinal Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426624
Profile
2011年4月〜現在   「脂質代謝中間体検出手法開発と疾患モデルへの適用」、「生体内レドックス変動の是正による生活習慣病メカニズム解明」、「生体から分子まで異なる階層間での検出・分析を可能とするイメージング剤の開発」、「新規MRI・蛍光造影剤の開発とセラノスティックスへの応用」、「加齢黄斑変性治療薬の開発」 2009年4月〜2011年3月   「生活習慣病モデル動物での病態メカニズム解析」、「機能性有機分子の開発と生体への応用」、「抗酸化物質の探索・評価」 2002年3月〜2008年3月   「プロトン・電子二重共鳴画像化装置を用いた14N、15N標識スピンプローブの生体内分離画像解析及び新規造影剤の開発」、「融合型磁気共鳴装置の開発・応用、スピンプローブの生体内反応メカニズムの解析」 1999年9月〜  「生体計測電子スピン共鳴法及びプロトン・電子二重共鳴画像化法を用いた生体内レドックス変動、酸素濃度変動の無侵襲画像解析」 1999年4月〜  「融合型磁気共鳴装置の開発」
External link

Research Areas

  • Life Science / Pharmaceutical analytical chemistry and physicochemistry

Degree

  • PhD

Research History

  • 九州大学 大学院薬学研究院 教授

    2017.4 - Present

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Research Interests・Research Keywords

  • Research theme:酸化脂質

    Keyword:酸化脂質

    Research period: 2024

  • Research theme:酸化ストレス

    Keyword:酸化ストレス

    Research period: 2024

  • Research theme:質量分析

    Keyword:質量分析

    Research period: 2024

  • Research theme:脂質

    Keyword:脂質

    Research period: 2024

  • Research theme:加齢黄斑変性

    Keyword:加齢黄斑変性

    Research period: 2024

  • Research theme:創薬基盤研究

    Keyword:創薬基盤研究

    Research period: 2024

  • Research theme:分子イメージング

    Keyword:分子イメージング

    Research period: 2024

  • Research theme:レドックス

    Keyword:レドックス

    Research period: 2024

  • Research theme:Development of age-related macular degeneration drug

    Keyword:age-related macular degeneration

    Research period: 2014.4

  • Research theme:Drug Discovery Research Targeting Lipid Peroxidation

    Keyword:Drug Discovery Researc

    Research period: 2013.4 - 2034.3

  • Research theme:Structural Analysis of Oxidized Lipids Produced in Pathological Conditions

    Keyword:Oxidized Lipids

    Research period: 2013.4 - 2034.3

  • Research theme:Identification of Bioactive Oxidized Lipids and Elucidation of the Molecular Targets

    Keyword:Oxidized Lipids, Bioactive

    Research period: 2013.4 - 2034.3

  • Research theme:Molecular Mechanisms of Cell Death Caused by Lipid Peroxidation

    Keyword:Lipid Peroxidation, Cell Death

    Research period: 2013.4 - 2034.3

  • Research theme:Molecular Mechanisms of Oxidized Lipids-related Diseases

    Keyword:Oxidized Lipids-related Diseases

    Research period: 2013.4 - 2034.3

  • Research theme:Development of detection method for intermediate in lipid metabolism and application to animal models for inflammation and related diseases

    Keyword:fluorescence, radical, lipid

    Research period: 2012.4

  • Research theme:Research on mechanism of life style related diseases based on a treatment of redox imbalance state

    Keyword:life style related diseases, redox

    Research period: 2012.4

  • Research theme:Development of imaging probe to detect and analyze the functional molecule from whole body to cells

    Keyword:imaging, magnetic resonance, fluorescence

    Research period: 2012.4

  • Research theme:Synthesis of novel contrast agent for MRI and optical imaging and application to theranostics

    Keyword:imaging, magnetic resonance, theranostics

    Research period: 2012.4

  • Research theme:Development and application of fluorescent probe for lipid derived radicals

    Keyword:lipid derived radical, oxidative stress, fluorescence, nitroxide, ESR, MRI

    Research period: 2010.4 - 2012.3

  • Research theme:Developmet of antioxidant as a theraputic agent for oxidative stress disease

    Keyword:antioxidant, oxidative stress

    Research period: 2010.4 - 2012.3

Awards

  • 日本酸化ストレス学会 学術奨励賞

    2016.8   日本酸化ストレス学会   肥満症における生体内レドックス不均衡の是正

  • 長瀬研究振興賞

    2012.4   公益財団法人長瀬科学技術振興財団   生体内脂質ラジカルの蛍光検出手法開発と創薬への展開

  • Young Investigator Award

    2011.1   International Symposium on Free Radical Research  

  • 日本酸化ストレス学会 学術奨励賞

    2010.6   日本酸化ストレス学会   生体内レドックス反応の解析に向けた新規ニトロキシルラジカルの開発と応用

  • 第45回電子スピンサイエンス学会奨励賞

    2006.11   電子スピンサイエンス学会   生体内フリーラジカル反応・酸素濃度変動の無侵襲画像解析

  • 第3回日本NO学会学術集会、Travel Awards

    2003.5   日本NO学会   病態モデル腎組織中の一酸化酸素、脂質ラジカルの分離画像解析

  • The Takeda Enterpreneurship Award, Finalist Commendation

    2002.11   The Takeda Foundation  

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Papers

  • The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium–Glucose Transporter 2 Inhibitors

    Yamato M., Kato N., Yamada K.I., Inoguchi T.

    Diabetes   73 ( 7 )   1153 - 1166   2024.7   ISSN:00121797

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    Language:English   Publisher:Diabetes  

    The early pathogenetic mechanism of diabetic retinopa-thy (DR) and its treatment remain unclear. Therefore, we used streptozotocin-induced diabetic mice to investigate the early pathogenic alterations in DR and the protective effect of sodium–glucose cotransporter 2 (SGLT2) inhibi-tors against these alterations. Retinal vascular leakage was assessed by dextran fluorescence angiography. Retinal thickness and vascular leakage were increased 2 and 4 weeks after onset of diabetes, respectively. Immuno-staining showed that morphological change of microglia (amoeboid form) was observed at 2 weeks. Subsequently, increased angiopoietin-2 expression, simultaneous loss of pericytes and endothelial cells, decreased vessel den-sity, retinal hypoxia, and increased vascular endothelial growth factor (VEGF)-A/VEGF receptor system occurred at 4 weeks. SGLT2 inhibitors (luseogliflozin and ipragliflo-zin) had a significant protective effect on retinal vascular leakage and retinal thickness at a low dose that did not show glucose-lowering effects. Furthermore, both inhibitors at this dose attenuated microglia morphological changes and these early pathogenic alterations in DR. In vitro study showed both inhibitors attenuated the lipopolysaccharide-induced activation of primary microglia, along with morphological changes toward an inactive form, suggesting the di-rect inhibitory effect of SGLT2 inhibitors on microglia. In summary, SGLT2 inhibitors may directly prevent early pathogenic mechanisms, thereby potentially playing a role in pre-venting DR.

    DOI: 10.2337/db22-0970

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  • Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases

    Mori, R; Abe, M; Saimoto, Y; Shinto, S; Jodai, S; Tomomatsu, M; Tazoe, K; Ishida, M; Enoki, M; Kato, N; Yamashita, T; Itabashi, Y; Nakanishi, I; Ohkubo, K; Kaidzu, S; Tanito, M; Matsuoka, Y; Morimoto, K; Yamada, KI

    REDOX BIOLOGY   73   103186   2024.7   ISSN:2213-2317

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    Language:English   Publisher:Redox Biology  

    Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting oxidized lipids, particularly lipid-derived radicals critical in lipid peroxidation, which are known as radical-trapping antioxidants (RTAs), have been actively pursued. We focused our investigation on nitroxide compounds that have rapid second-order reaction rate constants for reaction with lipid-derived radicals. A novel screening system was developed by employing competitive reactions between library compounds and a newly developed profluorescence nitroxide probe with lipid-derived radicals to identify RTA compounds. A PubMed search of the top hit compounds revealed their wide application as repositioned drugs. Notably, the inhibitory efficacy of methyldopa, selected from these compounds, against retinal damage and bilateral common carotid artery stenosis was confirmed in animal models. These findings underscore the efficacy of our screening system and suggest that it is an effective approach for the discovery of RTA compounds.

    DOI: 10.1016/j.redox.2024.103186

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  • Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

    Yamada, N; Karasawa, T; Ito, J; Yamamuro, D; Morimoto, K; Nakamura, T; Komada, T; Baatarjav, C; Saimoto, Y; Jinnouchi, Y; Watanabe, K; Miura, K; Yahagi, N; Nakagawa, K; Matsumura, T; Yamada, KI; Ishibashi, S; Sata, N; Conrad, M; Takahashi, M

    NATURE COMMUNICATIONS   15 ( 1 )   2195   2024.3   eISSN:2041-1723

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    Language:English   Publisher:Nature Communications  

    Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme of cholesterol biosynthesis, as a regulator of ferroptosis in hepatocytes. Genetic and pharmacological inhibition (with AY9944) of DHCR7 suppress ferroptosis in human hepatocellular carcinoma Huh-7 cells. DHCR7 inhibition increases its substrate, 7-dehydrocholesterol (7-DHC). Furthermore, exogenous 7-DHC supplementation using hydroxypropyl β-cyclodextrin suppresses ferroptosis. A 7-DHC-derived oxysterol metabolite, 3β,5α-dihydroxycholest-7-en-6-one (DHCEO), is increased by the ferroptosis-inducer RSL-3 in DHCR7-deficient cells, suggesting that the ferroptosis-suppressive effect of DHCR7 inhibition is associated with the oxidation of 7-DHC. Electron spin resonance analysis reveals that 7-DHC functions as a radical trapping agent, thus protecting cells from ferroptosis. We further show that AY9944 inhibits hepatic ischemia-reperfusion injury, and genetic ablation of Dhcr7 prevents acetaminophen-induced acute liver failure in mice. These findings provide new insights into the regulatory mechanism of liver ferroptosis and suggest a potential therapeutic option for ferroptosis-related liver diseases.

    DOI: 10.1038/s41467-024-46386-6

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  • Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in <i>Akr1a</i>-Knockout Mice

    Bo, T; Nohara, H; Yamada, KI; Miyata, S; Fujii, J

    ANTIOXIDANTS   13 ( 2 )   2024.2   ISSN:2076-3921 eISSN:2076-3921

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    Language:English   Publisher:Antioxidants  

    Bone marrow cells are the most sensitive to exposure to X-rays in the body and are selectively damaged even by doses that are generally considered permissive in other organs. Ascorbic acid (Asc) is a potent antioxidant that is reported to alleviate damages caused by X-ray exposure. However, rodents can synthesize Asc, which creates difficulties in rigorously assessing its effects in such laboratory animals. To address this issue, we employed mice with defects in their ability to synthesize Asc due to a genetic ablation of aldehyde reductase (Akr1a-KO). In this study, concentrations of white blood cells (WBCs) were decreased 3 days after exposure to X-rays at 2 Gy and then gradually recovered. At approximately one month, the recovery rate of WBCs was delayed in the Akr1a-KO mouse group, which was reversed via supplementation with Asc. Following exposure to X-rays, Asc levels decreased in plasma, bone marrow cells, and the liver during an early period, and then started to increase. X-ray exposure stimulated the pituitary gland to release adrenocorticotropic hormone (ACTH), which stimulated corticosterone secretion. Asc released from the liver, which was also stimulated by ACTH, appeared to be recruited to the bone marrow. Since corticosterone in high doses is injurious, these collective results imply that Asc protects bone marrow via its antioxidant capacity against ROS produced via exposure to X-rays and the cytotoxic action of transiently elevated corticosterone.

    DOI: 10.3390/antiox13020152

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  • Co-expression of regulatory B-cell markers, transforming growth factor β and interleukin-10 as a prognostic factor in diffuse large B-cell lymphoma

    Mishina, T; Miyoshi, H; Takeuchi, M; Miyawaki, K; Nakashima, K; Yamada, K; Moritsubo, M; Inoue-Mitsuyama, K; Shimasaki, Y; Imamoto, T; Kawamoto, K; Furuta, T; Kohno, K; Kato, K; Akashi, K; Ohshima, K

    PATHOLOGY RESEARCH AND PRACTICE   254   155117   2024.2   ISSN:0344-0338 eISSN:1618-0631

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  • Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation Reviewed International journal

    Tsuruta K, Matsuoka M, Harada S, Enomoto A, Kumagai T, Yasuda S, Koumura T, Yamada KI, Imai H

    J Clin Biochem.   74 ( 2 )   97 - 107   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3164/jcbn.23-101

  • Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A Reviewed International journal

    Ishimaru K, Ikeda M, Miyamoto HD, Furusawa S, Abe K, Watanabe M, Kanamura T, Fujita S, Nishimura R, Toyohara T, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H, Ide T

    J Am Heart Assoc.   13 ( 1 )   e031219   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1161/JAHA.123.031219

  • Ethoxyquin, a Lipid Peroxidation Inhibitor, Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion Reviewed International journal

    Abe M, Sou M, Matsuoka Y, Morimoto K, Yamada KI

    Biol Pharm Bull.   13 ( 1 )   e031219   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1248/bpb.b23-00538

  • Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice Reviewed International journal

    Bo T, Nohara H, Yamada K, Miyata S, Fujii J

    Antioxidants.   13 ( 2 )   152   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3390/antiox13020152

  • Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis Reviewed International journal

    Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M

    Nat Commun.   15 ( 1 )   2195   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41467-024-46386-6.

  • Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells Reviewed International journal

    Tomomatsu M, Imamura N, Izumi H, Watanabe M, Ikeda M, Ide T, Uchinomiya S, Ojida A, Jutanom M, Morimoto K, Yamada KI

    Biol Pharm Bull.   47 ( 3 )   641 - 651   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1248/bpb.b23-00849

  • MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion Reviewed International journal

    Ichihara G, Katsumata Y, Sugiura Y, Matsuoka Y, Maeda R, Endo J, Anzai A, Shirakawa K, Moriyama H, Kitakata H, Hiraide T, Goto S, Ko S, Iwasawa Y, Sugai K, Daigo K, Goto S, Sato K, Yamada KI, Suematsu M, Ieda M, Sano M

    Circ Res.   133 ( 10 )   861 - 876   2023.10

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    DOI: doi: 10.1161/CIRCRESAHA.123.323517

  • Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage Reviewed International journal

    Fujii J, Yamada KI

    Free Radic Res.   57 ( 5 )   353 - 372   2023.4

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    DOI: doi: 10.1080/10715762.2023.2244155

  • Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity Reviewed International journal

    Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H

    JCI Insight.   8 ( 6 )   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1172/jci.insight.169756

  • マウスにおけるX線および炭素線照射の生物学的影響に対するセレン欠乏の影響(Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice)

    Ueno Megumi, Shibata Sayaka, Nakanishi Ikuo, Aoki Ichio, Yamada Ken-ichi, Matsumoto Ken-ichiro

    Journal of Clinical Biochemistry and Nutrition   72 ( 2 )   107 - 116   2023.3   ISSN:0912-0009

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    Language:English   Publisher:(一社)日本酸化ストレス学会  

    トルラ酵母をベースとしたセレン(Se)欠乏食と純水を与えて作成したSe欠乏(SeD)マウスと正常マウスに、X線または炭素線を全身(5.6Gy)、後肢または頭部に照射し、30日生存率、後肢短縮およびMRIでの脳レドックス状態を比較した。X線および炭素線を全身照射後の30日死亡率は、正常マウスよりSeDマウスで高かったが、SeDマウスの死亡率についてX線と炭素線の差はなかった。SeDにて炭素線照射後の最大後肢短縮レベルに影響はなかったが、短縮速度が遅くなった。SeDは脳レドックス状態の変動に影響を与えなかった。Seを活性中心とするグルタチオンペルオキシダーゼは、ミトコンドリアの呼吸から生じる内因性の過酸化水素を処理するが、放射線照射により生じるH2O2を分解する能力はないと考えられた。

  • Structural Analysis of Intracellular Lipid Radicals by LC/MS/MS Using a BODIPY-Based Profluorescent Nitroxide Probe Reviewed International journal

    Anal Chem.   14 ( 95(10) )   4585 - 4591   2023.2   ISSN:0003-2700 eISSN:1520-6882

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.analchem.2c04950

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  • Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis Reviewed International journal

    Redox Ex Med.   2023 ( 1 )   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1530/REM-22-0024

  • Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity Reviewed International journal

    Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.

    J Cardiovasc Pharmacol.   1:80 ( 5 )   690 - 699   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/FJC.0000000000001328.

  • Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis Reviewed International journal

    Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.

    Sci Signal.   15 ( 758 )   eabn801   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.abn8017.

  • Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity Reviewed International journal

    Ueno M, Shibata S, Nakanishi I, Aoki I, Yamada KI, Matsumoto KI

    J Clin Biochem Nutr.   72 ( 2 )   107 - 116   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s12276-022-00888-9

  • SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice Reviewed International journal

    54 ( 11 )   2036 - 2046   2022.10

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    DOI: doi: 10.1038/s12276-022-00888-9

  • A non-canonical vitamin K cycle is a potent ferroptosis suppressor Reviewed International journal

    Nature   608 ( 7924 )   778 - 783   2022.8

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  • Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol. Reviewed International journal

    ( 154 )   113624   2022.8

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    Vascular complications in β-thalassemia are associated with oxidative modification of lipoproteins under high oxidative stress. The lipid components of lipoproteins are oxidized via lipid peroxidation and produce lipid radicals (L•) as the key initial intermediates. Modification of lipid components, therefore, might result in alterations in the rate and products of lipid peroxidation. In this study, the kinetics of L• formation during the 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH)- and hemin-induced oxidation of low-density and high-density lipoproteins (LDL and HDL) from β-thalassemia patients and healthy volunteers were investigated using a specific and sensitive fluorescence probe for L•. Kinetic parameters, including initial lag time, propagation rate and total L• production, were calculated by monitoring a fluorescence-active NBD-Pen-L• adduct. Oxidation of thalassemia lipoproteins exhibited a significantly shorter lag time but a slower propagation rate of L• formation when compared with healthy lipoproteins. LDL showed higher resistance to oxidation during the initiation phase but higher L• formation than HDL. Our results indicated that the levels of α-tocopherol determined the initial lag time, whereas the levels of core lipids and cholesteryl esters, especially cholesteryl linoleate (CL), determined the propagation rate and total L• production. The difference in potency of AAPH and hemin supported that hemin preferentially targeted core lipids. Moreover, analysis of 13-hydroxyoctadecadienoic acid cholesteryl ester (13-HODE-CE)/CE ratio indicated that thalassemia lipoproteins have higher susceptibility to oxidation than healthy lipoproteins. In conclusion, our findings suggested that CL and α-tocopherol were implicated in the susceptibility of lipoproteins to lipid peroxidation in physiological and pathological conditions of β-thalassemia.

  • Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury Reviewed International journal

    JACC Basic Transl Sci .   27 ( 7(8) )   800 - 819   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jacbts.2022.03.012.

  • Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe Reviewed International journal

    Chem Commun.   ( 58 )   56 - 59   2021.12

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  • Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques Reviewed International journal

    Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada KI.

    Nat Commun.   12   6339   2021.11

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    Language:English  

    Repository Public URL: https://hdl.handle.net/2324/7172670

  • Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol Reviewed International journal

    25 ( 4(1) )   796   2021.6

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    Language:English  

    Mammalian hibernators endure severe and prolonged hypothermia that is lethal to non-hibernators, including humans and mice. The mechanisms responsible for the cold resistance remain poorly understood. Here, we found that hepatocytes from a mammalian hibernator, the Syrian hamster, exhibited remarkable resistance to prolonged cold culture, whereas murine hepatocytes underwent cold-induced cell death that fulfills the hallmarks of ferroptosis such as necrotic morphology, lipid peroxidation and prevention by an iron chelator. Unexpectedly, hepatocytes from Syrian hamsters exerted resistance to cold- and drug-induced ferroptosis in a diet-dependent manner, with the aid of their superior ability to retain dietary α-tocopherol (αT), a vitamin E analog, in the liver and blood compared with those of mice. The liver phospholipid composition is less susceptible to peroxidation in Syrian hamsters than in mice. Altogether, the cold resistance of the hibernator’s liver is established by the ability to utilize αT effectively to prevent lipid peroxidation and ferroptosis.

    DOI: 10.1038/s42003-021-02297-6.

  • Detection and structural analysis of lipid-derived radicals in vitro and in vivo. Reviewed International journal

    @Matsuoka Y, @Yamada KI

    Free Radic Res   8 ( 1-9 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/10715762.2021.1881500

  • Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels Reviewed International journal

    Ishii N, Homma T, Takeda Y, Aung NY, Yamada KI, Miyata S, Asao H, Yamakawa M, Fujii J

    J Nutr Biochem   91 ( 108604 )   2021.2

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    DOI: 10.1016/j.jnutbio.2021.108604

  • A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals. International journal

    Risa Azuma, Toshihide Yamasaki, Kohei Sano, Masayuki Munekane, Yuta Matsuoka, Ken-Ichi Yamada, Takahiro Mukai

    Free radical biology & medicine   163   297 - 305   2021.2

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    DOI: 10.1016/j.freeradbiomed.2020.12.028

  • Push-Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity-Induced Aggregation and Crystallization-Induced Emission Enhancement and Fluorescence Resonance Energy Transfer Reviewed International journal

    Hagihara R, Umeno T, Ueki S, Yoshihara D, Fuchi Y, Usui K, Sakuma M, Yamada KI, Karasawa S

    Chemistry   27 ( 9 )   3039 - 3046   2021.2

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    DOI: 10.1002/chem.202003854

  • Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue. International journal

    Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-Ichi Yamada, Satoshi Miyata, Hironobu Asao, Kaoru Goto, Tetsu Watanabe, Masafumi Watanabe, Shinya Toyokuni, Junichi Fujii

    Free radical biology & medicine   162   255 - 265   2021.1

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    DOI: 10.1016/j.freeradbiomed.2020.10.023

  • Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice. Reviewed International journal

    Moon G, Kobayashi S, Aung Naing Y, Yamada KI, Yamakawa M, Fujii J

    Free Radic Res   54 ( 8-9 )   606 - 619   2020.9

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    DOI: 10.1080/10715762.2020.1819996.

  • Method for Structural Determination of Lipid-Derived Radicals. International journal

    Yuta Matsuoka, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Ken-Ichi Yamada

    Analytical chemistry   92 ( 10 )   6993 - 7002   2020.5

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    DOI: 10.1021/acs.analchem.0c00053

  • Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach Reviewed

    Ryoma Shiraishi, Shota Matsumoto, Yasufumi Fuchi, Tatsuya Naganuma, Daisuke Yoshihara, Kazuteru Usui, Ken Ichi Yamada, Satoru Karasawa

    Langmuir   36 ( 19 )   5280 - 5286   2020.5

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    DOI: 10.1021/acs.langmuir.0c00610

  • Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. Reviewed

    Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, Hiroko Deguchi, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui

    JCI Insight.   249   2020.5

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    DOI: 10.1172/jci.insight.132747

  • Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway. International journal

    249   117501 - 117501   2020.5

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    AIMS: Aldehyde reductase (AKR1A) is involved in the synthesis of ascorbic acid (AsA) as well as the detoxification of aldehydes. AKR1A-/- (KO) mice produce about 10&#37; of the normal amounts of AsA compared to AKR1A+/+ (WT) mice. We investigated physiologic roles of AKR1A in running using the KO mice. MAIN METHODS: The KO mice were subjected to a treadmill test under either restricted AsA production or a sufficiency by supplementation and compared the results with those of WT mice. Contents of glucose, aspartate aminotransferase, AsA and free fatty acids in blood were measured. Glycogen contents were measured in the liver and skeletal muscle, and hepatic proteins were examined by immunoblot analyses. KEY FINDINGS: Running performance was higher in the KO mice than the WT mice irrespective of the AsA status. After the exercise period, blood glucose levels were decreased in the WT mice but were preserved in the KO mice. Liver glycogen levels were also consistently preserved in the KO mice after exercise. Free fatty acid levels tended to be originally high in blood plasma compared to those of the WT mice and were increased to similar extent in them. A key regulator of energy metabolism, PGC-1α, and the products of downstream target genes that encode for glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphatase, were constitutively at high levels in the KO mice. SIGNIFICANCE: The genetic ablation of AKR1A activates the PGC-1α pathway and spare glucose, which would consequently confer exercise endurance.

    DOI: 10.1016/j.lfs.2020.117501

  • Reaction targets of antioxidants in azo-initiator or lipid hydroperoxide induced lipid peroxidation. International journal

    Kota Saito, Yuta Matsuoka, Ken-Ichi Yamada

    Free radical research   54 ( 5 )   301 - 310   2020.5

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    DOI: 10.1080/10715762.2020.1761020

  • Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach Reviewed International journal

    Shiraishi R, Matsumoto S, Fuchi Y, Naganuma T, Yoshihara D, Usui K, Yamada KI, Karasawa S.

    Langmuir.   36 ( 19 )   5280 - 5286   2020.4

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    DOI: 10.1021/acs.langmuir.0c00610

  • Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals. International journal

    Toshihide Yamasaki, Risa Azuma, Kohei Sano, Masayuki Munekane, Yuta Matsuoka, Ken-Ichi Yamada, Takahiro Mukai

    ACS medicinal chemistry letters   11 ( 1 )   45 - 48   2020.1

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    DOI: 10.1021/acsmedchemlett.9b00416

  • Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents Reviewed International journal

    Ryoma Shiraishi, Tomoyo Kaneko, Kazuteru Usui, Tatsuya Naganuma, Naoko Iizuka, Kosuke Morishita, Shigeki Kobayashi, Yasufumi Fuchi, Yuta Matsuoka, Go Hirai, Ken-Ichi Yamada, Satoru Karasawa

    ACS Omega   4 ( 24 )   20715 - 20723   2019.12

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    DOI: 10.1021/acsomega.9b03003

  • Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers Reviewed International journal

    Mishima E, Sato E, Ito J, Yamada KI, Suzuki C, Oikawa Y, Matsuhashi T, Kikuchi K, Toyohara T, Suzuki T, Ito S, Nakagawa K, Abe T.

    J Am Soc Nephrol   31 ( 2 )   280 - 296   2019.11

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    DOI: 10.1681/ASN.2019060570

  • Radiation-induced redox alteration in the mouse brain. Reviewed International journal

    Mizuki Nakamura, Toshihide Yamasaki, Megumi Ueno, Sayaka Shibata, Yoshikazu Ozawa, Tadashi Kamada, Ikuo Nakanishi, Ken-Ichi Yamada, Ichio Aoki, Ken-Ichiro Matsumoto

    Free radical biology & medicine   143   412 - 421   2019.11

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    DOI: 10.1016/j.freeradbiomed.2019.08.020

  • Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice. Reviewed

    Kurihara, K, Homma T, Kobayashi S, Shichiri M, Fujiwara H, Fujii S, Yamada KI, Nakane M, Kawamae K, Fujii J.

    J Clin Biochem Nutr   65 ( 2 )   1 - 8   2019.8

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    DOI: 10.3164/jcbn.19-41

  • Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice. Reviewed

    Ishii N, Homma T, Lee J, Mitsuhashi H, Yamada KI, Kimura N, Yamamoto Y, Fujii J.

    Biol Reprod.   149   1 - 14   2019.8

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    DOI: 10.1093/biolre/ioz149.

  • Kinetics and localization of hemin-induced lipoprotein oxidation Reviewed International journal

    Noppawan Phumala Morales, Pacharaporn Chunephisal, Jindaporn Janprasit, Yuma Ishida, Rataya Leuchapudiporn, Ken-Ichi Yamada

    Free Radical Research   2019.8

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    DOI: 10.1080/10715762.2019.1660323

  • In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. International journal

    Keiji Yasukawa, Ryota Shigemi, Tomomi Kanbe, Yusaku Mutsumoto, Fumiko Oda, Kazuhiro Ichikawa, Ken-Ichi Yamada, Xin Tun, Hideo Utsumi

    Antioxidants & redox signaling   30 ( 9 )   1147 - 1161   2019.3

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    DOI: 10.1089/ars.2017.7336

  • 2-Oxo-histidine-containing dipeptides are functional oxidation products. Reviewed International journal

    Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamada KI, Uchida K.

    J Biol Chem.   25 ( 294(4) )   1279 - 1289   2019.1

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    DOI: 10.1074/jbc.RA118.006111.

  • Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model. Invited Reviewed

    Emoto MC, Sato-Akaba H, Matsuoka Y, Yamada KI, Fujii HG

    Neuroscience letters   690   6 - 10   2018.10

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    Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model.

    DOI: 10.1016/j.neulet.2018.10.001

    Other Link: 10.1016/j.neulet.2018.10.001

  • Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative. Reviewed

    Araki T, Fuchi Y, Murayama S, Shiraishi R, Oyama T, Aso M, Aoki I, Kobayashi S, Yamada KI, Karasawa S

    Nanomaterials (Basel, Switzerland)   8 ( 10 )   2018.10

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    Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative.

    DOI: 10.3390/nano8100782

  • Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury. Reviewed International journal

    Takujiro Homma, Takaya Shirato, Ryusuke Akihara, Sho Kobayashi, Jaeyong Lee, Ken-Ichi Yamada, Satoshi Miyata, Motoko Takahashi, Junichi Fujii

    Toxicology letters   294   37 - 43   2018.9

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    DOI: 10.1016/j.toxlet.2018.05.015

  • Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells Reviewed

    Yamamoto Kumiko, Yasui Hironobu, Bo Tomoki, Yamamori Tohru, Hiraoka Wakako, Yamasaki Toshihide, Yamada Ken-ichi, Inanami Osamu

    APPLIED MAGNETIC RESONANCE   49 ( 8 )   837 - 851   2018.8

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    Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

    DOI: 10.1007/s00723-018-1007-0

  • Recent Developments in Electron Spin Science and Technology in Japan Reviewed

    Toshikazu Nakamura, Tadaaki Ikoma, Ken-Ichi Yamada

    Applied Magnetic Resonance   49 ( 8 )   755 - 756   2018.8

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    DOI: 10.1007/s00723-018-1035-9

  • Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson's disease animal model. Reviewed International journal

    Fujita A, Yamaguchi H, Yamasaki R, Cui Y, Matsuoka Y, Yamada KI, Kira JI

    Journal of neuroinflammation   15 ( 1 )   227 - 227   2018.8

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    Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson's disease animal model.
    BACKGROUND: The first pathology observed in Parkinson's disease (PD) is 'dying back' of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration remain elusive. We investigated Cx30 function in an acute PD model by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to wild-type (WT) and Cx30 knockout (KO) mice. METHODS: On days 1 and 7 after MPTP administration, we evaluated changes in astrocytic Cx30, Cx43, glial fibrillary acidic protein, and ionised calcium-binding adapter molecule 1 expression by immunostaining and biochemical analysis. Loss of DA neurons was evaluated by tyrosine hydroxylase immunostaining. Gene expression was analysed using A1, A2, pan-reactive astrocyte microarray gene sets, and M1, M2, and M1/M2 mixed microglial microarray gene sets. Real-time PCR and in situ hybridisation were performed to evaluate glial cell-derived neurotrophic factor (Gdnf) and S100a10 expression. Striatal GDNF protein levels were determined by enzyme-linked immunosorbent assay. RESULTS: MPTP treatment induced upregulation of Cx30 and Cx43 levels in the striatum of WT and KO mice. DA neuron loss was accelerated in Cx30 KO compared with WT mice after MPTP administration, despite no change in the striatal concentration of methyl-4-phenylpyridinium+. Astrogliosis in the striatum of Cx30 KO mice was attenuated by MPTP, whereas microglial activation was unaffected. Microarrays of the striatum showed reduced expression of pan-reactive and A2 astrocyte genes after MPTP treatment in Cx30 KO compared with WT mice, while M1, M2, and M1/M2 mixed microglial gene expression did not change. MPTP reduced the number of striatal astrocytes co-expressing Gdnf mRNA and S100β protein or S100a10 mRNA and S100β protein and also reduced the level of GDNF in the striatum of Cx30 KO compared with WT mice. CONCLUSIONS: These findings indicate that Cx30 plays critical roles in astrocyte neuroprotection in an MPTP PD model.

    DOI: 10.1186/s12974-018-1251-0

  • Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells Invited Reviewed

    Yamamoto K, Yasui H, Bo T, Yamamori T, Hiraoka W, Yamasaki T, Yamada KI, Inanami O

    Applied Magnetic Resonance   49 ( 8 )   837 - 851   2018.7

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    Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

    DOI: 10.1007/s00723-018-1007-0

  • Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice Reviewed

    Nao Kato, Suguru Sato, Ken-Ichi Yamada, Kazuhiro Ichikawa

    Applied Magnetic Resonance   1 - 11   2018.4

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    DOI: 10.1007/s00723-018-1004-3

  • Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death Reviewed

    Saki Shinto, Yuta Matsuoka, Mayumi Yamato, Ken-Ichi Yamada

    Journal of Clinical Biochemistry and Nutrition   62 ( 2 )   132 - 138   2018.3

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    DOI: 10.3164/jcbn.17-60

  • Nitric oxide is involved in activation of Toll-like receptor 4 signaling through tyrosine nitration of Src homology protein tyrosine phosphatase 2 in murine dextran sulfate-induced colitis Reviewed

    Xin Tun, Keiji Yasukawa, Ken-Ichi Yamada

    Biological and Pharmaceutical Bulletin   41 ( 12 )   1843 - 1852   2018.1

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    DOI: 10.1248/bpb.b18-00558

  • Detection and inhibition of lipid-derived radicals in low-density lipoprotein Reviewed

    Yuma Ishida, Yuka Okamoto, Yuta Matsuoka, Arisa Tada, Jindaporn Janprasit, Mayumi Yamato, Noppawan Phumala Morales, Ken-Ichi Yamada

    FREE RADICAL BIOLOGY AND MEDICINE   113   487 - 493   2017.12

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    DOI: 10.1016/j.freeradbiomed.2017.10.388

  • Feasibility of Magnetic Resonance Redox Imaging at Low Magnetic Field: Comparison at 1 T and 7 T Reviewed

    Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto K, Kamada T, Yamada K, Aoki I

    American Journal of Translational Research   9 ( 10 )   4481 - 4491   2017.10

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    Feasibility of Magnetic Resonance Redox Imaging at Low Magnetic Field: Comparison at 1 T and 7 T
    The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T-1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T-1-weighted images and susceptibility of T-1-weighted signals were compared. The nitroxyl radical-based T-1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T-1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T-1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.

  • Lipid radicals cause light-induced retinal degeneration Reviewed International journal

    Enoki M, Shinto S, Matsuoka Yuta, Otsuka A, Kaidzu S, Tanito M, Shibata T, Ohira A, Yamato Mayumi, Ken-ichi Yamada

    53   10922 - 10925   2017.9

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    DOI: 10.1039/c7cc03387g.

  • Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells Reviewed

    Hironobu Yasui, Kumiko Yamamoto, Motofumi Suzuki, Yuri Sakai, Tomoki Bo, Masaki Nagane, Eri Nishimura, Tohru Yamamori, Toshihide Yamasaki, Ken-ichi Yamada, Osamu Inanami

    CANCER LETTERS   390 ( 390 )   160 - 167   2017.4

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    DOI: 10.1016/j.canlet.2017.01.006

  • Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging Reviewed

    Miho C. Emoto, Yuta Matsuoka, Ken-ichi Yamada, Hideo Sato-Akaba, Hirotada G. Fujii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   485 ( 4 )   802 - 806   2017.4

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    DOI: 10.1016/j.bbrc.2017.02.134

  • Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a) Reviewed

    Takujiro Homma, Ryusuke Akihara, Satoshi Okano, Mototada Shichiri, Yasukazu Yoshida, Ken-ichi Yamada, Satoshi Miyata, Osamu Nakajima, Junichi Fujii

    BEHAVIOURAL BRAIN RESEARCH   319 ( 319 )   219 - 224   2017.2

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    DOI: 10.1016/j.bbr.2016.11.038

  • Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells Reviewed International journal

    1016 ( 390 )   160 - 167   2017.1

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    DOI: 10

    Other Link: http://www.sciencedirect.com/science/article/pii/S0304383517300289

  • Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress. Reviewed

    Akihara R, Homma T, Lee J, Yamada K, Miyata S, Fujii J

    Biochemical and biophysical research communications   478 ( 2 )   765 - 771   2016.9

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    Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.

    DOI: 10.1016/j.bbrc.2016.08.022

  • Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging Reviewed

    Ken-ichiro Matsumoto, Toshihide Yamasaki, Mizuki Nakamura, Junji Ishikawa, Megumi Ueno, Ikuo Nakanishi, Aiko Sekita, Yoshikazu Ozawa, Tadashi Kamada, Ichio Aoki, Ken-ichi Yamada

    MAGNETIC RESONANCE IN MEDICINE   76 ( 3 )   935 - 945   2016.9

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    DOI: 10.1002/mrm.25918

  • Fluorescence probes to detect lipid-derived radicals Reviewed

    Ken-ichi Yamada, Fumiya Mito, Yuta Matsuoka, Satsuki Ide, Kazushige Shikimachi, Ayano Fujiki, Daiki Kusakabe, Yuma Ishida, Masataka Enoki, Arisa Tada, Miyuki Ariyoshi, Toshihide Yamasaki, Mayumi Yamato

    Nature Chemical Biology   12 ( 8 )   608 - +   2016.8

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    DOI: 10.1038/NCHEMBIO.2105

  • TEMPOL increases NAD(+) and improves redox imbalance in obese mice Reviewed

    Mayumi Yamato, Kimika Kawano, Yuki Yamanaka, Misako Saiga, Ken-ichi Yamada

    REDOX BIOLOGY   8 ( 8 )   316 - 322   2016.8

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    DOI: 10.1016/j.redox.2016.02.007

  • Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy Reviewed

    Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Takujiro Homma, Eun Sil Kang, Yuka Saito, Sohsuke Yamada, Toshiyuki Nakayama, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   604 ( 604 )   36 - 46   2016.8

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    DOI: 10.1016/j.abb.2016.06.004

  • A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma Reviewed International journal

    Matsuoka Y, Ohkubo K, Yamazaki T, Yamato M, Ohtabu H, Shirouzu T, Fukuzumi S, Ken-ichi Yamada

    58 ( 1 )   16 - 22   2016.6

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    DOI: 10

  • Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy Reviewed International journal

    Kurahashi T, Lee J, Nabeshima A, Homma T, Kang ES, Saito Y, Yamada S, Nakayama T, Ken-ichi Yamada, Miyata S, Fujii J

    ( 604 )   36 - 46   2016.6

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    DOI: 10

  • A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats Reviewed

    Shinichiro Kimura, Toyoshi Inoguchi, Toshihide Yamasaki, Mayumi Yamato, Makoto Ide, Noriyuki Sonoda, Kenichi Yamada, Ryoichi Takayanagi

    METABOLISM-CLINICAL AND EXPERIMENTAL   65 ( 3 )   138 - 145   2016.3

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    DOI: 10.1016/j.metabol.2015.10.030

  • Photodecomposition of tetrabromobisphenol A in aqueous humic acid suspension by irradiation with light of various wavelengths Reviewed

    Sang Kuk Han, Toshihide Yamasaki, Ken-ichi Yamada

    CHEMOSPHERE   147 ( 147 )   124 - 130   2016.3

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    DOI: 10.1016/j.chemosphere.2015.12.072

  • TEMPOL increases NAD+ and improves redox imbalance in obese mice. Reviewed International journal

    Yamato M, Kawano K, Yamanaka Y, Saiga M, Ken-ichi Yamada

    8   316 - 322   2016.2

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    DOI: 10

  • Fluorescence probe for the convenient and sensitive detection of ascorbic acid Reviewed

    Yuta Matsuoka, Mayumi Yamato, Ken-ichi Yamada

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   58 ( 1 )   16 - 22   2016.1

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    DOI: 10.3164/jcbn.15-105

  • Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe Reviewed

    Miho C. Emoto, Mayumi Yamato, Hideo Sato-Akaba, Ken-ichi Yamada, Hirotada G. Fujii

    NEUROSCIENCE LETTERS   608 ( 608 )   40 - 44   2015.11

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    DOI: 10.1016/j.neulet.2015.10.008

  • Brain Contrasting Ability of Blood-Brain-Barrier- Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging Reviewed International journal

    Matsumoto T, Yamasaki T, Nakamura M, Ueno M, Nakanishi I, Shibata S, Sekita A, Saga T, Kamada T, Ken-ichi Yamada, Aoki I

    2015.9

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  • Brain Imaging in Methamphetamine-Treated Mice using a Nitroxide Contrast Agent for EPR Imaging of the Redox Status and a Gadolinium Contrast Agent for MRI Observation of Blood-Brain Barrier Function Reviewed International journal

    Emoto MC, Yamato Mayumi, Akaba-Sato H, Ken-ichi Yamada, Matsuoka Y, Fujii HG

    49 ( 8 )   1038 - 1047   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress Reviewed

    Masataka Ikeda, Tomomi Ide, Takeo Fujino, Shinobu Arai, Keita Saku, Takamori Kakino, Henna Tyynismaa, Toshihide Yamasaki, Ken-ichi Yamada, Dongchon Kang, Anu Suomalainen, Kenji Sunagawa

    PLOS ONE   10 ( 3 )   2015.3

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    DOI: 10.1371/journal.pone.0119687

  • Diffusion studies of redox-sensitive nitroxyl spin probes through bilayer lipid membranes using 300 MHz electron spin resonance spectrometer

    A. M.F. Benial, M. K. Dhas, K. Ichikawa, K. Yamada, F. Hyodo, A. Jawahar, H. Utsumi

    Biofizika   60 ( 1 )   88 - 94   2015.1

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  • Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction Reviewed

    H. Nishida, T. Kurahashi, Y. Saito, N. Otsuki, M. Kwon, H. Ohtake, M. Yamakawa, K. -I. Yamada, S. Miyata, Y. Tomita, J. Fujii

    FREE RADICAL RESEARCH   48 ( 9 )   1115 - 1124   2014.9

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    DOI: 10.3109/10715762.2014.915031

  • Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. Reviewed International journal

    Toshihiro Kurahashi, Myoungsu Kwon, Takujiro Homma, Yuka Saito, Jaeyong Lee, Motoko Takahashi, Ken-Ichi Yamada, Satoshi Miyata, Junichi Fujii

    Biochemical and biophysical research communications   452 ( 1 )   136 - 41   2014.9

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    DOI: 10.1016/j.bbrc.2014.08.072

  • Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis Reviewed

    Xin Tun, Keiji Yasukawa, Ken-ichi Yamada

    FREE RADICAL BIOLOGY AND MEDICINE   74   108 - 117   2014.9

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    DOI: 10.1016/j.freeradbiomed.2014.06.020

  • Change in Overhauser Effect-enhanced MRI Signal in Response to uPA Highly Expressing in Tumor Reviewed

    Takuro Niidome, Nobukatsu Chijiiwa, Toshihide Yamasaki, Ken-ichi Yamada, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa, Yoshiki Katayama

    CHEMISTRY LETTERS   43 ( 7 )   999 - 1001   2014.7

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    DOI: 10.1246/cl.140209

  • Tempol intake improves inflammatory status in aged mice Reviewed

    Mayumi Yamato, Ayumi Ishimatsu, Yuuki Yamanaka, Takara Mine, Kenichi Yamada

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   55 ( 1 )   11 - 14   2014.7

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    DOI: 10.3164/jcbn.14-4

  • Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

    Tracey B Kajer, Kathryn E Fairfull-Smith, Toshihide Yamasaki, Ken-ichi Yamada, Shanlin Fu, Steven E Bottle, Clare L Hawkins, Michael J Davies

    FREE RADICAL BIOLOGY AND MEDICINE   70   2014.5

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    DOI: 10.1016/j.freeradbiomed.2014.02.011

  • Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice Reviewed

    Junitsu Ito, Noriyuki Otsuki, Xuhong Zhang, Tasuku Konno, Toshihiro Kurahashi, Motoko Takahashi, Mayumi Yamato, Yuta Matsuoka, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii

    LIFE SCIENCES   95 ( 1 )   1 - 8   2014.1

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    DOI: 10.1016/j.lfs.2013.12.004

  • Non-invasive Redox Imaging of Cisplatin-Induced Nephrotoxicity Using Overhauser-MRI Reviewed

    Hyodo Fuminori, Honda Yohei, Naganuma Tatsuya, Ichikawa Kazuhiro, Yamada Ken-ichi, Utsumi Hideo

    FREE RADICAL BIOLOGY AND MEDICINE   65   S126   2013.11

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    Non-invasive Redox Imaging of Cisplatin-Induced Nephrotoxicity Using Overhauser-MRI

    DOI: 10.1016/j.freeradbiomed.2013.10.707

  • A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease Reviewed

    Akane Hayashi, Naoya Matsunaga, Hiroyuki Okazaki, Keisuke Kakimoto, Yoshinori Kimura, Hiroki Azuma, Eriko Ikeda, Takeshi Shiba, Mayumi Yamato, Ken-ichi Yamada, Satoru Koyanagi, Shigehiro Ohdo

    NEUROMOLECULAR MEDICINE   15 ( 2 )   238 - 251   2013.6

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    DOI: 10.1007/s12017-012-8214-x

  • Novel ascorbic acid-resistive nitroxide in a lipid emulsion: an efficient brain imaging contrast agent for MRI of small rodents. Reviewed International journal

    Miho C Emoto, Ken-Ichi Yamada, Mayumi Yamato, Hirotada G Fujii

    Neuroscience letters   546   11 - 5   2013.6

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    DOI: 10.1016/j.neulet.2013.04.044

  • Redox Potential of Nitroxides is an Index to Evaluate Superoxide Dismutase Mimic Activity Reviewed

    Toshihide Yamasaki, Yuta Matsuoka, Fumiya Mito, Mayumi Yamato, Ken-ichi Yamada

    ASIAN JOURNAL OF ORGANIC CHEMISTRY   2 ( 5 )   388 - 391   2013.5

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    DOI: 10.1002/ajoc.201300011

  • Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer Reviewed

    A. Milton Franklin Benial, M. Kumara Dhas, Kazuhiro Ichikawa, Ken-ichi Yamada, Fuminori Hyodo, A. Jawahar, Hideo Utsumi

    APPLIED MAGNETIC RESONANCE   44 ( 4 )   439 - 447   2013.4

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    DOI: 10.1007/s00723-012-0383-0

  • Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch Reviewed

    Yuta Matsuoka, Mayumi Yamato, Toshihide Yamasaki, Fumiya Mito, Ken-ichi Yamada

    FREE RADICAL BIOLOGY AND MEDICINE   53 ( 11 )   2112 - 2118   2012.12

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    DOI: 10.1016/j.freeradbiomed.2012.09.032

  • The detrimental effect of nitric oxide on tissue is associated with inflammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis Reviewed

    Keiji Yasukawa, Hiroto Tokuda, Xin Tun, Hideo Utsumi, Ken-ichi Yamada

    FREE RADICAL RESEARCH   46 ( 12 )   1427 - 1436   2012.12

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    DOI: 10.3109/10715762.2012.732698

  • Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI Reviewed

    Nuttavut Kosem, Tatsuya Naganuma, Kazuhiro Ichikawa, Noppawan Phumala Morales, Keiji Yasukawa, Fuminori Hyodo, Ken-ichi Yamada, Hideo Utsumi

    FREE RADICAL BIOLOGY AND MEDICINE   53 ( 2 )   328 - 336   2012.7

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    DOI: 10.1016/j.freeradbiomed.2012.04.026

  • High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice Reviewed

    Mayumi Yamato, Takeshi Shiba, Tomomi Ide, Naoko Seri, Wataru Kudo, Makoto Ando, Ken-ichi Yamada, Shintaro Kinugawa, Hiroyuki Tsutsui

    MOLECULAR AND CELLULAR BIOCHEMISTRY   359 ( 1-2 )   161 - 167   2012.1

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    DOI: 10.1007/s11010-011-1010-3

  • A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse. Reviewed

    Emoto M, Mito F, Yamasaki T, Yamada K, Sato-Akaba H, Hirata H, Fujii H

    Free radical research   45 ( 11-12 )   1325 - 1332   2011.11

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    A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse.

    DOI: 10.3109/10715762.2011.618499

  • Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model Reviewed

    Mayumi Yamato, Takeshi Shiba, Tatsuya Naganuma, Kazuhiro Ichikawa, Hideo Utsumi, Ken-ichi Yamada

    NEUROCHEMISTRY INTERNATIONAL   59 ( 6 )   804 - 811   2011.11

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    DOI: 10.1016/j.neuint.2011.08.010

  • Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. Reviewed

    Deguchi H, Yasukawa K, Yamasaki T, Mito F, Kinoshita Y, Naganuma T, Sato S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada K

    Free radical biology & medicine   51 ( 9 )   1799 - 1805   2011.11

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    Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.

    DOI: 10.1016/j.freeradbiomed.2011.08.010

  • Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. Reviewed

    Mito F, Kitagawa K, Yamasaki T, Shirahama C, Oishi T, Ito Y, Yamato M, Yamada K

    Free radical research   45 ( 9 )   1103 - 1110   2011.9

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    Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch.

    DOI: 10.3109/10715762.2011.595410

  • In vivo imaging of mitochondrial function in methamphetamine-treated rats Reviewed

    Takeshi Shiba, Mayumi Yamato, Wataru Kudo, Toshiaki Watanabe, Hideo Utsumi, Ken-ichi Yamada

    NEUROIMAGE   57 ( 3 )   866 - 872   2011.8

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    DOI: 10.1016/j.neuroimage.2011.05.041

  • Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects. Reviewed

    Yamato M, Shiba T, Ide T, Honda Y, Yamada K, Tsutsui H

    Hypertension research : official journal of the Japanese Society of Hypertension   34   840 - 845   2011.7

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    Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects.

    DOI: 10.1038/hr.2011.51

  • Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical. Reviewed International journal

    2011.5

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  • Structural concept of nitroxide as a lipid peroxidation inhibitor. Reviewed International journal

    Yamasaki T, Ito Y, Mito F, Kitagawa K, Matsuoka Y, Yamato M, Yamada K

    The Journal of organic chemistry   76 ( 10 )   4144 - 4148   2011.5

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    Structural concept of nitroxide as a lipid peroxidation inhibitor.
    Nitroxides have antioxidative activities toward lipid peroxidation, but the influence of steric factors is not known. We synthesized alkyl-substituted nitroxides at the α-position of the N-O moiety to enhance lipophilicity and the bulk effect. There was good correlation between the IC(50) and lipophilicity (log P(o/w)) of nitroxides with use of the thiobarbituric acid-reactive substances (TBARS) assay. Furthermore, an inhibitory effect on the TBARS assay was dependent upon the number and length of alkyl groups, though nitroxides had almost identical lipophilicity.

    DOI: 10.1021/jo200361p

  • Structure-Reactivity Relationship of Piperidine Nitroxide: Electrochemical, ESR and Computational Studies Reviewed

    Toshihide Yamasaki, Fumiya Mito, Yuko Ito, Sokkar Pandian, Yuichi Kinoshita, Koji Nakano, Ramachandran Murugesan, Kiyoshi Sakai, Hideo Utsumi, Ken-ichi Yamada

    JOURNAL OF ORGANIC CHEMISTRY   76 ( 2 )   435 - 440   2011.1

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    DOI: 10.1021/jo101961m

  • In vivo evaluation of novel nitroxyl radicals with reduction stability. Reviewed

    Kinoshita Y, Yamada K, Yamasaki T, Mito F, Yamato M, Kosem N, Deguchi H, Shirahama C, Ito Y, Kitagawa K, Okukado N, Sakai K, Utsumi H

    Free radical biology & medicine   49 ( 11 )   1703 - 1709   2010.12

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    In vivo evaluation of novel nitroxyl radicals with reduction stability.

    DOI: 10.1016/j.freeradbiomed.2010.08.027

  • Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution Reviewed

    A. Milton Franklin Benial, Hideo Utsumi, Kazuhiro Ichikawa, Ramachandran Murugesan, Ken-ichi Yamada, Yuichi Kinoshita, Tatsuya Naganuma, Masahisa Kato

    Journal of Magnetic Resonance   204 ( 1 )   131 - 138   2010.5

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    DOI: 10.1016/j.jmr.2010.02.016

  • Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism. Reviewed International journal

    Yamato M, Kudo W, Shiba T, Yamada KI, Watanabe T, Utsumi H.

    Free Radic Res   44   2010.3

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  • Effective 2,6-substitution of piperidine nitroxyl radical by carbonyl compound

    Kiyoshi Sakai, Ken-ichi Yamada, Toshihide Yamasaki, Yuichi Kinoshita, Fumiya Mito, Hideo Utsumi

    TETRAHEDRON   66 ( 13 )   2311 - 2315   2010.3

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    DOI: 10.1016/j.tet.2010.02.004

  • Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging Reviewed

    Mayumi Yamato, Takeshi Shiba, Ken-ichi Yamada, Toshiaki Watanabe, Hideo Utsumi

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   29 ( 10 )   1655 - 1664   2009.10

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    DOI: 10.1038/jcbfm.2009.84

  • Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid. Reviewed

    Kinoshita Y, Yamada K, Yamasaki T, Sadasue H, Sakai K, Utsumi H

    Free radical research   43 ( 6 )   565 - 571   2009.6

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    Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid.

    DOI: 10.1080/10715760902914575

  • Separable detection of lipophilic- and hydrophilic- phase free radicals from the ESR spectrum of nitroxyl radical in transient MCAO mice. Reviewed International journal

    Yamato M, Shiba T, Yamada K, Watanabe T, Utsumi H.

    Free Radic Res   43   2009.6

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  • Synthesis of nitroxyl radicals for Overhauser-enhanced magnetic resonance imaging. Reviewed

    Yamada K, Kinoshita Y, Yamasaki T, Sadasue H, Mito F, Nagai M, Matsumoto S, Aso M, Suemune H, Sakai K, Utsumi H

    Archiv der Pharmazie   341 ( 9 )   548 - 553   2008.9

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    Synthesis of nitroxyl radicals for Overhauser-enhanced magnetic resonance imaging.

    DOI: 10.1002/ardp.200800053

  • Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microdialysis technique. Reviewed International journal

    Shiba T, Yamato M, Kudou W, Ichikawa K, Yamada K, Watanabe T, Utsumi H.

    J Pharm Sci   2008.9

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  • Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study Reviewed

    Wataru Kudo, Mayumi Yamato, Ken-Ichi Yamada, Yuichi Kinoshita, Takeshi Shiba, Toshiaki Watanabe, Hideo Utsumi

    FREE RADICAL RESEARCH   42 ( 5 )   505 - 512   2008.5

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    DOI: 10.1080/10715760802112809

  • [Detection of in-vivo free radical reaction using magnetic resonance].

    Ken-ichi Yamada, Kiyoshi Sakai, Hideo Utsumi

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   52 ( 13 Suppl )   1529 - 33   2007.10

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  • Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI. Reviewed

    Matsumoto S, Yamada K, Hirata H, Yasukawa K, Hyodo F, Ichikawa K, Utsumi H

    Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine   57   806 - 811   2007.4

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    Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI.

    DOI: 10.1002/mrm.21198

  • Are free radical reactions increased in the diabetic eye? Reviewed

    Mayumi Yamato, Shingo Matsumoto, Katsuaki Ura, Ken-Ichi Yamada, Tatsuya Naganuma, Toyoshi Inoguchi, Toshiaki Watanabe, Hideo Utsumi

    ANTIOXIDANTS & REDOX SIGNALING   9 ( 3 )   367 - 373   2007.3

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    DOI: 10.1089/ars.2006.1502

  • Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging Reviewed

    A. Milton Franklin Benial, Kazuhiro Ichikawa, Ramachandran Murugesan, Ken-ichi Yamada, Hideo Utsumi

    JOURNAL OF MAGNETIC RESONANCE   182 ( 2 )   273 - 282   2006.10

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    DOI: 10.1016/j.jmr.2006.06.025

  • Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique. Reviewed International journal

    Hyodo F, Yasukawa K, Yamada K, Utsumi H.

    Magn Reson Med   2006.10

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  • In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue Reviewed

    Ken-ichi Yamada, Ikuo Yamamiya, Hideo Utsumi

    Free Radical Biology and Medicine   40 ( 11 )   2040 - 2046   2006.6

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    DOI: 10.1016/j.freeradbiomed.2006.01.031

  • Enhanced intraarticular free radical reactions in adjuvant arthritis rats Reviewed

    Ken-Ichi Yamada, Toshitaka Nakamura, Hideo Utsumi

    Free Radical Research   40 ( 5 )   455 - 460   2006.5

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    DOI: 10.1080/10715760500440536

  • Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats Reviewed

    Hideo Utsumi, Keiji Yasukawa, Tetsuhiro Soeda, Ken-Ichi Yamada, Ryota Shigemi, Takashi Yao, Masazumi Tsuneyoshi

    Journal of Pharmacology and Experimental Therapeutics   317 ( 1 )   228 - 235   2006.4

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    DOI: 10.1124/jpet.105.095166

  • Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals Reviewed

    Hideo Utsumi, Ken-Ichi Yamada, Kazuhiro Ichikawa, Kiyoshi Sakai, Yuichi Kinoshita, Shingo Matsumoto, Mika Nagai

    Proceedings of the National Academy of Sciences of the United States of America   103 ( 5 )   1463 - 1468   2006.1

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    DOI: 10.1073/pnas.0510670103

  • Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt Reviewed

    M. Kaimul Ahsan, Hajime Nakamura, Masaki Tanito, Kenichi Yamada, Hideo Utsumi, Junji Yodoi

    Free Radical Biology and Medicine   39 ( 12 )   1549 - 1559   2005.12

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    DOI: 10.1016/j.freeradbiomed.2005.07.016

  • In vivo EPR spectroscopic imaging for a liposomal drug delivery system. Reviewed International journal

    Ken-ichiro Matsumoto, Tomoaki Yahiro, Ken-ichi Yamada, Hideo Utsumi

    Magnetic resonance in medicine   53 ( 5 )   1158 - 65   2005.5

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  • A composition resonator assembly suitable for EPR/NMR co-registration imaging Reviewed

    Matsumoto S, Nagai M, Yamada K, Hyodo F, Yasukawa K, Muraoka M, Hirata H, Ono M, Utsumi H

    Concepts in Magnetic Resonance Part B Magnetic Resonance Engineering   25B ( 1 )   1 - 11   2005.1

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    A composition resonator assembly suitable for EPR/NMR co-registration imaging

  • [Redox dynamics in hyperthermia in rat livers by ESR spectroscopy].

    Y. Cao, Zhen Zhao, Kenichi Yamada, Hideo Utsumi

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology   20 ( 4 )   329 - 332   2004.11

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  • [Redox dynamics in hyperthermia in rat livers by ESR spectroscopy]. International journal

    Yu Cao, Zhen Zhao, Kenichi Yamada, Hideo Utsumi

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology   20 ( 4 )   329 - 32   2004.11

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  • In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries. Reviewed International journal

    Utsumi H, Ken-ichi Yamada

    416 ( 1 )   1 - 8   2003.8

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    Other Link: https://www.ncbi.nlm.nih.gov/pubmed/12859975

  • Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. Reviewed International journal

    Mito F, Kitagawa K, Yamasaki T, Shirahama C, Oishi T, Ito Y, Yamato M, Yamada K.

    Free Radic Res   1900

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  • Tempol intake improves inflammatory status in aged mice

    Mayumi Yamato, Ayumi Ishimatsu, Yuki Yamanaka, Takara Mine, Ken-ichi Yamada

    J Clin Biochem Nutr   1900

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  • Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects. Reviewed International journal

    Yamato M, Shiba T, Ide T, Honda Y, Yamada KI, Tsutsui H.

    Hypertens Res   1900

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  • In vivo imaging of mitochondrial function in methamphetamine-treated rats. Reviewed International journal

    Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada KI.

    Neuroimage   1900

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Books

  • Yamada's textbook of gastroenterology

    Wang Timothy C., Camilleri Michael, Lebwohl Benjamin, Lok Anna S., Sandborn William J., Wang Kenneth K., Wu Gary D., Yamada Tadataka

    Wiley Blackwell  2022    ISBN:9781119600169

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    Language:English  

    CiNii Books

  • Yamada's textbook of gastroenterology

    Wang Timothy C., Camilleri Michael, Lebwohl Benjamin, Lok Anna S., Sandborn William J., Wang Kenneth K., Wu Gary D., Yamada Tadataka

    Wiley Blackwell  2022    ISBN:9781119600169

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    Language:English  

    CiNii Books

  • Yamada's textbook of gastroenterology

    Wang Timothy C., Camilleri Michael, Lebwohl Benjamin, Lok Anna S., Sandborn William J., Wang Kenneth K., Wu Gary D., Yamada Tadataka

    Wiley Blackwell  2022    ISBN:9781119600169

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    Language:English  

    CiNii Books

  • Synthesis and Utilization of α-Substituted Nitroxides.

    ( Role: Joint author)

    2012.9 

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    Responsible for pages:247-262   Language:English   Book type:Scholarly book

  • In vivo ESR/Spin Probe Technique. Methods in Redox Signaling (Edited by Dipak Das),

    Yasukawa K, Yamada K, Ichikawa K, Utsumi H.( Role: Joint author)

    Westchester Book Services (Danbury, CT)  2009.5 

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    Language:English   Book type:Scholarly book

  • 動物個体でのESR計測

    山田健一、大和真由実、村上君代、内海英雄( Role: Joint author)

    日本学会事務センター  2003.1 

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    Responsible for pages:195-201頁「電子スピンサイエンス&スピンテクノロジー入門」(電子スピンサイエンス学会監修)   Language:Japanese   Book type:Scholarly book

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Presentations

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions. International conference

    Mirinthorn JUTANOM

    The 9th JAPAN-TAIWAN Joint Symposium  2024.9 

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    Event date: 2024.9

    Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • Elucidation of head-modified phospholipids functions International conference

    大田 友輝, Jutanom Mirinthorn, 廣保 郁, 上野 亮哉, 小櫻 英翔, 山田 健一

    The 9th JAPAN-TAIWAN Joint Symposium  2024.9 

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    Event date: 2024.9

    Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • 酸化脂質分析から切り開く創薬基盤研究

    山田 健一

    第36回バイオメディカル分析科学シンポジウム  2024.8 

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    Event date: 2024.8

    Presentation type:Oral presentation (invited, special)  

    Venue:誌面開催   Country:Japan  

  • 求電子性酸化脂質を捕捉する蛍光プローブの開発

    川野 蒼太, 田添 果歩, 松岡 悠太, 高橋 政友, 和泉 自泰, 馬場 健史, 森本 和志, Jutanom Mirinthorn, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム  2024.8 

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    Event date: 2024.8

    Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • 血管性認知症における脂質過酸化反応を起点とした慢性炎症

    萩森 諒, 阿部 真紗美, 上野 亮哉, Jutanom Mirinthorn, 森本 和志, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム  2024.8 

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    Event date: 2024.8

    Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • Exploring novel oxidized phospholipids to elucidate an exhaustive understanding of their functions International conference

    Mirinthorn JUTANOM

    第50回日本毒性学会学術集会  2024.7 

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    Event date: 2024.7

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:福岡   Country:Japan  

  • ox-LDLはヒト網膜色素上皮細胞のエネルギー代謝を変容させる

    友松愛美、今村直人、和泉星余、池田昌隆、井手友美、内之宮祥平、王子田彰夫、Jutanom Mirinthorn、森本和志、山田健一

    令和6年度日本生化学会九州支部例会  2024.6 

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    Event date: 2024.6

    Presentation type:Poster presentation  

    Venue:熊本   Country:Japan  

  • 血管性認知症モデルマウスに対する脂質過酸化反応抑制剤の病態保護効果

    萩森諒、阿部真紗美、Jutanom Mirinthorn、森本和志、山田健一

    令和6年度日本生化学会九州支部例会  2024.6 

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    Event date: 2024.6

    Presentation type:Poster presentation  

    Venue:熊本   Country:Japan  

  • LC/MS/MS解析による炎症反応を惹起する新規生理活性酸化リン脂質の同定

    上野亮哉、岩尾彬広、小櫻英翔、高橋政友、和泉自泰、馬場健史、加藤俊治、仲川清隆、松岡悠太、Jutanom Mirinthorn、森本和志、山田健一

    令和6年度日本生化学会九州支部例会  2024.6 

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    Event date: 2024.6

    Presentation type:Poster presentation  

    Venue:熊本   Country:Japan  

  • Detection and structural analysis for lipid radicals and oxidized phospholipids and validation in disease models Invited International conference

    Ken-ichi Yamada

    The 1st International G-ReXS Conference  2024.3 

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    Event date: 2024.3 - 2024.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • クリックケミストリーに応用可能な脂質ラジカル検出プローブの開発

    #川野 蒼太、@田中 萌、@齋藤 耕太、@松岡 悠太、@森本 和志、@Jutanom Mirinthorn、@山田 健一

    日本薬学会第144年会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • ox-LDLはヒト網膜色素上皮細胞の代謝変容を誘導する

    #友松 愛美、#今村 直人、@和泉 星余、@池田 昌隆、@井手 友美、@内之宮 祥平、@王子田 彰夫、@Jutanom Mirinthorn、@森本 和志、@山田 健一

    日本薬学会第144年会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • 血管性認知症モデルマウスにおける脂質過酸化反応阻害剤の炎症抑制効果

    #萩森 諒、#阿部 真紗美、@Jutanom Mirinthorn、@森本 和志、@山田 健一

    日本薬学会第144年会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • 極性頭部が修飾された酸化フォスファチジルエタノールアミン解析手法の開発

    #廣保 郁、#小櫻 英翔、@Mirinthorn Jutanom、@森本 和志、@山田 健一

    日本薬学会第144年会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • 脂質/レドックスシグナル研究の最前線:新たな相互作用から生命の生存戦略を解き明かす

    @山田健一

    第97回日本薬理学会年会  2023.12 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:兵庫   Country:Japan  

  • オキシリピドミクス解析を用いたミクログリアの炎症応答を制御する新規酸化リン脂質の同定

    #上野亮哉、@岩尾彬広、#小櫻英翔、@高橋政友、@和泉自泰、@馬場健史、@加藤俊治、@仲川清隆、@松岡悠太、@Mirinthorn Jutanom、@森本和志、@山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 機能性ニトロキシドプローブを用いた微量脂質ラジカル付加体精製法の開発と応用

    #田中萌、@齋藤耕太、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@Jutanom Mirinthorn、@森本和志、@山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 蛍光プローブを用いたチオール基反応性求電子性酸化脂質の探索

    #田添佳歩、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@森本和志、@Jutanom Mirinthorn、@山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • フェロトーシス耐性に対するAKR1Cの関与

    #吉田汐里、@森本和志、@松岡悠太、@Jutanom Mirinthorn、@山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ヒト網膜色素上皮細胞の代謝変容に対するox-LDLの作用

    #友松愛美、#今村直人、@和泉星余、@池田昌隆、@井手友美、@内之宮祥平、@王子田彰夫、@Mirinthorn Jutanom、@森本和志、@山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 網膜色素上皮細胞で生じる代謝変動におけるox-LDLの関与

    #友松愛美、#今村直人、@和泉星余、@池田昌隆、@井手友美、@森本和志、@山田健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 酸化脂質が関与する多様な細胞死研究の最前線

    @山田健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 酸化脂質の構造解析から硫黄との反応分子探索へ

    @山田健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 脂質過酸化反応が引き起こす生体応答

    @森本 和志, @松岡 悠太, @山田 健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • フェロトーシスを特徴づける酸化リン脂質の探索

    #陣内優佳、@中英人、#伊藤綾人、@Jutanom Mirinthorn、@森本和志、@松岡悠太、@山田健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    #上野亮哉、@岩尾彬広、#小櫻英翔、@高橋政友、@和泉自泰、@馬場健史、@加藤俊治、@仲川清隆、@松岡悠太、@Mirinthorn Jutanom、@森本和志、@山田健一

    第96回日本生化学会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 酸化脂質の検出及び疾患との関連 Invited

    @山田健一

    第13回機能油脂懇話会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • 網膜色素上皮細胞で生じる代謝変動に対するox-LDL の作用解明

    #友松愛美、#今村直人、@和泉星余、@池田昌隆、@井手友美、@内之宮祥平、@王子田彰夫、@Mirinthorn Jutanom、@森本和志、@山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ソソーム脂質過酸化反応はリソソーム膜を破壊しフェロトーシスを誘導する

    #斎元祐真、@森本和志、#日下部大樹、@松岡悠太、@平山佑、@唐澤悟、@山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    #上野亮哉、#岩尾彬広、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@加藤俊治、@仲川清隆、@Mirinthorn Jutanom、@森本和志、@山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Determination of the responsible gene for oxidized phosphatidylcholine translocation in apoptosis

    2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 求電子性酸化脂質を捕捉する蛍光プローブの開発

    #田添佳歩、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@森本和志、 @Jutanom Mirinthorn、@山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ニトロキシドプローブを用いた脂質ラジカル付加体精製法の開発と応用

    #田中萌、@齋藤耕太、@松岡悠太、@高橋政友、@森本和志、@和泉自泰、@馬場健史、@山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • リソソームの脂質過酸化反応がフェロトーシス誘導の引き金になる

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@平山祐、@山田健一

    薬学会・生物系薬学部会(PBF2023)  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • フェロトーシス誘導時に生成する酸化脂質の検出・構造解析技術

    @山田健一

    第47回日本鉄バイオサイエンス学会学術集会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡山   Country:Japan  

  • 脂質ラジカル・酸化リン脂質の検出・構造解析技術と疾患モデルにおける検証

    @山田健一

    第45会 光医学・光生物学会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:島根   Country:Japan  

  • フェロトーシスで誘導される脂質酸化メカニズムと細胞小器官局在性

    #斎元祐真, @森本和志 ,#日下部大樹 ,@松岡悠太 ,@平山佑 ,@唐澤悟 ,@山田健一

    第65回日本脂質生化学会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • フェロトーシスを特徴づける酸化リン脂質の探索

    #陣内優佳, #中英人, #伊藤綾人, @Jutanom Mirinthorn, @森本和志, @松岡悠太, @山田健一

    酸化脂質研究会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • リソソームに着目したフェロトーシス誘導メカニズムの解析

    #斎元祐真, @森本和志, 日下部大樹, @山田健一

    酸化脂質研究会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 網膜色素上皮細胞で生じる代謝リプログラミングにおける酸化LDLの関与

    #友松愛美, #今村直人,@和泉星余,@森本和志, @山田健一

    酸化脂質研究会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    #上野亮哉, #岩尾彬広, #小櫻英翔, @松岡悠太, @高橋政友, @和泉自泰, @馬場健史, @森本和志, @山田健一

    酸化脂質研究会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • リソソームでの脂質過酸化反応がフェロトーシス誘導を亢進する

    @津波古 光生、@斎元 祐真、#森本 和志、#松岡 悠太、#唐澤 悟、#山田 健一

    日本薬学会 第143年会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:北海道   Country:Japan  

  • 脂質過酸化反応抑制剤の探索と血管性認知症モデルマウスへの適用

    #阿部 真紗美、#宗 茉里恵、#進藤 早紀、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会 第143年会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:北海道   Country:Japan  

  • 炎症反応を惹起する酸化リン脂質の探索

    #上野 亮哉、#小櫻 英翔、#岩尾 彬広、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会 第143年会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:北海道   Country:Japan  

  • 酸化脂質の検出・構造解析と疾患モデル動物での解析

    @山田健一

    日本酸化ストレス学会フリーラジカルスクール2022  2023.2 

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    Event date: 2023.2

    Language:Japanese  

    Venue:北海道   Country:Japan  

  • チオール基反応性求電子性酸化脂質を捕捉する蛍光プローブの開発および応用

    #田添佳歩,@松岡悠太,@高橋政友,@和泉自泰,@馬場健史,@森本和志,@山田健一

    第61回電子スピンサイエンス学会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • ニトロキシドプローブを用いた脂質ラジカル付加体精製法の開発と応用

    #田中萌、#齋藤耕太、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@森本和志、@山田健一

    第61回電子スピンサイエンス学会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • 質量分析法を用いた酸化ホスファチジルコリンの包括的解析および可視化技術

    @松岡悠太, @高橋政友, @杉浦悠毅, @和泉自泰, @末松誠, @馬場健史, @山田健一

    第61回電子スピンサイエンス学会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • リソソーム脂質過酸化反応はリソソーム膜破壊を介してフェロト ー シスを誘導する

    #斎元祐真, @森本和志, #日下部大樹, @松岡悠太, @平山佑, @唐澤悟, @山田健一

    第61回電子スピンサイエンス学会  2022.12 

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    Event date: 2022.12

    Language:Japanese  

    Venue:熊本   Country:Japan  

  • 光誘発性網膜障害に対する脂質過酸化反応抑制剤 X の抑制効果

    #森 亮太 #城臺 更、@海津 幸子、@谷戸 正樹、@松岡 悠太、@森本 和志、@山田 健一

    第39回日本薬学会九州山口支部大会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 薬用植物抽出液ライブラリーを用いたフェロトーシス抑制剤の探索

    #城戸百香 、@松岡 悠太、@森本 和志 、@山田 健一

    第39回日本薬学会九州山口支部大会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 鉄過剰症における血漿中脂質関連因子の解析

    #松田和 、@松岡悠太、@森本和志、@山田健一

    第39回日本薬学会九州山口支部大会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 脂質過酸化反応抑制剤は光誘発性網膜障害を抑制する

    #森 亮太, #城臺 更, #石田 南人, #進藤 早紀, @海津 幸子, @谷戸 正樹, @松岡 悠太, @森本 和志, @山田 健一

    第95回日本生化学会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、@森本 和志 、#日下部大樹、@松岡 悠太、@唐澤悟、@山田 健一

    第95回日本生化学会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • Detection and structure analysis of lipid-derived radicals and oxidized phospholipids

    2022.10 

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    Event date: 2022.10 - 2022.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 酸化脂質の検出・構造解析と疾患モデル動物への応用

    @山田健一

    第43回 生体膜と薬物の相互作用シンポジウム  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:北海道   Country:Japan  

  • 脂質由来ラジカル・酸化リン脂質の検出・構造解析及び疾患モデルへの応用

    @山田健一

    第16回メタボロームシンポジウム  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:山形   Country:Japan  

  • 脂質ラジカル・酸化脂質の網羅的解析と疾患モデルへの応用

    @山田 健一

    第64回日本脂質生化学会  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 酸化ストレス疾患に関与する酸化脂質の検出・構造解析

    @山田 健一

    クロマトグラフィー次世代技術セミナー2022  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 脂質ラジカル・酸化リン脂質の検出・構造解析、そして疾患モデルへの応用

    @山田 健一

    日本ケミカルバイオロジー学会第16回年会  2022.5 

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    Event date: 2022.5 - 2022.6

    Language:Japanese  

    Venue:富山   Country:Japan  

  • 脂質過酸化反応抑制剤の血管性認知症モデルに対する病態保護効果

    #阿部 真紗美、#宗 茉里恵、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会第142年会  2022.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシスの分子メカニズムの最新研究

    @山田健一

    日本薬学会第142年会  2022.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 包括的酸化脂質解析手法の開発および非アルコール性脂肪肝炎モデルマウスへの応用

    #齋藤 耕太、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    日本薬学会第142年会  2022.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 酸化脂質をターゲットとした疾患メカニズム解明および創薬基盤研究

    @山田健一

    令和3年度領域会議「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」研究開発領域  2022.1 

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    Event date: 2022.1

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@山田健一

    第38回日本薬学会九州山口支部  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシス誘導時に生じる酸化リン脂質の包括的解析

    #中英人、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@山田健一

    第38回日本薬学会九州山口支部  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 光誘発性網膜障害における脂質過酸化反応抑制剤の網膜保護効果

    #城臺更、#森亮太、@海津幸子、@谷戸正樹、@松岡悠太、@山田健一

    第38回日本薬学会九州山口支部  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@山田健一

    レドックスR&D 戦略委員会 第1回若手シンポジウム  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシスを含む脂質酸化を起点とする多様な細胞死研究の最前線

    @山田健一

    第94回日本生化学会大会  2021.11 

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    Event date: 2021.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームで生じる脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@松岡悠太、@山田健一

    第42回生体膜と薬物の相互作用シンポジウム  2021.10 

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    Event date: 2021.10

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシス誘発に関わる酸化脂質はどのような分子が、どこで生成しているのか?

    @山田健一

    日本CellDeath学会 第29回学術集会  2021.7 

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    Event date: 2021.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームで生じる脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@松岡悠太、@山田健一

    第63回日本脂質生化学会  2021.6 

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    Event date: 2021.6

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 光誘発性網膜障害における脂質過酸化反応の検出と抑制

    #城臺更、#進藤早紀、@海津幸子、@谷戸正樹、@松岡悠太、@山田健一

    第15回日本分子イメージング学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームで生じる脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@松岡悠太、@山田健一

    第15回日本分子イメージング学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシス誘導時に生じる酸化リン脂質の包括的解析

    #中 英人 、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 建史、@山田 健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 酸化ホスファチジルコリンの包括的解析および可視化技術の開発

    @松岡 悠太、@山田 健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 長期間コエンザイムQ10低下細胞モデルのミドコンドリア呼吸鎖複合体の解析

    #齋藤 耕太、@松岡 悠太、@中尾 周平、@大金 賢司、@闐闐 孝介、@袖岡 幹子、@山田 健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 脂質過酸化反応抑制剤による血管性認知症モデルマウスの病態保護効果

    #阿部真紗美、#宗茉里恵、@松岡悠太、@山田健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 光誘発性網膜障害における脂質過酸化反応抑制剤の網膜保護効果

    城臺 更, 森 亮太, 中 英人, 石田 南人, 進藤 早紀, 海津 幸子, 谷戸 正樹, 松岡 悠太, 山田 健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@松岡悠太、@山田健一

    第74回日本酸化ストレス学会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 輸血後鉄過剰症における脂質酸化物の解析および新規バイオマーカーの探索

    #松田 和、@松岡 悠太、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 酸化ホスファチジルコリンの包括的解析および可視化技術の開発

    @松岡 悠太、@高橋 政友、@杉浦 悠毅、@和泉 自泰、@西山 和宏、@西田 基宏、@末松 誠、@馬場 健史、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 蛍光ニトロキシドプローブを用いた培養細胞内脂質ラジカルの検出および構造解析

    #有働 拓海、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • ニトロキシドプローブを用いた脂質ラジカルの捕捉および付加体精製法の開発

    #齋藤 耕太、@松岡 悠太、@中尾 周平、@大金 賢司、@闐闐 孝介、@袖岡 幹子、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 脂質過酸化反応抑制剤による血管性認知症モデルマウスの病態改善効果

    #阿部 真紗美、#宗 茉里恵、@松岡 悠太、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • リソソームで生じる脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元 祐真、#日下部 大樹、@松岡 悠太、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 光誘発性網膜障害における脂質過酸化反応抑制剤の網膜保護効果

    #城臺 更、#森 亮太、#中 英人、#石田 南人、#進藤 早紀、@海津 幸子、@谷戸 正樹、@松岡 悠太、@山田 健一

    日本薬学会第141年会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • フェロトーシス進行に関わる脂質ラジカルの蛍光イメージング

    #斎元 祐真、#日下部大樹、@松岡悠太、@山田健一

    第73回日本酸化ストレス学会  2020.10 

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    Event date: 2020.10

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 酸化脂質解析技術開発から創薬シーズ展開へ Invited

    @山田健一

    第73回日本酸化ストレス学会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • 病態における酸化ストレス研究の最前線

    @山田健一

    第20回日本抗加齢医学会総会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 新たな酸化脂質研究の潮流

    @山田健一

    第93回日本生化学会大会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン(ストリーミング配信)   Country:Japan  

  • 酸化脂質と疾患について ~検出から創薬展開まで~

    @山田健一

    第 2 回レドックス・酸化ストレス・フィトケミカルズ生体計測研究会  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:WEB   Country:Japan  

  • 非酵素的脂質過酸化反応により生成する酸化リン脂質の分取および生理活性評価

    #岩尾彬広、@松岡悠太、@山田健一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 脂質ラジカルの検出・構造解析および抑制

    @山田 建一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • フェロトーシス誘導細胞における脂質過酸化反応の蛍光イメージング

    #斎元 祐真, #日下部 大樹, @松岡 悠太, @山田 健一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 光誘発性網膜障害における脂質過酸化反応抑制剤の網膜保護効果

    #城臺更、#石田南人、#進藤早紀、#日下部大樹、@松岡悠太、@山田健一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 脂質過酸化反応抑制剤の慢性低灌流モデルマウスへの応用

    #阿部真紗美、#宗茉里恵、@松岡悠太、@山田健一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 脂質膜内にて進行する脂質過酸化反応の機序解明

    #中英人、@松岡悠太、@山田健一

    日本薬学会第140年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • Lipid Radicals Cause Light Induced-Retinal Degeneration International conference

    @Ken-ichi Yamada

    SFRRA+J 2019  2019.12 

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    Event date: 2019.12

    Language:English  

    Country:Australia  

  • Detection and inhibition of in vivo lipid-derived radicals International conference

    @Ken-ichi Yamada

    SfRBM2019  2019.11 

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    Event date: 2019.11

    Language:English  

    Country:United States  

  • 蛍光ニトロキシドプローブを用いた脂質ラジカル定量法の開発

    #有働 拓海, @松岡 悠太, @高橋 政友, @和泉 自泰, @馬場 健史, @山田 健一

    第36回日本薬学会九州支部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 酸化LDL中酸化脂質の包括的解析

    #阿部雅史, @松岡 悠太, @高橋 政友, @和泉 自泰, @馬場 健史, @山田 健一

    第36回日本薬学会九州支部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 脂質過酸化反応抑制剤は光誘発性網膜障害を抑制する

    #石田南人, #城臺更, #進籐早紀, @松岡悠太, @山田健一

    第36回日本薬学会九州支部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 脂質ラジカル-ニトロキシドプローブ付加体精製法の開発

    #齋藤 耕太, @松岡 悠太, @中尾 周平, @闐闐 孝介, @袖岡 幹子, @山田 健一

    第36回日本薬学会九州支部会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 糖尿病モデルマウスを用いた網膜症進展機序の解析

    @大和真由実、@加藤奈緒、@山田健一、@井口登輿志

    第57回日本糖尿病学会 九州地方会  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 脂質ラジカルの可視化と構造解析技術開発

    @山田 健一

    第41回生体膜と薬物の相互作用シンポジウム  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • リン脂質脂肪酸組成の調節はフェロトーシス誘導剤の感受性を制御する

    #日下部 大樹, @松岡 悠太, @山田 健一

    第92回日本生化学会  2019.9 

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    Event date: 2019.9

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Functional fluorescence probe for Lipid-derived radicals detection International conference

    Japan-Aston symposium on lipid oxidation in inflammation  2019.8 

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    Event date: 2019.8

    Language:Japanese  

    Country:United Kingdom  

  • オキシリピドミクス技術開発を目指して Invited

    @山田 健一

    日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:宮崎   Country:Japan  

  • リゾリン脂質アシル転移酵素はフェロトーシス誘導感受性に関与する

    #日下部 大樹, @松岡 悠太, @山田 健一

    第61回日本脂質生化学会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 酸化LDL 中脂質由来アルデヒドの体系的解析

    #阿部 雅史, @松岡 悠太, @高橋 政友, @和泉 自泰, @馬場 健史, @山田 健一

    第61回日本脂質生化学会  2019.7 

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    Event date: 2019.7

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 腎症モデルマウスにおける脳障害の機序解明

    #廣石 将和、 @大和 真由実、@松岡 悠太、@山田 健一

    第72回日本酸化ストレス学会  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • Inhibitory Effects of Several Antioxidants toward Lipid Peroxidation International conference

    #Kota Saito,@Yuta Matsuoka,@Ken-ichi Yamada

    ICBL2019  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • A Method for the Structural Determination of Lipid-derived Radicals International conference

    ICBL2019  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • Sample preparation procedure for oxidized phospholipids International conference

    ICBL2019  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • 脂質由来アルデヒド化合物の構造同定と包括的解析法開発

    @松岡 悠太,#阿部雅史,@和泉 自泰,@ 高橋 政友,@馬場 健史,@山田 健一

    第7回ケミカルバイオロジー学会  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 脂質由来ラジカル種の構造解析法

    @松岡 悠太,@和泉 自泰,@ 高橋 政友,@馬場 健史,@山田 健一

    第67回質量分析総合討論会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  • Inhibitory effects of several anti-oxidants toward lipid peroxidation International conference

    SFRR-Asia 2019  2019.4 

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    Event date: 2019.4

    Language:Japanese  

    Country:Japan  

  • 脂質ラジカルの可視化と構造解析 Invited

    @山田 健一

    第6回JFAS (脂肪酸をテーマとした研究会)  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 安定同位体標識ニトロキシドプローブを用いた脂質ラジカルの網羅的定量分析法の開発

    #有働 拓実、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    日本薬学会 第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:千葉   Country:Japan  

  • 脂肪酸添加はがん細胞のフェロトーシス感受性を亢進させる

    #日下部 大樹、@松岡 悠太、@山田 健一

    日本薬学会 第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 脂質ラジカル抑制剤探索に向けたスクリーニング系の構築とその応用

    #進籐 早紀、@松岡 悠太、@山田 健一

    日本薬学会 第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 脂質過酸化反応における抗酸化物質の作用点および反応抑制機序の解明

    #齋藤 耕太、@松岡 悠太、@山田 健一

    日本薬学会 第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 酸化脂質由来アルデヒド化合物の体系的解析法開発

    #阿部 雅史、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    日本薬学会 第139年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 極性基を導入した水溶性NOラジカルの合成と水プロトン緩和能評価

    #白石 諒馬、@松岡悠太、@渕 靖史、@長沼辰弥、@山田健一、@唐澤 悟

    日本化学会 第99春季年会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 脂質ラジカル選択的蛍光・質量分析マルチプローブの開発と疾患モデルへの適用

    @ 山田健一

    AMED-CREST/JSTさきがけ 疾患代謝 合同領域会議  2019.2 

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    Event date: 2019.2

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 酸化脂質をターゲットとした疾患メカニズム解明および創薬基盤研究

    @ 山田健一

    革新的先端研究開発支援事業 研究開発領域「画期的医薬品の創出をめざす脂質の生理活性と機能の解明」 H30年度領域会議  2019.1 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 酸化脂質の検出と疾患 Invited

    @ 山田健一

    第177回東京脂質談話会  2019.1 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 脂質ラジカルの可視化と構造解析技術開発 Invited

    @ 山田健一

    第30回ビタミンE研究会  2019.1 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • SGLT2 阻害薬の慢性腎臓病(CKD)モデルアデニン腎症に対する改善効果

    @大和真由実, @垣野愛, @加藤奈緒, @ 山田健一, @井口登與志

    第30 回日本糖尿病性腎症研究会  2018.12 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 脂質過酸化反応における抗酸化物質の作用点および反応機構解明

    #齋藤耕太、@松岡 悠太、@山田 健一

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 生体内組織サンプルより生成する脂質ラジカルの検出と構造解析

    #生津 慎、@松岡悠太、@和泉自泰、@高橋政友、@馬場健史、@山田健一

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 非アルコール性脂肪肝炎モデルへの脂質過酸化抑制剤の応用

    #北島綾子、#日下部 大樹、#進藤 早紀、@松岡 悠太、@山田 健一

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 脂質過酸化反応を抑制する化合物の探索と両側総頸動脈狭窄モデルマウスへの応用

    #宗 茉里恵、#進藤 早紀、@松岡 悠太、@山田 健一

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 酸化脂質由来アルデヒド化合物の構造解析手法の開発とその応用

    #阿部 雅史、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    第35回日本薬学会九州支部大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 脂質過酸化反応における抗酸化物質の作用点および反応機構解明

    #齋藤耕太、@松岡悠太、@山田健一

    第57電子スピンサイエンス学会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:北海道大学   Country:Japan  

  • 酸化脂質の起点として脂質ラジカルの検出と構造解析技術開発

    @山田 健一

    第91回日本生化学会大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都国際会議場   Country:Japan  

  • 様々な置換基を有する 5 員環 NO ラジカルの合成と水プロトン緩和能評価

    #白石諒馬 、@松岡悠太、@渕靖史、@金子知世、@青木伊知男、@山田健一、@唐澤 悟

    第48回複素環化学討論会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎ブリックホール国際会議場(長崎市)   Country:Japan  

  • LC/HRMS/MSを用いた酸化脂質由来アルデヒド体の構造解析手法の開発

    #阿部 雅史、@松岡 悠太、@高橋 政友、@和泉 自泰、@馬場 健史、@山田 健一

    第31回バイオメディカル分析シンポジウム  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学(福岡市)   Country:Japan  

  • 脂質ラジカル検出手法の開発と疾患モデルへの応用 Invited

    @山田健一

    第31回バイオメディカル分析シンポジウム  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学(福岡市)   Country:Japan  

  • クリックケミストリーを応用したLDL中脂質ラジカルの検出および構造解析法の開発

    #塚田大昂、@松岡悠太、@山田健一

    第1回AMED-CREST酸化脂質山田班研究会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北里大学(東京都港区)   Country:Japan  

  • 脂質由来ラジカル種の構造解析法

    @松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@山田健一

    第1回AMED-CREST酸化脂質山田班研究会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 脂質由来アルデヒド化合物の構造解析とその応用

    #阿部雅史、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@山田健一

    第1回AMED-CREST酸化脂質山田班研究会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 四塩化炭素誘発肝障害モデルマウスにおける脂質過酸化の関与の解明

    #多田有佐、#北島綾子、@山田健一

    第1回AMED-CREST酸化脂質山田班研究会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北里大学(東京都港区)   Country:Japan  

  • アミノ酸・タンパク質由来ラジカル種検出法の開発

    #岡本祐佳、#石田悠馬、@松岡悠太、@山田健一

    第1回AMED-CREST酸化脂質山田班研究会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北里大学(東京都港区)   Country:Japan  

  • ニトロキシドラジカル誘導体による脂質由来ラジカル種の解析

    @松岡悠太@山田健一

    第22回ESRフォーラム研究会  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 2 極性基を導入した水溶性 NO ラジカルの合成と緩和能評価

    #白石諒馬、@松岡悠太、@渕靖史、@金子知世、@青木伊知男、@山田健一、@唐澤悟

    第29回基礎有機化学討論会  2018.9 

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    Event date: 2018.6 - 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学大岡山キャンパス   Country:Japan  

  • Functional fluorescence probe for lipid derived radicals detection International conference

    19th Biennial Meeting SFRRI2018  2018.6 

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    Event date: 2018.6

    Language:English  

    Country:Portugal  

  • 脂質ラジカルの検出と構造解析技術開発

    @山田健一

    第71回日本酸化ストレス学会,第18回日本NO学会 合同学術集会  2018.5 

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    Event date: 2018.5

    Language:Japanese  

    Venue:京都   Country:Japan  

  • Detection and Inhibition of Lipid-derived Radical Invited International conference

    2018.4 

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    Event date: 2018.4 - 2018.3

    Language:English  

    Country:Thailand  

  • 腎不全モデルマウスにおける脳障害発症の機序解明

    #廣石将和、@大和真由美、@山田健一

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:金沢(石川県)   Country:Japan  

  • 第三世代EGFR-TKIオシメルチニブ耐性肺癌細胞は代替経路としてSFK/Akt経路を活性化する

    #日下部大樹、@村上雄一、@渡公佑、@山田健一、@小野眞弓

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢(石川県)   Country:Japan  

  • 脂質断片化産物の一斉分析法の開発とデータベース構築

    #阿部雅史、@松岡悠太、@山田健一

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:金沢(石川県)   Country:Japan  

  • 漢方薬の加齢黄斑変性症モデル動物への応用

    #石田南人、#進藤早紀、@山田健一

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:金沢(石川県)   Country:Japan  

  • 脂肪酸酸化酵素を用いた脂質過酸化反応機序の解明

    #齋藤耕太、@松岡悠太、@山田健一

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:金沢(石川県)   Country:Japan  

  • 極性基を有する水溶性NOラジカルを用いたメタルフリーMRI造影剤の構築

    #白石諒馬、#村山周平、@松岡悠太、@金子知世、@青木伊知男、@山田健一、@唐澤悟

    日本化学会第98春季年会(2018)  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:千葉(船橋)   Country:Japan  

  • 脂質ラジカル構造解析技術開発

    @山田 健一

    第15回レドックス・ライフイノベーションシンポジウム  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学(東京)   Country:Japan  

  • 脂質ラジカル選択的蛍光・量分析マチプローブの開発と 疾患モデルへの適用

    @山田 健一

    第5回さきがけ領域会議  2018.2 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • Fluorescence probes to detect lipid-derived radicals International conference

    8th Joint meeting of society for free radical research Australasia and Japan with International symposium on coenayme Q10  2017.12 

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    Event date: 2017.12

    Language:English  

    Country:Japan  

  • Lipid Radicals Cause Light Induced-Retinal Degeneration International conference

    24th Annual SfRBM meeting  2017.11 

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    Event date: 2017.11 - 2017.12

    Language:English  

    Country:United States  

  • Detection and Inhibition for Lipid Derived Radicals International conference

    A Workshop on Drawing Biological Information through Quantum Spin System  2017.11 

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    Event date: 2017.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 四塩化炭素誘発肝障害における脂質過酸化反応の役割

    #多田有佐,@松岡悠太,@山田健一

    第34回日本薬学会九州支部大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:崇城大学(熊本)   Country:Japan  

  • Click Chemistryを応用した脂質ラジカル標識化剤の開発

    #三倉唯,@松岡悠太,@山田健一

    第34回日本薬学会九州支部大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:崇城大学(熊本)   Country:Japan  

  • 脂質酸化中間体の検出と創薬ターゲットとしての可能性 Invited

    山田 健一

    昭和薬科大学招待講演  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 脂質酸化中間体の検出と創薬ターゲットとしての可能性 Invited

    山田 健一

    日本薬学部九州大学支部会特別講演会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • 酸化脂質の検出から創薬展開を目指して Invited

    山田 健一

    第33回九大薬友会関西支部同窓会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • Fluorescence probes to detect lipid-derived radicals Invited International conference

    8th Pacific Symposium on Radical Chemistry (PSRC-8)  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  • 脂質ラジカル検出手法の開発と疾患モデルへの応用 Invited

    山田 健一

    第70回日本酸化ストレス学会学術集会  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  • Detection and inhibition for lipid-derived radicals Invited International conference

    Mahidol University  2017.6 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • 脂質ラジカル蛍光検出プローブを用いた疾患モデルへの応用

    山田 健一

    第59回日本脂質生化学学会  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 脂質由来ラジカルの選択的蛍光標識化法と構造解析・定量分析への応用

    松岡 悠太, 高橋 政友, 和泉 自泰, 馬場 健史, 山田 健一

    日本ケミカルバイオロジー学会第12回年会  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • 酸化還元反応をターゲットとした造影剤開発

    山田 健一

    量子イメージング創薬アライアンス「次世代MRI・造影剤」キックオフ国際シンポジウム  2017.5 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:お台場   Country:Japan  

  • 脂質過酸化反応による肝障害制御機構の解明

    多田 有佐, 松岡 悠太, 山田 健一

    日本薬学会 第137年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:仙台   Country:Japan  

  • レドックス応用型プローブ・HPLC蛍光検出系を用いた細胞内レドックスバランスの評価手法の開発

    三倉 唯, 松岡 悠太, 山田 健一

    日本薬学会 第137年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:仙台   Country:Japan  

  • 脂質ラジカルの検出と疾患への応用 Invited

    山田 健一

    第13回レドックス・ライフイノベーションシンポジウム  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  • Fluorescence probes to detect lipid-derived radicals and its application Invited International conference

    JSPS-NRCT 2017 and IAMPS33  2017.3 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • 脂質ラジカルの検出と構造解析技術開発

    山田 健一

    第7回学際的脂質創生研究部会講演会  2017.1 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九大西新プラザ   Country:Japan  

  • Fluorescence probes to detect lipid-derived radicals Invited International conference

    Frontiers2016 joint Symposium of the EPFL  2016.12 

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Switzerland  

  • 加齢黄斑変性の発症における脂質ラジカルの影響

    榎木 将貴, 海津 幸子, 大平 明弘, 谷戸正樹, 山田 健一

    薬学会(九州支部会)  2016.12 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • 脂質由来フラグメントラジカルを標的とした脂質ラジカル構造推定手法の開発

    生津 慎, 松岡 悠太, 和泉 自泰, 高橋 政友, 馬場 健史, 山田 健一

    薬学会(九州支部会)  2016.12 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • Fluorescence Probes to Detect Lipid-derived Radicals and Its Application International conference

    2016 ISLS  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Taiwan, Province of China  

  • Fluorescence Probes to Detect Lipid-Derived Radicals International conference

    SFRBM's 23rd Annual Meeting  2016.11 

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    Event date: 2016.11

    Language:English  

    Country:United States  

  • Functional fluorescence probe for lipid derived radicals detection International conference

    2016 World Molecular Imaging Congress  2016.9 

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    Event date: 2016.9

    Language:English  

    Country:United States  

  • アスコルビン酸の迅速かつ高感度な検出に向けた長波長蛍光ニトロキシド化合物の開発

    松岡 悠太, 大久保 敬, 福住 俊一, 山田 健一

    第29回バイオメディカル分析科学シンポジウム  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • HPLC-蛍光・質量分析システムによる脂質由来ラジカルの構造分析

    生津 慎, 松岡 悠太, 和泉 自泰, 高橋 政友, 馬場 健史, 山田 健一

    第29回バイオメディカル分析科学シンポジウム  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 肥満症における生体内レドックス不均衡の是正

    山田 健一, 雑賀 美紗子, 進藤 早紀, 山中 佑記, 河野 君佳, 大和 真由実

    第69回日本酸化ストレス学術集会  2016.8 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • 脂質由来ラジカル種の蛍光検出・構造推定手法

    松岡 悠太, 山田 健一

    第11回日本ケミカルバイオロジー学会  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Involvement of NO with the activation of CD14-TLR4-NF-kB axis in mice with DSS-induced colitis

    Tun Xin, Keiji Yasukawa, Ken-ichi Yamada

    2016.5 

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    Event date: 2016.5

    Language:English  

    Country:Japan  

  • Synthesis and evaluation of 2,6-substituted TEMPO derivatives

    Toshihide Yamasaki, Yuta Matsuoka, Ken-ichi Yamada

    2016.5 

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    Event date: 2016.5

    Language:English  

    Country:Japan  

  • 脂質由来ラジカル種の蛍光検出・構造推定法の開発

    松岡 悠太, 山田 健一

    日本薬学会 第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 脂質ラジカル蛍光検出プローブの体内動態評価

    多田 有佐, 松岡 悠太, トンシン, 山田 健一

    日本薬学会 第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • ニトロキシド化合物による酸化ストレス誘発性細胞

    進藤 早紀, 松岡 悠太, 山田 健一

    日本薬学会 第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 酸化 LDL 中の脂質由来ラジカルを標的とした TurnON型蛍光プローブの開発

    石田 悠馬, 松岡 悠太, 山田 健一

    日本薬学会 第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • DSS惹起大腸炎マウスのCD14-TLR4-NF-κBシグナル経路に対するNOの作用

    トンシン, 安川 圭司, 山田 健一

    日本薬学会 第136年会  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • Functional fluorescence probe for lipid derived radicals detection

    Pacifichem 2015  2015.12 

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Long wavelength fluorescent probe for a highly sensitive quick detection of ascorbic acid

    Pacifichem 2015  2015.12 

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    Event date: 2015.12

    Language:English  

    Country:United States  

  • 蛍光ニトロキシドプローブを用いたミトコンドリア内還元ストレスの検出・評価

    日下部 大樹, 松岡 悠太, 山田 健一

    第32回日本薬学会九州支部大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • ニトロキシド化合物の酸化ストレス刺激時における細胞死抑制効果と作用機序の解明

    進藤 早紀, 松岡 悠太, 山田 健一

    第32回日本薬学会九州支部大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • Synthesis and Evaluation of Redox Active Compound to Improve Both Oxidative and Reductive Stress in Metabolic Syndrome

    7th Biennial Meeting of Society for Free Radical Research-Asia  2015.11 

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    Event date: 2015.11 - 2015.12

    Language:English  

    Country:Thailand  

  • ミトコンドリア内還元ストレスの検出に向けた蛍光プローブの開発

    日下部 大樹, 松岡 悠太, 山田 健一

    第28回 バイオメディカル分析科学シンポジウム  2015.8 

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    Event date: 2015.8

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • 生体内酸化・還元ストレス双方の是正を目指した有機セレン化合物の開発

    石田 悠馬, 松岡 悠太, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム  2015.8 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • ミトコンドリア内還元ストレスの検出に向けた蛍光プローブの開発・評価

    日下部 大樹, 松岡 悠太, 山田 健一

    次世代を担う若手のためのフィジカル・ファーマフォーラム  2015.8 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • アスコルビン酸の迅速かつ高選択的な検出に向けた長波長蛍光プローブの開発

    松岡 悠太, 大久保 敬, 井出 皐月, 式町 和茂, 福住 俊一, 山田 健一

    第68回 日本酸化ストレス学会学術集会  2015.6 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 不飽和脂肪酸由来ラジカル種の検出・構造解析手法の開発

    松岡 悠太, 大久保 敬, 井出 皐月, 式町 和茂, 福住 俊一, 山田 健一

    第57回日本脂質生化学会  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ESRを用いた生体内反応の測定 スピンラベル法 と スピントラップ法

    山田 健一

    第11回ESR入門セミナー  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 脂質由来ラジカル種の選択的検出を可能とする還元反応性抵抗性蛍光プローブの開発

    松岡 悠太, 大久保 敬, 井出 皐月, 式町 和茂, 福住 俊一, 山田 健一

    日本薬学会 第135年会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • ミトコンドリア内酸化ストレスを検出可能な蛍光プローブの開発

    日下部 大樹, 山﨑 俊栄, 松岡 悠太, 山田 健一

    日本薬学会 第135年会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 脂質ラジカルをターゲットとした機能性造影剤の開発

    山田 健一

    日本薬学会第135年会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • Development and Application of α-Substituented Piperidine Nitroxides Invited International conference

    2014.8 

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    Event date: 2014.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Pusan National University   Country:Korea, Republic of  

  • 多様な酸化還元電位を有するニトロキシドの開発とその応用 Invited

    山田 健一

    第18回ESRフォーラム研究会  2014.7 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 脂質ラジカル蛍光プローブの設計と疾患モデルへの応用 Invited

    山田 健一

    日本生物物理学会九州支部・熊本大学イメージングセミナー  2014.4 

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    Event date: 2014.4

    Language:Japanese  

    Venue:熊本大学   Country:Japan  

  • DSS惹起大腸炎マウスにおけるNOのCD14-TLR4-NF-κBシグナル増強

    トンシン, 安川 圭司, 山田 健一

    第68回 日本酸化ストレス学会学術集会  2015.6 

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    Venue:鹿児島   Country:Japan  

  • Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch International conference

    Ken-ichi Yamada, Yuta Matsuoka, Mayumi Yamato, Toshihide Yamasaki, Fumiya Mito

    SFRRI2014 

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    Country:Japan  

  • Debelopment and utilization of profluorescent nitroxide International conference

    Ken-ichi Yamada, Toshihide Yamasaki

    SPIN2014 

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    Language:English   Presentation type:Oral presentation (general)  

    Country:Russian Federation  

  • High selective and high sensitive detection method for ascorbic acid using a profluorescent nitroxide International conference

    Ken-ichi Yamada, Yuta Matsuoka, Mayumi Yamato, Toshihide Yamasaki, Fumiya Mito

    SFRBM's 21st Annual Meeting 

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    Language:English  

    Country:United States  

  • 脂質ラジカル検出のための蛍光プローブの開発と応用

    山田 健一

    神戸薬科大学研究セミナー  2014.5 

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    Country:Japan  

  • Development and Application of α-Substituented Piperidine Nitroxides Invited International conference

    2015.2 

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    Venue:Mahidol University   Country:Thailand  

  • 脂質ラジカル蛍光プローブの設計と疾患モデルへの応用

    山田 健一

    第15回創薬リサーチコア研究会/第14回薬学研究院若手セミナー  2015.3 

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    Venue:福岡   Country:Japan  

  • Tempolによる細胞内NAD+/NADH比制御と下流因子の解析

    進藤 早紀, 雑賀 美紗子, 河野 君佳, 山中 佑記, 大和 真由実, 山田 健一

    第68回 日本酸化ストレス学会学術集会  2015.6 

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    Venue:鹿児島   Country:Japan  

  • 生体内レドックス不均衡の是正を目指した新規酸化還元物質の開発

    石田 悠馬, 松岡 悠太, 山田 健一

    第68回 日本酸化ストレス学会学術集会  2015.6 

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    Venue:鹿児島   Country:Japan  

  • 革新的解析法で挑む生体内脂質酸化反応とレドックス制御研究の最先端 酸化脂質の構造解析から硫黄との反応分子探索へ

    山田 健一

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • 酸化脂質研究の最前線 脂質ラジカル・酸化脂質の網羅的解析と疾患モデルへの応用

    山田 健一

    脂質生化学研究  2022.5  日本脂質生化学会

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  • 脂質過酸化反応抑制剤は光誘発性網膜障害を抑制する

    森 亮太, 城臺 更, 石田 南人, 進藤 早紀, 海津 幸子, 谷戸 正樹, 松岡 悠太, 森本 和志, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2022.11  (公社)日本生化学会

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  • 脂質過酸化反応抑制剤の血管性認知症モデルに対する病態保護効果

    阿部 真紗美, 宗 茉里恵, 松岡 悠太, 森本 和志, 山田 健一

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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  • 網膜色素上皮細胞で生じる代謝変動におけるox-LDLの関与

    友松 愛美, 今村 直人, 和泉 星余, 池田 昌隆, 井手 友美, 森本 和志, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • 糖尿病網膜症の初期メカニズムとSGLT2の役割

    大和 真由実, 加藤 奈緒, 山田 健一, 井口 登與志

    日本体質医学会雑誌  2022.6  日本体質医学会

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  • 糖尿病網膜症の初期メカニズムとSGLT2の役割

    大和 真由実, 加藤 奈緒, 山田 健一, 井口 登與志

    糖尿病  2023.5  (一社)日本糖尿病学会

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  • 炎症反応を制御する酸化リン脂質の探索

    上野 亮哉, 岩尾 彬広, 小櫻 英翔, 高橋 政友, 和泉 自泰, 馬場 健史, 松岡 悠太, 森本 和志, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • 包括的酸化脂質解析手法の開発および非アルコール性脂肪肝炎モデルマウスへの応用

    齋藤 耕太, 松岡 悠太, 高橋 政友, 和泉 自泰, 馬場 健史, 山田 健一

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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  • レドックスシグネチャーの生物学 脂質過酸化反応が引き起こす生体応答

    森本 和志, 松岡 悠太, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    斎元 祐真, 森本 和志, 日下部 大樹, 松岡 悠太, 唐澤 悟, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2022.11  (公社)日本生化学会

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  • フェロトーシス分子メカニズムの最新研究 心疾患におけるフェロトーシスの役割と病態における機序

    井手 友美, 池田 昌隆, 田所 知命, 宮本 裕子, 阿部 巧, 筒井 裕之, 山田 健一, 今井 浩孝

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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  • フェロトーシス分子メカニズムの最新研究 フェロトーシス誘発に関わる酸化脂質はどこで生成しているのか?

    山田 健一

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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  • フェロトーシスを特徴づける酸化リン脂質の探索

    陣内 優佳, 中 英人, 伊藤 綾人, Mirinthorn Jutanom, 森本 和志, 山田 健一

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • キラルNHCとカルボキシラートを触媒とするα-ヒドロキシアミドの速度論的光学分割のβ遮断薬合成への応用

    藤原 達也, 山内 映穂, 橋本 圭司, 猪熊 翼, 山田 健一

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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  • Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch International conference

    Ken-ichi Yamada, Yuta Matsuoka, Mayumi Yamato, Toshihide Yamasaki, Fumiya Mito

    SFRRI2014 

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    Venue:Kyoto   Country:Japan  

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  • High selective and high sensitive detection method for ascorbic acid using a profluorescent nitroxide International conference

    Ken-ichi Yamada, Yuta Matsuoka, Mayumi Yamato, Toshihide Yamasaki, Fumiya Mito

    SFRBM's 21st Annual Meeting 

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    Venue:Seattle, Washington   Country:United States  

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  • Debelopment and utilization of profluorescent nitroxide International conference

    Ken-ichi Yamada, Toshihide Yamasaki

    SPIN2014 

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    Venue:Zelenogradsk   Country:Russian Federation  

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  • 18F-FDG PET/MRIによるマウス網膜変性疾患モデルの評価

    松元 慎吾, 須藤 志保, 安井 博宣, 水野 雄貴, 久下 裕司, 山田 健一, 平田 拓

    JSMI Report  2023.5  日本分子イメージング学会

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MISC

  • 【フェロトーシス(鉄依存性細胞死)-そのメカニズムの解明と,治療への応用】酸化脂質とフェロトーシス惹起

    斎元 祐真, 山田 健一

    医学のあゆみ   290 ( 2 )   132 - 135   2024.7   ISSN:0039-2359

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    Language:Japanese   Publisher:医歯薬出版(株)  

    <文献概要>脂質過酸化反応に起因する細胞死機序であるフェロトーシスは,がんや神経変性疾患の新たな治療標的として注目されており,近年,急速に研究が進展している.なかでも,脂質過酸化反応の惹起や抑制メカニズムについては活発に研究が行われ,現在までに遊離二価鉄量の調節,膜リン脂質の不飽和度の制御,還元酵素による脂質過酸化反応の抑制がフェロトーシス制御に関わることが明らかにされてきた.さらに,フェロトーシスの最終過程において形質膜で細孔が形成され,浸透圧の膨張を引き起こすこともわかってきている.しかし,細胞内のどの部位で脂質過酸化反応が惹起され細胞死へと至るのか,またフェロトーシスの実行分子が何かについてはいまだ解明されていない.本稿ではフェロトーシス惹起メカニズムとして,まず脂質過酸化反応の誘導メカニズムをまとめ,細胞死実行因子としての酸化脂質研究の現状と課題点について概説したい.

  • 酸化脂質研究の最前線~検出・構造解析から疾患制御へ

    山田健一

    2024.2

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  • 【創薬を支える計測・検出技術の最前線】酸化脂質研究の最前線 検出・構造解析から疾患制御へ

    山田 健一

    Medchem News   34 ( 1 )   30 - 35   2024.2   ISSN:2432-8618

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    最近、脂質由来ラジカルや酸化脂質が、細胞死(特にフェロトーシス研究)や炎症反応に密接に関与していることが報告され、注目されている。そのため、酸化脂質、特に脂質過酸化反応に重要な脂質由来ラジカルを標的とした阻害剤が、ラジカル捕捉型抗酸化剤(RTA)として、盛んに研究が進められている。そこで本稿では、脂質ラジカルおよび酸化脂質に対する検出・構造解析技術について記載し、RTAに対する新たな化合物スクリーニング系について、さらに最近の知見について概説する。(著者抄録)

  • 【治療標的がみえてきた 脂質疾患学 がん、不妊症、免疫・神経・皮膚・代謝性疾患のメカニズムから臨床検体による診断、層別化まで】(第2章)脂質解析の新たな視点 酸化脂質解析の新技術

    山田 健一

    実験医学   41 ( 17 )   2785 - 2791   2023.11   ISSN:0288-5514

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    最近,脂質由来ラジカルや酸化脂質が,細胞死(特にフェロトーシス研究)や炎症反応に密接に関与していることが報告され,注目されている.しかしながら,脂質由来ラジカル・酸化脂質の分子そのものの解析は進んでいない.これは,これら分子が,反応性が高く,極微量であり,構造多様性のため,検出に限界があったためと考えられる.しかし,生体内での現象を正しく理解するには,やはり分子そのものを特定しなければならない.そこで本稿では,脂質過酸化連鎖反応中心である脂質由来ラジカルおよび酸化脂質に対する検出・構造解析技術について,最近の知見を概説する.(著者抄録)

  • 酸化脂質解析の新技術

    山田健一

    実験医学 増刊Vol.41-No.17   2023.10

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  • いま知りたい!!治療標的として注目される細胞死フェロトーシス その誘導メカニズムと疾患との関与 概論 フェロトーシス研究の現状

    今井 浩孝, 内田 浩二, 山田 健一

    実験医学   41 ( 8 )   1313 - 1317   2023.5   ISSN:0288-5514

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  • 治療標的として注目される細胞死フェロトーシス その誘導メカニズムと疾患との関与

    今井浩孝、内田浩二、山田健一

    実験医学 Vol.41 No.8   2023.4

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  • Erratum: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity (JCI Insight (2020) 5:9 (e132747) DOI: 10.1172/jci.insight.132747)

    Tadokoro T., Ikeda M., Ide T., Deguchi H., Ikeda S., Okabe K., Ishikita A., Matsushima S., Koumura T., Yamada K.I., Imai H., Tsutsui H.

    JCI Insight   8 ( 6 )   2023.3

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    The authors recently became aware that the Mito-FerroGreen (MFG) used in this study is not an Fe2+ chelator, but instead reduces Fe2+ via conversion to Fe3+. As MFG mediates reduction of Fe2+ and suppresses ferroptosis, the overall conclusions are not affected. For clarity, the authors have removed references to MFG-mediated chelation throughout, updated the Graphical Abstract, and renumbered the reference list to refer to Hirayama et al. (1) when first describing the use of MFG in the Results section. The text and Graphical Abstract have been updated in the HTML version and PDF. The Journal has also published an online version of the original article with the incorrect statements crossed out and the modified text printed in red (Supplemental File, Redaction). The authors regret the errors.

    DOI: 10.1172/jci.insight.169756

    Scopus

  • 【様々な機能を有する新世代の生理活性脂質】最前線 脂質由来ラジカルおよび酸化脂質の検出・構造解析技術

    山田 健一

    ファルマシア   59 ( 1 )   48 - 52   2023.1   ISSN:0014-8601

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  • 脂質由来ラジカル・酸化リン脂質の検出と構造解析

    山田 健一

    生化学   94 ( 3 )   329 - 339   2022.6   ISSN:0037-1017

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    最近,酸化リン脂質が注目されている.リン脂質内の不飽和脂肪酸は,容易に酸化され酸化リン脂質を生成する.あまりにも容易に酸化されるため,これらは単なる副生成物,あるいは不飽和脂肪酸は酸化反応に対する単なるバッファーとも考えられてきた.しかし,最近になって,酸化リン脂質およびその代謝産物が炎症反応などに関与している可能性が報告され,特に,2012年に提唱された細胞死「フェロトーシス」の原因分子として考えられたことで,ますます注目されている.しかしながら,これら酸化リン脂質は反応性が高いために適切に測定する技術が制限されていた.研究を加速するには,やはり分子そのものの検出が必要不可欠であろう.そこで本稿では,脂質過酸化反応の連鎖反応中心である脂質由来ラジカルの検出と構造解析,ならびに酸化リン脂質に対する構造解析技術について記載する.(著者抄録)

  • 酸化脂質と疾患の化学

    山田 健一

    CSJ Current review 39 生体分子と疾患   2021.8

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  • 酸化脂質と加齢黄斑変性疾患

    山田 健一

    実験医学 増刊 Vol.38-No.10   2020.6

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  • 酸化脂質クオリティの可視化と疾患制御

    山田 健一

    医学のあゆみ Vol.269 No.13   2019.6

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  • Recent Developments in Electron Spin Science and Technology in Japan Reviewed

    Toshikazu Nakamura, Tadaaki Ikoma, Ken-Ichi Yamada

    Applied Magnetic Resonance   2018.8

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    DOI: 10.1007/s00723-018-1035-9

  • 酸化還元反応および脂質ラジカルをターゲットとした検出と抑制

    山田 健一

    2018.7

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  • リポクオリティ変化を捉える脂質ラジカル検出プローブの開発と応用

    山田 健一

    実験医学 Vol.36 No.10 (増刊)   2018.6

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  • 脂質クオリティ変化としての脂質ラジカル検出とその抑制

    山田 健一

    リポクオリティ・ニュースレターNo.3   2018.2

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  • 酸化障害の基点としての脂質ラジカルの検出および制御

    山田 健一

    ファルマシア53巻9号   2017.9

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  • 脂質ラジカルをターゲットとした機能性造影剤の開発

    山田 健一

    YAKUGAKU ZASSHI 136(8) 1093―1100   2016.7

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  • Lipid-derived radicals initiate liver cancer development

    Ken-ichi Yamada

    USJI Universities Research Report Vol.52   2016.7

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  • レドックス・フリーラジカル反応検出から可視化へ

    山田 健一

    ファルマシア48巻1号   2012.12

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  • Synthesis and Utilization of α-Substituted Nitroxides. In: Kokorin AI, ed. Nitroxides-Theory, Experiment and Applications.

    Yamasaki T, Mito F, 松岡 悠太, 大和 真由実, Ken-ichi Yamada

    2012.9

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  • 磁気共鳴法を用いた生体内フリーラジカルの検出

    酒井 浄, 内海 英雄, Ken-ichi Yamada

    蛋白質核酸酵素2007増刊号   2007.12

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  • In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries.

    Utsumi H, Yamada K.

    Arch Biochem Biophys   2003.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • Nitric Oxide Society of Japan

  • Society for Free Radical Research JAPAN

  • The Pharmaceutical Society of Japan

  • The Society of Electron Spin Science and Technology

  • The International EPR (ESR) Society

  • Society for Free Radical Biology and Medicine

  • Japanese Society of Chemical Biology

  • Japanese Society for Molecular Imaging

  • Japanese Oil Chemists' Society

  • The Japanese Conference on the Biochemistry of Lipids

  • The Japanese Biochemical Society

  • Association for Redox Research & Development Initiatives

  • The Japanese Society for Cell Death Research

  • THE SOCIETY OF ELECTRON SPIN SCIENCE AND TECHNOLOGY

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  • SOCIETY FOR FREE RADICAL RESEARCH JAPAN

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  • THE PHARMACEUTICAL SOCIETY OF JAPAN

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  • 日本脂質生化学会

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  • 日本生化学会

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  • 日本油化学会

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  • Japanese Society for Molecular Imaging

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  • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

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  • The International EPR (ESR) Society

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  • Society for Free Radical Biology and Medicine

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Committee Memberships

  • Organizer   Domestic

    2023.5 - 2026.12   

  • Organizer   Domestic

    2023.1 - 2025.12   

  • 日本酸化ストレス学会   代議員   Domestic

    2022.8 - 2024.6   

  • 日本酸化ストレス学会   代議員   Domestic

    2020.8 - 2022.6   

  • 日本酸化ストレス学会   代議員  

    2020.8 - 2022.6   

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  • Executive   Domestic

    2019.1 - 2020.12   

  • 電子スピンサイエンス学会   代議員  

    2018.2 - 2022.1   

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  • Steering committee member   Domestic

    2017.4 - 2019.3   

  • 日本油化学会   編集委員   Domestic

    2017.4 - 2019.3   

  • Executive   Domestic

    2017.1 - 2018.12   

  • Executive   Domestic

    2016.1 - 2017.12   

  • Executive   Domestic

    2014.1 - 2015.12   

  • Councilor   Domestic

    2008.6 - Present   

  • 日本酸化ストレス学会   評議員  

    2008.6   

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Academic Activities

  • 座長

    第50回日本毒性学会学術集会  ( 福岡 ) 2024.7

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    Type:Competition, symposium, etc. 

    Number of participants:8,000

  • 座長

    第96回日本生化学会  ( 福岡 ) 2023.10 - 2023.11

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    Type:Competition, symposium, etc. 

    Number of participants:3,000

  • 実行委員長

    第44回生体膜と薬物の相互作用シンポジウム  ( 札幌 ) 2023.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    日本薬学会 第143年会  ( 北海道 ) 2023.3

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    Type:Competition, symposium, etc. 

    Number of participants:8,000

  • 副実行委員長

    第61回電子スピンサイエンス学会  ( 熊本 ) 2022.12

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    日本薬学会第142年会  2022.3

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • オーガナイザー

    第94回日本生化学会大会  2021.11

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    第42回生体膜と薬物の相互作用シンポジウム  ( 東京 ) 2021.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    第63回日本脂質生化学会  ( 東京 ) 2021.6

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    Type:Competition, symposium, etc. 

    Number of participants:400

  • 座長

    第15回日本分子イメージング学会  ( 東京 ) 2021.5

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    第74回日本酸化ストレス学会  ( 東京 ) 2021.5

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    Type:Competition, symposium, etc. 

    Number of participants:400

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • 座長

    第20回日本抗加齢医学会総会  ( 東京 ) 2020.9

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • 座長

    NMR討論会、SEST2019 川崎  ( 川崎 ) 2019.11

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    第72回日本酸化ストレス学会学術集会  ( 札幌 ) 2019.6

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    Type:Competition, symposium, etc. 

    Number of participants:400

  • Free Radical Research International contribution

    2019.2 - Present

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  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • 座長

    第40回生体膜と薬物の相互作用シンポジウム  ( 仙台 ) 2018.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 座長

    第17回次世代を担う若手ファーマ・バイオフォーラム  ( 熊本 ) 2018.9

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 世話人

    第16回レドックス・ライフイノベーションシンポジウム  ( 福岡 ) 2018.8

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • 座長

    第71回日本酸化ストレス学会学術集会  ( 京都 ) 2018.5

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    Type:Competition, symposium, etc. 

    Number of participants:500

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • Journal of Oleo science International contribution

    2016.4 - Present

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  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • 世話人

    第17回ESRフォーラム研究会  ( 福岡 ) 2013.7

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    Type:Competition, symposium, etc. 

    Number of participants:50

  • Advisory Committee International contribution

    ( Japan ) 2011.11

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    Type:Competition, symposium, etc. 

    Number of participants:150

  • 実行委員

    第64回日本酸化ストレス学会学術集会  ( 北海道 ) 2011.7

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    Type:Competition, symposium, etc. 

    Number of participants:500

  • 実行委員

    第48回電子スピンサイエンス学会年会  ( 神戸 ) 2009.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 実行委員

    第62回日本酸化ストレス学会学術集会  ( 福岡 ) 2009.6

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 年会実行委員

    第47回電子スピンサイエンス学会年会  ( 福岡 ) 2008.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Organizing Committee International contribution

    A Joint Conference of 13th In Vivo EPR Spectroscopy and Imaging / 10th International EPR Spin Trapping/Spin Labeling  ( Japan ) 2008.9

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 年会実行委員

    第42回電子スピンサイエンス学会年会  ( 広島 ) 2003.10 - Present

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Secretariat International contribution

    The 10th International Workshop on Bio-Medical ESR Spectroscopy and Imaging  ( Fukuoka Japan ) 2003.4 - Present

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    Type:Competition, symposium, etc. 

    Number of participants:100

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Research Projects

  • New functions by phospholipid oxidation modification

    Grant number:24K22024  2024.6 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Grant type:Scientific research funding

    CiNii Research

  • Diversity of oxidized lipids and their functional understanding

    Grant number:23H05481  2023 - 2027

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • Comprehensive analysis and evaluation of oxidized lipids reacting with cysteine-containing proteins

    Grant number:22H05572  2022 - 2023

    Japan Society for the Promotion of Science・Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research  Grant-in-Aid for Transformative Research Areas (A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • Development of therapeutics based on ferroptosis in myocardial injury

    Grant number:20K08426  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ide Tomomi

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    Grant type:Scientific research funding

    Ferrotosis is a programmed cell death proposed by Dixon et al. in 2012 as an iron-dependent cell death. With this foundational study, we have identified the role of ferrotosis in doxorubicin cardiotoxicity, the molecular mechanisms of induction, and the potential of targeting ferrotosis as a therapeutic strategy. In doxorubicin-induced myocardial injury, we found that doxorubicin accumulates in mitochondria in a mitochondrial DNA copy number-dependent manner, resulting in an iron overload state due to impaired heme synthesis in mitochondria, leading to increased lipid peroxide and cardiac dysfunction due to ferotosis In addition, the study showed that aminolevulinic acid administration caused a decrease in the amount of iron in the mitochondria. Furthermore, it was revealed that aminolevulinic acid administration can prevent the disease.

    CiNii Research

  • Comprehensive understanding of oxidized lipids involved in disease induction

    Grant number:20H00493  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • Comprehensive study on wide-area disasters due to typhoon no.19 and 21 in 2019

    Grant number:19K24678  2019.12 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Special Purposes

    Nihei Yasuo

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    Grant type:Scientific research funding

    This study aims to clarify the damage situation and mechanism of wide-area disasters caused by Typhoon no. 19 and Typhoon no. 21 (low pressure) in 2019. In this study, we conducted five themes: 1) the meteorological phenomenon of heavy rain and runoff caused by typhoons and low pressure systems, 2) the mechanism of flood disasters over a wide area, 3) the mechanism of frequent landslide disasters and soil structure destruction, 4) the actual damage caused by storm surges, wave and strong wind, and 5) the actual situation of residents' evacuation behavior. A report on these results was prepared and published, and proposals for future disaster countermeasures were compiled in the report.

  • 新たな細胞死フェロトーシスにおける脂質ラジカルの関与

    Grant number:18K19405  2018 - 2019

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 血管性認知症発症・進展抑制剤

    2018

    橋渡し研究・新規開発シーズ(シーズA 九州大学公募)

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 次世代メタボローム解析技術開発と応用

    Grant number:17H06304  2017 - 2021

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

    馬場 健史, 山田 健一, 和泉 自泰, 相馬 悠希

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    メタボローム分析における定量値の取得を可能にし,代謝アダプテーション解析に資する次世代メタボローム解析基盤技術の構築に取り組んだ.各種クロマトグラフィー質量分析系を用いた定量メタボローム分析系の開発に成功した.また,LCと各種検出器を組み合わせた個別成分定量分析系も開発した.さらに,質量分析における定量解析に必要となる安定同位体ラベル化内部標準群,微量成分の高感度定量分析用プローブの開発,定量メタボローム分析用データ解析システムの開発などにも成功した.目的とした定量メタボローム解析基盤技術を構築し,それらを用いた代謝アダプテーションの応用研究を領域内外の共同研究者と多数実施した.

    CiNii Research

  • ラジカロミクス技術開発

    Grant number:17H03977  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 加齢黄斑変性発症・進展抑制剤

    2017

    橋渡し研究・新規開発シーズ(シーズA 九州大学公募)

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 還元ストレス検出蛍光プローブ開発

    Grant number:16K15109  2016 - 2017

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 生体内脂質クオリティ変化としての脂質ラジカル蛍光検出・構造解析

    Grant number:16H01363  2016 - 2017

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 脂質ラジカルの異なる階層間での情報統合と疾患モデルへの適用

    Grant number:24390011  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 環境・脂質ラジカル応答型蛍光化合物の開発と評価

    Grant number:24659020  2012 - 2013

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • OMRIを用いた酸化ストレス疾患モデルにおけるレドックス動態の画像解析研究

    Grant number:22249003  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 脂質ラジカル検出手法開発

    Grant number:22790038  2010 - 2011

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アルツハイマー病の次世代無侵襲画像診断手法の開発

    Grant number:19689002  2007 - 2009

    科学研究費助成事業  若手研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 異核種同時分離画像化法による生体内レドックス動態解析

    Grant number:17790036  2005 - 2006

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 生体計測ESRIを用いた疾患モデル動物でのフリーラジカル動態解析

    Grant number:15087206  2003 - 2006

    科学研究費助成事業  特定領域研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • プロトン・電子2重共鳴法を用いた14N,15N標識スピンプローブの生体内分離画像

    Grant number:15790029  2003 - 2004

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 生体ラジカル二重共鳴画像解析用共振デバイスと画像化システムの開発

    Grant number:14657571  2002 - 2003

    科学研究費助成事業  萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 酸化ストレス性疾患を対象とするESRI・MRI融合型画像解析装置の開発

    Grant number:13357019  2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

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Class subject

  • 物理薬学Ⅱ

    2024.12 - 2025.2   Winter quarter

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    2024.6 - 2024.8   Summer quarter

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    2024.4 - 2024.9   First semester

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    2024.4 - 2024.9   First semester

  • 物理化学的測定法

    2024.4 - 2024.6   Spring quarter

  • 創薬科学総論Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 物理薬学Ⅰ

    2024.4 - 2024.6   Spring quarter

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    2024.4 - 2024.6   Spring quarter

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    2024.4 - 2024.6   Spring quarter

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    2023.12 - 2024.2   Winter quarter

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    2023.10 - 2023.12   Fall quarter

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    2023.10 - 2023.12   Fall quarter

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    2023.6 - 2023.8   Summer quarter

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    2023.6 - 2023.8   Summer quarter

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    2023.4 - 2024.3   Full year

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    2023.4 - 2024.3   Full year

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    2023.4 - 2023.9   First semester

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    2023.4 - 2023.9   First semester

  • 機能性分子の設計と機器開発

    2023.4 - 2023.9   First semester

  • 物理薬学Ⅰ

    2023.4 - 2023.6   Spring quarter

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    2023.4 - 2023.6   Spring quarter

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    2022.12 - 2023.2   Winter quarter

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    2022.12 - 2023.2   Winter quarter

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    2022.10 - 2022.12   Fall quarter

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    2022.10 - 2022.12   Fall quarter

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    2022.10 - 2022.12   Fall quarter

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    2022.10 - 2022.12   Fall quarter

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    2022.6 - 2022.8   Summer quarter

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    2022.6 - 2022.8   Summer quarter

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    2022.4 - 2023.3   Full year

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    2022.4 - 2023.3   Full year

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    2022.4 - 2022.9   First semester

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    2022.4 - 2022.6   Spring quarter

  • 創薬科学総論Ⅰ

    2022.4 - 2022.6   Spring quarter

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    2021.12 - 2022.2   Winter quarter

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    2021.12 - 2022.2   Winter quarter

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    2021.10 - 2021.12   Fall quarter

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    2021.10 - 2021.12   Fall quarter

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    2021.10 - 2021.12   Fall quarter

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    2021.6 - 2021.8   Summer quarter

  • 創薬科学総論Ⅱ

    2021.6 - 2021.8   Summer quarter

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    2021.4 - 2022.3   Full year

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    2021.4 - 2022.3   Full year

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    2021.4 - 2021.9   First semester

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    2021.4 - 2021.9   First semester

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    2021.4 - 2021.9   First semester

  • 物理薬学Ⅰ

    2021.4 - 2021.6   Spring quarter

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    2021.4 - 2021.6   Spring quarter

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    2020.12 - 2021.2   Winter quarter

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    2020.12 - 2021.2   Winter quarter

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    2020.10 - 2020.12   Fall quarter

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    2020.10 - 2020.12   Fall quarter

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    2020.10 - 2020.12   Fall quarter

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    2020.10 - 2020.12   Fall quarter

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    2020.6 - 2020.8   Summer quarter

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    2020.6 - 2020.8   Summer quarter

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    2020.4 - 2021.3   Full year

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    2020.4 - 2021.3   Full year

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    2020.4 - 2021.3   Full year

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    2020.4 - 2021.3   Full year

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    2020.4 - 2021.3   Full year

  • 社会薬学

    2020.4 - 2020.9   First semester

  • 社会薬学

    2020.4 - 2020.9   First semester

  • 物理化学的測定法

    2020.4 - 2020.9   First semester

  • 創薬科学総論Ⅰ

    2020.4 - 2020.6   Spring quarter

  • 創薬科学総論Ⅰ

    2020.4 - 2020.6   Spring quarter

  • 物理薬学Ⅰ

    2020.4 - 2020.6   Spring quarter

  • 物理薬学Ⅰ

    2020.4 - 2020.6   Spring quarter

  • 薬学少人数ゼミナール

    2019.12 - 2020.2   Winter quarter

  • 物理薬学Ⅱ

    2019.12 - 2020.2   Winter quarter

  • 物理薬学Ⅱ

    2019.12 - 2020.2   Winter quarter

  • 放射化学Ⅰ

    2019.10 - 2019.12   Fall quarter

  • 物理化学演習

    2019.10 - 2019.12   Fall quarter

  • 薬学少人数ゼミナール

    2019.10 - 2019.12   Fall quarter

  • 物理化学演習

    2019.10 - 2019.12   Fall quarter

  • 物理薬学研究

    2019.4 - 2020.3   Full year

  • 物理薬学研究

    2019.4 - 2020.3   Full year

  • 卒業研究

    2019.4 - 2020.3   Full year

  • 物理化学的測定法

    2019.4 - 2019.9   First semester

  • 機能性分子の設計と機器開発

    2019.4 - 2019.9   First semester

  • 物理薬学Ⅰ

    2019.4 - 2019.6   Spring quarter

  • 物理薬学Ⅰ

    2019.4 - 2019.6   Spring quarter

  • 創薬化学総論I

    2019.4 - 2019.6   Spring quarter

  • 物理薬学Ⅱ

    2018.12 - 2019.2   Winter quarter

  • 物理薬学Ⅱ

    2018.12 - 2019.2   Winter quarter

  • 物理薬学研究

    2018.12 - 2019.2   Winter quarter

  • 物理薬学研究

    2018.12 - 2019.2   Winter quarter

  • 薬学少人数ゼミナール

    2018.10 - 2019.3   Second semester

  • 物理化学演習

    2018.10 - 2018.12   Fall quarter

  • 物理化学演習

    2018.10 - 2018.12   Fall quarter

  • 卒業研究

    2018.4 - 2019.3   Full year

  • 先端研究実験I

    2018.4 - 2019.3   Full year

  • 先端研究実験II

    2018.4 - 2019.3   Full year

  • 薬学特別実習

    2018.4 - 2019.3   Full year

  • 物理薬学演習Ⅰ

    2018.4 - 2018.9   First semester

  • 物理薬学教育指導実習

    2018.4 - 2018.9   First semester

  • 創薬化学総論I

    2018.4 - 2018.9   First semester

  • 物理薬学演習Ⅱ

    2018.4 - 2018.9   First semester

  • 薬学基礎実習Ⅱ

    2018.4 - 2018.9   First semester

  • 物理化学的測定法

    2018.4 - 2018.9   First semester

  • 物理薬学Ⅰ

    2018.4 - 2018.6   Spring quarter

  • 物理薬学Ⅰ

    2018.4 - 2018.6   Spring quarter

  • 物理薬学研究

    2017.12 - 2018.2   Winter quarter

  • 物理薬学Ⅱ

    2017.12 - 2018.2   Winter quarter

  • 薬学少人数ゼミナール

    2017.10 - 2018.3   Second semester

  • 卒業研究

    2017.4 - 2018.3   Full year

  • 先端研究実験I

    2017.4 - 2018.3   Full year

  • 先端研究実験II

    2017.4 - 2018.3   Full year

  • 薬学特別実習

    2017.4 - 2018.3   Full year

  • 物理化学演習

    2017.4 - 2017.9   First semester

  • 物理薬学演習Ⅰ

    2017.4 - 2017.9   First semester

  • 物理薬学教育指導実習

    2017.4 - 2017.9   First semester

  • 創薬化学総論I

    2017.4 - 2017.9   First semester

  • 物理薬学演習Ⅱ

    2017.4 - 2017.9   First semester

  • 薬学基礎実習Ⅱ

    2017.4 - 2017.9   First semester

  • 物理化学的測定法

    2017.4 - 2017.9   First semester

  • 機能性分子の設計と機器開発

    2017.4 - 2017.9   First semester

  • 物理薬学Ⅰ

    2017.4 - 2017.6   Spring quarter

  • 薬学少人数ゼミナール

    2016.10 - 2017.3   Second semester

  • 物理薬学研究

    2016.10 - 2017.3   Second semester

  • 卒業研究

    2016.4 - 2017.3   Full year

  • 先端研究実験I

    2016.4 - 2017.3   Full year

  • 先端研究実験II

    2016.4 - 2017.3   Full year

  • 薬学特別実習

    2016.4 - 2017.3   Full year

  • 薬学基礎実習II

    2016.4 - 2016.9   First semester

  • 物理化学演習

    2016.4 - 2016.9   First semester

  • 物理薬学I

    2016.4 - 2016.9   First semester

  • 物理化学的測定法

    2016.4 - 2016.9   First semester

  • 物理薬学演習II

    2016.4 - 2016.9   First semester

  • 物理薬学演習I

    2016.4 - 2016.9   First semester

  • 物理薬学教育指導実習

    2016.4 - 2016.9   First semester

  • 物理薬学II

    2016.4 - 2016.9   First semester

  • 創薬化学総論I

    2016.4 - 2016.9   First semester

  • 薬学少人数ゼミナール

    2015.10 - 2016.3   Second semester

  • 物理薬学研究

    2015.10 - 2016.3   Second semester

  • 物理薬学II

    2015.10 - 2016.3   Second semester

  • 物理薬学研究

    2015.10 - 2016.3   Second semester

  • 先端研究実験I

    2015.4 - 2016.3   Full year

  • 卒業研究

    2015.4 - 2016.3   Full year

  • 薬学特別実習

    2015.4 - 2016.3   Full year

  • 先端研究実験II

    2015.4 - 2016.3   Full year

  • 物理薬学I

    2015.4 - 2015.9   First semester

  • 物理薬学系教育指導実習

    2015.4 - 2015.9   First semester

  • 薬学基礎実習II

    2015.4 - 2015.9   First semester

  • 創薬化学総論I

    2015.4 - 2015.9   First semester

  • 物理薬学教育指導実習

    2015.4 - 2015.9   First semester

  • 物理薬学演習I

    2015.4 - 2015.9   First semester

  • 物理薬学演習II

    2015.4 - 2015.9   First semester

  • 機能性分子の設計と機器開発

    2015.4 - 2015.9   First semester

  • 物理化学的測定法

    2015.4 - 2015.9   First semester

  • 物理化学演習

    2015.4 - 2015.9   First semester

  • 物理薬学研究

    2014.10 - 2015.3   Second semester

  • 物理薬学II

    2014.10 - 2015.3   Second semester

  • 物理薬学研究

    2014.10 - 2015.3   Second semester

  • 薬学少人数ゼミナール

    2014.10 - 2015.3   Second semester

  • 先端研究実験I

    2014.4 - 2015.3   Full year

  • 卒業研究

    2014.4 - 2015.3   Full year

  • 薬学特別実習

    2014.4 - 2015.3   Full year

  • 先端研究実験II

    2014.4 - 2015.3   Full year

  • 物理薬学系教育指導実習

    2014.4 - 2014.9   First semester

  • 創薬化学総論I

    2014.4 - 2014.9   First semester

  • 物理薬学教育指導実習

    2014.4 - 2014.9   First semester

  • 物理薬学演習II

    2014.4 - 2014.9   First semester

  • 薬学基礎実習II

    2014.4 - 2014.9   First semester

  • 基礎物理実験・安全教育

    2014.4 - 2014.9   First semester

  • 物理化学演習

    2014.4 - 2014.9   First semester

  • 物理薬学演習I

    2014.4 - 2014.9   First semester

  • 物理化学的測定法

    2014.4 - 2014.9   First semester

  • 物理薬学研究

    2013.10 - 2014.3   Second semester

  • 物理薬学研究

    2013.10 - 2014.3   Second semester

  • 薬学少人数ゼミナール

    2013.10 - 2014.3   Second semester

  • 物理薬学I

    2013.10 - 2014.3   Second semester

  • 量子化学

    2013.10 - 2014.3   Second semester

  • 先端研究実験I

    2013.4 - 2014.3   Full year

  • 卒業研究

    2013.4 - 2014.3   Full year

  • 薬学特別実習

    2013.4 - 2014.3   Full year

  • 先端研究実験II

    2013.4 - 2014.3   Full year

  • 物理薬学系教育指導実習

    2013.4 - 2013.9   First semester

  • 物理薬学教育指導実習

    2013.4 - 2013.9   First semester

  • 物理薬学演習II

    2013.4 - 2013.9   First semester

  • 薬学基礎実習II

    2013.4 - 2013.9   First semester

  • 基礎物理実験・安全教育

    2013.4 - 2013.9   First semester

  • 物理化学演習

    2013.4 - 2013.9   First semester

  • 物理薬学演習I

    2013.4 - 2013.9   First semester

  • 物理化学的測定法

    2013.4 - 2013.9   First semester

  • 機能性分子の設計と機器開発

    2013.4 - 2013.9   First semester

  • 物理薬学I

    2012.10 - 2013.3   Second semester

  • 物理薬学研究

    2012.10 - 2013.3   Second semester

  • 薬学少人数ゼミナール

    2012.10 - 2013.3   Second semester

  • 物理薬学研究

    2012.10 - 2013.3   Second semester

  • 量子化学

    2012.10 - 2013.3   Second semester

  • 生物物理化学

    2012.10 - 2013.3   Second semester

  • 物理薬学演習I

    2012.4 - 2012.9   First semester

  • 薬学基礎実習II

    2012.4 - 2012.9   First semester

  • 基礎物理実験・安全教育

    2012.4 - 2012.9   First semester

  • 物理薬学系教育指導実習

    2012.4 - 2012.9   First semester

  • 機能性分子の設計と機器開発

    2012.4 - 2012.9   First semester

  • 物理化学的測定法

    2012.4 - 2012.9   First semester

  • 物理薬学演習II

    2012.4 - 2012.9   First semester

  • 生物物理化学

    2011.10 - 2012.3   Second semester

  • 物理薬学研究

    2011.10 - 2012.3   Second semester

  • 薬学少人数ゼミナール

    2011.10 - 2012.3   Second semester

  • 物理薬学研究

    2011.10 - 2012.3   Second semester

  • 物理薬学I

    2011.10 - 2012.3   Second semester

  • 物理薬学演習II

    2011.4 - 2011.9   First semester

  • 薬学基礎実習II

    2011.4 - 2011.9   First semester

  • 基礎物理実験・安全教育

    2011.4 - 2011.9   First semester

  • 物理薬学演習I

    2011.4 - 2011.9   First semester

  • 物理薬学系教育指導実習

    2011.4 - 2011.9   First semester

  • 物理化学的測定法

    2011.4 - 2011.9   First semester

  • 物理薬学I

    2010.10 - 2011.3   Second semester

  • 物理薬学研究

    2010.10 - 2011.3   Second semester

  • 薬学少人数ゼミナール

    2010.10 - 2011.3   Second semester

  • 生物物理化学

    2010.10 - 2011.3   Second semester

  • 基礎物理実験・安全教育

    2010.4 - 2010.9   First semester

  • 薬学基礎実習II

    2010.4 - 2010.9   First semester

  • 生物物理化学

    2009.10 - 2010.3   Second semester

  • 物理薬学I

    2009.10 - 2010.3   Second semester

  • 物理化学演習

    2009.4 - 2009.9   First semester

  • 物理薬学I

    2008.10 - 2009.3   Second semester

  • 生物物理化学

    2008.10 - 2009.3   Second semester

  • 物理化学演習

    2008.4 - 2008.9   First semester

  • 自然科学総合実験

    2008.4 - 2008.9   First semester

  • 機能分子解析学特論

    2007.10 - 2008.3   Second semester

  • 生物物理化学

    2007.10 - 2008.3   Second semester

  • 物理薬学I

    2007.10 - 2008.3   Second semester

  • 自然科学総合実験

    2007.4 - 2007.9   First semester

  • 物理薬学I

    2006.10 - 2007.3   Second semester

  • 生物物理化学

    2006.10 - 2007.3   Second semester

▼display all

FD Participation

  • 2024.7   Role:Participation   Title:第5回創薬産学官連携セミナー(新モダリティ)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.11   Role:Participation   Title:第2回部局FD講演会「機関間連携」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role:Participation   Title:令和5年度4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role:Participation   Title:学生の多様性に対応した教育とは:障害学生への合理的配慮を中心に

    Organizer:University-wide

  • 2022.4   Role:Participation   Title:学生の多様性に対応した教育とは:障害学生への合理的配慮を中心に

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role:Participation   Title:第3回創薬産学官連携セミナー(感染症研究拠点WG共催)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Role:Participation   Title:次世代研究者挑戦的研究プログラム説明会

    Organizer:University-wide

  • 2021.7   Role:Participation   Title:生体防御医学研究所FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.7   Role:Participation   Title:生体防御医学研究所FD(科学論文出版関連)「ハゲタカジャーナルの実態と対策」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.7   Role:Participation   Title:COILとは?九大農学部&共創学部の実施例

    Organizer:University-wide

  • 2021.5   Role:Participation   Title:薬学FD企画(第2回創薬産学官連携セミナー)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.5   Role:Participation   Title:第2回創薬産学官連携セミナー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.2   Role:Participation   Title:FD講演会(浦野泰照先生・佐藤陽治先生)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.2   Role:Participation   Title:創薬産学官連携セミナー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.9   Role:Participation   Title:M2B学習支援システム講習会(オンライン開催)◇初級編・中級編◇10:00~12:00

    Organizer:University-wide

  • 2020.9   Role:Participation   Title:全学FD 「M2B学習支援システム講習会」初級・中級編

    Organizer:University-wide

  • 2019.3   Role:Participation   Title:3ポリシー見直し方針に関する全学FD

    Organizer:University-wide

  • 2019.3   Role:Participation   Title:平成33年度入学者選抜改革「一般選抜における主体性評価について」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.11   Role:Participation   Title:研究分析ツール「SciVal」及び研究者プロファイリングツール「Pure」い関する説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role:Participation   Title:本学の男女共同参画の取り組みについて

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.7   Role:Participation   Title:平成33年度入学者選抜改革 【九州大学新入試QUBE】 ~各学部での検討にむけた情報提供~

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.5   Role:Participation   Title:総合的創薬ソリューションプロバイダーによる創薬研究支援の新たな形 アクセリード株式会社 麻生 和義 様

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role:Participation   Title:外国人留学生の受入と管理(情報管理、輸出管理)について 国際法務室 研究推進専門員 佐藤 弘基 氏

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.4   Role:Participation   Title:Webを用いた電子ポートフォリオの使用方法の概要について FujiZerox社担当者

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.6   Role:Participation   Title:製薬業界の環境変化を受けた今後のMR活動とメディカルアフェアーズの確立について_久米龍一 先生 (シオノギ製薬 常務執行役員 医薬営業本部長)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.2   Role:Participation   Title:Education in Chemistry at Nanyang Technological University_千葉俊介先生 (NTU, シンガポール)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.7   Role:Participation   Title:飲酒 運転の撲滅にむけた警察講師による講話会_福岡県警察本部 交通企画課 講師

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.3   Role:Participation   Title:学生のメンタルヘルスの現状と対応

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.4   Role:Participation   Title:薬局実務実習指導評価講習会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.10   Role:Participation   Title:OSCE評価者講習会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Other educational activity and Special note

  • 2023  Class Teacher 

  • 2019  Class Teacher 

  • 2018  Class Teacher 

  • 2017  Class Teacher 

  • 2016  Class Teacher 

  • 2015  Class Teacher 

  • 2014  Class Teacher 

  • 2013  Class Teacher 

  • 2013  Coaching of Students' Association 

  • 2012  Class Teacher 

  • 2012  Coaching of Students' Association 

  • 2011  Coaching of Students' Association 

  • 2010  Coaching of Students' Association 

  • 2009  Coaching of Students' Association 

  • 2008  Coaching of Students' Association 

▼display all

Social Activities

  • 出前講義

    福大付属大濠高校  2024.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Visiting lecture

  • 出前講義

    広島市立基町高校  2024.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Visiting lecture

  • 出前講義

    明善高校  2024.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Visiting lecture

  • 薬剤師国家試験問題検討委員

    2023 - 2024

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    薬剤師国家試験問題検討委員

  • 九大薬友会 副会長

    2023 - 2024

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    九大薬友会 副会長

  • 出前講義

    伝習館高校  2022.11

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    筑紫女学園  2022.10

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    山口高校  2022.9

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    広島高校  2022.8

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    甲南高校(鹿児島)  2022.8

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    福岡高校  2022.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    福岡県立城南高校  2022.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    ノートルダム清心  2022.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    明治学園  2022.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出前講義

    福岡高校  2022.6

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九大薬友会 副会長

    2022

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    九大薬友会 副会長

  • よか薬会 理事

    2022

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    よか薬会 理事

  • 薬剤師国家試験問題検討委員

    2022

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    薬剤師国家試験問題検討委員

  • 招待講演

    中村学園女子高等学校  2021.12

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • よか薬会 理事

    2021

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    よか薬会 理事

  • 九大薬友会 副会長

    2021

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    九大薬友会 副会長

  • 薬剤師国家試験問題検討委員

    2021

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    薬剤師国家試験問題検討委員

  • よか薬会 理事

    2020

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    よか薬会 理事

  • 薬剤師国家試験問題検討委員

    2020

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    薬剤師国家試験問題検討委員

  • 九大薬友会 副会長

    2020

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    九大薬友会 副会長

  • 模擬講義、研究室訪問

    佐賀県立唐津東高等学校  2019.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九大薬友会 副会長

    2019

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    九大薬友会 副会長

  • 薬剤師国家試験問題検討委員

    2019

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    薬剤師国家試験問題検討委員

  • よか薬会 理事

    2019

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    よか薬会 理事

  • 九大薬友会 副会長

    2018

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    九大薬友会 副会長

  • 薬剤師国家試験問題検討委員

    2018

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    薬剤師国家試験問題検討委員

  • 薬剤師国家試験問題検討委員

    2017

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    薬剤師国家試験問題検討委員

  • よか薬会 理事

    2017

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    よか薬会 理事

  • よか薬会 理事

    2016

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    よか薬会 理事

  • 第12回ESR入門セミナー 講師

    2016

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    第12回ESR入門セミナー 講師

  • 第11回ESR入門セミナー 講師

    2015

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    第11回ESR入門セミナー 講師

  • 第8回ESR入門セミナー 講師

    2012

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    第8回ESR入門セミナー 講師

  • 第8回 ESR夏の学校 講師

    2010

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    第8回 ESR夏の学校 講師

  • 日本薬学会CBT問題精選委員

    2008

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    日本薬学会CBT問題精選委員

  • 第4回ESR入門セミナー 講師

    2008

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    第4回ESR入門セミナー 講師

  • 日本薬学会CBT問題精選委員

    2007

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    日本薬学会CBT問題精選委員

  • 日本薬学会CBT問題精選委員

    2006

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    日本薬学会CBT問題精選委員

▼display all

Media Coverage

  • 米で臨床試験実施目指す Newspaper, magazine

    日本経済新聞・朝刊/WEB版  2024.6

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    九大発のスタートアップ企業

  • 米国ボストンとバイオ連携へ世界から選ばれる福岡県への挑戦 Newspaper, magazine

    西日本新聞・朝刊/WEB版  2023.11

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    九大発のスタートアップ企業

  • 挑む福岡バイオ Newspaper, magazine

    西日本新聞・朝刊  https://bio.nikkeibp.co.jp/atcl/column/16/021500017/101700306/  2023.11

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    九大発のスタートアップ企業

  • フェリクス、酸化脂質の検出技術で未熟児網膜症向けに低分子薬を開発中 Internet

    日経バイオテク  https://bio.nikkeibp.co.jp/atcl/column/16/021500017/101700306/  2023.10

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    九大発のスタートアップ企業

  • BIO2023、じわり高まる日本のスタートアップの存在感 Internet

    日経バイオテク  https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/20/10833/  2023.6

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    九大発のスタートアップ企業

  • プログラム細胞死「フェロトーシス」に着目した創薬 Newspaper, magazine

    米国製薬業界週報 第945号  2023.4

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    九大発のスタートアップ企業

  • 県支援の創薬 スタートアップ資金3億円を調達 Newspaper, magazine

    西日本新聞  2022.10

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    九大発のスタートアップ企業

  • 九大発のスタートアップ企業 Newspaper, magazine

    毎日新聞  2022.10

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    九大発のスタートアップ企業

  • 県支援の創薬スタートアップ Newspaper, magazine

    西日本新聞  2022.10

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    県支援の創薬スタートアップ

  • 九州大学発のフェリクス、3億円調達 小児向け新薬開発 Newspaper, magazine

    日本経済新聞  2022.9

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    九州大学発のフェリクス、3億円調達 小児向け新薬開発

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Acceptance of Foreign Researchers, etc.

  • コンケン大学

    Acceptance period: 2024.6 - 2024.9   (Period):1 month or more

    Nationality:Thailand

    Business entity:Ministry of education

  • マヒドン大学

    Acceptance period: 2023.6 - 2023.9   (Period):1 month or more

    Nationality:Thailand

    Business entity:Ministry of education

  • マラヤ大学

    Acceptance period: 2023.3 - 2024.4   (Period):2weeks to less than 1 month

    Nationality:Malaysia

    Business entity:On-campus funds

  • マヒドン大学

    Acceptance period: 2022.10 - 2023.9   (Period):1 month or more

    Nationality:Thailand

    Business entity:Foreign governments, foreign research institutes, international organizations

  • マラヤ大学

    Acceptance period: 2020.1 - 2020.2   (Period):1 month or more

    Nationality:Malaysia

    Business entity:On-campus funds

  • マラヤ大学

    Acceptance period: 2019.1 - 2019.2   (Period):1 month or more

    Nationality:Malaysia

    Business entity:On-campus funds

  • チュラロンコン大学

    Acceptance period: 2017.12 - 2018.1   (Period):1 month or more

    Nationality:Thailand

    Business entity:On-campus funds

  • チュラロンコン大学

    Acceptance period: 2016.12 - 2017.3   (Period):1 month or more

    Nationality:Thailand

    Business entity:Other

▼display all

Travel Abroad

  • 2024.7

    Staying countory name 1:Thailand   Staying institution name 1:Mahidol University

  • 2024.5

    Staying countory name 1:Thailand   Staying institution name 1:Mahidol University

  • 2023.11

    Staying countory name 1:Italy   Staying institution name 1:Milano University

    Staying countory name 2:Croatia   Staying institution name 2:Dubrovnik University

  • 2023.9

    Staying countory name 1:United States   Staying institution name 1:Harvard Medical School

    Staying countory name 2:United States   Staying institution name 2:Department of Medical Genetics

  • 2023.8

    Staying countory name 1:Thailand   Staying institution name 1:Mahidol University

  • 2019.6

    Staying countory name 1:Malaysia   Staying institution name 1:Maraya University

▼display all