Updated on 2024/10/04

Information

 

写真a

 
AKITA TAKEYUKI
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Lecturer
Faculty of Pharmaceutical Sciences Drug Discovery and Evolution Center（Joint Appointment）
Title
Lecturer
Contact information
メールアドレス
Tel
0926426592
Profile
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Research Areas

  • Life Science / Pharmaceutical chemistry and drug development sciences

  • Life Science / Pharmaceutical analytical chemistry and physicochemistry

  • Natural Science / Magnetism, superconductivity and strongly correlated systems

  • Nanotechnology/Materials / Functional solid state chemistry

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

Degree

  • Doctor of Sciences

Research Interests・Research Keywords

  • Research theme：Development of Novel Fluorescence Derivatization Reagents for Highly Sensitive HPLC Analyses

    Keyword：Chiral, HPLC, Fluoresence, Derivatization reagent

    Research period： 2016.6

  • Research theme：Deveropment of novel packing materials for highly selective HPLC chiral analyses

    Keyword：HPLC, stationary phase, chiral

    Research period： 2016.6

  • Research theme：Magnetic control of chemical reactions with SPIONs

    Keyword：Magnetic control of chemical reactions

    Research period： 2009.4 - 2017.3

  • Research theme：Photoresponsible Super-high Spin molecules

    Keyword：molecular magnetism, high spin, dendorimar, polymer, diazo, carbene, radical

    Research period： 2000.4 - 2017.3

  • Research theme：Control of Intermolecular Spin Interaction by Hydrogen Bonds

    Keyword：molecular magnetism, hydrogen bond, spin interaction, supramolecule, radical

    Research period： 1997.4 - 2017.3

Papers

  • Analysis of Alanine and Serine Enantiomers in Vinegars Using a Meter-long High-resolution Enantioselective Column Reviewed

    ISHII Chiharu, KOGA Yumemi, FUJII Akira, AKITA Takeyuki, MITA Masashi, NAGANO Masanobu, HAMASE Kenji

    BUNSEKI KAGAKU   73 ( 7.8 )   337 - 344   2024.7   （ ISSN:05251931 ）

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japan Society for Analytical Chemistry  

    <p>Over the past few decades, D-amino acids, the minor enantiomers of widely present L-amino acids, have been found in mammals, and several D-forms including D-serine (D-Ser) and D-alanine (D-Ala) are expected as new physiologically-active molecules. Since orally ingested D-amino acids are transferred to mammalian tissues, foodstuffs and beverages naturally containing D-amino acids would be useful for human health. Therefore, the determination of chiral amino acids in various foods/beverages, especially in fermented products, is expected for the discovery of functional materials. However, the precise determination of trace levels of D-amino acids is a challenging task, and continuous improvement of both the enantiomer separation and the chemo-selectivity of the analytical methods is required. Regarding these issues, extension of the column length is one of the effective approaches. In the present study, the enantioselective separations of Ala and Ser using long enantioselective columns (the total lengths were 250, 500, 750 and 1000 mm) were evaluated. As a result, using a column of 1000-mm length, the resolution values for the Ala and Ser enantiomers were improved by 1.5–1.6 times compared to the results obtained using a 250-mm column. The effective theoretical plate numbers for L-Ala and L-Ser were also improved by 2.2–2.3 times. By using the chiral HPLC method equipped with the meter-long enantioselective column, the Ala and Ser enantiomers in various vinegar samples were successfully determined. In the Japanese black vinegar samples produced by traditional manufacturing processes, relatively high amounts of D-enantiomers were found. Especially, in the black vinegars made in Kagoshima prefecture, the concentrations of D-Ala and D-Ser were 1.79–5.58 μmol mL<sup>−1</sup> and 0.12–0.89 μmol mL<sup>−1</sup>, respectively. Additionally, the significant increase (<i>p</i> < 0.05) in the D-Ser amounts with the extension of the fermentation/aging period was demonstrated, indicating that the long-term fermented black vinegars are useful as functional materials. </p>

    DOI： 10.2116/bunsekikagaku.73.337

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  • Enantioselective three-dimensional high-performance liquid chromatographic determination of amino acids in the Hayabusa2 returned samples from the asteroid Ryugu Reviewed International coauthorship International journal

    Aogu Furusho, Chiharu Ishii, Takeyuki Akita, Mai Oyaide, Masashi Mita, Hiroshi Naraoka, Yoshinori Takano, Jason P. Dworkin, Yasuhiro Oba, Toshiki Koga, Kazuhiko Fukushima, Dan Aoki, Minako Hashiguchi, Hajime Mita, Yoshito Chikaraishi, Naohiko Ohkouchi, Nanako O. Ogawa, Saburo Sakai, Daniel P. Glavin, Jamie E. Elsila, Eric T. Parker, José C. Aponte, Hannah L. McLain, Francois Regis Orthous-Daunay, Véronique Vuitton, Roland Thissen, Cédric Wolters, Philippe Schmitt-Kopplin, Alexander Ruf, Junko Isa, Norbert Hertkorn, John M. Eiler, Toshihiro Yoshimura, Haruna Sugahara, Heather V. Graham, Yoshihiro Furukawa, Daisuke Araoka, Satoru Tanaka, Takaaki Yoshikawa, Fumie Kabashima, Kazunori Sasaki, Hajime Sato, Tomoya Yamazaki, Morihiko Onose, Mayu Morita, Yuki Kimura, Kuniyuki Kano, Junken Aoki, Kosuke Fujishima, Shin ichiro Nomura, Shogo Tachibana, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Hisayoshi Yurimoto, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Tatsuaki Okada, Sei ichiro Watanabe, Yuichi Tsuda, Kenji Hamase

    Journal of Chromatography Open   5   100134   2024.5   （ eISSN:2772-3917 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    The chirality of amino acids in extraterrestrial materials may provide an insight into the origin of the essential L-enantiopure amino acids in the terrestrial biosphere. In 2020, the Hayabusa2 mission succeeded in bringing back surface materials from the C-type asteroid (162173) Ryugu to the Earth. Amino acids were one of the targeted organic molecules to be studied in the Ryugu samples. To analyze the various structural isomers of amino acids, which were expected to be present, from the limited amount of the returned samples, the development of a highly-sensitive and selective analytical method was necessary. In the present study, a three-dimensional high-performance liquid chromatography (3D-HPLC) system has been developed for the enantioselective determination of five proteinogenic and three non-proteinogenic amino acids in the Ryugu samples, in which amino acids in the sample were separated by reversed-phase, anion-exchange and enantioselective columns after the fluorescence derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiozole. The applicability of the analytical system to the extraterrestrial samples was evaluated by analyzing several types of carbonaceous meteorites before applying the system to the Ryugu samples. In the analysis of the Ryugu samples, all of the target amino acids were successfully determined quantitatively. Non-proteinogenic amino acids including 2-amino-n-butyric acid, isovaline and norvaline, rarely present in the terrestrial environment, were found as almost racemic mixtures with 47.1 to 55.2%L.

    DOI： 10.1016/j.jcoa.2024.100134

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  • Development of a two-dimensional LC-MS/MS system for the determination of proline and 4-hydroxyproline enantiomers in biological and food samples. Reviewed International journal

    Chiharu Ishii, Yosuke Tojo, Komei Iwasaki, Akira Fujii, Takeyuki Akita, Masanobu Nagano, Masashi Mita, Tomomi Ide, Kenji Hamase

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   40 ( 5 )   881 - 889   2024.5   （ ISSN:0910-6340 eISSN:1348-2246 ）

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    A two-dimensional LC-MS/MS system has been developed for the enantioselective determination of proline (Pro), cis-4-hydroxyproline (cis-4-Hyp) and trans-4-hydroxyproline (trans-4-Hyp) in a variety of biological samples. The amino acids were pre-column derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and the NBD-derivatives were separated by a reversed-phase column (Singularity RP18) as their D plus L mixtures in the first dimension. The collected target fractions were then introduced into the second dimension where the enantiomers were separated by a Pirkle-type enantioselective column (Singularity CSP-001S) and determined by a tandem mass spectrometer (Triple Quad™ 5500). The method was validated by the standard amino acids and also by human plasma, and sufficient results were obtained for the calibration, precision and accuracy. The method was applied to human plasma and urine, bivalve tissues and fermented food/beverages. D-Pro was widely found in the human physiological fluids, bivalves and several fermented products. Although trans-4-D-Hyp was not found in all the tested samples, cis-4-D-Hyp was present in human urine and tissues of the ark shell, and further studies focusing on the origin and physiological significance of these D-enantiomers are expected.

    DOI： 10.1007/s44211-024-00530-w

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  • Evaluation of individual variation of D-amino acids in human plasma by a two-dimensional LC-MS/MS system and application to the early diagnosis of chronic kidney disease Reviewed International journal

    Chiharu ISHII, Takeyuki AKITA, Tomonori KIMURA, Shinsuke SAKAI, Masashi MITA, Tomomi IDE, Yoshitaka ISAKA, Kenji HAMASE

    Analytical Chemistry   96 ( 12 )   4876 - 4883   2024.3   （ ISSN:0003-2700 eISSN:1520-6882 ）

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    For the discovery of sensitive biomarkers of kidney function focusing on chiral amino acids, a multiple heart-cutting two-dimensional (2D) liquid chromatography-mass spectrometry (LC-MS)/MS system has been designed/developed. As the target analytes, alanine (Ala), aspartic acid, glutamic acid (Glu), leucine (Leu), lysine, methionine, phenylalanine (Phe), proline (Pro), serine (Ser), and valine were selected considering the presence of their d-forms in mammals. The 2D LC-MS/MS system consisted of the nonenantioselective reversed-phase separation of the target amino acids, the separations of the d- and l-enantiomers, and detection using MS/MS. Using the method, the plasma chiral amino acids, precolumn derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole, were isolated from other intrinsic substances, then determined without losing sensitivity by the fully automated whole-peak volume transfer operation from first to second dimension. In all of the tested plasma samples obtained from five healthy individuals and 15 patients with chronic kidney disease (CKD), the target chiral amino acids were determined without interference. In healthy individuals, the levels of all the tested d-amino acids were regulated in the low ranges. In contrast, the % d values of Glu, Leu, and Phe significantly increased with the progress of kidney dysfunction, besides the previously reported values of d-Ala, Pro, and Ser. Concerning Phe, the significant increase of the % d values (p < 0.05) was reported for the first time even in the mild CKD group compared to those of the healthy group; d-Phe might be a more sensitive marker than the previously reported d-forms. These results demonstrated the potential of these d-forms as the sensitive biomarkers of kidney function for the early diagnosis of CKD.

    DOI： 10.1021/acs.analchem.3c05309

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  • Development of a three-dimensional HPLC system for the determination of serine, threonine and allo-threonine enantiomers in the plasma of patients with chronic kidney disease Reviewed International journal

    Mai Oyaide, Chiharu Ishii, Takeyuki Akita, Tomonori Kimura, Shinsuke Sakai, Masayuki Mizui, Masashi Mita, Tomomi Ide, Yoshitaka Isaka, Kenji Hamase

    Journal of Chromatography A   1719   464739 - 464739   2024.3   （ ISSN:0021-9673 eISSN:1873-3778 ）

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    A highly-selective three-dimensional high-performance liquid chromatographic (3D-HPLC) system was developed for the determination of serine (Ser), threonine (Thr) and allo-threonine (aThr) enantiomers in human plasma to screen the new biomarker of chronic kidney disease (CKD). d-Ser has been reported to be the candidate biomarker of CKD, however, multiple biomarkers are still required. Therefore, Ser analogs of hydroxy amino acids are the focus in the present study. For the sensitive analysis, the amino acids were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole and detected by their fluorescence. The 3D-HPLC system consisted of a reversed-phase column (Singularity RP18, 1.0 × 250 mm), an anion-exchange column (Singularity AX, 1.0 × 150 mm) and a Pirkle-type chiral stationary phase (Singularity CSP-013S, 1.5 × 250 mm). The developed method was validated and applied to the human plasma samples obtained from 15 healthy volunteers and 165 CKD patients. The concentrations of the d-forms were 1.13-2.26 (Ser), 0.01-0.03 (Thr) and 0.04-0.10 μM (aThr) for the healthy volunteers and 0.95-19.0 (Ser), 0-0.57 (Thr) and 0.04-1.02 μM (aThr) for the CKD patients. The concentrations and the %d values of all the target d-amino acids were increased along with the decreasing of renal function and further investigation for clinical applications are expected.

    DOI： 10.1016/j.chroma.2024.464739

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    Repository Public URL： https://hdl.handle.net/2324/7178699

  • Enantioselective analysis of lactate, hydroxybutyrates and malate in human physiological fluids using a three-dimensional HPLC system Reviewed International coauthorship International journal

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    Chromatography   44 ( 3 )   105 - 113   2023.9   （ ISSN:13428284 eISSN:13483315 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society for Chromatographic Sciences  

    <p>For the highly-selective analysis of lactic acid (LA), 2-hydroxybutyric acid (2HB), 3-hydroxybutyric acid (3HB) and malic acid (MA) enantiomers in human physiological fluids, a three-dimensional (3D) HPLC method following the fluorescence derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole has been designed and developed. The 3D-HPLC system was composed of reversed-phase, mixed-mode and enantioselective columns, and the conditions of all the dimensions were thoroughly investigated. In the first and second dimensions, the target hydroxy acids were separated from most of the interfering substances in the clinical samples. In the third dimension, the enantiomers were separated with resolution values higher than 3.47. The present method was validated by checking the calibration curves, precision and accuracy using standard solutions and human samples, and satisfactory results were acquired. Using the 3D-HPLC system, D-LA, L-LA, D-3HB, L-3HB and L-2HB were determined in the human plasma and urine (MA enantiomers were not determined). The concentrations of the detected enantiomers in the human plasma were 6.2, 660, 34.0, 1.0 and 19.0 µM, and those in the human urine were 13.4, 88.3, 4.5, 3.7 and 4.5 µM, respectively. </p>

    DOI： 10.15583/jpchrom.2023.015

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  • Development of an enantioselective three-dimensional HPLC system for the determination of alanine, valine, isoleucine, allo-isoleucine and leucine in human plasma and urine Reviewed International journal

    Yuri NAGATA, Takeyuki AKITA, Chiharu ISHII, Mai OYAIDE, Masashi MITA, Tomomi IDE, Kenji HAMASE

    Journal of Pharmaceutical and Biomedical Analysis Open   2   100013 - 100013   2023.9   （ ISSN:2949-771X ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jpbao.2023.100013

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  • Design of Novel Mixed-Mode Columns for Analysis of Amino Acids Derivatized with 4-Fluoro-7-nitro-2,1,3-benzoxadiazole and the Evaluation of Retention Properties Reviewed International journal

    NAGATA Yuri, AKITA Takeyuki, FURUSHO Aogu, ISHII Chiharu, MITA Masashi, HAMASE Kenji

    CHROMATOGRAPHY   44 ( 2 )   83 - 87   2023.6   （ ISSN:13428284 eISSN:13483315 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society for Chromatographic Sciences  

    <p>Three-dimensional (3D) HPLC methods are useful tools for the selective analysis of biomolecules in complicated real-world matrices, however, the columns applicable for the second dimension are still limited. In the present study, two types of mixed-mode columns (Singularity MX-102 and 103) were newly designed/developed focusing on the separation of <i>N</i>-protected chiral amino acids. The retention profiles of the two mixed-mode columns were evaluated using 10 proteinogenic amino acids with various chemical properties, namely, alanine, asparagine (Asn), glutamine, glycine, lysine (Lys), phenylalanine, proline, serine (Ser), threonine and valine (Val), and compared to that of a mixed-mode column (Singularity MX-001) previously adopted for the 3D-HPLC analysis of chiral amino acids. The amino acids were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) and detected by their fluorescence (ex. 470 nm, em. 530 nm). For the mobile phases, mixed solutions of acetonitrile/methanol containing formic acid were used. As a result, NBD-Val eluted the fastest for all the tested mixed-mode columns. However, the NBD-amino acids most strongly retained on the columns were different (Asn for MX-001, Ser for MX-102 and Lys for MX-103). Also, the elution orders of the 10 NBD-amino acids on the three mixed-mode columns were not the same as that on the reversed-phase C18 column, and characteristic elution orders and retention properties were observed for the individual mixed-mode columns. These results indicated that mixed-mode columns reported in the present study have different retention mechanisms, and the development of highly selective 3D-HPLC systems using these columns is expected. </p>

    DOI： 10.15583/jpchrom.2023.006

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  • Development of a three-dimensional HPLC system for acidic amino acid enantiomers and determination of their amounts in mice lacking D-aspartic acid oxidase activity Reviewed International journal

    Chiharu Ishii, Rin Morinaga, Miho Takahashi, Masashi Mita, Takeyuki Akita, Kenji Hamase

    Journal of Pharmaceutical and Biomedical Analysis Open   1   100004 - 100004   2023.6   （ ISSN:2949-771X ）

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    DOI： 10.1016/j.jpbao.2023.100004

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  • Chiral Amino Acid Analysis in the Plasma of B6DAO<sup>-/-</sup> Mice Lacking D-Amino Acid Oxidase Activity Reviewed International journal

    ISHII Chiharu, AKITA Takeyuki, MITA Masashi, KONNO Ryuichi, HAMASE Kenji

    CHROMATOGRAPHY   44 ( 1 )   39 - 43   2023.2   （ ISSN:13428284 eISSN:13483315 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society for Chromatographic Sciences  

    <p>A B6DAO<sup>-/-</sup> mouse strain lacking D-amino acid oxidase (DAO) activity with the genetic background of C57BL strain, frequently used to produce disease model mice in the current medical/life science areas, was newly developed. In the plasma of the control C57BL/6J and mutant B6DAO<sup>-/-</sup> mice, five D-amino acids widely found in mammals were determined using a highly-selective two-dimensional LC-MS/MS system. As the targets, D-alanine (Ala), D-aspartic acid (Asp), D-leucine (Leu), D-proline (Pro) and D-serine (Ser) were selected. All five chiral amino acids were clearly observed, and the D-enantiomers of the neutral amino acids (Ala, Leu, Pro and Ser) significantly increased in the mutant B6DAO<sup>-/-</sup> mice (3.69-36.91 nmol/mL) compared to those in the control C57BL/6J mice (0.24-2.03 nmol/mL), whereas the amounts of D-Asp were almost equal between the two strains. The obtained values are consistent with those in previous reports using ddY/DAO<sup>-/-</sup> mice having spontaneous DAO deficiency and the control ddY/DAO<sup>+/+</sup> mice. These results indicated that the newly-developed B6DAO<sup>-/-</sup> strain is practically useful to clarify the controlling mechanism of intrinsic D-amino acids that are expected as new bio-functional molecules and/or biomarkers in mammals. </p>

    DOI： 10.15583/jpchrom.2023.002

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  • Two-dimensional chiral HPLC analysis of lactate, hydroxybutyrates and malate in human plasma Reviewed International coauthorship International journal

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE Kenji HAMASE

    Chromatography   43 ( 3 )   119 - 126   2022.10   （ ISSN:13428284 eISSN:13483315 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society for Chromatographic Sciences  

    <p>For the simultaneous determination of lactate (LA), 2-hydroxybutyrate (2HB), 3-hydroxybutyrate (3HB) and malate (MA) enantiomers, a new separation technique in a two-dimensional high-performance liquid chromatography (2D-HPLC) system following the fluorescence derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole has been developed. The 2D-HPLC system was composed of the reversed-phase (1D) and enantioselective (2D) separations. In the first dimension, the target hydroxy acids were separated as their D plus L mixtures on a Singularity RP18 column (1.0 mm i.d. x 250 mm), and the enantiomers were separated in the second dimension using a polysaccharide-based chiral stationary phase, Chiralpak IG (2.0 mm i.d. x 250 mm). By using the Chiralpak IG column, the LA, 2HB, 3HB and MA enantiomers were separated with resolution values of 3.47, 3.63, 6.81 and 3.72, respectively. The developed 2D-HPLC system was applied to human plasma, and trace levels of D-LA and L-3HB in addition to their major antipodes were determined. The acquired %D of LA (the percentage of D-LA over total LA) and %L of 3HB (the percentage of L-3HB over total 3HB) were 1.0 and 2.7, respectively. For 2HB, only the L-form was detected, while the MA enantiomers were not found in the human plasma.</p>

    DOI： 10.15583/jpchrom.2022.011

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  • Off-line two-dimensional LC-MS/MS determination of tryptophan enantiomers in mammalian urine and alteration of their amounts in d-amino acid oxidase deficient mice. Reviewed International journal

    Chiharu Ishii, Noburo Takizawa, Takeyuki Akita, Masashi Mita, Tomomi Ide, Ryuichi Konno, Kenji Hamase

    Journal of pharmaceutical and biomedical analysis   219   114919 - 114919   2022.9   （ ISSN:0731-7085 eISSN:1873-264X ）

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    D-Tryptophan (D-Trp) is one of the minor D-enantiomers of amino acids discovered in microbes and mollusca. In the present study, a highly-selective 2D chiral LC-MS/MS method has been designed and developed focusing on the determination of Trp enantiomers to investigate the presence and regulation of free D-Trp in mammals. The developed system consisted of a reversed-phase separation for the first dimension, an enantioselective separation for the second dimension and also the detection using a triple quadrupole mass spectrometer for the third/fourth dimensions. Using the present method, urinary D-Trp in mammals, including healthy human volunteers and mice, were successfully determined. Although only l-Trp was observed in a mixed urine sample of healthy volunteers, small amounts of D-Trp were detected in the C57BL/6J mice (n = 5, %D=6.18 ± 0.47). In B6DAO- mice lacking the activity of d-amino acid oxidase (DAO), relatively high levels of D-Trp were observed (n = 6, %d=27.43 ± 3.26). The obtained %d values of Trp in the urine of the C57BL/6J mice and B6DAO- mice were confirmed using various enantioselective columns having different separation properties. These results indicate that the urinary D-Trp level is regulated by DAO in mammals, and further investigations, such as tissue distribution and physiological significance of the intrinsic D-Trp, are expected.

    DOI： 10.1016/j.jpba.2022.114919

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  • Development of an off-line heart cutting two-dimensional HPLC system for enantioselective analysis of serine, threonine and allo-threonine in human physiological fluids Reviewed International journal

    Mai Oyaide, Aogu Furusho, Chiharu Ishii, Takeyuki Akita, Masashi Mita, Tomomi Ide, Kenji Hamase

    Journal of Pharmaceutical and Biomedical Analysis   217   114807 - 114807   2022.8   （ ISSN:0731-7085 eISSN:1873-264X ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER  

    A highly-selective two-dimensional high-performance liquid chromatographic (2D-HPLC, off-line heart cutting mode) system was developed for the determination of serine (Ser), threonine (Thr) and allo-threonine (aThr) enantiomers in human physiological fluids. Ser, Thr and aThr have a hydroxy group in their side chains, and the development of a simultaneous analytical method with a practically sufficient enantio/chemo-selectivity has been required to clarify their amounts in human physiological fluids. The amino acids in the samples were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole and were isolated by a reversed-phase column (Singularity RP18, 1.0 x 250 mm) in the first dimension. After the target amino acids were collected, the fractions were manually introduced into an enantioselective column in the second dimension and were detected by their fluorescence. For the second dimension, a Pirkle-type chiral stationary phase (Singularity CSP-013S, 1.5 x 250 mm) was used. The resolution values of the enantiomers obtained by the Singularity CSP-013S column were 7.64 for Ser, 7.58 for Thr and 4.71 for aThr by using the mixture of methanol and acetonitrile containing formic acid as the mobile phases. The developed method was validated and applied to human plasma and urine. In the plasma, the obtained %D values (the percentage of D-form to total amino acid) were 1.7 for Ser, and trace levels of D-aThr and D-Thr were observed. In the urine, the %D values were 48.0 for Ser, 1.6 for Thr and 8.0 for aThr (calculated using D-aThr and L-Thr).

    DOI： 10.1016/j.jpba.2022.114807

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    Repository Public URL： https://hdl.handle.net/2324/7174359

  • Enantioselective determination of hydroxy amino acids in Japanese traditional amber rice vinegars Reviewed International journal

    Mai OYAIDE, Chiharu ISHII, Akira FUJII, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Kenji HAMASE

    Chromatography   43 ( 2 )   59 - 65   2022.5   （ ISSN:13428284 eISSN:13483315 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society for Chromatographic Sciences  

    <p>A fully-automated two-dimensional (2D) HPLC system for the determination of serine (Ser), threonine (Thr) and <i>allo</i>-threonine (aThr) enantiomers was developed. The system was validated and applied to the determination of the target hydroxy amino acid enantiomers in vinegar samples including the Japanese traditional amber rice vinegar. The Japanese traditional amber rice vinegar is one of the typical natural fermented products containing high levels of D-amino acids, and the clarification of the amounts of hydroxy amino acid enantiomers is expected. For the on-line 2D-HPLC system, a narrowbore ODS column (Singularity RP18, 1.0 x 250 mm) was used in the first dimension, and an originally-designed Pirkle-type chiral stationary phase (Singularity CSP-013S, 1.5 x 250 mm) was utilized in the second dimension. The target hydroxy amino acids were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) and detected by their fluorescence (ex. 470 nm, em. 530 nm). The concentrations and the %D values were compared among a grain vinegar, a widely-distributed black vinegar and Japanese traditional amber rice vinegars (fermented/aged 1 or 5 years by microorganisms in an earthenware jar). The amounts of hydroxy amino acid enantiomers were low (0.21-0.38 μmol/mL, only L-forms) in the grain vinegar, and relatively high amounts of the L-forms were observed (1.05-1.61 μmol/mL) in the widely-distributed black vinegar. On the other hand, clear peaks of the D-forms (0.16-0.86 μmol/mL for D-Ser, 0.02-0.11 μmol/mL for D-aThr) as well as high amounts of the L-forms (2.27-2.51 μmol/mL for L-Ser, 1.85-2.10 μmol/mL for L-Thr) were observed in the Japanese traditional amber rice vinegars. The amounts of D-Ser and D-aThr clearly increased with increasing the fermentation/aging period. This is the first report showing the profiles of the hydroxy amino acid enantiomers simultaneously, and further investigations using various fermented food/beverage samples are expected. </p>

    DOI： 10.15583/jpchrom.2022.006

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  • Two-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids in Food Samples and Human Physiological Fluids Using Fluorescence Derivatization with 4-(<i>N</i>,<i>N</i>-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole Reviewed International coauthorship International journal

    FURUSHO Aogu, IKEJIRI Karina Akemy, ISHII Chiharu, AKITA Takeyuki, MITA Masashi, NAGANO Masanobu, IDE Tomomi, HAMASE Kenji

    CHROMATOGRAPHY   43 ( 1 )   29 - 35   2022.2   （ ISSN:13428284 eISSN:13483315 ）

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    <p>A two-dimensional high-performance liquid chromatographic (2D-HPLC) system using the pre-column derivatization with 4-(<i>N</i>,<i>N</i>-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-F) has been developed for the determination of alanine (Ala), aspartic acid (Asp) and serine (Ser) enantiomers. For the precise determination of trace amounts of D-amino acids in complex matrices, a highly sensitive and selective method is required. In the present study, amino acids were derivatized with DBD-F for the sensitive fluorescence detection and were analyzed by a selective 2D-HPLC system combining a reversed-phase column (Singularity RP18, 1.0 x 500 mm) and an enantioselective column (Singularity CSP-001S, 1.5 x 250 mm). The established system was successfully applied to the chiral amino acid analyses of Japanese traditional amber rice vinegar, human plasma and human urine samples. In the Japanese traditional amber rice vinegar and human urine, relatively high amounts of all the target D-amino acids were observed (%D=5.8-37.7), while trace amounts of D-Ser and D-Ala were found in human plasma (%D=0.5-2.1). </p>

    DOI： 10.15583/jpchrom.2021.020

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  • Acridinium Ester Chemiluminescence: Methyl Substitution on the Acridine Moiety Invited Reviewed International journal

    Manabu Nakazono, Shinkoh Nanbu, Takeyuki Akita, Kenji Hamase

    Journal of Oleo Science   70 ( 11 )   1677 - 1684   2021.11

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    DOI： https://doi.org/10.5650/jos.ess21186

  • Chiral analysis of lactate in various food samples including Japanese traditional amber rice vinegar and the developmental change during fermentation processes Reviewed International journal

    Chin-Ling Hsieh, Chiharu Ishii, Takeyuki Akita, Akira Fujii, Kazunori Hashiguchi, Masanobu Nagano, Masashi Mita, Jen-Ai Lee, Kenji Hamase

    Chromatography   42 ( 3 )   151 - 158   2021.10

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    DOI： 10.15583/jpchrom.2021.017

  • Development of a selective three-dimensional HPLC system for enantiomer discriminated analysis of lactate and 3-hydroxybutyrate in human plasma and urine Reviewed International journal

    Chin-Ling Hsieh, Takeyuki Akita, Masashi Mita, Tomomi Ide, Jen-Ai Lee, Kenji Hamase

    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS   195   113871 - 113871   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jpba.2020.113871

  • Determination of phenylalanine enantiomers in the plasma and urine of mammals and D-amino acid oxidase deficient rodents using two-dimensional high-performance liquid chromatography Reviewed International journal

    Sui-Wen Hsiao, Chiharu Ishii, Aogu Furusho, Chin-Ling Hsieh, Yukiko Shimizu, Takeyuki Akita, Masashi Mita, Tadashi Okamura, Ryuichi Konno, Tomomi Ide, Ching-Kuo Lee, Kenji Hamase

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   1869 ( 1 )   140540 - 140540   2021.1

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    DOI： 10.1016/j.bbapap.2020.140540

  • Chemiluminescence of methoxycarbonylphenyl 10-methyl-10λ4 -2,7-disubstituted acridine-9-carboxylate derivatives Reviewed International journal

    403   2020.12

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    Methoxycarbonylphenyl 10-methyl-10λ4-2,7-disubstituted acridine-9-carboxylate derivatives were synthesized, and both their chemiluminescence intensities at pH 7−10 and their chemical stabilities were clarified. The products and generation efficiency of the chemiluminescence reactions were evaluated. 4-(Methoxycarbonyl)phenyl 10-methyl-10λ4-2,7-dimethylacridine-9-carboxylate gave relatively strong chemiluminescence intensities at pH 7−10 and was applied to the measurement of hydrogen peroxide.

    DOI： 10.1016/j.jphotochem.2020.112851

  • High-performance liquid chromatographic determination of chiral amino acids using pre-column derivatization with o-phthalaldehyde and N-tert-butyloxycarbonyl-D-cysteine and application to vinegar samples Reviewed International journal

    Aogu FURUSHO, Mintranee OBROMSUK, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Pornchai ROJSITTHISAK, Kenji HAMASE

    Chromatography   147 - 151   2020.10

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    DOI： 10.15583/jpchrom.2020.015

  • Three-dimensional high-performance liquid chromatographic analysis of chiral amino acids in carbonaceous chondrites Reviewed International journal

    Aogu Furusho, Takeyuki Akita, Masashi Mita, Hiroshi Naraoka, Kenji Hamase

    JOURNAL OF CHROMATOGRAPHY A   1625   461255 - 461255   2020.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.chroma.2020.461255

  • Synthesis, chemiluminescence, and application of 2,4-disubstituted phenyl 10-methyl-10 lambda(4)-acridine-9-carboxylates Reviewed

    Manabu Nakazono, Shinkoh Nanbu, Takeyuki Akita, Kenji Hamase

    DYES AND PIGMENTS   170   2019.11

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    DOI： 10.1016/j.dyepig.2019.107628

  • Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease Reviewed International journal

    Aogu Furusho, Reiko Koga, Takeyuki Akita, Masashi Mita, Tomonori Kimura, Kenji Hamase

    ANALYTICAL CHEMISTRY   91 ( 18 )   11569 - 11575   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.analchem.9b01615

  • Determination of chiral amino acids in various fermented products using a two-dimensional HPLC-MS/MS system Reviewed International journal

    Chiharu ISHII, Takeyuki AKITA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE

    Chromatography   40   83 - 87   2019.5

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    DOI： 10.15583/jpchrom.2019.011

  • Development of a three-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in mammalian urine Reviewed International journal

    Chin-Ling HSIEH, Po-Yeh LIN, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    Chromatography   25 - 32   2019.1

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    DOI： 10.15583/jpchrom.2018.021

  • Determination of Trace Amounts of Chiral Amino Acids in Complicated Biological Samples Using Two-Dimensional High-Performance Liquid Chromatography with an Innovative "Shape-Fitting" Peak Identification/Quantification Method Reviewed International journal

    Kenji HAMASE, Tatsuhiko IKEDA, Chiharu ISHII, Shoto ISHIGO, Kei MASUYAMA, Takeyuki AKITA, Aogu FURUSHO, Miho TAKAHASHI, Tomomi IDE, Masashi MITA

    Chromatography   2018.10

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    DOI： 10.15583/jpchrom.2018.019

  • Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid Reviewed International journal

    Chiharu Ishii, Takeyuki Akita, Masashi Mita, Tomomi Ide, Kenji Hamase

    JOURNAL OF CHROMATOGRAPHY A   1570   91 - 98   2018.10

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    DOI： 10.1016/j.chroma.2018.07.076

  • Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain Reviewed International journal

    Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Kenji HAMASE

    Chromatography   39   83 - 90   2018.4

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    DOI： 10.15583/jpchrom.2018.007

  • Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar Reviewed International journal

    Nutchaya SEREEKITTIKUL, Reiko KOGA, Takeyuki AKITA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Akira FUJII, Kazunori HASHIGUCHI, Masanobu NAGANO, Wolfgang LINDNER, Kenji HAMASE

    Chromatography   39   59 - 66   2018.3

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    DOI： 10.15583/jpchrom.2018.002

  • Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrow-bore online two-dimensional high-performance liquid chromatography system Reviewed International journal

    Chin-Ling Hsieh, Reiko Koga, Aogu Furusho, Takeyuki Akita, Masashi Mita, Tomomi Ide, Jen-Ai Lee, Kenji Hamase

    JOURNAL OF SEPARATION SCIENCE   41 ( 6 )   1298 - 1306   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jssc.201701283

  • EFFECT OF ARYL SUBSTITUENTS ON INTRAMOLECULAR CYCLIZATION OF 2,2 '-BIPHENOQUINONES Reviewed

    Naoto Hayashi, Akifumi Kanda, Taku Kamoto, Hiroyuki Higuchi, Takeyuki Akita

    HETEROCYCLES   79   865 - 872   2009.4

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    DOI： 10.3987/COM-08-S(D)57

  • Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones Reviewed

    Junzo Hirano, Kenji Hamase, Takeyuki Akita, Kiyoshi Zaitsu

    LUMINESCENCE   23 ( 5 )   350 - 355   2008.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/bio.1044

  • Magnetic properties of dendritic polycarbenes substituted by bulky peripheral groups Reviewed International journal

    Takeyuki Akita, Noboru Koga

    Polyhedron   24 ( 16-17 )   2321 - 2325   2005.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.poly.2005.03.067

  • Crystal structure of 6-methoxy-4-quinolone, C10H9NO2·2H2O Reviewed International journal

    21 ( 3 )   x45   2005.1

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    The title compound, 6-methoxy-4-quinolone (3), was synthesized by the oxidation of 5-methoxyindole-3-acetic acid (2), and its crystal structure was determined by X-ray diffraction analysis. The compound crystallized in the monoclinic system, space group P21/n, with cell parameters of a = 4.547(2)Å, b = 16.328(8)Å, c = 13.731(4)Å, β = 92.38(2)°, and Z = 4. The final residual factor was 0.064. 2005

    DOI： 10.2116/analscix.21.x45

  • Crystal structure of N-[(6-methoxy-4-oxo-1,4-dihydroquinolin-3-yl) methyl]-2,2-dimethylpropanamide Reviewed International journal

    Junzo Hirano, Kenji Hamase, Takeyuki Akita, Kiyoshi Zaitsu

    Analytical Sciences: X-ray Structure Analysis Online   20 ( 3 )   x115 - x116   2004.1

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    DOI： 10.2116/analscix.20.x115

  • Theoretical study on the exchange interaction between metal ion and organic radical through pyridine, bipyridine and terpyridine ligands Reviewed International journal

    Jingping Zhang, Madoka Suehiro, Akira Sakane, Satoru Karasawa, Takeyuki Akita, Noboru Koga

    Molecular Crystals and Liquid Crystals   376   431 - 436   2002.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/10587250210747

  • Magnetic properties after irradiation of poly(m-phenyleneethynylene) having diazo and nitronylnitroxide groups and its model compounds Reviewed

    T Akita, N Koga

    POLYHEDRON   20 ( 11-14 )   1475 - 1477   2001.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/S0277-5387(01)00638-6

  • Erratum Experimental and theoretical spin density in a ferromagnetic molecular complex presenting interheteromolecular hydrogen bonds (Journal of American Chemical Society (1999) 121 (10126-10133)) Reviewed International coauthorship

    Y. Pontillon, Takeyuki Akita, A. Grand, K. Kobayashi, E. Lelievre-Berna, J. Pecaut, E. Ressouche, J. Schweizer

    Journal of the American Chemical Society   121 ( 47 )   1999.12

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  • Experimental and theoretical spin density in a ferromagnetic molecular complex presenting interheteromolecular hydrogen bonds Reviewed International journal

    Journal of the American Chemical Society   121 ( 43 )   10126 - 10133   1999.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/ja991042u

  • Experimental and Theoretical Spin Density in a Ferromagnetic Molecular Complex Reviewed

    Molecular Crystals and Liquid Crystals   334   211 - 220   1999.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/10587259908023319

  • Photochemical formation of ferrimagnetic chains from a pair of polymeric complexes made of octahedral bis(hexafluoroacetylacetonato)manganese(II) with diazodi(4-pyridyl)methane in the cis and trans configurations as repeating units Reviewed International journal

    Satoru Karasawa, Yoko Sano, Takeyuki Akita, Noboru Koga, Tetsuji Itoh, Hiizu Iwamura, Pierre Rabu, Marc Drillon

    Journal of the American Chemical Society   120 ( 39 )   10080 - 10087   1998.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/ja981293n

  • Intermolecular spin-coupler Ferromagnetic spin interactions through hydrogen bond in the complexes of arylboronic acids with aryl nitronyl nitroxides Reviewed International journal

    Takeyuki Akita, Keiji Kobayashi

    Molecular Crystals and Liquid Crystals   306   257 - 264   1997.1

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    DOI： 10.1080/10587259708044574

  • Molecular structure and magnetic properties of N,N-bis {4-methoxy-3,5-bis(N-tert-butyl-N-oxyamino)phenyl} aminoxyl. An approach to a stable and high-spin pentaradical Reviewed

    Junpei Fujita, Yoshihisa Matsuoka, Kenji Matsuo, Masakazu Tanaka, Takeyuki Akita, Noboru Koga, Hizu Iwamura

    Chemical Communications   ( 24 )   2393 - 2394   1997.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/a704160h

  • Magnetic properties of nitronyl nitroxide radicals substituted in phenylboronic acid The BOH⋯O hydrogen bond as a constituent unit of a one-dimensional suprastructure exhibiting a ferromagnetic spin interaction Reviewed International journal

    9 ( 4 )   346 - 349   1997.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/adma.19970090414

  • Ferromagnetic spin interaction through the interheteromolecular hydrogen bond A 1:1 crystalline complex of phenylboronic acid and phenyl nttronyl nitroxide Reviewed International journal

    Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi

    Molecular Crystals and Liquid Crystals   278-279   39 - 45   1996.12

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  • Intramolecular spin-interactions between two nitronyl nitroxide or imino nitroxide radical units linked to thieno[2,3-b]thiophene and thieno[2,3-b]thieno[3',2'-d]thiophene chromophores Reviewed International journal

    Takeyuki Akita, Keiji Kobayashi

    Tetrahedron   52 ( 20 )   6893 - 6902   1996.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/0040-4020(96)00324-9

  • Ferromagnetic spin interaction in a crystalline molecular complex formed by inter-heteromolecular hydrogen bonding A 1:1 complex of phenyl nitronyl nitroxide radical and phenylboronic acid Reviewed International journal

    Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi

    Journal of the Chemical Society, Chemical Communications   ( 18 )   1861 - 1862   1995.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/C39950001861

  • Intramolecular spin interactions between two radical units through isomeric chromophores, thieno[3,2-b]thiophene and thieno[2,3-b]thiophene Reviewed

    Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi, Kiminori Ushida

    Tetrahedron Letters   36 ( 31 )   5543 - 5546   1995.7

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    DOI： 10.1016/00404-0399(50)1047L-

  • Crystal structures and magnetic properties of nitronyl nitroxide and imino nitroxide radicals attached to thieno[3,2-b]- and thieno[2,3-b]thiophene rings Reviewed

    Takeyuki Akita, Yasuhiro Mazaki, Keiji Kobayashi, Noboru Koga, Hiizu Iwamura

    Journal of Organic Chemistry   60 ( 7 )   2092 - 2098   1995.4

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  • 【分】メートル長高分離能光学分割カラムを用いる食酢中アラニン及びセリン鏡像異性体の分析

    石井 千晴, 古賀 夢美, 藤井 暁, 秋田 健行, 三田 真史, 長野 正信, 浜瀬 健司

    分析化学   73 ( 7-8 )   337 - 344   2024.7   （ ISSN:0525-1931 ）

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    Language：Japanese   Publisher：(公社)日本分析化学会  

    近年,L-アミノ酸の鏡像異性体であるD-アミノ酸の存在が微量ながら哺乳類体内で明らかにされ,特にD-セリン(D-Ser)やD-アラニン(D-Ala)などは新規機能性分子として注目を集めている.経口摂取したD-アミノ酸が哺乳類組織に移行することから,D体を天然に含有する食品や飲料は機能性食材候補として注目され,アミノ酸の正確なキラル識別含量解析が期待されている.しかし,微量なD-アミノ酸を正確に定量するためには十分な鏡像異性体分離に加えて分析法の選択性向上が課題であり,光学分割カラムの伸長による分離場の増加は双方の改善に効果的であると考えられる.そこで本研究では,メートル長光学分割カラムを装備したキラルHPLCシステムの開発を行い,カラム伸長に伴う分離能変化を評価するとともに,代表的な発酵食品である食酢試料中のAla及びSer鏡像異性体の含量解析を行った.その結果,カラム伸長に伴い対象アミノ酸の鏡像異性体分離度(Rs)及び実効理論段数(Neff)が向上し,全長1000mmのカラムでは250mmのカラムを用いた結果と比較してRsが1.5-1.6倍,Neffが2.2-2.3倍であった.また,メートル長カラムを装備したキラルHPLCにより,食酢試料中のAla及びSer鏡像異性体について夾雑成分による妨害を低減した含量解析が可能であった.本分析法を用いて,穀物酢,純米酢及びさまざまな黒酢におけるAla,Ser鏡像異性体の含量解析を行った結果,伝統的製法で醸造された黒酢にはD体が多量に含まれていることが示された.特に鹿児島県内で製造された黒酢中のD-Ala及びD-Ser含量はそれぞれ1.79-5.58μmol mL-1及び0.12-0.89μmol mL-1であり,高濃度の存在が認められた.加えて,発酵熟成期間の延長に伴いD-Ser含量が有意に増加することも明らかにし,長期発酵熟成黒酢の機能性食材としての有用性が示された.(著者抄録)

  • Analysis of Alanine and Serine Enantiomers in Vinegars Using a Meter-long High-resolution Enantioselective Column Reviewed

    Ishii, C; Koga, Y; Fujii, A; Akita, T; Mita, M; Nagano, M; Hamase, K

    BUNSEKI KAGAKU   73 ( 7 )   337 - 344   2024   （ ISSN:0525-1931 ）

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  • グリシンおよび酸性アミノ酸を含有するジペプチドを対象とした二次元キラルHPLC分析法の開発

    江頭 花奈、秋田 健行、中川 雄太、石井 千晴、三田 真史、植田 正、浜瀬 健司

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：横浜   Country：Japan  

  • ヒト体液中親水性D-アミノ酸の二次元HPLC分析と発酵食品摂取による影響

    近藤 菜穂、尾中 孝彰、小田 京香、長谷川 美優、石井 千晴、秋田 健行、三田 真史、井手 友美、浜瀬 健司

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：横浜   Country：Japan  

  • 各種哺乳動物における尿中疎水性アミノ酸のキラル識別分析

    尾中 孝彰、近藤 菜穂、小田 京香、長谷川 美優、石井 千晴、清水 有紀子、岡村 匡史、山﨑 真大、秋田 健行、三田 真史、井手 友美、浜瀬 健司

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：横浜   Country：Japan  

  • 老化・劣化タンパク質中の異性化アミノ酸解析を可能とする二次元キラルLC-MS/MS法開発 Invited

    石井 千晴、秋田 健行、三田 真史、村上 祐介、植田 正、浜瀬 健司

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • グリシン含有ジペプチドを対象とする二次元キラルHPLC法開発

    横谷昌祐，秋田健行，石井千晴，三田真史，浜瀬健司

    第34回クロマトグラフィー科学会議  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • アラニン、アスパラギン酸、セリン、乳酸および3-ヒドロキシ酪酸を対象とする二次元キラルHPLC法開発とヒト生体液試料の分析

    坂元瞭太，蔡　欣妙，石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    第34回クロマトグラフィー科学会議  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 光リアクター搭載多次元HPLCによるNBD-Trpの光学識別蛍光分析法開発

    山下愛絵，石井千晴，秋田健行，根岸栄一，井本啓史，三田真史，浜瀬健司

    第34回クロマトグラフィー科学会議  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 二次元HPLCを用いる植物・食品中におけるAla、Asp、GluおよびSerのキラル識別含量解析

    小田京香，長谷川美優，石井千晴，三田真史，秋田健行，浜瀬健司

    日本分析化学会第72年会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • 加齢性疾患におけるキラルアミノ酸の含量変化と多次元LCによるスクリーニング法開発 Invited

    石井千晴，秋田健行，三田真史，井手友美，村上祐介，木村友則，浜瀬健司

    日本分析化学会第72年会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • ヒト血中におけるSer/Thr/aThrの三次元キラルHPLC分析法開発と腎不全の新規バイオマーカー探索

    小柳出麻衣，石井千晴，三田真史，秋田健行，井手友美，木村友則，浜瀬健司

    日本分析化学会第72年会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • 哺乳類体内におけるヒスチジンおよびアルギニン鏡像異性体の三次元HPLC分析

    長谷川美優，石井千晴，秋田健行，三田真史，浜瀬健司

    日本分析化学会第72年会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • 三次元HPLCを用いる脂肪族キラルアミノ酸一斉分析法開発と慢性腎臓病患者における血漿中含量の解析

    永田優凜，秋田健行，石井千晴，小柳出麻衣，三田真史，井手友美，木村友則，浜瀬健司

    第17回D-アミノ酸学会学術講演会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長岡   Country：Japan  

  • 微粒子充填型高分離能光学分割カラムを用いるAsn/Asp/Gln/Glu鏡像異性体の二次元HPLC分析法開発

    岡部理子，秋田健行，石井千晴，中川雄太，三田真史，浜瀬健司

    第17回D-アミノ酸学会学術講演会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長岡   Country：Japan  

  • 二次元LC-MS/MSを用いるヒト血中D-アミノ酸の含量解析と新規腎機能マーカーの探索

    石井千晴，秋田健行，三田真史，井手友美，木村友則，浜瀬健司

    第35回バイオメディカル分析科学シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese  

    Venue：札幌   Country：Japan  

  • 直鎖脂肪族アミノ酸を有する新規高性能Pirkle型固定相の開発とキラルアミノ酸の網羅的二次元HPLC分析

    中川雄太，秋田健行，石井千晴，三田真史，浜瀬健司

    第35回バイオメディカル分析科学シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • ロイシン/イソロイシン/アロイソロイシン鏡像異性体を対象とする二次元HPLC分析法の開発とラット血漿および尿中含量の解析

    山部真弓，石井千晴，清水有紀子，秋田健行，三田真史，岡村匡史，浜瀬健司

    第35回バイオメディカル分析科学シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • ヒスチジンおよびアルギニン鏡像異性体を対象とする三次元HPLC分析法の開発

    長谷川美優，石井千晴，秋田健行，藤井　暁，三田真史，長野正信，浜瀬健司

    第35回バイオメディカル分析科学シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • 生体・食品・宇宙試料におけるキラルアミノ酸ならびに類緑化合物の三次元・四次元HPLC分析

    浜瀬健司，石井千晴，秋田健行，三田真史，井手友美，木村友則，奈良岡　浩

    第35回バイオメディカル分析科学シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Poster presentation  

    Venue：札幌   Country：Japan  

  • Selective determination of D-amino acids in human plasma using a two-dimensional LC-MS/MS system toward early-diagnosis of chronic kidney disease International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tomonori KIMURA, Kenji HAMASE

    33rd International Symposium on Pharmaceutical and Biomedical Analysis  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Turkey  

  • Three/four dimensional chiral HPLC analysis of amino acids in mammals; Their origins, regulation systems and diagnostic values Invited International conference

    Kenji HAMASE, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Jumpei SASABE, Ryuichi KONNO

    33rd International Symposium on Pharmaceutical and Biomedical Analysis  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Turkey  

  • 3 µm微粒子充填Pirkle型固定相の開発とマウス組織におけるD-アスパラギン酸含量の解析

    岡部理子，秋田健行，石井千晴，中川雄太，三田真史，浜瀬健司

    第30回クロマトグラフィーシンポジウム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • 崇高い芳香族アミノ酸を光学中心に有する高分離能Pirkle型キラル固定相の開発

    秋田健行，小柳出麻衣，石井千晴，三田真史，浜瀬健司

    第30回クロマトグラフィーシンポジウム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • 二次元LC-MS/MSシステムを用いるタンパク質中アスパラギン／グルタミン残基のキラル識別微量分析法開発と臨床試料への適用

    石井千晴，竹島華菜子，秋田健行，三田真史，村上祐介，植田　正，浜瀬健司

    第30回クロマトグラフィーシンポジウム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • 脂肪族キラルアミノ酸を対象とする 高選択的三次元HPLC法の開発と ヒト血漿・尿中における含量解析

    永田優凜，秋田健行，石井千晴，小柳出麻衣，三田真史，井手友美，浜瀬健司

    第30回クロマトグラフィーシンポジウム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • 迅速三次元キラルHPLCを用いる腎不全患者血中アスパラギン・セリンの含量解析

    道清祐輝，小柳出麻衣，石井千晴，三田真史，秋田健行，井手友美，木村友則，浜瀬健司

    第30回クロマトグラフィーシンポジウム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • Multi-dimensional HPLC concepts integrating highly efficient enantioselective columns for the analysis of chiral amino acids in complicated real-world samples Invited International conference

    Kenji Hamase, Chiharu ISHII, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER

    51st International Symposium on High Performance Liquid Phase Separations and Related Techniques  2023.6 

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    Event date： 2023.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Germany  

  • Three dimensional HPLC determination of chiral amino acids in the Hayabusa2 return sample from Ryugu International conference

    Aogu FURUSHO, Chiharu ISHII, Takeyuki AKITA, Hiroshi NARAOKA, Kenji HAMASE

    51st International Symposium on High Performance Liquid Phase Separations and Related Techniques  2023.6 

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    Event date： 2023.6

    Language：English  

    Country：Germany  

  • Development of a three-dimensional HPLC system for the determination of hydroxy amino acid enantiomers in the plasma of patients with renal disorder International conference

    Mai OYAIDE, Chiharu ISHII, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tomonori KIMURA, Kenji HAMASE

    51st International Symposium on High Performance Liquid Phase Separations and Related Techniques  2023.6 

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    Event date： 2023.6

    Language：English  

    Country：Germany  

  • Development of an enantioselective three-dimensional HPLC system for the simultaneous determination of aliphatic amino acids in human plasma and urine International conference

    Yuri NAGATA, Takeyuki AKITA, Chiharu ISHII, Mai OYAIDE, Masashi MITA, Tomomi IDE, Kenji HAMASE

    51st International Symposium on High Performance Liquid Phase Separations and Related Techniques  2023.6 

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    Event date： 2023.6

    Language：English  

    Country：Germany  

  • Screening of new diagnostic markers for chronic kidney disease focusing on chiral amino acids using a highly selective two-dimensional LC-MS/MS system International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tomonori KIMURA, Kenji HAMASE

    51st International Symposium on High Performance Liquid Phase Separations and Related Techniques  2023.6 

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    Event date： 2023.6

    Language：English  

    Country：Germany  

  • Asn/Aspおよび Gln/Glu残基のキラル識別微量分析を可能とする重塩酸加水分解・二次元 LC-MS/MS法開発とタンパク質中 D型残基のスクリーニング

    石井千晴，竹島華菜子，秋田健行，三田真史，村上祐介，植田　正，浜瀬健司

    第83回分析化学討論会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：富山   Country：Japan  

  • Three-dimensional HPLC determination of serine/threonine/allo-threonine enantiomers in the plasma of patients with chronic kidney disease International conference

    Mai Oyaide, Chiharu Ishii, Aogu Furusho, Masashi Mita, Takeyuki Akita, Tomomi Ide, Tomonori Kimura, Kenji Hamase

    2023.3 

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    Event date： 2023.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 微粒子充填Pirkle型光学分割カラムの開発とキラルアミノ酸の高性能分離

    岡部理子，秋田健行，石井千晴，中川雄太，三田真史，浜瀬 健司

    日本薬学会第143年会  2023.3 

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    Event date： 2023.3

    Language：Japanese  

    Venue：北海道大学（札幌市）   Country：Japan  

  • フルオラスキラル誘導体化LC-MS法による高選択的アミノ酸分析

    宮里ちひろ，中武樹，川末慎葉，古賀鈴依子，秋田健行，浜瀬健司，吉田秀幸，能田　均

    日本薬学会第143年会  2023.3 

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    Event date： 2023.3

    Language：Japanese  

    Venue：北海道大学（札幌市）   Country：Japan  

  • アスパラギン・セリン鏡像異性体を対象とした迅速三次元HPLC法の開発

    道清祐輝，小柳出麻衣，石井千晴，三田真史，秋田健行，井手友美，浜瀬健司

    日本薬学会第143年会  2023.3 

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    Event date： 2023.3

    Language：Japanese  

    Venue：北海道大学（札幌市）   Country：Japan  

  • アスパラギン/グルタミン鏡像異性体および類縁体を含有するペプチドの分離挙動

    三ノ宮悠介，石井千晴，竹島華菜子，三田真史，秋田健行，浜瀬健司

    日本薬学会第143年会  2023.3 

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    Event date： 2023.3

    Language：Japanese  

    Venue：北海道大学（札幌市）   Country：Japan  

  • Pirkle型固定相によるNBD-アミノ酸光学分割に与える温度の影響

    小園拓歩，古賀夢美，石井千晴，三田真史，秋田健行，浜瀬健司

    日本薬学会第143年会  2023.3 

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    Event date： 2023.3

    Language：Japanese  

    Venue：北海道大学（札幌市）   Country：Japan  

  • 二次元LC-MS/MSを用いるD-システイン残基の微量分析法開発とペプチド・タンパク質中の含量解析

    末吉里絵，石井千晴，秋田健行，三田真史，村上祐介，植田　正，浜瀬健司

    第３３回クロマトグラフィー科学会議  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • メートル長高分離能光学分割カラムを用いるアラニンおよびセリン鏡像異性体の分析

    古賀夢実，古庄　仰，石井千晴，藤井　暁，秋田健行，三田真史，長野正信，井手友美，浜瀬健司

    第３３回クロマトグラフィー科学会議  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • アラニンおよび乳酸鏡像異性体の一斉分析を可能とする二次元HPLC法の開発と実試料における含量解析

    山元一輝，謝　金玲，石井千晴，藤井　暁，秋田健行，三田真史，長野正信，井手友美，浜瀬健司

    第３３回クロマトグラフィー科学会議  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • メートル長逆相カラムを装備した二次元HPLCの開発とキラルアミノ酸およびペプチド分析への適用

    濵田莉那，石井千晴，藤井　暁，秋田健行，三田真史，長野正信，浜瀬健司

    第３３回クロマトグラフィー科学会議  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 高分離能二次元キラルLC-MS/MSを用いるタンパク質中Asn/AspおよびGln/Glu残基分析

    竹島華菜子，石井千晴，秋田健行，浜本　洋，三田真史，関水和久，村上祐介，植田　正，浜瀬健司

    第３３回クロマトグラフィー科学会議  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 多次元キラルHPLC法による慢性腎臓病の新規診断マーカー探索と実用化の展開

    石井千晴，古庄　仰，山﨑千夏，秋田健行，三田真史，井手友美，木村友則，浜瀬健司

    第６２回日本臨床化学会年次学術集会  2022.10 

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    Event date： 2022.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：富山市   Country：Japan  

  • 高選択的三次元HPLC分析法の設計開発と実試料中のキラルアミノ酸分析

    永田優凜，古庄　仰，石井千晴，秋田健行，三田真史，浜瀬健司

    第19回次世代を担う若手のためのフィジカル・ファーマフォーラム  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 生体・食品におけるSer/Thr/aThrの光学識別微量分析を可能とする三次元HPLC法の開発

    小柳出麻衣，石井千晴，古庄　仰，秋田健行，藤井　暁，三田真史，長野正信，井手友美，浜瀬健司

    第19回次世代を担う若手のためのフィジカル・ファーマフォーラム  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Selective determination of D-amino acids in the rat plasma and urine using a two-dimensional LC-MS/MS system and their regulation by D-amino acid oxidase International conference

    Chiharu ISHII, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tadashi OKAMURA, Kenji HAMASE

    12th International symposium on drug analysis & 32nd International symposium on pharmaceutical and biomedical analysis  2022.9 

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    Event date： 2022.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Belgium  

  • Ser/Thr/aThrのキラル識別分析を可能とする高選択的三次元HPLC法の開発とヒト血中含量の解析

    小柳出麻衣，石井千晴，古庄　仰，秋田健行，三田真史，井手友美，浜瀬健司

    第34回バイオメディカル分析科学シンポジウム  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本大学（船橋市）   Country：Japan  

  • 高選択的三次元HPLCの開発を目的とした新規ミックスモードカラムの設計とNBD-アミノ酸鏡像異性体の分析

    永田優凜，古庄　仰，石井千晴，秋田健行，三田真史，浜瀬健司

    第34回バイオメディカル分析科学シンポジウム  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本大学（船橋市）   Country：Japan  

  • 二次元HPLCを用いる発酵食品中のヒスチジンおよびアルギニン鏡像異性体の分析

    長谷川美優，石井千晴，秋田健行，藤井　暁，三田真史，長野正信，浜瀬健司

    九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Simultaneous determination of chiral amino acids in the plasma and brain of DAO deficient rats using a highly selective two-dimensional LC-MS/MS system International conference

    Chiharu ISHII, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tadashi OKAMURA, Kenji HAMASE

    The 5th International conference of D-amino acid research  2022.7 

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    Event date： 2022.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • アラニンおよび乳酸の光学識別一斉分析を可能とする二次元HPLC法開発と実試料への適用

    山元一輝，謝　金玲，石井千晴，秋田健行，三田真史，長野正信，井手友美，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • 微粒子充填型メートル長逆相カラムの分離能評価およびキラルアミノ酸分析への適用

    濵田莉那，石井千晴，秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • メートル長光学分割カラムを用いる黒酢中のキラルアミノ酸分析

    古賀夢美，中川雄太，石井千晴，藤井　暁，秋田健行，三田真史，長野正信，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • D-アミノ酸の微量分析を可能とする新規高性能Pirkle型キラル固定相の開発

    中川雄太，石井千晴，秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • Pirkle型キラル固定相を用いるロイシン/イソロイシン/アロイソロイシン鏡像異性体の一斉分析

    山部真弓，石井千晴，秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • 高選択的多次元HPLCの開発を目的とした新規ミックスモードカラムの作製とNBD-アミノ酸の保持挙動評価

    永田優凜，古庄　仰，石井千晴，秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • 塩基性アミノ酸を対象とする二次元キラルHPLC分析法開発と発酵食品における含量解析

    長谷川美優，石井千晴，秋田健行，藤井　暁，三田真史，長野正信，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • 二次元HPLCを用いる黒酢中ヒドロキシアミノ酸鏡像異性体の分析

    小柳出麻衣，石井千晴，藤井　暁, 秋田健行，三田真史，長野正信，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • 二次元LC-MS/MSを用いるAsn/AspおよびGln/Glu残基のキラル識別微量分析法開発とペプチド試料への適用

    竹島華菜子，石井千晴，秋田健行，浜本　洋，三田真史，関水和久，植田　正，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • システイン残基のキラル識別微量分析を可能とする二次元LC-MS/MS法開発とタンパク質試料への適用

    末吉里絵，石井千晴，秋田健行，三田真史，植田　正，浜瀬健司

    第29回クロマトグラフィーシンポジウム  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣市民会館（石垣市）   Country：Japan  

  • Development of an enantioselective three-dimensional HPLC system for the determination of lactate, hydroxybutyrates and malate in human urine

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    2022.6 

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    Event date： 2022.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 直鎖脂肪族アミノ酸を有するPirkle型固定相の開発とNBD-アミノ酸鏡像異性体の分離

    中川雄太，梶原雅貴，秋田健行，石井千晴，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • セリンおよびアスパラギン酸の高選択的三次元キラルHPLC分析法開発とヒト血中含量解析

    梶原雅貴、秋田健行、石井千晴、三田真史、井手友美、浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • ヒト血液および尿中におけるヒドロキシアミノ酸鏡像異性体の高分離能二次元HPLC分析法開発

    小柳出麻衣、古庄仰、石井千晴、秋田健行、三田真史、井手友美、浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 二次元キラルHPLCを用いるアラニン、アスパラギン酸、セリン、乳酸および3-ヒドロキシ酪酸の同時分析法開発

    坂元瞭太，謝　金玲，山元一輝，石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 二次元LC-MS/MSを用いるシステイン残基のキラル識別微量分析法開発とタンパク質・ペプチドへの適用

    末吉里絵，石井千晴，秋田健行，三田真史，植田　正，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Asn/AspおよびGln/Glu残基を対象とする二次元キラルLC-MS/MS微量分析法開発と実試料における含量解析

    竹島華菜子，石井千晴，秋田健行，浜本　洋，三田真史，関水和久，植田　正，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 塩基性アミノ酸を対象とする高選択的二次元キラルHPLC分析法の開発

    長谷川美優，守永　麟，石井千晴，秋田健行，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 高性能Pirkle型キラル固定相を用いるグリシン含有ジペプチドの光学分割

    横谷昌祐，秋田健行，山﨑千夏，石井千晴，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 各種Pirkle型キラル固定相におけるロイシン連鎖異性体の分離挙動解析

    山部真弓，石井千晴，秋田健行，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 光リアクター搭載二次元HPLCを利用するNBD-Trp鏡像異性体の高感度分析法開発

    山下愛絵，石井千晴，古庄　仰，秋田健行，根岸栄一，井本啓史，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • キラルアミノ酸の高選択的三次元HPLC分析を目的とする新規ミックスモードカラムの開発

    永田優凜，古庄　仰，石井千晴，秋田健行，三田真史，浜瀬健司

    日本薬学会第142年会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Determination of plasma D-amino acids in human and laboratory rodents with various D-amino acid oxidase activities using a two-dimensional HPLC-MS/MS system International conference

    Chiharu ISHII, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tadashi OKAMURA, Kenji HAMASE

    2021 International Congress of Pacific Basin Scieties (PACIFICHEM 2021)  2021.12 

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    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • ヒト血中セリンおよびアスパラギン鏡像異性体の迅速二次元HPLC分析法開発と慢性腎臓病早期診断への適用 Invited

    山﨑千夏，石井千晴，秋田健行，三田真史，井手友美，木村友則，浜瀬健司

    第32回クロマトグラフィー科学会議  2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：野田   Country：Japan  

  • 臨床診断を目的としたキラルアミノ酸の網羅的三次元HPLC分析法開発と新規腎機能マーカー探索への適用 Invited

    古庄　仰，石井千晴，秋田健行，三田真史，井手友美，木村友則，浜瀬健司

    第32回クロマトグラフィー科学会議  2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：野田   Country：Japan  

  • 三次元HPLCを用いる微量酸性D-アミノ酸分析法開発と哺乳類における内在性含量の解析 Invited

    守永　麟，古庄　仰，石井千晴，秋田健行，三田真史，浜瀬健司

    第32回クロマトグラフィー科学会議  2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：野田   Country：Japan  

  • Enantioselective determination of lactate in vinegars including Japanese traditional kurozu samples and the developmental changes during fermentation processes

    Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Akira FUJII, Masanobu NAGANO, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 芳香族アミノ酸を有する新規高分離能Pirke型キラル固定相の開発とNBD-アミノ酸の光学分割

    小柳出麻衣，秋田健行，梶原雅貴，古庄　仰，石井千晴，三田真史，浜瀬健司

    第33回バイオメディカル分析科学シンポジウム  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • Enantioselective determination of lactate, hydroxybutyrates and malate in mammalian plasma using a two-dimensional chiral HPLC system International conference

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

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    Event date： 2021.8 - 2021.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Development of a two-dimensional LC-MS/MS system for the selective determination of intrinsic chiral amino acids and application to mammalian plasma International conference

    Chiharu ISHII, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tadashi OKAMURA, Kenji HAMASE

    31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

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    Event date： 2021.8 - 2021.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Development of a highly sensitive and selective three-dimensional HPLC system for the determination of chiral amino acids in carbonaceous meteorites International conference

    Aogu FURUSHO, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE

    31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

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    Event date： 2021.8 - 2021.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Enantioselective determination of lactate in various food samples including Japanese traditional amber rice vinegar and the developmental changes during fermentation processes International conference

    Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Akira FUJII, Masanobu NAGANO, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

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    Event date： 2021.8 - 2021.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Development of a high-performance three-dimensional HPLC system for the determination of Ser and Asp enantiomers in human physiological fluids International conference

    Masataka KAJIWARA, Takeyuki AKITA, Chiharu ISHII, Masashi MITA, Tomomi IDE, Kenji HAMASE

    31st International Symposium on Pharmaceutical and Biomedical Analysis  2021.8 

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    Event date： 2021.8 - 2021.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 3D-HPLC Determination of Lactic Acid Enantiomers in Food Samples and Alteration of Their Amounts in the Plasma After Ingesting Fermented Products

    Chin-Ling Hsieh, Takeyuki Akita, Masanobu Nagano, Masashi Mita, Tomomi Ide, Jen-Ai Lee, Kenji Hamase

    2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 臨床診断を目的としたヒト血中・尿中キラルアミノ酸の網羅的三次元HPLC分析法開発

    古庄仰，秋田健行，三田真史，井手友美，浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • タンパク質におけるAsn/Asp及びGln/Gluの一斉識別を可能とする二次元キラルLC-MS/MS法の開発

    田川茂奈，石井千晴，秋田健行，浜本洋，三田真史, 関水和久，植田正，浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • ヒト血中キラルアミノ酸の精密定量を可能とする二次元LC-MS/MS法開発と腎機能診断への適用

    石井千晴，秋田健行，三田真史, 木村友則，井手友美，浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • 二次元HPLC-MS/MSシステムによるヒトおよびD-アミノ酸酸化酵素欠損マウスの血漿中キラルアミノ酸含量解析

    石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    第27回クロマトグラフィーシンポジウム  2020.6 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：誌上開催   Country：Japan  

  • 種々の地球外試料におけるキラルアミノ酸の三次元HPLC分析

    古庄　仰，秋田健行，三田真史，奈良岡　浩，浜瀬健司

    第27回クロマトグラフィーシンポジウム  2020.6 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：誌上開催   Country：Japan  

  • 三次元HPLCを用いる黒酢およびヒト血漿における乳酸鏡像異性体の定量

    謝　金玲，秋田健行，長野正信，三田真史，井手友美，李　仁愛，浜瀬健司

    第27回クロマトグラフィーシンポジウム  2020.6 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：誌上開催   Country：Japan  

  • Two-dimensional HPLC-MS/MS determination of intrinsic chiral amino acids in the plasma of mammals with various D-amino acid oxidase activities International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

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    Event date： 2019.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 含硫アミノ酸光学異性体の三次元HPLC分析法開発と哺乳類血中および尿中含量解析

    佐藤根詩織，秋田健行，三田真史，井手友美，浜瀬健司

    第30回クロマトグラフィー科学会議  2019.12 

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    Event date： 2019.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • Enantioselective three-dimensional HPLC determination of amino acids in carbonaceous meteorites International conference

    Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE

    49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

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    Event date： 2019.12

    Language：Japanese  

    Country：Japan  

  • Development of a validated three-dimensional chiral HPLC system for the determination of lactate and 3-hydroxybutyrate in human plasma International conference

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    49th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2019.12 

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    Event date： 2019.12

    Language：Japanese  

    Country：Japan  

  • Chiral recognition mechanism of Pirkle-type stationary phases in D-amino acid analyses International conference

    Takeyuki AKITA, Natsuki YOSHIOKA, Masashi MITA, Kenji HAMASE

    The 4th International Conference of D-Amino Acid Research  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Development of a highly selective two-dimensional HPLC-MS/MS system for the screening of intrinsic D-amino acids in human clinical samples

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    30th International Symposium on Pharmaceutical and Biomedical Analysis  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Israel  

  • Rapid two-dimensional HPLC analysis of D-serine in the human plasma using a high-performance chiral stationary phase International conference

    Natsuki YOSHIOKA, Shoto ISHIGO, Takeyuki AKITA, Masashi MITA, Kenji HAMASE

    The 4th International Conference of D-Amino Acid Research  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Enantioselective analysis of lactate and 3-hydroxybutyrate in human samples using a selective and stable 3D-HPLC system International conference

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    The 4th International Conference of D-Amino Acid Research  2019.9 

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    Event date： 2019.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Design and development of a highly selective chiral 3D-HPLC system for the determination of lactate and 3-hydroxybutyrate enantiomers in human physiological fluids International conference

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    31st International Symposium on Chirality  2019.7 

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    Event date： 2019.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：France  

  • キラルアミノ酸分析におけるPirkle型固定相の分子認識機構解析

    秋田健行，吉岡夏輝，山崎千夏，三田真史，浜瀬健司

    第56回化学関連支部合同九州大会  2019.7 

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    Event date： 2019.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • Three-dimensional chiral HPLC analysis of extraterrestrial amino acids in carbonaceous chondrites International conference

    Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE

    48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques  2019.6 

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    Event date： 2019.6

    Language：English  

    Country：Italy  

  • A novel fluorescence derivatizing reagent for chiral amino acid metabolome analysis including tryptophan with high emission intensity International conference

    Takeyuki AKITA, Asumi YOSHIDA, Masashi MITA, Akio OJIDA, Kenji HAMASE

    15th Conference of the International Society of Tryptophan Research  2018.9 

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    Event date： 2018.9

    Language：English  

    Country：Japan  

  • Chiral amino acid metabolomics studies using two/three-dimensional HPLC for the screening of new biomarkers and designing functional foods/beverages International conference

    Kenji HAMASE, Chiharu ISHII, Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Tomonori KIMURA, Wolfgang LINDNER

    The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis  2018.9 

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    Event date： 2018.9

    Language：English  

    Country：Belgium  

  • Development and validation of an on-line two-dimensional HPLC-MS/MS system for the determination of intrinsic chiral amino acids in human physiological fluids International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis  2018.9 

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    Event date： 2018.9

    Language：English  

    Country：Belgium  

  • Design and development of multi-mode HPLC stationary phases for chiral separation of amino acids and related compounds Invited International conference

    Takeyuki AKITA, Kenji UEKI, Masashi MITA, Kenji HAMASE

    25th International Symposium on Electro-and Liquid Phase-Separation Techniques  2018.8 

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    Event date： 2018.8 - 2018.9

    Language：English  

    Country：Japan  

  • Three-dimensional chiral HPLC analysis of amino acids and related compounds in complex biological matrices including human clinical samples International conference

    Kenji HAMASE, Reiko KOGA, Aogu FURUSHO, Chin-Ling HSIEH, Nutchaya SEREEKITTIKUL, Takeyuki AKITA, Masashi MITA, Tomomi IDE,Jen-Ai LEE, Wolfgang LINDNER

    47th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2018.8 

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    Event date： 2018.7 - 2018.8

    Language：English  

    Country：United States  

  • Three-dimensional HPLC analysis of chiral amino acids in the plasma of patients with chronic kidney disease International conference

    Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE

    47th International Symposium on High Performance Liquid Phase Separations and Related Techniques  2018.7 

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    Event date： 2018.7 - 2018.8

    Language：English  

    Country：United States  

  • Development of a Two-Dimensional Chiral HPLC System for Leucine Structural Isomers and Determination of Their Urinary Levels International conference

    Kenta SAKAI, Kenji UEKI, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Ryuichi KONNO, Tomomi IDE, Kenji HAMASE

    HPLC 2017 Jeju  2017.11 

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    Event date： 2017.11

    Language：English  

    Country：Korea, Republic of  

  • Design and Development of a Three-Dimensional HPLC System for Chiral Amino Acid Analysis in Human Clinical Samples International conference

    Aogu FURUSHO, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    HPLC 2017 Jeju  2017.11 

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    Event date： 2017.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Multi-Dimensional Chiral HPLC Analysis of Amino Acids in Clinical Samples and Extraterrestrial Materials International conference

    Kenji HAMASE, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Wolfgang Lindner

    HPLC 2017 Jeju  2017.11 

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    Event date： 2017.11

    Language：English  

    Country：Korea, Republic of  

  • Development of high resolution Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices International conference

    Kenji UEKI, Takeyuki AKITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio Ojida, Kenji HAMASE

    HPLC 2017 PRAGUE  2017.6 

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    Event date： 2017.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Czech Republic  

  • 新規Pirkle型キラル固定相の設計・作製とNBD-アミノ酸／ジペプチドの分離特性解析

    植木　健治, 秋田 健行, 門田　靖彦, 西尾　康弘, 三田　真史, 濵瀬健司

    第２４回クロマトグラフィーシンポジウム  2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：仙台   Country：Japan  

  • トリプトファンNBD誘導体の高感度蛍光キラルHPLC分析法開発

    吉田　あすみ, 秋田 健行, 古賀 鈴依子, 植木　健治, 佐藤　裕, 三田　真史, 濵瀬健司

    日本薬学会　第１３７年会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：仙台   Country：Japan  

  • ACCELERATION OF REACTION BETWEEN TWO MOIETIES ON THE SURFACES OF SPIONS BY STATIC MAGNETIC FIELDS International conference

    Takeyuki AKITA

    XVII International Symposium on Luminescence Spectrometry  2016.11 

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    Event date： 2016.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Taiwan, Province of China  

  • DESIGN OF A NOVEL HIGH RESOLUTION PIRKLE-TYPE CHIRAL STATIONARY PHASE AND SEPARATION OF NBD-AMINO ACID ENANTIOMERS International conference

    Kenji UEKI, Takeyuki AKITA, Yu SATO, Reiko KOGA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE

    XVII International Symposium on Luminescence Spectrometry  2016.11 

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    Event date： 2016.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Taiwan, Province of China  

  • SPION表面保護ポリマーに導入した官能基間の反応と磁場効果

    秋田 健行, 古賀 登

    第２４回基礎有機化学討論会  2013.9 

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    Event date： 2013.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

    反応を磁場で制御する試みは以前より行われているが、一般的な反応に広範に応用が可能な方法論については未だに確立されていない。そこで今回、超常磁性酸化鉄ナノパーティクル（SPION）の表面保護ポリマーにそれぞれ反応が可能な官能基を導入した二種類のSPIONを用い、磁場によりSPION間の距離をコントロールすることにより反応を制御することを試みた。

  • Pd触媒を導入したSPIONを用いたSPIONからの機能分子の放出反応の検討

    秋田健行・古賀登

    日本化学会第92春季年会  2012.3 

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    Event date： 2012.3

    Presentation type：Oral presentation (general)  

    Venue：慶応大学日吉キャンパス   Country：Japan  

    パラジウム触媒を表面に導入した超常磁性鉄酸化物ナノパーティクル（SPION）1を合成し、これを用いて、ブテニルエーテルを介してフルオレセイン誘導体を導入したSPION 2からの蛍光分子の放出反応について検討を行った。

  • 超常磁性酸化鉄ナノパーティクル表面への蛍光性物質の導入と放出反応の検討

    秋田　健行・古賀　登

    第２２回基礎有機化学討論会  2011.9 

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    Event date： 2011.9

    Presentation type：Oral presentation (general)  

    Venue：つくば国際会議場   Country：Japan  

    超常磁性酸化鉄ナノパーティクルは近年、ドラッグデリバリーシステム（DDS）やMRI造影剤等の生体内イメージング剤への応用が期待され、盛んに研究が行われている。その際にSPION表面への機能性分子の導入と、生体内環境や外部からの刺激による機能性分子の選択的な放出の機構が重要となる。本研究では機能分子のモデルとしてフルオレセイン誘導体及びニトロフェノールを用い、アミノブテニルリンカーを通した機能性分子の表面保護部への導入と、Pd(0)によるアリールエーテル部位の切断反応を用いた選択的放出反応について検討を行った。

  • Pirkle型カラムにおける分析温度変更とNBD-アミノ酸鏡像異性体の分離挙動

    小園拓歩，小柳出麻衣，石井千晴，三田真史，秋田健行，浜瀬健司

    九州分析化学若手の会 第36回若手研究講演会および第41回夏季セミナー  2023.7 

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • キラルアミノ酸の網羅的微量分析を可能とする新規Pirkle型固定相の開発

    中川雄太，石井千晴，秋田健行，三田真史，浜瀬健司

    九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • セリンおよびスレオニンの光学識別微量分析法開発と生体・食品における含量解析

    小柳出麻衣，石井千晴，秋田健行，藤井　暁，三田真史，長野正信，井手友美，浜瀬健司

    九州分析化学若手の会第35回若手研究講演会および第40回夏季セミナー  2022.7 

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 臨床診断を目的としたキラルアミノ酸の多次元HPLC法開発とヒト血液・尿中における含量解析 Invited

    古庄　仰，石井千晴，秋田健行，三田真史，木村友則，井手友美，浜瀬健司

    第69回質量分析総合討論会  2021.5 

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    Event date： 2022.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • キラルアミノ酸の高選択的三次元HPLC分析を目的とする新規ミックスモードカラムの開発

    永田 優凜, 古庄 仰, 石井 千晴, 秋田 健行, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Event date： 2022.3

    Language：Japanese  

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  • 光リアクター搭載二次元HPLCを利用するNBD-Trp鏡像異性体の高感度分析法開発

    山下 愛絵, 石井 千晴, 古庄 仰, 秋田 健行, 根岸 栄一, 井本 啓史, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Event date： 2022.3

    Language：Japanese  

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  • ヒト血液および尿中におけるヒドロキシアミノ酸鏡像異性体の高分離能二次元HPLC分析法開発

    小柳出 麻衣, 古庄 仰, 石井 千晴, 秋田 健行, 三田 真史, 井手 友美, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Event date： 2022.3

    Language：Japanese  

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  • Two-dimensional chiral HPLC analysis of lactate, hydroxybutyrates and malate in mammalian physiological fluids and food samples

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 内在性キラルアミノ酸の選択的定量を可能とする二次元LC-MS/MSシステムの開発と哺乳類血中における含量解析

    石井千晴，清水有紀子，秋田健行，三田真史，井手友美，岡村匡史，浜瀬健司

    クロマトグラフィー次世代技術セミナー2021  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣   Country：Japan  

  • タンパク質中Asn/AspおよびGln/Glu残基の微量分析を可能とする高分離能二次元キラルLC-MS/MS法開発

    竹島華菜子，石井千晴，秋田健行，三田真史，植田　正，浜瀬 健司

    クロマトグラフィー次世代技術セミナー2021  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣   Country：Japan  

  • 微量地球外試料におけるキラルアミノ酸分析を可能とする高選択的三次元HPLC法の開発

    古庄　仰，石井千晴，秋田健行，三田真史，奈良岡　浩，浜瀬健司

    クロマトグラフィー次世代技術セミナー2021  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石垣   Country：Japan  

  • タンパク質中のシステイン残基を対象とするキラル識別微量分析法開発

    末吉里絵，石井千晴，秋田健行，三田真史，植田 正，浜瀬健司

    第33回バイオメディカル分析科学シンポジウム  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 高選択的三次元HPLC分析法の開発と生体・宇宙試料におけるキラルアミノ酸精密定量

    古庄　仰，石井千晴，秋田健行，三田真史，井手友美，木村友則，奈良岡　浩，浜瀬健司

    第16回D-アミノ酸学会学術講演会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 哺乳類血中キラルアミノ酸の精密定量を可能とする二次元LC-MS/MS法の開発とD-アミノ酸酸化酵素欠損による含量変化

    石井千晴，清水有紀子，秋田健行，三田真史，井手友美，岡村匡史，金野柳一，浜瀬健司

    第16回D-アミノ酸学会学術講演会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • タンデムカラム二次元HPLCを用いるヒト血中セリン鏡像異性体の分析

    山﨑千夏，石井千晴，秋田健行，三田真史，井手友美，浜瀬 健司

    第28回クロマトグラフィーシンポジウム  2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Development of a two-dimensional chiral HPLC system for the simultaneous determination of lactate, hydroxybutyrates and malate

    Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 二次元LC-MS/MSシステムを用いる哺乳類血中キラルアミノ酸の精密含量解析

    石井千晴，清水有紀子，秋田健行，三田真史，井手友美，岡村 匡史，浜瀬 健司

    第28回クロマトグラフィーシンポジウム  2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 宇宙アミノ酸を対象とする三次元キラルHPLC分析法の開発と炭素質隕石試料への適用

    古庄　仰，石井千晴，秋田健行，三田真史，奈良岡　浩，浜瀬健司

    第28回クロマトグラフィーシンポジウム  2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Enantioselective analysis of lactate in Japanese traditional amber rice vinegar and the developmental changes during fermentation processes

    Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Akira FUJII, Masanobu NAGANO, Masashi MITA, Jen-Ai LEE, Kenji HAMASE

    2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • タンパク質／ペプチドにおけるプロリン残基および４位水酸化体の二次元キラルLC-MS/MS分析法開発

    岩崎孔明, 石井千晴, 秋田健行, 東條洋介, 三田真史, 植田正, 浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • 塩基性アミノ酸の三次元キラルHPLC分析法開発と哺乳類尿中含量の解析

    植木大和，古庄　仰，吉岡夏輝，秋田健行，三田真史，井手友美，浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • 三次元HPLCを用いる哺乳類体内の微量酸性D-アミノ酸分析

    守永麟，古庄仰，吉岡夏輝，秋田健行，三田真史, 浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • キラルアミノ酸の迅速かつ選択的多次元HPLC分析を可能とする高性能Pirkle型固定相の開発

    梶原雅貴，吉岡夏輝，秋田健行，三田真史, 浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • タンデム光学分割カラムを利用するロイシン連鎖異性体の二次元HPLCキラル一斉分析法の開発

    堀田直利，酒井健多，秋田健行，三田真史, 浜瀬健司

    第31回クロマトグラフィー科学会議  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：静岡   Country：Japan  

  • 塩基性アミノ酸を対象とした三次元キラルHPLC分析法の高性能化とヒト尿中含量の解析

    植木大和，古庄　仰，吉岡夏輝，秋田健行，三田真史，井手友美，浜瀬健司

    第27回クロマトグラフィーシンポジウム  2020.6 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：誌上開催   Country：Japan  

  • Determination of D-amino acids in fermented products using an automated two-dimensional HPLC-MS/MS system International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Kenji HAMASE

    35th International Annual Meeting in Pharmaceutical Sciences (IAMPS35) and CU-MPU International Collaborative Research Conference  2019.3 

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    Event date： 2020.6

    Language：English  

    Country：Thailand  

  • Development of a three-dimensional HPLC system for the determination of acidic amino acid enantiomers in human physiological fluids International conference

    Miho TAKAHASHI, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    35th International Annual Meeting in Pharmaceutical Sciences (IAMPS35) and CU-MPU International Collaborative Research Conference  2019.3 

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    Event date： 2020.6

    Language：English  

    Country：Thailand  

  • Development of an online two-dimensional HPLC system for leucine skeletal isomers and their enantioselective determination in mammals International conference

    Kenta SAKAI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    35th International Annual Meeting in Pharmaceutical Sciences (IAMPS35) and CU-MPU International Collaborative Research Conference  2019.3 

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    Event date： 2020.6

    Language：English  

    Country：Thailand  

  • Development of a two-dimensional HPLC system for the analysis of β-alanine, γ-aminobutyric acid and related amino acid enantiomers in Japanese traditional black vinegar (Kurozu) International conference

    2019.3 

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    Event date： 2020.6

    Language：English  

    Venue：Bangkok   Country：Thailand  

  • Two-dimensional HPLC separation of D-Ser, D-Ala and D-Asp in human physiological fluids and fermented products using a high performance Pirkle-type enantioselective column International conference

    Chidchanok RUJIRACHATKUL, Natsuki YOSHIOKA, Takeyuki AKITA, Masanobu NAGANO, Masashi MITA, Tomomi IDE, Boonchoo SRITULARAK, Kenji HAMASE

    35th International Annual Meeting in Pharmaceutical Sciences (IAMPS35) and CU-MPU International Collaborative Research Conference  2019.3 

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    Event date： 2020.6

    Language：English  

    Country：Thailand  

  • 生体内酸性D-アミノ酸の微量分析を可能とする三次元HPLC法開発

    守永　麟，吉岡夏輝，古庄　仰，秋田健行，三田真史，浜瀬健司

    日本薬学会第140年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • NBD-トリプトファンの二次元キラルLC-MS/MS分析法開発と哺乳類体内含量の解析

    瀧澤宣郎，石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    日本薬学会第140年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 高性能Pirkle型キラル固定相の開発とNBD-アミノ酸の光学分割能評価

    梶原雅貴，吉岡夏輝，秋田健行，三田真史，浜瀬健司

    日本薬学会第140年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 哺乳類体内の微量D-セリン分析を目的とするタンデムカラム二次元キラルHPLC法開発

    山﨑千夏，吉岡夏輝，秋田健行，三田真史，井手友美，浜瀬健司

    日本薬学会第140年会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 2,4-(Dimethoxycarbonyl)phenyl 10-methyl-10λ4-acridine- 9-carboxylateを用いるコリンの化学発光定量法

    中園　学，南部伸孝，秋田健行，浜瀬健司

    生物発光化学発光研究会第34回学術講演会  2018.10 

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    Event date： 2020.2

    Language：Japanese  

    Country：Japan  

  • 二次元HPLC-MS/MSを用いるD-アミノ酸の高選択的スクリーニング法開発とヒト血漿および尿中含量の解析

    石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    第14回D-アミノ酸学会学術講演会  2018.9 

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    Event date： 2020.2

    Language：Japanese  

    Venue：Toyama   Country：Japan  

  • 多次元キラルHPLC分析を指向した保持力制御型固定相の開発

    吉岡夏輝，酒井健多，秋田健行，三田真史，浜瀬健司

    第14回D-アミノ酸学会学術講演会  2018.9 

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    Event date： 2020.2

    Language：Japanese  

    Venue：富山   Country：Japan  

  • ヒト臨床試料中における酸性キラルアミノ酸分析を可能とする三次元HPLCシステムの開発

    高橋美帆,古庄　仰,秋田健行,三田真史,井手友美,浜瀬健司

    第14回D-アミノ酸学会学術講演会  2018.9 

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    Event date： 2020.2

    Language：Japanese  

    Venue：富山   Country：Japan  

  • フェニル部位に複数個のハロゲンを有するアクリジニウムエステル

    中園　学，南部伸孝，秋田健行，浜瀬健司

    生物発光化学発光研究会第34回学術講演会  2018.10 

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    Event date： 2020.2

    Language：Japanese  

    Country：Japan  

  • 2,4-Disubstituted phenyl 10-methyl-10λ4-acridine-9-carboxylateの化学発光

    中園　学，南部伸孝，秋田健行，浜瀬健司

    生物発光化学発光研究会第34回学術講演会  2018.10 

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    Event date： 2020.2

    Language：Japanese  

    Country：Japan  

  • 新規蛍光誘導体化試薬NBD-COOSuを用いるキラルアミノ酸の三次元HPLC分析法開発と哺乳類体内含量の解析

    二井屋田美樹，秋田健行，三田真史，浜瀬健司

    第30回クロマトグラフィー科学会議  2019.12 

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    Event date： 2019.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 2D-HPLC determination of serine, alanine and aspartic acid enantiomers as their DBD derivatives in the human physiological fluids and food samples

    Karina Akemy IKEJIRI, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    2019.12 

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    Event date： 2019.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • アクリジニウムエステル誘導体化学発光：アクリジン部位2及び7位の置換基効果

    中園　学，南部伸孝，秋田健行，浜瀬健司

    生物発光化学発光研究会第35回学術講演会  2019.10 

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    Event date： 2019.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 臨床試料におけるキラルアミノ酸高選択的スクリーニングを可能とする二次元HPLC-MS/MSシステムの開発

    石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    第17回次世代を担う若手のためのフィジカル・ファーマフォーラム  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大津   Country：Japan  

  • Determination of phenylalanine enantiomers in mammalian plasma and urine using two-dimensional HPLC

    Sui-Wen HSIAO, Chiharu ISHII, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Ching-Kuo LEE, Kenji HAMASE

    2019.8 

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    Event date： 2019.8

    Language：Japanese  

    Country：Japan  

  • キラルアミノ酸の高選択的二次元HPLC-MS/MS法開発と臨床・食品・タンパク質試料への適用

    石井千晴，秋田健行，長野正信，三田真史，井手友美，浜瀬健司

    第32回バイオメディカル分析科学シンポジウム  2019.8 

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    Event date： 2019.8

    Language：Japanese  

    Venue：西東京   Country：Japan  

  • Multi-dimensional HPLC analysis of chiral α-amino acids and carboxylic acids in extraterrestrial materials International conference

    2019.7 

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    Event date： 2019.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Bordeaux   Country：France  

  • 鏡像異性体を識別する全自動二次元HPLC-MS/MSシステムの開発と発酵食品におけるキラルアミノ酸の高選択的含量解析

    石井千晴，秋田健行，長野正信，三田真史，浜瀬健司

    モレキュラー・キラリティー2019  2019.6 

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    Event date： 2019.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢   Country：Japan  

  • ロイシン連鎖異性体のキラル一斉分析を可能とする固定相の探索と分離条件の確立

    堀田直利，吉岡夏輝，酒井健多，秋田健行，三田真史，浜瀬健司

    第37回九州分析化学若手の会　夏季セミナー  2019.7 

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    Event date： 2019.7

    Language：Japanese  

    Venue：唐津   Country：Japan  

  • 三次元HPLCを用いる哺乳類尿中塩基性アミノ酸のキラル識別分析

    植木大和，古庄　仰，吉岡夏輝，秋田健行，三田真史，浜瀬健司

    第37回九州分析化学若手の会　夏季セミナー  2019.7 

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    Event date： 2019.7

    Language：Japanese  

    Venue：唐津   Country：Japan  

  • Multi-dimensional HPLC determination of lactate and 3-hydroxybutyrate enantiomers and application to human physiological fluids

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    2019.7 

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    Event date： 2019.7

    Language：Japanese  

    Country：Japan  

  • Enantioselective determination of lactate and 3-hydroxybutyrate in human clinical samples using a 3D-HPLC system

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    2019.7 

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    Event date： 2019.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • アルカリ及び触媒の添加を必要としないH2O2の化学発光測定

    中園　学，南部伸孝，秋田健行，浜瀬健司

    第56回化学関連支部合同九州大会  2019.7 

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    Event date： 2019.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • Three-dimensional HPLC determination of lactate and 3-hydroxybutyrate enantiomers in mammalian urine

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 塩基性アミノ酸を対象とした三次元キラルHPLC分析法の開発

    植木大和，古庄　仰，吉岡夏輝，秋田健行，三田真史，浜瀬健司

    第26回クロマトグラフィーシンポジウム  2019.6 

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    Event date： 2019.6

    Language：Japanese  

    Venue：岡山   Country：Japan  

  • 三次元HPLCを用いる地球外試料中のキラルアミノ酸分析

    古庄　仰，秋田健行，三田真史，奈良岡　浩，浜瀬健司

    第79回分析化学討論会  2019.5 

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • 高性能二次元キラルHPLCを用いるヒト血中D-Serの迅速分析

    吉岡夏輝，石郷翔人，秋田健行，三田真史，浜瀬健司

    第79回分析化学討論会  2019.5 

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • 疎水性アミノ酸を対象とする三次元キラルHPLC分析法の開発

    田中優光，秋田健行，三田真史，浜瀬健司

    第79回分析化学討論会  2019.5 

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • Development of a fully automated two-dimensional HPLC-MS/MS system for the determination of amino acid enantiomers in human physiological fluids and fermented beverages International conference

    Chiharu ISHII,Masashi MITA,Takeyuki AKITA,Tomomi IDE,Kenji HAMASE

    34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium  2018.3 

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    Event date： 2019.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Thailand  

  • Two-dimensional HPLC analysis of Asp-Gly and Gly-Asp enantiomers in human samples and fermented products International conference

    Siralak LAORATANAPONG,Nutchaya SEREEKITTIKUL,Kenji UEKI,Takeyuki AKITA,Masashi MITA,Tomomi IDE,Boonchoo SRITULARAK,Kenji HAMASE

    34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium  2018.3 

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    Event date： 2019.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Thailand  

  • ヒト血漿及び尿中D-アミノ酸の高選択的一斉分析を可能とするオンライン二次元キラルHPLC-MS/MSシステムの開発

    石井千晴, 秋田健行, 三田真史, 井手友美 , 浜瀬健司

    日本薬学会第139年会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：千葉   Country：Japan  

  • アリールニトロキシドとアリールボロン酸を用いた新規錯体の合成・構造と磁気的性質

    込宮良輔、篠本倖太、秋田健行，小林啓二、榎本真哉、秋田素子

    第２２回有機結晶シンポジウム  2013.11 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • プロリンおよび4位水酸化体の二次元キラルHPLC-MS/MS分析法開発

    岩﨑孔明, 石井千晴, 秋田健行, 三田真史, 井手友美, 浜瀬健司

    日本薬学会第139年会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：千葉   Country：Japan  

  • タンパク質中のグルタミン／グルタミン酸残基を識別する二次元キラルHPLC-MS/MSアミノ酸分析法開発

    田川茂奈, 石井千晴, 秋田健行, 三田真史, 植田 正, 浜瀬健司

    日本薬学会第139年会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：千葉   Country：Japan  

  • ロイシン構造異性体α-キラルアミノ酸を対象とするオンライン二次元HPLC一斉分析法の開発と哺乳類体液試料における含量解析

    酒井健多, 秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィー科学会議  2018.11 

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    Event date： 2018.11

    Language：Japanese  

    Venue：豊橋   Country：Japan  

  • 二次元キラルHPLC-MS/MSを用いる分岐鎖D-アミノ酸残基網羅的精密分析法開発と各種タンパク質中における含量解析

    上村将平，石井千晴，三田真史，秋田健行，植田　正，浜瀬健司

    第29回クロマトグラフィー科学会議  2018.11 

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    Event date： 2018.11

    Language：Japanese  

    Venue：豊橋   Country：Japan  

  • トリプトファン鏡像異性体を対象とするNBD蛍光誘導体化三次元HPLC分析法開発と哺乳類内在性含量の解析

    吉田あすみ，二井屋田美樹，秋田健行，三田真史，浜瀬健司

    第29回クロマトグラフィー科学会議  2018.11 

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    Event date： 2018.11

    Language：Japanese  

    Venue：豊橋   Country：Japan  

  • ホモシステイン－システイン混合ジスルフィドの二次元キラルHPLC分析法開発とマウス尿中含量の解析

    岩下裕美，秋田健行，植田　正，浜瀬健司

    第29回クロマトグラフィー科学会議  2018.11 

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    Event date： 2018.11

    Language：Japanese  

    Venue：豊橋   Country：Japan  

  • Development of a three-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in human urine

    Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE

    2018.11 

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    Event date： 2018.11

    Language：English  

    Country：Japan  

  • キラルアミノ酸の多次元HPLC分析を指向した親水性アミノ酸含有新規Pirkle型固定相の開発

    吉岡夏輝,植木健治，秋田健行，三田真史，浜瀬健司

    第36回九州分析化学若手の会夏季セミナー  2018.7 

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    Event date： 2018.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • Ile立体異性体を含む疎水性アミノ酸の三次元HPLCキラル識別分析

    田中優光，酒井健多，秋田健行，三田真史，浜瀬健司

    第36回九州分析化学若手の会夏季セミナー  2018.7 

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    Event date： 2018.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • Selective screening of free D-amino acids in the physiological fluids and D-form residues in the proteins using an automated two-dimensional HPLC-MS/MS system International conference

    Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE

    2018 Sino-Japanese Joint Symposium on Separation Sciences  2018.7 

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    Event date： 2018.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：China  

  • Development of a three-dimentional HPLC system and application to the chiral amino acid analysis in the plasma of patients with kidney difunction International conference

    Aogu Furusho, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE

    2018 Sino-Japanese Joint Symposium on Separation Sciences  2018.7 

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    Event date： 2018.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：China  

  • 臨床試料におけるキラルアミノ酸高精度分析を可能とする選択的三次元HPLC法の開発

    古庄　仰，古賀鈴依子，秋田健行，三田真史，井手友美，木村友則，浜瀬健司

    第25回クロマトグラフィーシンポジウム  2018.6 

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    Event date： 2018.6 - 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：弘前   Country：Japan  

  • オンライン二次元HPLC-MS/MSシステムを用いるヒト臨床試料中遊離キラルアミノ酸の含量解析

    石井千晴，秋田健行，三田真史，井手友美，浜瀬健司

    第25回クロマトグラフィーシンポジウム  2018.6 

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    Event date： 2018.6 - 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：弘前   Country：Japan  

  • 親水性アミノ酸を有する新規Pirkle型キラル固定相の開発とNBD-アミノ酸の分離挙動解析

    吉岡夏輝,植木健治,秋田健行,三田真史,浜瀬健司

    日本薬学会第138年会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢   Country：Japan  

  • 多次元キラルHPLCを用いる疎水性アミノ酸精密分析法の開発

    田中優光，酒井健多，秋田健行，三田真史，浜瀬健司

    日本薬学会第138年会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢   Country：Japan  

  • 含硫アミノ酸光学異性体の多次元HPLC分析法開発とヒト血漿および尿における含量解析

    佐藤根詩織，岩下裕美，秋田健行，三田真史，井手友美，浜瀬健司

    日本薬学会第138年会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢   Country：Japan  

  • 新規蛍光誘導体化試薬NBD-COOSuを用いる親水性アミノ酸の二次元キラルHPLC分析法開発

    二井屋田美樹，吉田あすみ，秋田健行，三田真史，浜瀬健司

    日本薬学会第138年会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢   Country：Japan  

  • 二次元キラルHPLC-MS/MSを用いるタンパク質中の微量アスパラギン/アスパラギン酸残基識別分析法開発

    筒井　佑紀、石井　千晴、石郷　翔人、根岸　栄一、三田　真史、秋田　健行、植田　正、浜瀬　健司

    第28回クロマトグラフィー科学会議  2017.11 

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    Event date： 2017.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • 高分解能多次元HPLCを利用する親水性アミノ酸鏡像異性体の分析

    高橋　美帆、古庄　仰、三田　真史、秋田　健行、井手　友美、浜瀬　健司

    第28回　クロマトグラフィー科学会議  2017.11 

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    Event date： 2017.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • キラルアミノ酸の高選択的二次元HPLC-MS分析法開発と哺乳類体内D-アミノ酸の由来および疾患に伴う含量変化解析

    小川　亜都美、三次　百合香、木村　友則、三田　真史、秋田　健行、猪阪　善隆、浜瀬　健司

    第28回　クロマトグラフィー科学会議  2017.11 

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    Event date： 2017.11

    Language：Japanese  

    Venue：京都   Country：Japan  

  • ロイシン構造異性体の二次元キラルHPLC一斉分析法開発とD-アミノ酸酸化酵素欠損に伴う尿中含量変化の解析

    酒井健多、植木健治、古賀鈴依子、三次百合香、秋田健行、三田真史、金野柳一、浜瀬健司

    第30回バイオメディカル分析科学シンポジウム  2017.8 

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    Event date： 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • カラム内径比を制御した新規高感度型二次元HPLCの開発・評価と哺乳類組織中キラルアミノ酸分析への適用

    古庄　仰、古賀　鈴依子、秋田　健行、三次　百合香、三田　真史、浜瀬　健司

    第30回　バイオメディカル分析科学シンポジウム  2017.8 

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    Event date： 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京大学（東京）   Country：Japan  

  • カラム内径比を制御した新規高感度型二次元キラルHPLC分析装置の開発と脳内D-アミノ酸含量の解析

    古庄　仰, 古賀　鈴依子, 秋田　健行, 三次　百合香, 三田　真史, 濵瀬　健司

    第３５回九州分析化学若手の会　夏季セミナー  2017.7 

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    Event date： 2017.7

    Language：Japanese  

    Venue：朝倉   Country：Japan  

  • ロイシン構造異性体のα‐キラルアミノ酸を対象とした二次元HPLC一斉分析法の開発とヒト尿中含量の解析

    酒井健多、植木健治、古賀鈴依子、秋田健行、三次百合香、三田真史、井手友美、浜瀬健司

    第３５回九州分析化学若手の会　夏季セミナー  2017.7 

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    Event date： 2017.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：朝倉   Country：Japan  

  • Characterization of NBD-Amino Acids with Low Fluorescence Intensities and Application to Enantioselective HPLC Analysis

    Bing Zhao, Takeyuki Akita, Aogu Furusho, Masashi Mita, Kenji Hamase

    2017.7 

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    Event date： 2017.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • CHIRAL AMINO ACID METABOLOMICS USING MULTI-DIMENSIONAL HPLC International conference

    Kenji HAMASE, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Hiroshi Naraoka, Wolfgang LINDNER

    XVII International Symposium on Luminescence Spectrometry  2016.11 

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    Event date： 2016.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Taiwan, Province of China  

  • 二つのラジカル中心を持つチエノチオフェン環化合物の合成と磁気的性質

    秋田健行, 真崎康博, 小林啓二

    基礎有機化学連合討論会予稿集  1992.10 

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    Language：Japanese  

    Country：Japan  

  • 二つのラジカル中心を持つチエノチオフェン環化合物の磁気的性質

    秋田健行, 真崎康博, 阿波賀邦夫, 小林啓二

    日本化学会講演予稿集  1993.3 

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    Language：Japanese  

    Country：Japan  

  • 光照射による結晶中での安定三重項ラジカル対の生成

    真崎康博, 秋田健行, 小林啓二

    構造有機化学討論会講演予稿集  1993.9 

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    Language：Japanese  

    Country：Japan  

  • NO...Sコンタクトを通したニトロキシドラジカルのスピン相互作用

    秋田健行, 真崎康博, 小林啓二, 古賀登, 岩村秀

    構造有機化学討論会講演予稿集  1993.9 

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    Language：Japanese  

    Country：Japan  

  • ニトロキシドラジカルとホウ素化合物による錯形成と磁性

    秋田健行, 真崎康博, 小林啓二

    基礎有機化学連合討論会予稿集  1994.9 

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    Language：Japanese  

    Country：Japan  

  • チオフェン縮環体をスピンカップラーとするビラジカルのスピン伝達

    秋田健行, 真崎康博, 小林啓二, 丑田公規

    分子構造総合討論会講演要旨集  1994.9 

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    Language：Japanese  

    Country：Japan  

  • ニトロニルニトロキシド基をもつフェニルホウ酸誘導体の磁気的性質

    秋田健行, 真崎康博, 小林啓二

    日本化学会講演予稿集  1996.3 

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    Language：Japanese  

    Country：Japan  

  • 光応答型超高スピンデンドリマーの構築

    秋田健行，古賀登

    日本化学会第８３春季年会  2003.3 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • ２つのニトロキシドラジカルをもつジフェニルアセチレンの合成と磁性

    田尻幸浩，秋田健行，古賀登

    日本化学会第８３春季年会  2003.3 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 光応答型高スピンデンドリマーの構築とその磁性

    秋田健行，古賀登

    第40回化学関連支部合同九州大会  2003.7 

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    Presentation type：Oral presentation (general)  

    Venue：北九州   Country：Japan  

  • Effect of Peripheral Groups in Super-high Spin Dendritic Polycarbene International conference

    Takeyuki Akita and Noboru Koga

    Kyushu International Symposium on Physical Organic Chemistry (KISPOC-X)  2003.9 

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    Presentation type：Oral presentation (general)  

    Country：Japan  

  • 光応答性超高スピンデンドリマーにおける表面置換基の効果

    秋田健行，古賀登

    第３３回構造有機化学討論会  2003.10 

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    Presentation type：Oral presentation (general)  

    Venue：富山   Country：Japan  

  • 光応答型高スピンデンドリマーの凝集フィルム及び剛体溶液中での磁気的性質

    秋田健行，古賀登

    日本化学会第８４春季年会  2004.3 

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    Presentation type：Oral presentation (general)  

    Venue：西宮   Country：Japan  

  • 嵩高い表面置換基を持つ光応答型高スピンデンドリマーの磁気的性質

    秋田健行，古賀登

    第１７回基礎有機化学連合討論会  2004.9 

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    Presentation type：Oral presentation (general)  

    Venue：仙台   Country：Japan  

  • Magnetic Properties of Dendritic Polycarbenes Substituted by Bulky Peripheral Groups International conference

    Takeyuki Akita and Noboru Koga

    The 9th International Conference on Molecular-Based Magnets  2004.10 

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    Presentation type：Oral presentation (general)  

    Country：Japan  

  • ジクワットユニットを有するトラキセン誘導体からの トリラジカル種の発生

    佐藤寛泰・真崎康博・松沢英世・岩橋槇夫・秋田健行・古賀　登・山本　学

    日本化学会第８５春期年会  2005.3 

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    Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Japan  

  • 嵩高い表面置換基を導入したポリジアゾデンドリマーの 凝集フィルム及び剛体溶液中での光照射後の磁気的性質

    秋田健行、古賀登

    日本化学会第８５春期年会  2005.3 

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    Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Japan  

  • ジクワットユニットを有するトラキセン誘導体の磁気的性質

    佐藤寛泰・真崎康博・松沢英世・岩橋槇夫・山本学・秋田健行・古賀　登

    第３５回　構造有機化学討論会  2005.9 

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    Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • 種々の表面置換基を導入したデンドリマー型超高スピン 有機化合物の合成と物性 Invited

    秋田健行、古賀登

    第３５回　構造有機化学討論会  2005.9 

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    Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • Magnetic properties of amorphous neat films made of dendritic polycarbenes International conference

    Takeyuki Akita and Noboru Koga

    Pacifichem 2005  2005.12 

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    Presentation type：Oral presentation (general)  

    Country：United States  

  • ジフェニルアセチレンで連結されたジアゾ基を持つ樹状ポリマーの合成と光照射後の磁気的性質

    秋田健行、古賀登

    第１８回　基礎有機化学連合討論会  2006.10 

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    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Pirkle型カラムにおける分析温度変更とNBD-アミノ酸鏡像異性体の分離挙動

    小園拓歩，小柳出麻衣，石井千晴，三田真史，秋田健行，浜瀬健司

    九州分析化学若手の会 第36回若手研究講演会および第41回夏季セミナー 

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    Language：Japanese   Presentation type：Poster presentation  

  • 高性能Pirkle型キラル固定相を用いるグリシン含有ジペプチドの光学分割

    横谷 昌祐, 秋田 健行, 山崎 千夏, 石井 千晴, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 直鎖脂肪族アミノ酸を有するPirkle型固定相の開発とNBD-アミノ酸鏡像異性体の分離

    中川 雄太, 梶原 雅貴, 秋田 健行, 石井 千晴, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 塩基性アミノ酸を対象とする高選択的二次元キラルHPLC分析法の開発

    長谷川 美優, 守永 麟, 石井 千晴, 秋田 健行, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • 各種Pirkle型キラル固定相におけるロイシン連鎖異性体の分離挙動解析

    山部 真弓, 石井 千晴, 秋田 健行, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • 光リアクター搭載二次元HPLCを利用するNBD-Trp鏡像異性体の高感度分析法開発

    山下 愛絵, 石井 千晴, 古庄 仰, 秋田 健行, 根岸 栄一, 井本 啓史, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • 二次元キラルHPLCを用いるアラニン、アスパラギン酸、セリン、乳酸および3-ヒドロキシ酪酸の同時分析法開発

    坂元 瞭太, 謝 金玲, 山元 一輝, 石井 千晴, 秋田 健行, 三田 真史, 井手 友美, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • 二次元LC-MS/MSを用いるシステイン残基のキラル識別微量分析法開発とタンパク質・ペプチドへの適用

    末吉 里絵, 石井 千晴, 秋田 健行, 三田 真史, 植田 正, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • ヒト血液および尿中におけるヒドロキシアミノ酸鏡像異性体の高分離能二次元HPLC分析法開発

    小柳出 麻衣, 古庄 仰, 石井 千晴, 秋田 健行, 三田 真史, 井手 友美, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • セリンおよびアスパラギン酸の高選択的三次元キラルHPLC分析法開発とヒト血中含量解析

    梶原 雅貴, 秋田 健行, 石井 千晴, 三田 真史, 井手 友美, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

  • キラルアミノ酸の高選択的三次元HPLC分析を目的とする新規ミックスモードカラムの開発

    永田 優凜, 古庄 仰, 石井 千晴, 秋田 健行, 三田 真史, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • Asn/AspおよびGln/Glu残基を対象とする二次元キラルLC-MS/MS微量分析法開発と実試料における含量解析

    竹島 華菜子, 石井 千晴, 秋田 健行, 浜本 洋, 三田 真史, 関水 和久, 植田 正, 浜瀬 健司

    日本薬学会年会要旨集  2022.3  (公社)日本薬学会

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    Language：Japanese  

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MISC

  • Three/four-dimensional HPLC analysis of chiral amino acids and related compounds in the biological, food and extraterrestrial samples

    浜瀬健司, 石井千晴, 秋田健行, 三田真史, 井手友美, 木村友則, 奈良岡浩

    バイオメディカル分析科学シンポジウム講演要旨集   35th   2023   （ ISSN:1347-2364 ）

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  • Two-dimensional LC-MS/MS Determination of D-Amino Acids in Human Plasma and the Screening of Biomarkers for Kidney Function Reviewed

    石井千晴, 秋田健行, 三田真史, 井手友美, 木村友則, 浜瀬健司

    バイオメディカル分析科学シンポジウム講演要旨集   35th   2023   （ ISSN:1347-2364 ）

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    Language：Japanese  

    J-GLOBAL

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本化学会

  • クロマトグラフィー科学会

  • The Pharmaceutical Society of Japan

Academic Activities

  • 薬学教育放射薬学教科担当教員会議　次期世話人

    薬学教育放射薬学教科担当教員会議  （ 横浜 ） 2024.3

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    Type：Competition, symposium, etc. 

  • 第34回クロマトグラフィー科学会議　運営

    Role(s)： Planning, management, etc.

    第34回クロマトグラフィー科学会議  （ 福岡 ） 2023.10

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    Type：Competition, symposium, etc. 

  • 薬学教育放射薬学教科担当教員会議

    薬学教育放射薬学教科担当教員会議  （ 札幌 ） 2023.3

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • 第２９回クロマトグラフィーシンポジウム　実行委員

    Role(s)： Planning, management, etc.

    第２９回クロマトグラフィーシンポジウム  （ 石垣市 ） 2022.6

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    Type：Competition, symposium, etc. 

  • 薬学教育放射薬学教科担当教員会議

    薬学教育放射薬学教科担当教員会議  （ オンライン ） 2022.3

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    Type：Competition, symposium, etc. 

  • クロマトグラフィー次世代技術セミナー2021　学会HP作成

    Role(s)： Planning, management, etc.

    クロマトグラフィー次世代技術セミナー2021  （ 石垣市 ） 2021.10

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    Type：Competition, symposium, etc. 

  • 31st International Symposium on Pharmaceutical and Biomedical Analysis (PBA2021)　学会HP作成および学会会場運営 International contribution

    Role(s)： Planning, management, etc.

    （ 京都市 ） 2021.8 - 2021.9

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • the 4th International Conference of D-Amino Acid Research (IDAR2019)　実行委員 International contribution

    Role(s)： Planning, management, etc.

    2019.9

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    Type：Competition, symposium, etc. 

    Number of participants：300

  • 実行委員（会計）

    第３１回バイオメディカル分析科学シンポジウム（BMAS2018)  （ 九州大学（福岡市） ） 2018.8

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    Type：Competition, symposium, etc. 

  • 第18回基礎有機化学連合討論会　実行委員会委員

    第18回基礎有機化学連合討論会  （ 九州産業大学，福岡 ） 2006.10 - Present

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    Type：Competition, symposium, etc. 

    Number of participants：300

  • 座長（Chairmanship） International contribution

    （ 福岡 ） 2003.4 - Present

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本化学会第８３春期年会  （ 東京 ） 2003.3 - Present

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    Type：Competition, symposium, etc. 

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Research Projects

  • キラルアミノ酸分析ハイスループットカラム及びシステム開発

    2022.9 - 2023.3

    共同研究

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    Authorship：Coinvestigator(s)  Grant type：Other funds from industry-academia collaboration

  • キラル・アキラル複合型固定相のテイラーメイドと二次元LCを用いる医療シーズ探索

    2022.4 - 2025.3

    　 More details

    Authorship：Principal investigator 

  • 血液／尿中キラルアミノ酸の網羅的定量を基盤とする腎不全の早期低侵襲診断鑑別法開発

    2022.4 - 2025.3

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    Authorship：Coinvestigator(s) 

  • 血液／尿中キラルアミノ酸の網羅的定量を基盤とする腎不全の早期低侵襲診断鑑別法開発

    Grant number：23K24015  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    濱瀬 健司, 秋田 健行, 石井 千晴, 猪阪 善隆, 木村 友則, 井手 友美

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    血中・尿中キラルアミノ酸の網羅的定量により、非侵襲・低侵襲での腎不全の早期診断、原因疾患鑑別マーカーを探索する。腎不全は慢性型の患者が多く、早期診断が予防と治療に直結する。応募者は予備試験で、キラルを識別した正確なアミノ酸定量により腎不全の鋭敏なマーカーが発見でき、血中・尿中の含量比較により原因疾患の鑑別が可能であるという結果を得た。そこで本研究では多次元HPLCにより網羅的定量法を開発し、多数の臨床検体を用いた含量解析を行うと共に動物モデルによる機序解析を行う。本研究の達成は侵襲性の低い血液・尿分析による腎不全の早期診断、原因疾患鑑別を可能とし、人々の健康寿命延長に貢献する。

    CiNii Research

  • キラル・アキラル複合型固定相のテイラーメイドと二次元LCを用いる医療シーズ探索

    Grant number：22K06547  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    秋田 健行, 濱瀬 健司, 石井 千晴

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    Authorship：Principal investigator  Grant type：Scientific research funding

    微量鏡像異性体の生体中での変動や機能の解析を加速し、医薬品やバイオマーカーなどの医療におけるシーズ探索を飛躍的に推進させることを実現するため、（１）様々な表面置換基量を細かく制御した、再現的なキラル・アキラル複合型ＬＣ固定相合成法の確立、および（２）最適な固定相組成の合理的類推法の確立を行う。また（３）ヒト尿試料や血漿試料、ヒト疾患モデル動物試料などをマトリックスとして、最適化されたテイラーメイド複合型固定相を用いる微量鏡像異性体分析法を開発し、医療シーズ探索を行う。

    CiNii Research

  • 血液／尿中キラルアミノ酸の網羅的定量を基盤とする腎不全の早期低侵襲診断鑑別法開発

    Grant number：22H02752  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • キラルメタボロミクスの飛躍的推進を可能とする二次元LC分離場ライブラリの構築

    2019.4 - 2022.3

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    Authorship：Principal investigator 

  • 定量キラルメタボロミクスを実現する三次元LC分析基盤開発と腎・心不全の早期診断

    2019.4 - 2021.3

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    Authorship：Coinvestigator(s) 

  • 定量キラルメタボロミクスを実現する三次元LC分析基盤開発と腎・心不全の早期診断

    Grant number：19H03359  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    濱瀬 健司, 猪阪 善隆, 木村 友則, 秋田 健行, 井手 友美

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    定量キラルメタボロミクス実現のため、世界に先駆けて三次元LC分析基盤を開発し、腎・心不全の診断マーカーを探索する。これらは生活習慣を含む様々な要因で発症し、日本でも1000万人以上が罹患している。慢性化することが多く、早期診断が予防と治療に直結する。応募者は予試験を通しキラル識別により新規マーカーが発見でき、早期診断には微量キラル化合物を正確に定量する三次元LCの構築が有用となる確信を得た。本研究では定量三次元LC分析法を開発し、疾患モデル動物および臨床検体を用いた含量解析を行う。本研究の達成は侵襲性の低い血液・尿分析による腎・心不全の早期診断、鑑別を可能とし、人々の健康寿命延長に貢献する。

    CiNii Research

  • キラルメタボロミクスの飛躍的推進を可能とする二次元LC分離場ライブラリの構築

    Grant number：19K07027  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    秋田 健行, 濱瀬 健司

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    Authorship：Principal investigator  Grant type：Scientific research funding

    生体内の様々なキラル低分子について、未だ不可能である鏡像異性体を区別した網羅的定量キラルメタボロミクスの飛躍的推進を可能にする分離場として、二次元LC分離場ライブラリの開発を行う。これにより様々な微量鏡像異性体の生体中における存在や分布、機能の解明を推進し、医療における新たなシーズ探索を加速する。分析装置は当研究室で開発した二次元キラルHPLCシステムを基盤とし、多様な不斉認識部位を持つHPLC用固定相を合成し、キラル分離場ライブラリを構成する。さらに、ヒト尿試料や血漿試料、ヒト疾患モデルとなるマウスやラット試料中の微量異性体の網羅的分析法を開発する。

    CiNii Research

  • 超常磁性酸化鉄ナノパーティクルを用いた反応の磁場制御

    2009.4 - 2012.3

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    Authorship：Principal investigator 

  • 超常磁性酸化物ナノパーティクルを用いた反応の磁場制御

    Grant number：21651055  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 超常磁性鉄酸化物ナノパーティクルを用いた反応の磁場制御

    Grant number：21651055  2009 - 2011

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 単分子磁石を構成単位とした自己集合体の磁性研究

    Grant number：17350070  2005 - 2006

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 不明

    2003 - 2006

    科学研究費助成事業  特定領域研究(A)特定領域研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 分子磁性研究に基づいて設計された多重項スピン種のMRI造影剤への展開

    Grant number：15087205  2003 - 2006

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 不明

    2002 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(A)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 剛体溶媒中での光応答型単分子磁石構築の研究

    Grant number：14204071  2002 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 水素結合の多点認識による有機高スピン超分子の構築

    Grant number：12740384  2000 - 2001

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 水素結合の多点認識による有機高スピン超分子の構築

    2000 - 2001

    科学研究費助成事業  奨励研究(A)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 光照射による高スピンネットワークの構築

    Grant number：11133248  1999

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 光水素移動反応による有機磁性の可逆的スイッチ

    1998 - 1999

    科学研究費助成事業  奨励研究(A)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 光水素移動反応による有機磁性の可逆的スイッチ

    Grant number：10740327  1998 - 1999

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 光照射による高スピンネットワークの構築

    Grant number：10146239  1998

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

  • 不明

    1997 - 1999

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 光応答型磁気カップラーを用いた多次元スピンネットワークの構築とその磁性

    Grant number：09440242  1997 - 1999

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Grant type：Scientific research funding

▼display all

Educational Activities

  • Practice Experiments 1 in Basic Pharmaceutics, Presentation Practice I in Medicinal Chemistry, Presentation Practice II in Medicinal Chemistry

Class subject

  • 物理薬学研究

    2024.12 - 2025.2   Winter quarter

  • 応用機器分析学

    2024.12 - 2025.2   Winter quarter

  • 放射化学

    2024.10 - 2024.12   Fall quarter

  • 物理化学演習

    2024.10 - 2024.12   Fall quarter

  • 物理薬学Ⅲ

    2024.6 - 2024.8   Summer quarter

  • 物理薬学演習Ⅱ

    2024.4 - 2024.9   First semester

  • 物理薬学演習Ⅰ

    2024.4 - 2024.9   First semester

  • 連携大学院合宿研修

    2024.4 - 2024.9   First semester

  • 物理化学的測定法

    2024.4 - 2024.6   Spring quarter

  • 薬学基礎実習Ⅱ

    2024.4 - 2024.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 臨床検査学Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 物理薬学研究

    2023.12 - 2024.2   Winter quarter

  • 応用機器分析学

    2023.12 - 2024.2   Winter quarter

  • 放射化学

    2023.10 - 2023.12   Fall quarter

  • 物理化学演習

    2023.10 - 2023.12   Fall quarter

  • 物理薬学Ⅲ

    2023.6 - 2023.8   Summer quarter

  • 物理薬学演習Ⅱ

    2023.4 - 2023.9   First semester

  • 物理化学的測定法

    2023.4 - 2023.9   First semester

  • 連携大学院合宿研修

    2023.4 - 2023.9   First semester

  • 物理薬学演習Ⅰ

    2023.4 - 2023.9   First semester

  • 臨床検査学Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 薬学基礎実習Ⅱ

    2023.4 - 2023.6   Spring quarter

  • 応用機器分析学

    2022.12 - 2023.2   Winter quarter

  • 放射化学

    2022.12 - 2023.2   Winter quarter

  • 物理薬学研究

    2022.12 - 2023.2   Winter quarter

  • 放射化学

    2022.12 - 2023.2   Winter quarter

  • 物理薬学研究

    2022.10 - 2023.3   Second semester

  • 課題協学科目

    2022.10 - 2023.3   Second semester

  • 課題協学科目

    2022.10 - 2023.3   Second semester

  • 物理薬学演習Ⅱ

    2022.10 - 2023.3   Second semester

  • 物理薬学演習Ⅰ

    2022.10 - 2023.3   Second semester

  • 物理化学演習

    2022.10 - 2022.12   Fall quarter

  • 物理薬学Ⅲ

    2022.6 - 2022.8   Summer quarter

  • 物理化学的測定法

    2022.4 - 2022.9   First semester

  • 連携大学院合宿研修

    2022.4 - 2022.9   First semester

  • 薬学基礎実習Ⅱ

    2022.4 - 2022.6   Spring quarter

  • 臨床検査学Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 放射化学

    2021.12 - 2022.2   Winter quarter

  • 応用機器分析学

    2021.12 - 2022.2   Winter quarter

  • 物理薬学演習Ⅱ

    2021.10 - 2022.3   Second semester

  • 物理薬学研究

    2021.10 - 2022.3   Second semester

  • 物理薬学演習Ⅰ

    2021.10 - 2022.3   Second semester

  • 物理化学演習

    2021.10 - 2021.12   Fall quarter

  • 放射化学

    2021.6 - 2021.8   Summer quarter

  • 物理薬学Ⅲ

    2021.6 - 2021.8   Summer quarter

  • 薬学基礎実習Ⅱ

    2021.6 - 2021.8   Summer quarter

  • 連携大学院合宿研修

    2021.4 - 2021.9   First semester

  • 物理化学的測定法

    2021.4 - 2021.9   First semester

  • 応用機器分析学

    2021.4 - 2021.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2021.4 - 2021.6   Spring quarter

  • 物理薬学演習Ⅰ

    2020.12 - 2021.2   Winter quarter

  • 物理薬学研究

    2020.12 - 2021.2   Winter quarter

  • 物理薬学演習Ⅱ

    2020.10 - 2020.12   Fall quarter

  • 物理化学演習

    2020.10 - 2020.12   Fall quarter

  • 物理化学的測定法

    2020.10 - 2020.12   Fall quarter

  • 臨床検査学Ⅰ

    2020.10 - 2020.12   Fall quarter

  • 放射化学

    2020.6 - 2020.8   Summer quarter

  • 薬学基礎実習Ⅱ

    2020.6 - 2020.8   Summer quarter

  • 物理薬学Ⅲ

    2020.6 - 2020.8   Summer quarter

  • 応用機器分析学

    2020.4 - 2020.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2020.4 - 2020.6   Spring quarter

  • 物理薬学研究

    2019.12 - 2020.2   Winter quarter

  • 臨床検査学Ⅰ

    2019.10 - 2019.12   Fall quarter

  • 物理化学演習

    2019.10 - 2019.12   Fall quarter

  • 放射化学

    2019.6 - 2019.8   Summer quarter

  • 物理薬学Ⅲ

    2019.6 - 2019.8   Summer quarter

  • 物理薬学演習Ⅱ

    2019.6 - 2019.8   Summer quarter

  • 物理薬学演習Ⅰ

    2019.6 - 2019.8   Summer quarter

  • 薬学基礎実習Ⅱ

    2019.6 - 2019.8   Summer quarter

  • 学術英語3・科学英語

    2019.4 - 2019.9   First semester

  • 連携大学院合宿研修

    2019.4 - 2019.9   First semester

  • 薬学基礎実習Ⅰ

    2019.4 - 2019.6   Spring quarter

  • 物理化学的測定法

    2019.4 - 2019.6   Spring quarter

  • 応用機器分析学

    2019.4 - 2019.6   Spring quarter

  • 学術英語3・科学英語

    2018.10 - 2019.3   Second semester

  • 物理化学演習

    2018.10 - 2018.12   Fall quarter

  • 臨床検査学Ⅰ

    2018.10 - 2018.12   Fall quarter

  • 物理薬学Ⅲ

    2018.10 - 2018.12   Fall quarter

  • 放射化学

    2018.6 - 2018.8   Summer quarter

  • 物理薬学演習Ⅱ

    2018.6 - 2018.8   Summer quarter

  • 薬学基礎実習Ⅱ

    2018.6 - 2018.8   Summer quarter

  • 物理薬学演習Ⅰ

    2018.6 - 2018.8   Summer quarter

  • 学術英語3・科学英語

    2018.4 - 2018.9   First semester

  • 連携大学院合宿研修

    2018.4 - 2018.9   First semester

  • 薬学基礎実習Ⅰ

    2018.4 - 2018.6   Spring quarter

  • 応用機器分析学

    2018.4 - 2018.6   Spring quarter

  • 物理化学的測定法

    2018.4 - 2018.6   Spring quarter

  • 物理化学演習

    2017.10 - 2017.12   Fall quarter

  • 学術英語3・科学英語

    2017.10 - 2017.12   Fall quarter

  • 放射化学

    2017.6 - 2017.8   Summer quarter

  • 物理薬学演習Ⅰ

    2017.6 - 2017.8   Summer quarter

  • 薬学基礎実習Ⅱ

    2017.6 - 2017.8   Summer quarter

  • 物理薬学演習Ⅱ

    2017.6 - 2017.8   Summer quarter

  • 物理化学的測定法

    2017.4 - 2017.6   Spring quarter

  • 薬学基礎実習Ⅰ

    2017.4 - 2017.6   Spring quarter

  • 物理化学演習

    2016.10 - 2017.3   Second semester

  • 学術英語3・科学英語

    2016.10 - 2017.3   Second semester

  • 薬学基礎実習Ⅰ

    2016.4 - 2016.9   First semester

  • 物理薬学演習Ⅱ

    2016.4 - 2016.9   First semester

  • 物理薬学演習Ⅰ

    2016.4 - 2016.9   First semester

  • 医薬化学演習Ⅱ

    2016.4 - 2016.9   First semester

  • 医薬化学演習Ⅰ

    2016.4 - 2016.9   First semester

  • 薬学基礎実習Ⅱ

    2016.4 - 2016.9   First semester

  • 有機化学系教育指導実習

    2015.4 - 2015.9   First semester

  • 薬学基礎実習Ⅰ

    2015.4 - 2015.9   First semester

  • 医薬化学演習Ⅰ

    2015.4 - 2015.9   First semester

  • 医薬化学演習Ⅱ

    2015.4 - 2015.9   First semester

  • 薬学基礎実習Ⅰ

    2014.4 - 2014.9   First semester

  • 有機化学系教育指導実習

    2014.4 - 2014.9   First semester

  • 医薬化学演習Ⅱ

    2014.4 - 2014.9   First semester

  • 医薬化学演習Ⅰ

    2014.4 - 2014.9   First semester

  • 薬学基礎実習Ⅰ

    2013.4 - 2013.9   First semester

  • 有機化学系教育指導実習

    2013.4 - 2013.9   First semester

  • 医薬化学演習Ⅱ

    2013.4 - 2013.9   First semester

  • 医薬化学演習Ⅰ

    2013.4 - 2013.9   First semester

  • 薬学基礎実習Ⅰ

    2012.4 - 2012.9   First semester

  • 有機化学系教育指導実習

    2012.4 - 2012.9   First semester

  • 医薬化学演習Ⅱ

    2012.4 - 2012.9   First semester

  • 医薬化学演習Ⅰ

    2012.4 - 2012.9   First semester

  • 薬学基礎実習Ⅰ

    2011.4 - 2011.9   First semester

  • 有機化学系教育指導実習

    2011.4 - 2011.9   First semester

  • 医薬化学演習Ⅱ

    2011.4 - 2011.9   First semester

  • 医薬化学演習Ⅰ

    2011.4 - 2011.9   First semester

  • 薬学基礎実習Ⅰ

    2010.4 - 2010.9   First semester

  • 有機化学系教育指導実習

    2010.4 - 2010.9   First semester

  • 医薬化学演習Ⅱ

    2010.4 - 2010.9   First semester

  • 医薬化学演習Ⅰ

    2010.4 - 2010.9   First semester

  • 薬学基礎実習I

    2009.4 - 2009.9   First semester

  • 有機化学系教育指導実習

    2009.4 - 2009.9   First semester

  • 医薬化学総論

    2009.4 - 2009.9   First semester

  • 創薬化学実習

    2008.4 - 2008.9   First semester

  • 医薬化学総論

    2008.4 - 2008.9   First semester

  • 医薬化学総論

    2007.4 - 2007.9   First semester

  • 創薬化学実習

    2006.10 - 2007.3   Second semester

  • 医薬化学総論

    2006.4 - 2006.9   First semester

  • 創薬化学実習

    2005.10 - 2006.3   Second semester

  • 医薬化学総論

    2005.4 - 2005.9   First semester

  • 創薬化学実習

    2004.10 - 2005.3   Second semester

  • 基礎薬学セミナー

    2004.4 - 2004.9   First semester

  • 医薬化学総論

    2004.4 - 2004.9   First semester

  • 物理薬学研究

    2024.12 - 2025.2   Winter quarter

  • 放射化学

    2024.10 - 2024.12   Fall quarter

  • 物理薬学演習Ⅱ

    2024.4 - 2024.9   First semester

  • 物理薬学演習Ⅰ

    2024.4 - 2024.9   First semester

  • 物理化学的測定法

    2024.4 - 2024.6   Spring quarter

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FD Participation

  • 2024.9   Role：Participation   Title：馬出地区4部局合同男女共同参画FD/ 病院きらめきプロジェクト講演会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2024.9   Role：Participation   Title：全学FD「M2B講習会」（9/13～オンデマンド配信）

    Organizer：University-wide

  • 2024.9   Role：Participation   Title：【全学FD】薬物依存対策研修会

    Organizer：University-wide

  • 2024.7   Role：Participation   Title：第5回創薬産学官連携セミナー（新モダリティ）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.11   Role：Participation   Title：第２回部局FD講演会「機関間連携」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role：Participation   Title：令和５年度４部局合同男女共同参画ＦＤ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.3   Role：Participation   Title：全学FD:メンタルヘルス講演会

    Organizer：University-wide

  • 2023.3   Role：Participation   Title：全学FD「M2Bシステムの使い方」（3/9～オンデマンド）

    Organizer：University-wide

  • 2023.3   Role：Participation   Title：TF（ティーチング・フェロー）経験を通じて大学院生の教育能力を高める

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.11   Role：Participation   Title：第４回創薬産学官連携セミナー（アカデミア創薬）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.9   Role：Participation   Title：課題協学科目第二回FD

    Organizer：University-wide

  • 2022.6   Role：Participation   Title：課題協学科目第一回FD

    Organizer：University-wide

  • 2022.4   Role：Participation   Title：学生の多様性に対応した教育とは：障害学生への合理的配慮を中心に

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role：Participation   Title：新M2Bシステムの使い方　～新機能を中心に紹介します～（3/14）

    Organizer：University-wide

  • 2022.3   Role：Participation   Title：第3回創薬産学官連携セミナー（感染症研究拠点WG共催）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.2   Role：Participation   Title：令和３年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Role：Participation   Title：JST 次世代研究者挑戦的研究プログラム 説明会

    Organizer：University-wide

  • 2021.5   Role：Participation   Title：第2回創薬産学官連携セミナー

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.2   Role：Participation   Title：創薬産学官連携セミナー

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.10   Role：Participation   Title：令和２年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.10   Role：Participation   Title：令和元年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.9   Role：Participation   Title：外国人研究者・留学生受け入れ、貨物輸出と技術の提供に関して

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.11   Role：Participation   Title：「Scopusの論文データを用いた薬学研究院の研究力分析」および「BIツールを用いた研究力分析の紹介」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role：Participation   Title：平成３０年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role：Participation   Title：M2B/Moodleに関するFD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.2   Role：Participation   Title：総合的創薬ソリューションプロバイダーによる創薬研究支援の新たな形

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2017.10   Role：Participation   Title：「病院地区4部局合同男女共同参画FD」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2017.8   Role：Participation   Title：第3回若手薬学教育者のためのアドバンストワークショップ

  • 2017.3   Role：Participation   Title：第3回 薬学研究院FD（情報セキュリティ対策）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.10   Role：Participation   Title：馬出地区キャンパスFD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role：Participation   Title：外国人留学生の受入と管理（情報管理、輸出管理）について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.6   Role：Participation   Title：製薬業界の環境変 化を受けた今後のＭＲ活動とメディカルアフェアーズの確立について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.2   Role：Participation   Title：Education in Chemistry at Nanyang Technological University

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2012.3   Role：Participation   Title：学生のメンタルヘルスの現状と対応

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2010.4   Role：Participation   Title：薬局実務実習指導評価講習会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2008.12   Role：Participation   Title：OSCEトライアル練習会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：木曜1,2限

  • 2022  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Teaching Student Awards

  • Best Presentation Award

    Year and month of award：2024.8

    Classification of award-winning students：Postgraduate student   Name of award-winning student：岡部　理子

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：岡部　理子

  • ChemBioChem Best Poster Award

    Year and month of award：2024.8

    Classification of award-winning students：Postgraduate student   Name of award-winning student：小田　京香

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：小田　京香

  • 九州分析化学若手賞

    Year and month of award：2024.7

    Classification of award-winning students：Postgraduate student   Name of award-winning student：三ノ宮　悠介

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：三ノ宮　悠介

  • 九州分析化学若手賞

    Year and month of award：2024.7

    Classification of award-winning students：Postgraduate student   Name of award-winning student：道清　祐輝

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：道清　祐輝

  • 九州分析化学奨励賞

    Year and month of award：2024.7

    Classification of award-winning students：Doctoral student   Name of award-winning student：永田　優凜

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：永田　優凜

  • 優秀発表賞

    Year and month of award：2023.10

    Classification of award-winning students：Undergraduate student   Name of award-winning student：山下　愛絵

    　 More details

    Classification of the awarding organization：Undergraduate student   Awarding organization：山下　愛絵

  • 優秀発表賞

    Year and month of award：2023.7

    Classification of award-winning students：Postgraduate student   Name of award-winning student：山部　真弓

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：山部　真弓

  • 九州分析化学奨励賞

    Year and month of award：2023.7

    Classification of award-winning students：Doctoral student   Name of award-winning student：小柳出　麻衣

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：小柳出　麻衣

  • 優秀発表賞

    Year and month of award：2023.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：岡部　理子

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：岡部　理子

  • Chromatography Outstanding Student Paper Award 2023

    Year and month of award：2023.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：永田　優凜

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：永田　優凜

  • 優秀発表賞

    Year and month of award：2022.11

    Classification of award-winning students：Postgraduate student   Name of award-winning student：竹島華菜子

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：竹島華菜子

  • 優秀発表賞

    Year and month of award：2022.11

    Classification of award-winning students：Postgraduate student   Name of award-winning student：末吉　里絵

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：末吉　里絵

  • 優秀発表賞

    Year and month of award：2022.9

    Classification of award-winning students：Postgraduate student   Name of award-winning student：小柳出麻衣

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：小柳出麻衣

  • Chromatography Outstanding Student Paper Award 2022

    Year and month of award：2022.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：小柳出麻衣

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：小柳出麻衣

  • 日本薬学会第142年会

    Year and month of award：2022.4

    Classification of award-winning students：Postgraduate student   Name of award-winning student：末吉　里絵

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：末吉　里絵

  • 日本薬学会第142年会

    Year and month of award：2022.4

    Classification of award-winning students：Postgraduate student   Name of award-winning student：竹島　華菜子

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：竹島　華菜子

  • Chromatography Outstanding Student Paper Award 2022

    Year and month of award：2021.12

    Classification of award-winning students：Doctoral student   Name of award-winning student：古庄　仰

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：古庄　仰

  • Chromatography Outstanding Student Paper Award 2021

    Year and month of award：2021.10

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • Chromatography Outstanding Student Paper Award 2019

    Year and month of award：2020.11

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • 九州分析化学奨励賞

    Year and month of award：2020.11

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • 優秀発表賞

    Year and month of award：2020.11

    Classification of award-winning students：Undergraduate student   Name of award-winning student：田川　茂奈

    　 More details

    Classification of the awarding organization：Undergraduate student   Awarding organization：田川　茂奈

  • Chromatography Outstanding Student Paper Award 2019

    Year and month of award：2020.11

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井千晴

  • 優秀発表賞

    Year and month of award：2019.12

    Classification of award-winning students：Undergraduate student   Name of award-winning student：佐藤根詩織

    　 More details

    Classification of the awarding organization：Undergraduate student   Awarding organization：佐藤根詩織

  • Analytical Sciences Poster Award

    Year and month of award：2019.12

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • 九州大学女性優秀研究者賞

    Year and month of award：2019.10

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井　千晴

  • Best Poster Award

    Year and month of award：2019.9

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井　千晴

  • Best Presentation Award

    Year and month of award：2019.9

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • 九州分析化学奨励賞

    Year and month of award：2019.7

    Classification of award-winning students：Doctoral student   Name of award-winning student：古庄　仰

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：古庄　仰

  • 九州分析化学若手賞

    Year and month of award：2019.7

    Classification of award-winning students：Doctoral student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：謝　金玲

  • Best Poster Award

    Year and month of award：2019.6

    Classification of award-winning students：Doctoral student   Name of award-winning student：古庄　仰

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：古庄　仰

  • Poster Presentation Award

    Year and month of award：2019.3

    Classification of award-winning students：Doctoral student   Name of award-winning student：高橋　美帆

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：高橋　美帆

  • Oral Presentation Award

    Year and month of award：2019.3

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井　千晴

  • First Poster Prize

    Year and month of award：2018.9

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井　千晴

  • 九州分析化学奨励賞

    Year and month of award：2018.7

    Classification of award-winning students：Doctoral student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Doctoral student   Awarding organization：石井　千晴

  • Chromatography Outstanding Student Paper Award 2018

    Year and month of award：2018.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：古庄　仰

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：古庄　仰

  • Best Poster Award

    Year and month of award：2018.3

    Classification of award-winning students：Research student   Name of award-winning student：Siralak Laoratanapong

    　 More details

    Classification of the awarding organization：Research student   Awarding organization：Siralak Laoratanapong

  • 優秀発表賞

    Year and month of award：2017.11

    Classification of award-winning students：Undergraduate student   Name of award-winning student：筒井　佑紀

    　 More details

    Classification of the awarding organization：Undergraduate student   Awarding organization：筒井　佑紀

  • Best Poster Award

    Year and month of award：2017.11

    Classification of award-winning students：Postgraduate student   Name of award-winning student：酒井　健多

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：酒井　健多

  • 九州分析化学若手賞

    Year and month of award：2017.7

    Classification of award-winning students：Postgraduate student   Name of award-winning student：古庄　仰

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：古庄　仰

  • Chromatography Outstanding Student Paper Award 2017

    Year and month of award：2017.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：石井　千晴

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：石井　千晴

  • 優秀発表賞

    Year and month of award：2017.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：謝　金玲

    　 More details

    Classification of the awarding organization：Postgraduate student   Awarding organization：謝　金玲

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Other educational activity and Special note

  • 2023  Class Teacher 

  • 2022  Special Affairs 

  • 2021  Special Affairs 

  • 2019  Special Affairs 

  • 2019  Special Affairs 

  • 2018  Special Affairs 

  • 2018  Special Affairs 

  • 2017  Special Affairs 

▼display all

Outline of Social Contribution and International Cooperation activities

  • 企業との共同研究等の産学官連携活動を積極的に推進することにより、社会貢献を目指している。
    また、台湾、マレーシア、タイの学術・学生交流協定校に毎年数名の研究室所属学生を短期留学生として派遣するとともに、毎年多くの協定校からの短期留学生及び修士課程留学生を受け入れている。これらの学生の指導、歓迎会・報告会のアレンジメント等を通して国際交流に貢献している。

Social Activities

  • HPLC講習会

    日本分析化学会九州支部  九州大学薬学部  2023.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • HPLC講習会

    日本分析化学会九州支部  九州大学薬学部  2022.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • HPLC講習会

    日本分析化学会九州支部  九州大学薬学部  2021.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 第６０回分析化学講習会

    日本分析化学会九州支部  九州大学薬学部  2019.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 第５９回分析化学講習会

    日本分析化学会九州支部  九州大学薬学部  2018.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 第５８回分析化学講習会

    日本分析化学会九州支部  九州大学伊都キャンパス  2017.8

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

▼display all