Updated on 2024/10/07

Information

 

写真a

 
MORIMOTO KAZUSHI
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Profile
2021〜 Molecular basis of pathophysiological functions by oxidized lipids 2014〜2021 Structural analysis of prostaglandin receptors for drug discovery 2007〜2013 Study on physiological functions of prostaglandin receptors

Degree

  • PhD

Research History

  • 京都大学、熊本大学

Research Interests・Research Keywords

  • Research theme:GPCR

    Keyword:GPCR

    Research period: 2024

  • Research theme:Molecular function of oxidized lipids

    Keyword:oxidized lipids

    Research period: 2021.4 - 2026.3

  • Research theme:structural analysis of prostaglandin receptors

    Keyword:prostaglandin, GPCR, X-ray crystallography

    Research period: 2014.1 - 2024.3

Awards

  • 奨励賞

    2020.1   日本薬学会関西支部   プロスタノイド受容体活性化機構の解明

Papers

  • Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex Reviewed

    Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi

    Cell Reports   40 ( 11 )   111323 - 111323   2022.9   ISSN:22111247 eISSN:22111247

     More details

    Authorship:Lead author   Language:Others   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Prostaglandin receptors have been implicated in a wide range of functions, including inflammation, immune response, reproduction, and cancer. Our group has previously determined the crystal structure of the active-like EP3 bound to its endogenous agonist, prostaglandin E₂. Here, we present the single-particle cryoelectron microscopy (cryo-EM) structure of the human EP3-Gi signaling complex at a resolution of 3.4 Å. The structure reveals the binding mode of Gi to EP3 and the structural changes induced in EP3 by Gi binding. In addition, we compare the structure of the EP3-Gi complex with other subtypes of prostaglandin receptors (EP2 and EP4) bound to Gs that have been previously reported and examine the differences in amino acid composition at the receptor-G protein interface. Mutational analysis reveals that the selectivity of the G protein depends on specific amino acid residues in the second intracellular loop and TM5.

    DOI: 10.1016/j.celrep.2022.111323

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

    Repository Public URL: https://hdl.handle.net/2324/7161470

  • Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface. Reviewed International journal

    Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, Shoichiro Horita, Keitaro Yamashita, Kunio Hirata, Yusuke Sekiguchi, Satoshi Yasuda, Mitsunori Shiroishi, Tomoko Shimizu, Yuji Urushibata, Yuta Kajiwara, Tomoaki Inazumi, Yunhon Hotta, Hidetsugu Asada, Takanori Nakane, Yuki Shiimura, Tomoya Nakagita, Kyoshiro Tsuge, Suguru Yoshida, Tomoko Kuribara, Takamitsu Hosoya, Yukihiko Sugimoto, Norimichi Nomura, Miwa Sato, Takatsugu Hirokawa, Masahiro Kinoshita, Takeshi Murata, Kiyoshi Takayama, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi

    Nature chemical biology   15 ( 1 )   18 - 26   2019.1

     More details

    Language:English  

    DOI: 10.1038/s41589-018-0131-3

  • Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. Reviewed International journal

    Kazushi Morimoto, Ryoji Suno, Yunhong Hotta, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi

    Nature chemical biology   15 ( 1 )   8 - 10   2019.1

     More details

    Language:English  

    DOI: 10.1038/s41589-018-0171-8

    Repository Public URL: https://hdl.handle.net/2324/7234022

  • Prostaglandin E-2-EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation Reviewed

    Kazushi Morimoto, Naritoshi Shirata, Yoshitaka Taketomi, Soken Tsuchiya, Eri Segi-Nishida, Tomoaki Inazumi, Kenji Kabashima, Satoshi Tanaka, Makoto Murakami, Shuh Narumiya, Yukihiko Sugimoto

    JOURNAL OF IMMUNOLOGY   192 ( 3 )   1130 - 1137   2014.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1300290

  • Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases. Reviewed International journal

    Ryota Mori, Masami Abe, Yuma Saimoto, Saki Shinto, Sara Jodai, Manami Tomomatsu, Kaho Tazoe, Minato Ishida, Masataka Enoki, Nao Kato, Tomohiro Yamashita, Yuki Itabashi, Ikuo Nakanishi, Kei Ohkubo, Sachiko Kaidzu, Masaki Tanito, Yuta Matsuoka, Kazushi Morimoto, Ken-Ichi Yamada

    Redox biology   73   103186 - 103186   2024.7   ISSN:2213-2317

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting oxidized lipids, particularly lipid-derived radicals critical in lipid peroxidation, which are known as radical-trapping antioxidants (RTAs), have been actively pursued. We focused our investigation on nitroxide compounds that have rapid second-order reaction rate constants for reaction with lipid-derived radicals. A novel screening system was developed by employing competitive reactions between library compounds and a newly developed profluorescence nitroxide probe with lipid-derived radicals to identify RTA compounds. A PubMed search of the top hit compounds revealed their wide application as repositioned drugs. Notably, the inhibitory efficacy of methyldopa, selected from these compounds, against retinal damage and bilateral common carotid artery stenosis was confirmed in animal models. These findings underscore the efficacy of our screening system and suggest that it is an effective approach for the discovery of RTA compounds.

    DOI: 10.1016/j.redox.2024.103186

    Web of Science

    Scopus

    PubMed

    researchmap

  • Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. Reviewed International journal

    Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-Ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi

    Nature communications   15 ( 1 )   2195 - 2195   2024.3   eISSN:2041-1723

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme of cholesterol biosynthesis, as a regulator of ferroptosis in hepatocytes. Genetic and pharmacological inhibition (with AY9944) of DHCR7 suppress ferroptosis in human hepatocellular carcinoma Huh-7 cells. DHCR7 inhibition increases its substrate, 7-dehydrocholesterol (7-DHC). Furthermore, exogenous 7-DHC supplementation using hydroxypropyl β-cyclodextrin suppresses ferroptosis. A 7-DHC-derived oxysterol metabolite, 3β,5α-dihydroxycholest-7-en-6-one (DHCEO), is increased by the ferroptosis-inducer RSL-3 in DHCR7-deficient cells, suggesting that the ferroptosis-suppressive effect of DHCR7 inhibition is associated with the oxidation of 7-DHC. Electron spin resonance analysis reveals that 7-DHC functions as a radical trapping agent, thus protecting cells from ferroptosis. We further show that AY9944 inhibits hepatic ischemia-reperfusion injury, and genetic ablation of Dhcr7 prevents acetaminophen-induced acute liver failure in mice. These findings provide new insights into the regulatory mechanism of liver ferroptosis and suggest a potential therapeutic option for ferroptosis-related liver diseases.

    DOI: 10.1038/s41467-024-46386-6

    Web of Science

    Scopus

    PubMed

    researchmap

  • Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells. Reviewed

    Manami Tomomatsu, Naoto Imamura, Hoshimi Izumi, Masatsugu Watanabe, Masataka Ikeda, Tomomi Ide, Shohei Uchinomiya, Akio Ojida, Mirinthorn Jutanom, Kazushi Morimoto, Ken-Ichi Yamada

    Biological & pharmaceutical bulletin   47 ( 3 )   641 - 651   2024.3   ISSN:09186158 eISSN:13475215

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Pharmaceutical Society of Japan  

    <p>Recently, mitochondrial dysfunction has gained attention as a causative factor in the pathogenesis and progression of age-related macular degeneration (AMD). Mitochondrial damage plays a key role in metabolism and disrupts the balance of intracellular metabolic pathways, such as oxidative phosphorylation (OXPHOS) and glycolysis. In this study, we focused on oxidized low-density lipoprotein (ox-LDL), a major constituent of drusen that accumulates in the retina of patients with AMD, and investigated whether it could be a causative factor for metabolic alterations in retinal pigment epithelial (RPE) cells. We found that prolonged exposure to ox-LDL induced changes in fatty acid β-oxidation (FAO), OXPHOS, and glycolytic activity and increased the mitochondrial reactive oxygen species production in RPE cells. Notably, the effects on metabolic alterations varied with the concentration and duration of ox-LDL treatment. In addition, we addressed the limitations of using ARPE-19 cells for retinal disease research by highlighting their lower barrier function and FAO activity compared to those of induced pluripotent stem cell-derived RPE cells. Our findings can aid in the elucidation of mechanisms underlying the metabolic alterations in AMD.</p>

    DOI: 10.1248/bpb.b23-00849

    Scopus

    PubMed

    CiNii Research

    researchmap

  • Ethoxyquin, a Lipid Peroxidation Inhibitor, Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion. Reviewed

    Masami Abe, Marie Sou, Yuta Matsuoka, Kazushi Morimoto, Ken-Ichi Yamada

    Biological & pharmaceutical bulletin   47 ( 1 )   104 - 111   2024.1   ISSN:09186158 eISSN:13475215

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Pharmaceutical Society of Japan  

    <p>White matter lesions induced by chronic cerebral hypoperfusion can cause vascular dementia; however, no appropriate treatments are currently available for these diseases. In this study, we investigated lipid peroxidation, which has recently been pointed out to be associated with cerebrovascular disease and vascular dementia, as a therapeutic target for chronic cerebral hypoperfusion. We used ethoxyquin, a lipid-soluble antioxidant, in a neuronal cell line and mouse model of the disease. The cytoprotective effect of ethoxyquin on glutamate-stimulated HT-22 cells, a mouse hippocampal cell line, was comparable to that of a ferroptosis inhibitor. In addition, the administration of ethoxyquin to bilateral common carotid artery stenosis model mice suppressed white matter lesions, blood–brain barrier disruption, and glial cell activation. Taken together, we propose that the inhibition of lipid peroxidation may be a useful therapeutic approach for chronic cerebrovascular disease and the resulting white matter lesions.</p>

    DOI: 10.1248/bpb.b23-00538

    Scopus

    PubMed

    CiNii Research

    researchmap

  • Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis Reviewed

    Kota Saito, Yuta Matsuoka, Masami Abe, Nao Kato, Kazushi Morimoto, Ken-ichi Yamada

    Redox Experimental Medicine   2023 ( 1 )   2023.1   eISSN:2755-158X

     More details

    Language:Others   Publishing type:Research paper (scientific journal)   Publisher:Bioscientifica  

    Graphical Abstract

    Abstract

    Objective

    Nonalcoholic steatohepatitis is a chronic liver disease caused by the progression of hepatocellular death and inflammation from simple steatosis. However, the pathogenesis of this disease remains unclear. Lipid peroxidation is one of the most critical factors in the development of nonalcoholic steatohepatitis; however, oxidised lipids – the products of lipid peroxidation – are insufficiently analysed. Here, we comprehensively analysed oxidised lipids in the liver during nonalcoholic steatohepatitis development in a choline-deficient, l-amino acid-defined, high-fat diet-fed mouse model.

    Methods

    Liver from C57BL/6J mice, fed a standard diet or a choline-deficient l-amino acid-defined high-fat diet for 1, 3, or 6 weeks, were collected to evaluate fibrosis, steatosis, inflammation, liver injury, and oxidised lipid production and to observe the suppression of these parameters upon vitamin E administration. In addition, organellar localisation of lipid peroxidation was assessed using fluorescence imaging. Finally, a mitochondria-targeted antioxidant was administered to model mice to investigate the mechanism underlying lipid peroxidation.

    Results

    We found an accumulation of oxidised triglycerides in the early stages of nonalcoholic steatohepatitis. Furthermore, our data indicate that oxidised triglycerides are generated by lipid peroxidation in lipid droplets due to mitochondria-derived reactive oxygen species.

    Conclusion

    These results suggest the importance of lipid droplet peroxidation in the progression of nonalcoholic steatohepatitis and may contribute to the development of therapeutic methods for nonalcoholic steatohepatitis in the future.

    Significance statement

    We demonstrate the specific and early occurrence of lipid peroxidation in nonalcoholic steatohepatitis pathogenesis and propose a previously unknown mechanism of disease progression.

    DOI: 10.1530/rem-22-0024

    researchmap

    Other Link: https://rem.bioscientifica.com/downloadpdf/journals/rem/2023/1/REM-22-0024.xml

  • Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein. Reviewed International journal

    Shingo Nojima, Yoko Fujita, Kanako Terakado Kimura, Norimichi Nomura, Ryoji Suno, Kazushi Morimoto, Masaki Yamamoto, Takeshi Noda, So Iwata, Hideki Shigematsu, Takuya Kobayashi

    Structure (London, England : 1993)   29 ( 3 )   252 - 260   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.str.2020.11.007

  • Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors Reviewed

    Satoshi Yasuda, Yuta Kajiwara, Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, So Iwata, Takuya Kobayashi, Takeshi Murata, Masahiro Kinoshita

    JOURNAL OF PHYSICAL CHEMISTRY B   121 ( 26 )   6341 - 6350   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jpcb.7b02997

  • Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors Reviewed

    Ryo Iwasaki, Kyoshiro Tsuge, Kazushi Morimoto, Tomoaki Inazumi, Osamu Kawahara, Atsuo Kawahara, Soken Tsuchiya, Yukihiko Sugimoto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   438 ( 2 )   353 - 358   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.07.075

  • Molecular and pharmacological characterization of zebrafish 'relaxant' prostanoid receptors Reviewed

    Kyoshiro Tsuge, Ryo Iwasaki, Kazushi Morimoto, Tomoaki Inazumi, Osamu Kawahara, Atsuo Kawahara, Soken Tsuchiya, Yukihiko Sugimoto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   436 ( 4 )   685 - 690   2013.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.06.017

  • Mast cell maturation is driven via a group III phospholipase A(2)-prostaglandin D-2-DP1 receptor paracrine axis Reviewed

    Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, Hiroyasu Sato, Remi Murase, Kei Yamamoto, Satoshi Tanaka, Mariko Sakanaka, Masanori Nakamura, Yasumasa Nishito, Momoko Kawana, Naotomo Kambe, Kazutaka Ikeda, Ryo Taguchi, Satoshi Nakamizo, Kenji Kabashima, Michael H. Gelb, Makoto Arita, Takehiko Yokomizo, Motonao Nakamura, Kikuko Watanabe, Hiroyuki Hirai, Masataka Nakamura, Yoshimichi Okayama, Chisei Ra, Kosuke Aritake, Yoshihiro Urade, Kazushi Morimoto, Yukihiko Sugimoto, Takao Shimizu, Shuh Narumiya, Shuntaro Hara, Makoto Murakami

    NATURE IMMUNOLOGY   14 ( 6 )   554 - +   2013.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ni.2586

  • 接触皮膚炎におけるプロスタグランジン受容体の機能と創薬への応用 Invited

    森本和志, 土屋創健, 杉本幸彦

    薬学雑誌   132 ( 11 )   1217 - 1223   2012.11

     More details

    Language:Japanese  

    DOI: 10.1248/yakushi.12-00232-2

  • Prostaglandin E₂-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism. Reviewed

    52 ( 8 )   1500 - 1508   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1194/jlr.M013615

  • Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling Reviewed

    Shigero Tamba, Rieko Yodoi, Kazushi Morimoto, Tomoaki Inazumi, Mamiko Sukeno, Eri Segi-Nishida, Yasushi Okuno, Gozoh Tsujimoto, Shuh Narumiya, Yukihiko Sugimoto

    BIOCHIMIE   92 ( 6 )   665 - 675   2010.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biochi.2010.04.006

  • Prostaglandin EP3 receptor superactivates adenylyl cyclase via the G(q)/PLC/Ca2+ pathway in a lipid raft-dependent manner Reviewed

    Kumiko Yamaoka, Akiko Yano, Kenji Kuroiwa, Kazushi Morimoto, Tomoaki Inazumi, Noriyuki Hatae, Hiroyuki Tabata, Eri Segi-Nishida, Satoshi Tanaka, Atsushi Ichikawa, Yukihiko Sugimoto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   389 ( 4 )   678 - 682   2009.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2009.09.064

  • RhoA/Rho Kinase Signaling in the Cumulus Mediates Extracellular Matrix Assembly Reviewed

    Rieko Yodoi, Shigero Tamba, Kazushi Morimoto, Eri Segi-Nishida, Mika Nishihara, Atsushi Ichikawa, Shuh Narumiya, Yukihiko Sugimoto

    ENDOCRINOLOGY   150 ( 7 )   3345 - 3352   2009.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2008-1449

  • Involvement of CD44 in mast cell proliferation during terminal differentiation Reviewed

    Hirotsugu Takano, Shunsuke Nakazawa, Naritoshi Shirata, Shigero Tamba, Kazuyuki Furuta, Sohken Tsuchiya, Kazushi Morimoto, Naoki Itano, Atsushi Irie, Atsushi Ichikawa, Koji Kimata, Kazuhisa Nakayama, Yukihiko Sugimoto, Satoshi Tanaka

    LABORATORY INVESTIGATION   89 ( 4 )   446 - 455   2009.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2008.159

▼display all

Presentations

  • 脂質過酸化反応が引き起こす生体応答 Invited

    森本和志, 松岡悠太, 山田健一

    第96日本生化学会大会  2023.10 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 血管性認知症モデルマウスにおける脂質過酸化反応阻害剤の炎症抑制効果

    萩森諒、阿部真紗美、JUTANOM Mirinthorn、森本和志、山田健一

    日本薬学会第144年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese  

    Country:Japan  

  • 極性頭部が修飾された酸化フォスファチジルエタノールアミン解析手法の開発

    廣保郁、小櫻英翔、、JUTANOM Mirinthorn、森本和志、山田健一

    日本薬学会第144年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese  

    Country:Japan  

  • クリックケミストリーに応用可能な脂質ラジカル検出プローブの開発

    川野蒼太、田中萌、齋藤耕太、松岡悠太、森本和志、JUTANOM Mirinthorn、山田健一

    日本薬学会第144年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese  

    Country:Japan  

  • ox-LDLはヒト網膜色素上皮細胞の代謝変容を誘導する

    友松愛美、今村直人、和泉星余、池田昌隆、井手友美、内之宮祥平、王子田彰夫、JUTANOM Mirinthorn、森本和志、山田健一

    日本薬学会第144年会  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese  

    Country:Japan  

  • リソソームでの脂質過酸化反応がフェロトーシス誘導を亢進する

    #津波古 光生、#斎元 祐真、@森本 和志、@松岡 悠太、@唐澤 悟、@山田 健一

    日本薬学会第143年会  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  • 炎症反応を惹起する酸化リン脂質の探索

    #上野 亮哉、#小櫻 英翔、#岩尾 彬広、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会第143年会  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  • 脂質過酸化反応抑制剤の探索と血管性認知症モデルマウスへの適用

    #阿部 真紗美、#宗 茉里恵、#進藤 早紀、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会第143年会  2023.3 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  • リソソーム脂質過酸化反応はリソソーム膜破壊を介してフェロトーシスを誘導する

    #斎元祐真、@森本和志、#日下部大樹、@松岡悠太、@平山佑、@唐澤悟、@山田健一

    第61回電子スピンサイエンス学会  2022.12 

     More details

    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • ニトロキシドプローブを用いた脂質ラジカル付加体精製法の開発と応用

    #田中萌、#齋藤耕太、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@森本和志、@山田健一

    第61回電子スピンサイエンス学会  2022.12 

     More details

    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • チオール基反応性求電子性酸化脂質を捕捉する蛍光プローブの開発および応用

    #田添佳歩、@松岡悠太、@高橋政友、@和泉自泰、@馬場健史、@森本和志、@山田健一

    第61回電子スピンサイエンス学会  2022.12 

     More details

    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 鉄過剰症における血漿中脂質関連因子の解析

    #松田 和、@松岡 悠太、@森本 和志、@山田 健一

    第39回日本薬学会九州山口支部大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 薬用植物抽出液ライブラリーを用いたフェロトーシス抑制剤の探索

    #城戸 百香、@松岡 悠太、@森本 和志、@山田 健一

    第39回日本薬学会九州山口支部大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 光誘発性網膜障害に対する脂質過酸化反応抑制剤 X の抑制効果

    #森 亮太、#城臺 更、@海津 幸子、@谷戸 正樹、@松岡 悠太、@森本 和志、@山田 健一

    第39回日本薬学会九州山口支部大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • プロスタグランジン IP 受容体経路によるマスト細胞Alarmin 応答の抑制機構

    @中島 周作、@南 伊織、@佐々木 諒也、@中尾 優子、@村上 里穂、@宮本 卓馬、@鈴木 佑治、@渡辺 真由帆、@森本 和志、@稲住 知明、@土屋 創健、@杉本 幸彦

    第39回日本薬学会九州山口支部大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 脂質過酸化反応抑制剤は光誘発性網膜障害を抑制する

    #森 亮太、#城臺 更、#石田 南人、#進藤 早紀、@海津 幸子、 @谷戸 正樹、@松岡 悠太、@森本 和志、@山田 健一

    第95回日本生化学会大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、@森本和志、#日下部大樹、@松岡悠太、@唐澤悟、@山田健一

    第95回日本生化学会大会  2022.11 

     More details

    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 脂質過酸化反応抑制剤の血管性認知症モデルに対する病態保護効果

    #阿部 真紗美、#宗 茉里恵、@松岡 悠太、@森本 和志、@山田 健一

    日本薬学会第142年会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@山田健一

    第38回日本薬学会九州山口支部  2021.11 

     More details

    Event date: 2021.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • プロスタノイドIP受容体はエピゲノム制御を介してマスト細胞の炎症応答を抑制する

    @南伊織、@佐々木諒也、@中尾優子、@村上里穂、@鈴木佑治、@渡辺真由帆、@森本和志、@稲住知明、@土屋創建、@杉本幸彦

    第38回日本薬学会九州山口支部  2021.11 

     More details

    Event date: 2021.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@山田健一

    レドックスR&D 戦略委員会 第1回若手シンポジウム  2021.11 

     More details

    Event date: 2021.11

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • プロスタグランジン受容体の立体構造解析 Invited

    @森本和志、@寿野良二、@小林拓也

    第42回生体膜と薬物の相互作用シンポジウム  2021.10 

     More details

    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • リソソームの脂質過酸化反応がフェロトーシス誘導を亢進する

    #斎元祐真、#日下部大樹、@森本和志、@松岡悠太、@唐澤悟、@山田健一

    第42回生体膜と薬物の相互作用シンポジウム  2021.10 

     More details

    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ヒトプロスタグランジンE2受容体EP3-Gタンパク質複合体のクライオ電子顕微鏡単粒子解析

    @寿野良二、@杉田征彦、@森本和志、@辻本浩一、@廣瀬未果、@寿野千代、@野村紀通、@岩崎憲二、@加藤貴之、@岩田想、@小林拓也

    第21回日本蛋白質科学会年会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Japan  

  • プロスタグランジンI2によるマスト細胞応答の制御

    宮本卓馬, 鈴木佑治, 村上里穂, 渡辺真由帆, 森本和志, 稲住知明, 稲住知明, 土屋創健, 土屋創健, 杉本幸彦, 杉本幸彦

    生体膜と薬物の相互作用シンポジウム講演要旨集  2015.11 

     More details

    Language:Japanese  

    Country:Japan  

  • Towards structure determination of the human prostanoid receptor bound to the antibody International conference

    Y. Toyoda, K. Morimoto, R. Suno, Y. Sekiguchi, K. Yamashita, K. Hirata, S. Yasuda, H. Asada, T. Nakane, Y. Shiimura, T. Nakagita, T. Inazumi, K. Tsuge, Y. Kajiwara, T. Shimizu, Y. Urushibata, S. Yoshida, T. Kuribara, T. Hosoya, M. Kinoshita, Y. Sugimoto, N. Nomura, T. Murata, K. Takayama, M. Yamamoto, S. Narumiya, S. Iwata, T. Kobayashi

    GPCR workshop 2015  2015.12 

     More details

    Language:Others  

    Country:United States  

    Towards structure determination of the human prostanoid receptor bound to the antibody

  • プロスタサイクリンIP受容体がマスト細胞炎症性応答に与える影響

    村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 稲住知明, 土屋創健, 土屋創健, 成宮周, 杉本幸彦, 杉本幸彦

    日本薬学会九州支部大会講演要旨集  2016.11 

     More details

    Language:Japanese  

    Country:Japan  

  • マスト細胞炎症性応答に対するプロスタサイクリンIP受容体の役割

    村上里穂, 中尾優子, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 稲住知明, 土屋創健, 土屋創健, 成宮周, 杉本幸彦, 杉本幸彦

    脂質生化学研究  2018.5 

     More details

    Language:Japanese  

    Country:Japan  

  • マスト細胞炎症性応答におけるプロスタサイクリンIP受容体の役割

    村上里穂, 中尾優子, 宮本卓馬, 渡辺真由帆, 森本和志, 稲住知明, 稲住知明, 土屋創健, 土屋創健, 成宮周, 杉本幸彦, 杉本幸彦

    次世代を担う若手ファーマ・バイオフォーラム講演要旨集  2018.9 

     More details

    Language:Japanese  

    Country:Japan  

  • シリルアリールトリフラート型のチエノベンザイン前駆体の合成と多置換ベンゾチオフェン合成への応用

    吉田優, 栗原ともこ, 森田隆太, 松澤翼, 森本和志, 小林拓也, 細谷孝充

    日本化学会春季年会講演予稿集(CD-ROM)  2018.3 

     More details

    Language:Japanese  

    Country:Japan  

  • Theoretical Identification of Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A International conference

    S. Yasuda, Y. Kajiwara, Y. Toyoda, K.Morimoto, R. Suno, S. Iwata, T. Kobayashi, T. Murata, M. Kinoshita

    2018.2 

     More details

    Language:Others  

    Country:United States  

    Theoretical Identification of Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A

  • Identification of thermostabilizing mutations for G-protein coupled receptors: Rapid method based on statistical thermodynamics

    S. Yasuda, Y. Kajiwara, Y. Takamuku, N. Suzuki, Y. Toyoda, K. Morimoto, R. Suno, S. Iwata, T. Kobayashi, T. Murata, M. Kinoshita

    2018.4 

     More details

    Language:Others  

    Country:Japan  

    Identification of thermostabilizing mutations for G-protein coupled receptors: Rapid method based on statistical thermodynamics

  • プロスタサイクリンによるマスト細胞応答のエピゲノム制御の分子機構

    佐々木 諒也, 中尾 優子, 村上 里穂, 鈴木 佑治, 渡辺 真由帆, 森本 和志, 稲住 知明, 土屋 創健, 杉本 幸彦

    脂質生化学研究  2020.5 

     More details

    Language:Japanese  

    Country:Japan  

  • リソソームにおける脂質過酸化反応がフェロトーシス誘導を亢進する

    斎元祐真, 日下部大樹, 森本和志, 森本和志, 松岡悠太, 松岡悠太, 唐澤悟, 山田健一, 山田健一

    日本薬学会九州支部大会講演要旨集  2021.11 

     More details

    Language:Others  

    Country:Japan  

  • プロスタノイドIP受容体はエピゲノム制御を介してマスト細胞の炎症応答を抑制する

    南伊織, 佐々木諒也, 中尾優子, 村上里穂, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創建, 杉本幸彦

    日本薬学会九州支部大会講演要旨集  2021.11 

     More details

    Language:Others  

    Country:Japan  

  • リソソームでの脂質過酸化反応がフェロトーシス誘導を亢進する

    #津波古光生, #斎元祐真, 森本和志, 松岡悠太, 唐澤悟, 山田健一

    日本薬学会第143年会  2023.3 

     More details

    Language:Others  

    Country:Japan  

  • プロスタグランジン受容体の構造解析によるシグナル伝達機構の解明

    寿野良二, 森本和志, 豊田洋輔, 野島慎五, 小林(清水)拓也

    日本薬学会第143年会  2023.3 

     More details

    Language:Others  

    Country:Japan  

  • リソソーム脂質過酸化反応はリソソーム膜を破壊しフェロトーシスを誘導する

    斎元祐真, 森本和志, 日下部大樹, 松岡悠太, 平山佑, 唐澤悟, 山田健一

    第65回日本脂質生化学会  2023.6 

     More details

    Language:Others  

    Country:Japan  

  • リソソームの脂質過酸化反応がフェロトーシス誘導の引き金になる

    斎元祐真, 日下部大樹, 森本和志, 松岡悠太, 唐澤悟, 平山祐, 山田健一

    第22回次世代を担う若手のためのファーマ・バイオフォーラム  2023.9 

     More details

    Language:Others  

    Country:Japan  

  • 脂質過酸化反応抑制剤の探索と慢性脳低灌流モデルマウスへの適用

    阿部真紗美, 宗茉里恵, 進藤早紀, 松岡悠太, JUTANOM Mirinthorn, 森本和志, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • 網膜色素上皮細胞で生じる代謝変動におけるox-LDLの関与

    友松愛美, 今村直人, 和泉星余, 池田昌隆, 井手友美, 森本和志, 山田健一

    第96日本生化学会大会  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • 網膜色素上皮細胞で生じる代謝変動に対するox-LDLの作用解明

    友松愛美, 今村直人, 和泉星余, 池田昌隆, 井手友美, 内之宮祥平, 王子田彰夫, JUTANOM Mirinthorn, 森本和志, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • 炎症反応を制御する酸化リン脂質の探索

    上野亮哉, 岩尾彬広, 小櫻英翔, 高橋政友, 和泉自泰, 馬場健史, 松岡悠太, 森本和志, 山田健一

    第96日本生化学会大会  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • 求電子性酸化脂質を捕捉する蛍光プローブの開発

    田添佳歩, 松岡悠太, 高橋政友, 和泉自泰, 馬場健史, 森本和志, MIRINTHORN Jutanom, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • 固相精製プローブを用いた微量脂質ラジカル検出法の開発と応用

    田中萌, 齋藤耕太, 松岡悠太, 高橋政友, 和泉自泰, 馬場健史, MIRINTHORN Jutanom, 森本和志, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • リソソーム脂質過酸化反応によるリソソーム破壊がフェロトーシスを誘導する

    斎元祐真, 森本和志, 日下部大樹, 松岡悠太, 平山佑, 唐澤悟, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • ミクログリアの炎症応答を制御する新規酸化リン脂質の探索

    上野亮哉, 岩尾彬広, 小櫻英翔, 高橋政友, 和泉自泰, 馬場健史, 加藤俊治, 仲川清隆, 松岡悠太, JUTANOM Mirinthorn, 森本和志, 山田健一

    第44回生体膜と薬物の相互作用シンポジウム  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • プロスタサイクリンはマスト細胞のエピゲノム制御によりAlarmin応答を抑制する

    中島周作, 南伊織, 佐々木諒也, 中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創建, 杉本幸彦

    第96日本生化学会大会  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • フェロトーシスを特徴づける酸化リン脂質の探索

    陣内優佳, 中英人, 伊藤綾人, MIRINTHORN Jutanom, 森本和志, 山田健一

    第96日本生化学会大会  2023.10 

     More details

    Language:Others  

    Country:Japan  

  • Determination of the responsible gene for oxidized phosphatidylcholine translocation in apoptosis

    2023.10 

     More details

    Language:Others  

    Country:Japan  

    Determination of the responsible gene for oxidized phosphatidylcholine translocation in apoptosis

  • 蛍光プローブを用いたチオール基反応性求電子性酸化脂質の探索

    田添佳歩, 松岡悠太, 高橋政友, 和泉自泰, 馬場健史, 森本和志, JUTANOM Mirinthorn, 山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

     More details

    Language:Others  

    Country:Japan  

  • 機能性ニトロキシドプローブを用いた微量脂質ラジカル付加体精製法の開発と応用

    田中萌, 齋藤耕太, 松岡悠太, 高橋政友, 和泉自泰, 馬場健史, JUTANOM Mirinthorn, 森本和志, 山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

     More details

    Language:Others  

    Country:Japan  

  • フェロトーシス耐性に対するAKR1Cの関与

    吉田汐里, 森本和志, 松岡悠太, JUTANOM Mirinthorn, 山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

     More details

    Language:Others  

    Country:Japan  

  • ヒト網膜色素上皮細胞の代謝変容に対するox-LDLの作用

    友松愛美, 今村直人, 和泉星余, 池田昌隆, 井手友美, 内之宮祥平, 王子田彰夫, JUTANOM Mirinthorn, 森本和志, 山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

     More details

    Language:Others  

    Country:Japan  

  • オキシリピドミクス解析を用いたミクログリアの炎症応答を制御する新規酸化リン脂質の同定

    上野亮哉, 岩尾彬広, 小櫻英翔, 高橋政友, 和泉自泰, 馬場健史, 加藤俊治, 仲川清隆, 松岡悠太, JUTANOM Mirinthorn, 森本和志, 山田健一

    第40回日本薬学会九州山口支部大会  2023.11 

     More details

    Language:Others  

    Country:Japan  

▼display all

MISC

  • 分子から迫る神経薬理学 プロスタノイド受容体の構造

    森本 和志

    2020.4

     More details

    Language:Japanese  

  • 分子から迫る神経薬理学 プロスタノイド受容体をターゲットとした臨床応用

    森本 和志

    2020.3

     More details

    Language:Japanese  

  • 分子から迫る神経薬理学 プロスタノイド受容体の生理的および薬理的作用

    森本 和志

    2020.2

     More details

    Language:Japanese  

  • 分子から迫る神経薬理学 プロスタノイド受容体の種類

    森本 和志

    2020.1

     More details

    Language:Japanese  

  • 生物系薬学 クライオ電子顕微鏡で見えてきたグルタミン酸受容体活性化のメカニズム

    森本 和志

    ファルマシア   2019.10

     More details

    Language:Japanese  

  • プロスタグランジン研究の新展開―エイコサノイド周辺脂質を含めた研究動向 4.抗原非依存性急性炎症におけるプロスタグランジンの役割

    杉本幸彦, 森本和志, 土屋創健

    血栓と循環   2013.12

     More details

    Language:Japanese  

  • サイトカインの種類 4.ケモカイン 23)CCL7

    杉本幸彦, 森本和志

    月刊臨床免疫・アレルギー科   2012.5

     More details

    Language:Japanese  

▼display all

Professional Memberships

  • PROTEIN SCIENCE SOCIETY OF JAPAN

  • The Japanese Conference on the Biochemistry of Lipids

  • THE JAPANESE BIOCHEMICAL SOCIETY

  • THE PHARMACEUTICAL SOCIETY OF JAPAN

Academic Activities

  • 実行委員、事務局員

    第44回生体膜と薬物の相互作用シンポジウム  ( 九州大学(福岡市) ) 2023.10

     More details

    Type:Competition, symposium, etc. 

    Number of participants:124

Research Projects

  • プロスタグランジン受容体を標的とした構造に基づく創薬

    Grant number:20H03434  2020 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 構造情報に基づく脂質シグナル分子の認識機構の解明

    Grant number:15J00102  2015 - 2017

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

      More details

    Grant type:Scientific research funding

  • プロスタグランジン受容体による細胞特異的シグナリングの分子機構

    Grant number:10J02074  2010 - 2012

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

      More details

    Grant type:Scientific research funding

Class subject

  • 物理薬学演習I

    2023.10 - 2024.3   Second semester

  • 物理薬学演習II

    2023.10 - 2024.3   Second semester

  • 薬学基礎実習II

    2023.4 - 2023.6   Spring quarter

  • 物理薬学演習I

    2022.10 - 2023.3   Second semester

  • 物理薬学演習II

    2022.10 - 2023.3   Second semester

  • 薬学基礎実習II

    2022.6 - 2022.8   Summer quarter

  • 物理薬学研究

    2022.4 - 2023.3   Full year

  • 物理化学的測定法

    2022.4 - 2022.9   First semester

  • 物理薬学演習I

    2021.10 - 2022.3   Second semester

  • 物理薬学演習II

    2021.10 - 2022.3   Second semester

  • 物理薬学研究

    2021.4 - 2022.3   Full year

  • 物理化学的測定法

    2021.4 - 2021.9   First semester

  • 薬学基礎実習II

    2021.4 - 2021.6   Spring quarter

▼display all

FD Participation

  • 2024.3   Role:Participation   Title:有体物管理センターの業務および成果有体物収入の配分率の変更について

    Organizer:University-wide

  • 2023.11   Role:Participation   Title:第2回部局FD講演会「機関間連携」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role:Participation   Title:令和5年度4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.11   Role:Participation   Title:第4回創薬産学官連携セミナー(アカデミア創薬)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role:Participation   Title:学生の多様性に対応した教育とは:障害学生への合理的配慮を中心に

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role:Participation   Title:第3回創薬産学官連携セミナー(感染症研究拠点WG共催)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.12   Role:Participation   Title:電子教材著作権講習会

    Organizer:University-wide

  • 2021.9   Role:Participation   Title:JST 次世代研究者挑戦的研究プログラム 説明会

    Organizer:University-wide

  • 2021.7   Role:Participation   Title:生体防御医学研究所FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.5   Role:Participation   Title:第2回創薬産学官連携セミナー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Media Coverage

  • 社会欄にてPG受容体の構造論文が取り上げられた Newspaper, magazine

    朝日新聞  2018.12

     More details

    社会欄にてPG受容体の構造論文が取り上げられた

  • 科学欄にてPGによる炎症惹起機構の論文が取り上げられた Newspaper, magazine

    熊本日日新聞  2014.2

     More details

    科学欄にてPGによる炎症惹起機構の論文が取り上げられた