Updated on 2024/10/01

Information

 

写真a

 
TAGAMI TAKUMA
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Profile
アンモニアやアミンの精密変換反応の開発に取り組んでいる。反応や触媒の設計により、安価なアミン類を付加価値に高い複雑なアミンへと変換する手法を開発する。
External link

Degree

  • Ph.D. (Eng.)

Research History

  • ２０２０年４月–2021年3月　国立研究開発法人理化学研究所　特別研究員 ２０２１年４月–2023年11月　国立研究開発法人理化学研究所　基礎科学特別研究員

    ２０２０年４月–2021年3月　国立研究開発法人理化学研究所　特別研究員 ２０２１年４月–2023年11月　国立研究開発法人理化学研究所　基礎科学特別研究員

  • 2023年12月– 九州大学大学院薬学研究院　助教

Research Interests・Research Keywords

  • Research theme：Transformation of simple amines into valuable amines

    Keyword：reaction development, amines

    Research period： 2023.12 - 2024.4

Awards

  • 第45回フッ素化学討論会優秀口頭発表賞

    2022.11   日本フッ素化学会  

  • 第12回大津会議アワードフェロー

    2021.10   MSD生命科学財団  

Papers

  • Aerobic Photoredox Catalyzed Oxamate Ester Synthesis from Bromodifluoroacetate Esters

    Tagami, T; Kawamura, S; Sodeoka, M

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   27 ( 23 )   2024.6   （ ISSN:1434-193X eISSN:1099-0690 ）

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    Publisher：European Journal of Organic Chemistry  

    Here we report an aerobic photoredox catalysis approach to oxamate ester synthesis using bromodifluoroacetate esters and amines under open-air conditions. Oxamate ester is an important skeleton found in bioactive molecules and used as a synthetic building block. However, previous synthetic methods require the use of moisture- and air-sensitive precursors and/or harsh conditions, limiting accessible oxamate esters. The present method uses bench-stable bromodifluoroacetate esters and amines under mild photoredox catalytic conditions to furnish a wide variety of oxamate esters. Combining photoredox catalysis with aerobic oxygenation enables the use of bromodifluoroacetate ester as a precursor for the synthesis of oxamate esters via fluoroglyoxylate esters.

    DOI： 10.1002/ejoc.202400265

    Web of Science

    Scopus

  • Catalytic Difluoromethylation of Alkenes with Difluoroacetic Anhydride: Reactivity of Fluorinated Diacyl Peroxides and Radicals Reviewed International journal

    Takuma Tagami, Yusuke Mitani, Shintaro Kawamura, Mikiko Sodeoka

    Advanced Synthesis & Catalysis   365 ( 21 )   3637 - 3647   2023.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/adsc.202300337

  • 1,2-Bis-perfluoroalkylations of alkenes and alkynes with perfluorocarboxylic anhydrides via the formation of perfluoroalkylcopper intermediates Reviewed International journal

    Takuma Tagami, Yuma Aoki, Shintaro Kawamura, Mikiko Sodeoka

    Organic & Biomolecular Chemistry   19 ( 42 )   9148 - 9153   2021.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/D1OB01529J

  • Determination of acid dissociation constants of flavin analogues by capillary zone electrophoresis Reviewed International journal

    Yuki Tanikami, Takuma Tagami, Mayu Sakamoto, Yukihiro Arakawa, Hitoshi Mizuguchi, Yasushi Imada, Toshio Takayanagi

    Electrophoresis   41 ( 15 )   1316 - 1325   2020.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/elps.202000066

  • Efficient Use of Photons in Photoredox/Enamine Dual Catalysis with a Peptide-Bridged Flavin–Amine Hybrid Reviewed International journal

    21 ( 17 )   6978 - 6982   2019.8

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.orglett.9b02567

Professional Memberships

  • The Chemical Society of Japan

  • The Society of Synthetic Organic Chemistry, Japan

  • The Society of Fluorine Chemistry, Japan

  • 日本薬学会

Research Projects

Class subject

  • 薬学基礎実習I

    2023.10 - 2024.3   Second semester

  • 医薬化学演習I

    2023.4 - 2023.9   First semester

  • 医薬化学演習II

    2023.4 - 2023.9   First semester