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写真a

ゴトウ マサヒロ
後藤 雅宏
GOTO MASAHIRO
所属
工学研究院 応用化学部門 教授
工学研究院 附属次世代経皮薬物送達研究センター(併任)
未来化学創造センター (併任)
工学部 応用化学科(併任)
工学府 応用化学専攻(併任)
職名
教授
プロフィール
以下のような研究を行っています。  1. 創薬工学ならびに経皮ワクチンに関する研究     注射を必要とするようなバイオ製剤の経口製剤化ならびに経皮吸収製剤化。     インスリン、GLP-1受容体作動薬、インフルエンザ、花粉症などのアレルギーに関する経皮ワクチン開発に関する研究を行っています.  2. 機能性化粧品の開発     肌への高浸透処方技術(SO技術)を利用した高機能生化粧品開発に関する研究を行っています。     皮膚の高浸透技術を利用した機能性化粧品 (商品名:VIVCO, プリエクラ, T3など)の開発  3. イオン液体のDDSへの応用    イオン液体という特殊な溶剤を用いた薬剤調製。特に、生体適合性イオン液体の開発に注力しています。    抗がん剤への応用さらに、様々な薬剤の経皮吸収製剤へのイオン液体の利用を検討しています。   イオン液体による核酸医薬(mRNAなど)の経皮吸収製剤の開発を行っています。  4. レアメタルの高効率リサイクル技術の開発     金属資源を効率よく分離回収するシステムを開発しています.特に、環境に配慮した有機溶剤を使用しないイオン液体や深共晶溶媒を利用した     金属リサイクルシステムを開発しています.また、金属回収における膜技術の利用も研究しています。  5. 新規機能性バイオ材料の開発    分子の自己集積機能を応用した超分子ゲルの開発      教育   物理化学および反応工学に関する講義を担当しています.
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研究分野

  • ものづくり技術(機械・電気電子・化学工学) / バイオ機能応用、バイオプロセス工学

  • ものづくり技術(機械・電気電子・化学工学) / 反応工学、プロセスシステム工学

  • ものづくり技術(機械・電気電子・化学工学) / 移動現象、単位操作

学位

  • 工学博士

経歴

  • ASPION株式会社 社外取締役 2004年12月-2010年8月 SOファーマ株式会社 C.E.O. 2010年9月ー2013年3月 ココカラファインネクスト(株)最高技術顧問2013年4月ー2019年3月 NOVIGO Pharma 技術顧問 アドファーマ 技術アドバイザー

    ASPION株式会社 社外取締役 2004年12月-2010年8月 SOファーマ株式会社 C.E.O. 2010年9月ー2013年3月 ココカラファインネクスト(株)最高技術顧問2013年4月ー2019年3月 NOVIGO Pharma 技術顧問 アドファーマ 技術アドバイザー

研究テーマ・研究キーワード

  • 研究テーマ:DDS

    研究キーワード:DDS

    研究期間: 2024年

  • 研究テーマ:イオン液体

    研究キーワード:イオン液体

    研究期間: 2024年

  • 研究テーマ:レアメタルリサイクル

    研究キーワード:レアメタルリサイクル

    研究期間: 2024年

  • 研究テーマ:創薬工学

    研究キーワード:創薬工学

    研究期間: 2024年

  • 研究テーマ:界面工学

    研究キーワード:界面工学

    研究期間: 2024年

  • 研究テーマ:経皮ワクチン

    研究キーワード:経皮ワクチン

    研究期間: 2024年

  • 研究テーマ:S/O化技術を利用した機能性化粧品(VIVCO)の開発

    研究キーワード:化粧品

    研究期間: 2009年1月 - 2028年3月

  • 研究テーマ:レアメタル金属の高効率リサイクルプロセスの開発

    研究キーワード:レアメタル,リサイクル,抽出

    研究期間: 2007年4月 - 2028年3月

  • 研究テーマ:イオン液体のバイオテクノロジー(創薬)への応用

    研究キーワード:酵素、タンパク質、遺伝子、分離、界面

    研究期間: 2006年4月 - 2028年3月

  • 研究テーマ:次世代経皮吸収技術(S/O)を利用した低侵襲性経皮ワクチンの創成

    研究キーワード:酵素、タンパク質、遺伝子、分離、界面

    研究期間: 2004年12月 - 2028年3月

  • 研究テーマ:次世代経皮吸収技術を利用した花粉症経皮ワクチンの創成

    研究キーワード:酵素、タンパク質、遺伝子、分離、界面

    研究期間: 1990年6月 - 2028年3月

受賞

  • 日本溶媒抽出学会 学会賞

    2019年11月   溶媒抽出法の生体分子への応用とイオン液体を用いた先導的研究

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    独自に開発した様々なイオン液体を用いて、Au, Pt, Pd, Rhをはじめとした貴金属の抽出分離に応用し、イオン液体の抽出溶媒としての有効性を実証している。イオン液体の溶媒抽出応用に関しては、希釈剤としての利用ならびにイオン液体そのものを抽出剤として利用する2つに大別される。研究の初期は、上記代表論文に示されるような希釈剤としての抽出促進効果が注目されていたが、最近は、イオン液体自信を抽出試薬として利用する研究にシフトしている。イオン液体研究で、最大の課題であった抽出に伴いカウンターアニオンが原料相に漏洩する問題を、疎水性の高いホスホニウムカチオンにClアニオンを利用したイオン液体で、繰り返しの利用をも可能とするイオン液体を開発した点も独創性が高い。

  • 日本海水学会 学会賞

    2019年6月   日本海水学会   海底資源からのレアメタルの高効率分離回収プロセスの構築

  • 化学工学会 学会賞

    2019年3月   化学工学会   両親媒性分子を基体とした生物化学工学における新分野開拓

  • 九州大学研究活動表彰

    2017年12月  

  • 九州大学研究活動表彰

    2016年12月  

  • 日本イオン交換学会学会賞

    2015年10月   日本イオン交換学会   生物機能ならびに生物材料を利用した高性能イオン交換材料の開発

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    生物機能ならびに生物材料を利用した高性能イオン交換材料の開発に関して、これまで発表した400編以上の業績が認められ、日本イオン交換学会の学会賞が授与された。

  • 日本生物工学会論文賞

    2014年7月   日本生物工学会   タンパク質コンジュゲートを用いた遺伝子検出に関する研究

  • 九州大学研究活動表彰

    2012年11月   九州大学   産学連携研究

  • 日本海水学会研究賞

    2012年5月   日本海水学会   金属イオンの高度分離を目的とした包摂認識化合物の分子設計に関する研究

  • アジア生物化学工学会功労賞(YABEC Award 2011)

    2011年11月   アジア生物化学工学会(AFOB)   アジア地域の生物化学工学の発展に寄与した功績

  • 九州先端科学技術研究開発NT企業大賞

    2010年10月   ISIT九州先端科学技術研究開発表彰   ナノテクノロジーを利用した化粧品の実用化

  • 日本食品科学会論文賞

    2009年9月   日本食品科学工学会   遺伝子による食品検査法の開発

  • APBioChE2007 最優秀ポスター賞

    2007年11月   アジア環太平洋生物工学委員会   酵素反応を用いた生体分子の融合技術の開発

  • 日本生物工学会論文賞 道添純二、一瀬博文、丸山達生、神谷典穂、後藤雅宏

    2006年9月   日本生物工学会   Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions

  • 生物工学会論文賞

    2006年9月   日本生物工学会   人工疑似触媒の構築と物質生産への応用

  • Best Presentation Award

    2005年10月   International Solvent Extraction Sci.  

  • 化学工学会研究賞

    2005年3月   化学工学会   分子集合体の生物工学への応用展開

  • 生物工学会論文賞

    2004年9月   日本生物工学会   分子集合体を用いる変性タンパク質の活性回復に関する研究

  • 研究奨励賞

    2001年5月   日本膜学会   ナノ集合体の生物工学的応用

  • 論文賞

    1990年3月   化学工学会   乳化型液膜法のための界面活性剤の開発

▼全件表示

論文

  • Ionic Liquid-Mediated Ethosome for Transdermal Delivery of Insulin 招待 査読 国際誌

    FH Nabila, R Islam, IM Shimul, M Moniruzzaman, R Wakabayashi, N Kamiya, M Goto,

    Chem. Commun   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.1039/D3CC06130B

  • Amino Acid-Based Ionic Liquids as Biocompatible Extractants for Critical and Precious Metals 査読 国際誌

    A Maghfirah, T Hanada, ATN Fajar, M Goto

    ACS Sustainable Chemistry & Engineering   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.1021/acssuschemeng.4c01799

  • Ionic Liquid-Based patch formulation for enhanced transdermal delivery of sparingly soluble drug

    Islam, R; Nabila, FH; Wakabayashi, R; Kamiya, N; Moniruzzaman, M; Goto, M

    JOURNAL OF MOLECULAR LIQUIDS   397   2024年3月   ISSN:0167-7322 eISSN:1873-3166

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Liquids  

    Ionic liquid (IL)-based transdermal formulations have gained significant attention because of their high skin penetration efficiency and ease of design. However, many IL-based formulations exhibit low viscosity, which hinders direct administration and leads to less efficient drug delivery. Therefore, there is a pressing need for specialized formulations with improved viscosity and efficacy as a drug delivery platform. In this study, we report a ready-to-use transdermal patch system utilizing IL-in-oil (IL/O) microemulsions to deliver acyclovir, a sparingly soluble antiviral drug. To prepare the patch system, a mixture containing equal weights of IL/O microemulsions and adhesive (Durotak 87–4098) was homogenized, subsequently coated on a liner, and covered by a support film. These patches were produced with varying thicknesses (100 μm, 200 μm, 300 μm, and 500 μm) via a solvent evaporation technique. A 24-hour in vitro skin permeation study revealed that the thinnest patch (100 μm) delivered more than 45 % of the loaded drug. Drug delivery rate gradually reduced as the patch thickness increased, accounting for 22 % and 14 % drug permeation by 200 μm and 300 μm patches respectively. A 30-day stability study at room temperature demonstrated that neither the physical appearance nor the active ingredient content changed, validating the physical and chemical stability of the patches. Skin permeation mechanism by Fourier transform infrared spectroscopic analysis of the skin suggested that the IL/O patch possesses the capability to modify the lipid barrier in the stratum corneum thus facilitating drug diffusion. In vitro skin irritation studies on reconstructed human epidermal tissue and Yucatan micropig skin revealed that the patch exhibits no skin irritation. We believe that the adhesive nature of this newly developed IL-based patch holds significant promise as a transdermal drug delivery platform.

    DOI: 10.1016/j.molliq.2024.124184

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  • Hydrophobic deep eutectic solvents for the direct leaching of nickel laterite ores: Selectivity and reusability investigations

    Sakamoto, T; Hanada, T; Sato, H; Kamisono, M; Goto, M

    SEPARATION AND PURIFICATION TECHNOLOGY   331   125619 - 125619   2024年3月   ISSN:1383-5866 eISSN:1873-3794

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Separation and Purification Technology  

    The emergence of the battery society has resulted in an unprecedented strain on the supply of battery metals, such as nickel, cobalt, and manganese. Consequently, there is an urgent need to develop processing technology for low-grade nickel laterite ores, which are abundant in resources but challenging to process using conventional hydrometallurgy. In the present study, a hydrophobic deep eutectic solvent (DES) was employed for the first time to leach and recover battery metals from a nickel laterite ore. The DES, which was prepared by decanoic acid and trialkylmethylammonium chloride, was expected to regulate the coordination environment by limiting water and providing ligands for the target metals to be stabilized in the DES. As intended, this direct laterite leaching by the DES facilitated the selective leaching of battery metals with iron, while suppressing the leaching of magnesium and silicon which are primary impurities in the laterite ore. Furthermore, stripping and scrubbing of the metals from the DES enabled the selective recovery of battery metals from iron and even allowed for the repeated use of the DES for at least four cycles of the leaching. The proposed process offers a pathway to recover the critical battery metals from abundant magnesium-rich nickel laterite ores.

    DOI: 10.1016/j.seppur.2023.125619

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  • Enabling Metal Sustainability with Polymer Inclusion Membranes: A Critical Review

    Fajar, ATN; Goto, M

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   56 ( 1 )   2023年12月   ISSN:0021-9592 eISSN:1881-1299

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/00219592.2022.2153547

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  • Unlocking the Anticancer Potential of Ionic Liquids

    Noor, NM; Elgharbawy, AAM; Moniruzzaman, M; Goto, M

    CHEMBIOENG REVIEWS   11 ( 2 )   231 - 252   2023年12月   ISSN:2196-9744

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ChemBioEng Reviews  

    Despite advances in cancer treatment, many types of cancer still have high mortality rates, and the existing therapies can cause considerable side effects. Therefore, discovering new therapies, especially ones with fewer side effects, is desirable to improve the outcomes for cancer patients. Ionic liquids (ILs) have emerged as potential candidates for cancer treatment because of their particular physicochemical properties, which can be tailored for specific applications. In recent years, interest in exploring the potential of ILs in cancer treatment has been growing, and several studies have demonstrated the effectiveness of ILs in inhibiting cancer-cell growth. This review provides insight into the anticancer potential of ILs, exploring the diverse applications and the underlying mechanisms behind the cytotoxicity toward cancer cells of ILs. Understanding the mechanisms behind the cytotoxicity of ILs can aid in the design and optimization of IL-based cancer therapies. By focusing on specific pathways and targets, IL-based cancer therapies may be developed that offer new possibilities for treating this devastating disease.

    DOI: 10.1002/cben.202300051

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  • Formulation and characterization of choline oleate-based micelles for co-delivery of luteolin, naringenin, and quercetin

    Shimul, IM; Moshikur, RM; Nabila, FH; Moniruzzaman, M; Goto, M

    FOOD CHEMISTRY   429   136911   2023年12月   ISSN:0308-8146 eISSN:1873-7072

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Food Chemistry  

    Flavonoids have diverse beneficial roles that potentiate their application as nutraceutical agents in nutritional supplements and as natural antimicrobial agents in food preservation. To address poor solubility and bioactivity issues, we developed water-soluble micellar formulations loaded with single and multiple flavonoids using the biocompatible surface-active ionic liquid choline oleate. The food preservation performance was investigated using luteolin, naringenin, and quercetin as model bioactive compounds. The micellar formulations formed spherical micelles with particle sizes of <150 nm and exhibited high aqueous solubility (>5.15 mg/mL). Co-delivery of multiple flavonoids (luteolin, naringenin, and quercetin in LNQ-MF) resulted in 84.85% antioxidant activity at 100 μg/mL. The effects on Staphylococcus aureus and Salmonella enterica were synergistic with fractional inhibitory concentration indices of 0.87 and 0.71, respectively. LNQ-MF hindered the growth of S. aureus in milk (0.83–0.89 log scale) compared to the control. Co-delivered encapsulated flavonoids are a promising alternative to chemical preservatives.

    DOI: 10.1016/j.foodchem.2023.136911

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  • Demystifying the phase diagrams of deep eutectic solvents within an extensive chemical space

    Adroit T.N. Fajar, Takafumi Hanada, Aditya D. Hartono, Masahiro Goto

    Communications Chemistry   2023年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21203/rs.3.rs-3338523/v1

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  • Pharmaceutical Applications of Ionic Liquids: A Personal Account

    Moshikur, RM; Goto, M

    CHEMICAL RECORD   23 ( 8 )   e202300026   2023年8月   ISSN:1527-8999 eISSN:1528-0691

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Chemical Record  

    Ionic liquids (ILs) have been extensively used in drug formulation and delivery as designer solvents and other components because of their inherent tunability and useful physicochemical and biopharmaceutical properties. ILs can be used to manage some of the operational and functional challenges of drug delivery, including drug solubility, permeability, formulation instability, and in vivo systemic toxicity, that are associated with conventional organic solvents/agents. Furthermore, ILs have been recognized as potential solvents to address the polymorphism, limited solubility, poor permeability, instability, and low bioavailability of crystalline drugs. In this account, we discuss the technological progress and strategies toward designing biocompatible ILs and explore potential biomedical applications, namely the solubilization of small and macromolecular drugs, the creation of active pharmaceutical ingredients, and the delivery of pharmaceuticals.

    DOI: 10.1002/tcr.202300026

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  • Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids

    Toyofuku K., Wakabayashi R., Kamiya N., Goto M.

    ACS Applied Materials and Interfaces   15 ( 28 )   33299 - 33308   2023年7月   ISSN:19448244 eISSN:1944-8252

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Applied Materials and Interfaces  

    Nucleic acid drugs, including antisense oligonucleotides (ASOs), have received considerable attention as novel therapeutics for the treatment of intractable diseases. Despite their potential benefits, ASOs are currently administered via injection, which can negatively impact patient quality of life because of the prevalence of severe injection site reactions. Non-invasive transdermal administration of ASOs is desirable but highly challenging owing to the strong barrier imposed by the stratum corneum, which only permits the penetration of small molecules under 500 Da. For ASOs to exert their antisense effect, they must traverse the negatively charged cell membrane and reach the cytoplasm. In this study, we used the solid-in-oil (S/O) dispersion technology to facilitate the skin permeation of ASOs by coating the drug with a hydrophobic surfactant molecule, specifically lipid-based ionic liquid (IL) surfactants with high biocompatibility and transdermal penetration-enhancing properties. To induce the antisense effect, it was important to achieve simultaneous transdermal delivery and intracellular entrapment of ASOs. In vitro investigations indicated that the newly prepared IL-S/O enhanced the transdermal penetration and intracellular delivery of ASOs, thus inhibiting mRNA translation of the target TGF-β. In addition, in vivo investigations of tumor-bearing mice suggested that the anti-tumor effect of the IL-S/O was similar to that of injection. This study demonstrates the potential of non-invasive transdermal delivery carriers based on biocompatible ILs, which can be applied to a variety of nucleic acid drugs.

    DOI: 10.1021/acsami.3c03900

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  • Effect of Hydrophobicity of Ionic Liquids on the Leaching Selectivity of Platinum from a Spent Automotive Catalyst 査読 国際誌

    Hanada T., Takaoka S., Kamisono M., Fajar A.T.N., Goto M.

    Solvent Extraction Research and Development, Japan   30 ( 2 )   149 - 157   2023年5月   ISSN:13417215 eISSN:21884765

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本溶媒抽出学会  

    Recycling platinum group metals from secondary resources such as spent automotive exhaust catalysts is promising for the circular economy. However, the selective separation of Pt over massive amounts of impurity metals such as Mg and Al is particularly challenging. In this study, non-aqueous direct leaching of platinum from a spent automotive catalyst (SAC) using hydrophobic ionic liquids, namely, trihexyl(tetradecyl)phosphonium chloride (P66614Cl) and trioctyl(dodecyl)phosphonium chloride (P88812Cl) with the aid of pre-loading hydrochloric acid/hydrogen peroxide was proposed. The more hydrophobic P88812Cl exhibited more efficient and selective leaching of Pt over Mg and Al. The recovery of Pt from the metal-loaded P88812Cl, and the reusability of the IL for SAC leaching were also demonstrated.

    DOI: 10.15261/serdj.30.149

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  • Evaluation of Crude Oil Wax Dissolution Using a Hydrocarbon-Based Solvent in the Presence of Ionic Liquid 査読 国際誌

    Abidin, MRSZ; Noh, MH; Moniruzzaman, M; Goto, M

    PROCESSES   11 ( 4 )   1112   2023年4月   eISSN:2227-9717

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Processes  

    The current alternative of using aromatic-based wax soak solvents has been found to be hazardous and imposes a high cost on field expenditures. These solvents are widely used in the oil and gas industry to soften up wax before the pigging process. However, their impacts on the environment are quite concerning. Plus, they also impose hazardous exposure and are found to be damaging to both plastic and rubber hoses. To replace the current alternative with other hydrocarbon-based wax soak solvents, ionic liquids were found to have the capability to increase the solvent power capabilities and the efficiency of wax soak solvent in dissolving heavy crude oil. To optimise the application of hydrocarbon solvents and ionic liquid in wax dissolution, the affinity of ionic liquids in three solvents was studied. The solvents were condensate, ethyl acetate, and xylene. It was found that from four types of ionic liquids tested, only BMIMCL and HMIMBr were miscible in all three of the solvents used. Dissolution of hard deposited paraffin wax in condensate, ethyl acetate and xylene was conducted using the spectral analysis method, and it was found that the dissolution of paraffin wax was greatest in ethyl acetate. However, enchantment on wax dissolution was also observed for gas condensate and xylene. The wax soaking time was also optimised, in which the dissolution of wax was found to reach a saturation level when the wax had been soaked for over 90 min in the solvents, especially for gas condensate. Further study on the effect of ionic liquid introduced alongside condensate, ethyl acetate and xylene, aiming to enhance the solvent power, was also conducted using the spectral analysis method. The introduction of ionic liquids to all hydrocarbon-based wax soak solvents used in this project was proven to significantly increase the UV-VIS absorbance of the extracted solvents after paraffin wax had been soaked for 30 min.

    DOI: 10.3390/pr11041112

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  • Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine

    SHIHAB UDDIN, Md. Rafiqul Islam, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecules   2023年4月

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    DOI: 10.3390/molecules28072969

  • Ionic Liquid-Based Green Emulsion Liquid Membrane for the Extraction of the Poorly Soluble Drug Ibuprofen 査読 国際誌

    Khan, HW; Elgharbawy, AAM; Bustam, MA; Goto, M; Moniruzzaman, M

    MOLECULES   28 ( 5 )   2345   2023年4月   eISSN:1420-3049

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Molecules  

    Ibuprofen (Ibf) is a biologically active drug (BADs) and an emerging contaminant of concern (CECs) in aqueous streams. Due to its adverse effects upon aquatic organisms and humans, the removal and recovery of Ibf are essential. Usually, conventional solvents are employed for the separation and recovery of ibuprofen. Due to environmental limitations, alternative green extracting agents need to be explored. Ionic liquids (ILs), emerging and greener alternatives, can also serve this purpose. It is essential to explore ILs that are effective for recovering ibuprofen, among millions of ILs. The conductor-like screening model for real solvents (COSMO-RS) is an efficient tool that can be used to screen ILs specifically for ibuprofen extraction. The main objective of this work was to identify the best IL for the extraction of ibuprofen. A total of 152 different cation?anion combinations consisting of eight aromatic and non-aromatic cations and nineteen anions were screened. The evaluation was based upon activity coefficients, capacity, and selectivity values. Furthermore, the effect of alkyl chain length was studied. The results suggest that quaternary ammonium (cation) and sulfate (anion) have better extraction ability for ibuprofen than the other combinations tested. An ionic liquid-based green emulsion liquid membrane (ILGELM) was developed using the selected ionic liquid as the extractant, sunflower oil as the diluent, Span 80 as the surfactant, and NaOH as the stripping agent. Experimental verification was carried out using the ILGELM. The experimental results indicated that the predicted COSMO-RS and the experimental results were in good agreement. The proposed IL-based GELM is highly effective for the removal and recovery of ibuprofen.

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  • Ternary extractant system consisting of PC-88A, TOPO, and Versatic 10 for recovery of scandium(III) from nickel laterite processing liquors 査読 国際誌

    Yoshida, W; Goto, M

    HYDROMETALLURGY   217   106024   2023年4月   ISSN:0304-386X eISSN:1879-1158

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hydrometallurgy  

    Solvent extraction of scandium(III) from an aqueous solution, which simulates a concentrated scandium solution generated from nickel/cobalt mixed-sulfide production process, was performed using a ternary mixed extractant system. Addition of tri-n-octylphosphine oxide and a long-chain alkyl carboxylic acid (Versatic 10) to an organophosphonic ester (PC-88A) drastically improved the separation factor of scandium over zirconium in comparison with that of a single extractant system. The optimum mixing ratio in the ternary extractant system was 10 mol% PC-88A, 60 mol% tri-n-octylphosphine oxide, and 30 mol% Versatic 10. The degree of scandium extraction was 90%, and the separation factors between scandium and other metals (i.e., Al, Fe, Ni, Cr, and Zr) were > 140 at pH 2 with the optimized ternary extractant system. The operating conditions for a countercurrent multistage extraction of scandium were investigated by McCabe?Thiele analysis. Ninety-nine percent recovery from 1800 mg dm?3 scandium was achieved by two- to three-stage countercurrent extraction at the flow ratio (A/O) = 1.01. The stripping efficiency of scandium reached >98% with 7 mol dm?3 H3PO4. Based on the results, a conceptual flowsheet for scandium recovery from waste solutions of laterite ore leachate is proposed.

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  • Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery

    Moshikur, RM; Carrier, RL; Moniruzzaman, M; Goto, M

    PHARMACEUTICS   15 ( 4 )   2023年4月   ISSN:1999-4923 eISSN:1999-4923

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Pharmaceutics  

    The development of effective drug formulations and delivery systems for newly developed or marketed drug molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, and systemic toxicity, and can be difficult to formulate with traditional organic solvents due to acute toxicity. Ionic liquids (ILs) are recognized as solvents that can improve the pharmacokinetic and pharmacodynamic properties of drugs. ILs can address the operational/functional challenges associated with traditional organic solvents. However, many ILs are non-biodegradable and inherently toxic, which is the most significant challenge in developing IL-based drug formulations and delivery systems. Biocompatible ILs comprising biocompatible cations and anions mainly derived from bio-renewable sources are considered a green alternative to both conventional ILs and organic/inorganic solvents. This review covers the technologies and strategies developed to design biocompatible ILs, focusing on the design of biocompatible IL-based drug formulations and delivery systems, and discusses the advantages of these ILs in pharmaceutical and biomedical applications. Furthermore, this review will provide guidance on transitioning to biocompatible ILs rather than commonly used toxic ILs and organic solvents in fields ranging from chemical synthesis to pharmaceutics.

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  • Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine

    Shihab Uddin, Md Rafiqul Islam, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecules   28 ( 7 )   2023年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/molecules28072969

  • Transdermal Transmission Blocking Vaccine for Malaria using a Solid-in-Oil Dispersion 査読 国際誌

    Tanaka, K; Minamihata, K; Wakabayashi, R; Lee, JM; Miyata, T; Kusakabe, T; Kamiya, N; Goto, M

    JOURNAL OF PHARMACEUTICAL SCIENCES   112 ( 2 )   411 - 415   2023年2月   ISSN:0022-3549 eISSN:1520-6017

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Pharmaceutical Sciences  

    Malaria is a mosquito-borne infectious disease that is widespread in developing countries. Malaria vaccines are important in efforts to eradicate malaria; however, vaccines are usually administered by injection, which requires medical personnel and has a risk of causing infection. Transdermal vaccines can be administered without damaging the skin and thus are ideal for the prevention of malaria. However, the stratum corneum forms a "brick and mortar" like structure in which stratum corneum cells are embedded in a hydrophobic matrix composed of lipids, which strongly inhibits the permeation of hydrophilic substances. In the present study, we designed a transdermal vaccine against vivax malaria using a solid-in-oil (S/O) dispersion. The S/O dispersion of a transmission blocking vaccine candidate, Pvs25 from Plasmodium vivax, showed higher skin penetration than that of the aqueous solution. Mice immunized with the S/O dispersion generated antibodies at similar titers as the mice immunized by injection, over the mid- to long-term. These results provide information for the development of transdermally administered malaria vaccines toward the eradication of malaria.

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  • Amino Acid Leaching of Critical Metals from Spent Lithium-Ion Batteries Followed by Selective Recovery of Cobalt Using Aqueous Biphasic System 査読 国際誌

    Cai, CQ; Fajar, ATN; Hanada, T; Wakabayashi, R; Goto, M

    ACS OMEGA   8 ( 3 )   3198 - 3206   2023年1月   ISSN:2470-1343 eISSN:2470-1343

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Omega  

    To reduce the exploitation of mine resources and decrease the harm to the environment caused by urban electronic wastes, the recovery of critical metals in secondary resources is crucial. In this study, we have successfully developed an eco-friendly process to integrate the leaching and separation of cobalt (Co) from a spent lithium-ion battery (LIB) cathode using an amino acid-based aqueous biphasic system (ABS). We, for the first time, demonstrated a simple method for leaching a LIB cathode using only amino acids. In addition, we have investigated the leaching mechanism using the typical cathode active material lithium cobalt oxide (LiCoO2). Then, the Co was selectively extracted by a biphasic system (amino acid?PPG400?H2O). This novel process has an excellent prospect in the field of spent-battery recycling because of its eco-friendly and process-simplified advantages.

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  • Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery 査読 国際誌

    Moshikur, RM; Shimul, IM; Uddin, S; Wakabayashi, R; Moniruzzaman, M; Goto, M

    ACS APPLIED MATERIALS & INTERFACES   14 ( 50 )   55332 - 55341   2022年12月   ISSN:1944-8244 eISSN:1944-8252

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Applied Materials and Interfaces  

    The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability to permeate the skin; formulation with oil media is difficult without adding chemical permeation enhancers or co-solvents. Herein, we synthesized 12 oil-miscible ionic liquid (IL) drugs comprising lidocaine-, imipramine-, and levamisole (Lev)-hydrochloride with fatty acid permeation enhancers, i.e., laurate, oleate, linoleate, and stearate as counterions. A set of in vitro and in vivo studies was performed to investigate the potency and deliverability of the transdermal drug formulations. All of the synthesized compounds were freely miscible with pharmaceutically acceptable solvents/agents (i.e., ethanol, N-methyl pyrrolidone, Tween 20, and isopropyl myristate (IPM)). In vitro permeation studies revealed that the oleate-based Lev formulation had 2.6-fold higher skin permeation capability than the Lev salts and also superior ability compared with the laurate-, linoleate-, and stearate-containing samples. Upon in vivo transdermal administration to mice, the peak plasma concentration, elimination half-life, and area under the plasma concentration curve values of Lev-IL were 4.6-, 2.9-, and 5.4-fold higher, respectively, than those of the Lev salt. Furthermore, in vitro skin irritation and in vivo histological studies have demonstrated that Lev-IL has excellent biocompatibility compared with a conventional ionic liquid-based carrier. The results indicate that oil-miscible IL-based drugs provide a simple and scalable strategy for the design of effective transdermal drug delivery systems.

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  • Choline oleate based micellar system as a new approach for Luteolin formulation: Antioxidant, antimicrobial, and food preservation properties evaluation 査読 国際誌

    Shimul, IM; Moshikur, RM; Minamihata, K; Moniruzzaman, M; Kamiya, N; Goto, M

    JOURNAL OF MOLECULAR LIQUIDS   365   120151   2022年11月   ISSN:0167-7322 eISSN:1873-3166

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Liquids  

    Luteolin (LUT), an important flavonoid, shows excellent antioxidant and antimicrobial properties. However, its low solubility and stability in water, as well as challenges related to its formulation, have limited its use in food preservation. Here, we develop a highly water-soluble LUT-loaded micellar formulation (LUT-MF) using a solid-in-water nanodispersion technique involving emulsification and lyophilization processes. LUT solubilized in an organic phase comprising acetone, methanol, and cyclohexane (5:10:85 v/v) was emulsified with an aqueous solution of a surface-active ionic liquid, choline oleate ([Cho][Ole]), and the oil in water emulsion was lyophilized to remove the organic phase and water and obtain a solid LUT-[Cho][Ole] complex. LUT-[Cho][Ole] complex was dispersed again in water to prepare the LUT-MF formulation with good stability. Dynamic light scattering and transmission electron microscopy confirmed that the LUT-MF formed spherical micelles with a mean particle size of approximately 73 nm. LUT-MF showed excellent encapsulation efficiency (94.3%) and enhanced aqueous solubility. An in vitro release study in PBS containing 30% ethanol demonstrated 3.94 times higher release of LUT from LUT-MF than from LUT suspension after 24 h. The developed formulation showed better antioxidant activity than both free LUT and ascorbic acid. LUT-MF demonstrated higher antibacterial activity than sodium benzoate. Food preservation studies revealed that treating strawberries with LUT-MF effectively preserved color and prevented shriveling and decay over 8 days storage at 10 °C, compared with sodium benzoate treatment. The results suggest that LUT-MF is a potential natural preservative alternative to conventional toxic chemical preservatives used in the food industry.

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  • Selective recovery of gold from discarded cell phones by silk fibroin from Bombyx mori

    Maghfirah, A; Minamihata, K; Hanada, T; Fajar, ATN; Goto, M

    BIOCHEMICAL ENGINEERING JOURNAL   188   108690 - 108690   2022年10月   ISSN:1369-703X eISSN:1873-295X

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biochemical Engineering Journal  

    Selectivity is a crucial factor for gold recovery from discarded cell phones. This is because discarded cell phones contain a large variety of metals. The use of biomaterials as gold adsorbents is attracting much attention because it is in accordance with sustainability goals. Here, we reported selective adsorption of gold on silk fibroin and its application to gold recovery from the actual leachate of discarded cell phones in a chloride medium. The experimental maximum gold-adsorption capacity of silk fibroin was 5.800 mg/g. Based on a kinetic study, the gold-adsorption mechanism followed the pseudo-second-order model with a rate constant (k2) of 0.077 g mg−1min−1. The adsorption fitted well with the Langmuir model, suggesting a monolayer adsorption mechanism. Despite the small adsorption capacity, silk fibroin showed remarkable selectivity toward gold in synthetic and actual leachate containing Pt4+, Pd2+, Al3+, Cu2+, Ni2+, Zn2+, Pb2+, and Fe3+ metal ions in 0.5 mol/L HCl. The gold uptake from the actual leachate of discarded cell phones was approximately 95 %. The gold loaded on the silk fibroin was completely desorbed by 0.1 mol/L thiourea.

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  • Ionic Liquids Curated by Machine Learning for Metal Extraction

    Fajar, ATN; Hartono, AD; Moshikur, RM; Goto, M

    ACS SUSTAINABLE CHEMISTRY & ENGINEERING   10 ( 38 )   12698 - 12705   2022年9月   ISSN:2168-0485

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Sustainable Chemistry and Engineering  

    Metals are key components of modern devices; however, available resources of these metals are limited. In this study, we used machine learning (ML) to curate ionic liquids (ILs) that are suitable for metal extraction. We proposed classification and regression models to unravel hidden patterns between IL structures and their specific properties, i.e., metal selectivity and eco-toxicity. Evaluations of ML models using cross-validation indicate that the models were reliable, as described by the accuracy score (0.82) and R2value (0.76). The models also revealed that the metal selectivity of ILs was determined by the cation and anion structures, and the eco-toxicity level was primarily affected by the cation structures. Guided by predictions from the trained models, we selected three ILs (out of the 150 IL structures we initially proposed) that have extraction selectivity toward platinum, lithium, and neodymium as well as low eco-toxicity. We then prepared the ILs in the laboratory and assessed their performance by standard solvent extraction. The experiments indicate that the recommended ILs from ML could selectively extract the targeted metals with high extraction efficiency (>80%), which demonstrates the feasibility of ML as a promising toolkit that can help accelerate innovations in metal extraction.

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  • Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy 査読 国際誌

    Uddin, S; Islam, MR; Moshikur, RM; Wakabayashi, R; Kamiya, N; Moniruzzaman, M; Goto, M

    ACS APPLIED BIO MATERIALS   5 ( 6 )   2586 - 2597   2022年5月   ISSN:2576-6422 eISSN:2576-6422

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Applied Bio Materials  

    enhanced, and the transdermal distribution and transdermal flux of the OVA delivery system were 25 and 28 times greater, respectively, than those of its aqueous formulation. The PCNC disrupted the order of lipid orientation in the skin’s SC and increased intercellular protein delivery. It demonstrated effective antitumor activity, drastically (p < 0.001) suppressed tumor growth, increased mouse survival rates, and significantly (p < 0.001) stimulated the OVA-specific tumor immune response. The PCNC also increased the number of cytotoxic T cells expressing CD8 antibodies on their surfaces (CD8 + T-cells) in the tumor microenvironment. These findings suggest that PCNCs may be promising biocompatible carriers for transdermal antigenic protein delivery in tumor immunotherapy.

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  • Cathode recycling of lithium-ion batteries based on reusable hydrophobic eutectic solvents 査読 国際誌

    Hanada, T; Goto, M

    GREEN CHEMISTRY   24 ( 13 )   5107 - 5115   2022年5月   ISSN:1463-9262 eISSN:1463-9270

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Green Chemistry  

    Expansion of the global market for electric vehicles has brought about a significant increase in the demand for the critical metals necessary for lithium-ion battery cathodes. Conventional cathode recycling processes can be detrimentally impactful to the environment because of the high-temperature treatment needed, and the hazardous inorganic acids and organic solvents used. Here, we demonstrate a novel cathode recycling process that employs hydrophobic eutectic solvents (HESs), which have recently attracted interest as green solvents. Our proposed process operates at mild temperatures and uses a reusable HES as an alternative to the aforementioned hazardous acids and solvents. This process consists of two simple steps, starting with direct leaching of the cathode materials by HESs typically composed of synergistic metal ligands, such as a diketone and an alkyl phosphine oxide, after which the leached critical metal ions are then separated and recovered into an aqueous oxalic acid solution. Under the optimal conditions, more than 90% of lithium, cobalt, and other critical metals was leached out from the various cathode materials, aided by ascorbic acid as the natural reducing agent. Subsequently, the metals were quantitatively recovered from the HES into the stripping solution as the cobalt oxalate precipitation and lithium-rich solution. We have succeeded in developing a potentially environmentally harmonious recycling process suitable for the sustainable production of rechargeable batteries.

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  • Novel Ionic Liquid-Based Aqueous Biphasic System with Amino Acids for Critical Metal Recovery from Lithium-Ion Batteries

    Cai, CQ; Hanada, T; Fajar, ATN; Goto, M

    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH   61 ( 15 )   5306 - 5313   2022年4月   ISSN:0888-5885 eISSN:1520-5045

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Industrial and Engineering Chemistry Research  

    The era of electric vehicles is rapidly approaching, and therefore, it is crucial to provide a sustainable technology for ensuring the circular economy of lithium-ion batteries. In this study, we report the development of a novel aqueous biphasic system (ABS) comprising fully biocompatible components, that is, hydrophilic ionic liquids, amino acids, and organic acids, for the selective recovery of Co(II) and Ni(II) from Mn(II), which are critical metals in spent lithium-ion batteries. Separation of Co(II), Ni(II), and Mn(II) from sulfate media was successfully carried out using the ABS in a quite straightforward manner without any hazardous reagents or organic solvents. In addition, the plausible mechanism of metal ion separation within the ABS was elucidated. The regenerated ionic liquid in the ABS exhibited remarkably stable performance during use in three consecutive experimental cycles.

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  • A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect

    Tahara, Y; Mizuno, R; Nishimura, T; Mukai, SA; Wakabayashi, R; Kamiya, N; Akiyoshi, K; Goto, M

    BIOMATERIALS   282   121385 - 121385   2022年3月   ISSN:0142-9612 eISSN:1878-5905

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials  

    The biomaterial-based immunoengineering has become one of the most attractive research fields in the last decade. In the present study, a solid-in-oil-in-water (S/O/W) emulsion encapsulating antigen in the oil phase of an oil-in-water (O/W) emulsion was prepared as a novel vaccine carrier consisting of similar materials to the emulsion adjuvant of which the safety, immunogenicity and vaccination efficacy have been already confirmed in human. Direct observation by high-resolution confocal laser scanning microscopy and small angle X-ray scattering analysis showed that the antigens were dispersed inside of the oil phase of the S/O/W emulsion as solid-state particles. The S/O/W emulsion robustly produced antigen-specific antibodies and enhanced the antitumor effects in a therapeutic cancer vaccination compared with free antigens or the O/W emulsion in vivo. This result is in good agreement with the activation effect of antigen-specific cytotoxic T lymphocytes and antigen presentation by the S/O/W emulsion, indicating that the S/O/W emulsion consisting of already approved materials is a promising vaccine carrier to produce both humoral and cellular immunity.

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  • Amino Acid Ester based Phenolic Ionic Liquids as a Potential Solvent for the Bioactive Compound Luteolin: Synthesis, Characterization, and Food Preservation Activity 査読 国際誌

    Shimul, IM; Moshikur, RM; Minamihata, K; Moniruzzaman, M; Kamiya, N; Goto, M

    JOURNAL OF MOLECULAR LIQUIDS   349   118103   2022年3月   ISSN:0167-7322 eISSN:1873-3166

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Liquids  

    Ionic liquids (ILs) have gained great attention as potent solubilizing agents of poorly soluble bioactive compounds. The use of Luteolin (LUT) – a natural bioactive compound – is limited because of its poor aqueous solubility. To address this issue, this study reports potential ILs for effectively solubilizing LUT at ambient temperature. First, promising ILs were screened from a potential 180 ILs that were proposed by the combination of 20 standard amino acid ethyl esters cations and nine phenolic acids anions using the conductor-like screening model for real solvents (COSMO-RS); the activity coefficients of LUT at infinite dilution in ILs were used as the screening criteria. Four proline ethyl ester phenolate ILs (PEEP-ILs) composed of a biocompatible proline ethyl ester and bioactive phenolic acids (trans-ferulic, vanillic, p-coumaric, and 4-hydroxybenzoic acid) were selected and synthesized. The synthesized PEEP-ILs were characterized through 1H NMR, FT-IR, elemental analysis, TGA, and DSC. The experimental solubility of LUT in PEEP-ILs (60% IL in water) showed excellent solubility. Among the PEEP-ILs, proline ethyl ester ferulate (IL[ProEt][Fer]) exhibited the best LUT solubility, followed by ILs with p-coumarate (IL[ProEt][Cou]), vanillate (IL[ProEt][Van]), and 4-hydroxybenzoate (IL[ProEt][Ben]). 1H NMR assessment and COSMO-RS prediction confirmed that the ILs facilitated the solubilization of LUT through multiple hydrogen bonding, π − π, and cation − π interactions between the LUT and the ILs. The biocompatibility study revealed that PEEP-ILs were relatively harmless and low toxicity compared with conventional imidazolium, pyridinium, pyrrolidinium, piperidinium, and morpholinium-based ILs. The LUT dissolved in the newly-synthesized PEEP-ILs and demonstrated better organoleptic properties on red apple slices. These results indicate that PEEP-ILs can be potential green alternatives to conventional toxic solvents for dissolving poorly water-soluble bioactive natural preservatives.

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  • DFT-Based investigation of Amic-Acid extractants and their application to the recovery of Ni and Co from spent automotive Lithium-Ion batteries 国際誌

    Hanada, T; Seo, K; Yoshida, W; Fajar, ATN; Goto, M

    SEPARATION AND PURIFICATION TECHNOLOGY   281   119898   2022年1月   ISSN:1383-5866 eISSN:1873-3794

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Separation and Purification Technology  

    To establish more efficient and environmentally friendly lithium-ion battery (LiB) recycling processes, novel extractants derived from amino acids that enable better separation of Ni and Co were explored using density functional theory (DFT) calculations. DFT calculations and experimental validation indicated that of the three coordination sites-namely amine, amide, and carboxyl groups in the amic-acid ligands-the bond strength of the central amine group to the metal determines the Ni and Co separation performance. Based on the findings, the glycine-derived amic-acid extractant N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]glycine (D2EHAG) was applied for the recovery of Ni and Co from a spent automotive LiB leachate. Preferential and mutual recovery of Ni and Co from manganese by the D2EHAG-based recycling process was demonstrated. This study provides insights into the design of extractants that enable the mutual separation of Ni, Co, and Mn, and indicates the suitability of amic-acid extractants for LiB recycling processes.

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  • Lyotropic liquid crystal-based transcutaneous peptide delivery system: Evaluation of skin permeability and potential for transcutaneous vaccination

    Kozaka, S; Wakabayashi, R; Kamiya, N; Goto, M

    ACTA BIOMATERIALIA   138   273 - 284   2022年1月   ISSN:1742-7061 eISSN:1878-7568

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Acta Biomaterialia  

    Transcutaneous drug delivery is a promising method in terms of drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, a number of techniques, such as microemulsion, solid-in-oil dispersions and liposomes, have been studied extensively. However, the low viscosity of these formulations limits drug retention on the skin and reduces patient acceptability. Although viscosity can be increased by adding a thickening reagent, such an addition often alters formulation nanostructures and drug solubility, and importantly, decreases skin permeability. In this study, a gel-like lyotropic liquid crystal (LLC) was used as a tool to enhance skin permeability. In particular, we prepared 1-monolinolein (ML)-based LLCs with different water contents. All LLCs significantly enhanced skin permeation of a peptide drug, an epitope peptide of melanoma, despite their high viscoelasticity. Fourier transform infra-red spectroscopic analysis of the skin surface treated with the LLCs revealed that the gyroid geometry more strongly interacted with the lamellar structure inside the stratum corneum (SC) than the diamond geometry. Finally, as the result of the in vivo tumor challenge experiment using B16F10 melanoma-bearing mice, the LLC with the gyroid geometry showed stronger vaccine effect against tumor than a subcutaneous injection. Collectively, ML-based LLCs, especially with the gyroid geometry, are a promising strategy to deliver biomacromolecules into skin. Statement of significance: Transcutaneous drug delivery is a promising method for drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, we used a gel-like lyotropic liquid crystal (LLC) as a novel tool to enhance skin permeability. In this paper, we demonstrated that an LLC with a specific liquid crystalline structure has the highest skin permeation enhancement effect for a peptide antigen as a model drug. Moreover, the peptide antigen-loaded LLC showed a vaccine effect that was comparable to a subcutaneous injection in vivo. This study provides a basis for designing a transcutaneous delivery system of peptide drugs with LLC.

    DOI: 10.1016/j.actbio.2021.11.008

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  • Amino Acid Ester based Phenolic Ionic Liquids as a Potential Solvent for the Bioactive Compound Luteolin: Synthesis, Characterization, and Food Preservation Activity 招待 査読 国際誌

    #Islam Md Shimul, @Rahman Md Moshikur, @Kosuke Minamihata, @Muhammad Moniruzzaman, @Noriho Kamiya, @Masahiro Goto

    Journal of Molecular Liquids   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.1016/j.molliq.2021.118103

  • Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion 招待 査読 国際誌

    Md Rafiqul Islam, Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Materials and Interfaces   13 ( 36 )   42461 - 42472   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsami.1c11533

  • Favipiravir-Based Ionic Liquids as Potent Antiviral Drugs for Oral Delivery: Synthesis, Solubility, and Pharmacokinetic Evaluation 招待 査読 国際誌

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecular Pharmaceutics   18 ( 8 )   3108 - 3115   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.1c00324

  • Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug 招待 査読 国際誌

    Shihab Uddin, Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Bio Materials   4 ( 8 )   6256 - 6267   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.1c00563

  • Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel. 国際誌

    Md Korban Ali, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS applied materials & interfaces   13 ( 17 )   19745 - 19755   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsami.1c03111

  • Biocompatible ionic liquids assisted transdermal co-delivery of antigenic protein and adjuvant for cancer immunotherapy. 国際誌

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    International journal of pharmaceutics   601   120582 - 120582   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2021.120582

  • Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation 招待 査読 国際誌

    #YuyaHirakawa, @Hiroshi Ueda, @Yusuke Takata, @Kosuke Minamihata ,@Rie Wakabayashi, @Noriho Kamiya, @Masahiro Goto

    European Journal of Pharmaceutical Sciences   158   105667   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.1016/j.ejps.2020.105667

  • Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation. 国際誌

    Yuya Hirakawa, Hiroshi Ueda, Yusuke Takata, Kosuke Minamihata, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences   158   105667 - 105667   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejps.2020.105667

  • Solid-in-oil nanodispersions as a novel delivery system to improve the oral bioavailability of bisphosphate, risedronate sodium 査読 国際誌

    Y. Hou, H. Piao, Y. Tahara, S. Qin, J. Wang, Q. Kong, M. Zou, G. Cheng, M. Goto

    European Journal of Pharmaceutical Sciences   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1016/j.ejps.2020.105521

  • Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant 査読 国際誌

    R. Md Moshikur, Md. K. Ali, R. Wakabayashi, M. Moniruzzaman, M. Goto,

    Journal of Molecular Liquids   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1016/j.molliq.2020.114424

  • Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation 査読 国際誌

    S. Uddin, Md. R. Chowdhury, R. Wakabayashi, N. Kamiya, M. Moniruzzaman, M. Goto

    Chem. Comm   13756 - 13759   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1039/d0cc04491a

  • Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect 招待 査読 国際誌

    Yoshiro Tahara, Kaho Morita, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.0c00598

  • An environmentally benign ionic liquid based formulation for enhanced oil spill remediation: Optimization of environmental factors 査読 国際誌

    M. U. H. Shah, M. Moniruzzaman, V. B. R. Ambavaram, R. T. M. Mahabubur, Dr S. Yusup, M. Goto

    Journal of Molecular Liquids   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1016/j.molliq.2020.113603

  • Liquid–Liquid Extraction of Cd(II) and Zn(II) Using Novel Tetraalkylphosphonium Ionic Liquid 査読 国際誌

    2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Effective transcutaneous delivery of hyaluronic acid using an easy-to-prepare reverse micelle formulation 招待 査読 国際誌

    Shuto Kozaka, Ayaka Kashima, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Masahiro Goto

    Cosmetics   7 ( 3 )   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/COSMETICS7030052

  • Monoolein Assisted Oil-Based Transdermal Delivery of Powder Vaccine 査読 国際誌

    M. Kitaoka, A. Oka, M. Goto

    Pharmaceutics   814 - 826   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.3390/pharmaceutics12090814

  • Design and Characterization of Fatty Acid Based Amino Acid Ester as a new “Green” Hydrophobic Ionic Liquid for Drug Delivery 査読 国際誌

    2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://dx.doi.org/10.1021/acssuschemeng.0c03419

  • Selective separation of platinum group metals via sequential transport through polymer inclusion membranes containing an ionic liquid carrier 査読 国際誌

    A. T. N. Fajar, T. Hanada, M. L. Firmansyah, F. Kubota, M. Goto

    ACS Sustainable Chemistry & Engineering   11283 - 11291   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1021/acssuschemeng.0c03205

  • Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir 査読

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   582   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2020.119335

  • Transport of Rhodium(III) from Chloride Media across a Polymer Inclusion Membrane Containing an Ionic Liquid Metal Ion Carrier 招待 査読 国際誌

    T. Hanada, M. L. Firmansyah, W. Yoshida, F. Kubota, S. D. Kolev, M. Goto

    ACS Omega   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://dx.doi.org/10.1021/acsomega.0c00867

  • Ionic liquid-in-oil microemulsions prepared with biocompatible choline carboxylic acids for improving the transdermal delivery of a sparingly soluble drug 査読

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Pharmaceutics   12 ( 4 )   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/pharmaceutics12040392

  • Biocompatible Ionic Liquid Surfactant Based Microemulsion as a Potential Carrier for Sparingly Soluble Drugs 査読 国際誌

    22. M.K. Ali, R.M. Moshikur, R. Wakabayashi, M. Moniruzzaman, N. Kamiya, M. Goto

    ACS Sustainable Chemistry & Engineering   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1021/acssuschemeng.9b07773

  • A solid-in-oil nanodispersion system for transcutaneous immunotherapy of cow’s milk allergies 査読 国際誌

    12 ( 3 )   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    An allergy to cow’s milk proteins is the most common food allergy in infants and toddlers. Conventional oral immunotherapy for cow’s milk allergies requires hospital admission due to the risk of severe allergic reactions, including anaphylaxis. Therefore, a simpler and safer immunotherapeutic method is desirable. We examined transcutaneous immunotherapy with a solid-in-oil (S/O) system. In the S/O system, nano-sized particles of proteins are dispersed in an oil-vehicle with the assistance of nonionic surfactants. In the present study, the S/O system enhanced the skin permeation of the allergen molecule β-lactoglobulin (BLG), as compared with a control PBS solution. The patches containing BLG in the S/O nanodispersion skewed the immune response in the allergy model mice toward T helper type 1 immunity, indicating the amelioration of allergic symptoms. This effect was more pronounced when the immunomodulator resiquimod (R-848) was included in the S/O system.

    DOI: 10.3390/pharmaceutics12030205

  • Solid-in-oil nanodispersions for transcutaneous immunotherapy of Japanese cedar pollinosis 招待 査読 国際誌

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   12 ( 3 )   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/pharmaceutics12030240

  • Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery Synthesis, characterization, and skin-penetration evaluation 査読 国際誌

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   299   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2019.112166

  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier 査読 国際誌

    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 2 )   645 - 655   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.9b01104

  • Recent advances of enzymatic reactions in ionic liquids Part II 査読 国際誌

    Amal A.M. Elgharbawy, Muhammad Moniruzzaman, Masahiro Goto

    Biochemical Engineering Journal   154   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2019.107426

  • Separation and Recovery of Scandium from Sulfate Media by Solvent Extraction and Polymer Inclusion Membranes with Amic Acid Extractants 査読 国際誌

    Wataru Yoshida, Fukiko Kubota, Yuzo Baba, Spas D. Kolev, Masahiro Goto

    ACS Omega   4 ( 25 )   21122 - 21130   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsomega.9b02540

  • Separation of Pallaium(II) an Rhoium(III) Using a Polymer Inclusion Membrane Containing a Phosphonium-Base Ionic Liqui Carrier 査読 国際誌

    Aroit T.N. Fajar, Fukiko Kubota, Mochama L. Firmansyah, Masahiro Goto

    Industrial and Engineering Chemistry Research   58 ( 49 )   22334 - 22342   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.iecr.9b05183

  • Solid-in-oil nanodispersions for intranasal vaccination Enhancement of mucosal and systemic immune responses 査読 国際誌

    Qingliang Kong, Momoko Kitaoka, Yoshiro Tahara, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   572   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2019.118777

  • Transcutaneous delivery of immunomodulating pollen extract-galactomannan conjugate by solid-in-oil nanodispersions for pollinosis immunotherapy 査読 国際誌

    Qingliang Kong, Kouki Higasijima, Rie Wakabayashi, Yoshiro Tahara, Momoko Kitaoka, Hiroki Obayashi, Yanting Hou, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   11 ( 11 )   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/pharmaceutics11110563

  • Synthesis and characterization of choline–fatty-acid-based ionic liquids A new biocompatible surfactant 査読

    551   72 - 80   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ionic liquid (IL)surfactants have attracted great interest as promising substitutes for conventional surfactants owing to their exceptional and favorable physico-chemical properties. However, most IL surfactants are not eco-friendly and form unstable micelles, even when using a high concentration of the surfactant. In this study, we prepared a series of halogen-free and biocompatible choline–fatty-acid-based ILs with different chain lengths and degrees of saturation, and we then investigated their micellar properties in aqueous solutions. Characterization of the synthesized surface-active ILs (SAILs)was performed by
    H and C nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and elemental analysis. The surface-active properties of the SAILs were investigated by tensiometry, conductometry, and dynamic light scattering measurements. The critical micelle concentration of the SAILs was found to be 2–4 times lower than those of conventional surfactants. The thermodynamic properties of micellization (ΔG 0m, ΔH 0m, and ΔS 0m)indicate that the micellization process of the SAILs is spontaneous, stable, and entropy-driven at room temperature. The cytotoxicity of the SAILs was evaluated using mammalian cell line NIH 3T3. Importantly, [Cho][Ole]shows lower toxicity than the analogous ILs with conventional surfactants. These results clearly suggest that these environmentally friendly SAILs can be used as a potential alternative to conventional ILs for various purposes, including biological applications.

    DOI: 10.1016/j.jcis.2019.04.095

  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations 査読

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   565   219 - 226   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2019.05.020

  • A binary mixture of a biosurfactant and an ionic liquid surfactant as a green dispersant for oil spill remediation 査読

    Mansoor Ul Hassan Shah, Muhammad Moniruzzaman, Magaret Sivapragasam, Md Mahabubur Rahman Talukder, Suzana Bt Yusup, Masahiro Goto

    Journal of Molecular Liquids   280   111 - 119   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2019.02.049

  • Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance 査読

    Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Yoshiro Tahara, Keisuke Fujii, Isao Tawara, Yoshihiro Miyahara, Kana Okamori, Hideo Yagita, Seiya Imoto, Rui Yamaguchi, Mitsuhiro Komura, Satoru Miyano, Masahiro Goto, Shin Ichi Sawada, Akira Asai, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada, Hiroshi Shiku

    Journal of Clinical Investigation   129 ( 3 )   1278 - 1294   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1172/JCI97642

  • Ionic liquids with methotrexate moieties as a potential anticancer prodrug Synthesis, characterization and solubility evaluation 査読

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   278   226 - 233   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2019.01.063

  • Application of a Novel Phosphonium-Based Ionic Liquid to the Separation of Platinum Group Metals from Automobile Catalyst Leach Liquor 査読

    Mochamad L. Firmansyah, Fukiko Kubota, Wataru Yoshida, Masahiro Goto

    Industrial and Engineering Chemistry Research   58 ( 9 )   3845 - 3852   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.iecr.8b05848

  • Selective transport of scandium(III) across polymer inclusion membranes with improved stability which contain an amic acid carrier 査読

    Wataru Yoshida, Yuzo Baba, Fukiko Kubota, Spas D. Kolev, Masahiro Goto

    Journal of Membrane Science   291 - 299   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.memsci.2018.11.021

  • Selective separation and recovery of Pt(IV) from Pd(II) through an imidazolium-ionic-liquid-based supported liquid membrane 査読

    Wataru Yoshida, Fukiko Kubota, Riho Kono, Masahiro Goto

    analytical sciences   35 ( 3 )   343 - 346   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.18N020

  • Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control 査読

    Rie Wakabayashi, Ayumi Suehiro, Masahiro Goto, Noriho Kamiya

    Chemical Communications   55 ( 5 )   640 - 643   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/C8CC08163H

  • A novel binary-extractant-impregnated resin for selective recovery of scandium 査読

    Maha Sharaf, Wataru Yoshida, Fukiko Kubota, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   49 - 55   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.18we175

  • Transcutaneous codelivery of tumor antigen and resiquimod in solid-in-oil nanodispersions promotes antitumor immunity 査読

    Rie Wakabayashi, Hidetoshi Kono, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    ACS Biomaterials Science and Engineering   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.9b00260

  • Liquid Marbles as an Easy-to-Handle Compartment for Cell-Free Synthesis and In Situ Immobilization of Recombinant Proteins 査読

    Noriho Kamiya, Yuki Ohama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto

    Biotechnology Journal   13 ( 12 )   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201800085

  • Selective Extraction of Scandium by a Long Alkyl Chain Carboxylic Acid/Organophosphonic Ester Binary Extractant 査読

    Maha Sharaf, Wataru Yoshida, Fukiko Kubota, Masahiro Goto

    Solvent Extraction and Ion Exchange   36 ( 7 )   647 - 657   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/07366299.2018.1532139

  • Aggregation behavior and antimicrobial activity of a micellar system of binary ionic liquids 査読

    Mansoor Ul Hassan Shah, Magaret Sivapragasam, Muhammad Moniruzzaman, Md Mahabubur Rahman Talukder, Suzana Bt Yusup, Masahiro Goto

    Journal of Molecular Liquids   266   568 - 576   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2018.06.101

  • Ionic-Liquid-Based Paclitaxel Preparation A New Potential Formulation for Cancer Treatment 査読

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Molecular pharmaceutics   15 ( 6 )   2484 - 2488   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.8b00305

  • Solvent extraction of Pt(IV), Pd(II), and Rh(III) with the ionic liquid trioctyl(dodecyl) phosphonium chloride 査読 国際誌

    Mochamad L. Firmansyah, Fukiko Kubota, Masahiro Goto

    Journal of Chemical Technology and Biotechnology   93 ( 6 )   1714 - 1721   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jctb.5544

  • Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids 査読 国際誌

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   546 ( 1-2 )   31 - 38   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2018.05.021

  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma 査読 国際誌

    Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Molecular Pharmaceutics   15 ( 3 )   955 - 961   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.7b00894

  • Genipin-stabilized caseinatehitosan nanoparticles for enhanced stability and anti-cancer activity of curcumin 査読 国際誌

    Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya

    Colloids and Surfaces B: Biointerfaces   164   308 - 315   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2018.01.041

  • Mechanistic investigation of transcutaneous protein delivery using solid-in-oil nanodispersion A case study with phycocyanin 査読 国際誌

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Momoko Kitaoka, Yoshiro Tahara, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    European Journal of Pharmaceutics and Biopharmaceutics   127   44 - 50   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejpb.2018.01.020

  • A polymer inclusion membrane composed of the binary carrier PC-88A and Versatic 10 for the selective separation and recovery of Sc 査読 国際誌

    Maha Sharaf, Wataru Yoshida, Fukiko Kubota, Spas D. Kolev, Masahiro Goto

    RSC Advances   8 ( 16 )   8631 - 8637   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c7ra12697b

  • Recent advances of ionic liquids for transdermal drug delivery systems 査読

    Yoshiro Tahara, Masahiro Goto

    Drug Delivery System   33 ( 4 )   303 - 310   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2745/dds.33.303

  • Extraction of rhodium by liquid surfactant membranes containing ionic liquid as a carrier from hydrochloric acid solutions 査読

    Takahiko Kakoi, Kanako Muranaga, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   51 ( 11 )   917 - 920   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.18we086

  • Recovery of gold ions from discarded mobile phone leachate by solvent extraction and polymer inclusion membrane (PIM) based separation using an amic acid extractant 招待 査読 国際誌

    Fukiko Kubota, Riho Kono, Wataru Yoshida, Maha Sharaf, Spas D. Kolev, Masahiro Goto

    Separation and Purification Technology   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.seppur.2018.04.031

  • Ionic Liquid Based Nanocarriers for Topical and Transdermal Drug Delivery 招待 査読 国際誌

    M. Moniruzzaman, H. Mahmood, Masahiro Goto

    Ionic Liquid Devices   390 - 403   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/9781788011839-00390

  • Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase 査読 国際誌

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   28 ( 12 )   2954 - 2961   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.bioconjchem.7b00594

  • Related topic Solid-in-oil technique to increase skin permeation 招待 査読 国際誌

    Momoko Kitaoka, Masahiro Goto

    Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds   225 - 232   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/978-4-431-56526-0_18

  • Solubility of acyclovir in nontoxic and biodegradable ionic liquids COSMO-RS prediction and experimental verification 査読 国際誌

    Meysam Lotfi, Muhammad Moniruzzaman, Magaret Sivapragasam, Shalini Kandasamy, M. I. Abdul Mutalib, Noorjahan Banu Alitheen, Masahiro Goto

    Journal of Molecular Liquids   243   124 - 131   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2017.08.020

  • Transcutaneous immunotherapy of pollinosis using solid-in-oil nanodispersions loaded with T cell epitope peptides 査読 国際誌

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   529 ( 1-2 )   401 - 409   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2017.07.020

  • Separation of Cobalt by Solvent Extraction Using Oxide-Amine Mixture System 査読 国際誌

    M. Takano, Y. Ozaki, S. Asano, Y. Baba, F. Kubota, M. Goto

    J. MMIJ.   136 ( 8 )   188 - 192   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction and stripping behavior of platinum group metals using an amic-acid-type extractant 査読 国際誌

    Wataru Yoshida, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Journal of Chemical Engineering of Japan   50 ( 7 )   521 - 526   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.16we335

  • Extraction and separation of Pt and Pd by an imidazolium-based ionic liquid combined with phosphonium chloride 査読 国際誌

    Fukiko Kubota, Eiko Shigyo, Wataru Yoshida, Masahiro Goto

    Solvent Extraction Research and Development   24 ( 2 )   97 - 104   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.24.97

  • Transcutaneous pollinosis immunotherapy using a solid-in-oil nanodispersion system carrying T cell epitope peptide and R848 招待 査読 国際誌

    Momoko Kitaoka, Masahiro Goto

    Bioengineering & Translational Medicine   2 ( 1 )   102 - 108   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/btm2.10048

  • Transdermal protein delivery and immunization by a solid-in-oil nanodispersion technique 査読

    Yoshiro Tahara, Masahiro Goto

    Drug Delivery System   32 ( 3 )   176 - 183   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2745/dds.32.176

  • Production of sophorolipids by Starmerella bombicola yeast using new hydrophobic substrates 査読 国際誌

    Mansoor Ul Hassan Shah, Magaret Sivapragasam, Muhammad Moniruzzaman, Md Mahabubur Rahman Talukder, Suzana Bt Yusup, Masahiro Goto

    Biochemical Engineering Journal   127   60 - 67   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2017.08.005

  • Evolution of heterogeneity accompanying sol-gel transitions in a supramolecular hydrogel 査読 国際誌

    Yuji Matsumoto, Atsuomi Shundo, Masashi Ohno, Nobutomo Tsuruzoe, Masahiro Goto, Keiji Tanaka

    Soft Matter   13 ( 40 )   7433 - 7440   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c7sm01612c

  • Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay 査読 国際誌

    Rie Wakabayashi, Kensuke Yahiro, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    Biomacromolecules   18 ( 2 )   422 - 430   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01538

  • Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process 査読 国際誌

    Norasikin Othman, Norul Fatiha Mohamed Noah, Lim Yin Shu, Zing Yi Ooi, Norela Jusoh, Mariani Idroas, Masahiro Goto

    Chinese Journal of Chemical Engineering   25 ( 1 )   45 - 52   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cjche.2016.06.002

  • Liquid-liquid extraction of enzymatically synthesized functional RNA oligonucleotides using reverse micelles with a DNA-surfactant 招待 査読 国際誌

    Tatsuo Maruyama, Masahiro Goto

    CHEMICAL COMMUNICATIONS   52 ( 83 )   12376 - 12379   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c6cc06985a

  • Solid-in-oil nanodispersions for transdermal drug delivery systems 招待 査読 国際誌

    Momoko Kitaoka, Rie Wakabayashi, Norah Kamiya, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1375 - 1385   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201600081

  • Development of novel adsorbent bearing aminocarbonylmethylglycine and its application to scandium separation 招待 査読 国際誌

    Zhigang Zhao, F. Kubota, Masahiro Goto

    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY   91 ( 11 )   2779 - 2784   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jctb.4884

  • Analysis of Multiple Solvation Interactions of Methotrexate and Ammonium Based Ionic Liquids Using COSMO-RS 招待 査読 国際誌

    Lotfi, Meysam, Moniruzzaman, Muhammad, Masahiro Goto

    PROCEEDING OF 4TH INTERNATIONAL CONFERENCE ON PROCESS ENGINEERING AND ADVANCED MATERIALS (ICPEAM 2016)   148   459 - 466   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.proeng.2016.06.464

  • Ionic liquids as a potential tool for drug delivery systems 招待 査読 国際誌

    Adawiyah, Noorul, Moniruzzaman, Muhammad, Masahiro Goto

    MEDCHEMCOMM   7 ( 10 )   1881 - 1897   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c6md00358c

  • Diglycolic amic acid-modified E. coli as a biosorbent for the recovery of rare earth elements 招待 査読 国際誌

    Yukio Hosomomi, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   113   102 - 106   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2016.06.005

  • Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications 招待 査読 国際誌

    Sivapragasam, Magaret, Moniruzzaman, Muhammad, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   11 ( 8 )   1000 - 1013   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201500603

  • Cu(II)-Imprinted Chitosan Derivative Containing Carboxyl Groups for the Selective Removal of Cu(II) from Aqueous Solution 招待 査読 国際誌

    Water Yoshida, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   49 ( 7 )   630 - 634   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.15we293

  • Separation of cobalt(II) from manganese(II) using a polymer inclusion membrane with N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]glycine (D2EHAG) as the extractant/carrier 招待 査読 国際誌

    Yuzo Baba, Masahiro Goto

    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY   91 ( 5 )   1320 - 1326   2016年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jctb.4725

  • Mutual Separation of Indium, Gallium, and Zinc with the Amic Acid-type Extractant D2EHAG Containing Glycine and Amide Moieties 査読 国際誌

    Yuzo Baba, Masahiro Goto

    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN   23   9 - 18   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Ionic liquid pretreatment as emerging approaches for enhanced enzymatic hydrolysis of lignocellulosic biomass 招待 査読 国際誌

    Elgharbawy, Amal A., Moniruzzaman, Muhammad, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   109   252 - 267   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2016.01.021

  • Transcutaneous Peptide Immunotherapy of Japanese Cedar Pollinosis Using Solid-in-Oil Nanodispersion Technology. 招待 査読 国際誌

    Momoko Kitaoka, Masahiro Goto

    AAPS PharmSciTech   2015年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1208/s12249-015-0333-x

  • Great potency of seaweed waste biomass from the carrageenan industry for bioethanol production by peracetic acid-ionic liquid pretreatment 招待 査読 国際誌

    Uju, Masahiro Goto, Noriho Kamiya

    BIOMASS & BIOENERGY   81   63 - 69   2015年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biombioe.2015.05.023

  • Transcutaneous immunization against cancer using solid-in-oil nanodispersions 査読 国際誌

    Masahiro Goto

    MEDCHEMCOMM   6 ( 7 )   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c5md00168d

  • Transdermal Immunization using Solid-in-oil Nanodispersion with CpG Oligodeoxynucleotide Adjuvants 査読 国際誌

    Momoko Kitaoka, Masahiro Goto

    PHARMACEUTICAL RESEARCH   32 ( 4 )   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11095-014-1554-5

  • Transdermal Immunization using Solid-in-oil Nanodispersion with CpG Oligodeoxynucleotide Adjuvants 招待 査読 国際誌

    Momoko Kitaoka, Masahiro Goto

    PHARMACEUTICAL RESEARCH   32 ( 4 )   1486 - 1492   2015年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11095-014-1554-5

  • Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions 査読 国際誌

    MEDCHEMCOMM   6 ( 12 )   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c5md00378d

  • Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator 査読 国際誌

    Tatsuo Maruyama, Masahiro Goto

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 2 )   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/ja510156v

  • Separation of Gold(III) in Acidic Chloride Solution Using Porous Polymeric Ionic Liquid Gel 査読 国際誌

    Jian Yan, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   48 ( 3 )   2015年4月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we162

  • Supported Liquid Membrane Extraction of Reactive Dye Using Fabricated Polypropylene Membrane 査読 国際誌

    Norlisa Othman, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 10 )   2014年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.14we240

  • Application of cellulose acetate to the selective adsorption and recovery of Au(III) 査読 国際誌

    Jian Yan, Masahiro Goto

    CARBOHYDRATE POLYMERS   111   2014年10月

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    記述言語:英語  

    DOI: 10.1016/j.carbpol.2014.05.003

  • A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells 査読 国際誌

    Rie Wakabayashi, Masahiro Goto

    MEDCHEMCOMM   5 ( 10 )   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c4md00179f

  • Separation of Platinum and Palladium from Hydrochloric Acid Solutions with 1-Octyl-3-methylimidazolium Hexafluorophosphate as an Extractant 査読 国際誌

    Tkahiko Kakoi, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.14we052

  • Synergistic Extraction of Rare-Earth Metals and Separation of Scandium Using 2-Thenoyltriuoroacetone and Tri-n-octylphosphine Oxide in an Ionic Liquid System 査読 国際誌

    Zhigang Zhao, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   2014年8月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we360

  • Selective extraction of scandium from yttrium and lanthanides with amic acid-type extractant containing alkylamide and glycine moieties 査読 国際誌

    Yuzo Baba, Masahiro Goto

    RSC ADVANCES   4 ( 92 )   2014年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c4ra08897b

  • Selective adsorption and recovery of precious metal ions using protein-rich biomass as efficient adsorbents 査読 国際誌

    Tatsuo Maruyama, Masahiro Goto

    PROCESS BIOCHEMISTRY   49 ( 5 )   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.procbio.2014.02.016

  • Separation of precious metals by using undiluted ionic liquids 査読 国際誌

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   21 ( 1 )   89 - 94   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.21.89

  • One step effective separation of platinum and palladium in an acidic chloride solution by using undiluted ionic liquids 査読 国際誌

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   21 ( 2 )   129 - 135   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.21.129

  • The self-assembly and secondary structure of peptide amphiphiles determine the membrane permeation activity 査読 国際誌

    Rie Wakabayashi, Masahiro Goto

    RSC ADVANCES   4 ( 58 )   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c4ra02901a

  • Highly Efficient Extraction Separation of Lanthanides Using a Diglycolamic Acid Extractant

    Kojiro Shimojo, Fukiko Kubota, Masahiro Goto

    ANALYTICAL SCIENCES   30 ( 2 )   2014年2月

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    記述言語:英語  

  • Highly Efficient Extraction Separation of Lanthanides Using a Diglycolamic Acid Extractant 査読 国際誌

    Kojiro Shimojo, Masahiro Goto

    ANALYTICAL SCIENCES   30 ( 2 )   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Sucrose laurate-enhanced transcutaneous immunization with a solid-in-oil nanodispersion 査読 国際誌

    MEDCHEMCOMM   5 ( 1 )   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c3md00164d

  • Development of Novel Extractants with Amino Acid Structure for Efficient Separation of Nickel and Cobalt from Manganese Ions 査読 国際誌

    Yuzo Baba, Fukiko Kubota, Masahiro Goto

    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH   53 ( 2 )   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/ie403524a

  • Needle-free immunization using a solid-in-oil nanodispersion enhanced by a skin-permeable oligoarginine peptide 査読 国際誌

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   458 ( 2 )   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2013.10.006

  • Ionic Liquid-in-Oil Microemulsions as Potential Carrier for the Transdermal Delivery of Methotrexate 査読 国際誌

    Hiromu Yoshiura, Noriho Kamiya, Masahiro Goto

    J. Chem. Eng. Japan   46 ( 11 )   794 - 796   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Biosorption of Rare Earth Elements by Escherichia coli 査読 国際誌

    Yukiho Hosomomi, Fukiko Kubota, Masahiro Goto

    J. Chem. Eng. Japan   46 ( 7 )   450 - 454   2013年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Selective extraction and recovery of rare earth metals from phosphor powders in waste fluorescent lamps using an ionic liquid system

    Fan Yang, Fukiko Kubota, Masahiro Goto

    JOURNAL OF HAZARDOUS MATERIALS   254   2013年6月

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    記述言語:英語  

    DOI: 10.1016/j.jhazmat.2013.03.026

  • 薬物漏洩を制御した多層エマルションの調製と経皮吸収促進効果 査読

    安部 祐子, 後藤 雅宏

    日本膜学会   38 ( 2 )   92 - 96   2013年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • A Comparative Study of Ionic Liquids and a Conventional Organic Solvent on the Extraction of Rare-earth Ions with TOPO 査読 国際誌

    Fan Yang, Fukiko Kubota, Masahiro Goto

    Solvent Extraction Research and Development, Japan   20 ( 1 )   225 - 232   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction of Rare-Earth Ions with an 8-Hydroxyquinoline Derivative in an Ionic Liquid 査読

    Fan Yang, Fukiko Kubota, Masahiro Goto

    Solvent Extraction Research and Development, Japan   20 ( 1 )   123 - 129   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Low melting point pyridinium ionic liquid pretreatment for enhancing enzymatic saccharification of cellulosic biomass 査読 国際誌

    Uju, Masahiro Goto, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   135   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biortech.2012.06.096

  • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides 査読 国際誌

    Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    MEDCHEMCOMM   3 ( 12 )   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2md20059g

  • Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier 査読 国際誌

    Fang Yang, Noriho Kamiya, Masahiro Goto

    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS   82 ( 1 )   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejpb.2012.05.016

  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells 査読 国際誌

    Masahiro Goto, Yoshiro Tahara, Noriho Kamiya

    J. Controlled Release   16   713 - 721   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice 査読 国際誌

    K. Nose, Masahiro Goto, Yoshiki Katayama

    Nanoscale   4   3776 - 3780   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on His-tag chemistry 査読 国際誌

    Masahiro Goto, Josui Shimada, Noriho Kamiya

    Anal. Biochem.   421   541 - 546   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction and Separation of Rare Earth Metal Ions with DODGAA in Ionic liquids 査読 国際誌

    Fang Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solv. Extr. Res. Dev. Jpn,   19 ( 1 )   69 - 76   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Programmable protein protein conjugation via DNA-based self-assembly 査読 国際誌

    Masahiro Goto, Josui Shimada, Noriho Kamiya

    Chem. Commun   48   6226 - 6228   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery 査読 国際誌

    Eiichi Toorisaka, Masahiro Goto

    Acta Biomaterialia   8   653 - 658   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium 査読 国際誌

    J. Shimada, T. Maruyama, M. Kitaoka, N. Kamiya, M. Goto

    Anal. Biochem.   414   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Application of ionic liquids to extraction separation of rare earth metals with an effective diglycol amic acid extractant 査読 国際誌

    F.Kubota, Y. Shimobori, Y. Baba, Y. Koyanagi, K. Shimojo, N. Kamiya, M. Goto

    J. Chem. Eng. Japan   51   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Selective Recovery of Dysprosium and Neodymium Ions by a Supported Liquid Membrane Based on Ionic Liquids 査読 国際誌

    Y. Baba, F. Kubota, N. Kamiya, M. Goto

    Solvent Extraction Research and Development, Japan   18   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state 査読 国際誌

    M. Sakono, K. Motomura, T. Maruyama, N. Kamiya, M. Goto

    Biochem. Biophys. Res. Commu   ( 26 )   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A solid-in-oil dispersion of gold nanorods can enhance trandermal protein delivery and skin vaccination 査読 国際誌

    D. Pissuwan, K. Nose, R. Kurihara, K. Kaneko, Y. Tahara, N. Kamiya, M. Goto, Y. Katayama, T. Niidome

    Small   7   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Preparation and enzymatic behavior of surfactant-enveloped enzymes for glycosynthesis in nonaqueous aprotic media 査読 国際誌

    S. Egusa, T. Kitaoka, K. Igarashi, M. Samejima, M. Goto, H. Wariishi

    Journal of Molecular Catalysis B: Enzymatic   67   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Transcutaneous immunization by a solid-in-oil nanodispersion 査読 国際誌

    Y. Tahara, K. Namatsu, N. Kamiya, M. Hagimori, S. Kamiya, M. Arakawa, M. Goto

    Chem. Comm.   33   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation 査読 国際誌

    M. Moniruzzaman, M. Tamura, Y. Tahara, N. Kamiya, M. Goto

    Int. J. Pharm.   400   2010年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Enzymatic single-step preparation of multifunctional proteins 査読 国際誌

    H. Abe, M. Goto, N. Kamiya

    Chem. Commun.   33   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Fluorogenic Ribonuclease Protection (FRIP) Analysis of Single Nucleotide Polymorphisms (SNPs) in Japanese Rice (Oryza sativa L.) DNA for Cultivar Discrimination 査読 国際誌

    M. Kitaoka, T. Wada, T. Nishio, M. Got

    Biosci. Biotech. Biochem.   45   2010年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • バイオマス性素材を利用した貴金属イオンの選択的分離 査読

    島田雪子、二井手哲平、久保田富生子、神谷典穂、後藤雅宏

    化学工学論文集   36 ( 4 )   2010年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • One-Step Lactosylation of Hydrophobic Alcohols by Nonaqueous Biocatalysis 査読 国際誌

    Y. Okutani, S. Egusa, Y. Ogawa, T. Kitaoka, M. Goto, H. Wariishi

    Chem. Cat. Chem.   2   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Enzyme-Mediated Protein Refolding 査読 国際誌

    J. Okada, T. Maruyama, K. Motomura, K. Kuroki, K. Maenaka, M. Sakono, M. Goto

    Chem. Comm.   2009   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Enzyme-Mediated Protein Refolding

  • Uphill Transport of Rare Earth Metals through Highly Stable Supported Liquid Membrane Based on Ionic Liquid 査読 国際誌

    F. Kubota, Y. Shimobori, Y. Koyanagi, K. Shimojo, N. Kamiya, M. Goto

    Anal. Sci.   26   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Quaternary ammonium bacterial cellulose for adsorption of proteins 査読

    T. Niide, H. Shiraki, T. Oshima, Y. Baba, N. Kamiya, M. Goto

    Solvent Extr. Res. Dev., Jpn   17   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Functional glass surface displaying a glutamyl donor substrate for transglutaminase-mediated protein immobilization 査読 国際誌

    K. Sung, N. Kamiya, N. Kawata, S. Kamiya and M. Goto

    Biotechnol. J.   ( 5 )   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Proteinase-mediated drastic morphological change of peptide-amphiphile to induce supramolecular hydrogelation 査読 国際誌

    D. Koda, T. Maruyama, N. Minakuchi, K. Nakashima, and M. Goto

    Chem. Commun.   46   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Proteinase-mediated drastic morphological change of peptide-amphiphile to induce supramolecular hydrogelation

  • Ionic liquid-assisted transdermal delivery of sparingly soluble drugs 査読 国際誌

    M. Moniruzzaman, Y. Tahara, M. Tamura, N. Kamiya and M. Goto

    Chem. Commun.,   46   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ionic liquid-assisted transdermal delivery of sparingly soluble drugs

  • Solid-in-Oil化技術を利用したアスコルビン酸誘導体の経皮デリバリーシステム 招待 査読

    大熊愛子、朴洪宇、田原義朗、神谷典穂、後藤雅宏

    膜   34 ( 4 )   2009年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • A Comparative Study of SPG Membrane Emulsification in the Presence and Absence of Continuous-Phase Flow 査読 国際誌

    M. Kukisaki, M. Goto

    J. Chem. Eng. Japan   42 ( 7 )   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A Comparative Study of SPG Membrane Emulsification in the Presence and Absence of Continuous-Phase Flow

  • Preparation of Lactose-Modified Cellulose Films by a Nonaqueous Enzymatic Reaction and their Biofunctional Characteristics as a Scaffold for Cell Culture 査読 国際誌

    K. Esaka, S. Yokota, S. Egusa, Y. Okutani, Y. Ogawa, T. Kitaoka, M. Goto

    Biomacromolecules   10 ( 1265-1269 )   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Preparation of Lactose-Modified Cellulose Films by a Nonaqueous Enzymatic Reaction and their Biofunctional Characteristics as a Scaffold for Cell Culture

  • Simultaneous visual detection of single-nucleotide variations in tuna DNA using DNA/RNA chimeric probes and ribonuclease A 査読 国際誌

    M. Kitaoka, H. Ichinose, M. Goto

    Analytical Biochem.,   389   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Simultaneous visual detection of single-nucleotide variations in tuna DNA using DNA/RNA chimeric probes and ribonuclease A

  • Extraction Behavior of Indium with TOPO into Ionic Liquids 査読 国際誌

    F. Kubota, Y. Shimobori, Y. Koyanagi, K. Nakashima, K. Shimojo, N. Kamiya, M. Goto

    Solvent Extraction Research Development, Japan   16   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Extraction Behavior of Indium with TOPO into Ionic Liquids

  • Development of a novel immobilization method for enzymes from hyperthermophiles 査読 国際誌

    K. Minamihata, M. Tokunaga, N. Kamiya, S. Kiyoyama, H. Sakuraba, T. Ohshima, M. Goto

    Biotechnology Letters   21 ( 125 )   2009年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Development of a novel immobilization method for enzymes from hyperthermophiles

  • Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase 査読 国際誌

    T. Mouri, T. Shimizu, N. Kamiya, H. Ichinose, M. Goto

    Biotechnol. Prog.,   25   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase

  • Enzyme Encapsulation in Microparticles Composed of Polymerized Ionic Liquids for Highly Active and Reusable Biocatalysts 査読 国際誌

    K. Nakashima, N. Kamiya, D. Koda, T. Maruyama, M. Goto

    Org. Biomol. Chem.   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Preparation of Lactose-Modified Cellulose Films by a Nonaqueous Enzymatic Reaction and their Biofunctional Characteristics as a Scaffold for Cell Culture 査読 国際誌

    K. Esaka, S. Yokota, S. Egusa, Y. Okutani, Y. Ogawa, T. Kitaoka, M. Goto, H. Wariishi,

    Biomacromolecules   2009年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Simultaneous visual detection of single-nucleotide variations in tuna DNA using DNA/RNA chimeric probes and ribonuclease A 査読 国際誌

    M. Kitaoka, H. Ichinose, M. Goto

    Analytical Biochem.   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Surface modification of a solid-state cellulose matrix with lactose by a surfactant-enveloped enzyme in a nonaqueous medium 査読 国際誌

    S. Egusa, S. Yokota, K. Tanaka, K. Esaki, Y. Okutani, Y. Ogawa, T. Kitaoka, M. Goto, H. Wariishi,

    J. Mater. Chem.   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Biocatalysis in Water-in-Ionic Liquid Microemulsions: A Case Study with Horseradish  Peroxidase 査読 国際誌

    2009年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Metal Extraction from Water and Organic Solvents into Fluorous Solvents by Fluorinated β-Diketone and Its Application to the Colorimetric Analysis of Metal Ions 査読 国際誌

    2009年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Detection of SNPs in Fish DNA: Application of the Fluorogenic Ribonuclease Protection (FRIP) Assay for the Authentication of Food Contents" 査読 国際誌

    M. Kitaoka, N. Okamura, H. Ichinose, M. Goto

    J. Agric. Food Chem.   2008年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A solid-in-oil nanodispersion for transcutaneous protein delivery 査読 国際誌

    Y. Tahara, S. Honda, N. Kamiya, H. Piao, A. Hirata, E. Hayakawa, T. Fujii, M. Goto

    J. Control. Release   2008年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Microcapsulation of DNA and the adsorption of toxic substances 査読 国際誌

    S. Kiyoyama, T. Maruyama, N. Kamiya, M. Goto

    J. Microencapsul.   2008年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Conjugation of DNA with protein using His-tag chemistry and its application to the aptamer-based detection system 査読 国際誌

    J. Shimada, T. Maruyama, T. Hosogi, J. Tominaga, N. Kamiya, M. Goto

    Biotechnol. Lett.   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Demulsification of water-in-oil emulsions by permeation through Shirasu-porous-glass (SPG) membranes 査読 国際誌

    M. Kukizaki, M. Goto

    J.Membr. Sci.   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A Nobel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium 査読 国際誌

    H. Piao, N. Kamiya, A. Hirata, T. Fujii and M. Goto

    Pharmaceutical Research.   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction of Lanthanide Ions with an Organophosphorous Extractant into Ionic Liquids 査読 国際誌

    F. Kubota, Y. Koyanagi, K. Nakashima, K. Shimojo, N. Kamiya, M. Goto

    Solvent Extr. Res. Dev, -Jpn.   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Directed aggregation and fusion of lipid vesicles induced by DNA-surfactants 査読 国際誌

    T. Maruyama, H. Yamamura, M. Hiraki, Y. Kemori, H. Takata and M. Goto

    Colloids and Surfaces B: Biointerfaces   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Water-in-Ionic Liquid Microemulsions as a New Medium for Enzymatic Reactions 査読 国際誌

    M. M. Zaman, N. Kamiya, K. Nakashima and M. Goto

    Green Chem.   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone 査読 国際誌

    H. Yoshiura, Y. Tahara, M. Hashida, N. Kamiya, A. Hirata, T. Fujii and M. Goto

    Biochemical Engineering Journal   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Immobilization of Proteins into Microcapsules and Their Adsorption Properties with respect to Precious-Metal Ions 査読 国際誌

    Shiro Kiyoyama, Tatsuo Maruyama, Noriho Kamiya and Masahiro Goto

    Ind. Eng. Chem. Res.   2008年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A chemically modified glass surface that facilitates transglutaminase-mediated protein immobilization 査読 国際誌

    Y. Tanaka, S. Doi, N. Kamiya, N. Kawata, S. Kamiya, K. Nakama, M. Goto

    Biotechnol. Lett.   2008年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Enzymatic in situ Saccharification of Cellulose in Aqueous-Ionic Liquid Media 査読 国際誌

    N. Kamiya, Y. Matsushita, M. Hanaki, K. Nakashima, M Narita, M. Goto and H. Takahashi

    Biotechnol. Lett.   2008年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Spectrophotometric Assay for Protease Activity in Ionic Liquids Using Chromogenic Substrates 査読 国際誌

    K. Nakashima, T. Maruyama, N. Kamiya and M. Goto,

    Anal. Biochem.,   2008年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    "Spectrophotometric Assay for Protease Activity in Ionic Liquids Using Chromogenic Substrates".

  • CO2 separation facilitated by task-specific ionic liquids using a supported liquid membrane 査読 国際誌

    S. Hanioka, T. Maruyama, T. Sotani, M. Teramoto, H. Matsuyama, K. Nakashima, M. Hanaki, F. Kubota, M. Goto,

    J. Membr. Sci.   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    CO2 separation facilitated by task-specific ionic liquids using a supported liquid membrane

  • Formation of Reverse Micelles in a Room-Temperature Ionic Liquid 査読 国際誌

    M. M. Zaman, N. Kamiya, K. Nakashima and M. Goto

    ChemPhysChem.   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Formation of Reverse Micelles in a Room-Temperature Ionic Liquid

  • Recognition of Lysine Residues on Protein Surfaces Using Calixarenes and Its Application. Curr. 査読 国際誌

    T. Oshima, B. Yoshinari, K. Shimojo, and M. Goto

    Curr. Drug Discovery Tech.,   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • "Calixarene-Assisted Protein Refolding via Liquid-Liquid Extraction", 査読 国際誌

    K. Shimojo, T. Oshima, H. Naganawa, M. Goto

    Biomacromolecules,   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 'A Novel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium' 査読 国際誌

    Hongyu Piao, Noriho Kamiya, Akihiko Hirata, Takeru Fujii and Masahiro Goto

    Pharmaceutical Research, in press.   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A new "Green" Extractant of the Diglycol Amic Acid Type for Lanthanides 査読 国際誌

    H. Naganawa, K. Shimojo, H. Mitamura, Y. Sugo, J. Noro, and M. Goto

    Solv. Extr. Res. & Devel. Japan,   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Functional immobilization of recombinant alkaline phosphatases bearing a glutamyl donor substrate peptide of microbial transglutaminase,

    N.Kamiya, S.Doi, Y.Tanaka, H.Ichinose, M.Goto,

    J. Biosci. Bioeng.,   2007年9月

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    記述言語:英語  

  • Sequence-selective extraction of single-stranded DNA using DNA-functionalized reverse micelles. 査読 国際誌

    T. Maruyama, T. Hosogi, M. Goto

    Chem. Commun.   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 'Design of Polymer Brushes for Immobilizing Enzymes onto Hollow Fiber Micropores in Organic Media Reaction' 査読 国際誌

    Muneharu GOTO, Hideaki KAWAKITA, Kazuya UEZU, Satoshi TUNEDA, Kyoichi SAITO, and Masahiro GOTO,

    Biochem. Eng. J.,   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 'Preparation and characterization of a new asymmetric type of Shirasu porous glass (SPG) membrane used for membrane emulsification' 査読 国際誌

    Masato Kukizaki, Masahiro Goto

    JOURNAL OF MEMBRANE SCIENCE   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Perfluorocarbon-based liquid-liquid extraction for separation of transition metal ions., 査読 国際誌

    T. Maruyama, K. Nakashima, F. Kubota, M. Goto

    Anal. Sci.,   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions. 国際誌

    H. Yoshiura, M. Hashida, N. Kamiya, and M. Goto,

    Int. J. Pharm.   2007年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • An enzyme-labeled protein polymer bearing pendant haptens. 査読 国際誌

    J. Tominaga, N. Kamiya and M. Goto,

    Bioconjugate Chem.   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction Behavior and Separation of Lanthanides with a Diglycol Amic Acid Derivative and a Nitrogen-donor Ligand., 査読 国際誌

    K. Shimojo, H. Naganawa, J. Noro, F. Kubota, and M. Goto,

    Anal. Sci.,   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Preparation and evaluation of uniformly sized solid lipid microcapsules using membrane emulsification 査読 国際誌

    M. Kukizaki, M. Goto

    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Spontaneous formation behavior of uniform-sized microbubbles from Shirasu porous glass (SPG) membranes in the absence of water-phase flow. 査読 国際誌

    M. Kukizaki, M. Goto

    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides. 査読 国際誌

    J. Tominaga, Y. Kemori, Y. Tanaka, T. Maruyama, N. Kamiya and M. Goto

    Chem. Commun.   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction of Cytochrome c by a Functionalized Ionic Liquid Containing a Crown Ether 査読 国際誌

    F. Kubota, Y. Koyanagi, K. Nakashima, K. Shimojo, N. Kamiya and M. Goto,

    Solv. Extr. Res. & Devel. Japan,   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 'Exploring Enzymatic Catalysis at a Solid Surface: A Case Study with Transglutaminase-Mediated Protein Immobilization.' 査読 国際誌

    Yusuke Tanaka, Yukito Tsuruda, Motohiro Nishi, Noriho Kamiya, Masahiro Goto

    Org. Biomol. Chem.,   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. 国際誌

    H. Piao, N. Kamiya, A. Hirata, H. Yokoyama, T. Fujii, I. Shimizu, S. Ito, M. Goto,

    Pharmaceutical Development and Technology,   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Proteins and protein-rich biomass as environmental-friendly adsorbents selective for precious metal ions. 国際誌

    T. Maruyama, H. Matsushita, Y. Shimada, I. Kamata, M. Hanaki, S. Sonokawa, N. Kamiya, M. Goto

    Environ. Sci. Technol.   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides. 査読 国際誌

    J. Tominaga, Y. Kemori, Y. Tanaka, T. Maruyama, N. Kamiya and M. Goto

    Chem. Commun.   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Laccase-mediated degradation and reduction of toxicity of the postharvest fungicide imazalil. 査読 国際誌

    T. Maruyama, C. Komatsu, J. Michizoe, S. Sakai and M. Goto,

    Process Biochem.   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Synthesis of Cellulose In Vitro by Using a Cellulase/Surfactant Complex in a Nonaqueous Mediumc, Angew. 査読 国際誌

    2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • An enzyme-labeled protein polymer bearing pendant haptens. 査読 国際誌

    J. Tominaga, N. Kamiya and M. Goto

    Bioconjugate Chem   2007年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Proteins and protein-rich biomass as environmental-friendly adsorbents selective for precious metal ions. 査読 国際誌

    T. Maruyama, H. Matsushita, Y. Shimada, I. Kamata, M. Hanaki, S. Sonokawa, N. Kamiya, M. Goto,

    Environ. Sci. Technol.   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Inhibitiory effects of gold(III) ions on ribonuclease and deoxyribonuclease. 査読 国際誌

    T. Maruyama, S. Sonokawa, H. Matsushita and M. Goto

    J. Inorg. Biochem.   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Laccase-mediated degradation and reduction of toxicity of the postharvest fungicide imazalil. 査読 国際誌

    T. Maruyama, C. Komatsu, J. Michizoe, S. Sakai and M. Goto

    Process Biochem   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Inhibitiory effects of gold(III) ions on ribonuclease and deoxyribonuclease. 査読 国際誌

    T. Maruyama, S. Sonokawa, H. Matsushita and M. Goto,

    J. Inorg. Biochem.   2007年1月

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    掲載種別:研究論文(学術雑誌)  

  • Effects of Interfacial Tension and Viscosities of Oil and Water Phases on Monodispersed Droplet Formation Using a Shirasu-Porous-Glass (SPG) Membrane. 査読 国際誌

    M. Kukizaki, and M. Goto

    Membrane   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Size control of nanobubbles generated from Shirasu-porous-glass (SPG) membranes. 査読 国際誌

    M. Kukizaki, M. Goto

    J. Membr. Sci   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extractive Solubilization, Structural Change, and Functional Conversion of Cytochrome c in Ionic Liquids via Crown Ether Complexation. 査読 国際誌

    K. Shimojo, N. Kamiya, F. Tani, H. Naganawa, Y. Naruta and M. Goto

    Anal. Chem.   2006年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Separation of silver from photographic wastes by emulsion liquid membrane system. 査読 国際誌

    N. Othman, H. Mat, M. Goto

    JOURNAL OF MEMBRANE SCIENCE   2006年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol) 査読 国際誌

    K. Nakashima, J. Okada, T. Maruyama, N. Kamiya, M. Goto

    Sci. Technol. Adv. Mater   2006年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Homogeneous Enzymatic Reactions in Ionic Liquids with Poly(ethylene glycol)-Modified Subtilisin. 査読 国際誌

    K. Nakashima, T. Maruyama, N. Kamiya, M. Goto

    Org. Biomol. Chem   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Esterification of Lauric Acid Using Lipase Immobilized in the Micropores of a Hollow-Fiber Membrane. 査読 国際誌

    M Goto, H Kawakita, K Uezu, S Tsuneda, K Saito, M Goto, M Tamada, T Sugo

    J Amer Oil Chemists' Soc,   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Electrochemical Extraction of Proteins by Reverse Micelle Formation. 査読 国際誌

    M. Shinshi, Takayasu Sugihara, T. Osakai, M. Goto

    Langmuir   2006年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Increasing the catalytic performance of a whole cell biocatalyst harboring a cytochrome P450cam system by stabilization of an electron transfer component. 査読 国際誌

    T Mouri, N Kamiya, M Goto

    Biotechnol. Lett   2006年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Solvent Extraction of Lanthanides into an Ionic Liquid Containing N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine. 査読 国際誌

    K. Shimojo, H. Naganawa, F. Kubota, M. Goto

    Anal Biochem   2006年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Emulsion liquid membrane extraction of silver from photographic waste using CYANEX 302 as the mobile carrier. 査読 国際誌

    N. Othman, C-K. Hie, M. Goto, H. Mat

    Solv. Extr. Res. Dev. Jpn   2006年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Oral delivery of diclofenac sodium using a novel solid-in-oil suspension 査読 国際誌

    H. Piao, N Kamiya, J Watanabe, H Yokoyama, A Hirata, T Fujii, I Shimizu, S Ito, M Goto

    Int. J. Pharm   2006年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Laccase-mediated oxidative degradation of the herbicide dymron. 査読 国際誌

    T. Maruyama, C. Komatsu, J. Michizoe, H. Ichinose and M. Goto

    Biotechnol Prog   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Extraction of adenosine nucleotides by a long-chain quaternary ammonium salt 査読 国際誌

    F. Kubota, H. Yamada, M. Goto, S. Furusaki

    Solv. Extr. Res. Dev. Jpn   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Masking oligonucleotides improve sensitivity of mutation detection based on guanine quenching. 査読 国際誌

    T. Maruyama, T. Shinohara, T. Hosoki, H. Ichinose, N. Kamiya and M. Goto

    Anal Biochem   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Peroxidative catalytic behavior of cytochrome c solubilized in reverse micelles 査読 国際誌

    T. Ono, M. Goto

    Biochem. Eng. J.   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Crown Ether-Mediated Extraction and Functional Conversion of Cytochrome c in Ionic Liquids 査読 国際誌

    K. Shimojo, K. Nakashima, N. Kamiya, M. Goto

    Biomacromolecules   2006年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration. 査読 国際誌

    T. Mouri, J. Michizoe, H. Ichinose, N. Kamiya, and M. Goto

    Appl. Microbiol. biotechnol   2006年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Detection of single-base mutations by fluorogenic ribonuclease protection (FRAP) assay 査読 国際誌

    H Ichinose, M Kitaoka, N Okamura, T Maruyama, N Kamiya, M Goto

    Anal Chem   77 ( 21 )   7047 - 7053   2005年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/ac050782k

  • Comb-shaped poly(ethylene glycol)-modified subtilisin Carlsberg is soluble and highly active in ionic liquids 査読 国際誌

    K. Nakashima, T. Maruyama, N. Kamiya, M. Goto

    Chem. Commun   ( 34 )   4297 - 4299   2005年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/b505479f

  • Selective Extraction and Recovery of Cytochrome c by Liquid-Liquid Extraction Using a Calix[6]arene Carboxylic Acid Derivative 査読 国際誌

    T. Oshima, H. Higuchi, K. Ohto, K. Inoue, M. Goto

    Langmuir,   21 ( 16 )   7280 - 7284   2005年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la050364a

  • A supported liquid membrane encapsulating a surfactant-lipase complex for selective separation of organic acids 査読 国際誌

    E. Miyako, T. Maruyama, N. Kamiya, M. Goto

    Chem Eur J   11 ( 4 )   1163 - 1170   2005年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/chem.200400691

  • Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion 査読 国際誌

    E. Toorisaka, H. Ono, K. Arimori, N. Kamiya, M. Goto

    Int. J. Pharm   252 ( 1-2 )   271 - 274   2003年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

    DOI: 10.1016/S0378-5173(02)00674-9

  • Enantioselective transport of (S)-ibuprofen through a lipase-facilitated supported liquid membrane based on ionic liquids 査読 国際誌

    E. Miyako, T. Maruyama, N. Kamiya, and M. Goto

    Chem Commun   2003年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Enantioselective transport of (S)-ibuprofen through a lipase-facilitated supported liquid membrane based on ionic liquids

  • 環境汚染物質の分解を目的としたマイクロバイオリアクターの開発 査読

    道添純二、篠原謙治、丸山達生、草壁克己、前田英明、後藤雅宏

    化学工学論文集   2003年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • DNA hybridization in reverse micelles and its application to mutation detection 査読 国際誌

    L.C. Park, T. Maruyama, M. Goto

    Analyst   128 ( 2 )   161 - 165   2003年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DNA hybridization in reverse micelles and its application to mutation detection

    DOI: 10.1039/b208755n

  • Development of new surfactants for liquid surfactant membrane process 査読 国際誌

    Masahiro Goto, Fumiyuki Nakashio

    J. Chem. Eng. Japan   20 ( 2 )   157 - 164   1987年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Novel surfactant for liquid surfactant membrane processes

    DOI: 10.1252/jcej.20.157

  • Improved separation of rare earth elements using hydrophobic deep eutectic solvents: liquid-liquid extraction to selective dissolution

    Hanada, T; Schaeffer, N; Katoh, M; Coutinho, JAP; Goto, M

    GREEN CHEMISTRY   26 ( 18 )   9671 - 9675   2024年9月   ISSN:1463-9262 eISSN:1463-9270

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    出版者・発行元:Green Chemistry  

    Deep eutectic solvents (DESs) composed of a beta-diketone and phosphine oxides featuring different alkyl chain lengths were prepared and then employed as liquid-liquid extraction and dissolution media for the separation of iron, cobalt, neodymium, and dysprosium. In the dissolution the more sterically hindered DESs exhibited enhanced selectivity to neodymium, which was poorly separated using liquid-liquid extraction. The dissolution selectivity in less sterically hindered DESs could be controlled by the addition of organic acids with different alkyl chain lengths.

    DOI: 10.1039/d4gc01089b

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  • Screening of ionic liquids for the solubility enhancement of quinine using COSMO-RS

    Ahmed Shahani S., Warsi Khan H., Mohd Shaiff A., Goto M., Moniruzzaman M.

    Journal of Molecular Liquids   409   2024年9月   ISSN:01677322

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    出版者・発行元:Journal of Molecular Liquids  

    Quinine has traditionally been used in medicine to treat parasitic disease malaria due to its antimalarial activities. It is sparingly soluble in water and highly soluble in organic solvents. However, these solvents are not environmentally friendly, so greener solvents need to be explored and designed. Ionic liquids (ILs) were successfully observed to be greener and capable of dissolving biologically active compounds. However, finding a potential IL from millions of possible IL combinations is challenging. This work utilizes the conductor-like screening model for real solvents (COSMO-RS) to address this issue. This study aims to determine the dissolution behavior of quinine in ILs employing the COSMO-RS. A total of 540 IL combinations of 9 cations and 60 anions were investigated. The efficacy of each IL was evaluated by predicting the activity coefficients at infinite dilution, solvation-free energy, selectivity, capacity, and performance index (P.I.). This study reveals that ILs with shorter alkyl chains, polar and non-aromatic characteristics, and smaller anions are advantageous for the solubility enhancement of quinine. The most effective ILs, choline acetate, choline glycinate, and choline threoninate, displayed the highest selectivity, capacity, P.I., and lowest activity coefficient and solvation-free energies. The findings of the current study unlock key insights into the solubility behaviour of quinine in an aqueous solution employing ILs.

    DOI: 10.1016/j.molliq.2024.125388

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  • Prospecting <i>Ulva lactuca</i> seaweed in Java Island, Indonesia, as a candidate resource for industrial applications

    Pari, RF; Uju; Wijayanta, AT; Ramadhan, W; Hardiningtyas, SD; Kurnia, KA; Firmansyah, ML; Hana, A; Abrar, MN; Wakabayashi, R; Kamiya, N; Goto, M

    FISHERIES SCIENCE   90 ( 5 )   795 - 808   2024年9月   ISSN:0919-9268 eISSN:1444-2906

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    出版者・発行元:Fisheries Science  

    Ulva is an unutilized green seaweed that grows in the intertidal zone around the coast of Java Island, Indonesia. In this study, U. lactuca samples collected from three regions in south of Java Island (Cihara, Surade, and Tepus) were studied in terms of their chemical composition, physical properties and its bioactivity, to determine the best regions for establishing seaweed industries. The chemical characteristics differed significantly among different regions, where the seaweed from Tepus, Surade and Cihara had the highest content of protein (22.93%), carbohydrate (61.58%), and mineral (28.72%), respectively. The amino acids were dominated with L-aspartic acid and L-glutamic acid. All U. lactuca samples contained abundant pigments, such as chlorophylls and carotenoids, especially samples from Tepus. The highest content of crude ulvan was found in Surade seaweed (26.9%). Chemical and physical analyses showed the presence of S = O and C–O–S functional groups in ulvan, a sulfated polysaccharide unique to Ulva sp., with thermal degradation up to 220 °C. Crude ulvan from Surade and Tepus seaweed exhibited bioactivity to support proliferation of fibroblast cells at 100 and 1000 ppm, respectively. Based on the properties of U. lactuca, Tepus and Surade were identified as potential sites to establish aquaculture and/or processing industries.

    DOI: 10.1007/s12562-024-01799-6

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  • Ionic liquid-based dispersive liquid-liquid microextraction of succinic acid from aqueous streams: COSMO-RS screening and experimental verification

    Khan, HW; Zailan, AA; Reddy, AVB; Goto, M; Moniruzzaman, M

    ENVIRONMENTAL TECHNOLOGY   45 ( 19 )   3828 - 3839   2024年8月   ISSN:0959-3330 eISSN:1479-487X

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    記述言語:英語   出版者・発行元:Environmental Technology (United Kingdom)  

    In the present investigation, a total of 108 combinations of ionic liquids (ILs) were screened using the conductor-like screening model for real solvents (COSMO-RS) with the aid of six cations and eighteen anions for the extraction of succinic acid (SA) from aqueous streams through dispersive liquid–liquid microextraction (DLLME). Using the screened ILs, an ionic liquid-based DLLME (IL-DLLME) was developed to extract SA and the role of different reaction parameters in the effectiveness of IL-DLLME approach was investigated. COSMO-RS results suggested that, quaternary ammonium and choline cations form effective IL combinations with [OH¯], [F¯], and [SO42¯] anions due to hydrogen bonding. In view of these results, one of the screened ILs, tetramethylammonium hydroxide [TMAm][OH] was chosen as the extractant in IL-DLLME process and acetonitrile was adopted as the dispersive solvent. The highest SA removal efficiency of 97.8% was achieved using 25 μL of IL [TMAm][OH] as a carrier and 500 μL of acetonitrile as dispersive solvent. The highest amount of SA was extracted with a stir time of 20 min at 300 rpm, followed by centrifugation for 5 min at 4500 rpm. Overall, the findings showed that IL-DLLME is efficient in extracting succinic acid from aqueous environments while adhering to the first-order kinetics.

    DOI: 10.1080/09593330.2023.2234669

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  • Sustainable Synthesis of Cellulose Nanofibers from Industrial Agar Seaweed Waste Biomass Using Hydrated Deep Eutectic Solvents

    Hardiningtyas, SD; Putra, BU; Anggara, KB; Yuniasani, I; Ramadhan, W; Pari, RF; Uju; Hastuti, N; Indrawan, DA; Wakabayashi, R; Goto, M; Kamiya, N

    WASTE AND BIOMASS VALORIZATION   15 ( 8 )   4899 - 4913   2024年8月   ISSN:1877-2641 eISSN:1877-265X

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    出版者・発行元:Waste and Biomass Valorization  

    Purpose: This work evaluated the profiles of Industrial agar seaweed waste biomass (ISWB) and pretreated ISWB by using deep eutectic solvent (DESs) and NaOH. The profiles of nanocellulose obtained from pretreated ISWB (with various types of hydrogen bond donors of choline chloride (ChCl)-based hydrated DES) were also evaluated. Methods: ISWB underwent pre-treatment with either 100% wt. DES (1:1 molar ratio of ethylene glycol: citric acid) or 10% wt. NaOH at 80 °C to 90 °C. Subsequent treatment involved 10% wt. DES or ChCl-based hydrated DES with various HBDs (oxalic acid, citric acid, and urea) in a 1:2 molar ratio to produce nanocellulose. Results: Cellulose nanofibers isolated by the CE-DES approach exhibited a substantially higher yield compared with those obtained via the CE-NaOH method. CE-DES method induced swelling of ISWB and facilitate production of cellulose nanofibers. SEM images of samples indicates the presence of fibrous nanostructures across the majority of the specimens. Fourier-transform infrared (FTIR) spectroscopy demonstrated uniformity among all samples; they exhibited a consistent fingerprint pattern. X-ray diffraction (XRD) spectra indicated the presence of cellulose Type I in cellulose nanofibers produced by CE–DES, but not definitively in nanocellulose produced by the CE–NaOH method. Conclusion: Cellulose nanofibers can be isolated from ISWB by using various DES and exhibits substantial characteristics of cellulose nanofibers from different ISWB pretreatment protocols. Graphical Abstract: (Figure presented.)

    DOI: 10.1007/s12649-024-02499-z

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  • Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

    Islam, R; Nabila, FH; Wakabayashi, R; Kawaguchi, Y; Kamiya, N; Moniruzzaman, M; Goto, M

    MOLECULES   29 ( 13 )   2024年7月   eISSN:1420-3049

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    記述言語:英語   出版者・発行元:Molecules  

    Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.

    DOI: 10.3390/molecules29132995

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  • Design and validation of functionalized redox-responsive hydrogel beads for high-throughput screening of antibody-secreting mammalian cells

    Wulandari, DA; Tsuru, K; Minamihata, K; Wakabayashi, R; Egami, G; Kawabe, Y; Kamihira, M; Goto, M; Kamiya, N

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   138 ( 1 )   89 - 95   2024年7月   ISSN:1389-1723 eISSN:1347-4421

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Bioscience and Bioengineering  

    Antibody drugs play a vital role in diagnostics and therapy. However, producing antibodies from mammalian cells is challenging owing to cellular heterogeneity, which can be addressed by applying droplet-based microfluidic platforms for high-throughput screening (HTS). Here, we designed an integrated system based on disulfide-bonded redox-responsive hydrogel beads (redox-HBs), which were prepared through enzymatic hydrogelation, to compartmentalize, screen, select, retrieve, and recover selected Chinese hamster ovary (CHO) cells secreting high levels of antibodies. Moreover, redox-HBs were functionalized with protein G as an antibody-binding module to capture antibodies secreted from encapsulated cells. As proof-of-concept, cells co-producing immunoglobulin G (IgG) as the antibody and green fluorescent protein (GFP) as the reporter molecule, denoted as CHO(IgG/GFP), were encapsulated into functionalized redox-HBs. Additionally, antibody-secreting cells were labeled with protein L-conjugated horseradish peroxidase using a tyramide amplification system, enabling fluorescence staining of the antibody captured inside the beads. Redox-HBs were then applied to fluorescence-activated droplet sorting, and selected redox-HBs were degraded by reducing the disulfide bonds to recover the target cells. The results indicated the potential of the developed HTS platform for selecting a single cell viable for biopharmaceutical production.

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  • Design and validation of functionalized redox-responsive hydrogel beads for high-throughput screening of antibody-secreting mammalian cells(タイトル和訳中)

    Wulandari Diah Anggraini, Tsuru Kyosuke, Minamihata Kosuke, Wakabayashi Rie, Egami Go, Kawabe Yoshinori, Kamihira Masamichi, Goto Masahiro, Kamiya Noriho

    Journal of Bioscience and Bioengineering   138 ( 1 )   89 - 95   2024年7月   ISSN:1389-1723

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    記述言語:英語   出版者・発行元:(公社)日本生物工学会  

  • Platinum Group Metal Recycling from Spent Automotive Catalysts Using Reusable Hydrophobic Deep Eutectic Solvent

    Mayu Kamisono, Takafumi Hanada, Masahiro Goto

    ACS Sustainable Resource Management   2024年5月

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    掲載種別:研究論文(学術雑誌)  

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  • Facilitating Ulvan Extraction from Ulva lactuca via Deep Eutectic Solvent and Peracetic Acid Treatment

    Ramadhan W., Alamsyah A.D., Uju , Hardiningtyas S.D., Pari R.F., Wakabayashi R., Kamiya N., Goto M.

    ASEAN Journal of Chemical Engineering   24 ( 1 )   90 - 101   2024年4月   ISSN:16554418

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    出版者・発行元:ASEAN Journal of Chemical Engineering  

    Ulva lactuca is a green seaweed commonly called sea lettuce and contains sulphated polysaccharides that have biological activity. Despite its lack of ecological sustainability, strong acids (HCl) and strong bases (NaOH) are widely used as solvents in the conventional extraction process for ulvan. Deep eutectic solvent (DES) is an alternative to ulvan extraction solvent, which is more environmentally friendly and has low toxicity. This study aims to assess the efficacy of peracetic acid (PAA) pretreatment and post-treatment in enhancing the quality of extracted ulvan using a DES-based solvent in the extraction process. Ulvan extraction using DES with a temperature of 85-95°C for 1 hour and adding 2% PAA pretreatment, 0.1%, 0.5%, and 2% PAA post-treatment were conducted. PAA pre-and post-treatment was carried out with a 1:10 (w/v) ratio at room temperature for 30 minutes. The analysis included moisture content, yield, functional groups, sulphate content, and color. The test results revealed that ulvan treated with 2% PAA pretreatment had the highest moisture content and sulphate content, at 18.71% and 33.39%, respectively, while ulvan treated with 0.1% PAA post-treatment had the highest yield, at 41.96%. Adding peracetic acid concentration can increase the color quality of the ulvan. PAA pre-and post-treatment had a significant effect on all ulvan quality parameters.

    DOI: 10.22146/ajche.12272

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  • Amino Acid-Based Ionic Liquids as Biocompatible Extractants for Critical and Precious Metals

    Maghfirah, A; Hanada, T; Fajar, ATN; Goto, M

    ACS SUSTAINABLE CHEMISTRY & ENGINEERING   12 ( 17 )   6797 - 6805   2024年4月   ISSN:2168-0485

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Sustainable Chemistry and Engineering  

    The utilization of ionic liquids (ILs) in metal extraction has been massively studied due to their excellent extraction ability, vast structural tunability, and low volatility. However, several ILs can be severely toxic, depending on the structure. It is significant to extract metal ions in a greener way for sustainability, yet the development of low-toxicity ILs for metal extraction remains a challenge. We prepared a series of potentially biocompatible ILs composed of amino acid ester (AAE)-based cations, with varying alkyl chain lengths and amino acid types and a fixed linoleate anion. An in vitro cytotoxicity study on HeLa cells indicates that the EC50 value of the synthesized ILs was ca. 2 orders of magnitude higher than that of commercial ILs (Aliquat 336 and Cyphos 104), suggestive of the low toxicity of the newly synthesized ILs. The ILs extracted the transition metals in the following order: Ni2+ > Co2+ > Mn2+. The separation factors for Ni/Co and Co/Mn ranged from 0.8 to 55 and from 0.6 to 50, respectively. In addition, l-leucine butyl linoleate exhibited highly selective extraction toward Au3+ and Pd2+ over Pt4+ with separation factors for Au/Pt and Pd/Pt of 37 and 40 in 0.05 mol/L HCl, respectively. Thus, AAE-based ILs are promising biocompatible extractants for metals.

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  • Ionic liquid-mediated ethosome for transdermal delivery of insulin

    Nabila, FH; Islam, R; Shimul, IM; Moniruzzaman, M; Wakabayashi, R; Kamiya, N; Goto, M

    CHEMICAL COMMUNICATIONS   60 ( 30 )   4036 - 4039   2024年4月   ISSN:1359-7345 eISSN:1364-548X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Chemical Communications  

    Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.

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  • Design of Protease-Responsive Antifungal Liposomal Formulation Decorated with a Lipid-Modified Chitin-Binding Domain

    Saputra, H; Safaat, M; Santoso, P; Wakabayashi, R; Goto, M; Taira, T; Kamiya, N

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   25 ( 7 )   2024年4月   ISSN:1661-6596 eISSN:1422-0067

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Molecular Sciences  

    Candida albicans is a prevalent fungal pathogen that displays antibiotic resistance. The polyene antifungal amphotericin B (AmB) has been the gold standard because of its broad antifungal spectra, and its liposomal formulation, AmBisome, has been used widely and clinically in treating fungal infections. Herein, we explored enhancing the antifungal activity of AmBisome by integrating a small chitin-binding domain (LysM) of chitinase A derived from Pteris ryukyuensis. LysM conjugated with a lipid (LysM–lipid) was initially prepared through microbial transglutaminase (MTG)-mediated peptide tag-specific conjugation of LysM with a lipid–peptide substrate. The AmBisome formulation modified with LysM–lipid conjugates had a size distribution that was comparable to the native liposomes but an increased zeta potential, indicating that LysM–lipid conjugates were anchored to AmBisome. LysM–lipid-modified AmBisome exhibited long-term stability at 4 °C while retaining the capacity to bind chitin. Nevertheless, the antifungal efficacy of LysM–lipid-modified AmBisome against C. albicans was modest. We then redesigned a new LysM–lipid conjugate by introducing a peptide linker containing a thrombin digestion (TD) site at the C-terminus of LysM (LysM–TD linker–lipid), thereby facilitating the liberation of the LysM domain from AmBisome upon the addition of thrombin. This new AmBisome formulation anchored with LysM–TD linker–lipid exhibited superior performance in suppressing C. albicans growth in the presence of thrombin compared with the LysM–lipid formulation. These results provide a platform to design stimuli-responsive AmBisome formulations that respond to external environments and thus advance the treatment of pathogenic fungi infections.

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  • Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins 国際誌

    Hendra Saputra, Muhammad Safaat, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira, Noriho Kamiya

    RSC PHARMACEUTICS   2024年3月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

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  • Estimating the phase diagrams of deep eutectic solvents within an extensive chemical space

    Fajar, ATN; Hanada, T; Hartono, AD; Goto, M

    COMMUNICATIONS CHEMISTRY   7 ( 1 )   27   2024年2月   ISSN:2399-3669

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    記述言語:英語   出版者・発行元:Communications Chemistry  

    Assessing the formation of a deep eutectic solvent (DES) necessitates a solid-liquid equilibrium phase diagram. Yet, many studies focusing on DES applications do not include this diagram because of challenges in measurement, leading to misidentified eutectic points. The present study provides a practical approach for estimating the phase diagram of any binary mixture from the structural information, utilizing machine learning and quantum chemical techniques. The selected machine learning model provides reasonably high accuracy in predicting melting point (R2 = 0.84; RMSE = 40.53 K) and fusion enthalpy (R2 = 0.84; RMSE = 4.96 kJ mol−1) of pure compounds upon evaluation by test data. By pinpointing the eutectic point coordinates within an extensive chemical space, we highlighted the impact of the mole fractions and melting properties on the eutectic temperatures. Molecular dynamics simulations of selected mixtures at the eutectic points emphasized the pivotal role of hydrogen bonds in dictating mixture behavior.

    DOI: 10.1038/s42004-024-01116-3

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  • Engineering the Propeptide of Microbial Transglutaminase Zymogen: Enabling Substrate-Dependent Activation for Bioconjugation Applications

    Ariyoshi, R; Matsuzaki, T; Sato, R; Minamihata, K; Hayashi, K; Koga, T; Orita, K; Nishioka, R; Wakabayashi, R; Goto, M; Kamiya, N

    BIOCONJUGATE CHEMISTRY   35 ( 3 )   340 - 350   2024年2月   ISSN:1043-1802 eISSN:1520-4812

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Bioconjugate Chemistry  

    Microbial transglutaminase (MTG) from Streptomyces mobaraensis is a powerful biocatalytic glue for site-specific cross-linking of a range of biomolecules and synthetic molecules that have an MTG-reactive moiety. The preparation of active recombinant MTG requires post-translational proteolytic digestion of a propeptide that functions as an intramolecular chaperone to assist the correct folding of the MTG zymogen (MTGz) in the biosynthesis. Herein, we report engineered active zymogen of MTG (EzMTG) that is expressed in soluble form in the host Escherichia coli cytosol and exhibits cross-linking activity without limited proteolysis of the propeptide. We found that the saturation mutagenesis of residues K10 or Y12 in the propeptide domain generated several active MTGz mutants. In particular, the K10D/Y12G mutant exhibited catalytic activity comparable to that of mature MTG. However, the expression level was low, possibly because of decreased chaperone activity and/or the promiscuous substrate specificity of MTG, which is potentially harmful to the host cells. The K10R/Y12A mutant exhibited specific substrate-dependent reactivity toward peptidyl substrates. Quantitative analysis of the binding affinity of the mutated propeptides to the active site of MTG suggested an inverse relationship between the binding affinity and the catalytic activity of EzMTG. Our proof-of-concept study provides insights into the design of a new biocatalyst using the MTGz as a scaffold and a potential route to high-throughput screening of EzMTG mutants for bioconjugation applications.

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  • A Functional Hydrogel Bead-Based High-Throughput Screening System for Mammalian Cells with Enhanced Secretion of Therapeutic Antibodies

    Wulandari, DA; Tsuru, K; Minamihata, K; Wakabayashi, R; Goto, M; Kamiya, N

    ACS BIOMATERIALS SCIENCE & ENGINEERING   10 ( 1 )   628 - 636   2024年1月   ISSN:2373-9878

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Biomaterials Science and Engineering  

    Droplet-based high-throughput screening systems are an emerging technology that provides a quick test to screen millions of cells with distinctive characteristics. Biopharmaceuticals, specifically therapeutic proteins, are produced by culturing cells that secrete heterologous recombinant proteins with different populations and expression levels; therefore, a technology to discriminate cells that produce more target proteins is needed. Here, we present a droplet-based microfluidic strategy for encapsulating, screening, and selecting target cells with redox-responsive hydrogel beads (HBs). As a proof-of-concept study, we demonstrate the enrichment of hybridoma cells with enhanced capability of antibody secretion using horseradish peroxidase (HRP)-catalyzed hydrogelation of tetra-thiolate poly(ethylene glycol); hybridoma cells were encapsulated in disulfide-bonded HBs. Recombinant protein G or protein M with a C-terminal cysteine residue was installed in the HBs via disulfide bonding to capture antibodies secreted from the cells. HBs were fluorescently stained by adding the protein L-HRP conjugate using a tyramide signal amplification system. HBs were then separated by fluorescence-activated droplet sorting and degraded by reducing the disulfide bonds to recover the target cells. Finally, we succeeded in the selection of hybridoma cells with enhanced antibody secretion, indicating the potential of this system in the therapeutic protein production.

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  • L-Leucine Propyl Ester–Fatty Acid-Based Pseudo-Protic Ionic Liquids: Synthesis, Extraction Ability, and Ecotoxicity Prediction by Machine Learning

    MAGHFIRAH Ainul, FAJAR Adroit T.N., WAKABAYASHI Rie, GOTO Masahiro

    Solvent Extraction Research and Development, Japan   31 ( 1 )   31 - 40   2024年   ISSN:13417215 eISSN:21884765

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    記述言語:英語   出版者・発行元:Japan Association of Solvent Extraction  

    <p>We synthesized low-toxicity L-leucine propyl ester linoleate and L-leucine propyl ester oleate pseudo-protic ionic liquids (ILs) for benign extraction of Ni(II), Co(II), and Mn(II). The extraction ability order for both ILs was Ni(II) > Co(II) > Mn(II). In addition, we developed a machine learning model with an eXtreme Gradient Boosting regressor algorithm to evaluate and predict the ecotoxicity level of the ILs. An evaluation of the proposed regression model by cross-validation indicates that the model is reliable, with an R<sup>2</sup> value of 0.71. The prediction results indicate that the newly synthesized ILs are much less toxic than a commercially available IL (methyltrioctylammonium chloride) that is often used for metal extraction. </p>

    DOI: 10.15261/serdj.31.31

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  • L-Leucine Propyl Ester-Fatty Acid-Based Pseudo-Protic Ionic Liquids: Synthesis, Extraction Ability, and Ecotoxicity Prediction by Machine Learning

    Maghfirah, A; Fajar, ATN; Wakabayashi, R; Goto, M

    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN   31 ( 1 )   31 - 40   2024年   ISSN:1341-7215

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  • Green Leaching of Metallic Platinum Using an Ionic Liquid with Synergistic Organic Acid-Chlorinating Agent Additives

    Kamisono, M; Hanada, T; Goto, M

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   56 ( 1 )   2023年12月   ISSN:0021-9592 eISSN:1881-1299

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    出版者・発行元:Journal of Chemical Engineering of Japan  

    This study explored the potential for an environmentally friendly method for refining difficult-to-solubilise noble metals (notably platinum). Conventional noble-metal refining processes rely on the use of strong inorganic acids and oxidants, which cause significant environmental impact. To overcome these challenges, we propose a non-aqueous direct leaching process using an ionic liquid, an organic acid, and a chlorinating agent. Our findings indicate that trihexyl(tetradecyl)phosphonium chloride (P66614Cl) in combination with methanesulfonic acid and trichloroisocyanuric acid effectively solubilises metallic platinum. We investigated the leaching mechanism using ultraviolet–visible spectroscopy and confirmed that Pt(0) was oxidised to Pt(IV) to form PtCl62-Recovery of Pt from Pt-loaded P66614Cl was achieved by stripping with ammonium nitrate solution. . This work advances the development of sustainable refining methods for noble metals.

    DOI: 10.1080/00219592.2023.2228363

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  • 細胞カプセル化のための、酵素をクロスリンクしたアルブミンヒドロゲルに関する特性分析(Characterization of enzyme-crosslinked albumin hydrogel for cell encapsulation)

    Moriyama Kousuke, Inomoto Noe, Moriuchi Hidetoshi, Nihei Masanobu, Sato Miku, Miyagi Yoshiki, Tajiri Ayaka, Sato Takeshi, Tanaka Yasuhiko, Johno Yuuki, Goto Masahiro, Kamiya Noriho

    Journal of Bioscience and Bioengineering   136 ( 6 )   471 - 476   2023年12月   ISSN:1389-1723

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    記述言語:英語   出版者・発行元:(公社)日本生物工学会  

    ペルオキシダーゼ触媒によるクロスリンク形成を介して生理的な条件下でゲル化を受けるアルブミン派生物を合成した。アルブミンをカルボジイミドを用いてフェノール性水酸基(Alb-Ph-OH)で修飾し、置換度がゲル化に及ぼす影響を解析した。Alb-Ph-OHヒドロゲルの多様な特性、すなわち、ゲル化時間、膨張率、孔径、貯蔵弾性率、および酵素的な分解性は置換度とポリマー濃度の調整により容易に調節可能であった。Alb-Ph-OHヒドロゲル中にカプセル化された細胞の生存率は高かった。

  • Functionalization of Biomass-derived Activated Carbon and Electrochemical Reduction for the Recovery of Gold from Mobile Phone Leachate (vol 48, 16455, 2023)

    Firmansyah, ML; Amalina, I; Rizki, IN; Alfaza, AM; Jiwanti, PK; Jalil, AA; Goto, M

    ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING   48 ( 12 )   16469 - 16469   2023年12月   ISSN:2193-567X eISSN:2191-4281

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    出版者・発行元:Arabian Journal for Science and Engineering  

    The article "Functionalization of Biomass-derived Activated Carbon and Electrochemical Reduction for the Recovery of Gold from Mobile Phone Leachate", written by Mochamad Lutfi Firmansyah, Ilma Amalina, Intan Nurul Rizki, Asmaul Mashad Alfaza,Prastika Krisma Jiwanti, Aishah Abdul Jalil, Masahiro Goto, was originally published electronically on the publisher’s internet portal on 20 October 2023 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article changed on 9th October 2023 to © The Author(s) 2023 and the article is forthwith distributed under a Creative Commons Attribution 4.0 Interna?tional License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit.

    DOI: 10.1007/s13369-023-08499-w

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  • Aggregation, toxicity, and biodegradability study of an ionic liquid-based formulation for effective oil spill remediation

    Nazar M., Ul Hassan Shah M., Ahmad A., Goto M., Zaireen Nisa Yahya W., Moniruzzaman M.

    Chemosphere   344   140412   2023年12月   ISSN:00456535

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    記述言語:英語   出版者・発行元:Chemosphere  

    Chemical dispersants are extensively used for marine oil spill remediation. However, the increased toxicity and low biodegradability of these dispersants restrict their employment in the marine environment. Hence, in this work, we have developed an eco-friendly formulation composed of an ionic liquid,1-butyl-3-methylimidazolium lauroyl sarcosinate [BMIM][Lausar] and sorbitan monooleate (Span) 80. Micellar and interfacial parameters, dispersion effectiveness, as well as the toxicity and biodegradability of the developed formulation were investigated. Micellar properties confirmed a high degree of synergism among the surfactant molecules and the formation of stable micelle. The dispersion effectiveness, at dispersant-to-oil ratio (DOR) of 1:25 (v/v), against three crude oils (Arab, Ratawi, and Doba) was assessed. We achieved a dispersion effectiveness of 68.49%, 74.05%, and 83.43% for Ratawi, Doba, and Arab crude oil, respectively, using a 70:30 (w/w) ratio of Span 80 to [BMIM][Lausar]. Furthermore, the results obtained from optical microscopy and particle size analysis (PSA) indicated that the oil droplet size decreased with higher DOR. Additionally, acute toxicity experiments were conducted on zebrafish (Danio rerio) using the developed formulation, confirming its non-toxic behavior, with LC50 values of 800 mg/L after 96 h. The formulation also exhibited high biodegradability, with only 25.01% of the original quantity remaining after 28 days. Hence, these results suggest that the new formulation has the potential to be a highly effective and environmentally friendly dispersant for oil spill remediation.

    DOI: 10.1016/j.chemosphere.2023.140412

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  • Functionalization of Biomass-derived Activated Carbon and Electrochemical Reduction for the Recovery of Gold from Mobile Phone Leachate

    Firmansyah, ML; Amalina, I; Rizki, IN; Alfaza, AM; Jiwanti, PK; Jalil, AA; Goto, M

    ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING   48 ( 12 )   16455 - 16467   2023年12月   ISSN:2193-567X eISSN:2191-4281

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    出版者・発行元:Arabian Journal for Science and Engineering  

    In this age of cutting-edge technology, electronic equipment consumption, such as mobile phones, has increased tremendously. This was followed by a staggering increase in electronic waste (e-waste). However, it has been known that e-wastes contain higher amounts of precious metals than pristine sources, such as Au, which is valuable as an alternative precious metal source. Due to its various advantages, adsorption has emerged as one of the most common metal removal or recovery methods. A crucial aspect of adsorption is developing a cost-effective adsorbent for selective recovery of Au from the e-wastes. Thus, functionalized biomass-based adsorbent was developed to recover precious metals from e-waste. Functionalized activated carbon (ACIL900) has an appealing high adsorption capacity (116.2 mg g−1) performance and follows the chemisorption route, which fits with the monolayer model. The presence of IL boosts the adsorption efficiency due to its compatible interaction with the metal complexes. Remarkably, ACIL900 could quantitatively adsorb precious metals and several base metals from mobile phone leachate. The selective recovery of Au from the adsorbent was performed by sequential desorption using various solutions. Finally, Au was successfully recovered from the desorption solution using an electrochemical reduction process. ACIL900 was also found to maintain its performance for three adsorption–desorption cycles. This work reported the full recovery of Au from e-waste to its final pure product through the combination of adsorption, sequential desorption, and electrochemical reduction.

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  • Characterization of enzyme-crosslinked albumin hydrogel for cell encapsulation

    Moriyama, K; Inomoto, N; Moriuchi, H; Nihei, M; Sato, M; Miyagi, Y; Tajiri, A; Sato, T; Tanaka, Y; Johno, Y; Goto, M; Kamiya, N

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   136 ( 6 )   471 - 476   2023年10月   ISSN:1389-1723 eISSN:1347-4421

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Bioscience and Bioengineering  

    Albumin is an attractive component for the development of biomaterials applied as biomedical implants, including drug carriers and tissue engineering scaffolds, because of its high biocompatibility and low immunogenicity. Additionally, albumin-based gelators facilitate cross-linking reactions under mild conditions, which maintains the high viability of encapsulated living cells. In this study, we synthesized albumin derivatives to undergo gelation under physiological conditions via the peroxidase-catalyzed formation of cross-links. Albumin was modified with phenolic hydroxyl groups (Alb–Ph–OH) using carbodiimide chemistry, and the effect of degree of substitution on gelation was investigated. Various properties of the Alb–Ph–OH hydrogels, namely the gelation time, swelling ratio, pore size, storage modulus, and enzymatic degradability, were easily controlled by adjusting the degree of substitution and the polymer concentration. Moreover, the viability of cells encapsulated within the Alb–Ph–OH hydrogel was high. These results demonstrate the potential applicability of Alb–Ph–OH hydrogels as cell-encapsulating materials for biomedical applications, including tissue engineering.

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  • Engineered Active Zymogen of Microbial Transglutaminase

    Ryutaro Ariyoshi, Takashi Matsuzaki, Ryo Sato, Kosuke Minamihata, Kounosuke Hayashi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    bioRxiv,   2023年10月

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    DOI: 10.1101/2023.10.09.561484

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  • Cover Feature: Pharmaceutical Applications of Ionic Liquids: A Personal Account (Chem. Rec. 8/2023)

    Rahman Md Moshikur, Masahiro Goto

    The Chemical Record   2023年8月

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    DOI: 10.1002/tcr.202380802

  • イオン液体を利用したバイオ医薬品の経皮送達技術

    後藤 雅宏

    Drug Delivery System   38 ( 3 )   220 - 229   2023年7月   ISSN:09135006 eISSN:18812732

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    記述言語:日本語   出版者・発行元:日本DDS学会  

    イオン液体の製剤利用に近年注目が集まっている。なかでも、イオン液体の経皮吸収促進機能は、小分子の薬物のみならず、ペプチドやタンパク質などのバイオ医薬品までおよび、非侵襲性の経皮製剤の開発に大変有用である。特に、イオン液体の製剤利用においては、イオン液体の安全性を担保することが重要な課題となっている。そこで本稿では、コリン、アミノ酸、脂肪酸そして脂質など、安全性の高い素材によって形成されたイオン液体を紹介する。生体適合性の高いイオン液体の活用によって、DDSの徐放特性を発揮する中分子医薬あるいは経皮ワクチンの開発が可能となった。最近では、核酸医薬などの新しいモダリティにも、イオン液体の利用に大きな期待が寄せられている。

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  • Supramolecular localization in liquid-liquid phase separation and protein recruitment in confined droplets 査読 国際誌

    Obayashi, H; Wakabayashi, R; Kamiya, N; Goto, M

    CHEMICAL COMMUNICATIONS   59 ( 4 )   414 - 417   2023年1月   ISSN:1359-7345 eISSN:1364-548X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Chemical Communications  

    This study investigated the localization of artificial peptide supramolecular fibers in liquid?liquid phase separation (LLPS). Hierarchical organization led to the localization of supramolecules in LLPS droplets. Moreover, proteins were recruited into confined droplets by the physical adsorption of proteins on the supramolecules, enabling an enhanced cascade reaction.

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  • 注射に代わる次世代経皮ワクチン研究の最前線 – 膜学における境界領域研究として–

    後藤 雅宏

    膜   48 ( 1 )   25 - 30   2023年   ISSN:03851036 eISSN:18846440

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    記述言語:日本語   出版者・発行元:日本膜学会  

    DOI: 10.5360/membrane.48.25

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  • Effect of Hydrophobicity of Ionic Liquids on the Leaching Selectivity of Platinum from a Spent Automotive Catalyst

    Hanada, T; Takaoka, S; Kamisono, M; Fajar, ATN; Goto, M

    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN   30 ( 2 )   149 - 157   2023年   ISSN:1341-7215

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  • Molecular crowding elicits the acceleration of enzymatic crosslinking of macromolecular substrates 査読 国際誌

    Sato, R; Minamihata, K; Wakabayashi, R; Goto, M; Kamiya, N

    ORGANIC & BIOMOLECULAR CHEMISTRY   21 ( 2 )   306 - 314   2022年11月   ISSN:1477-0520 eISSN:1477-0539

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Organic and Biomolecular Chemistry  

    Cytoplasm contains high concentrations of biomacromolecules. Protein behavior under such crowded conditions is reportedly different from that in an aqueous buffer solution, mainly owing to the effect of volume exclusion caused by the presence of macromolecules. Using a crosslinking reaction catalyzed by microbial transglutaminase (MTG) as a model, we herein systematically determined how the substrate size affects enzymatic activity in both dilute and crowded solutions of dextran. We first observed a threefold reduction in MTG-mediated crosslinking of a pair of small peptide substrates in 15 wt% dextran solution. In contrast, when proteinaceous substrates were involved, the crosslinking rates in 15 wt% dextran solutions accelerated markedly to levels comparable with the level in the absence of dextran. Our results provide new insights into the action of enzymes with regard to macromolecular substrates under crowded conditions, of which the potential utility was demonstrated by the formation of highly crosslinked protein polymers.

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  • Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery

    Ali, MK; Moshikur, RM; Goto, M; Moniruzzaman, M

    PHARMACEUTICAL RESEARCH   39 ( 10 )   2335 - 2351   2022年10月   ISSN:0724-8741 eISSN:1573-904X

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    記述言語:英語   出版者・発行元:Pharmaceutical Research  

    Ionic liquids (ILs) have attracted growing interest as designer solvents/materials for exploring unrealized functions in many areas of research including drug formulations and delivery owing to their inherent tunable physicochemical and biological properties. The use of ILs in the pharmaceutical industry can address challenges related to the use of conventional organic solvent-based chemical permeation enhancers. Their tunability in forming ion pairs with a diverse range of ions enables the task-specific optimization of ILs at the molecular level. In particular, ILs comprising second- and third-generation cations and anions have been extensively used to design biocompatible drug delivery systems to address the challenges related to conventional topical and transdermal drug delivery, including limited permeability, high cytotoxicity, and skin irritation. This review highlights the progress in IL-related research with particular emphasis on the very recent conceptual developments in transdermal drug delivery. Technological advancement and approaches for the formation of IL-based topical and transdermal delivery systems, as well as their promising application in drug delivery, are also discussed.

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  • Liposomal Amphotericin B Formulation Displaying Lipid-Modified Chitin-Binding Domains with Enhanced Antifungal Activity

    Taniguchi, H; Ishimime, Y; Minamihata, K; Santoso, P; Komada, T; Saputra, H; Uchida, K; Goto, M; Taira, T; Kamiya, N

    MOLECULAR PHARMACEUTICS   19 ( 11 )   3906 - 3914   2022年9月   ISSN:1543-8384 eISSN:1543-8392

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Molecular Pharmaceutics  

    Fungal infections affect more than one billion people worldwide and cause more than one million deaths per year. Amphotericin B (AmB), a polyene antifungal drug, has been used as the gold standard for many years because of its broad antifungal spectrum, high activity, and low tendency of drug resistance. However, the side effects of AmB, such as nephrotoxicity and hepatotoxicity, have hampered its widespread use, leading to the development of a liposome-type AmB formulation, AmBisome. Herein, we report a simple but highly effective strategy to enhance the antifungal activity of AmBisome with a lipid-modified protein. The chitin-binding domain (LysM) of the antifungal chitinase, Pteris ryukyuensis chitinase A (PrChiA), a small 5.3 kDa protein that binds to fungal cell wall chitin, was engineered to have a glutamine-containing peptide tag at the C-terminus for the microbial transglutaminase (MTG)-catalyzed crosslinking reaction (LysM-Q). LysM-Q was site-specifically modified with a lysine-containing lipid peptide substrate of MTG with a palmitoyl moiety (Pal-K). The resulting palmitoylated LysM (LysM-Pal) exhibited negligible cytotoxicity to mammalian cells and can be easily anchored to yield LysM-presenting AmBisome (LysM-AmBisome). LysM-AmBisome exhibited a dramatic enhancement of antifungal activity toward Trichoderma viride and Cryptococcus neoformans, demonstrating the marked impact of displaying a cell-wall binder protein on the targeting ability of antifungal liposomal formulations. Our simple strategy with enzymatic protein lipidation provides a potent approach to upgrade other types of lipid-based drug formulations.

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  • Vegetable Oil–Ionic Liquid-Based Emulsion Liquid Membrane for the Removal of Lactic Acid from Aqueous Streams: Emulsion Size, Membrane Breakage, and Stability Study

    Khan, HW; Elgharbawy, AAM; Bustam, MA; Goto, M; Moniruzzaman, M

    ACS OMEGA   7 ( 36 )   32176 - 32183   2022年9月   ISSN:2470-1343

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    In this study, we present a highly stable vegetable oil ionic liquid (IL)-based emulsion liquid membrane (VOILELM) for the removal of lactic acid from water streams. The system developed as a part of this work comprises a non-ionic surfactant Span 80, sodium hydroxide as an internal stripping agent, sunflower canola oil as a green diluent, and IL-tetramethylammonium acetate [TMAm][Ac]-as a carrier. VOILELM stability was evaluated in terms of breakage, emulsion diameter, and standalone stability. The effect of various parameters, namely, concentration of the surfactant, concentration of the internal stripping agent, concentration of the carrier, phase ratio, homogenizer speed, and homogenization time, on the VOILELM stability was studied. The results revealed that VOILELM was highly stable, with 1.34% minimum breakage, 1.16 μm emulsion diameter, and 131 min standalone stability. The optimal process parameters were 0.1 wt % Span 80, 0.1 M NaOH, 0.3 wt % IL, 0.25 phase ratio, 5000 rpm homogenizer speed, and 5 min homogenization time. At these optimized conditions, 96.08% lactic acid extraction efficiency was achieved. Thus, a highly effective VOILELM was developed, with minimal breakage and emulsion diameter and maximum stability.

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  • Preparation of amphotericin B-loaded hybrid liposomes and the integration of chitin-binding proteins for enhanced antifungal activity

    Santoso, P; Komada, T; Ishimine, Y; Taniguchi, H; Minamihata, K; Goto, M; Taira, T; Kamiya, N

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   134 ( 3 )   259 - 263   2022年9月   ISSN:1389-1723 eISSN:1347-4421

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Bioscience and Bioengineering  

    Amphotericin B (AMB) is a gold standard antifungal drug because of its broad-spectrum activity toward pathogenic yeasts and molds. Because of its low solubility in water and toxicity toward humans, several lipid-based formulations that either increase the aqueous solubility or decrease the side effects have been employed in practical use. In our previous research, we found that the combination of AMB with an artificial palmitoylated chitin-binding domain from Pteris ryukyuensis chitinase (LysM-Pal) resulted in synergistic antifungal action against Trichoderma viride. Herein, we prepared hybrid liposomal formulations by combining a commercially available AMB formulation and liposomes with different surface charges to explore key factors in the antifungal activity. The characterization of AMB-loaded liposomal formulations (AMB-LFs), including particle size distribution and zeta potential, showed that anionic and neutral AMB-LFs could stably encapsulate AMB. The combination of either anionic or neutral AMB-LFs with unmodified LysM decreased the minimum inhibitory concentration of AMB. The combination of neutral AMB-LF with LysM-Pal resulted in a further decrease in the MIC, up to 15-fold compared with that of the neutral AMB-LF alone. Our results demonstrate the potential utility of lipid-based liposomal formulations of AMB combined with lipid-modified proteinaceous binders to tackle fungal infections.

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  • 抗真菌活性強化のためのアンフォテリシンB含有ハイブリッドリポソームの調製とキチン結合蛋白質の統合(Preparation of amphotericin B-loaded hybrid liposomes and the integration of chitin-binding proteins for enhanced antifungal activity)

    Santoso Pugoh, Komada Takuya, Ishimine Yugo, Taniguchi Hiromasa, Minamihata Kosuke, Goto Masahiro, Taira Toki, Kamiya Noriho

    Journal of Bioscience and Bioengineering   134 ( 3 )   259 - 263   2022年9月   ISSN:1389-1723

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    記述言語:英語   出版者・発行元:(公社)日本生物工学会  

    市販のアンフォテリシンB(AMB)製剤と表面電荷が異なるリポソームを組合せてハイブリッドリポソーム製剤を調製し、抗真菌活性の重要な要因を探索した。AMB含有リポソーム製剤(AMB-LF)の粒子サイズ分布とゼータ電位を含む特性評価では、陰イオン性と中性のAMB-LFはAMBを安定的にカプセル化できた。アニオン性または中性AMB-LFと未修飾LysMの組合せではAMBのMICが低下した。中性AMB-LFとPteris ryukyuensisキチナーゼ由来の人工パルミトイル化キチン結合ドメインの組合せではMICは更に減少し、中性AMB-LF単独と比較して最大15倍になった。以上より、脂質修飾性蛋白質結合剤と組合せたAMBの脂質基盤リポソーム製剤の真菌感染に対する有用であると考えられた。

  • Artificial Palmitoylation of Proteins Controls the Lipid Domain-Selective Anchoring on Biomembranes and the Raft-Dependent Cellular Internalization

    Uchida, K; Obayashi, H; Minamihata, K; Wakabayashi, R; Goto, M; Shimokawa, N; Takagi, M; Kamiya, N

    LANGMUIR   38 ( 31 )   9640 - 9648   2022年8月   ISSN:0743-7463 eISSN:1520-5827

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    Protein palmitoylation, a post-translational modification, is universally observed in eukaryotic cells. The localization of palmitoylated proteins to highly dynamic, sphingolipid- and cholesterol-rich microdomains (called lipid rafts) on the plasma membrane has been shown to play an important role in signal transduction in cells. However, this complex biological system is not yet completely understood. Here, we used a combined approach where an artificial lipidated protein was applied to biomimetic model membranes and plasma membranes in cells to illuminate chemical and physiological properties of the rafts. Using cell-sized giant unilamellar vesicles, we demonstrated the selective partitioning of enhanced green fluorescent protein modified with a C-terminal palmitoyl moiety (EGFP-Pal) into the liquid-ordered phase consisting of saturated phospholipids and cholesterol. Using Jurkat T cells treated with an immunostimulant (concanavalin A), we observed the vesicular transport of EGFP-Pal. Further cellular studies with the treatment of methyl β-cyclodextrin revealed the cholesterol-dependent internalization of EGFP-Pal, which can be explained by a raft-dependent, caveolae-mediated endocytic pathway. The present synthetic approach using artificial and natural membrane systems can be further extended to explore the potential utility of artificially lipidated proteins at biological and artificial interfaces.

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  • Protein-structure-dependent spectral shifts of near-infrared photoluminescence from locally functionalized single-walled carbon nanotubes based on avidin-biotin interactions 査読 国際誌

    Niidome, Y; Wakabayashi, R; Goto, M; Fujigaya, T; Shiraki, T

    NANOSCALE   36 ( 36 )   13090 - 13097   2022年8月   ISSN:2040-3364 eISSN:2040-3372

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nanoscale  

    Single-walled carbon nanotubes (SWCNTs) emit photoluminescence (PL) in the near-infrared (NIR) region (>900 nm). To enhance their PL properties, defect doping via local chemical functionalization has been developed. The locally functionalized SWCNTs (lf-SWCNTs) emit red-shifted and bright E11* PL originating from the excitons localized at the defect-doped sites. Here, we observe the E11* PL energy shifts induced by protein adsorption via the avidin?biotin interactions at the doped sites of lf-SWCNTs. We establish that the difference in the structures of the avidin derivatives notably influences the energy shifts. First, lf-SWCNT-tethering biotin groups (lf-SWCNTs-b) are synthesized based on diazonium chemistry, followed by post-modification. The responsiveness of the lf-SWCNTs-b to different microenvironments is investigated, and a correlation between the E11* PL energy shift and the induction-polarity parameters of surrounding solvents is established. The adsorption of neutravidin onto the lf-SWCNTs-b induces an increase in the induction-polarity parameters around the biotin-doped sites, resulting in the red-shift of the E11* PL peak. The E11* PL shift behaviors of the lf-SWCNTs-b change noticeably when avidin and streptavidin are introduced compared to the case with neutravidin. This is due to the different microenvironments formed at the biotin-doped sites, attributed to the difference in the structural features of the introduced avidin derivatives. Moreover, we successfully enhance the detection signals of lf-SWCNTs-b (>three fold) for streptavidin detection using a fabricated film device. Therefore, lf-SWCNTs exhibit significant promise for application in advanced protein detection/recognition devices based on NIR PL.

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  • Ionic Liquid and Tween-80 Mixture as an Effective Dispersant for Oil Spills: Toxicity, Biodegradability, and Optimization

    Nazar, M; Shah, MU; Ahmad, A; Yahya, WZN; Goto, M; Moniruzzaman, M

    ACS OMEGA   7 ( 18 )   15751 - 15759   2022年5月   ISSN:2470-1343

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    Chemical dispersants are used extensively for oil spill remediation. Most of these dispersants are composed of a mixture of surfactants and organic solvents, which raises concerns about aquatic toxicity and environmental impact. In this study, the toxicity and biodegradability of an oil spill dispersant composed of the surface-active ionic liquid 1-butyl-3-methylimidazolium lauroyl sarcosinate [Bmim]-[Lausar] and Tween-80 were investigated. In addition, important environmental factors including salinity, temperature, and wave-mixing energy were optimized to obtain maximum dispersion effectiveness. The acute toxicity against zebrafish (Danio rerio) showed that the developed dispersant was practically non-toxic with a median lethal dose of more than 100 mg L-1 after 96 h. The dispersant also demonstrated outstanding biodegradability of 66% after 28 days. A model was developed using a response surface methodology that efficiently (R2 = 0.992) related the salinity, temperature, and wave-mixing energy of seawater to dispersion effectiveness. The system was then optimized, and a high dispersion effectiveness of 89.70% was obtained with an experimental error of less than 2%. Our findings suggest that the surface-active ionic liquid and Tween-80 mixture could be a viable alternative to toxic chemical dispersants for oil spill remediation.

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  • イミダゾリウムカチオンをキャリアとして用いた乳化液膜によるロジウムの抽出におよぼす各種操作条件の影

    栫隆彦、後藤雅宏

    化学工学論文集   48 ( 3 )   81 - 85   2022年5月   ISSN:0386216X eISSN:13499203

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    記述言語:日本語   出版者・発行元:公益社団法人 化学工学会  

    <p>各種イオン液体,1-アルキル-3-メチルイミダゾリウムヘキサフルオロホスフェートおよび1-アルキル-3-メチルイミダゾリウムビス(トリフルオロメタンスルフォニル)イミドを輸送キャリアとして用いた乳化液膜による塩酸媒体からのロジウム(III)の抽出を行った.ロジウム(III)の抽出を促進するために,原料水溶液中にスズ(II)を添加し,ロジウムおよびスズの抽出挙動におよぼす各種操作条件の影響を検討した.各種金属の抽出速度は,イオン液体種,界面活性剤濃度,逆抽出剤濃度に大きく影響されることがわかった.イオン液体分子におけるアルキル鎖長並びに対アニオン部の構造の違いが抽出に影響をおよぼすことが示された.また,逆抽出剤として用いた2-アミノ-2-ヒドロキシメチル-1,3-プロパンジオールの存在量が多量のスズからのロジウムの選択的な抽出に影響をおよぼし,最適値が存在することが明らかとなった.本系における最適操作条件下において,迅速かつ定量的なロジウム抽出が達成された.</p>

    DOI: 10.1252/kakoronbunshu.48.81

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  • Effects of Metastatic Sites on Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer

    Bando, H; Nakamura, Y; Taniguchi, H; Shiozawa, M; Yasui, H; Esaki, T; Kagawa, Y; Denda, T; Satoh, T; Yamazaki, K; Sunakawa, Y; Kato, T; Goto, M; Yuki, S; Nishina, T; Oki, E; Shinozaki, E; Matsuhashi, N; Takahashi, N; Tsuji, A; Ohtsubo, K; Wakabayashi, M; Ikeno, T; Hata, M; Odegaard, JI; Yoshino, T

    JCO PRECISION ONCOLOGY   6   e2100535   2022年5月   eISSN:2473-4284

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    記述言語:英語  

    DOI: 10.1200/PO.21.00535

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  • Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B 国際誌

    Santoso, P; Minamihata, K; Ishimine, Y; Taniguchi, H; Komada, T; Sato, R; Goto, M; Takashima, T; Taira, T; Kamiya, N

    ACS INFECTIOUS DISEASES   8 ( 5 )   1051 - 1061   2022年4月   ISSN:2373-8227

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Infectious Diseases  

    Combinations of antifungal drugs can have synergistic antifungal activity, achieving high therapeutic efficacy while minimizing the side effects. Amphotericin B (AMB) has been used as a standard antifungal drug for fungal infections; however, because of its high toxicity, new strategies to minimize the required dose are desirable. Chitinases have recently received attention as alternative safe antifungal agents. Herein, we report the combination of palmitoylated chitinase domains with AMB to enhance the antifungal activity. The chitin-binding domain (LysM) from Pteris ryukyuensis chitinase was site-specifically palmitoylated by conjugation reaction catalyzed by microbial transglutaminase. The palmitoylated LysM (LysM-Pal) exhibited strong antifungal activity against Trichoderma viride, inhibiting the growth completely at a concentration of 2 μM. This antifungal effect of LysM-Pal was mainly due to the effect of anchoring of palmitic acid motif to the plasma membrane of fungi. A combination of AMB with LysM-Pal resulted in synergistic enhancement of the antifungal activity. Intriguingly, LysM-Pal exhibited higher level of antifungal activity enhancement than palmitoylated catalytic domain (CatD) and fusion of LysM and CatD. Addition of 0.5 μM LysM-Pal to AMB reduced the minimal inhibition concentration of AMB to 0.31 μM (2.5 μM without LysM-Pal). The possible mechanism of the synergistic effect of AMB and LysM-Pal is destabilization of the plasma membrane by anchoring of palmitic acid and ergosterol extraction by AMB and destabilization of the chitin layer by LysM binding. The combination of LysM-Pal with AMB can drastically reduce the dose of AMB and may be a useful strategy to treat fungal infections.

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  • Facile fabrication of a phosphonium-based ionic liquid impregnated chitosan adsorbent for the recovery of hexavalent chromium 査読 国際誌

    Firmansyah, ML; Ilmi, T; Mukti, RR; Patmawati; Goto, M

    RSC ADVANCES   12 ( 18 )   11207 - 11215   2022年4月   eISSN:2046-2069

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:RSC Advances  

    Chitosan adsorbents impregnated with a phosphonium-based ionic liquid (Chi_IL), trioctyldodecyl phosphonium chloride, were prepared for the adsorption of hexavalent chromium and compared to the performance of native chitosan. The physical and chemical properties of the adsorbents were characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Effects of various parameters, such as pH, adsorbent dosage, contact time, temperature, and multi-component systems, were systematically examined. Chi_IL showed a high adsorption capacity (282.6 mg g?1) compared to native chitosan (238.1 mg g?1). The adsorption kinetics of the metals followed a pseudo-second-order kinetic model, and the experimental data were a good fit for the Freundlich isotherm model. Following the isotherm and activation energy parameter, adsorption of Cr(VI) onto Chi_IL follows a chemisorption process, possibly through an anionic exchange with the anion of the IL. The thermodynamic parameters suggested that the adsorption of Cr(VI) is a spontaneous and exothermic reaction. In the column adsorption, Chi_IL exhibited a longer column exhaustion time than that of native chitosan owing to the enhanced adsorption capacity caused by the introduction of IL. Moreover, the column with the parameters of 6 cm bed depth, 5 mL min?1 flow rate, and 50 mg L?1 was able to achieve the best performance in Cr(VI) adsorption.

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  • Yttrium Recovery Process from Leaching Solution of Spent Ni-MH Batteries Using Coprecipitation and Solvent Extraction 査読 国際誌

    Takano M., Asano S., Goto M.

    Solvent Extraction Research and Development, Japan   29 ( 2 )   79 - 84   2022年4月   ISSN:13417215

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Solvent Extraction Research and Development, Japan  

    In this study, we investigated an efficient recovery method of yttrium from a sulfuric acid leaching solution of spent Ni-MH battery electrode materials. In this newly proposed method, yttrium, one of the heavy rare earths (HREEs), was coprecipitated with light rare earths (LREEs) in the preliminary crude separation, and the residual yttrium was precisely recovered by solvent extraction using di-(2-ehylhexyl) phosphoric acid (D2EHPA) as the extractant. Yttrium in the leaching solution of 0.7 g/L that remained at 0.2 g/L after the coprecipitation operation; however, it could be reduced to 0.001 ? 0.002 g/L by the solvent extraction process in the following step. In this technical report, we focused on the solvent extraction operation. The extractant, D2EHPA, has a high affinity for yttrium, and we confirmed the possibility of improving the recovery yield of yttrium from 43% by coprecipitation alone to 98% by introducing solvent extraction.

    DOI: 10.15261/serdj.29.79

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  • Recovery of nickel, cobalt and rare-earth elements from spent nickel-metal-hydride battery: Laboratory tests and pilot trials 査読 国際誌

    Takano, M; Asano, S; Goto, M

    HYDROMETALLURGY   209   105826   2022年3月   ISSN:0304-386X eISSN:1879-1158

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hydrometallurgy  

    The recycling of nickel, cobalt and rare earths from spent nickel?metal-hydride batteries was investigated. Nickel and cobalt were recovered as a nickel?cobalt mixed sulfide, which can be used as an intermediate raw material in existing nickel refineries. Rare earths were recovered as double sulfates, which can be recycled into industrial materials. In the recovery of rare earths, yttrium, a heavy rare earth, could be precipitated and recovered by co-precipitation with a light rare-earth double sulfate, which was considered impossible by the double-sulfate precipitation method because of high solubility of yttrium double sulfate. On the other hand, the coprecipitation behavior of yttrium was found to be unstable at the pilot scale because the stirring force was weaker than that in the laboratory experiments. In this study, the optimum conditions for leaching, double-sulfate precipitation, and sulfide precipitation reactions were determined in a laboratory test and the good performance was demonstrated in a pilot test. Based on the results, the estimated metal yields were 87% nickel, 90% cobalt, 54% yttrium, 99% lanthanum and 99% cerium. The nickel and cobalt impurities in the double sulfate that were recovered by this process were 0.04% and 0.005%, respectively, and the rare-earth impurities in the nickel?cobalt mixed sulfide were low at 0.049% yttrium, 0.007% lanthanum and 0.003% cerium. This process combined with a precipitation method showed a high separation performance.

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  • Extraction of salicylic acid from wastewater using ionic liquid-based green emulsion liquid membrane: COSMO-RS prediction and experimental verification

    Ting, HC; Khan, HW; Reddy, AVB; Goto, M; Moniruzzaman, M

    JOURNAL OF MOLECULAR LIQUIDS   347   118280 - 118280   2022年2月   ISSN:0167-7322 eISSN:1873-3166

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Liquids  

    Salicylic acid is an important component in cosmetics and skincare products and is widely found in aqueous streams as waste material. The present study reported the extraction of salicylic acid from wastewaters using a new technique termed as ‘ionic liquid-based emulsion liquid membrane’ (IL-ELM). Ionic liquids were introduced as carriers in IL-ELMs to enhance the emulsion stability. COSMO-RS simulation tool was employed to identify the effective IL among the 45 ILs composed of different cations and anions. It was found that IL [TMAm][Cl] (tetramethylammonium chloride) was found to be the most effective extracting agent for the extraction of salicylic acid that possesses the higher capacity, selectivity and lower activity coefficient towards analyte molecules. The COSMO-RS prediction results were in good agreement with the experimental data. Furthermore, this study optimized several operating conditions, including surfactant concentration, stripping agent concentration, IL concentration, emulsification time, homogenization speed and extraction time that affected the extraction efficiency. Overall, the proposed IL-ELM showed 90.04% extraction efficiency for salicylic acid under the optimized conditions of 0.005?M NaOH as stripping agent, 1.0?wt% Span-20 as emulsifier, 0.2?wt% [TMAm][Cl], 4000?rpm homogenization speed, 3:1 treat ratio and 25?min of extraction time.

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  • Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles 招待 査読 国際誌

    Wakabayashi, R; Imatani, R; Katsuya, M; Higuchi, Y; Noguchi, H; Kamiya, N; Goto, M

    CHEMICAL COMMUNICATIONS   58 ( 4 )   585 - 588   2022年1月   ISSN:1359-7345 eISSN:1364-548X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Chemical Communications  

    Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating?cooling protocol, while one pair with longer hydrophobic tails formed a co-assembly when an additional heating process was applied.

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  • Cellulose nanocrystals preparation from microcrystalline cellulose using ionic liquid-DMSO binary mixture as a processing medium

    Haron, GAS; Mahmood, H; Bin Noh, H; Goto, M; Moniruzzaman, M

    JOURNAL OF MOLECULAR LIQUIDS   346   118208 - 118208   2022年1月   ISSN:0167-7322 eISSN:1873-3166

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Molecular Liquids  

    Cellulose nanocrystals (CNCs) have attracted a great interest for various industrial applications due to their wide range of characteristics including compatibility, recyclability, and reproducibility. The efficient preparation of the quality cellulose nanocrystals (CNCs) from microcrystalline cellulose (MCC) utilizing ionic liquid (IL) 1-butyl-3-methylimidazoluim hydrogen sulfate ([Bmim][HSO4]) and dimethyl sulfoxide (DMSO) binary mixture was investigated and compared the results with those obtained from the pure IL. The produced CNCs were characterized using atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and x-ray diffractometry (XRD). It was observed that the average diameter of CNCs obtained with IL-cosolvent (C-CNCs), and pure IL (P-CNCs) were 50 nm and 0.77 ?m, respectively, whereas the length of C-CNCs and P-CNCs were found to be 757 nm and 2.11 ?m, respectively. The non-isothermal Coats-Redfern model with numerous mechanisms were used to model the thermal degradation kinetics of CNCs. The C-CNCs and P-CNCs exhibited lower activation energies of 86.45 and 19.10 KJ/mol respectively, than that of MCC 386.8 KJ/mol. The role of DMSO in the production of CNCs was discussed. The proposed IL based binary mixture could be an effective for the production of high quality CNCs for different applications.

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  • Yttrium Recovery Process from Leaching Solution of Spent Ni-MH Batteries Using Coprecipitation and Solvent Extraction

    Takano, M; Asano, S; Goto, M

    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN   29 ( 2 )   79 - 84   2022年   ISSN:1341-7215

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  • Solid-in-Oil(S/O)技術とバイオ分子の経皮吸収促進

    田原 義朗, 後藤 雅宏

    オレオサイエンス   22 ( 3 )   121 - 126   2022年   ISSN:13458949 eISSN:21873461

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    記述言語:日本語   出版者・発行元:公益社団法人 日本油化学会  

    <p>タンパク質や核酸などのバイオ分子は医薬品として利用され,臨床現場で大きな成果をあげるようになった。経皮吸収とは薬を皮膚から送達する方法であり,注射投与と比較して,安全かつ簡便な方法であることから,バイオ分子を経皮吸収させるための技術開発が注目されている。バイオ分子を油中にナノメートルサイズの粒子として分散させるSolid-in-Oil(S/O)技術は,経皮吸収促進効果をもつ油状基剤とバイオ分子を組み合わせることができることから,バイオ分子の経皮吸収において非常に有効であることが知られており,インスリンのようなタンパク質の経皮吸収効率の向上が報告されている。近年では,塗り薬型ワクチンの開発などが盛んに研究されており,抗原特異的な抗体産生や細胞性免疫の誘導が可能であることが明らかとなっている。今後の発展によって,S/O技術によるバイオ分子の経皮吸収製剤が実用化されることが期待される。</p>

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  • Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery

    Rahman Md Moshikur, Md. Korban Ali, Muhammad Moniruzzaman, Masahiro Goto

    Current Opinion in Colloid & Interface Science   56   101515 - 101515   2021年12月

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    DOI: 10.1016/j.cocis.2021.101515

  • Design of Swollen Lipidic Cubic Phase to Increase Transcutaneous Penetration of Biomacromolecules

    Shuto Kozaka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ACS Applied Materials and Interfaces   13 ( 46 )   54753 - 54761   2021年11月

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    DOI: 10.1021/acsami.1c16659

  • Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   608   2021年10月

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    DOI: 10.1016/j.ijpharm.2021.121129

  • Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion

    Md Rafiqul Islam, Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Materials and Interfaces   13 ( 36 )   42461 - 42472   2021年9月

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    DOI: 10.1021/acsami.1c11533

  • An ionic liquid extractant dissolved in an ionic liquid diluent for selective extraction of Li(I) from salt lakes

    Chunqing Cai, Takafumi Hanada, Adroit T. N. Fajar, Masahiro Goto

    DESALINATION   509   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.desal.2021.115073

  • Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug

    Shihab Uddin, Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Bio Materials   4 ( 8 )   6256 - 6267   2021年8月

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    DOI: 10.1021/acsabm.1c00563

  • Favipiravir-Based Ionic Liquids as Potent Antiviral Drugs for Oral Delivery: Synthesis, Solubility, and Pharmacokinetic Evaluation

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Molecular Pharmaceutics   18 ( 8 )   3108 - 3115   2021年8月

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    DOI: 10.1021/acs.molpharmaceut.1c00324

  • Orthogonal Enzymatic Conjugation Reactions Create Chitin Binding Domain Grafted Chitinase Polymers with Enhanced Antifungal Activity. 国際誌

    Kosuke Minamihata, Yusuke Tanaka, Pugoh Santoso, Masahiro Goto, Dan Kozome, Toki Taira, Noriho Kamiya

    Bioconjugate chemistry   32 ( 8 )   1688 - 1698   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.bioconjchem.1c00235

  • Orthogonal Enzymatic Conjugation Reactions create Chitin Binding Domain-Grafted Chitinase Polymers with Enhanced Antifungal Activity 招待 査読 国際誌

    @Kosuke Minamihata, #Yusuke Tanaka, #Pugoh Santoso,@Masahiro Goto, @Dan Kozome,@Toki Taira, @Noriho Kamiya

    Bioconjugate Chemistry   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Recovery of platinum group metals from a spent automotive catalyst using polymer inclusion membranes containing an ionic liquid carrier

    Adroit T. N. Fajar, Takafumi Hanada, Masahiro Goto

    JOURNAL OF MEMBRANE SCIENCE   629   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.memsci.2021.119296

  • Extending the Half-Life of a Protein in Vivo by Enzymatic Labeling with Amphiphilic Lipopeptides

    Mari Takahara, Shinichi Mochizuki, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Kazuo Sakurai, Noriho Kamiya

    Bioconjugate Chemistry   2021年3月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.bioconjchem.1c00027

  • Strategies for Making Multimeric and Polymeric Bifunctional Protein Conjugates and Their Applications as Bioanalytical Tools.

    Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   37 ( 3 )   425 - 437   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.20SCR07

  • Amide-functionalised phosphonium-based ionic liquids as ligands for rhodium(iii) extraction

    Wataru Yoshida, Masahiro Goto

    RSC ADVANCES   11 ( 16 )   9386 - 9394   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/d1ra00489a

  • pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures. 国際誌

    Rie Wakabayashi, Ayato Higuchi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya

    International journal of molecular sciences   22 ( 7 )   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms22073459

  • Synergistic Deep Eutectic Solvents for Lithium Extraction

    Takafumi Hanada, Masahiro Goto

    ACS SUSTAINABLE CHEMISTRY & ENGINEERING   9 ( 5 )   2152 - 2160   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acssuschemeng.0c07606

  • Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel 招待 査読 国際誌

    Wahyu Ramadhan, Genki Kagawa, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Scientific reports   10 ( 1 )   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-63362-4

  • Solid-in-oil nanodispersions as a novel delivery system to improve the oral bioavailability of bisphosphate, risedronate sodium 査読

    Yanting Hou, Hongyu Piao, Yoshiro Tahara, Shouhong Qin, Jingying Wang, Qingliang Kong, Meijuan Zou, Gang Cheng, Masahiro Goto

    European Journal of Pharmaceutical Sciences   155   105521 - 105521   2020年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejps.2020.105521

  • Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant

    Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   320   2020年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2020.114424

  • Dual-Functionalizable Streptavidin-SpyCatcher-Fused Protein-Polymer Hydrogels as Scaffolds for Cell Culture

    Kosuke Minamihata, Yusei Hamada, Genki Kagawa, Wahyu Ramadhan, Ayato Higuchi, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   3 ( 11 )   7734 - 7742   2020年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.0c00940

  • Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation. 国際誌

    Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical communications (Cambridge, England)   56 ( 89 )   13756 - 13759   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/d0cc04491a

  • Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids 招待 査読 国際誌

    Wahyu Ramadhan, Yuki Ohama, Kosuke Minamihata, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   130 ( 4 )   416 - 423   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jbiosc.2020.05.010

  • Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect 査読 国際誌

    Yoshiro Tahara, Kaho Morita, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Molecular Pharmaceutics   17 ( 10 )   3845 - 3856   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.0c00598

  • Dual-Functionalizable Streptavidin–SpyCatcher-Fused Protein–Polymer Hydrogels as Scaffolds for Cell Culture 招待 査読 国際誌

    3   7734 - 7742   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.1021/acsabm.0c00940

  • Design and Characterization of Fatty Acid-Based Amino Acid Ester as a New “Green” Hydrophobic Ionic Liquid for Drug Delivery 査読

    8 ( 36 )   13660 - 13671   2020年9月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    Ionic liquid (IL)-based drug delivery systems have attracted considerable interest owing to their intrinsic tunability and ability to transport small or large molecules through the skin. However, the development of "green"ILs remains challenging. Herein, eight potentially "green"fatty acid-based amino acid ILs (FAAAE-ILs) were synthesized, and their potency in transdermal drug delivery was investigated using ibuprofen and a peptide drug. The synthesized ILs were characterized to evaluate their physicochemical, thermal, and biological (cytotoxicity) properties. The in vitro skin permeability of the synthesized FAAAE-ILs was evaluated through pig skin. All of the FAAAE-ILs are liquid at room temperature and freely miscible with pharmaceuticals-permitted solvents/agents (e.g., isopropyl myristate (IPM), Span-20, and DMSO). In vitro cytotoxicity study showed that the cell viability of all FAAAE-ILs (10% in IPM) was at least 10 times lower than that for a conventional chemical permeation enhancer (CPE), sodium lauryl sulfate. FAAAE-ILs facilitated excellent ibuprofen solubility through multiple hydrogen bonding interactions between the drug and the ILs. An in vitro permeation study showed that the FAAAE-ILs were more effective in enhancing the permeability of drug molecules than the conventional CPE transcutol. The linoleate-based ILs showed a higher degree of permeation than the oleate-based ILs. Among the linoleate-based ILs and ibuprofen formulations (drug in 10% IL in IPM), the l-proline ethyl ester linoleate ([l-ProEt][Lin])-based formulation exhibited best results, followed by β-alanine ethyl ester linoleate, d-proline ethyl ester linoleate, and l-leucine ethyl ester linoleate after 48 h. Interestingly, the same FAAAE-IL ([l-ProEt][Lin])-containing formulation showed significant enhancement of peptide penetration across pig skin compared with CPE-containing formulations (10% in IPM). The results demonstrate that the FAAAE-IL is a promising green alternative to conventional CPEs for the transdermal delivery of small and large therapeutic molecules.

    DOI: 10.1021/acssuschemeng.0c03419

  • Liquid Liquid Extraction of Cd(II) and Zn(II) Using a Novel Tetraalkylphosphonium-Based Ionic Liquid

    Mochamad L. Firmansyah, Adroit T. N. Fajar, Wataru Yoshida, Takafumi Hanada, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   53 ( 9 )   469 - 476   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.20we030

  • Monoolein Assisted Oil-Based Transdermal Delivery of Powder Vaccine 査読

    Momoko Kitaoka, Atsushi Oka, Masahiro Goto

    Pharmaceutics   2020年8月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/pharmaceutics12090814

  • Selective Separation of Platinum Group Metals via Sequential Transport through Polymer Inclusion Membranes Containing an Ionic Liquid Carrier 査読

    Adroit T. N. Fajar, Takafumi Hanada, Mochamad L. Firmansyah, Fukiko Kubota, Masahiro Goto

    ACS Sustainable Chemistry & Engineering   8 ( 30 )   11283 - 11291   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acssuschemeng.0c03205

  • Poly(ethylene glycol)-based biofunctional hydrogels mediated by peroxidase-catalyzed cross-linking reactions 査読

    Rie Wakabayashi, Wahyu Ramadhan, Kousuke Moriyama, Masahiro Goto, Noriho Kamiya

    Polymer Journal   in press ( 8 )   899 - 911   2020年8月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41428-020-0344-7

  • Screening of ionic liquids for the extraction of biologically active compounds using emulsion liquid membrane COSMO-RS prediction and experiments 査読

    Huma Warsi Khan, Ambavaram Vijaya Bhaskar Reddy, Mohamed Mahmoud Elsayed Nasef, Mohamad Azmi Bustam, Masahiro Goto, Muhammad Moniruzzaman

    Journal of Molecular Liquids   309   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2020.113122

  • Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids. 査読

    Wahyu Ramadhan, Yuki Ohama, Kosuke Minamihata, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Journal of bioscience and bioengineering   130 ( 4 )   416 - 423   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jbiosc.2020.05.010

  • PolyTag: A peptide tag that affords scaffold-less covalent protein assembly catalyzed by microbial transglutaminase. 査読 国際誌

    R Sato, K Minamihata, R Wakabayashi, M Goto, N Kamiya

    Analytical biochemistry   600   113700 - 113700   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ab.2020.113700

  • Effective Transcutaneous Delivery of Hyaluronic Acid Using an Easy-to-Prepare Reverse Micelle Formulation 査読

    Shuto Kozaka, Ayaka Kashima, RIe Wakabayashi, Takahiro Nakata, Taro Ueda, Masahiro Goto

    Cosmetics   7 ( 3 )   52 - 52   2020年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cosmetics7030052

  • Ionic liquid polymer materials with tunable nanopores controlled by surfactant aggregates: A novel approach for CO2 capture 査読 国際誌

    A. V. B. Reddy, M. Moniruzzaman, M. A. Bustam, M. Goto, B. B. Saha, C. Janiak

    Journal of Materials Chemistry A   15034 - 15041   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    その他リンク: https://doi.org/10.1039/C9TA13077B

  • Transport of Rhodium(III) from Chloride Media across a Polymer Inclusion Membrane Containing an Ionic Liquid Metal Ion Carrier 査読

    Takafumi Hanada, Mochamad Lutfi Firmansyah, Wataru Yoshida, Fukiko Kubota, Spas D. Kolev, Masahiro Goto

    ACS Omega   5 ( 22 )   12989 - 12995   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsomega.0c00867

  • PolyTag: a peptide tag that affords scaffold-less covalent protein assembly catalyzed by a microbial transglutaminase 査読

    R Sato, K Minamihata, R Wakabayashi, M Goto, N Kamiya

    Analytical Biochemistry   113700   2020年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

  • Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel. 査読 国際誌

    Wahyu Ramadhan, Genki Kagawa, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Scientific reports   10 ( 1 )   6710 - 6710   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-63362-4

  • Biocompatible Ionic Liquid Surfactant-Based Microemulsion as a Potential Carrier for Sparingly Soluble Drugs 査読

    Md. Korban Ali, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    ACS Sustainable Chemistry & Engineering   2020年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acssuschemeng.9b07773

  • Linear Polymerization of Protein by Sterically Controlled Enzymatic Cross-Linking with a Tyrosine-Containing Peptide Loop 査読

    Dani Permana, Kosuke Minamihata, Ryo Sato, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Omega   5 ( 10 )   5160 - 5169   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsomega.9b04163

  • A novel binary supercooled liquid formulation for transdermal drug delivery 査読

    Yuya Hirakawa, Hiroshi Ueda, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Biological and Pharmaceutical Bulletin   43 ( 3 )   393 - 398   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1248/bpb.b19-00642

  • Carboxylated-cellulose nanofibers from oil palm empty fruit bunches enhanced extractive fermentation in microbial biobutanol production 査読

    N. Hastuti, R. F. Darmayanti, S. D. Hardiningtyas, K. Kanomata, K. Sonomoto, M. Goto, T. Kitaoka

    International Conference on Forest Products: Adopting the Renewable Bioenergy and Waste Utilization to Support Circular Economy and Sustainable Environment, ICFP 2019 IOP Conference Series: Earth and Environmental Science   415 ( 1 )   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1088/1755-1315/415/1/012019

  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier. 国際誌

    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 2 )   645 - 655   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.9b01104

  • Recent advances of enzymatic reactions in ionic liquids: Part II 査読

    Amal A.M. Elgharbawy, Muhammad Moniruzzaman, Masahiro Goto

    Biochemical Engineering Journal   154   107426 - 107426   2020年2月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2019.107426

  • Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   299   2020年2月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2019.112166

  • A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies 査読 国際誌

    12 ( 3 )   205 - 205   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    An allergy to cow's milk proteins is the most common food allergy in infants and toddlers. Conventional oral immunotherapy for cow's milk allergies requires hospital admission due to the risk of severe allergic reactions, including anaphylaxis. Therefore, a simpler and safer immunotherapeutic method is desirable. We examined transcutaneous immunotherapy with a solid-in-oil (S/O) system. In the S/O system, nano-sized particles of proteins are dispersed in an oil-vehicle with the assistance of nonionic surfactants. In the present study, the S/O system enhanced the skin permeation of the allergen molecule β-lactoglobulin (BLG), as compared with a control PBS solution. The patches containing BLG in the S/O nanodispersion skewed the immune response in the allergy model mice toward T helper type 1 immunity, indicating the amelioration of allergic symptoms. This effect was more pronounced when the immunomodulator resiquimod (R-848) was included in the S/O system.

    DOI: 10.3390/pharmaceutics12030205

  • Separation and Recovery of Scandium from Sulfate Media by Solvent Extraction and Polymer Inclusion Membranes with Amic Acid Extractants

    Wataru Yoshida, Fukiko Kubota, Yuzo Baba, Spas D. Kolev, Masahiro Goto

    ACS OMEGA   4 ( 25 )   21122 - 21130   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsomega.9b02540

  • Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses. 査読

    Kong Q, Kitaoka M, Tahara Y, Wakabayashi R, Kamiya N, Goto M

    International journal of pharmaceutics   572   118777   2019年12月

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    Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses.

    DOI: 10.1016/j.ijpharm.2019.118777

  • New insight into transdermal drug delivery with supersaturated formulation based on co-amorphous system 査読

    Yuya Hirakawa, Hiroshi Ueda, Tetsuya Miyano, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   569   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2019.118582

  • Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy. 査読

    Kong Q, Higasijima K, Wakabayashi R, Tahara Y, Kitaoka M, Obayashi H, Hou Y, Kamiya N, Goto M

    Pharmaceutics   11 ( 11 )   2019年10月

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    記述言語:その他  

    Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy.

    DOI: 10.3390/pharmaceutics11110563

  • Solid-in-oil-in-water(S/O/W)型多層エマルションとDDS への応用

    田原義朗, 後藤雅宏

    オレオサイエンス   19 ( 5 )   15 - 20   2019年9月

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  • A nano-sized gel-in-oil suspension for transcutaneous protein delivery 査読

    Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

    International Journal of Pharmaceutics   567   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2019.118495

  • イオン液体という第3の液体を用いた創薬研究

    田原義朗, 後藤雅宏

    日本化学会バイオテクノロジー部会ニュースレター   23 ( 1 )   3 - 12   2019年8月

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    記述言語:その他  

  • A nano-sized gel-in-oil suspension for transcutaneous protein delivery 査読 国際誌

    Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

    567   118495 - 118495   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A nano-sized gel-in-oil suspension for transcutaneous protein delivery
    We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.

    DOI: 10.1016/j.ijpharm.2019.118495

  • Nanocellulose from oil palm biomass to enhance microbial fermentation of butanol for bioenergy applications 査読

    Novitri Hastuti, Rizki Fitria Darmayanti, Safrina Dyah Hardiningtyas, Kyohei Kanomata, Kenji Sonomoto, Masahiro Goto, Takuya Kitaoka

    BioResources   14 ( 3 )   6936 - 6957   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 油状ナノ基剤を用いたDDS 技術と非侵襲性経皮ワクチンへの応用

    田原義朗, 後藤雅宏

    化学工学   83 ( 7 )   408 - 411   2019年7月

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  • Enzymatically Prepared Dual Functionalized Hydrogels with Gelatin and Heparin to Facilitate Cellular Attachment and Proliferation 査読

    Wahyu Ramadhan, Genki Kagawa, Yusei Hamada, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   2 ( 6 )   2600 - 2609   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00275

  • Polymerization of Horseradish Peroxidase by a Laccase-Catalyzed Tyrosine Coupling Reaction. 査読 国際誌

    Dani Permana, Kosuke Minamihata, Tsuneyuki Tatsuke, Jae M Lee, Takahiro Kusakabe, Masahiro Goto, Noriho Kamiya

    Biotechnology journal   14 ( 6 )   e1800531   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201800531

  • Enzymatically Prepared Dual Functionalized Hydrogels with Gelatin and Heparin to Facilitate Cellular Attachment and Proliferation 査読

    Wahyu Ramadhan, Genki Kagawa, Yusei Hamada, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   2 ( 6 )   2600 - 2609   2019年6月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00275

  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity 査読

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   55   7737 - 7740   2019年6月

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    記述言語:その他  

    Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

  • Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery 査読

    Wakabayashi Rie, Obayashi Hiroki, Hashimoto Ryuichiro, Kamiya Noriho, Goto Masahiro

    CHEMICAL COMMUNICATIONS   55 ( 49 )   6997 - 7000   2019年6月

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    記述言語:その他  

    Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery

    DOI: 10.1039/c9cc02473e

  • Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates 査読

    Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   25 ( 30 )   7315 - 7321   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/chem.201900370

  • Synthesis and characterization of choline–fatty-acid-based ionic liquids: A new biocompatible surfactant 査読

    551 ( 1 )   72 - 80   2019年5月

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    記述言語:その他  

  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations 査読

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   565   219 - 226   2019年5月

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    記述言語:その他  

    In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations

  • Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates 査読 国際誌

    Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   25 ( 30 )   7315 - 7321   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/chem.201900370

  • Transcutaneous Codelivery of Tumor Antigen and Resiquimod in Solid-in-Oil Nanodispersions Promotes Antitumor Immunity 査読

    Rie Wakabayashi, Hidetoshi Kono, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    ACS Biomaterials Science & Engineering   5 ( 5 )   2297 - 2306   2019年4月

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    記述言語:その他  

    Transcutaneous Codelivery of Tumor Antigen and Resiquimod in Solid-in-Oil Nanodispersions Promotes Antitumor Immunity

  • Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation 査読

    Rahman Md. Moshikur, Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   278 ( 15 )   226 - 233   2019年3月

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    記述言語:その他  

    Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation

  • Selective Separation and Recovery of Pt(IV) from Pd(II) through an Imidazolium-ionic-liquid-based Supported Liquid Membrane

    Wataru Yoshida, Fukiko Kubota, Riho Kono, Masahiro Goto

    ANALYTICAL SCIENCES   35 ( 3 )   343 - 346   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.18N020

  • Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery 査読

    Muhamad Alif Razi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Langmuir   35 ( 7 )   2610 - 2618   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b02809

  • Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery 査読

    Razi Muhamad Alif, Wakabayashi Rie, Goto Masahiro, Kamiya Noriho

    LANGMUIR   35 ( 7 )   2610 - 2618   2019年2月

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    記述言語:その他  

    Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery

    DOI: 10.1021/acs.langmuir.8b02809

  • Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor 査読

    Shuto Kozaka, Rie Wakabayashi, Onofrio Annunziata, Milan Balaz, Masahiro Goto, Noriho Kamiya, Sergei V. Dzyuba

    Journal of Photochemistry and Photobiology A: Chemistry   369   115 - 118   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jphotochem.2018.10.006

  • Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique 査読

    Hardiningtyas Safrina Dyah, Wakabayashi Rie, Ishiyama Ryutaro, Owada Yuki, Goto Masahiro, Kamiya Noriho

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   138 - 143   2019年1月

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    記述言語:その他  

    Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

    DOI: 10.1252/jcej.18we060

  • Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor 査読

    Kozaka Shuto, Wakabayashi Rie, Annunziata Onofrio, Balaz Milan, Goto Masahiro, Kamiya Noriho, Dzyuba Sergei V

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY   369   115 - 118   2019年1月

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    記述言語:その他  

    Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor

    DOI: 10.1016/j.jphotochem.2018.10.006

  • Antigen Delivery Targeting Tumor-Associated Macrophages Overcomes Tumor Immune Resistance 査読

    Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Yoshiro Tahara, Keisuke Fujii, Isao Tawara, Yoshihiro Miyahara, Kana Okamori, Hideo Yagita, Seiya Imoto, Rui Yamaguchi, Mitsuhiro Komura, Satoru Miyano, Masahiro Goto, Shin-ichi Sawada, Akira Asai, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada, Hiroshi Shiku

    Journal of Clinical Investigation   129 ( 3 )   1278 - 1294   2019年1月

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    記述言語:英語  

    Antigen Delivery Targeting Tumor-Associated Macrophages Overcomes Tumor Immune Resistance

  • Ionic liquids for pretreatment of biomass

    A. Vijaya Bhaskar Reddy, Muhammad Moniruzzaman, Masahiro Goto

    Comprehensive Biotechnology   190 - 198   2019年1月

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    記述言語:英語  

    DOI: 10.1016/B978-0-444-64046-8.00121-X

  • Selective recovery of platinum group metals from spent automotive catalysts by leaching and solvent extraction 査読

    Mochamad L. Firmansyah, Fukiko Kubota, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 11 )   835 - 842   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.19we093

  • Multifunctional effect of the polymer extractant thiomethylbenzoxazoyl-α-methylstyrene on the extraction of Au(III) 査読

    26 ( 2 )   91 - 98   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In this study, we synthesized a polymer extractant and its monomer analogue, and the multifunctional effect was investigated by comparing their extraction behavior for Au(III). To increase the affinity for gold ions, we introduced a sulfur atom into the molecular structure of the extractant as a soft donor. The extraction ability of the new extractants for gold ions was influenced by the HCl concentration in the aqueous feed solution. The multifunctional effect appeared when using the polymer extractant in the liquid–liquid extraction of gold ions. Selectivity of the extractants toward Au(III) was evaluated using a model solution generated from leaching of waste cellphones. Selectivity for Au(III) was found to be enhanced by the multifunctional effect of the polymer extractant.

    DOI: 10.15261/serdj.26.91

  • Ionic Liquid Pretreatment of Lignocellulosic Biomass for Enhanced Enzymatic Delignification

    Muhammad Moniruzzaman, Masahiro Goto

    Advances in Biochemical Engineering/Biotechnology   61 - 77   2019年1月

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    記述言語:英語  

    DOI: 10.1007/10_2018_64

  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity 査読

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   55 ( 54 )   7737 - 7740   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c9cc02812a

  • Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery 査読

    Rie Wakabayashi, Hiroki Obayashi, Ryuichiro Hashimoto, Noriho Kamiya, Masahiro Goto

    Chemical Communications   55 ( 49 )   6997 - 7000   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c9cc02473e

  • An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms 査読

    Magaret Sivapragasam, Muhammad Moniruzzaman, Masahiro Goto

    Biotechnology Journal   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201900073

  • Polymerization of Horseradish Peroxidase by a Laccase-Catalyzed Tyrosine Coupling Reaction 査読

    Dani Permana, Kosuke Minamihata, Tsuneyuki Tatsuke, Jae M. Lee, Takahiro Kusakabe, Masahiro Goto, Noriho Kamiya

    Biotechnology Journal   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201800531

  • Enhanced potential of therapeutic applications of curcumin using solid-in-water nanodispersion technique 査読

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Ryutaro Ishiyama, Yuki Owada, Masahiro Goto, Noriho Kamiya

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   138 - 143   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.18we060

  • Design of Lipid-Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase 査読

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   1 ( 6 )   1823 - 1829   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.8b00271

  • S/O技術によるペプチドの経皮吸収

    田原義朗, 後藤雅宏

    13 ( 2 )   48 - 52   2018年12月

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    記述言語:その他  

  • Liquid Marbles as an Easy-to-Handle Compartment for Cell-Free Synthesis and In Situ Immobilization of Recombinant Proteins. 国際誌

    Noriho Kamiya, Yuki Ohama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto

    Biotechnology journal   13 ( 12 )   e1800085   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201800085

  • Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control 査読

    Wakabayashi Rie, Suehiro Ayumi, Goto Masahiro, Kamiya Noriho

    Chemical Communications, accepted.   2018年12月

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    記述言語:その他  

    Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control

  • Design of Lipid-Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase 査読

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   1 ( 6 )   1823 - 1829   2018年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.8b00271

  • Laccase-catalyzed bioconjugation of tyrosine-tagged functional proteins 査読

    Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   126 ( 5 )   559 - 566   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jbiosc.2018.05.013

  • Solid-in-Oil(S/O)化技術と経皮ワクチンへの応用 招待

    田原義朗, 後藤雅宏

    34 ( 14 )   199 - 202   2018年11月

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    記述言語:その他  

  • Laccase-catalyzed bioconjugation of tyrosine-tagged functional proteins. 査読

    Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Journal of bioscience and bioengineering   126 ( 5 )   559 - 566   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jbiosc.2018.05.013

  • イオン液体を用いたDDSと経皮デリバリーへの応用の現状 招待

    田原義朗, 後藤雅宏

    33 ( 4 )   303 - 310   2018年9月

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  • Design of lipid-protein conjugate with a self-assembling ability on a cell membrane by using microbial transglutaminase reaction 査読

    Takahara Mari, Wakabayashi Rie, Minamihata Kosuke, Goto Masahiro, Kamiya Noriho

    ACS Appl. Bio Mater., accepted. DOI: 10.1021/acsabm.8b00271.   2018年8月

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    Design of lipid-protein conjugate with a self-assembling ability on a cell membrane by using microbial transglutaminase reaction

  • Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids 査読

    Rahman Md. Moshikur, Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   546 ( 1-2 )   31 - 38   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2018.05.021

  • Mesoscopic Heterogeneity in Pore Size of Supramolecular Networks 査読

    Yuji Matsumoto, Atsuomi Shundo, Masashi Ohno, Nobutomo Tsuruzoe, Masahiro Goto, Keiji Tanaka

    Langmuir   34 ( 25 )   7503 - 7508   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b00641

  • Solvent extraction of Pt(IV), Pd(II), and Rh(III) with the ionic liquid trioctyl(dodecyl) phosphonium chloride 査読

    Mochamad L Firmansyah, Fukiko Kubota, Masahiro Goto

    Journal of Chemical Technology and Biotechnology   93 ( 6 )   1714 - 1721   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jctb.5544

  • Mesoscopic Heterogeneity in Pore Size of Supramolecular Networks 査読

    Yuji Matsumoto, Atsuomi Shundo, Masashi Ohno, Nobutomo Tsuruzoe, Masahiro Goto, Keiji Tanaka

    Langmuir   34 ( 25 )   7503 - 7508   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b00641

  • Mechanistic investigation of transcutaneous protein delivery using solid-in-oil nanodispersion: A case study with phycocyanin. 査読 国際誌

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Momoko Kitaoka, Yoshiro Tahara, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   127   44 - 50   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejpb.2018.01.020

  • Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment 査読

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Molecular Pharmaceutics   15 ( 6 )   2484 - 2488   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.8b00305

  • A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer 査読

    Yusuke Sasaki, Satoru Iwasa, Shunsuke Okazaki, Masahiro Goto, Yasushi Kojima, Atsushi Naganuma, Kengo Nagashima, Yushi Nagai, Hidekazu Hirano, Yoshitaka Honma, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi

    Gastric Cancer   21 ( 3 )   439 - 445   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10120-017-0753-2

  • イオン液体と膜技術の接点を探る イオン液体の経皮吸収促進効果を利用したドラッグデリバリーシステム

    若林里衣, 小坂秀斗, 後藤雅宏

    43 ( 3 )   108‐114   2018年5月

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    記述言語:日本語  

    DOI: 10.5360/membrane.43.108

  • Genipin-stabilized caseinatehitosan nanoparticles for enhanced stability and anti-cancer activity of curcumin 査読

    Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya

    Colloids and Surfaces B: Biointerfaces   164   308 - 315   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2018.01.041

  • Ultra-low thermal conductivity of high-interface density Si/Ge amorphous multilayers 査読

    Masahiro Goto, Yibin Xu, Tianzhuo Zhan, Michiko Sasaki, Chikashi Nishimura, Yohei Kinoshita, Mamoru Ishikiriyama

    Applied Physics Express   11 ( 4 )   2018年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.7567/APEX.11.045202

  • S/O 技術による皮膚浸透促進と化粧品開発 招待

    田原義朗, 後藤雅宏

    月刊ファインケミカル   47 ( 3 )   pp.38 - 44   2018年3月

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  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma 査読

    Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Molecular Pharmaceutics   15 ( 3 )   955 - 961   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.molpharmaceut.7b00894

  • High yield hydrolysis of seaweed-waste biomass using peracetic acid and ionic liquid treatments 査読

    Uju, Agung Tri Wijayanta, Masahiro Goto, Noriho Kamiya

    AIP Conference Proceedings   1931   2018年2月

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

    DOI: 10.1063/1.5024058

  • Formation and characterization of caseinate-chitosan nanocomplexes for encapsulation of Curcumin 査読

    Muhamad Alif Razi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   51 ( 5 )   445 - 453   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.17we293

  • Extraction of rhodium by liquid surfactant membranes containing ionic liquid as a carrier from hydrochloric acid solutions

    Takahiko Kakoi, Kanako Muranaga, Masahiro Goto

    Journal of Chemical Engineering of Japan   51   917 - 920   2018年1月

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    記述言語:その他  

    Extraction of rhodium by liquid surfactant membranes containing ionic liquid as a carrier from hydrochloric acid solutions
    Copyright © 2018 The Society of Chemical Engineers, Japan. Extraction behavior of rhodium (III) with a liquid surfactant membrane (LSM) containing an ionic liquid, 1-octyl-3-me-thylimidazolium hexafluorophosphate ([Omim][PF6]), as a carrier from hydrochloric acid solutions has been investigated. At the optimum conditions, rhodium was selectively extracted over tin by using LSMs in which [Omim][PF6] acted as the mobile carrier. The effects of important operational parameters on the recovery of rhodium were examined with three different stripping reagents for LSMs. It was found that the use of 2-amino-2- hydroxymethyl-1,3-propanediol (Tris) as a stripping reagent in LSMs was the key for the effective extraction of rhodium.

    DOI: 10.1252/jcej.18we086

  • Discontinuous precipitation at the deformation band in copper alloy 査読

    Seung Zeon Han, Jee Hyuk Ahn, Young Soo You, Jehyun Lee, Masahiro Goto, Kwangho Kim, Sangshik Kim

    Metals and Materials International   24 ( 1 )   23 - 27   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12540-017-6626-8

  • Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase 査読

    Mad Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   28 ( 12 )   2954 - 2961   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.bioconjchem.7b00594

  • Production of sophorolipids by Starmerella bombicola yeast using new hydrophobic substrates

    Mansoor Ul Hassan Shah, Magaret Sivapragasam, Muhammad Moniruzzaman, Md. Mahabubur Rahman Talukder, Suzana Bt Yusup, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   127   60 - 67   2017年11月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2017.08.005

  • Related topic: Solid-in-oil technique to increase skin permeation 査読

    Momoko Kitaoka, Masahiro Goto

    Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds   225 - 232   2017年11月

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    記述言語:英語  

    DOI: 10.1007/978-4-431-56526-0_18

  • Evolution of heterogeneity accompanying sol-gel transitions in a supramolecular hydrogel

    Yuji Matsumoto, Atsuomi Shundo, Masashi Ohno, Nobutomo Tsuruzoe, Masahiro Goto, Keiji Tanaka

    SOFT MATTER   13 ( 40 )   7433 - 7440   2017年10月

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    記述言語:英語  

    DOI: 10.1039/c7sm01612c

  • Solubility of acyclovir in nontoxic and biodegradable ionic liquids: COSMO-RS prediction and experimental verification 査読

    Meysam Lotfi, Muhammad Moniruzzaman, Magaret Sivapragasam, Shalini Kandasamy, M. I. Abdul Mutalib, Noorjahan Banu Alitheen, Masahiro Goto

    JOURNAL OF MOLECULAR LIQUIDS   243   124 - 131   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molliq.2017.08.020

  • Transcutaneous immunotherapy of pollinosis using solid-in-oil nanodispersions loaded with T cell epitope peptides 査読

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   529 ( 1-2 )   401 - 409   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2017.07.020

  • Extraction and Stripping Behavior of Platinum Group Metals Using an Amic-Acid-Type Extractant

    Wataru Yoshida, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   50 ( 7 )   521 - 526   2017年7月

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    記述言語:英語  

    DOI: 10.1252/jcej.16we335

  • 経皮吸収製剤における最新のDDS技術 招待

    田原義朗, 後藤雅宏

    DDS先端技術の先端バイオ医薬品への応用開発   8 ( 1 )   pp.404 - 409   2017年6月

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    記述言語:その他  

  • Transcutaneous pollinosis immunotherapy using a solid-in-oil nanodispersion system carrying T cell epitope peptide and R848. 査読 国際誌

    Kitaoka M, Naritomi A, Kawabe Y, Kamihira M, Kamiya N, Goto M

    Bioengineering & translational medicine   2 ( 1 )   102 - 108   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Transcutaneous pollinosis immunotherapy using a solid-in-oil nanodispersion system carrying T cell epitope peptide and R848.
    Antigen-specific immunotherapy is the only curative approach for the treatment of allergic diseases such as Japanese cedar pollinosis. Immunotherapy using a T cell epitope vaccine in combination with the adjuvant R848 is of particular interest as a safe and effective approach to treat allergic diseases. Herein, we propose a simple and easy to handle vaccine administration method using the original solid-in-oil (S/O) nanodispersion system that permeates through the skin. The S/O nanodispersion system is composed of nanoparticles of hydrophilic molecules surrounded with hydrophobic surfactants that are dispersed in an oil vehicle. The system has potential to carry and deliver both hydrophilic and hydrophobic bioactives. Hydrophilic T cell epitope peptide was efficiently delivered through mouse skin using the S/O nanodispersion system and lowered antigen-specific IgE levels in pollinosis model mice. Addition of the hydrophobic adju1vant R848 significantly lowered the antibody secretion and shifted the Th1/Th2-balance toward Th1-type immunity in the model mice, showing the potential to alleviate Japanese cedar pollinosis.

    DOI: 10.1002/btm2.10048

  • Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay 招待 査読 国際誌

    Rie Wakabayashi, Masahiro Goto, Norah Kamiya

    BIOMACROMOLECULES   18 ( 2 )   422 - 430   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01538

  • Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay 査読

    Rie Wakabayashi, Kensuke Yahiro, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    BIOMACROMOLECULES   18 ( 2 )   422 - 430   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01538

  • Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process 査読

    Norasikin Othman, Norul Fatiha Mohamed Noah, Lim Yin Shu, Zing-Yi Ooi, Norela Jusoh, Mariani Idroas, Masahiro Goto

    Chinese Journal of Chemical Engineering   25 ( 1 )   45 - 52   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cjche.2016.06.002

  • Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation 招待 査読 国際誌

    Kousuke Moriyama, Masahiro Goto, Norah Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1452 - 1460   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201600087

  • Solid-in-oil nanodispersions for transdermal drug delivery systems

    Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1375 - 1385   2016年11月

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    記述言語:英語  

    DOI: 10.1002/biot.201600081

  • Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation

    Kousuke Moriyama, Shono Naito, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1452 - 1460   2016年11月

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    記述言語:英語  

    DOI: 10.1002/biot.201600087

  • Development of novel adsorbent bearing aminocarbonylmethylglycine and its application to scandium separation

    Zhigang Zhao, Yuzo Baba, Wataru Yoshida, Fukiko Kubota, Masahiro Goto

    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY   91 ( 11 )   2779 - 2784   2016年11月

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    記述言語:英語  

    DOI: 10.1002/jctb.4884

  • Synergistic degradation of arabinoxylan by free and immobilized xylanases and arabinofuranosidase 招待 査読 国際誌

    Lili Jia, Masahiro Goto, Norah Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   114   271 - 278   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2016.07.013

  • Synergistic degradation of arabinoxylan by free and immobilized xylanases and arabinofuranosidase

    Lili Jia, Geisa A. L. G. Budinova, Yusaku Takasugi, Shuhei Noda, Tsutomu Tanaka, Hirofumi Ichinose, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   114   271 - 278   2016年10月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2016.07.013

  • Diglycolic amic acid-modified E. coli as a biosorbent for the recovery of rare earth elements

    Yukiho Hosomomi, Rie Wakabayashi, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   113   102 - 106   2016年9月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2016.06.005

  • Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass 招待 査読 国際誌

    Uju, Masahiro Goto, Norah Kamiya

    BIORESOURCE TECHNOLOGY   214   487 - 495   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biortech.2016.04.121

  • Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications

    Magaret Sivapragasam, Muhammad Moniruzzaman, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   11 ( 8 )   1000 - 1013   2016年8月

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    記述言語:英語  

    DOI: 10.1002/biot.201500603

  • Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass

    Uju, Masahiro Goto, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   214   487 - 495   2016年8月

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    記述言語:英語  

    DOI: 10.1016/j.biortech.2016.04.121

  • Cu(II)-Imprinted Chitosan Derivative Containing Carboxyl Groups for the Selective Removal of Cu(II) from Aqueous Solution

    Wataru Yoshida, Tatsuya Oshima, Yoshinari Baba, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   49 ( 7 )   630 - 634   2016年7月

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    記述言語:英語  

    DOI: 10.1252/jcej.15we293

  • Enzymatic conjugation of multiple proteins on a DNA aptamer in a tail-specific manner 招待 査読 国際誌

    Mari Takahara, Masahiro Goto, Norah Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 6 )   814 - 823   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201500560

  • Enzymatic conjugation of multiple proteins on a DNA aptamer in a tail-specific manner

    Mari Takahara, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 6 )   814 - 823   2016年6月

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    記述言語:英語  

    DOI: 10.1002/biot.201500560

  • BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells 招待 査読 国際誌

    Akira Tsuchiya, Masahiro Goto, Shinsuke Sando

    ANALYTICAL SCIENCES   32 ( 5 )   543 - 547   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Separation of cobalt(II) from manganese(II) using a polymer inclusion membrane with N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]glycine (D2EHAG) as the extractant/carrier

    Yuzo Baba, Fukiko Kubota, Masahiro Goto, Robert W. Cattrall, Spas D. Kolev

    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY   91 ( 5 )   1320 - 1326   2016年5月

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    記述言語:英語  

    DOI: 10.1002/jctb.4725

  • Ionic liquid pretreatment as emerging approaches for enhanced enzymatic hydrolysis of lignocellulosic biomass

    Amal A. Elgharbawy, Md Zahangir Alam, Muhammad Moniruzzaman, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   109   252 - 267   2016年5月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2016.01.021

  • Biocatalytic Formation of Gold Nanoparticles Decorated with Functional Proteins inside Recombinant Escherichia coli Cells 招待 査読 国際誌

    Yukiho Hosomomi, Masahiro Goto

    ANALYTICAL SCIENCES   32 ( 3 )   295 - 300   2016年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • BODIPY-labeled fluorescent aptamer sensors for turn-on sensing of interferon-gamma and adenine compounds on cells 査読

    Akira Tsuchiya, Siti N. Hashim, Shoko Ise, Takafumi Furuhata, Kiyohiko Kawai, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Shinsuke Sando

    analytical sciences   32 ( 5 )   543 - 547   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.32.543

  • Transcutaneous immunization using nano-sized drug carriers

    Momoko Kitaoka, Masahiro Goto

    Methods in Pharmacology and Toxicology   39   349 - 367   2016年1月

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    Transcutaneous immunization using nano-sized drug carriers
    © Springer Science+Business Media New York 2016. Growing knowledge about the immune system in the skin and recent advances in the preparation of nano-sized particles have encouraged research into the induction of an adaptive immune response via the trans-cutaneous route. Because the skin is abundant in dendritic cell subsets, vaccine administration through the transcutaneous route has promise for simple and efficient immunization and immunotherapy methods, which would provide a welcome alternative to the conventional injection technique. Strategies using a nanoparticle-based protein delivery into the skin depend on the types of nanoparticles, such as soft vesicular nanoparticles, hard inorganic and polymer nanoparticles, and surfactant-coated solid-in-oil nanoparticles. Here, we discuss the skin structure and the immune system in the skin, as well as the types of nanoparticles, routes of administration, and effects of adjuvants. In addition, a detailed description of the preparation and characteristics of solid-in-oil nanoparticles is provided for the future development of an efficient transcutaneous immunization system.

    DOI: 10.1007/978-1-4939-3121-7_18

  • Selective extraction of scandium from transition metals by synergistic extraction with 2-thenoyltrifluoroacetone and tri-n-octylphosphine oxide 査読

    Zhigang Zhao, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   23 ( 2 )   137 - 143   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.23.137

  • Mutual separation of indium, gallium, and zinc with the amic acid-type extractant D2EHAG containing glycine and amide moieties 査読

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   23 ( 1 )   9 - 18   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.23.9

  • Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells 査読

    Yukiho Hosomomi, Teppei Niide, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    analytical sciences   32 ( 3 )   295 - 300   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.32.295

  • Transcutaneous Peptide Immunotherapy of Japanese Cedar Pollinosis Using Solid-in-Oil Nanodispersion Technology

    Momoko Kitaoka, Yoko Shin, Noriho Kamiya, Yoshinori Kawabe, Masamichi Kamihira, Masahiro Goto

    AAPS PHARMSCITECH   16 ( 6 )   1418 - 1424   2015年12月

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    記述言語:英語  

    DOI: 10.1208/s12249-015-0333-x

  • Great potency of seaweed waste biomass from the carrageenan industry for bioethanol production by peracetic acid-ionic liquid pretreatment

    Uju, Agung Tri Wijayanta, Masahiro Goto, Noriho Kamiya

    BIOMASS & BIOENERGY   81   63 - 69   2015年10月

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    記述言語:英語  

    DOI: 10.1016/j.biombioe.2015.05.023

  • Transdermal Immunization using Solid-in-oil Nanodispersion with CpG Oligodeoxynucleotide Adjuvants

    Momoko Kitaoka, Ayaka Naritomi, Yuya Hirakawa, Noriho Kamiya, Masahiro Goto

    PHARMACEUTICAL RESEARCH   32 ( 4 )   1486 - 1492   2015年4月

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    記述言語:英語  

    DOI: 10.1007/s11095-014-1554-5

  • Separation of Gold(III) in Acidic Chloride Solution Using Porous Polymeric Ionic Liquid Gel

    Jian Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   48 ( 3 )   197 - 201   2015年3月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we162

  • Site-specific conjugation of an antibody-binding protein catalyzed by horseradish peroxidase creates a multivalent protein conjugate with high affinity to IgG 査読 国際誌

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   10 ( 1 )   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/biot.201400512

  • Site-specific conjugation of an antibody-binding protein catalyzed by horseradish peroxidase creates a multivalent protein conjugate with high affinity to IgG

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   10 ( 1 )   222 - 226   2015年1月

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    記述言語:英語  

    DOI: 10.1002/biot.201400512

  • Characterization of enzymatically gellable, phenolated linear poly(ethylene glycol) with different molecular weights for encapsulating living cells

    Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   93   25 - 30   2015年1月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2014.09.003

  • Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator

    Akiko Tanaka, Yuld Fukuoka, Yuka Morimoto, Takafumi Honjo, Daisuke Koda, Masahiro Goto, Tatsuo Maruyama

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 2 )   770 - 775   2015年1月

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    記述言語:英語  

    DOI: 10.1021/ja510156v

  • Activity and stability of enzyme immobilized with ionic liquid based polymer materials

    M. Moniruzzaman, H. Mahmood, N. Kamiya, S. Yusup, M. Goto

    Journal of Engineering Science and Technology   10   60 - 69   2015年1月

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    記述言語:その他  

    Activity and stability of enzyme immobilized with ionic liquid based polymer materials
    © School of Engineering, Taylor’s University. Enzyme immobilization methods are continuously being developed for a wide range of applications including biocatalysis and biotransformation. Compared to other immobilization methods, physical entrapment into a matrix is relatively simple and inexpensive, and causes a relatively small perturbation to the native enzyme structure and function. However, significant enzyme leaching from such biocatalytic polymers is the main constraint in using them for industrial levels. This study reports an ionic liquid (IL) polymer materials incorporating enzymes that can be used as active, stable and reusable biocatalysts to overcome the limitations. Lipase was microencapsulated in surfactant aggregates formed in an IL monomer or the solution of an IL monomer/IL and then incorporated into polymer frameworks through the free radical polymerization of an IL (1-vinyl-3-ethylimidazolium bis(trifluoromethylsulfonyl) amide ([veim][Tf2N]). The activity, stability and reusability of IL polymer materials containing lipase were evaluated using lipase-catalyzed hydrolysis of p-nitrophenyl butyrate (p-PNB) as a model reaction. It was found that lipase IL polymer materials exhibited excellent stability in aqueous solutions. More importantly, these biopolymer materials retained most of their activity after six reaction cycles. We firmly believe that enzyme containing IL polymeric materials developed in this study will provide several advantages over conventional polymer based methods for diverse enzymatic reactions.

  • Activity and stability of enzyme immobilized with ionic liquid based polymer materials 査読

    M. Moniruzzaman, H. Mahmood, Noriho Kamiya, S. Yusup, Masahiro Goto

    Journal of Engineering Science and Technology   10   60 - 69   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Characterization of enzymatically gellable, phenolated linear poly(ethylene glycol) with different molecular weights for encapsulating living cells 査読 国際誌

    Kosuke Moriyama, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   93   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2014.09.003

  • Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms 査読 国際誌

    Kosuke Moriyama, Masahiro Goto, Noriho Kamiya

    RSC ADVANCES   5 ( 4 )   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c4ra12334d

  • A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

    Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya, Masahiro Goto

    MEDCHEMCOMM   5 ( 10 )   1515 - 1519   2014年10月

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    記述言語:英語  

    DOI: 10.1039/c4md00179f

  • Supported Liquid Membrane Extraction of Reactive Dye Using Fabricated Polypropylene Membrane

    Norlisa Harruddin, Norasikin Othman, Ani Idris, Zing Yi Ooi, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 10 )   761 - 769   2014年10月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we240

  • Application of cellulose acetate to the selective adsorption and recovery of Au(III)

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    CARBOHYDRATE POLYMERS   111   768 - 774   2014年10月

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    記述言語:英語  

    DOI: 10.1016/j.carbpol.2014.05.003

  • Enzymatic preparation of a redox-responsive hydrogel for encapsulating and releasing living cells 査読 国際誌

    Kosuke Noriyama, Masahiro Goto, Noriho Kamiya

    CHEMICAL COMMUNICATIONS   50 ( 44 )   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c3cc49766f

  • Synergistic Extraction of Rare-Earth Metals and Separation of Scandium Using 2-Thenoyltriuoroacetone and Tri-n-octylphosphine Oxide in an Ionic Liquid System

    Zhigang Zhao, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   656 - 662   2014年8月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we360

  • Separation of Platinum and Palladium from Hydrochloric Acid Solutions with 1-Octyl-3-methylimidazolium Hexafluorophosphate as an Extractant

    Takahiko Kakoi, Mina Kawagoe, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   666 - 670   2014年8月

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    記述言語:英語  

    DOI: 10.1252/jcej.14we052

  • Facile microcapsule fabrication by spray deposition of a supramolecular hydrogel 査読 国際誌

    Atsuomi Shundou, Masahiro Goto, Keiji Tanaka

    RSC ADVANCES   4 ( 68 )   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c4ra04636f

  • Selective adsorption and recovery of precious metal ions using protein-rich biomass as efficient adsorbents

    Tatsuo Maruyama, Yasuki Terashima, Shinano Takeda, Fumiyoshi Okazaki, Masahiro Goto

    PROCESS BIOCHEMISTRY   49 ( 5 )   850 - 857   2014年5月

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    記述言語:英語  

    DOI: 10.1016/j.procbio.2014.02.016

  • Enzymatic self-sacrificial display of an active protein on gold nanoparticles 査読 国際誌

    RSC ADVANCES   4 ( 12 )   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c3ra46384b

  • Highly efficient extraction separation of lanthanides using a diglycolamic acid extractant 査読

    Kojiro Shimojo, Noboru Aoyagi, Takumi Saito, Hiroyuki Okamura, Fukiko Kubota, Masahiro Goto, Hirochika Naganawa

    analytical sciences   30 ( 2 )   263 - 269   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2116/analsci.30.263

  • Highly Efficient Extraction Separation of Lanthanides Using a Diglycolamic Acid Extractant

    Kojiro Shimojo, Noboru Aoyagi, Takumi Saito, Hiroyuki Okamura, Fukiko Kubota, Masahiro Goto, Hirochika Naganawa

    ANALYTICAL SCIENCES   30 ( 2 )   263 - 269   2014年2月

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    記述言語:英語  

    DOI: 10.2116/analsci.30.263

  • Enzymatic self-sacrificial display of an active protein on gold nanoparticles 査読 国際誌

    Masahiro Goto, Teppei Niide, Noriho Kamiya

    RSC ADVANCES   4 ( 12 )   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c3ra46384b

  • Development of Novel Extractants with Amino Acid Structure for Efficient Separation of Nickel and Cobalt from Manganese Ions

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH   53 ( 2 )   812 - 818   2014年1月

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    記述言語:英語  

    DOI: 10.1021/ie403524a

  • Tailing DNA aptamers with a functional protein by two-step enzymatic reaction 査読 国際誌

    Mari Takahara, Masahiro Goto, Noriho Kamiya

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   116 ( 6 )   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jbiosc.2013.05.025

  • Tailing DNA aptamers with a functional protein by two-step enzymatic reaction

    Mari Takahara, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   116 ( 6 )   660 - 665   2013年12月

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    記述言語:英語  

    DOI: 10.1016/j.jbiosc.2013.05.025

  • Needle-free immunization using a solid-in-oil nanodispersion enhanced by a skin-permeable oligoarginine peptide

    Momoko Kitaoka, Kana Imamura, Yuya Hirakawa, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   458 ( 2 )   334 - 339   2013年12月

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    記述言語:英語  

    DOI: 10.1016/j.ijpharm.2013.10.006

  • Enzymatic Fabrication of Protein-Decorated Gold Nanoparticles by the Aid of Artificial Peptides with Gold-Binding Affinity

    Teppei Niide, Kojiro Shimojo, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    LANGMUIR   29 ( 50 )   15596 - 15605   2013年12月

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    記述言語:英語  

    DOI: 10.1021/la401327h

  • Enzymatic Fabrication of Protein-Decorated Gold Nanoparticles by the Aid of Artificial Peptides with Gold-Binding Affinity

    Teppei Niide, Masahiro Goto, Noriho Kamiya

    LANGMUIR   29 ( 50 )   2013年12月

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    記述言語:英語  

    DOI: 10.1021/la401327h

  • Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate 査読

    Hiromu Yoshiura, Miki Tamura, Makoto Aso, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   46 ( 11 )   794 - 796   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.13we009

  • Split Spy0128 as a potent scaffold for protein cross-linking and immobilization 査読 国際誌

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chem.   22   242 - 250   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Biosorption of rare earth elements by Escherichia coli 査読

    Yukiho Hosomomi, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   46 ( 7 )   450 - 454   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.13we031

  • Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol) 査読 国際誌

    Kosuke Moriyama, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   76   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2013.04.007

  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity

    Tatsuya Okuda, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Satoru Kidoaki

    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   24 ( 10 )   1277 - 1290   2013年7月

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    記述言語:英語  

    DOI: 10.1080/09205063.2012.755600

  • Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol)

    Kousuke Moriyama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   76   37 - 42   2013年7月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2013.04.007

  • Spatial Heterogeneity in the Sol-gel Transition of a Supramolecular System 査読 国際誌

    Atsuomi Shundo, Masahiro Goto, Keiji Tanaka

    Soft Matter,   9   5166 - 5172   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol) 査読 国際誌

    Masahiro Goto, Kosuke Moriyama, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   76   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2013.04.007

  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity

    Tatsuaya Okuda, Masahiro Goto, Satoru Kidoaki

    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   24 ( 10 )   2013年7月

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    記述言語:英語  

    DOI: 10.1080/09205063.2012.755600

  • Peracetic acid-ionic liquid pretreatment to enhance enzymatic saccharification of lignocellulosic biomass 査読 国際誌

    Masahiro Goto, Noriho Kamiya, Uju

    BIORESOURCE TECHNOLOGY   138   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biortech.2013.03.147

  • Selective extraction and recovery of rare earth metals from phosphor powders in waste fluorescent lamps using an ionic liquid system

    Fan Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    JOURNAL OF HAZARDOUS MATERIALS   254   79 - 88   2013年6月

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    記述言語:英語  

    DOI: 10.1016/j.jhazmat.2013.03.026

  • Peracetic acid-ionic liquid pretreatment to enhance enzymatic saccharification of lignocellulosic biomass

    Uju, Kojiro Abe, Nobuyuki Uemura, Toyoji Oshima, Masahiro Goto, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   138   87 - 94   2013年6月

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    記述言語:英語  

    DOI: 10.1016/j.biortech.2013.03.147

  • Spatial heterogeneity in the sol-gel transition of a supramolecular system 査読

    David P. Penaloza, Atsuomi Shundo, Keigo Matsumoto, Masashi Ohno, Katsuaki Miyaji, Masahiro Goto, Keiji Tanaka

    Soft Matter   9 ( 21 )   5166 - 5172   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c3sm50225b

  • Low melting point pyridinium ionic liquid pretreatment for enhancing enzymatic saccharification of cellulosic biomass

    Uju, Aya Nakamoto, Yasuhiro Shoda, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Chiaki Ogino, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   135   103 - 108   2013年5月

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    記述言語:英語  

    DOI: 10.1016/j.biortech.2012.06.096

  • 希土類金属の新規吸着剤としての大腸菌の応用

    細樅 侑貴穂, 馬場 雄三, 久保田 富生子, 神谷 典穂, 後藤 雅宏

    希土類 = Rare earths   ( 62 )   176 - 177   2013年5月

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    記述言語:日本語  

  • Protein supramolecular complex formation by site-specific avidin-biotin interactions 査読 国際誌

    Yutaro Mori, Masahiro Goto, Noriho Kamiya

    ORGANIC & BIOMOLECULAR CHEMISTRY   11 ( 6 )   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2ob26625c

  • Enzymatic synthesis of Z-aspartame in liquefied amino acid substrates 査読 国際誌

    Shinya Furukawa, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   70   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bej.2012.10.002

  • Preparation of affnity membranes using thermally induced phase separation for one-step puri?cation of recombinant proteins 査読 国際誌

    T. Monjo, Masahiro Goto, Tatsuo Maruyama

    Anal. Biochem.   434   269 - 274   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Facile and direct synthesis of long-chain chitin from chitobiose via proton-assisted nonaqueous biocatalysis 査読

    Shizuka Egusa, Masahiro Goto, Takuya Kitaoka

    Journal of Molecular Catalysis B: Enzymatic   87   69 - 74   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.molcatb.2012.10.005

  • 薬物漏洩を制御した多層エマルションの調製と経皮吸収促進効果 査読

    安部祐子, 田原義朗, 若林里衣, 神谷典穂, 後藤雅宏

    膜   38 ( 2 )   92 - 96   2013年3月

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    記述言語:日本語  

    A transdermal drug delivery system (TDDS) has attracted much attention due to several advantages over the other administration routes such as injection from the viewpoint of a less harmful method and avoiding first pass through liver. However, its real drug application has been limited to small or lipophilic drugs that can be permeated through the stratum corneum, which has a strong barrier function. Here, we focused on Solid-in-Oil-in-Water (S/O/W) emulsions as a novel TDDS carrier. This technique can encapsulate large hydrophilic molecules such as oligopeptides, proteins and DNAs in the inner oil phase of Oil-in-Water (O/W) emulsion by coating the hydrophilic macromolecules with surfactant molecules. Dispersing hydrophilic macromolecular drugs into the oil phase, S/O/W emulsion containing the hydrophilic drugs can raise the affinity and distribute to the hydrophobic stratum corneum. In this study, we encapsulated hydrophilic macromolecules into S/O/W and investigated the penetration behavior of hydrophilic macromolecules through the skin.

    DOI: 10.5360/membrane.38.92

  • Preparation of affinity membranes using thermally induced phase separation for one-step purification of recombinant proteins

    Takafumi Honjo, Kazuki Hoe, Shunsuke Tabayashi, Tsutomu Tanaka, Josui Shimada, Masahiro Goto, Hideto Matsuyama, Tatsuo Maruyama

    ANALYTICAL BIOCHEMISTRY   434 ( 2 )   269 - 274   2013年3月

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    記述言語:英語  

    DOI: 10.1016/j.ab.2012.11.027

  • Facile and direct synthesis of long-chain chitin from chitobiose via proton-assisted nonaqueous biocatalysis

    Shizuka Egusa, Masahiro Goto, Takuya Kitaoka

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   87   69 - 74   2013年3月

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    記述言語:英語  

    DOI: 10.1016/j.molcatb.2012.10.005

  • Preparation of affinity membranes using thermally induced phase separation for one-step purification of recombinant proteins 査読

    Takafumi Honjo, Kazuki Hoe, Shunsuke Tabayashi, Tsutomu Tanaka, Josui Shimada, Masahiro Goto, Hideto Matsuyama, Tatsuo Maruyama

    Analytical Biochemistry   434 ( 2 )   269 - 274   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ab.2012.11.027

  • Split Spy0128 as a potent scaffold for protein cross-linking and immobilization 査読

    Hiroki Abe, Rie Wakabayashi, Hiroaki Yonemura, Sunao Yamada, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   24 ( 2 )   242 - 250   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/bc300606b

  • 経皮薬物投与を目指したイオン液体製剤の開発 (特集 イオン液体応用技術の新展開)

    麻生 慎, 神谷 典穂, 後藤 雅宏

    化學工業   64 ( 2 )   116 - 121   2013年2月

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    記述言語:日本語  

  • Split Spy0128 as a Potent Scaffold for Protein Cross-Linking and Immobilization

    Hiroki Abe, Rie Wakabayashi, Hiroaki Yonemura, Sunao Yamada, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   24 ( 2 )   242 - 250   2013年2月

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    記述言語:英語  

    DOI: 10.1021/bc300606b

  • Directed aggregation and fusion of vesicles induced by a DNA-surfactant

    M. Goto

    Liaison Functions 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future   24   2013年1月

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    記述言語:その他  

    Directed aggregation and fusion of vesicles induced by a DNA-surfactant

  • Enzymatic synthesis of Z-aspartame in liquefied amino acid substrates

    Shinya Furukawa, Kazuhiro Hasegawa, Ichiro Fuke, Koji Kittaka, Terumitsu Nakakoba, Masahiro Goto, Noriho Kamiya

    Biochemical Engineering Journal   70   84 - 87   2013年1月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2012.10.002

  • A comparative study of ionic liquids and a conventional organic solvent on the extraction of rare-earth ions with TOPO 査読

    Fan Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   20   225 - 232   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.20.225

  • Extraction of rare-earth ions with an 8-hydroxyquinoline derivative in an ionic liquid 査読

    Fan Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   20   123 - 129   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.20.123

  • Low melting point pyridinium ionic liquid pretreatment for enhancing enzymatic saccharification of cellulosic biomass 査読 国際誌

    Uju, Masahiro Goto, Noriho Kamiya

    Bioresource Technology   48   874 - 882   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • レアメタルの今 : 海底資源利用の可能性はあるのか?

    後藤 雅宏

    日本海水学会誌 = Bulletin of the Society of Sea Water Science, Japan   66 ( 6 )   307 - 307   2012年12月

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    記述言語:日本語  

    DOI: 10.11457/swsj.66.307

  • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Masahiro Goto

    MEDCHEMCOMM   3 ( 12 )   1496 - 1499   2012年12月

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    記述言語:英語  

    DOI: 10.1039/c2md20059g

  • Facile and direct synthesis oflong-chain chitinfromchitobiose via proton-assisted nonaqueous biocatalysis 査読 国際誌

    S. Egusa, Masahiro Goto, Takuya Kitaoka

    J. Molecular Catal. B, Enzymatic   87   69 - 74   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Activation of Pyrococcus furiosus alkaline phosphatase by divalent metal ions

    Masahiro Goto, Kosuke Minamihata, Noriho Kamiya

    BIOTECHNOLOGY LETTERS   34 ( 11 )   2012年11月

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    記述言語:英語  

    DOI: 10.1007/s10529-012-0998-0

  • Solid-in-oil dispersion: A novel core technology for drug delivery systems

    Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   438 ( 1-2 )   249 - 257   2012年11月

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    記述言語:英語  

    DOI: 10.1016/j.ijpharm.2012.09.007

  • Activation of Pyrococcus furiosus alkaline phosphatase by divalent metal ions

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY LETTERS   34 ( 11 )   2055 - 2060   2012年11月

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    記述言語:英語  

    DOI: 10.1007/s10529-012-0998-0

  • Solid-in-oil dispersion A novel core technology for drug delivery systems 査読

    Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   438 ( 1-2 )   249 - 257   2012年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2012.09.007

  • Lipase incorporated ionic liquid polymers as active, stable and reusable biocatalysts 査読

    Muhammad Moniruzzaman, Keishirou Ino, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   10 ( 38 )   7707 - 7713   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2ob25529d

  • One-Step Synthesis of Cellulose from Cellobiose via Protic Acid-Assisted Enzymatic Dehydration in Aprotic Organic Media 査読

    S. Egusa, Masahiro Goto, Takuya Kitaoka

    BIOMACROMOLECULES   13 ( 9 )   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/bm3006775

  • Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier

    Fan Yang, Noriho Kamiya, Masahiro Goto

    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS   82 ( 1 )   158 - 163   2012年9月

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    記述言語:英語  

    DOI: 10.1016/j.ejpb.2012.05.016

  • One-Step Synthesis of Cellulose from Cellobiose via Protic Acid-Assisted Enzymatic Dehydration in Aprotic Organic Media

    Shizuka Egusa, Masahiro Goto, Takuya Kitaoka

    BIOMACROMOLECULES   13 ( 9 )   2716 - 2722   2012年9月

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    記述言語:英語  

    DOI: 10.1021/bm3006775

  • Control of a Tyrosyl Radical Mediated Protein Cross-Linking Reaction by Electrostatic Interaction 査読 国際誌

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   23 ( 8 )   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/bc300137s

  • Control of a Tyrosyl Radical Mediated Protein Cross-Linking Reaction by Electrostatic Interaction

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   23 ( 8 )   1600 - 1609   2012年8月

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    記述言語:英語  

    DOI: 10.1021/bc300137s

  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells

    Yoshiro Tahara, Takeshi Kaneko, Riki Toita, Chiharu Yoshiyama, Takuya Kitaoka, Takuro Niidome, Yoshiki Katayama, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CONTROLLED RELEASE   161 ( 3 )   713 - 721   2012年8月

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    記述言語:英語  

    DOI: 10.1016/j.jconrel.2012.05.001

  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells 査読

    Yoshiro Tahara, Takeshi Kaneko, Riki Toita, Chiharu Yoshiyama, Takuya Kitaoka, Takuro Niidome, Yoshiki Katayama, Noriho Kamiya, Masahiro Goto

    Journal of Controlled Release   161 ( 3 )   713 - 721   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jconrel.2012.05.001

  • Facile, rapid and efficient biofabrication of gold nanoparticles decorated with functional proteins 査読 国際誌

    Kojiro Shimojo, Masahiro Goto, Noriho Kamiya

    Analyst.   137   2300 - 2303   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Transglutaminase-Mediated in Situ Hybridization (TransISH) System: A New Methodology for Simplified mRNA Detection

    Momoko Kitaoka, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Hisao Yoshinaga, Koji Nakano, Katsuyuki Miyawaki, Sumihare Noji, Masahiro Goto, Noriho Kamiya

    ANALYTICAL CHEMISTRY   84 ( 14 )   5885 - 5891   2012年7月

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    記述言語:英語  

    DOI: 10.1021/ac2034198

  • Transglutaminase-mediated in situ hybridization (TransISH) system A new methodology for simplified mRNA detection 査読

    Momoko Kitaoka, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Hisao Yoshinaga, Koji Nakano, Katsuyuki Miyawaki, Sumihare Noji, Masahiro Goto, Noriho Kamiya

    Analytical chemistry   84 ( 14 )   5885 - 5891   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/ac2034198

  • Transglutaminase-mediated in situ hybridization (TransISH) system: A new methodology for simplified mRNA detection. 査読 国際誌

    Momoko Kitaoka, Masahiro Goto, Noriho Kamiya

    Anal. Chem   84   5885 - 5891   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Versatile Supramolecular Gelators That Can Harden Water, Organic Solvents and Ionic Liquids

    Nami Minakuchi, Kazuki Hoe, Daisuke Yamaki, Seiichiro Ten-no, Kazunori Nakashima, Masahiro Goto, Minoru Mizuhata, Tatsuo Maruyama

    LANGMUIR   28 ( 25 )   9259 - 9266   2012年6月

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    記述言語:英語  

    DOI: 10.1021/la301442f

  • Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice 査読

    Keisuke Nose, Dakrong Pissuwan, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

    Nanoscale   4 ( 12 )   3776 - 3780   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2nr30651d

  • Versatile Supramolecular Gelators That Can Harden Water, Organic Solvents and Ionic Liquids 査読 国際誌

    Tatsuo Maruyama, Masahiro Goto

    LANGMUIR   28 ( 25 )   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la301442f

  • Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli 査読 国際誌

    T. Niide, M. Goto, N. Kamiya

    Chem. Comm.   47   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 海底資源マンガン団塊からの溶媒抽出法による有価金属の分離

    後藤 雅宏, 馬場 雄三, 久保田 富貴子, 神谷 典穂

    日本海水学会誌 = Bulletin of the Society of Sea Water Science, Japan   66 ( 3 )   131 - 131   2012年5月

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    記述言語:日本語  

  • イオン液体を抽出媒体とした希土類金属の分離特性

    後藤 雅宏, 馬場 雄三, 久保田 富生子, 神谷 典穂

    希土類 = Rare earths   ( 60 )   28 - 29   2012年5月

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    記述言語:日本語  

  • Extraction and separation of rare earth metal ions with DODGAA in ionic liquids 査読

    Fan Yang, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   19   69 - 76   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.19.69

  • Application of ionic liquids for the separation of rare earth metals 査読

    Fukiko Kubota, Yuzo Baba, Masahiro Goto

    Solvent Extraction Research and Development   19   17 - 28   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.19.17

  • Programmable protein-protein conjugation via DNA-based self-assembly 査読

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Hisao Yoshinaga, Koji Nakano, Noriho Kamiya, Masahiro Goto

    Chemical Communications   48 ( 50 )   6226 - 6228   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2cc30618b

  • Facile, rapid and efficient biofabrication of gold nanoparticles decorated with functional proteins 査読

    Kojiro Shimojo, Teppei Niide, Tomitsugu Taguchi, Hirochika Naganawa, Noriho Kamiya, Masahiro Goto

    Analyst   137 ( 10 )   2300 - 2303   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2an35172b

  • Extraction Behavior of Gold from Hydrochloric Acid Solution with Ionic Liquids as Extractants 査読 国際誌

    Takahiko Kakoi, Masahiro Goto

    Solvent Extraction Research and Development, Japan   19   63 - 68   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Short time ionic liquids pretreatment on lignocellulosic biomass to enhance enzymatic saccharification 査読 国際誌

    Uju, Masahiro Goto, Noriho Kamiya

    Bioresour. Technol.   103   446 - 452   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery 査読

    Eiichi Toorisaka, Kikumi Watanabe, Hiroshige Ono, Makoto Hirata, Noriho Kamiya, Masahiro Goto

    Acta Biomaterialia   8 ( 2 )   653 - 658   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.actbio.2011.09.023

  • チロシンタグ導入タンパク質/フェノール性水酸基含有ヒドロゲル融合基材の開発

    境慎司, 足立辰弥, 南畑孝介, 後藤雅宏, 神谷典穂, 川上幸衛, 田谷正仁

    化学工学会年会研究発表講演要旨集(CD-ROM)   77th   ROMBUNNO.A113   2012年2月

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    記述言語:日本語  

  • チロシルラジカルの電荷指向型カップリング反応によるタンパク質架橋

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会年会研究発表講演要旨集(CD-ROM)   77th   ROMBUNNO.B214   2012年2月

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    記述言語:日本語  

  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on histidine-tag chemistry

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    ANALYTICAL BIOCHEMISTRY   421 ( 2 )   541 - 546   2012年2月

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    記述言語:英語  

    DOI: 10.1016/j.ab.2011.11.028

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery

    Eiichi Toorisaka, Kikumi Watanabe, Hiroshige Ono, Makoto Hirata, Noriho Kamiya, Masahiro Goto

    ACTA BIOMATERIALIA   8 ( 2 )   653 - 658   2012年2月

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    記述言語:英語  

    DOI: 10.1016/j.actbio.2011.09.023

  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on histidine-tag chemistry 査読

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   421 ( 2 )   541 - 546   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ab.2011.11.028

  • Short time ionic liquids pretreatment on lignocellulosic biomass to enhance enzymatic saccharification 査読

    Uju, Yasuhiro Shoda, Aya Nakamoto, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Kazunori Nakashima, Chiaki Ogino, Noriho Kamiya

    Bioresource Technology   103 ( 1 )   446 - 452   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biortech.2011.10.003

  • 化学工学会における情報サービス

    後藤 雅宏

    化学工学 = Chemical engineering   76 ( 1 )   1 - 1   2012年1月

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    記述言語:日本語  

  • Short time ionic liquids pretreatment on lignocellulosic biomass to enhance enzymatic saccharification

    Uju, Yasuhiro Shoda, Aya Nakamoto, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Kazunori Nakashima, Chiaki Ogino, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   103 ( 1 )   446 - 452   2012年1月

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    記述言語:英語  

    DOI: 10.1016/j.biortech.2011.10.003

  • Task-specific membranes for the isolation of recombinant proteins with peptide tags 査読

    Tatsuo Maruyama, Shunsuke Tabayashi, Takafumi Honjo, Kazuki Hoe, Tsutomu Tanaka, Josui Shimada, Masahiro Goto, Hideto Matsuyama

    RSC Advances   2 ( 1 )   125 - 127   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c1ra00856k

  • Extraction behavior of gold from hydrochloric acid solutions with ionic liquids as extractants 査読

    Takahiko Kakoi, Mayumi Yoshiyama, Hiroyuki Ariyoshi, Masako Komai, Masahiro Goto

    Solvent Extraction Research and Development   19   63 - 68   2012年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.15261/serdj.19.63

  • Protein lipidation catalyzed by microbial transglutaminase 査読

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   17 ( 50 )   14004 - 14008   2011年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/chem.201102121

  • Protein Lipidation Catalyzed by Microbial Transglutaminase

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    CHEMISTRY-A EUROPEAN JOURNAL   17 ( 50 )   14004 - 14008   2011年12月

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    記述言語:英語  

    DOI: 10.1002/chem.201102121

  • Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation 査読

    Hongyu Piao, Noriho Kamiya, Fude Cui, Masahiro Goto

    International Journal of Pharmaceutics   420 ( 1 )   156 - 160   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijpharm.2011.08.025

  • Protein Heteroconjugation by the Peroxidase-Catalyzed Tyrosine Coupling Reaction

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   22 ( 11 )   2332 - 2338   2011年11月

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    記述言語:英語  

    DOI: 10.1021/bc200420v

  • Preparation of a solid-in-oil nanosuspension containing L-ascorbic acid as a novel long-term stable topical formulation

    Hongyu Piao, Noriho Kamiya, Fude Cui, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   420 ( 1 )   156 - 160   2011年11月

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    記述言語:英語  

    DOI: 10.1016/j.ijpharm.2011.08.025

  • Recent advances in extraction and separation of rare-earth metals using ionic liquids 査読

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   44 ( 10 SPEC. ISSUE )   679 - 685   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1252/jcej.10we279

  • Protein heteroconjugation by the peroxidase-catalyzed tyrosine coupling reaction 査読

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   22 ( 11 )   2332 - 2338   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/bc200420v

  • Transglutaminase-mediated internal protein labeling with a designed peptide loop 査読 国際誌

    Y. Mori, M. Goto, N. Kamiya

    Biochem. Biophys. Res. Commun.   410   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Development of a frequency-domain method using completely optical techniques for measuring the interfacial thermal resistance between the metal film and the substrate 査読

    Ryozo Kato, Yibin Xu, Masahiro Goto

    Japanese Journal of Applied Physics   50 ( 10 )   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.50.106602

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery 査読 国際誌

    E. Toorisaka, K. Watanabe, H. Ono, M. Hirata, N. Kamiya, M. Goto

    Acta Biomaterialia   8   2011年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Molecular assembly-assisted biocatalytic reactions in ionic liquids.

    Muhammad Moniruzzaman, Masahiro Goto

    Methods in molecular biology (Clifton, N.J.)   743   37 - 49   2011年9月

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    記述言語:その他  

    Molecular assembly-assisted biocatalytic reactions in ionic liquids.
    Room temperature ionic liquids (RTILs), having no measurable vapor pressure, represent an interesting class of tunable designer solvents. Due to their many unique properties, ILs have been used as attractive alternatives to environmentally harmful ordinary organic solvents in a wide range of applications including enzymatic biotransformation. Compared to conventional organic solvents, ILs offer many advantages for biocatalysis such as enhanced conversion rates, high enantioselectivity, better enzyme stability, and improved catalyst recoverability and recyclability. However, biocatalysis in ILs has not yet fully achieved its potential because many biocatalysts are insoluble in most ILs. This limitation could be overcome by the formation of nano/micrometer-sized aqueous microemulsion droplets in an IL continuous phase (referred to as water-in-IL microemulsions) stabilized by a layer of surfactants. Enzymes can be dissolved in such water droplets and protected from the unfavorable effect of ILs by the surfactant layer. In this chapter, a simple and effective method for the development of aqueous microemulsion droplets in a hydrophobic IL comprising an anionic surfactant sodium bis(2-ethyl-1-hexyl) sulfosuccinate (AOT) is presented. For this approach, we have synthesized a hydrophobic IL [C(8)mim][Tf(2)N] (1-octyl-3-methyl imidazolium bis(trifluoromethyl sulfonyl) amide) containing a long pendant hydrocarbon chain to facilitate the dissolution of AOT molecules. A detailed description of the procedure for the potential use of this newly developed water-in-IL reverse microemulsion for biocatalysis is also included.

    DOI: 10.1007/978-1-61779-132-1_4

  • Molecular assembly-assisted biocatalytic reactions in ionic liquids. 査読

    Muhammad Moniruzzaman, Masahiro Goto

    Methods in molecular biology (Clifton, N.J.)   743   37 - 49   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/978-1-61779-132-1_4

  • protein assemblies by site-specific avidin-biotin interactions 査読 国際誌

    Y.Mori, K. Minamihata, H. Abe, M. Goto, N. Kamiya

    Org. Biomol. Chem.   9   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation 査読 国際誌

    H. Piao, N. Kamiy, F. Cui, M. Goto

    Int. J. Pharm.   420   2011年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • ストレプトアビジンー酵素ハイブリッドの新規調製法の開発

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)   43rd   ROMBUNNO.P1O054   2011年8月

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    記述言語:日本語  

  • Protein assemblies by site-specific avidin-biotin interactions 査読

    Yutaro Mori, Kosuke Minamihata, Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Organic and Biomolecular Chemistry   9 ( 16 )   5641 - 5644   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c1ob05428g

  • Controllable heterogeneity in a supramolecular hydrogel 査読

    Atsuomi Shundo, Keiko Mizuguchi, Misao Miyamoto, Masahiro Goto, Keiji Tanaka

    Chemical Communications   47 ( 31 )   8844 - 8846   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c1cc12733k

  • Short Time Ionic Liquids Pretreatment On Lignocellulosic Biomass To Enhance Enzymatic Saccharification 査読 国際誌

    Uju, Y. Shoda, A. Nakamoto, M. Goto, W. Tokuhara, Y. Noritake, S. Katahira, N. Ishida, K. Nakashima, C. Ogino, N. Kamiya

    Bioresource Technology   52   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells 査読

    Teppei Niide, Masahiro Goto, Noriho Kamiya

    Chemical Communications   47 ( 26 )   7350 - 7352   2011年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c1cc12302e

  • Task-specific membranes for the isolation of recombinant proteins with peptide-tags 査読 国際誌

    T. Maruyama, S. Tabayashi, T. Honjo, K. Hoe, T. Tanaka, J. Shimada, M. Goto, H. Matsuyama

    RSC Advances   8   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Controllable Heterogeneity in a Supramolecular Hydrogel 査読 国際誌

    A. Shundo, K. Mizuguchi, M. Miyamoto, M. Goto, K. Tanaka

    Chem. Commun.   47 ( 31 )   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium 査読

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   414 ( 1 )   103 - 108   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ab.2011.02.035

  • Transglutaminase-mediated internal protein labeling with a designed peptide loop

    Yutaro Mori, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   410 ( 4 )   829 - 833   2011年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.bbrc.2011.06.073

  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium

    Josui Shimoda, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    ANALYTICAL BIOCHEMISTRY   414 ( 1 )   103 - 108   2011年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.ab.2011.02.035

  • Immobilization of bacterial alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase 査読 国際誌

    K. Moriyama, K. Sung, M. Goto, N. Kamiya

    J. Biosci. Bioeng.   111   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • S/O®技術を用いたタンパク性医薬品の経皮吸収改善と経皮免疫への応用 招待

    後藤雅宏, 田原義朗

    遺伝子医学MOOK別冊 – ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用 –   pp.141 - 147   2011年6月

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    記述言語:その他  

  • Immobilization of alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase

    Kousuke Moriyama, Kyunga Sung, Masahiro Goto, Noriho Kamiya

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   111 ( 6 )   650 - 653   2011年6月

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    記述言語:英語  

    DOI: 10.1016/j.jbiosc.2011.02.002

  • Conjugation of enzymes on RNA probes through Cu(I) catalyzed alkyne-azide cycloaddition 査読 国際誌

    M. Kitaoka, Y. Tanaka, Y. Tada, M. Goto, K. Miyawaki, S. Noji, N. Kamiya

    Biotechnol. J.   7   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • New strategy to enhance catalytic performance of Escherichia coli whole cell biocatalysts harboring P450cam mutants 査読 国際誌

    T. Mouri, N. Kamiya, M. Goto

    53   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • タンパク質の経皮デリバリーは本当に可能か? 招待

    後藤雅宏, 田原義朗

    化学   66   pp.54 - 57   2011年5月

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    記述言語:その他  

  • イオン液体による分離システムの希土類リサイクルへの応用

    久保田 富生子, 馬場 雄三, 神谷 典穂, 後藤 雅宏

    希土類 = Rare earths   ( 58 )   18 - 19   2011年5月

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    記述言語:日本語  

  • Transglutaminase-Mediated Synthesis of a DNA-(Enzyme)(n) Probe for Highly Sensitive DNA Detection

    Momoko Kitaoka, Yukito Tsuruda, Yukari Tanaka, Masahiro Goto, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    CHEMISTRY-A EUROPEAN JOURNAL   17 ( 19 )   5387 - 5392   2011年5月

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    記述言語:英語  

    DOI: 10.1002/chem.201003744

  • Transglutaminase-mediated synthesis of a novel DNA-(enzyme)n probe for highly sensitive DNA detection 査読 国際誌

    M. Kitaoka, Y. Tsuruda, Y. Tanaka, M. Goto, M. Mitsumori, K. Hayashi, Y. Hiraishi, K. Miyawaki, S. Noji, N. Kamiya

    Chem. Eur. J.   17 ( 19 )   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Site-Specific Protein Cross-Linking by Peroxidase-Catalyzed Activation of a Tyrosine-Containing Peptide Tag 査読 国際誌

    K. Minamihata, M. Goto, N. Kamiya

    Bioconjugate Chem.   22   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Conjugation of enzymes on RNA probes through Cu(I) catalyzed alkyne-azide cycloaddition

    Momoko Kitaoka, Yukari Tanaka, Yutaka Tada, Masahiro Goto, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   6 ( 4 )   470 - 476   2011年4月

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    記述言語:英語  

    DOI: 10.1002/biot.201000249

  • Solid–in–Oil(S/O®)製剤技術を利用したオイルゲルシート 査読

    船津麻美, 田原義朗, 山中桜子, 後藤雅宏

    膜   36 ( 2 )   57 - 62   2011年3月

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    記述言語:日本語  

    In this article, we report a novel oil gel sheet, which is contained ascorbic acid and hyaluronic acid as an ingredient of cosmetics. An efficient permeation method of the ingredients into a deep skin would be a key technology to develop novel functional cosmetics. The outer surface of the skin that is stratum corneum has a strong barrier to avoid the invasion of hazardous materials into our body. The barrier function causes the difficulty in the transport of effective ingredients into a deep region of our skin. To overcome this problem, solid-in-oil (S/O) nano dispersion technique has been developed by coating the ingredients with hydrophobic surfactant molecules. The coated hyaluronic acid was well dispersed in an oil phase and its permeation rate into the skin was significantly enhanced by the formation of the complex. An oil gel sheet was created by utilizing the S/O techniques for ascorbic acid and hyaluronic acid. The oil gel sheet could improve the moisture condition of faces by using at least 30 minutes.

    DOI: 10.5360/membrane.36.57

  • チロシン酸化反応を用いた異種タンパク質架橋体の酵素合成

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会年会研究発表講演要旨集(CD-ROM)   76th   ROMBUNNO.A318   2011年2月

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    記述言語:日本語  

  • 九州大学大学院工学研究院応用化学部門バイオプロセス化学講座

    後藤 雅宏, 神谷 典穂

    化学工学 = Chemical engineering   75 ( 2 )   96 - 96   2011年2月

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    記述言語:日本語  

  • A Solid-in-Oil Dispersion of Gold Nanorods Can Enhance Transdermal Protein Delivery and Skin Vaccination

    Dakrong Pissuwan, Keisuke Nose, Ryohsuke Kurihara, Kenji Kaneko, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

    SMALL   7 ( 2 )   215 - 220   2011年1月

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    記述言語:英語  

    DOI: 10.1002/smll.201001394

  • Site-Specific Protein Cross-Linking by Peroxidase-Catalyzed Activation of a Tyrosine-Containing Peptide Tag

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   22 ( 1 )   74 - 81   2011年1月

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    記述言語:英語  

    DOI: 10.1021/bc1003982

  • New strategy to enhance catalytic performance of Escherichia coli whole cell biocatalysts harboring P450cam mutants

    Tsuyoshi Mouri, Noriho Karniya, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   53 ( 2 )   229 - 233   2011年1月

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    記述言語:英語  

    DOI: 10.1016/j.bej.2010.09.016

  • Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state

    Masafumi Sakono, Konomi Motomura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   404 ( 1 )   494 - 497   2011年1月

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    記述言語:英語  

    DOI: 10.1016/j.bbrc.2010.12.009

  • Ionic liquid based microemulsion with pharmaceutically accepted components: Formulation and potential applications

    Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    JOURNAL OF COLLOID AND INTERFACE SCIENCE   352 ( 1 )   136 - 142   2010年12月

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    記述言語:英語  

    DOI: 10.1016/j.jcis.2010.08.035

  • Preparation and enzymatic behavior of surfactant-enveloped enzymes for glycosynthesis in nonaqueous aprotic media

    Shizuka Egusa, Takuya Kitaoka, Kiyohiko Igarashi, Masahiro Samejima, Masahiro Goto, Hiroyuki Wariishi

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   67 ( 3-4 )   225 - 230   2010年12月

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    記述言語:英語  

    DOI: 10.1016/j.molcatb.2010.08.010

  • Fluorogenic Ribonuclease Protection (FRIP) Analysis of Single Nucleotide Polymorphisms (SNPs) in Japanese Rice (Oryza sativa L.) DNA for Cultivar Discrimination

    Momoko Kitaoka, Takuya Wada, Takeshi Nishio, Masahiro Goto

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   74 ( 11 )   2189 - 2193   2010年11月

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    記述言語:英語  

    DOI: 10.1271/bbb.100351

  • 新規カチオン性ダブルコーティング型キャリアによる遺伝子デリバリー

    田原義朗, 金子丈志, 戸井田力, 神谷典穂, 新留琢郎, 片山佳樹, 後藤雅宏

    日本バイオマテリアル学会大会予稿集   32nd   192   2010年11月

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    記述言語:日本語  

  • 廃家電品からの希土類元素のリサイクル : その現状と将来

    後藤 雅宏

    希土類 = Rare earths   ( 57 )   37 - 42   2010年11月

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    記述言語:日本語  

  • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation

    Muhammad Moniruzzaman, Miki Tamura, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   400 ( 1-2 )   243 - 250   2010年11月

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    記述言語:英語  

    DOI: 10.1016/j.ijpharm.2010.08.034

  • 海水は将来の金属資源となり得るか?

    後藤 雅宏

    日本海水学会誌   64 ( 5 )   243 - 243   2010年10月

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    記述言語:日本語  

  • Ionic Liquid Based Microemulsion with Pharmaceutically Accepted Components: Formulation and Potential Applications 査読 国際誌

    M. Moniruzzaman, N. Kamiya, M. Goto

    Journal of Colloid & Interface Science   352   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • One-Step Lactosylation of Hydrophobic Alcohols by Nonaqueous Biocatalysis

    Yuri Okutani, Shizuka Egusa, Yukiko Ogawa, Takuya Kitaoka, Masahiro Goto, Hiroyuki Wariishi

    CHEMCATCHEM   2 ( 8 )   950 - 952   2010年8月

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    記述言語:英語  

    DOI: 10.1002/cctc.201000051

  • 部位特異的タンパク質修飾のための高反応性トランスグルタミナーゼ基質ペプチド配列の探索

    尾上佳大, 神谷典穂, 南畑孝介, 安倍弘喜, 後藤雅宏

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)   42nd   ROMBUNNO.L1P60   2010年8月

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    記述言語:日本語  

  • ファージディスプレイ法