Updated on 2024/10/09

Information

 

写真a

 
KAMIYA NORIHO
 
Organization
Faculty of Engineering Department of Applied Chemistry Professor
Faculty of Agriculture Insect Science and Creative Entomology Center(Concurrent)

Center for Future Chemistry (Concurrent)
School of Engineering (Concurrent)
Graduate School of Engineering (Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0928022807
Profile
My research interest is focused on enzyme and protein engineering to create new protein-based biomaterials. To fully exploit the unique functions of proteins, different strategies including genetic engineering, enzyme engineering and organic synthesis should be combined, and my research is actually directed in this direction. I am now interested in post-translational, site-specific modification of functional proteins to design new nanobioarchitectures for specific functions. I am also interested in drug delivery systems for oral and transdermal administration of pharmaceutical peptides and proteins, and next-generation biopharmaceuticals such as antibody-drug conjugates. During my research, I have collaborated with many industrial companies and founded KAICO Ltd, a start-up company from Kyushu University, in collaboration with the Department of Agriculture (Prof. Kusakabe's group). In terms of education, after completing my Ph.D., I experienced two universities, University of Tokyo & MIT, and had two undergraduate classes at the former. I spent one year at MIT as a visiting scientist and worked on the project related to protein drug delivery and protein chip technology. Now I am involved in many kinds of lectures and work at the university.
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Research Areas

  • Nanotechnology/Materials / Bio chemistry

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering

Degree

  • Doctor of Engineering

Research History

  • KAICO Ltd.

    2018.7 - Present

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  • Kyushu University Center for Future Chem. & Dept. Applied Chem. Professor

    2010.12 - Present

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  • - Associate Professor, Department of Applied Chemistry,

    2002

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  • 1998.4-2001.9 東京大学大学院工学系研究科 化学生命工学専攻 2001.10-2002.9 Massachusetts Institute of Technology, Department of Chemistry(日本学術振興会海外特別研究員)

  • University of Tokyo

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  • Kyushu University

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Education

  • Kyushu University   Graduate School, Division of Engineering

    - 1998

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  • Kyushu University   Faculty of Engineering

    - 1994

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Research Interests・Research Keywords

  • Research theme:Site-specific modification

    Keyword:Site-specific modification

    Research period: 2024

  • Research theme:Lipidized proteins

    Keyword:Lipidized proteins

    Research period: 2024

  • Research theme:Enzymes in post-translational modification

    Keyword:Enzymes in post-translational modification

    Research period: 2024

  • Research theme:Enzyme engineering

    Keyword:Enzyme engineering

    Research period: 2024

  • Research theme:Biomolecular engineering

    Keyword:Biomolecular engineering

    Research period: 2024

  • Research theme:Biopharmaceutics

    Keyword:Biopharmaceutics

    Research period: 2024

  • Research theme:Biomaterials

    Keyword:Biomaterials

    Research period: 2024

  • Research theme:Hydrogel

    Keyword:Hydrogel

    Research period: 2024

  • Research theme:protein engineering

    Keyword:protein engineering

    Research period: 2024

  • Research theme:Protein expression by silkworm

    Keyword:Protein expression by silkworm

    Research period: 2024

  • Research theme:Development of next generation biopharmaceuticals including antibody-drug conjugates

    Keyword:antibody-drug conjugate, site-specific labeling, antibody fragment

    Research period: 2021.4 - 2026.3

  • Research theme:Development of easy-to-handle hydrogel compartments for single-cell analyses

    Keyword:single cell culture, single cell analysis, hydrogel beads

    Research period: 2020.4 - 2027.3

  • Research theme:Development of lipid-protein conjugates and exploration of their potential applications

    Keyword:lipid-protein conjugate, artificial lipidized protein

    Research period: 2018.4 - 2027.3

  • Research theme:Development of easy-to-handle compartments for biomolecular systems

    Keyword:directed evolution, cell culture, proliferation

    Research period: 2017.4 - 2026.3

  • Research theme:Basic research and design concept for insect biorefinery with silkworm in Kyushu University and its application

    Keyword:biorefinery, insect engineering

    Research period: 2013.10 - 2025.3

  • Research theme:Design, creation and evaluation of supramolecular protein complexes.

    Keyword:scaffold molecule, cellulosome, protein hybrid molecule

    Research period: 2013.4 - 2021.3

  • Research theme:Development of novel transdermal protein drug delivery systems

    Keyword:protein drug delivery, pharmaceutical formulation, oral administration, vaccine

    Research period: 2012.4 - 2018.3

  • Research theme:Biocatalytic oxidation/reduction system in recombinant E. coli cells for the production of protein-decorated nano particles

    Keyword:protein engineering, enzyme engineering, metal nanoparticle

    Research period: 2011.4 - 2016.3

  • Research theme:Development of novel nucleic acid-enzyme hybrid systems

    Keyword:enzyme-DNA hybrid, in situ hybridization, Genomic southern blot

    Research period: 2007.4 - 2013.3

  • Research theme:New biocatalytic systems based on the use of ionic liquids

    Keyword:enzyme engineering, biocatalysis, ionic liquid, biorefinery

    Research period: 2006.4 - 2013.3

  • Research theme:Biocatalytic oxidation/reduction system in recombinant E. coli cells

    Keyword:protein engineering, enzyme engineering, P450, Au nanoparticle

    Research period: 2005.4 - 2011.3

  • Research theme:Development of new protein drug delivery systems

    Keyword:protein drug delivery, pharmaceutical formulation, oral administration, vaccine

    Research period: 2003.4 - 2011.3

  • Research theme:Protein engineering with post-translational protein modifying enzymes

    Keyword:enzymatic protein engineering, site-specific modification, transglutaminase

    Research period: 2002.4 - 2012.3

Awards

  • 第16回 生物工学功績賞

    2022.8   日本生物工学会   酵素触媒架橋反応を利用した生体分子工学分野の開拓に関する研究

  • 第16回 生物工学功績賞

    2022.8   日本生物工学会   酵素触媒架橋反応を利用した生体分子工学分野の開拓に関する研究

    神谷 典穂

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  • 第20回酵素応用シンポジウム研究奨励賞

    2019.6   一般財団法人 天野エンザイム科学技術振興財団   人工基質による翻訳後修飾を介した新たなタンパク質機能の開拓

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    酵素触媒を利用した様々なタイプの融合タンパク質の設計に対する業績に対して奨励賞を授与された。

  • 平成30年度化学工学会研究賞

    2019.3   化学工学会   生体触媒を利用した生体分子工学に関する研究

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    化学・医薬・食品といった産業分野では、利用目的に応じて高度に機能化された触媒が強く求められている。温和な反応条件下、多彩な化学変換を触媒する生体触媒は、持続可能な社会の構築に向けたものづくりの担い手として、広くその重要性が認識されている。本教員は、反応工学的発想に有機化学と遺伝子工学のエッセンスを加え、生体触媒を駆使することで初めて可能になるバイオプロセス・バイオアッセイ系の構築を志向し、化学と工学を融合した多彩な技術と方法論の提案に向けた研究開発を進め、平成30年度化学工学会研究賞(玉置明善記念賞)を授与された。

  • 第22回 日本生物工学会論文賞

    2014.9   日本生物工学会   日本生物工学会英文誌 J. Biosci. Bioeng. 論文賞

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    本論文では,タンパク質とオリゴ核酸の部位特異的な連結法として,2種類の酵素反応を組み合わせた新しい技術を報告している.具体的には,DNAアプタマーを部位特異的にアルカリホスファターゼに連結し,さらにトロンビン結合性アプタマーを用いてトロンビンの高感度検出を達成し,本研究で提案する2種類の酵素を介したタンパク質-オリゴ核酸コンジュゲートの新規調製法の有用性を実証した.実験の設計ならびに結果の解釈まで,非常に分かり易く纏められている点も評価できる.一般的に,化学修飾法ではタンパク質と核酸を部位特異的に連結することが困難であるが,2種類の酵素反応を組み合せることで,簡便迅速な末端ラベル法を確立している点に,本研究のオリジナリティがある.また,原理的にはあらゆる核酸と酵素の組合せに応用可能であることから,今後バイオエンジニアリング分野で幅広く利用される基礎技術になり得ると考えられる.

  • Honorable Mention Award

    2013.9   Poster Competition in Enzyme Engineering XXII   機能性タンパク質の部位特異的且つ共有結合的修飾のための酵素基質エンジニアリング

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    本論文は、異種生体分子を酵素反応を用いて部位特異的にアセンブルする技術の基礎研究から応用に至る展開を発表したものである。意図する機能を発現するための分子設計指針から、特異な構造を有する生体分子の調製、得られたハイブリッド分子による高感度遺伝子検出試薬の実用化(JST育成研究成果)とセルロース系バイオマス分解触媒としての利用価値(JST-ALCA研究成果)について言及した。

  • 平成24年度 九州大学研究・産学官連携活動表彰

    2012.5   九州大学  

  • The Best Presentation Award at APBioChEC'09

    2009.11   Organizing Committee of APBioChEC'09   New fluorescent substrates designed for covalent protein labeling catalyzed by microbial transglutaminase

  • 平成21年度 九州大学研究・産学官連携活動表彰

    2009.5   九州大学  

  • The Best Poster Paper Award in APBioChEC'07

    2007.11   APBioChEC'07 organizing committe  

  • 平成19年度 九州大学研究・産学官連携活動表彰

    2007.5   九州大学  

  • 平成18年度日本生物工学会論文賞

    2006.9   日本生物工学会   日本生物工学会の英文誌 J. Biosci. Bioeng. の優秀論文賞

  • 平成17年度酵素工学奨励賞

    2005.5   酵素工学研究会   翻訳後修飾酵素を利用したタンパク質の高機能化とその応用に関する研究

  • 平成15年度化学工学会奨励賞

    2004.3   化学工学会   酵素の翻訳後修飾機能を利用した機能性融合タンパク質調製法の開発

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Papers

  • Engineering the Propeptide of Microbial Transglutaminase Zymogen: Enabling Substrate-Dependent Activation for Bioconjugation Applications. International journal

    #Ryutaro Ariyoshi, #Takashi Matsuzaki, #Ryo Sato, Kosuke Minamihata, Kounosuke Hayashi, Taisei Koga, Kensei Orita, Riko Nishioka, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Bioconjugate chemistry   35 ( 3 )   340 - 350   2024.2   ISSN:1043-1802 eISSN:1520-4812

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    Microbial transglutaminase (MTG) from Streptomyces mobaraensis is a powerful biocatalytic glue for site-specific cross-linking of a range of biomolecules and synthetic molecules that have an MTG-reactive moiety. The preparation of active recombinant MTG requires post-translational proteolytic digestion of a propeptide that functions as an intramolecular chaperone to assist the correct folding of the MTG zymogen (MTGz) in the biosynthesis. Herein, we report engineered active zymogen of MTG (EzMTG) that is expressed in soluble form in the host Escherichia coli cytosol and exhibits cross-linking activity without limited proteolysis of the propeptide. We found that the saturation mutagenesis of residues K10 or Y12 in the propeptide domain generated several active MTGz mutants. In particular, the K10D/Y12G mutant exhibited catalytic activity comparable to that of mature MTG. However, the expression level was low, possibly because of decreased chaperone activity and/or the promiscuous substrate specificity of MTG, which is potentially harmful to the host cells. The K10R/Y12A mutant exhibited specific substrate-dependent reactivity toward peptidyl substrates. Quantitative analysis of the binding affinity of the mutated propeptides to the active site of MTG suggested an inverse relationship between the binding affinity and the catalytic activity of EzMTG. Our proof-of-concept study provides insights into the design of a new biocatalyst using the MTGz as a scaffold and a potential route to high-throughput screening of EzMTG mutants for bioconjugation applications.

    DOI: 10.1021/acs.bioconjchem.3c00544

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  • A Functional Hydrogel Bead-Based High-Throughput Screening System for Mammalian Cells with Enhanced Secretion of Therapeutic Antibodies. International journal

    #Diah Anggraini Wulandari, #Kyosuke Tsuru, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Biomaterials Science & Engineering   10 ( 1 )   628 - 636   2024.1   ISSN:2373-9878

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    Droplet-based high-throughput screening systems are an emerging technology that provides a quick test to screen millions of cells with distinctive characteristics. Biopharmaceuticals, specifically therapeutic proteins, are produced by culturing cells that secrete heterologous recombinant proteins with different populations and expression levels; therefore, a technology to discriminate cells that produce more target proteins is needed. Here, we present a droplet-based microfluidic strategy for encapsulating, screening, and selecting target cells with redox-responsive hydrogel beads (HBs). As a proof-of-concept study, we demonstrate the enrichment of hybridoma cells with enhanced capability of antibody secretion using horseradish peroxidase (HRP)-catalyzed hydrogelation of tetra-thiolate poly(ethylene glycol); hybridoma cells were encapsulated in disulfide-bonded HBs. Recombinant protein G or protein M with a C-terminal cysteine residue was installed in the HBs via disulfide bonding to capture antibodies secreted from the cells. HBs were fluorescently stained by adding the protein L-HRP conjugate using a tyramide signal amplification system. HBs were then separated by fluorescence-activated droplet sorting and degraded by reducing the disulfide bonds to recover the target cells. Finally, we succeeded in the selection of hybridoma cells with enhanced antibody secretion, indicating the potential of this system in the therapeutic protein production.

    DOI: 10.1021/acsbiomaterials.3c01386

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  • Preparation of amphotericin B-loaded hybrid liposomes and the integration of chitin-binding proteins for enhanced antifungal activity Invited Reviewed International journal

    #Pugoh Santoso, #Takuya Komada, Yugo Ishimine, #Hiromasa Taniguchi, @Kosuke Minamihata, @Masahiro Goto, Toki Taira, @Noriho Kamiya

    Journal of Bioscience and Bioengineering   134 ( 3 )   259 - 263   2022.9   ISSN:1389-1723 eISSN:1347-4421

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    DOI: 10.1016/j.jbiosc.2022.06.005

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  • Liposomal Amphotericin B Formulation Displaying Lipid-Modified Chitin-Binding Domains with Enhanced Antifungal Activity Invited Reviewed International journal

    #Hiromasa Taniguchi, Yugo Ishimime, @Kosuke Minamihata, #Pugoh Santoso, #Takuya Komada, #Hendra Saputra, #Kazuki Uchida, @Masahiro Goto, Toki Taira, @Noriho Kamiya

    Molecular Pharmaceutics   19 ( 11 )   3906 - 3914   2022.9   ISSN:1543-8384 eISSN:1543-8392

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    Fungal infections affect more than one billion people worldwide and cause more than one million deaths per year. Amphotericin B (AmB), a polyene antifungal drug, has been used as the gold standard for many years because of its broad antifungal spectrum, high activity, and low tendency of drug resistance. However, the side effects of AmB, such as nephrotoxicity and hepatotoxicity, have hampered its widespread use, leading to the development of a liposome-type AmB formulation, AmBisome. Herein, we report a simple but highly effective strategy to enhance the antifungal activity of AmBisome with a lipid-modified protein. The chitin-binding domain (LysM) of the antifungal chitinase, Pteris ryukyuensis chitinase A (PrChiA), a small 5.3 kDa protein that binds to fungal cell wall chitin, was engineered to have a glutamine-containing peptide tag at the C-terminus for the microbial transglutaminase (MTG)-catalyzed crosslinking reaction (LysM-Q). LysM-Q was site-specifically modified with a lysine-containing lipid peptide substrate of MTG with a palmitoyl moiety (Pal-K). The resulting palmitoylated LysM (LysM-Pal) exhibited negligible cytotoxicity to mammalian cells and can be easily anchored to yield LysM-presenting AmBisome (LysM-AmBisome). LysM-AmBisome exhibited a dramatic enhancement of antifungal activity toward Trichoderma viride and Cryptococcus neoformans, demonstrating the marked impact of displaying a cell-wall binder protein on the targeting ability of antifungal liposomal formulations. Our simple strategy with enzymatic protein lipidation provides a potent approach to upgrade other types of lipid-based drug formulations.

    DOI: 10.1021/acs.molpharmaceut.2c00388

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  • Artificial Palmitoylation of Proteins Controls the Lipid Domain-Selective Anchoring on Biomembranes and the Raft-Dependent Cellular Internalization Invited Reviewed International journal

    #Kazuki Uchida, #Hiroki Obayashi, @Kosuke Minamihata, @Rie Wakabayashi, @Masahiro Goto, Naofumi Shimokawa, Masahiro Takagi, @Noriho Kamiya

    Langmuir   38 ( 31 )   9640 - 9648   2022.8   ISSN:0743-7463 eISSN:1520-5827

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    Protein palmitoylation, a post-translational modification, is universally observed in eukaryotic cells. The localization of palmitoylated proteins to highly dynamic, sphingolipid- and cholesterol-rich microdomains (called lipid rafts) on the plasma membrane has been shown to play an important role in signal transduction in cells. However, this complex biological system is not yet completely understood. Here, we used a combined approach where an artificial lipidated protein was applied to biomimetic model membranes and plasma membranes in cells to illuminate chemical and physiological properties of the rafts. Using cell-sized giant unilamellar vesicles, we demonstrated the selective partitioning of enhanced green fluorescent protein modified with a C-terminal palmitoyl moiety (EGFP-Pal) into the liquid-ordered phase consisting of saturated phospholipids and cholesterol. Using Jurkat T cells treated with an immunostimulant (concanavalin A), we observed the vesicular transport of EGFP-Pal. Further cellular studies with the treatment of methyl beta-cyclodextrin revealed the cholesterol-dependent internalization of EGFP-Pal, which can be explained by a raft-dependent, caveolae-mediated endocytic pathway. The present synthetic approach using artificial and natural membrane systems can be further extended to explore the potential utility of artificially lipidated proteins at biological and artificial interfaces.

    DOI: 10.1021/acs.langmuir.2c01205

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  • Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B Invited Reviewed International journal

    #Pugoh Santoso, @Kosuke Minamihata, @Yugo Ishimine, #Hiromasa Taniguchi, #Takuya Komada, #Ryo Sato, @Masahiro Goto, @Tomoya Takashima, @Toki Taira, @Noriho Kamiya

    ACS Infectious Diseases   8 ( 5 )   1051 - 1061   2022.4

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    DOI: https://doi.org/10.1021/acsinfecdis.2c00052

  • Recent advances in research on biointerfaces: From cell surfaces to artificial interfaces Invited Reviewed International journal

    Hori, Katsutoshi; Yoshimoto, Shogo; Yoshino, Tomoko; Zako, Tamotsu; Hirao, Gen; Fujita, Satoshi; Nakamura, Chikashi; Yamagishi, Ayana; Kamiya, Noriho

    J. Biosci. Bioeng.   133 ( 3 )   195 - 207   2022.3   ISSN:1389-1723 eISSN:1347-4421

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    DOI: 10.1016/j.jbiosc.2021.12.004

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  • Orthogonal Enzymatic Conjugation Reactions Create Chitin Binding Domain Grafted Chitinase Polymers with Enhanced Antifungal Activity Reviewed International journal

    @K. Minamihata, #Y. Tanaka, #P. Santoso, @M. Goto, #D. Kozome, @T. Taira, @N. Kamiya

    Bioconjugate Chem.   32 ( 8 )   1688 - 1698   2021.8

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    DOI: 10.1021/acs.bioconjchem.1c00235

  • Recombinant production of active microbial transglutaminase in E. coli by using self-cleavable zymogen with mutated propeptide Reviewed

    Ryo Sato, Kosuke Minamihata, Ryutaro Ariyoshi, Hiromasa Taniguchi, Noriho Kamiya

    Protein Expression and Purification   2020.12

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    DOI: 10.1016/j.pep.2020.105730

  • Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids Reviewed

    Wahyu Ramadhan, Yuki Ohama, Kosuke Minamihata, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   130 ( 4 )   416 - 423   2020.10

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    DOI: 10.1016/j.jbiosc.2020.05.010

  • Dual-Functionalizable Streptavidin–SpyCatcher-Fused Protein–Polymer Hydrogels as Scaffolds for Cell Culture Reviewed

    3   7734 - 7742   2020.10

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    DOI: https://doi.org/10.1021/acsabm.0c00940

  • Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel Reviewed

    Wahyu Ramadhan, Genki Kagawa, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Scientific reports   10 ( 1 )   2020.5

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    DOI: 10.1038/s41598-020-63362-4

  • Synthetic Strategies for Artificial Lipidation of Functional Proteins Reviewed

    Mari Takahara, Noriho Kamiya

    Chemistry - A European Journal   26 ( 21 )   4645 - 4655   2020.4

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    DOI: 10.1002/chem.201904568

  • Linear Polymerization of Protein by Sterically Controlled Enzymatic Cross-Linking with a Tyrosine-Containing Peptide Loop Reviewed

    Dani Permana, Kosuke Minamihata, Ryo Sato, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS Omega   5 ( 10 )   5160 - 5169   2020.3

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    DOI: 10.1021/acsomega.9b04163

  • Poly(ethylene glycol)-based biofunctional hydrogels mediated by peroxidase-catalyzed cross-linking reactions Reviewed

    Rie Wakabayashi, Wahyu Ramadhan, Kousuke Moriyama, Masahiro Goto, Noriho Kamiya

    Polymer Journal   2020.1

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    DOI: 10.1038/s41428-020-0344-7

  • PolyTag A peptide tag that affords scaffold-less covalent protein assembly catalyzed by microbial transglutaminase Reviewed

    R. Sato, K. Minamihata, R. Wakabayashi, M. Goto, N. Kamiya

    Analytical Biochemistry   2020.1

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    DOI: 10.1016/j.ab.2020.113700

  • Enzymatically Prepared Dual Functionalized Hydrogels with Gelatin and Heparin to Facilitate Cellular Attachment and Proliferation Reviewed

    Wahyu Ramadhan, Genki Kagawa, Yusei Hamada, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   2 ( 6 )   2600 - 2609   2019.6

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    DOI: 10.1021/acsabm.9b00275

  • Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates Reviewed International journal

    Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   25 ( 30 )   7315 - 7321   2019.5

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    DOI: 10.1002/chem.201900370

  • Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery Reviewed

    Muhamad Alif Razi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Langmuir   35 ( 7 )   2610 - 2618   2019.2

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    DOI: 10.1021/acs.langmuir.8b02809

  • Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control Reviewed International journal

    Rie Wakabayashi, Ayumi Suehiro, Masahiro Goto, Noriho Kamiya

    Chemical Communications   55 ( 5 )   640 - 643   2019.1

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    DOI: 10.1039/C8CC08163H

  • Liquid Marbles as an Easy-to-Handle Compartment for Cell-Free Synthesis and In Situ Immobilization of Recombinant Proteins Invited Reviewed International journal

    Noriho Kamiya, Yuki Ohama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto

    Biotechnology Journal   13 ( 12 )   2018.12

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    DOI: 10.1002/biot.201800085

  • Design of Lipid-Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase Reviewed International journal

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS App. Bio Mater.   1 ( 6 )   1823 - 1829   2018.10

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    DOI: 10.1021/acsabm.8b00271

  • Mechanistic investigation of transcutaneous protein delivery using solid-in-oil nanodispersion A case study with phycocyanin Reviewed

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Momoko Kitaoka, Yoshiro Tahara, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    European Journal of Pharmaceutics and Biopharmaceutics   127   44 - 50   2018.6

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    DOI: 10.1016/j.ejpb.2018.01.020

  • Expression and Activation of Horseradish Peroxidase–Protein A/G Fusion Protein in Silkworm Larvae for Diagnostic Purposes Reviewed

    13   1700624   2018.6

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    DOI: 10.1002/biot.201700624

  • Genipin-stabilized caseinatehitosan nanoparticles for enhanced stability and anti-cancer activity of curcumin Reviewed

    Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya

    Colloids and Surfaces B: Biointerfaces   164   308 - 315   2018.4

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    DOI: 10.1016/j.colsurfb.2018.01.041

  • Polymeric SpyCatcher Scaffold Enables Bioconjugation in a Ratio-Controllable Manner Reviewed

    Lili Jia, Kosuke Minamihata, Hirofumi Ichinose, Kouhei Tsumoto, Noriho Kamiya

    Biotechnology Journal   12 ( 12 )   2017.12

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    DOI: 10.1002/biot.201700195

  • Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase Reviewed

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   28 ( 12 )   2954 - 2961   2017.12

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    DOI: 10.1021/acs.bioconjchem.7b00594

  • Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation Reviewed International journal

    Moriyama, Kousuke, Naito, Shono, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1452 - 1460   2016.11

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    DOI: 10.1002/biot.201600087

  • Salt-Switchable Artificial Cellulase Regulated by a DNA Aptamer Reviewed International journal

    Takahara, Mari, Budinova, Geisa Aparecida Lopes Goncalves, Nakazawa, Hikaru, Mori, Yutaro, Umetsu, Mitsuo, Kamiya, Noriho

    BIOMACROMOLECULES   17 ( 10 )   3356 - 3362   2016.10

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    DOI: 10.1021/acs.biomac.6b01141

  • One-dimensional assembly of functional proteins: toward the design of an artificial cellulosome Reviewed International journal

    Mori, Yutaro, Budinova, Geisa Aparecida Lopes Goncalves, Nakazawa, Hikaru, Umetsu, Mitsuo, Kamiya, Noriho

    Mol. Syst. Des. Eng.   1 ( 1 )   66 - 73   2016.4

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    DOI: 10.1039/C6ME90005D

  • Biocatalytic Formation of Gold Nanoparticles Decorated with Functional Proteins inside Recombinant Escherichia coli Cells Invited Reviewed International journal

    Yukiho HOSOMOMI, Teppei NIIDE, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ANALYTICAL SCIENCES   32 ( 3 )   295 - 300   2016.3

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  • Heme precursor injection is effective for Arthromyces ramosus peroxidase fusion protein production by a silkworm expression system Reviewed International journal

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   120 ( 4 )   384 - 386   2015.10

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    DOI: 10.1016/j.jbiosc.2015.02.013

  • Effect of pretreatment methods on the synergism of cellulase and xylanase during the hydrolysis of bagasse Reviewed International journal

    BIORESOURCE TECHNOLOGY   185   158 - 164   2015.6

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    DOI: 10.1016/j.biortech.2015.02.041

  • Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms Reviewed International journal

    RSC ADVANCES   5 ( 4 )   2015.3

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    DOI: 10.1039/c4ra12334d

  • Characterization of Enzymatically Gellable, Phenolated Linear Poly(Ethylene Glycol) with Different Molecular Weights for Encapsulating Living Cells Reviewed International journal

    BIOCHEMICAL ENGINEERING JOURNAL   93   2015.1

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  • Site-specific conjugation of an antibody-binding protein catalyzed by horseradish peroxidase creates a multivalent protein conjugate with high affinity to IgG Reviewed International journal

    BIOTECHNOLOGY JOURNAL   10 ( 1 )   2015.1

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    DOI: 10.1002/biot.201400512

  • Enzymatic preparation of a redox-responsive hydrogel for encapsulating and releasing living cells Reviewed International journal

    CHEMICAL COMMUNICATIONS   50 ( 44 )   2014.8

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    DOI: 10.1039/c3cc49766f

  • Enzymatic self-sacrificial display of an active protein on gold nanoparticles Reviewed International journal

    RSC ADVANCES   4 ( 12 )   2014.4

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    DOI: 10.1039/c3ra46384b

  • Protein lipidation catalyzed by microbial transglutaminase Reviewed International journal

    H. Abe, M. Goto, N. Kamiya

    Chem. Eur. J.   17   2011.12

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  • Protein heteroconjugation by the peroxidase-catalyzed tyrosine coupling reaction Reviewed International journal

    K. Minamihata, M. Goto, N. Kamiya

    Bioconjugate Chem.   22   2011.12

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  • Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells Reviewed International journal

    T. Niide, M. Goto, N. Kamiya

    Chem. Commun.   47   2011.5

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  • Protein assemblies by site-specific avidin-biotin interactions Reviewed International journal

    Y. Mori, K. Minamihata, H. Abe, M. Goto, N. Kamiya

    Org. Biomol. Chem.   9   2011.5

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  • Transglutaminase-mediated internal protein labeling with a designed peptide loop Reviewed International journal

    Y. Mori, M. Goto, N. Kamiya

    Biochem. Biophys. Res. Commun.   410   2011.5

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  • Site-specific protein cross-linking by peroxidase-catalyzed activation of a tyrosine-containing peptide tag Reviewed International journal

    K. Minamihata, M. Goto, N. Kamiya

    Bioconjugate Chem.   22   2011.4

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  • Immobilization of alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase Reviewed International journal

    K. Moriyama, K. Sung, M. Goto, N. Kamiya

    J. Biosci. Bioeng.   111   2011.4

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  • Transglutaminase-mediated synthesis of a novel DNA-(enzyme)n probe for highly sensitive DNA detection Reviewed International journal

    M. Kitaoka, Y. Tsuruda, Y. Tanaka, M. Goto, M. Mitsumori, K. Hayashi, Y. Hiraishi, K. Miyawaki, S. Noji, N. Kamiya

    Chem. Eur. J.   19   2011.3

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  • Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase Reviewed International journal

    T. Mouri, T. Shimizu, N. Kamiya,* H. Ichinose, M. Goto*

    Biotechnol. Prog.   25   2009.10

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  • Stimuli-responsive nanoparticles composed of naturally occurring amphiphilic proteins Reviewed International journal

    N. Kamiya,* Y. Shiotari, M. Tokunaga, H. Matsunaga, H. Yamanouchi, K. Nakano, M. Goto

    Chem. Commun.   2009.8

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  • Fluorescent substrates for covalent protein labeling catalyzed by microbial transglutaminase Reviewed International journal

    N. Kamiya,* H. Abe, M. Goto, Y. Tsuji, H. Jikuya

    Org. Biomol. Chem.   7   2009.8

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  • Development of a novel immobilization method for enzymes from hyperthermophiles Reviewed International journal

    K. Minamihata, N. Kamiya,* S. Kiyoyama, H. Sakuraba, T. Ohshima, M. Goto

    Biotechnol. Lett.   2009.7

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  • A solid-in-oil nanodispersion for transcutaneous protein delivery Reviewed International journal

    Y. Tahara, S. Honda, N. Kamiya, H. Piao, A. Hirata, E. Hayakawa, T. Fujii, M. Goto

    J. Contrl. Rel.   2008.7

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  • Enzymatic in situ saccharification of cellulose in aqueous-ionic liquid media. Reviewed International journal

    N. Kamiya, Y. Matsushita, M. Hanaki, K. Nakashima, M. Narita, M. Goto, H. Takahashi

    Biotechnol. Lett.   2008.6

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  • Water-in-Ionic Liquid Microemulsions as a New Medium for Enzymatic Reactions Reviewed International journal

    M.M.Zaman, K. Nakashima, N. Kamiya, M. Goto

    Green Chem.   2008.5

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  • Spectrophotometric assay for protease activity in ionic liquids using chromogenic substrates Reviewed International journal

    K. Nakashima, N. Kamiya, T. Maruyama, M. Goto

    Anal. Biochem.   2008.3

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  • Formation of reversed micelles in a room temperature ionic liquid. Reviewed International journal

    M.M.Zaman, K. Nakashima, N. Kamiya, M. Goto

    ChemPhysChem   2008.3

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  • Functional immobilization of recombinant alkaline phosphatases bearing a glutamyl donor substrate peptide of microbial transglutaminase Reviewed International journal

    N. Kamiya, S. Doi, Y. Tanaka, H. Ichinose, M. Goto

    J. Biosci. Bioeng.   2007.9

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  • Intramolecular electron transfer in a cytochrome P450cam system with a site-specific branched structure Reviewed International journal

    H. Hirakawa, N. Kamiya, T. Tanaka, T. Nagamune

    Protein Eng. Des. Sel.   2007.9

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  • Exploring enzymatic catalysis at a solid surface: a case study with transglutaminase-mediated protein immobilization Reviewed International journal

    Y. Tanaka, Y. Tsuruda, M. Nishi, N. Kamiya, M. Goto

    Org. Biomol. Chem.   2007.5

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  • An enzyme-labeled protein polymer bearing pendant haptens Reviewed International journal

    J. Tominaga, N. Kamiya, M. Goto

    Bioconjugate Chem.   2007.3

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  • Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol) Reviewed International journal

    K. Nakashima, T. Maruyama, N. Kamiya, M. Goto

    Sci. Technol. Adv. Mater.   2007.1

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  • An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides Reviewed International journal

    J. Tominaga, Y. Kemori, Y. Tanaka, T. Maruyama, N. Kamiya, M. Goto

    Chem. Commun.   2007.1

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  • Oral delivery of diclofenac sodium using a novel solid-in-oil suspension Reviewed International journal

    H. Piao, N. Kamiya, J. Watanabe, H. Yokoyama, A. Hirata, T. Fujii, I. Shimizu, S. Ito, M. Goto

    Int. J. Pharm.   2006.11

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  • Homogeneous Enzymatic Reaction in Ionic Liquids with Poly(ethylene glycol)-Modified Subtilisin Reviewed International journal

    K. Nakashima, T. Maruyama, N. Kamiya, M. Goto

    Org. Biomol. Chem.   2006.10

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  • Increasing the catalytic performance of a whole cell biocatalyst harboring a cytochrome P450cam system by stabilization of an electron transfer component Reviewed International journal

    T.Mouri, N.Kamiya, M.Goto

    Biotechnol. Lett.   2006.5

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  • A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration Reviewed International journal

    T.Mouri, J.Michizoe, H.Ichinose, N.Kamiya, M.Goto

    Appl. Microbiol. Biotechnol.   2006.4

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  • N-terminal glycine-specific protein conjugation catalyzed by microbial transglutaminase Reviewed International journal

    T.Tanaka, N. Kamiya, T.Nagamune

    FEBS Letter   579 ( 10 )   2092 - 2096   2005.1

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    DOI: 10.1016/j.febslet.2005.02.064

  • Design of a specific peptide tag that affords covalent and site-specific enzyme immobilization catalyzed by microbial transglutaminase Reviewed International journal

    J. Tominaga, N. Kamiya, S. Doi, H. Ichinose, T. Maruyama, M. Goto

    Biomacromolecules   6 ( 4 )   2299 - 2304   2005.1

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    DOI: 10.1021/bm050193o

  • Transglutaminase-mediated protein immobilization to casein nanolayers created on a plastic surface Reviewed International journal

    N.Kamiya, S.Doi, J.Tominaga, H.Ichinose, M.Goto

    Biomacromolecules   6 ( 1 )   35 - 38   2005.1

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    DOI: 10.1021/bm0494895

  • Transglutaminase-mediated proximity labeling of a specific Lys residue in a native IgG antibody

    Nishioka, R; Iida, R; Minamihata, K; Sato, R; Kimura, M; Kamiya, N

    CHEMICAL COMMUNICATIONS   60 ( 65 )   8545 - 8548   2024.8   ISSN:1359-7345 eISSN:1364-548X

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    The fusion protein of an engineered zymogen of microbial transglutaminase (EzMTG) with a protein G variant, EzMTG-pG, enabled the proximity-based, tag-free labeling of Lys65 in the heavy chain of a native IgG antibody (trastuzumab) with a Gln-donor peptidyl substrate functionalized with a fluorescent molecule.

    DOI: 10.1039/d4cc01728e

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  • Sustainable Synthesis of Cellulose Nanofibers from Industrial Agar Seaweed Waste Biomass Using Hydrated Deep Eutectic Solvents

    Hardiningtyas, SD; Putra, BU; Anggara, KB; Yuniasani, I; Ramadhan, W; Pari, RF; Uju; Hastuti, N; Indrawan, DA; Wakabayashi, R; Goto, M; Kamiya, N

    WASTE AND BIOMASS VALORIZATION   15 ( 8 )   4899 - 4913   2024.8   ISSN:1877-2641 eISSN:1877-265X

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    Purpose: This work evaluated the profiles of Industrial agar seaweed waste biomass (ISWB) and pretreated ISWB by using deep eutectic solvent (DESs) and NaOH. The profiles of nanocellulose obtained from pretreated ISWB (with various types of hydrogen bond donors of choline chloride (ChCl)-based hydrated DES) were also evaluated. Methods: ISWB underwent pre-treatment with either 100% wt. DES (1:1 molar ratio of ethylene glycol: citric acid) or 10% wt. NaOH at 80 °C to 90 °C. Subsequent treatment involved 10% wt. DES or ChCl-based hydrated DES with various HBDs (oxalic acid, citric acid, and urea) in a 1:2 molar ratio to produce nanocellulose. Results: Cellulose nanofibers isolated by the CE-DES approach exhibited a substantially higher yield compared with those obtained via the CE-NaOH method. CE-DES method induced swelling of ISWB and facilitate production of cellulose nanofibers. SEM images of samples indicates the presence of fibrous nanostructures across the majority of the specimens. Fourier-transform infrared (FTIR) spectroscopy demonstrated uniformity among all samples; they exhibited a consistent fingerprint pattern. X-ray diffraction (XRD) spectra indicated the presence of cellulose Type I in cellulose nanofibers produced by CE–DES, but not definitively in nanocellulose produced by the CE–NaOH method. Conclusion: Cellulose nanofibers can be isolated from ISWB by using various DES and exhibits substantial characteristics of cellulose nanofibers from different ISWB pretreatment protocols. Graphical Abstract: (Figure presented.)

    DOI: 10.1007/s12649-024-02499-z

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  • Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

    Islam, R; Nabila, FH; Wakabayashi, R; Kawaguchi, Y; Kamiya, N; Moniruzzaman, M; Goto, M

    MOLECULES   29 ( 13 )   2024.7   eISSN:1420-3049

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    Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.

    DOI: 10.3390/molecules29132995

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  • Design and validation of functionalized redox-responsive hydrogel beads for high-throughput screening of antibody-secreting mammalian cells

    Diah Anggraini Wulandari, Kyosuke Tsuru, Kosuke Minamihata, Rie Wakabayashi, Go Egami, Yoshinori Kawabe, Masamichi Kamihira, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   138 ( 1 )   89 - 95   2024.7   ISSN:1389-1723 eISSN:1347-4421

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    DOI: 10.1016/j.jbiosc.2024.04.001

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  • Design and validation of functionalized redox-responsive hydrogel beads for high-throughput screening of antibody-secreting mammalian cells(タイトル和訳中)

    Wulandari Diah Anggraini, Tsuru Kyosuke, Minamihata Kosuke, Wakabayashi Rie, Egami Go, Kawabe Yoshinori, Kamihira Masamichi, Goto Masahiro, Kamiya Noriho

    Journal of Bioscience and Bioengineering   138 ( 1 )   89 - 95   2024.7   ISSN:1389-1723

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  • Prospecting <i>Ulva lactuca</i> seaweed in Java Island, Indonesia, as a candidate resource for industrial applications

    Pari, RF; Uju; Wijayanta, AT; Ramadhan, W; Hardiningtyas, SD; Kurnia, KA; Firmansyah, ML; Hana, A; Abrar, MN; Wakabayashi, R; Kamiya, N; Goto, M

    FISHERIES SCIENCE   90 ( 5 )   795 - 808   2024.6   ISSN:0919-9268 eISSN:1444-2906

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    Ulva is an unutilized green seaweed that grows in the intertidal zone around the coast of Java Island, Indonesia. In this study, U. lactuca samples collected from three regions in south of Java Island (Cihara, Surade, and Tepus) were studied in terms of their chemical composition, physical properties and its bioactivity, to determine the best regions for establishing seaweed industries. The chemical characteristics differed significantly among different regions, where the seaweed from Tepus, Surade and Cihara had the highest content of protein (22.93%), carbohydrate (61.58%), and mineral (28.72%), respectively. The amino acids were dominated with L-aspartic acid and L-glutamic acid. All U. lactuca samples contained abundant pigments, such as chlorophylls and carotenoids, especially samples from Tepus. The highest content of crude ulvan was found in Surade seaweed (26.9%). Chemical and physical analyses showed the presence of S = O and C–O–S functional groups in ulvan, a sulfated polysaccharide unique to Ulva sp., with thermal degradation up to 220 °C. Crude ulvan from Surade and Tepus seaweed exhibited bioactivity to support proliferation of fibroblast cells at 100 and 1000 ppm, respectively. Based on the properties of U. lactuca, Tepus and Surade were identified as potential sites to establish aquaculture and/or processing industries.

    DOI: 10.1007/s12562-024-01799-6

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  • Facilitating Ulvan Extraction from Ulva lactuca via Deep Eutectic Solvent and Peracetic Acid Treatment

    Ramadhan W., Alamsyah A.D., Uju , Hardiningtyas S.D., Pari R.F., Wakabayashi R., Kamiya N., Goto M.

    ASEAN Journal of Chemical Engineering   24 ( 1 )   90 - 101   2024.4   ISSN:16554418

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    Ulva lactuca is a green seaweed commonly called sea lettuce and contains sulphated polysaccharides that have biological activity. Despite its lack of ecological sustainability, strong acids (HCl) and strong bases (NaOH) are widely used as solvents in the conventional extraction process for ulvan. Deep eutectic solvent (DES) is an alternative to ulvan extraction solvent, which is more environmentally friendly and has low toxicity. This study aims to assess the efficacy of peracetic acid (PAA) pretreatment and post-treatment in enhancing the quality of extracted ulvan using a DES-based solvent in the extraction process. Ulvan extraction using DES with a temperature of 85-95°C for 1 hour and adding 2% PAA pretreatment, 0.1%, 0.5%, and 2% PAA post-treatment were conducted. PAA pre-and post-treatment was carried out with a 1:10 (w/v) ratio at room temperature for 30 minutes. The analysis included moisture content, yield, functional groups, sulphate content, and color. The test results revealed that ulvan treated with 2% PAA pretreatment had the highest moisture content and sulphate content, at 18.71% and 33.39%, respectively, while ulvan treated with 0.1% PAA post-treatment had the highest yield, at 41.96%. Adding peracetic acid concentration can increase the color quality of the ulvan. PAA pre-and post-treatment had a significant effect on all ulvan quality parameters.

    DOI: 10.22146/ajche.12272

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  • Ionic liquid-mediated ethosome for transdermal delivery of insulin. International journal

    Fahmida Habib Nabila, Rashedul Islam, Islam Md Shimul, Muhammad Moniruzzaman, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Chemical communications (Cambridge, England)   60 ( 30 )   4036 - 4039   2024.3   ISSN:1359-7345 eISSN:1364-548X

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    Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.

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  • Exploring the molecular structure of lipids in the design of artificial lipidated antifungal proteins

    Hendra Saputra, Muhammad Safaat, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira, Noriho Kamiya

    2024.3

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    DOI: 10.1101/2024.03.04.583322

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  • Ionic Liquid-Based patch formulation for enhanced transdermal delivery of sparingly soluble drug

    Rashedul Islam, Fahmida Habib Nabila, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   397   2024.3   ISSN:0167-7322 eISSN:1873-3166

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    Ionic liquid (IL)-based transdermal formulations have gained significant attention because of their high skin penetration efficiency and ease of design. However, many IL-based formulations exhibit low viscosity, which hinders direct administration and leads to less efficient drug delivery. Therefore, there is a pressing need for specialized formulations with improved viscosity and efficacy as a drug delivery platform. In this study, we report a ready-to-use transdermal patch system utilizing IL-in-oil (IL/O) microemulsions to deliver acyclovir, a sparingly soluble antiviral drug. To prepare the patch system, a mixture containing equal weights of IL/O microemulsions and adhesive (Durotak 87–4098) was homogenized, subsequently coated on a liner, and covered by a support film. These patches were produced with varying thicknesses (100 μm, 200 μm, 300 μm, and 500 μm) via a solvent evaporation technique. A 24-hour in vitro skin permeation study revealed that the thinnest patch (100 μm) delivered more than 45 % of the loaded drug. Drug delivery rate gradually reduced as the patch thickness increased, accounting for 22 % and 14 % drug permeation by 200 μm and 300 μm patches respectively. A 30-day stability study at room temperature demonstrated that neither the physical appearance nor the active ingredient content changed, validating the physical and chemical stability of the patches. Skin permeation mechanism by Fourier transform infrared spectroscopic analysis of the skin suggested that the IL/O patch possesses the capability to modify the lipid barrier in the stratum corneum thus facilitating drug diffusion. In vitro skin irritation studies on reconstructed human epidermal tissue and Yucatan micropig skin revealed that the patch exhibits no skin irritation. We believe that the adhesive nature of this newly developed IL-based patch holds significant promise as a transdermal drug delivery platform.

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  • Orthogonality of α-Sulfoquinovosidase in Human Cells and Development of Its Fluorescent Substrate

    Ryosuke Yoshida, Ryosei Kaguma, Ryosuke Kaneko, Ichiro Matuso, Makoto Yoritate, Go Hirai, Takamasa Teramoto, Yoshimitsu Kakuta, Kosuke Minamihata, Noriho Kamiya, Teruki Nii, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

    Sensors and Materials   36 ( 8 )   3227 - 3238   2024   ISSN:0914-4935 eISSN:2435-0869

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  • Characterization of enzyme-crosslinked albumin hydrogel for cell encapsulation(タイトル和訳中)

    Moriyama Kousuke, Inomoto Noe, Moriuchi Hidetoshi, Nihei Masanobu, Sato Miku, Miyagi Yoshiki, Tajiri Ayaka, Sato Takeshi, Tanaka Yasuhiko, Johno Yuuki, Goto Masahiro, Kamiya Noriho

    Journal of Bioscience and Bioengineering   136 ( 6 )   471 - 476   2023.12   ISSN:1389-1723

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    ペルオキシダーゼ触媒によるクロスリンク形成を介して生理的な条件下でゲル化を受けるアルブミン派生物を合成した。アルブミンをカルボジイミドを用いてフェノール性水酸基(Alb-Ph-OH)で修飾し、置換度がゲル化に及ぼす影響を解析した。Alb-Ph-OHヒドロゲルの多様な特性、すなわち、ゲル化時間、膨張率、孔径、貯蔵弾性率、および酵素的な分解性は置換度とポリマー濃度の調整により容易に調節可能であった。Alb-Ph-OHヒドロゲル中にカプセル化された細胞の生存率は高かった。

  • Engineered Active Zymogen of Microbial Transglutaminase

    Ryutaro Ariyoshi, Takashi Matsuzaki, Ryo Sato, Kosuke Minamihata, Kounosuke Hayashi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

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  • Characterization of enzyme-crosslinked albumin hydrogel for cell encapsulation

    Kousuke Moriyama, Noe Inomoto, Hidetoshi Moriuchi, Masanobu Nihei, Miku Sato, Yoshiki Miyagi, Ayaka Tajiri, Takeshi Sato, Yasuhiko Tanaka, Yuuki Johno, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   136 ( 6 )   471 - 476   2023.10   ISSN:1389-1723 eISSN:1347-4421

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  • Engineered Active Zymogen of Microbial Transglutaminase International journal

    Ryutaro Ariyoshi, Takashi Matsuzaki, Ryo Sato, Kosuke Minamihata, Kounosuke Hayashi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    bioRxiv preprint doi: https://doi.org/10.1101/2023.10.09.561484   2023.9

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  • Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids

    Kiyohiro Toyofuku, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    ACS Applied Materials & Interfaces   15 ( 28 )   33299 - 33308   2023.7   ISSN:1944-8244 eISSN:1944-8252

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  • Enzymatic Fabrication of Multifunctional Amyloid-based Protein Assembly

    Mitsuki Nakamura, Ryoichi Arai, Noriho Kamiya, Masafumi Sakono

    Chemistry Letters   52 ( 7 )   538 - 541   2023.7   ISSN:0366-7022 eISSN:1348-0715

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  • One-pot synthesis of fibrillar-shaped functional nanomaterial using microbial transglutaminase

    Masafumi Sakono, Mitsuki Nakamura, Tatsuki Ohshima, Ayano Miyakoshi, Ryoichi Arai, Kosuke Minamihata, Noriho Kamiya

    Journal of Bioscience and Bioengineering   135 ( 6 )   440 - 446   2023.6   ISSN:1389-1723 eISSN:1347-4421

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  • Research on biomolecular engineering using enzyme-catalyzed crosslinking reactions

    Kamiya Noriho

    Seibutsu-kogaku Kaishi   101 ( 3 )   117 - 122   2023.3   ISSN:09193758 eISSN:24358630

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  • Transdermal Transmission Blocking Vaccine for Malaria using a Solid-in-Oil Dispersion

    Keisuke Tanaka, Kosuke Minamihata, Rie Wakabayashi, Jae Man Lee, Takeshi Miyata, Takahiro Kusakabe, Noriho Kamiya, Masahiro Goto

    Journal of Pharmaceutical Sciences   112 ( 2 )   411 - 415   2023.2   ISSN:0022-3549 eISSN:1520-6017

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    Malaria is a mosquito-borne infectious disease that is widespread in developing countries. Malaria vaccines are important in efforts to eradicate malaria; however, vaccines are usually administered by injection, which requires medical personnel and has a risk of causing infection. Transdermal vaccines can be administered without damaging the skin and thus are ideal for the prevention of malaria. However, the stratum corneum forms a "brick and mortar" like structure in which stratum corneum cells are embedded in a hydrophobic matrix composed of lipids, which strongly inhibits the permeation of hydrophilic substances. In the present study, we designed a transdermal vaccine against vivax malaria using a solid-in-oil (S/O) dispersion. The S/O dispersion of a transmission blocking vaccine candidate, Pvs25 from Plasmodium vivax, showed higher skin penetration than that of the aqueous solution. Mice immunized with the S/O dispersion generated antibodies at similar titers as the mice immunized by injection, over the mid- to long-term. These results provide information for the development of transdermally administered malaria vaccines toward the eradication of malaria.

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  • Supramolecular localization in liquid-liquid phase separation and protein recruitment in confined droplets

    Hiroki Obayashi, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Chemical Communications   59 ( 4 )   414 - 417   2023.1   ISSN:1359-7345 eISSN:1364-548X

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    This study investigated the localization of artificial peptide supramolecular fibers in liquid-liquid phase separation (LLPS). Hierarchical organization led to the localization of supramolecules in LLPS droplets. Moreover, proteins were recruited into confined droplets by the physical adsorption of proteins on the supramolecules, enabling an enhanced cascade reaction.

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  • Molecular crowding elicits the acceleration of enzymatic crosslinking of macromolecular substrates

    Ryo Sato, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Organic and Biomolecular Chemistry   21 ( 2 )   306 - 314   2023.1   ISSN:1477-0520 eISSN:1477-0539

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    Cytoplasm contains high concentrations of biomacromolecules. Protein behavior under such crowded conditions is reportedly different from that in an aqueous buffer solution, mainly owing to the effect of volume exclusion caused by the presence of macromolecules. Using a crosslinking reaction catalyzed by microbial transglutaminase (MTG) as a model, we herein systematically determined how the substrate size affects enzymatic activity in both dilute and crowded solutions of dextran. We first observed a threefold reduction in MTG-mediated crosslinking of a pair of small peptide substrates in 15 wt% dextran solution. In contrast, when proteinaceous substrates were involved, the crosslinking rates in 15 wt% dextran solutions accelerated markedly to levels comparable with the level in the absence of dextran. Our results provide new insights into the action of enzymes with regard to macromolecular substrates under crowded conditions, of which the potential utility was demonstrated by the formation of highly crosslinked protein polymers.

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  • TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation. Invited Reviewed International journal

    @Kato Y, @Nishiyama K, @Lee JM, @Ibuki Y, @Imai Y, @Noda T, @Kamiya N, @Kusakabe T, @Kanda Y, @Nishida M.

    International Journal of Molecular Sciences   24 ( 1 )   2022.12   ISSN:1661-6596 eISSN:1422-0067

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    Myocardial damage caused by the newly emerged coronavirus (SARS-CoV-2) infection is one of the key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host cells is initiated by binding with its receptor, angiotensin-converting enzyme (ACE) 2, and the ACE2 abundance is thought to reflect the susceptibility to infection. Here, we report that ibudilast, which we previously identified as a potent inhibitor of protein complex between transient receptor potential canonical (TRPC) 3 and NADPH oxidase (Nox) 2, attenuates the SARS-CoV-2 spike glycoprotein pseudovirus-evoked contractile and metabolic dysfunctions of neonatal rat cardiomyocytes (NRCMs). Epidemiologically reported risk factors of severe COVID-19, including cigarette sidestream smoke (CSS) and anti-cancer drug treatment, commonly upregulate ACE2 expression level, and these were suppressed by inhibiting TRPC3-Nox2 complex formation. Exposure of NRCMs to SARS-CoV-2 pseudovirus, as well as CSS and doxorubicin (Dox), induces ATP release through pannexin-1 hemi-channels, and this ATP release potentiates pseudovirus entry to NRCMs and human iPS cell-derived cardiomyocytes (hiPS-CMs). As the pseudovirus entry followed by production of reactive oxygen species was attenuated by inhibiting TRPC3-Nox2 complex in hiPS-CMs, we suggest that TRPC3-Nox2 complex formation triggered by panexin1-mediated ATP release participates in exacerbation of myocardial damage by amplifying ACE2-dependent SARS-CoV-2 entry.

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  • Choline oleate based micellar system as a new approach for Luteolin formulation: Antioxidant, antimicrobial, and food preservation properties evaluation

    Shimul, IM; Moshikur, RM; Minamihata, K; Moniruzzaman, M; Kamiya, N; Goto, M

    JOURNAL OF MOLECULAR LIQUIDS   365   2022.11   ISSN:0167-7322 eISSN:1873-3166

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    Luteolin (LUT), an important flavonoid, shows excellent antioxidant and antimicrobial properties. However, its low solubility and stability in water, as well as challenges related to its formulation, have limited its use in food preservation. Here, we develop a highly water-soluble LUT-loaded micellar formulation (LUT-MF) using a solid-in-water nanodispersion technique involving emulsification and lyophilization processes. LUT solubilized in an organic phase comprising acetone, methanol, and cyclohexane (5:10:85 v/v) was emulsified with an aqueous solution of a surface-active ionic liquid, choline oleate ([Cho][Ole]), and the oil in water emulsion was lyophilized to remove the organic phase and water and obtain a solid LUT-[Cho][Ole] complex. LUT-[Cho][Ole] complex was dispersed again in water to prepare the LUT-MF formulation with good stability. Dynamic light scattering and transmission electron microscopy confirmed that the LUT-MF formed spherical micelles with a mean particle size of approximately 73 nm. LUT-MF showed excellent encapsulation efficiency (94.3%) and enhanced aqueous solubility. An in vitro release study in PBS containing 30% ethanol demonstrated 3.94 times higher release of LUT from LUT-MF than from LUT suspension after 24 h. The developed formulation showed better antioxidant activity than both free LUT and ascorbic acid. LUT-MF demonstrated higher antibacterial activity than sodium benzoate. Food preservation studies revealed that treating strawberries with LUT-MF effectively preserved color and prevented shriveling and decay over 8 days storage at 10 °C, compared with sodium benzoate treatment. The results suggest that LUT-MF is a potential natural preservative alternative to conventional toxic chemical preservatives used in the food industry.

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  • 抗真菌活性強化のためのアンフォテリシンB含有ハイブリッドリポソームの調製とキチン結合蛋白質の統合(Preparation of amphotericin B-loaded hybrid liposomes and the integration of chitin-binding proteins for enhanced antifungal activity)

    Santoso Pugoh, Komada Takuya, Ishimine Yugo, Taniguchi Hiromasa, Minamihata Kosuke, Goto Masahiro, Taira Toki, Kamiya Noriho

    Journal of Bioscience and Bioengineering   134 ( 3 )   259 - 263   2022.9   ISSN:1389-1723

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    市販のアンフォテリシンB(AMB)製剤と表面電荷が異なるリポソームを組合せてハイブリッドリポソーム製剤を調製し、抗真菌活性の重要な要因を探索した。AMB含有リポソーム製剤(AMB-LF)の粒子サイズ分布とゼータ電位を含む特性評価では、陰イオン性と中性のAMB-LFはAMBを安定的にカプセル化できた。アニオン性または中性AMB-LFと未修飾LysMの組合せではAMBのMICが低下した。中性AMB-LFとPteris ryukyuensisキチナーゼ由来の人工パルミトイル化キチン結合ドメインの組合せではMICは更に減少し、中性AMB-LF単独と比較して最大15倍になった。以上より、脂質修飾性蛋白質結合剤と組合せたAMBの脂質基盤リポソーム製剤の真菌感染に対する有用であると考えられた。

  • Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

    Shihab Uddin, Md Rafiqul Islam, Rahman Md Moshikur, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    ACS Applied Bio Materials   5 ( 6 )   2586 - 2597   2022.6   ISSN:2576-6422 eISSN:2576-6422

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    Transdermal drug delivery systems (TDDSs) may be useful for preventing various diseases including cancer. However, the stratum corneum (SC) inhibits the permeation of foreign particles into the skin. To obtain an effective TDDS, we developed a protein-containing nanocarrier (PCNC) comprising an antigenic protein (ovalbumin/OVA) stabilized by a combination of surfactants, i.e., a lipid-based surface-active ionic liquid and Tween-80. The PCNC was lyophilized to remove water and cyclohexane and then dispersed in isopropyl myristate. It is biocompatible both in vitro and in vivo, and is suitable for use in a therapeutic TDDS. The skin permeability of the PCNC was significantly (p < 0.0001) enhanced, and the transdermal distribution and transdermal flux of the OVA delivery system were 25 and 28 times greater, respectively, than those of its aqueous formulation. The PCNC disrupted the order of lipid orientation in the skin's SC and increased intercellular protein delivery. It demonstrated effective antitumor activity, drastically (p < 0.001) suppressed tumor growth, increased mouse survival rates, and significantly (p < 0.001) stimulated the OVA-specific tumor immune response. The PCNC also increased the number of cytotoxic T cells expressing CD8 antibodies on their surfaces (CD8 + T-cells) in the tumor microenvironment. These findings suggest that PCNCs may be promising biocompatible carriers for transdermal antigenic protein delivery in tumor immunotherapy.

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  • Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B. International journal

    Pugoh Santoso, Kosuke Minamihata, Yugo Ishimine, Hiromasa Taniguchi, Takuya Komada, Ryo Sato, Masahiro Goto, Tomoya Takashima, Toki Taira, Noriho Kamiya

    ACS infectious diseases   8 ( 5 )   1051 - 1061   2022.5   ISSN:2373-8227

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    Combinations of antifungal drugs can have synergistic antifungal activity, achieving high therapeutic efficacy while minimizing the side effects. Amphotericin B (AMB) has been used as a standard antifungal drug for fungal infections; however, because of its high toxicity, new strategies to minimize the required dose are desirable. Chitinases have recently received attention as alternative safe antifungal agents. Herein, we report the combination of palmitoylated chitinase domains with AMB to enhance the antifungal activity. The chitin-binding domain (LysM) from Pteris ryukyuensis chitinase was site-specifically palmitoylated by conjugation reaction catalyzed by microbial transglutaminase. The palmitoylated LysM (LysM-Pal) exhibited strong antifungal activity against Trichoderma viride, inhibiting the growth completely at a concentration of 2 μM. This antifungal effect of LysM-Pal was mainly due to the effect of anchoring of palmitic acid motif to the plasma membrane of fungi. A combination of AMB with LysM-Pal resulted in synergistic enhancement of the antifungal activity. Intriguingly, LysM-Pal exhibited higher level of antifungal activity enhancement than palmitoylated catalytic domain (CatD) and fusion of LysM and CatD. Addition of 0.5 μM LysM-Pal to AMB reduced the minimal inhibition concentration of AMB to 0.31 μM (2.5 μM without LysM-Pal). The possible mechanism of the synergistic effect of AMB and LysM-Pal is destabilization of the plasma membrane by anchoring of palmitic acid and ergosterol extraction by AMB and destabilization of the chitin layer by LysM binding. The combination of LysM-Pal with AMB can drastically reduce the dose of AMB and may be a useful strategy to treat fungal infections.

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  • Amino Acid Ester based Phenolic Ionic Liquids as a Potential Solvent for the Bioactive Compound Luteolin: Synthesis, Characterization, and Food Preservation Activity

    Shimul, IM; Moshikur, RM; Minamihata, K; Moniruzzaman, M; Kamiya, N; Goto, M

    JOURNAL OF MOLECULAR LIQUIDS   349   2022.3   ISSN:0167-7322 eISSN:1873-3166

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    Ionic liquids (ILs) have gained great attention as potent solubilizing agents of poorly soluble bioactive compounds. The use of Luteolin (LUT) – a natural bioactive compound – is limited because of its poor aqueous solubility. To address this issue, this study reports potential ILs for effectively solubilizing LUT at ambient temperature. First, promising ILs were screened from a potential 180 ILs that were proposed by the combination of 20 standard amino acid ethyl esters cations and nine phenolic acids anions using the conductor-like screening model for real solvents (COSMO-RS); the activity coefficients of LUT at infinite dilution in ILs were used as the screening criteria. Four proline ethyl ester phenolate ILs (PEEP-ILs) composed of a biocompatible proline ethyl ester and bioactive phenolic acids (trans-ferulic, vanillic, p-coumaric, and 4-hydroxybenzoic acid) were selected and synthesized. The synthesized PEEP-ILs were characterized through 1H NMR, FT-IR, elemental analysis, TGA, and DSC. The experimental solubility of LUT in PEEP-ILs (60% IL in water) showed excellent solubility. Among the PEEP-ILs, proline ethyl ester ferulate (IL[ProEt][Fer]) exhibited the best LUT solubility, followed by ILs with p-coumarate (IL[ProEt][Cou]), vanillate (IL[ProEt][Van]), and 4-hydroxybenzoate (IL[ProEt][Ben]). 1H NMR assessment and COSMO-RS prediction confirmed that the ILs facilitated the solubilization of LUT through multiple hydrogen bonding, π − π, and cation − π interactions between the LUT and the ILs. The biocompatibility study revealed that PEEP-ILs were relatively harmless and low toxicity compared with conventional imidazolium, pyridinium, pyrrolidinium, piperidinium, and morpholinium-based ILs. The LUT dissolved in the newly-synthesized PEEP-ILs and demonstrated better organoleptic properties on red apple slices. These results indicate that PEEP-ILs can be potential green alternatives to conventional toxic solvents for dissolving poorly water-soluble bioactive natural preservatives.

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  • A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect Invited Reviewed International journal

    Yoshiro Tahara, Riko Mizuno, Tomoki Nishimura, Sada atsu Mukai, Rie Wakabayashi, Noriho Kamiya, Kazunari Akiyoshi, Masahiro Goto

    Biomaterials   282   121385 - 121385   2022.3   ISSN:0142-9612 eISSN:1878-5905

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  • Lyotropic liquid crystal-based transcutaneous peptide delivery system: Evaluation of skin permeability and potential for transcutaneous vaccination Invited Reviewed International journal

    #S. Kozaka, @R. Wakabayashi, @N. Kamiya, @M. Goto

    Acta Biomaterialia   138   273 - 284   2022.1   ISSN:1742-7061 eISSN:1878-7568

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    Transcutaneous drug delivery is a promising method in terms of drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, a number of techniques, such as microemulsion, solid-in-oil dispersions and liposomes, have been studied extensively. However, the low viscosity of these formulations limits drug retention on the skin and reduces patient acceptability. Although viscosity can be increased by adding a thickening reagent, such an addition often alters formulation nanostructures and drug solubility, and importantly, decreases skin permeability. In this study, a gel-like lyotropic liquid crystal (LLC) was used as a tool to enhance skin permeability. In particular, we prepared 1-monolinolein (ML)-based LLCs with different water contents. All LLCs significantly enhanced skin permeation of a peptide drug, an epitope peptide of melanoma, despite their high viscoelasticity. Fourier transform infra-red spectroscopic analysis of the skin surface treated with the LLCs revealed that the gyroid geometry more strongly interacted with the lamellar structure inside the stratum corneum (SC) than the diamond geometry. Finally, as the result of the in vivo tumor challenge experiment using B16F10 melanoma-bearing mice, the LLC with the gyroid geometry showed stronger vaccine effect against tumor than a subcutaneous injection. Collectively, ML-based LLCs, especially with the gyroid geometry, are a promising strategy to deliver biomacromolecules into skin. Statement of significance: Transcutaneous drug delivery is a promising method for drug repositioning and reformulation because of its non-invasive and easy-to-use features. To overcome the skin barrier, which is the biggest challenge in transcutaneous drug delivery, we used a gel-like lyotropic liquid crystal (LLC) as a novel tool to enhance skin permeability. In this paper, we demonstrated that an LLC with a specific liquid crystalline structure has the highest skin permeation enhancement effect for a peptide antigen as a model drug. Moreover, the peptide antigen-loaded LLC showed a vaccine effect that was comparable to a subcutaneous injection in vivo. This study provides a basis for designing a transcutaneous delivery system of peptide drugs with LLC.

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  • Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles Invited Reviewed International journal

    Rie Wakabayashi, Rino Imatani, Mutsuhiro Katsuya, Yuji Higuchi, Hiroshi Noguchi, Noriho Kamiya, Masahiro Goto

    Chemical Communications   58 ( 4 )   585 - 588   2022.1   ISSN:1359-7345 eISSN:1364-548X

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    Self-sorting and co-assembly of aqueous supramolecular fibres were formed using peptide amphiphiles having immiscible hydrophobic tails.

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  • alpha-L-Arabinofuranosidase as an Orthogonal Enzyme for Human Cells

    Ryosuke Kaneko, Tsuyoshi Oda, Ryosuke Yoshida, Chuya Tateishi, Kenta Tanito, Teruki Nii, Akihiro Kishimura, Noriho Kamiya, Takeshi Mori, Yoshiki Katayama

    CHEMISTRY LETTERS   50 ( 8 )   1493 - 1495   2021.8

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  • Production of an active Mus musculus IL-3 using updated silkworm-based baculovirus expression vector system

    Ryo Nagai, Takeru Ebihara, Kohei Kakino, Akitsu Masuda, Jian Xu, Kosuke Minamihata, Noriho Kamiya, Tatphon Kongkrongtong, Masahiro Kawahara, Hiroaki Mon, Tsuguru Fujii, Takahiro Kusakabe, Jae Man Lee

    Journal of Asia-Pacific Entomology   24 ( 3 )   544 - 549   2021.8

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  • Active human and murine tumor necrosis factor α cytokines produced from silkworm baculovirus expression system

    12 ( 6 )   2021.6

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    The tumor necrosis factor α (TNFα) has been employed as a promising reagent in treating autoimmunity and cancer diseases. To meet the substantial requirement of TNFα proteins, we report in this study that mature types of recombinant human and murine TNFα proteins are successfully expressed in the baculovirus expression system using silkworm larvae as hosts. The biological activities of purified products were verified in culture murine L929 cells, showing better performance over a commercial Escherichia coli-derived murine TNFα. By comparing the activity of purified TNFα with or without the tag removal, it is also concluded that the overall activity of purified TNFα cytokines could be further improved by the complete removal of C-terminal fusion tags. Collectively, our current attempt demonstrates an alternative platform for supplying high-quality TNFα products with excellent activities for further pharmaceutical and clinical trials.

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  • pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures Reviewed International journal

    R. Wakabayashi, A. Higuchi, H. Obayashi, M. Goto, N. Kamiya

    Int. J. Mol. Sci.   22 ( 7 )   2021.4

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    DOI: 10.3390/ijms22073459

  • Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

    Y. Kato, S. Yamada, K. Nishiyama, A. Satsuka, S. Re, D. Tomokiyo, J.-M. Lee, T. Tanaka, A. Nishimura, K. Yonemitsu, H. Asakura, Y. Ibuki, Y. Imai, N. Kamiya, K. Mizuguchi, T. Kusakabe, Y. Kanda*, M. Nishida*

    bioRxiv preprint   2021.3

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    DOI: https://doi.org/10.1101/2021.03.13.435221

  • Strategies for Making Multimeric and Polymeric Bifunctional Protein Conjugates and Their Applications as Bioanalytical Tools Invited Reviewed International journal

    #Dani PERMANA, @Kosuke MINAMIHATA, @Masahiro GOTO, @Noriho KAMIYA

    Anal. Sci.   37 ( 3 )   425 - 437   2021.3

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    DOI: https://doi.org/10.2116/analsci.20SCR07

  • Protein-Functionalized Gold Nanoparticles for Antibody Detection Using the Darkfield Microscopic Observation of Nanoparticle Aggregation

    Ken YOSHIMURA, PATMAWATI, Mizuo MAEDA, Noriho KAMIYA, Tamotsu ZAKO

    Analytical Sciences   37 ( 3 )   507 - 511   2021.3

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    DOI: 10.2116/analsci.20scp12

  • pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures. International journal

    Rie Wakabayashi, Ayato Higuchi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya

    International journal of molecular sciences   22 ( 7 )   2021.3

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    DOI: 10.3390/ijms22073459

  • Extending the Half-Life of a Protein in Vivo by Enzymatic Labeling with Amphiphilic Lipopeptides

    Mari Takahara, Shinichi Mochizuki, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Kazuo Sakurai, Noriho Kamiya

    Bioconjugate Chemistry   2021.3

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    DOI: 10.1021/acs.bioconjchem.1c00027

  • Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation. International journal

    Yuya Hirakawa, Hiroshi Ueda, Yusuke Takata, Kosuke Minamihata, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences   158   105667 - 105667   2021.3

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    DOI: 10.1016/j.ejps.2020.105667

  • Recombinant production of active microbial transglutaminase in E. coli by using self-cleavable zymogen with mutated propeptide. International journal

    Ryo Sato, Kosuke Minamihata, Ryutaro Ariyoshi, Hiromasa Taniguchi, Noriho Kamiya

    Protein expression and purification   176   105730 - 105730   2020.12

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    DOI: 10.1016/j.pep.2020.105730

  • Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation. International journal

    Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical communications (Cambridge, England)   56 ( 89 )   13756 - 13759   2020.11

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    DOI: 10.1039/d0cc04491a

  • Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect. International journal

    Yoshiro Tahara, Kaho Morita, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 10 )   3845 - 3856   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.0c00598

  • PolyTag: A peptide tag that affords scaffold-less covalent protein assembly catalyzed by microbial transglutaminase. Reviewed International journal

    R Sato, K Minamihata, R Wakabayashi, M Goto, N Kamiya

    Analytical biochemistry   600   113700 - 113700   2020.7

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    DOI: 10.1016/j.ab.2020.113700

  • Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids. Reviewed

    Wahyu Ramadhan, Yuki Ohama, Kosuke Minamihata, Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Journal of bioscience and bioengineering   130 ( 4 )   416 - 423   2020.7

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    DOI: 10.1016/j.jbiosc.2020.05.010

  • Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir Reviewed

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   582   2020.5

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    DOI: 10.1016/j.ijpharm.2020.119335

  • Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir

    Md. Rafiqul Islam, Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   582   119335 - 119335   2020.5

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    DOI: 10.1016/j.ijpharm.2020.119335

  • Ionic liquid-in-oil microemulsions prepared with biocompatible choline carboxylic acids for improving the transdermal delivery of a sparingly soluble drug Reviewed

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Pharmaceutics   12 ( 4 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/pharmaceutics12040392

  • Poly(ethylene glycol)-based biofunctional hydrogels mediated by peroxidase-catalyzed cross-linking reactions Reviewed

    Rie Wakabayashi, Wahyu Ramadhan, Kousuke Moriyama, Masahiro Goto, Noriho Kamiya

    Polymer Journal   in press   2020.4

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  • Optimal silkworm larva host for high-level production of Mus musculus IL-4 using a baculovirus expression vector system Reviewed

    Masahiko Kobayashi, Jian Xu, Kohei Kakino, Akitsu Masuda, Masato Hino, Naoki Fujimoto, Kosuke Minamihata, Noriho Kamiya, Hiroaki Mon, Hiroshi Iida, Masateru Takahashi, Takahiro Kusakabe, Jae Man Lee

    Journal of Asia-Pacific Entomology   23 ( 1 )   268 - 273   2020.4

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    DOI: 10.1016/j.aspen.2019.12.014

  • Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug. International journal

    Md Rafiqul Islam, Md Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Pharmaceutics   12 ( 4 )   2020.4

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    DOI: 10.3390/pharmaceutics12040392

  • Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel. Reviewed International journal

    Wahyu Ramadhan, Genki Kagawa, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Scientific reports   10 ( 1 )   6710 - 6710   2020.4

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    DOI: 10.1038/s41598-020-63362-4

  • Optimal silkworm larva host for high-level production of Mus musculus IL-4 using a baculovirus expression vector system Reviewed

    Masahiko Kobayashi, Jian Xu, Kohei Kakino, Akitsu Masuda, Masato Hino, Naoki Fujimoto, Kosuke Minamihata, Noriho Kamiya, Hiroaki Mon, Hiroshi Iida, Masateru Takahashi, Takahiro Kusakabe, Jae Man Lee

    Journal of Asia-Pacific Entomology   23 ( 1 )   268 - 273   2020.4

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    DOI: 10.1016/j.aspen.2019.12.014

  • A novel binary supercooled liquid formulation for transdermal drug delivery Reviewed

    Yuya Hirakawa, Hiroshi Ueda, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    Biological and Pharmaceutical Bulletin   43 ( 3 )   393 - 398   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpb.b19-00642

  • Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis. International journal

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   12 ( 3 )   2020.3

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    DOI: 10.3390/pharmaceutics12030240

  • Linear Polymerization of Protein by Sterically Controlled Enzymatic Cross-Linking with a Tyrosine-Containing Peptide Loop. Reviewed International journal

    Dani Permana, Kosuke Minamihata, Ryo Sato, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    ACS omega   5 ( 10 )   5160 - 5169   2020.3

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    DOI: 10.1021/acsomega.9b04163

  • Solid-in-oil nanodispersions for transcutaneous immunotherapy of Japanese cedar pollinosis Reviewed

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   12 ( 3 )   2020.3

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    DOI: 10.3390/pharmaceutics12030240

  • A solid-in-oil nanodispersion system for transcutaneous immunotherapy of cow’s milk allergies Reviewed

    12 ( 3 )   2020.3

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    An allergy to cow’s milk proteins is the most common food allergy in infants and toddlers. Conventional oral immunotherapy for cow’s milk allergies requires hospital admission due to the risk of severe allergic reactions, including anaphylaxis. Therefore, a simpler and safer immunotherapeutic method is desirable. We examined transcutaneous immunotherapy with a solid-in-oil (S/O) system. In the S/O system, nano-sized particles of proteins are dispersed in an oil-vehicle with the assistance of nonionic surfactants. In the present study, the S/O system enhanced the skin permeation of the allergen molecule β-lactoglobulin (BLG), as compared with a control PBS solution. The patches containing BLG in the S/O nanodispersion skewed the immune response in the allergy model mice toward T helper type 1 immunity, indicating the amelioration of allergic symptoms. This effect was more pronounced when the immunomodulator resiquimod (R-848) was included in the S/O system.

    DOI: 10.3390/pharmaceutics12030205

  • Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery Synthesis, characterization, and skin-penetration evaluation Reviewed

    Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Journal of Molecular Liquids   299   2020.2

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    DOI: 10.1016/j.molliq.2019.112166

  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier. International journal

    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 2 )   645 - 655   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.9b01104

  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier Reviewed

    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Takahiro Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto

    Molecular pharmaceutics   17 ( 2 )   645 - 655   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.9b01104

  • Solid-in-oil nanodispersions for intranasal vaccination Enhancement of mucosal and systemic immune responses Reviewed

    Qingliang Kong, Momoko Kitaoka, Yoshiro Tahara, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   572   2019.12

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    DOI: 10.1016/j.ijpharm.2019.118777

  • Synthetic Strategies for Artificial Lipidation of Functional Proteins Invited Reviewed

    Mari Takahara, Noriho Kamiya

    Chemistry-A European Journal   Accepted   2019.12

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    Synthetic Strategies for Artificial Lipidation of Functional Proteins

    DOI: 10.1002/chem.201904568

  • Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses. Reviewed

    Kong Q, Kitaoka M, Tahara Y, Wakabayashi R, Kamiya N, Goto M

    International journal of pharmaceutics   572   118777   2019.12

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    Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses.

    DOI: 10.1016/j.ijpharm.2019.118777

  • A novel binary supercooled liquid formulation for transdermal drug delivery. Reviewed

    Hirakawa Y, Ueda H, Wakabayashi R, Kamiya N, Goto M

    Biological & pharmaceutical bulletin   2019.12

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    A novel binary supercooled liquid formulation for transdermal drug delivery.

    DOI: 10.1248/bpb.b19-00642

  • Transcutaneous delivery of immunomodulating pollen extract-galactomannan conjugate by solid-in-oil nanodispersions for pollinosis immunotherapy Reviewed

    Qingliang Kong, Kouki Higasijima, Rie Wakabayashi, Yoshiro Tahara, Momoko Kitaoka, Hiroki Obayashi, Yanting Hou, Noriho Kamiya, Masahiro Goto

    Pharmaceutics   11 ( 11 )   2019.11

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    DOI: 10.3390/pharmaceutics11110563

  • New insight into transdermal drug delivery with supersaturated formulation based on co-amorphous system Reviewed

    Yuya Hirakawa, Hiroshi Ueda, Tetsuya Miyano, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   569   2019.10

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    DOI: 10.1016/j.ijpharm.2019.118582

  • Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy. Reviewed

    Kong Q, Higasijima K, Wakabayashi R, Tahara Y, Kitaoka M, Obayashi H, Hou Y, Kamiya N, Goto M

    Pharmaceutics   11 ( 11 )   2019.10

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    Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy.

    DOI: 10.3390/pharmaceutics11110563

  • Synthesis and characterization of choline–fatty-acid-based ionic liquids A new biocompatible surfactant Reviewed

    551   72 - 80   2019.9

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    Ionic liquid (IL)surfactants have attracted great interest as promising substitutes for conventional surfactants owing to their exceptional and favorable physico-chemical properties. However, most IL surfactants are not eco-friendly and form unstable micelles, even when using a high concentration of the surfactant. In this study, we prepared a series of halogen-free and biocompatible choline–fatty-acid-based ILs with different chain lengths and degrees of saturation, and we then investigated their micellar properties in aqueous solutions. Characterization of the synthesized surface-active ILs (SAILs)was performed by 1 H and 13 C nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and elemental analysis. The surface-active properties of the SAILs were investigated by tensiometry, conductometry, and dynamic light scattering measurements. The critical micelle concentration of the SAILs was found to be 2–4 times lower than those of conventional surfactants. The thermodynamic properties of micellization (ΔG 0 m , ΔH 0 m , and ΔS 0 m )indicate that the micellization process of the SAILs is spontaneous, stable, and entropy-driven at room temperature. The cytotoxicity of the SAILs was evaluated using mammalian cell line NIH 3T3. Importantly, [Cho][Ole]shows lower toxicity than the analogous ILs with conventional surfactants. These results clearly suggest that these environmentally friendly SAILs can be used as a potential alternative to conventional ILs for various purposes, including biological applications.

    DOI: 10.1016/j.jcis.2019.04.095

  • A nano-sized gel-in-oil suspension for transcutaneous protein delivery Reviewed

    Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

    International Journal of Pharmaceutics   567   2019.8

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    DOI: 10.1016/j.ijpharm.2019.118495

  • A nano-sized gel-in-oil suspension for transcutaneous protein delivery Reviewed International journal

    Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

    567   118495 - 118495   2019.8

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    A nano-sized gel-in-oil suspension for transcutaneous protein delivery
    We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.

    DOI: 10.1016/j.ijpharm.2019.118495

  • Expression and purification of biologically active human granulocyte-macrophage colony stimulating factor (hGM-CSF) using silkworm-baculovirus expression vector system Reviewed

    Yurie Kinoshita, Jian Xu, Akitsu Masuda, Kosuke Minamihata, Noriho Kamiya, Hiroaki Mon, Ryosuke Fujita, Takahiro Kusakabe, Man Lee

    Protein Expression and Purification   159   69 - 74   2019.7

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    DOI: 10.1016/j.pep.2019.03.010

  • Expression and purification of biologically active human granulocyte-macrophage colony stimulating factor (hGM-CSF) using silkworm-baculovirus expression vector system. Reviewed

    Kinoshita Y, Xu J, Masuda A, Minamihata K, Kamiya N, Mon H, Fujita R, Kusakabe T, Lee JM

    Protein expression and purification   159   69 - 74   2019.7

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    Expression and purification of biologically active human granulocyte-macrophage colony stimulating factor (hGM-CSF) using silkworm-baculovirus expression vector system.

    DOI: 10.1016/j.pep.2019.03.010

  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations Reviewed

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   565   219 - 226   2019.6

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    DOI: 10.1016/j.ijpharm.2019.05.020

  • Polymerization of Horseradish Peroxidase by a Laccase-Catalyzed Tyrosine Coupling Reaction. Reviewed International journal

    Permana D, Minamihata K, Tatsuke T, Lee JM, Kusakabe T, Goto M, Kamiya N

    Biotechnology journal   14 ( 6 )   e1800531   2019.6

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    Polymerization of Horseradish Peroxidase by a Laccase-Catalyzed Tyrosine Coupling Reaction.
    The polymerization of proteins can create newly active and large bio-macromolecular assemblies that exhibit unique functionalities depending on the properties of the building block proteins and the protein units in polymers. Herein, the first enzymatic polymerization of horseradish peroxidase (HRP) is reported. Recombinant HRPs fused with a tyrosine-tag (Y-tag) through a flexible linker at the N- and/or C-termini are expressed in silkworm, Bombyx mori. Trametes sp. laccase (TL) is used to activate the tyrosine of Y-tagged HRPs with molecular O2 to form a tyrosyl-free radical, which initiates the tyrosine coupling reaction between the HRP units. A covalent dityrosine linkage is also formed through a HRP-catalyzed self-crosslinking reaction in the presence of H2 O2 . The addition of H2 O2 in the self-polymerization of Y-tagged HRPs results in lower activity of the HRP polymers, whereas TL provides site-selectivity, mild reaction conditions and maintains the activity of the polymeric products. The cocrosslinking of Y-tagged HRPs and HRP-protein G (Y-HRP-pG) units catalyzed by TL shows a higher signal in enzyme-linked immunosorbent assay (ELISA) than the genetically pG-fused HRP, Y-HRP-pG, and its polymers. This new enzymatic polymerization of HRP promises to provide highly active and functionalized polymers for biomedical applications and diagnostics probes.

    DOI: 10.1002/biot.201800531

  • Enzymatically Prepared Dual Functionalized Hydrogels with Gelatin and Heparin to Facilitate Cellular Attachment and Proliferation Reviewed

    Wahyu Ramadhan, Genki Kagawa, Yusei Hamada, Kousuke Moriyama, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   2 ( 6 )   2600 - 2609   2019.6

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    DOI: 10.1021/acsabm.9b00275

  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity Reviewed

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   55   7737 - 7740   2019.6

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    Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

  • Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery Reviewed

    Wakabayashi Rie, Obayashi Hiroki, Hashimoto Ryuichiro, Kamiya Noriho, Goto Masahiro

    CHEMICAL COMMUNICATIONS   55 ( 49 )   6997 - 7000   2019.6

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    Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery

    DOI: 10.1039/c9cc02473e

  • Functional horseradish peroxidase−streptavidin chimeric proteins prepared using a silkworm-baculovirus expression system for diagnostic purposes Reviewed

    297   28 - 31   2019.5

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    Rapid, convenient, sensitive detection methods are of the utmost importance in analytical tools. Enzyme-based signal amplification using horseradish peroxidase (HRP) is commonly implemented in clinical diagnostics kits based on enzyme-linked immunosorbent assay (ELISA), by which the limit of detection is greatly improved. Herein we report the design and preparation of recombinant fusion proteins comprising HRP and streptavidin (Stav), in which HRP was fused to either the N- or C-terminus of Stav ((HRP)
    4
    –Stav or Stav–(HRP)
    4
    , respectively) using a baculovirus-silkworm expression system. Both (HRP)
    4
    –Stav and Stav–(HRP)
    4
    were secreted in the apo form but they were easily converted to the holo form and activated by simple incubation with hemin overnight at 4 °C. The activated (HRP)
    4
    –Stav and Stav–(HRP)
    4
    could be combined with a commercial biotinylated anti-OVA IgG antibody to detect ovalbumin (OVA) as the antigen in ELISA. The enzymatic activity of (HRP)
    4
    –Stav was twofold higher than that of Stav–(HRP)
    4
    , and the sensitivity of (HRP)
    4
    -Stav in ELISA was higher than that of a commercial HRP–Stav chemical conjugate. The successful use of (HRP)
    4
    –Stav chimeric protein as a molecular probe in ELISA shows that the baculovirus-silkworm expression system is promising to produce enzyme–Stav conjugates to substitute for those prepared by chemical methods.

    DOI: 10.1016/j.jbiotec.2019.03.007

  • Synthesis and characterization of choline–fatty-acid-based ionic liquids: A new biocompatible surfactant Reviewed

    551 ( 1 )   72 - 80   2019.5

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  • Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion Reviewed International journal

    Djohan Yovita, Azukizawa Tomoki, Patmawati, Sakai Kotaro, Yano Yuki, Sato Fumiya, Takahashi Ryoji, Yohda Masafumi, Maeda Mizuo, Kamiya Noriho, Zako Tamotsu

    BIOMATERIALS SCIENCE   7 ( 5 )   1801 - 1804   2019.5

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    Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion
    Here we report a novel aspect of molecular chaperone prefoldin (PFD) as a biomaterial in the biocatalytic synthesis of gold nanoparticles (AuNPs) using glycerol dehydrogenase (GLD). We found that PFD could inhibit the aggregation of AuNPs during the biosynthesis, leading to the formation of AuNPs with controlled size distribution.

    DOI: 10.1039/c8bm01026a

  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations Reviewed

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    International Journal of Pharmaceutics   565   219 - 226   2019.5

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    In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations

  • Functional horseradish peroxidase-streptavidin chimeric proteins prepared using a silkworm-baculovirus expression system for diagnostic purposes. Reviewed

    Patmawati, Minamihata K, Tatsuke T, Lee JM, Kusakabe T, Kamiya N

    Journal of biotechnology   297   28 - 31   2019.5

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    Functional horseradish peroxidase-streptavidin chimeric proteins prepared using a silkworm-baculovirus expression system for diagnostic purposes.

    DOI: 10.1016/j.jbiotec.2019.03.007

  • Enzymatic Cell-Surface Decoration with Proteins using Amphiphilic Lipid-Fused Peptide Substrates Reviewed International journal

    Mari Takahara, Rie Wakabayashi, Naoki Fujimoto, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   25 ( 30 )   7315 - 7321   2019.5

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    DOI: 10.1002/chem.201900370

  • Preparation and characterization of semi-refined carrageenan from Kappaphycus alvarezii seaweed bleached by Peracetic Acid Reviewed

    Uju, E. Prasetyaningsih, J. Santoso, N. Kamiya, T. Oshima

    3rd EMBRIO International Workshop on Marine Biodiversity: Understanding, Utilization, Conservation, EIW 2018 IOP Conference Series: Earth and Environmental Science   278 ( 1 )   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1755-1315/278/1/012077

  • Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion Reviewed

    Yovita Djohan, Tomoki Azukizawa, Patmawati, Kotaro Sakai, Yuki Yano, Fumiya Sato, Ryoji Takahashi, Masafumi Yohda, Mizuo Maeda, Noriho Kamiya, Tamotsu Zako

    Biomaterials Science   7 ( 5 )   1801 - 1804   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8bm01026a

  • Transcutaneous Codelivery of Tumor Antigen and Resiquimod in Solid-in-Oil Nanodispersions Promotes Antitumor Immunity Reviewed

    Rie Wakabayashi, Hidetoshi Kono, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    ACS Biomaterials Science & Engineering   5 ( 5 )   2297 - 2306   2019.4

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    Transcutaneous Codelivery of Tumor Antigen and Resiquimod in Solid-in-Oil Nanodispersions Promotes Antitumor Immunity

  • 昆虫工場を利用したウイルス様粒子ワクチン生産系の確立とその応用

    増田 亮津, 宮田 健, 南畑 孝介, 神谷 典穂, 李 在萬, 日下部 宜宏

    衛生動物   70 ( Suppl. )   68 - 68   2019.3

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    Language:Japanese  

  • Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery Reviewed

    Razi Muhamad Alif, Wakabayashi Rie, Goto Masahiro, Kamiya Noriho

    LANGMUIR   35 ( 7 )   2610 - 2618   2019.2

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    Self-Assembled Reduced Albumin and Glycol Chitosan Nanoparticles for Paclitaxel Delivery

    DOI: 10.1021/acs.langmuir.8b02809

  • Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor Reviewed

    Shuto Kozaka, Rie Wakabayashi, Onofrio Annunziata, Milan Balaz, Masahiro Goto, Noriho Kamiya, Sergei V. Dzyuba

    Journal of Photochemistry and Photobiology A: Chemistry   369   115 - 118   2019.1

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    DOI: 10.1016/j.jphotochem.2018.10.006

  • Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique Reviewed

    Hardiningtyas Safrina Dyah, Wakabayashi Rie, Ishiyama Ryutaro, Owada Yuki, Goto Masahiro, Kamiya Noriho

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   138 - 143   2019.1

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    Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

    DOI: 10.1252/jcej.18we060

  • Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor Reviewed

    Kozaka Shuto, Wakabayashi Rie, Annunziata Onofrio, Balaz Milan, Goto Masahiro, Kamiya Noriho, Dzyuba Sergei V

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY   369   115 - 118   2019.1

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    Effect of macromolecular crowding on the conformational behaviour of a porphyrin rotor

    DOI: 10.1016/j.jphotochem.2018.10.006

  • Transcutaneous codelivery of tumor antigen and resiquimod in solid-in-oil nanodispersions promotes antitumor immunity Reviewed

    Rie Wakabayashi, Hidetoshi Kono, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    ACS Biomaterials Science and Engineering   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsbiomaterials.9b00260

  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity Reviewed

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Chemical Communications   55 ( 54 )   7737 - 7740   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc02812a

  • Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery Reviewed

    Rie Wakabayashi, Hiroki Obayashi, Ryuichiro Hashimoto, Noriho Kamiya, Masahiro Goto

    Chemical Communications   55 ( 49 )   6997 - 7000   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc02473e

  • Polymerization of Horseradish Peroxidase by a Laccase-Catalyzed Tyrosine Coupling Reaction Reviewed

    Dani Permana, Kosuke Minamihata, Tsuneyuki Tatsuke, Jae M. Lee, Takahiro Kusakabe, Masahiro Goto, Noriho Kamiya

    Biotechnology Journal   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201800531

  • Enhanced potential of therapeutic applications of curcumin using solid-in-water nanodispersion technique Reviewed

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Ryutaro Ishiyama, Yuki Owada, Masahiro Goto, Noriho Kamiya

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   52 ( 1 )   138 - 143   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1252/jcej.18we060

  • Design of Lipid-Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase Reviewed

    Mari Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    ACS Applied Bio Materials   1 ( 6 )   1823 - 1829   2018.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsabm.8b00271

  • Liquid Marbles as an Easy-to-Handle Compartment for Cell-Free Synthesis and In Situ Immobilization of Recombinant Proteins. International journal

    Noriho Kamiya, Yuki Ohama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto

    Biotechnology journal   13 ( 12 )   e1800085   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201800085

  • Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control Reviewed

    Wakabayashi Rie, Suehiro Ayumi, Goto Masahiro, Kamiya Noriho

    Chemical Communications, accepted.   2018.12

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    Designer aromatic peptide amphiphiles for self-assembly and enzymatic display of proteins with morphology control

  • Laccase-catalyzed bioconjugation of tyrosine-tagged functional proteins Reviewed

    Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   126 ( 5 )   559 - 566   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbiosc.2018.05.013

  • Laccase-catalyzed bioconjugation of tyrosine-tagged functional proteins. Reviewed

    Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Journal of bioscience and bioengineering   126 ( 5 )   559 - 566   2018.11

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    DOI: 10.1016/j.jbiosc.2018.05.013

  • Design of lipid-protein conjugate with a self-assembling ability on a cell membrane by using microbial transglutaminase reaction Reviewed

    Takahara Mari, Wakabayashi Rie, Minamihata Kosuke, Goto Masahiro, Kamiya Noriho

    ACS Appl. Bio Mater., accepted. DOI: 10.1021/acsabm.8b00271.   2018.8

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    Design of lipid-protein conjugate with a self-assembling ability on a cell membrane by using microbial transglutaminase reaction

  • Production of a biologically active human basic fibroblast growth factor using silkworm-baculovirus expression vector system Reviewed

    Akitsu Masuda, Jian Xu, Kosuke Minamihata, Genki Kagawa, Yusei Hamada, Yoshiki Morifuji, Takumi Yano, Masato Hino, Daisuke Morokuma, Noriko Karasaki, Hiroaki Mon, Noriho Kamiya, Takahiro Kusakabe, Jae Man Lee

    Journal of Asia-Pacific Entomology   21 ( 2 )   716 - 720   2018.6

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    DOI: 10.1016/j.aspen.2018.05.002

  • Production of a biologically active human basic fibroblast growth factor using silkworm-baculovirus expression vector system Reviewed

    Akitsu Masuda, Jian Xu, Kosuke Minamihata, Genki Kagawa, Yusei Hamada, Yoshiki Morifuji, Takumi Yano, Masato Hino, Daisuke Morokuma, Noriko Karasaki, Hiroaki Mon, Noriho Kamiya, Takahiro Kusakabe, Jae Man Lee

    Journal of Asia-Pacific Entomology   21 ( 2 )   716 - 720   2018.6

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    DOI: 10.1016/j.aspen.2018.05.002

  • Mechanistic investigation of transcutaneous protein delivery using solid-in-oil nanodispersion: A case study with phycocyanin. Reviewed International journal

    Safrina Dyah Hardiningtyas, Rie Wakabayashi, Momoko Kitaoka, Yoshiro Tahara, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   127   44 - 50   2018.6

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    DOI: 10.1016/j.ejpb.2018.01.020

  • Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment Reviewed

    Md. Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Molecular Pharmaceutics   15 ( 6 )   2484 - 2488   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.8b00305

  • Expression and Activation of Horseradish Peroxidase-Protein A/G Fusion Protein in Silkworm Larvae for Diagnostic Purposes. Reviewed International journal

    Patmawati Xxxx, Kosuke Minamihata, Tsuneyuki Tatsuke, Jae Man Lee, Takahiro Kusakabe, Noriho Kamiya

    Biotechnology journal   13 ( 6 )   e1700624   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201700624

  • Ionic-Liquid-Based Paclitaxel Preparation A New Potential Formulation for Cancer Treatment Reviewed

    Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

    Molecular pharmaceutics   15 ( 6 )   2484 - 2488   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.8b00305

  • Genipin-stabilized caseinatehitosan nanoparticles for enhanced stability and anti-cancer activity of curcumin Reviewed

    Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya

    Colloids and Surfaces B: Biointerfaces   164   308 - 315   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.colsurfb.2018.01.041

  • Casein-based scaffold for artificial cellulosome design Reviewed

    Geisa A.L.G. Budinova, Yutaro Mori, Tsutomu Tanaka, Noriho Kamiya

    Process Biochemistry   66   140 - 145   2018.3

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    DOI: 10.1016/j.procbio.2017.12.013

  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma Reviewed

    Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Molecular Pharmaceutics   15 ( 3 )   955 - 961   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.7b00894

  • Casein-based scaffold for artificial cellulosome design Reviewed

    Geisa A.L.G. Budinova, Yutaro Mori, Tsutomu Tanaka, Noriho Kamiya

    Process Biochemistry   66   140 - 145   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.procbio.2017.12.013

  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma Reviewed

    Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    Molecular Pharmaceutics   15 ( 3 )   955 - 961   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.molpharmaceut.7b00894

  • Formation and characterization of caseinate-chitosan nanocomplexes for encapsulation of Curcumin Reviewed

    Muhamad Alif Razi, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   51 ( 5 )   445 - 453   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1252/jcej.17we293

  • Design of Artificial Supramolecular Protein Assemblies by Enzymatic Bioconjugation for Biocatalytic Reactions

    Geisa A.L.G. Budinova, Yutaro Mori, Noriho Kamiya

    Emerging Areas in Bioengineering   93 - 103   2018.1

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    DOI: 10.1002/9783527803293.ch6

  • Modular surface display for porcine circovirus type 2 virus-like particles mediated by microbial transglutaminase Reviewed

    Akitsu Masuda, Kosuke Minamihata, Masato Hino, Daisuke Morokuma, Noriko Karasaki, Hiroaki Mon, Noriho Kamiya, Takahiro Kusakabe, Man Lee

    Journal of Insect Biotechnology and Sericology   87 ( 2 )   53 - 60   2018.1

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    DOI: 10.11416/jibs.87.2_053

  • Polymeric SpyCatcher Scaffold Enables Bioconjugation in a Ratio-Controllable Manner Reviewed

    Lili Jia, Kosuke Minamihata, Hirofumi Ichinose, Kouhei Tsumoto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   12 ( 12 )   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201700195

  • Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase Reviewed

    Mad Takahara, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   28 ( 12 )   2954 - 2961   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.bioconjchem.7b00594

  • Transcutaneous immunotherapy of pollinosis using solid-in-oil nanodispersions loaded with T cell epitope peptides Reviewed

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   529 ( 1-2 )   401 - 409   2017.8

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    DOI: 10.1016/j.ijpharm.2017.07.020

  • Transcutaneous immunotherapy of pollinosis using solid-in-oil nanodispersions loaded with T cell epitope peptides Reviewed

    Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   529 ( 1-2 )   401 - 409   2017.8

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    DOI: 10.1016/j.ijpharm.2017.07.020

  • Extraction and Stripping Behavior of Platinum Group Metals Using an Amic-Acid-Type Extractant

    Wataru Yoshida, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   50 ( 7 )   521 - 526   2017.7

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    DOI: 10.1252/jcej.16we335

  • Direct Ethanol Production from Ionic Liquid-Pretreated Lignocellulosic Biomass by Cellulase-Displaying Yeasts Reviewed

    Ryosuke Yamada, Kazunori Nakashima, Nanami Asai-Nakashima, Wataru Tokuhara, Nobuhiro Ishida, Satoshi Katahira, Noriho Kamiya, Chiaki Ogino, Akihiko Kondo

    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY   182 ( 1 )   229 - 237   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12010-016-2322-2

  • FRET-based detection of isozyme-specific activities of transglutaminases Reviewed International journal

    Tatsukawa, Hideki, Liu, Hong Hong, Oba, Shota, Noriho Kamiya, Nakanishi, Yoichi, Hitomi, Kiyotaka

    AMINO ACIDS   49 ( 3 )   615 - 623   2017.3

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    DOI: 10.1007/s00726-016-2322-0

  • Transcutaneous pollinosis immunotherapy using a solid-in-oil nanodispersion system carrying T cell epitope peptide and R848. Reviewed International journal

    Kitaoka M, Naritomi A, Kawabe Y, Kamihira M, Kamiya N, Goto M

    Bioengineering & translational medicine   2 ( 1 )   102 - 108   2017.3

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    Transcutaneous pollinosis immunotherapy using a solid-in-oil nanodispersion system carrying T cell epitope peptide and R848.
    Antigen-specific immunotherapy is the only curative approach for the treatment of allergic diseases such as Japanese cedar pollinosis. Immunotherapy using a T cell epitope vaccine in combination with the adjuvant R848 is of particular interest as a safe and effective approach to treat allergic diseases. Herein, we propose a simple and easy to handle vaccine administration method using the original solid-in-oil (S/O) nanodispersion system that permeates through the skin. The S/O nanodispersion system is composed of nanoparticles of hydrophilic molecules surrounded with hydrophobic surfactants that are dispersed in an oil vehicle. The system has potential to carry and deliver both hydrophilic and hydrophobic bioactives. Hydrophilic T cell epitope peptide was efficiently delivered through mouse skin using the S/O nanodispersion system and lowered antigen-specific IgE levels in pollinosis model mice. Addition of the hydrophobic adju1vant R848 significantly lowered the antibody secretion and shifted the Th1/Th2-balance toward Th1-type immunity in the model mice, showing the potential to alleviate Japanese cedar pollinosis.

    DOI: 10.1002/btm2.10048

  • FRET-based detection of isozyme-specific activities of transglutaminases. Reviewed International journal

    Hideki Tatsukawa, Hong Hong Liu, Shota Oba, Noriho Kamiya, Yoichi Nakanishi, Kiyotaka Hitomi

    Amino acids   49 ( 3 )   615 - 623   2017.3

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    DOI: 10.1007/s00726-016-2322-0

  • Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay Reviewed International journal

    Rie Wakabayashi, Yahiro, Kensuke, Hayashi, Kounosuke, Masahiro Goto, Noriho Kamiya

    BIOMACROMOLECULES   18 ( 2 )   422 - 430   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biomac.6b01538

  • Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay Reviewed

    Rie Wakabayashi, Kensuke Yahiro, Kounosuke Hayashi, Masahiro Goto, Noriho Kamiya

    BIOMACROMOLECULES   18 ( 2 )   422 - 430   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biomac.6b01538

  • Extraction and stripping behavior of platinum group metals using an amic-acid-type extractant Reviewed

    Wataru Yoshida, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   50 ( 7 )   521 - 526   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1252/jcej.16we335

  • Direct Ethanol Production from Ionic Liquid-Pretreated Lignocellulosic Biomass by Cellulase-Displaying Yeasts Reviewed

    Ryosuke Yamada, Kazunori Nakashima, Nanami Asai-Nakashima, Wataru Tokuhara, Nobuhiro Ishida, Satoshi Katahira, Noriho Kamiya, Chiaki Ogino, Akihiko Kondo

    Applied Biochemistry and Biotechnology   182 ( 1 )   229 - 237   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12010-016-2322-2

  • FRET-based detection of isozyme-specific activities of transglutaminases Reviewed

    Hideki Tatsukawa, Hong Hong Liu, Shota Oba, Noriho Kamiya, Yoichi Nakanishi, Kiyotaka Hitomi

    Amino Acids   49 ( 3 )   615 - 623   2017

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    DOI: 10.1007/s00726-016-2322-0

  • Solid-in-oil nanodispersions for transdermal drug delivery systems Reviewed International journal

    Kitaoka, Momoko, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1375 - 1385   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201600081

  • Solid-in-oil nanodispersions for transdermal drug delivery systems Reviewed

    Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1375 - 1385   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/biot.201600081

  • Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation Reviewed

    Kousuke Moriyama, Shono Naito, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   11 ( 11 )   1452 - 1460   2016.11

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    DOI: 10.1002/biot.201600087

  • Editorial Asian Congress of Biotechnology 2015 Reviewed

    Hyung Joon Cha, Noriho Kamiya, Vikineswary Sabaratnam

    Biotechnology Journal   11 ( 11 )   1371 - 1372   2016.11

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    DOI: 10.1002/biot.201600650

  • Synergistic degradation of arabinoxylan by free and immobilized xylanases and arabinofuranosidase Reviewed International journal

    Jia, Lili, Budinova, Geisa A. L. G., Takasugi, Yusaku, Noda, Shuhei, Tanaka, Tsutomu, Hirofumi Ichinose, Masahiro Goto, Kamiya, Noriho

    BIOCHEMICAL ENGINEERING JOURNAL   114   271 - 278   2016.10

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    DOI: 10.1016/j.bej.2016.07.013

  • Synergistic degradation of arabinoxylan by free and immobilized xylanases and arabinofuranosidase Reviewed

    Lili Jia, Geisa A. L. G. Budinova, Yusaku Takasugi, Shuhei Noda, Tsutomu Tanaka, Hirofumi Ichinose, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL ENGINEERING JOURNAL   114   271 - 278   2016.10

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    DOI: 10.1016/j.bej.2016.07.013

  • Salt-Switchable Artificial Cellulase Regulated by a DNA Aptamer Reviewed

    Mari Takahara, Geisa Aparecida Lopes Goncalves Budinova, Hikaru Nakazawa, Yutaro Mori, Mitsuo Umetsu, Noriho Kamiya

    BIOMACROMOLECULES   17 ( 10 )   3356 - 3362   2016.10

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    DOI: 10.1021/acs.biomac.6b01141

  • Diglycolic amic acid-modified E. coli as a biosorbent for the recovery of rare earth elements Reviewed International journal

    Hosomomi, Yukiho, F. Kubota, Rie Wakabayashi, Kamiya, Noriho, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   113   102 - 106   2016.9

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    DOI: 10.1016/j.bej.2016.06.005

  • Diglycolic amic acid-modified E. coli as a biosorbent for the recovery of rare earth elements

    Yukiho Hosomomi, Rie Wakabayashi, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Biochemical Engineering Journal   113   102 - 106   2016.9

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    Diglycolic amic acid-modified E. coli as a biosorbent for the recovery of rare earth elements
    © 2016 Elsevier B.V. Biosorption has recently attracted much attention as an alternative to conventional techniques for the recovery of rare earth elements (REEs). In this study, Escherichia coli (E. coli) was chemically modified to improve its performance as a biosorbent for REEs. The diglycolic amic acid group, which shows high affinity to REEs, was introduced by succinylation of the amine groups on the E. coli. Adsorption curves using the modified E. coli were characteristic of the diglycolic amic acid group. The adsorption performance for transition metal ions was not affected by the modification. These results suggest that modification of E. coli with a functional group with high affinity to REEs increases the effectiveness of adsorption. The maximum uptakes of REEs on the modified E. coli were doubled. Modification of E. coli is an effective method for enhancing the adsorption performance for REEs.

    DOI: 10.1016/j.bej.2016.06.005

  • Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids Reviewed International journal

    Furukawa, Shin-ya, Hattori, Gaku, Sakai, Shinji, Kamiya, Noriho

    RSC Adv.   6   87753 - 87755   2016.9

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    DOI: 10.1039/C6RA16926K

  • Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass Reviewed International journal

    Uju, Masahiro Goto, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   214   487 - 495   2016.8

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    DOI: 10.1016/j.biortech.2016.04.121

  • Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass

    Uju, Uju, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Bioresource Technology   214   487 - 495   2016.8

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    Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass
    © 2016 Elsevier Ltd. The aim of this work was to design a new method for the efficient saccharification of lignocellulosic biomass (LB) using a combination of peracetic acid (PAA) pretreatment with ionic liquid (IL)-HCl hydrolysis. The pretreatment of LBs with PAA disrupted the lignin fractions, enhanced the dissolution of LB and led to a significant increase in the initial rate of the IL-HCl hydrolysis. The pretreatment of Bagasse with PAA prior to its 1-buthyl-3-methylimidazolium chloride ([Bmim][Cl])-HCl hydrolysis, led to an improvement in the cellulose conversion from 20% to 70% in 1.5 h. Interestingly, the 1-buthyl-3-methylpyridium chloride ([Bmpy][Cl])-HCl hydrolysis of Bagasse gave a cellulose conversion greater than 80%, with or without the PAA pretreatment. For LB derived from seaweed waste, the cellulose conversion reached 98% in 1 h. The strong hydrolysis power of [Bmpy][Cl] was attributed to its ability to transform cellulose I to II, and lowering the degree of polymerization of cellulose.

    DOI: 10.1016/j.biortech.2016.04.121

  • Self-assembly of Ni-NTA-modified beta-annulus peptides into artificial viral capsids and encapsulation of His-tagged proteins Reviewed International journal

    Kazunori Matsuura, Tomohiro Nakamura, Kenta Watanabe, Takanori Noguchi, Kosuke Minamihata, Kamiya, Noriho, Nobuo Kimizuka

    Org. Biomol. Chem.   14   7869 - 7874   2016.8

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    DOI: 10.1039/C6OB01227B

  • High-level expression and purification of biologically active human IL-2 using silkworm-baculovirus expression vector system Reviewed International journal

    Masato Hino, Takuji Kawanami, Noriho Kamiya, Tsuneyuki Tatsuke, Yutaka Banno, Takahiro Kusakabe, JAE MAN LEE

    JOURNAL OF ASIA-PACIFIC ENTOMOLOGY   19 ( 2 )   313 - 317   2016.6

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    DOI: 10.1016/j.aspen.2016.03.014

  • High-level expression and purification of biologically active human IL-2 using silkworm-baculovirus expression vector system Reviewed

    Hino Masato, Kawanami Takuji, Xu Jian, Morokuma Daisuke, Hirata Kazuma, Yamashita Mami, Karasaki Noriko, Tatsuke Tuneyuki, Mon Hiroaki, Iiyama Kazuhiro, Kamiya Noriho, Banno Yutaka, Kusakabe Takahiro, Lee Jae Man

    JOURNAL OF ASIA-PACIFIC ENTOMOLOGY   19 ( 2 )   313 - 317   2016.6

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    High-level expression and purification of biologically active human IL-2 using silkworm-baculovirus expression vector system

    DOI: 10.1016/j.aspen.2016.03.014

  • Enzymatic conjugation of multiple proteins on a DNA aptamer in a tail-specific manner

    Mari Takahara, Kounosuke Hayashi, Kounosuke Hayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Biotechnology Journal   11   814 - 823   2016.6

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    Enzymatic conjugation of multiple proteins on a DNA aptamer in a tail-specific manner
    Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Conjugation of single-strand DNA aptamers and enzymes has been of great significance in bioanalytical and biomedical applications because of the unlimited functions provided by DNA aptamer direction. Therefore, we developed efficient tailing of a DNA aptamer, with end-specific conjugation of multiple enzymes, through enzymatic catalysis. Terminal deoxynucleotidyl transferase (TdT) added multiple Z-Gln-Gly (Z-QG) moieties to the 3′-end of a DNA aptamer via the addition of Z-QG-modified deoxyuridine triphosphate (Z-QG-dUTP) and deoxynucleoside triphosphates (dNTPs). The resultant (Z-QG)m-(dN)l-aptamer, whose Z-QGs with dN spacers served as stickers for microbial transglutaminase (MTG), were crosslinked between the Z-QGs on the DNA and a substrate peptide sequence containing lysine (K), fused to a recombinant enzyme (i.e. bacterial alkaline phosphatase; BAP) by MTG. The incorporation efficiency of Z-QG moieties on the aptamer tail and the subsequent conjugation efficiency with multiple enzyme molecules were dramatically altered by the presence of dNTPs, revealing that a combination of Z-QG-dUTP/dTTP comprised the best labeling efficiency and corresponding properties during analytical performance. Thus, a novel optimized platform for designing (BAP)n-(dT)l-DNA aptamers was demonstrated for the first time in this article, offering unique opportunities for tailoring new types of covalent protein-nucleic acid conjugates in a controllable way.

    DOI: 10.1002/biot.201500560

  • Enzymatic conjugation of multiple proteins on a DNA aptamer in a tail-specific manner Reviewed International journal

    Takahara, Mari, Hayashi, Kounosuke, Masahiro Goto, Kamiya, Noriho

    BIOTECHNOLOGY JOURNAL   11 ( 6 )   814 - 823   2016.6

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    DOI: 10.1002/biot.201500560

  • BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells Reviewed International journal

    Akira Tsuchiya, Siti Norulhuda Hashim, Ise, Shoko, Furuhata, Takafumi, Rie Wakabayashi, Masahiro Goto, Kawai, Kiyohiko, Noriho Kamiya, Shinsuke Sando

    ANALYTICAL SCIENCES   32 ( 5 )   543 - 547   2016.5

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  • Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids Reviewed

    Shin Ya Furukawa, Gaku Hattori, Shinji Sakai, Noriho Kamiya

    RSC Advances   6 ( 90 )   87753 - 87755   2016.1

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    DOI: 10.1039/c6ra16926k

  • Substrate engineering of microbial transglutaminase for site-specific protein modification and bioconjugation Reviewed

    Noriho Kamiya, Yutaro Mori

    Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery   373 - 383   2016.1

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    DOI: 10.1007/978-4-431-55825-5_17

  • Self-assembly of Ni-NTA-modified β-annulus peptides into artificial viral capsids and encapsulation of His-tagged proteins Reviewed

    14   7869 - 7874   2016.1

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    © The Royal Society of Chemistry 2016. β-Annulus peptides bearing Cys at the N-terminal from tomato bushy stunt virus were synthesised using a standard Fmoc-protected solid-phase method, and the peptide was modified with Ni-NTA at the N-terminal. The Ni-NTA-modified β-annulus peptide self-assembled into virus-like nanocapsules of approximately 40 nm in diameter. The critical aggregation concentration of these nanocapsules in 10 mM Tris-HCl buffer (pH 7.3) at 25 °C was 0.053 μM, which is 470 times lower than that of unmodified β-annulus peptides. Moreover, size exclusion chromatography of the peptide assembly indicated encapsulation of His-tagged green fluorescent protein in the Ni-NTA-modified artificial viral capsid.

    DOI: 10.1039/c6ob01227b

  • Selective extraction of scandium from transition metals by synergistic extraction with 2-thenoyltrifluoroacetone and tri-n-octylphosphine oxide

    Zhigang Zhao, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Solvent Extraction Research and Development   23   137 - 143   2016.1

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    Selective extraction of scandium from transition metals by synergistic extraction with 2-thenoyltrifluoroacetone and tri-n-octylphosphine oxide
    There has been an increasing demand for scandium (Sc). However the supply is insufficient because the separation and recovery of Sc as a byproduct from ores is difficult. In this study, extraction and separation of Sc3+from a sulfuric acid solution containing transition metals such as Al3+, Fe3+, Mn2+, Co2+, Ni2+and Zn2+was investigated using a β-diketone, HTTA and a neutral extractant, TOPO. Due to the synergistic effect with the two extractants, Sc3+was effectively and selectively separated even from Fe3+, the separation of which is difficult with HTTA alone. The extraction mechanism was examined and it was revealed that Sc3+is extracted with three HTTA and one TOPO molecules. Scandium was readily stripped from the extracting phase by 1 M sulfuric acid. The potential use of the combination of the β-diketone with TOPO for the recovery of Sc3+in a refining process was demonstrated.

    DOI: 10.15261/serdj.23.137

  • Mutual separation of indium, gallium, and zinc with the amic acid-type extractant D2EHAG containing glycine and amide moieties

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Solvent Extraction Research and Development   23   9 - 18   2016.1

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    Mutual separation of indium, gallium, and zinc with the amic acid-type extractant D2EHAG containing glycine and amide moieties
    Solvent extraction of indium (In3+), gallium (Ga3+), and zinc (Zn2+) was investigated using N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]glycine (D2EHAG) and N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]-sarcosine (D2EHAS) which we have developed recently. Indium and gallium were selectively extracted from zinc under high acid conditions (0 > pH ≥ 2.0), and easily stripped using an acidic solution such as 2 mol dm-3 HNO3. The extraction behavior was compared to that of N,N-dioctyldiglycol amic acid (DODGAA), which has a similar molecular structure to D2EHAG, a commercial alkyl monocarboxylic acid extractant, neodecanoic acid (Versatic 10), or an organophosphorus extractant, di(2-ethylhexyl) phosphoric acid (D2EHPA). Based on the results, D2EHAG and D2EHAS were found to be useful for the separation of In3+ and Ga3+ from Zn2+. The extraction mechanisms of these ions with D2EHAG were investigated through slope analysis and loading tests.

    DOI: 10.15261/serdj.23.9

  • Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells

    Yukiho Hosomomi, Teppei Niide, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Analytical Sciences   32   295 - 300   2016.1

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    Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells
    © The Japan Society for Analytical Chemistry. A novel strategy for the preparation of protein-decorated gold nanoparticles (Au NPs) was developed inside Escherichia coli cells, where an artificial oxidoreductase, composed of antibody-binding protein (pG), Bacillus stearothermophilus glycerol dehydrogenase (BsGLD) and a peptide tag with gold-binding affinity (H6C), was overexpressed in the cytoplasm. In situ formation of Au NPs was promoted by a natural electron-donating cofactor, nicotinamide adenine dinucleotide (NAD), which was regenerated to the reduced form of NADH by the catalytic activity of the fusion protein (pG-BsGLDH6C) overexpressed in the cytoplasm of E. coli, with the concomitant addition of exogenous glycerol to the reaction system. The fusion protein was self-immobilized on Au NPs inside the E. coli cells, which was confirmed by SDS-PAGE and western blotting analyses of the resultant Au NPs. Finally, the IgG binding ability of the pG moiety displayed on Au NPs was evaluated by an enzyme-linked immunosorbent assay. 2016

    DOI: 10.2116/analsci.32.295

  • BODIPY-labeled fluorescent aptamer sensors for turn-on sensing of interferon-gamma and adenine compounds on cells

    Akira Tsuchiya, Siti N. Hashim, Shoko Ise, Takafumi Furuhata, Kiyohiko Kawai, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya, Shinsuke Sando

    Analytical Sciences   32   543 - 547   2016.1

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    BODIPY-labeled fluorescent aptamer sensors for turn-on sensing of interferon-gamma and adenine compounds on cells
    © The Japan Society for Analytical Chemistry. An on-cell aptamer sensor has the potential to reveal cell-cell communications by signalling molecules. We attempted to design new fluorescent aptamer sensors for the sensing of IFN-? and adenine compounds on cells. BODIPY-labeled external quencher-free aptamer sensors have allowed a turn-on detection of the target molecule with improved off/on efficiency.

    DOI: 10.2116/analsci.32.543

  • Substrate engineering of microbial transglutaminase for site-specific protein modification and bioconjugation

    Noriho Kamiya, Yutaro Mori

    Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery   373 - 383   2016.1

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    Language:English  

    DOI: 10.1007/978-4-431-55825-5_17

  • Self-assembly of Ni-NTA-modified β-annulus peptides into artificial viral capsids and encapsulation of His-tagged proteins Reviewed

    14 ( 33 )   7869 - 7874   2016.1

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    β-Annulus peptides bearing Cys at the N-terminal from tomato bushy stunt virus were synthesised using a standard Fmoc-protected solid-phase method, and the peptide was modified with Ni-NTA at the N-terminal. The Ni-NTA-modified β-annulus peptide self-assembled into virus-like nanocapsules of approximately 40 nm in diameter. The critical aggregation concentration of these nanocapsules in 10 mM Tris-HCl buffer (pH 7.3) at 25 °C was 0.053 μM, which is 470 times lower than that of unmodified β-annulus peptides. Moreover, size exclusion chromatography of the peptide assembly indicated encapsulation of His-tagged green fluorescent protein in the Ni-NTA-modified artificial viral capsid.

    DOI: 10.1039/c6ob01227b

  • BODIPY-labeled fluorescent aptamer sensors for turn-on sensing of interferon-gamma and adenine compounds on cells Reviewed

    Akira Tsuchiya, Siti N. Hashim, Shoko Ise, Takafumi Furuhata, Kiyohiko Kawai, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Shinsuke Sando

    analytical sciences   32 ( 5 )   543 - 547   2016

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    DOI: 10.2116/analsci.32.543

  • Selective extraction of scandium from transition metals by synergistic extraction with 2-thenoyltrifluoroacetone and tri-n-octylphosphine oxide Reviewed

    Zhigang Zhao, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   23 ( 2 )   137 - 143   2016

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    DOI: 10.15261/serdj.23.137

  • One-dimensional assembly of functional proteins Toward the design of an artificial cellulosome Reviewed

    Molecular Systems Design and Engineering   1 ( 1 )   66 - 73   2016

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    DOI: 10.1039/c5me00011d

  • Mutual separation of indium, gallium, and zinc with the amic acid-type extractant D2EHAG containing glycine and amide moieties Reviewed

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   23 ( 1 )   9 - 18   2016

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    DOI: 10.15261/serdj.23.9

  • Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells Reviewed

    Yukiho Hosomomi, Teppei Niide, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    analytical sciences   32 ( 3 )   295 - 300   2016

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    DOI: 10.2116/analsci.32.295

  • Transcutaneous Peptide Immunotherapy of Japanese Cedar Pollinosis Using Solid-in-Oil Nanodispersion Technology Invited Reviewed International journal

    AAPS PHARMSCITECH   16 ( 6 )   1418 - 1424   2015.12

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    DOI: 10.1208/s12249-015-0333-x

  • Transcutaneous Peptide Immunotherapy of Japanese Cedar Pollinosis Using Solid-in-Oil Nanodispersion Technology International journal

    Momoko Kitaoka, Yoko Shin, Noriho Kamiya, Noriho Kamiya, Yoshinori Kawabe, Masamichi Kamihira, Masahiro Goto, Masahiro Goto

    AAPS PharmSciTech   16 ( 6 )   1418 - 1424   2015.12

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    Transcutaneous Peptide Immunotherapy of Japanese Cedar Pollinosis Using Solid-in-Oil Nanodispersion Technology
    © 2015, American Association of Pharmaceutical Scientists. Peptide immunotherapy is an attractive approach to relieve allergic symptoms such as rhinitis and asthma. Treatment of Japanse cedar pollinosis (Cryptomeria japonica; Cj), from which over one quarter of Japanese population suffer, is becoming a great concern. Recently, oral feeding of a peptide (7crp) consisting of seven immunodominant human T cell epitopes derived from two enzymes present in Cj pollen was demonstrated to have a benefit in treating Cj pollinosis. In this work, we aimed to apply a novel transcutaneous administration system as a simple and easy peptide delivery for an immunotherapy using a T cell epitope peptide. A modified 7crp peptide (7crpR) which contained triarginine linkers between each epitopes was designed to increase water solubility and was encapsulated in a unique solid-in-oil (S/O) nanodispersion. The S/O nanodispersion consists of a nano-sized peptide-surfactant complex dispersed in an oil vehicle. The S/O nanopartilces having an average diameter of 230 nm facilitated the permeation of the peptide 7crpR into the skin and suppressed serum total IgE and antigen-specific IgE levels in a Cj pollinosis mouse model. Transcutaneous administration of the T cell epitope peptide using the S/O nanodispersion system has potential for future simple and easy immunotherapy of Cj pollinosis.

    DOI: 10.1208/s12249-015-0333-x

  • A Single Fluorophore-labeled Aptamer Sensor for the Detection of Interferon Gamma Reviewed

    Siti Norulhuda Hashim, Akira Tsuchiya, Noriho Kamiya, Shinsuke Sando

    CHEMISTRY LETTERS   44 ( 12 )   1670 - 1672   2015.12

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    DOI: 10.1246/cl.150794

  • A Single Fluorophore-labeled Aptamer Sensor for the Detection of Interferon Gamma Reviewed International journal

    Siti Norulhuda Hashim, Akira Tsuchiya, Noriho Kamiya, Shinsuke Sando

    Chem. Lett.   44 ( 12 )   1670 - 1672   2015.12

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  • Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions Reviewed International journal

    MedChemComm   6   2124 - 2128   2015.12

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  • Great potency of seaweed waste biomass from the carrageenan industry for bioethanol production by peracetic acid-ionic liquid pretreatment Reviewed International journal

    BIOMASS & BIOENERGY   81   63 - 69   2015.10

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    DOI: 10.1016/j.biombioe.2015.05.023

  • Heme precursor injection is effective for Arthromyces ramosus peroxidase fusion protein production by a silkworm expression system Reviewed

    Hayashi Kounosuke, Lee Jae Man, Tomozoe Yusuke, Kusakabe Takahiro, Kamiya Noriho

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   120 ( 4 )   384 - 386   2015.10

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    Heme precursor injection is effective for Arthromyces ramosus peroxidase fusion protein production by a silkworm expression system

    DOI: 10.1016/j.jbiosc.2015.02.013

  • Great potency of seaweed waste biomass from the carrageenan industry for bioethanol production by peracetic acid-ionic liquid pretreatment

    Uju, Uju, Agung Tri Wijayanta, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Biomass and Bioenergy   81   63 - 69   2015.10

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    Great potency of seaweed waste biomass from the carrageenan industry for bioethanol production by peracetic acid-ionic liquid pretreatment
    © 2015 Published by Elsevier Ltd. Seaweed waste biomass from the carrageenan industry (SWBC) is a potential biomass feedstock for producing sustainable biofuel because it increases the product value and reduces the pollutant risk. Peracetic acid (PAA) followed by ionic liquid (IL) pretreatment has been used to increase the enzymatic saccharification of pretreated SWBC. The SWBC cellulose content was comparable with that of terrestrial biomasses. PAA+1-hexylpyridinium chloride ([Hpy][Cl]), and PAA+1-ethyl-3-methylimidazolium diethylphosphate ([Emim][DEP]) pretreatments produced saccharide and unknown oligosaccharide fractions in regenerated water (~4-6% SWBC cellulose content). For 48h of saccharification, the untreated SWBC and the SWBC pretreated using PAA followed by [Hpy][Cl], [Emim][DEP] or 1-ethyl-3-methylimidazole acetate ([Emim][OAc]) produced cellulose conversions of 77, 91, 84 and 62%, respectively. The untreated SWBC had a high cellulose conversion, which may be caused by the low lignin and hemicellulose contents of the SWBC. PAA+IL pretreatment could yield pretreated SWBCs with more amorphous cellulose structures, which lead to an almost-complete cellulose conversion.

    DOI: 10.1016/j.biombioe.2015.05.023

  • Transcutaneous immunization against cancer using solid-in-oil nanodispersions Reviewed International journal

    MedChemComm   6   1387 - 1392   2015.7

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  • Transcutaneous immunization against cancer using solid-in-oil nanodispersions

    Yuya Hirakawa, Rie Wakabayashi, Rie Wakabayashi, Ayaka Naritomi, Masato Sakuragi, Noriho Kamiya, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto, Masahiro Goto

    MedChemComm   6   1387 - 1392   2015.7

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    Transcutaneous immunization against cancer using solid-in-oil nanodispersions
    © The Royal Society of Chemistry. Transcutaneous immunization is a novel, non-invasive alternative to conventional immunization by injection. Skin immunocompetence composed of abundant antigen-presenting cells in the epidermal and dermal layers of the skin can provide an effective tool for transcutaneous immunization, whereas the outermost, hydrophobic layer of skin, the stratum corneum, hinders the penetration of antigens into the skin. To realize effective transcutaneous delivery of antigens, we have developed a solid-in-oil (S/O) technique that produces an oil dispersion of hydrophilic biomolecules. In this study, we applied the S/O nanodispersions in transcutaneous immunization to induce cancer immunity. The topical application of S/O nanodispersions bearing ovalbumin (OVA) as a model cancer-antigen allowed the penetration of OVA into the deep dermis region of the skin by intercellular and transfollicular pathways. Inhibition of OVA-bearing tumor growth and production of cytokines responsible for cellular immunity were achieved, demonstrating the applicability of S/O nanodispersions to the induction of cancer immunity.

    DOI: 10.1039/c5md00168d

  • Transcutaneous immunization against cancer using solid-in-oil nanodispersions Reviewed

    Yuya Hirakawa, Rie Wakabayashi, Ayaka Naritomi, Masato Sakuragi, Noriho Kamiya, Masahiro Goto

    MedChemComm   6 ( 7 )   1387 - 1392   2015.7

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    DOI: 10.1039/c5md00168d

  • Effect of pretreatment methods on the synergism of cellulase and xylanase during the hydrolysis of bagasse Reviewed

    Lili Jia, Geisa A.L. Goncalves, Yusaku Takasugi, Yutaro Mori, Shuhei Noda, Tsutomu Tanaka, Hirofumi Ichinose, Noriho Kamiya

    Bioresource Technology   185   158 - 164   2015.6

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    Effect of pretreatment methods on the synergism of cellulase and xylanase during the hydrolysis of bagasse

    DOI: 10.1016/j.biortech.2015.02.041

  • Synergistic effect and application of xylanases as accessory enzymes to enhance the hydrolysis of pretreated bagasse Reviewed International journal

    ENZYME AND MICROBIAL TECHNOLOGY   72   2015.5

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    DOI: 10.1016/j.enzmictec.2015.01.007

  • Synergistic effect and application of xylanases as accessory enzymes to enhance the hydrolysis of pretreated bagasse. Reviewed

    Enzyme and microbial technology   72   16 - 24   2015.5

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    Synergistic effect and application of xylanases as accessory enzymes to enhance the hydrolysis of pretreated bagasse.

    DOI: 10.1016/j.enzmictec.2015.01.007

  • Transdermal immunization using solid-in-oil nanodispersion with CpG oligodeoxynucleotide adjuvants Reviewed

    Momoko Kitaoka, Ayaka Naritomi, Yuya Hirakawa, Noriho Kamiya, Masahiro Goto

    Pharmaceutical Research   32 ( 4 )   1486 - 1492   2015.4

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    DOI: 10.1007/s11095-014-1554-5

  • Development of a peroxidase-Fused protein reagent by brevibacillus choshinensis heterologous expression system Reviewed

    Kounosuke Hayashi, Yusuke Tomozoe, Kenji Nagai, Yoshiyuki Hiraishi, Noriho Kamiya

    kagaku kogaku ronbunshu   41 ( 2 )   157 - 161   2015.3

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    DOI: 10.1252/kakoronbunshu.41.157

  • Separation of gold(III) in acidic chloride solution using porous polymeric ionic liquid gel Reviewed

    Jian Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   48 ( 3 )   197 - 201   2015.3

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    DOI: 10.1252/jcej.14we162

  • ブレビバチルス発現系によるペルオキシダーゼ融合タンパク質試薬の調製 Reviewed

    林 浩之輔, 友添祐介, 永井賢治, 平石佳之, 神谷 典穂

    化学工学論文集   41 ( 2 )   157 - 161   2015.2

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  • Transglutaminase-mediated in situ hybridization (transish) for mRNA detection in mammalian tissues Reviewed

    Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    In Situ Hybridization Methods   549 - 558   2015.2

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    DOI: 10.1007/978-1-4939-2303-8_29

  • Transglutaminase-mediated in situ hybridization (transish) for mRNA detection in mammalian tissues

    Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    In Situ Hybridization Methods   549 - 558   2015.2

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    DOI: 10.1007/978-1-4939-2303-8_29

  • 固相免疫測定法を目的とした融合タンパク質試薬の設計とヒト培養細胞による生産プロセスの最適化 Reviewed

    林 浩之輔, 友添祐介, 永井賢治, 松葉恭一, 平石佳之, 松村外志張, 上田 宏, 神谷 典穂

    化学工学論文集   41 ( 1 )   38 - 42   2015.1

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  • Transdermal immunization using solid-in-oil nanodispersion with CpG oligodeoxynucleotide adjuvants

    Momoko Kitaoka, Ayaka Naritomi, Yuya Hirakawa, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Pharmaceutical Research   32   1486 - 1492   2015.1

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    Transdermal immunization using solid-in-oil nanodispersion with CpG oligodeoxynucleotide adjuvants
    © 2014 Springer Science+Business Media New York. Purpose: Simple and noninvasive vaccine administration alternatives to injections are desired. A solid-in-oil (S/O) nanodispersion system was able to overcome skin barriers and induce an immune response; however, antibody levels remained low. We applied an immune potentiator, CpG oligodeoxynucleotide (ODN), to enhance the immune response by controlling the T helper 1 (Th1)/T helper 2 (Th2) balance. Methods: S/O nanodispersions containing ovalbumin (OVA) and CpG ODN (CpG-A or CpG-B) were characterized by size distribution analysis and a protein release test. The skin permeation of fluorescence-labeled OVA was observed by fluorescence microscopy. Antigen-specific IgG, IgG1, and IgG2a responses were measured by enzyme-linked immunosorbent assay. Results: Co-encapsulation of CpG ODNs in S/O nanodispersions enhanced induction of OVA-specific IgG. S/O nanodispersion containing OVA and CpG-A had a smaller mean particle size and permeated the skin more efficiently. In contrast, CpG-B showed the highest protein release and induction of OVA-specific IgG. IgG subclass analysis revealed that OVA induced a Th2-dominant immune response, while the S/O nanodispersion containing CpG-A skewed the immune response toward a Th1-bias. Conclusions: In combination with CpG ODN, the S/O nanodispersion system efficiently induced an antigen-specific antibody response. The Th1/Th2 immune balance could be controlled by the selection of CpG ODN type.

    DOI: 10.1007/s11095-014-1554-5

  • Site-specific conjugation of an antibody-binding protein catalyzed by horseradish peroxidase creates a multivalent protein conjugate with high affinity to IgG

    Kosuke Minamihata, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Biotechnology Journal   10   222 - 226   2015.1

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    Site-specific conjugation of an antibody-binding protein catalyzed by horseradish peroxidase creates a multivalent protein conjugate with high affinity to IgG
    © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Cross-linking proteins offers an approach to enhance the distinct function of proteins due to the multivalent effect. In this study, we demonstrated the preparation of a multivalent antibody-binding protein possessing high affinity to IgG by conjugating a number of antibody-binding proteins using the horseradish peroxidase (HRP)-mediated protein conjugation method. By introducing a peptide tag containing a tyrosine (Y-tag) to the C-terminus of the model protein, a chimera protein of protein G and protein A (pG2pA), the Tyr residue in the Y-tag was efficiently recognized by HRP and cross-linked with each other to yield a pG2pA conjugate, composed of mainly two to three units of pG2pA. The cross-linking occurred site specifically at the Tyr residue in the Y-tag and introduction of the Y-tag showed no effect on the function of pG2pA. The affinity of the Y-tagged pG2pA conjugate against IgG clearly increased because of the multivalent effect, demonstrating the benefit of this protein cross-linking reaction, which yields functional protein oligomers. Such multivalent protein conjugates created by this reaction should have potential to be used in ELISA and Western blotting applications in which highly sensitive detection of target molecules is desired.

    DOI: 10.1002/biot.201400512

  • Separation of gold(III) in acidic chloride solution using porous polymeric ionic liquid gel

    Jian Yang, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Journal of Chemical Engineering of Japan   48   197 - 201   2015.1

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    Separation of gold(III) in acidic chloride solution using porous polymeric ionic liquid gel
    © 2015 The Society of Chemical Engineers, Japan. A novel polymeric ionic liquid (PIL) gel was synthesized via radical polymerization of the ionic liquid monomers, 1-vinyl- 3-ethylimidazoliumbis(trifluorometyl-sulfonyl) imide ([veim][Tf2N]). The gel was made porous by removing the water phase dispersed by polyoxyethylene (20) sorbitan monolaurate (Tween-20). The porous structure of the synthesized gel was observed by SEM imaging. In comparison to the nonporous PIL gel synthesized without Tween-20, the adsorption capacity of Au(III) onto porous PIL gel was enhanced. The adsorption behavior of the synthesized gel was studied in acidic chloride solutions containing various metal ions, and it was found that the gel selectively adsorbed Au(III) over other metal ions. Maximum adsorption capacity of Au(III) was more than 140 mg/g; whereas, those for Pt(IV) and Pd(II) were lower than 20 mg/g. The adsorbed Au(III) onto the gel can easily be desorbed using an acidified thiourea aqueous solution. The feasibility of utilizing the polymeric ionic liquid gel for the separation of Au(III) was thereby demonstrated.

    DOI: 10.1252/jcej.14we162

  • Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions

    Shota Araki, Rie Wakabayashi, Rie Wakabayashi, Muhammad Moniruzzaman, Noriho Kamiya, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto, Masahiro Goto

    MedChemComm   6   2124 - 2128   2015.1

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    Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions
    © 2015 The Royal Society of Chemistry. As a potentially safe and non-invasive vaccination method, transcutaneous immunization represents an attractive alternative to conventional vaccine delivery by injection. However, the development of transcutaneous immunization has remained a challenge for a large number of hydrophilic macromolecules including protein and peptide antigens. We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil (S/O) nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of the IL [C12mim][Tf2N] (1-dodecyl-3-methyl imidazolium bis(trifluoromethyl sulfonyl) amide) as a penetration enhancer in the formulation significantly enhanced the skin permeability of ovalbumin (OVA), a model antigen. It was also found that the IL-mediated S/O nanodispersion obtained high levels of OVA-specific serum IgG compared with both S/O nanodispersions without IL and PBS control. These findings clearly indicate that ILs-which are potentially attractive "green" and "designer" solvents-could serve as potential skin penetration enhancers in transcutaneous vaccination for hydrophilic macromolecules.

    DOI: 10.1039/c5md00378d

  • Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms

    Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    RSC Advances   5   3070 - 3073   2015.1

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    Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms
    © The Royal Society of Chemistry 2015. A redox-responsive hydrogel composed of poly(ethylene glycol) and gelatin was prepared via an enzymatic oxidative reaction. Fibroblast cells adhered on the hydrogel showed proliferation and they could be recovered as a cell sheet by degradation of the scaffold under mild reductive conditions, thus providing a novel platform for cell culture.

    DOI: 10.1039/c4ra12334d

  • Activity and stability of enzyme immobilized with ionic liquid based polymer materials

    M. Moniruzzaman, H. Mahmood, N. Kamiya, S. Yusup, M. Goto

    Journal of Engineering Science and Technology   10   60 - 69   2015.1

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    Activity and stability of enzyme immobilized with ionic liquid based polymer materials
    © School of Engineering, Taylor’s University. Enzyme immobilization methods are continuously being developed for a wide range of applications including biocatalysis and biotransformation. Compared to other immobilization methods, physical entrapment into a matrix is relatively simple and inexpensive, and causes a relatively small perturbation to the native enzyme structure and function. However, significant enzyme leaching from such biocatalytic polymers is the main constraint in using them for industrial levels. This study reports an ionic liquid (IL) polymer materials incorporating enzymes that can be used as active, stable and reusable biocatalysts to overcome the limitations. Lipase was microencapsulated in surfactant aggregates formed in an IL monomer or the solution of an IL monomer/IL and then incorporated into polymer frameworks through the free radical polymerization of an IL (1-vinyl-3-ethylimidazolium bis(trifluoromethylsulfonyl) amide ([veim][Tf2N]). The activity, stability and reusability of IL polymer materials containing lipase were evaluated using lipase-catalyzed hydrolysis of p-nitrophenyl butyrate (p-PNB) as a model reaction. It was found that lipase IL polymer materials exhibited excellent stability in aqueous solutions. More importantly, these biopolymer materials retained most of their activity after six reaction cycles. We firmly believe that enzyme containing IL polymeric materials developed in this study will provide several advantages over conventional polymer based methods for diverse enzymatic reactions.

  • Transglutaminase-mediated in situ hybridization (TransISH) for mRNA detection in mammalian tissues Reviewed

    Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    Neuromethods   99   549 - 558   2015.1

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    DOI: 10.1007/978-1-4939-2303-8_29

  • Optimization of a fusion protein expression system using human cell lines to create a practical immunoassay reagent Reviewed

    Kounosuke Hayashi, Yusuke Tomozoe, Kenji Nagai, Kyoichi Matsuba, Masayuki Mitsumori, Yoshiyuki Hiraishi, Toshiharu Matsumura, Hiroshi Ueda, Noriho Kamiya

    kagaku kogaku ronbunshu   41 ( 1 )   38 - 42   2015.1

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    DOI: 10.1252/kakoronbunshu.41.38

  • Activity and stability of enzyme immobilized with ionic liquid based polymer materials Reviewed

    M. Moniruzzaman, H. Mahmood, Noriho Kamiya, S. Yusup, Masahiro Goto

    Journal of Engineering Science and Technology   10   60 - 69   2015.1

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  • A single fluorophore-labeled aptamer sensor for the detection of interferon gamma Reviewed

    Siti Norulhuda Hashim, Akira Tsuchiya, Noriho Kamiya, Shinsuke Sando

    Chemistry Letters   44 ( 12 )   1670 - 1672   2015.1

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    DOI: 10.1246/cl.150794

  • Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions Reviewed

    Shota Araki, Rie Wakabayashi, Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    MedChemComm   6 ( 12 )   2124 - 2128   2015

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    DOI: 10.1039/c5md00378d

  • Biomolecular assembly strategies to develop potential artificial cellulosomes

    Sustainable Chemical Processes   2 ( 1 )   2014.12

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    DOI: 10.1186/s40508-014-0019-9

  • A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells Reviewed

    Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya, Masahiro Goto

    MedChemComm   5 ( 10 )   1515 - 1519   2014.10

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    DOI: 10.1039/c4md00179f

  • Application of cellulose acetate to the selective adsorption and recovery of Au(III)

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Carbohydrate Polymers   111   768 - 774   2014.10

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    Application of cellulose acetate to the selective adsorption and recovery of Au(III)
    Cellulose acetyl derivatives were examined for the selective recovery of Au(III) from acidic chloride solutions as an adsorbent, and cellulose acetate fibers (CAF) were found to be effective for the separation of Au(III) from other metal ions, including the precious metal ions Pt(IV) and Pd(II). The amount of Au(III) adsorbed by the fibers increased with an increase in the hydrochloric acid concentration, but decreased with an increase in the ionic strength of the solution. The adsorption of Au(III) onto CAF took place quickly and an adsorption equilibrium was reached within 1 h. The maximum adsorption capacity of Au(III) was determined to be 110 mg/g at 2 M hydrochloric acid. The loaded Au(III) was readily recovered by incineration. © 2014 Elsevier Ltd.

    DOI: 10.1016/j.carbpol.2014.05.003

  • A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

    Rie Wakabayashi, Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto, Masahiro Goto

    MedChemComm   5   1515 - 1519   2014.10

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    A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells
    © 2014 the Partner Organisations. In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT). Using emulsification and freeze-drying processes in the presence of a hydrophilic surfactant, Pluronic F-68 or F-127, CPT-Pluronic complexes with crystalline features were synthesised. Investigation of the in vitro anticancer activities and cellular internalisation of the complexes revealed that the SCN efficiently delivered CPT to cells while maintaining anticancer activity.

    DOI: 10.1039/c4md00179f

  • Application of cellulose acetate to the selective adsorption and recovery of Au(III) Reviewed

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    Carbohydrate Polymers   111   768 - 774   2014.10

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    DOI: 10.1016/j.carbpol.2014.05.003

  • Characterization of enzymatically gellable, phenolated linear poly(ethylene glycol) with different molecular weights for encapsulating living cells Reviewed

    Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Biochemical Engineering Journal   93   25 - 30   2014.9

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    DOI: 10.1016/j.bej.2014.09.003

  • Characterization of enzymatically gellable, phenolated linear poly(ethylene glycol) with different molecular weights for encapsulating living cells

    Kousuke Moriyama, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Biochemical Engineering Journal   93   25 - 30   2014.9

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    Characterization of enzymatically gellable, phenolated linear poly(ethylene glycol) with different molecular weights for encapsulating living cells
    © 2014 Elsevier B.V. Enzymatic hydrogelation has received much attention due to the high biocompatibility and the ease of control of reaction kinetics under physiological conditions. In particular, horseradish peroxidase (HRP)-mediated phenol coupling reaction has great potential for developing in situ hydrogelation systems. Herein, we report the HRP-catalyzed preparation and characterization of hydrogels composed of a terminally bis-phenolated linear poly(ethylene glycol) (PEG-Ph-OH) with different molecular weights (Mws 3100, 8800, 11,000, 20,000g/mol). The gelation time of polymer solution can be controlled in the range from few second to few minute, suggestion that the PEG-Ph-OH has a potential as a in situ forming hydrogel. In addition, the physicochemical properties of the hydrogels, such as swelling ratio, mesh size and mechanical property, were controlled by the molecular weight of the PEG-Ph-OH. The results could be attributed to the alteration in the cross-linking density by the variation of molecular weight of the gel precursor. Furthermore, the viability of mammalian cells encapsulated in the PEG-Ph-OH hydrogels was approximately 90%. These results indicate that PEG-Ph-OH has potential for biomedical applications including tissue engineering.

    DOI: 10.1016/j.bej.2014.09.003

  • Synergistic Extraction of Rare-Earth Metals and Separation of Scandium Using 2-Thenoyltriuoroacetone and Tri-n-octylphosphine Oxide in an Ionic Liquid System

    Zhigang Zhao, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   656 - 662   2014.8

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    DOI: 10.1252/jcej.14we360

  • The Self-Assembly and Secondary Structure of Peptide Amphiphiles Determine the Membrane Permeation Activity Reviewed International journal

    RSC Advances   4   2014.7

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  • A Novel Surface-Coated Nanocarrier for Efficient Encapsulation and Delivery of Camptothecin to Cells Reviewed International journal

    MedChemComm   5   2014.7

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  • Development of Novel Extractants with Amino Acid Structure for Efficient Separation of Nickel and Cobalt from Manganese Ions Reviewed International journal

    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH   53 ( 2 )   2014.1

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    DOI: 10.1021/ie403524a

  • The self-assembly and secondary structure of peptide amphiphiles determine the membrane permeation activity

    Rie Wakabayashi, Yuko Abe, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto, Masahiro Goto

    RSC Advances   4   30654 - 30657   2014.1

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    The self-assembly and secondary structure of peptide amphiphiles determine the membrane permeation activity
    Membrane fusogenic peptides have attracted increasing attention because of their unique biofunctions in membrane translocation and viral infection. Here, we designed GALA-related peptides with palmitoyl tails. Our study indicated that the self-assembling propensity and the secondary structure of these peptide amphiphiles greatly influenced the membrane permeability. This journal is © the Partner Organisations 2014.

    DOI: 10.1039/c4ra02901a

  • Sucrose laurate enhanced transcutaneous immunization with a solid-in-oil nanodispersion Reviewed

    Momoko Kitaoka, Kana Imamura, Yuya Hirakawa, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    MedChemComm   5 ( 1 )   20 - 24   2014.1

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    Sucrose laurate enhanced transcutaneous immunization with a solid-in-oil nanodispersion

    DOI: 10.1039/c3md00164d

  • Separation of precious metals by using undiluted ionic liquids

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Solvent Extraction Research and Development   21   89 - 94   2014.1

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    Separation of precious metals by using undiluted ionic liquids
    The ionic liquid (IL), 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][Tf2N]), was evaluated as an extractant without dilution for the separation and recovery of precious metals. Au(III) was efficiently extracted from the aqueous phase to the IL phase, and a concentrated Au(III) solution almost 8 times higher than the initial feed solutions could be produced. In contrast, Pd(II) was rarely extracted and Pt(IV) was partly extracted under the present experimental conditions. Furthermore, the effect of the IL anions on the extraction ability for the metal ions was examined, and it was found that an IL having an anion component slightly more hydrophilic compared to [Tf2N], such as 1-butyl-3-methylimidazolium hexafluorophosphate [Bmim][PF6], showed a higher extraction ability than [Bmim][Tf2N]. It was suggested that the extraction proceeded via an anion exchange mechanism and it was shown that ILs could be effective extractants for the separation of precious metals.

    DOI: 10.15261/serdj.21.89

  • One step effective separation of platinum and palladium in an acidic chloride solution by using undiluted ionic liquids

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Solvent Extraction Research and Development   21   129 - 135   2014.1

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    One step effective separation of platinum and palladium in an acidic chloride solution by using undiluted ionic liquids
    Imidazolium-based ionic liquids (ILs) with Tf2N- as anions were studied as extractants without dilution for the extractive separation of platinum and palladium in an acidic chloride solution. The effect of the alkyl chain length on the extraction performance was evaluated and, based on the performance, the IL, 1-methyl-3-octylimidazolium bis(trifluoromethylsulfonyl) imide ([Omim][Tf2N]), was selected to be studied in detail. The extraction of Pt(IV) underwent little change over the HCl concentration studied, while that of Pd(II) decreased with increasing HCl concentration. The separation of Pt(IV) and Pd(II) was highly effective, and the highest separation factor between Pt(IV) and Pd(II) reached 312 at the optimum conditions in a binary component system composed of Pt(IV) and Pd(II). The effect of the initial Pt(IV) concentration on loading capacity and extraction efficiency of Pt(IV) was also investigated.

    DOI: 10.15261/serdj.21.129

  • Development of novel extractants with amino acid structure for efficient separation of nickel and cobalt from manganese ions

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Industrial and Engineering Chemistry Research   53   812 - 818   2014.1

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    Development of novel extractants with amino acid structure for efficient separation of nickel and cobalt from manganese ions
    The solvent extraction separation of nickel and cobalt from manganese is an important issue to be resolved. Novel amic acid type extractants with the glycine or sarcosine moiety N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]glycine (D2EHAG) and N-[N,N-di(2-ethylhexyl)aminocarbonylmethyl]sarcosine (D2EHAS) were synthesized to achieve this separation. These extractants were prepared by a simple two-step reaction and were readily soluble in aliphatic organic solvents. The extraction behavior of Ni2+, Co2+, and Mn 2+ with D2EHAG and D2EHAS in n-dodecane was investigated compared with that of conventional extractants. The novel extractants extracted Ni 2+ and Co2+ preferentially with a high selectivity to Mn2+. The metal ions could be back-extracted quantitatively using 1 mol dm-3 sulfuric acid. The extraction mechanism of the three metal ions with D2EHAG and D2EHAS was investigated, and results suggest that one divalent metal ion is extracted with two extractant molecules. © 2013 American Chemical Society.

    DOI: 10.1021/ie403524a

  • Selective extraction of scandium from yttrium and lanthanides with amic acid-type extractant containing alkylamide and glycine moieties Reviewed

    Yuzo Baba, Arisa Fukami, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    RSC Advances   4 ( 92 )   50726 - 50730   2014.1

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    DOI: 10.1039/c4ra08897b

  • Conformational preference of a porphyrin rotor in confined environments Reviewed International journal

    RSC ADVANCES   4 ( 2 )   2014.1

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    DOI: 10.1039/c3ra45668d

  • Sucrose laurate-enhanced transcutaneous immunization with a solid-in-oil nanodispersion Reviewed International journal

    MEDCHEMCOMM   5 ( 1 )   2014.1

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    DOI: 10.1039/c3md00164d

  • One step effective separation of platinum and palladium in an acidic chloride solution by using undiluted ionic liquids Reviewed

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   21 ( 2 )   129 - 135   2014

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    DOI: 10.15261/serdj.21.129

  • The self-assembly and secondary structure of peptide amphiphiles determine the membrane permeation activity Reviewed

    Rie Wakabayashi, Yuko Abe, Noriho Kamiya, Masahiro Goto

    RSC Advances   4 ( 58 )   30654 - 30657   2014

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    DOI: 10.1039/c4ra02901a

  • Synergistic extraction of rare-earth metals and separation of scandium using 2-thenoyltrifluoroacetone and tri-n-octylphosphine oxide in an ionic liquid system Reviewed

    Zhigang Zhao, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   47 ( 8 )   656 - 662   2014

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    DOI: 10.1252/jcej.14we360

  • Separation of precious metals by using undiluted ionic liquids Reviewed

    Jian Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   21 ( 1 )   89 - 94   2014

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    DOI: 10.15261/serdj.21.89

  • Tailing DNA aptamers with a functional protein by two-step enzymatic reaction Reviewed International journal

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   116 ( 6 )   2013.12

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    DOI: 10.1016/j.jbiosc.2013.05.025

  • Tailing DNA aptamers with a functional protein by two-step enzymatic reaction

    Mari Takahara, Kounosuke Hayashi, Kounosuke Hayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Journal of Bioscience and Bioengineering   116   660 - 665   2013.12

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    Tailing DNA aptamers with a functional protein by two-step enzymatic reaction
    An efficient, quantitative synthetic strategy for aptamer-enzyme conjugates was developed by using a two-step enzymatic reaction. Terminal deoxynucleotidyl transferase (TdT) was used to first incorporate a Z-Gln-Gly (QG) modified nucleotide which can act as a glutamine donor for a subsequent enzymatic reaction, to the 3&#039;-OH of a DNA aptamer. Microbial transglutaminase (MTG) then catalyzed the cross-linking between the Z-QG modified aptamers and an enzyme tagged with an MTG-reactive lysine containing peptide. The use of a Z-QG modified dideoxynucleotide (Z-QG-ddUTP) or a deoxyuridine triphosphate (Z-QG-dUTP) in the TdT reaction enables the controlled introduction of a single or multiple MTG reactive residues. This leads to the preparation of enzyme-aptamer and (enzyme)n-aptamer conjugates with different detection limits of thrombin, a model analyte, in a sandwich enzyme-linked aptamer assay (ELAA). Since the combination of two enzymatic reactions yields high site-specificity and requires only short peptide substrates, the methodology should be useful for the labeling of DNA/RNA aptamers with proteins. © 2013 The Society for Biotechnology, Japan.

    DOI: 10.1016/j.jbiosc.2013.05.025

  • Needle-free immunization using a solid-in-oil nanodispersion enhanced by skin-permeable oligoarginine peptide Reviewed

    Momoko Kitaoka, Kana Imamura, Yuya Hirakawa, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   458 ( 2 )   334 - 339   2013.12

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    Needle-free immunization using a solid-in-oil nanodispersion enhanced by skin-permeable oligoarginine peptide

    DOI: 10.1016/j.ijpharm.2013.10.006

  • Enzymatic fabrication of protein-decorated gold nanoparticles by the aid of artificial peptides with gold-binding affinity

    Teppei Niide, Kojiro Shimojo, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Langmuir   29   15596 - 15605   2013.12

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    Enzymatic fabrication of protein-decorated gold nanoparticles by the aid of artificial peptides with gold-binding affinity
    Here, we report a new approach for the biofabrication of protein-immobilized gold nanoparticles (Au NPs), using oxidoreductase with gold-binding peptide-tagged recombinant proteins. The reduction of Au ions to Au0 was achieved using a natural electron-donating cofactor, nicotinamide adenine dinucleotide, which was regenerated by the glycerol dehydrogenase (GLD) enzyme. First, we selected the A3 peptide (AYSSGAPPMPPF) as a gold binding moiety. The A3 peptide was introduced to the C-terminus of fusion proteins of immunoglobulin G (IgG)-binding domains of protein G and protein A. In the presence of the recombinant protein, the GLD-catalyzed cofactor reduction resulted in the efficient in situ fabrication of Au NPs immobilized with the fusion protein. Moreover, the protein-immobilized Au NPs were shown to have IgG binding activity. Although the A3 peptide had the ability to stabilize Au NPs, the results suggested that its binding affinity for Au NPs was unexpectedly weaker than that of His-tag. A cysteine residue was thus introduced to a recombinant protein adjacent to the A3 peptide. Finally, an artificial peptide, comprising A3 sequence with the C-terminal single cysteine residue, enabled the stable display of a fusion protein while maintaining its IgG binding activity through the Au-S bond. This enzyme-assisted one-pot methodology for protein-Au NPs conjugation offers one potent route for the facile fabrication of biomolecule-decorated metal NPs. © 2013 American Chemical Society.

    DOI: 10.1021/la401327h

  • Needle-free immunization using a solid-in-oil nanodispersion enhanced by a skin-permeable oligoarginine peptide Reviewed International journal

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   458 ( 2 )   2013.12

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    DOI: 10.1016/j.ijpharm.2013.10.006

  • Enzymatic Fabrication of Protein-Decorated Gold Nanoparticles by the Aid of Artificial Peptides with Gold-Binding Affinity Reviewed International journal

    LANGMUIR   29 ( 50 )   2013.12

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    DOI: 10.1021/la401327h

  • Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate Reviewed

    Hiromu Yoshiura, Miki Tamura, Makoto Aso, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   46 ( 11 )   794 - 796   2013.11

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    DOI: 10.1252/jcej.13we009

  • Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate

    Hiromu Yoshiura, Miki Tamura, Makoto Aso, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Journal of Chemical Engineering of Japan   46   794 - 796   2013.11

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    Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate
    Ionic liquid-in-oil (IL/o) microemulsion (ME) techniques have been employed to increase the solubility of sparingly soluble drugs and enhance the extent of their topical and transdermal delivery. Methotrexate (MTX) has been used as a model drug in the current study. The size and size distributions of the ME droplets in the presence and in the absence of MTX were determined by dynamic light scattering analysis. The mean droplet diameter of the ME droplets containing 4 mg/mL of MTX was less than 20 nm, and smaller than the corresponding value observed in the absence of MTX. MTX was incorporated into IL droplets as well as other formulations and its permeation across Yucatan micropig (YMP) porcine skin evaluated. The use of IL/o ME has been shown to dramatically increase MTX administration. The results obtained in this study reveal the versatility of IL/o MEs as efficient drug delivery systems for sparingly soluble drugs. © 2013 The Society of Chemical Engineers, Japan.

    DOI: 10.1252/jcej.13we009

  • Aligning an endoglucanase Cel5A from Thermobifida fusca on a DNA scaffold: potent design of an artificial cellulosome Reviewed

    Mori Yutaro, Ozasa Shiori, Kitaoka Momoko, Noda Shuhei, Tanaka Tsutomu, Ichinose Hirofumi, Kamiya Noriho

    CHEMICAL COMMUNICATIONS   49 ( 62 )   6971 - 6973   2013.8

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    Aligning an endoglucanase Cel5A from Thermobifida fusca on a DNA scaffold: potent design of an artificial cellulosome

    DOI: 10.1039/c3cc42614a

  • Biosorption of rare earth elements by Escherichia coli

    Yukiho Hosomomi, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Journal of Chemical Engineering of Japan   46   450 - 454   2013.8

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    Biosorption of rare earth elements by Escherichia coli
    Biosorption, which takes place by passive metal-sequestering, has recently attracted attention as an alternative to conventional separation processes such as precipitation and solvent extraction. In this work, the adsorption behavior of rare earth elements (REEs) onto an Escherichia coli (E. coli) bacterial adsorbent was examined. The adsorption of REEs increased with increasing pH of the feed solution. Also, E. coli showed a higher selectivity for heavier REEs, especially for scandium. To elucidate the adsorption mechanism, the functional groups on the E. coli were chemically modified. By analyzing the adsorption behavior and FT-IR spectra of these E. coli samples before and after adsorption, it was confirmed that REEs are adsorbed at phosphate and carboxyl groups on the surface of E. coli. It is concluded that E. coli is a potential novel adsorbent for REEs. © 2013 The Society of Chemical Engineers, Japan.

    DOI: 10.1252/jcej.13we031

  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity Reviewed International journal

    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   24 ( 10 )   2013.7

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    DOI: 10.1080/09205063.2012.755600

  • Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol)

    Kousuke Moriyama, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Biochemical Engineering Journal   76   37 - 42   2013.7

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    Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol)
    Hybrid gels constructed from proteins and polymers have attracted a wide range of attention in the field of biomedicine and bioengineering. We report herein the enzymatic preparation of polymer-protein hybrid hydrogels composed of terminally bis-functionalized linear poly(ethylene glycol) (PEG) and streptavidin (SA). PEG was conjugated with tyramine to introduce terminal phenolic hydroxyl (Ph-OH) groups. A peptide tag containing a tyrosine residue (G4Y-tag) was genetically introduced at the C-terminus of SA. The Ph-OH-modified PEG and G4Y-tagged SA (SA-G4Y) were treated by horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2) to yield (PEG-Ph-OH)-(SA-G4Y) hybrid gels. Biotinylated enhanced green fluorescent protein (biotin-EGFP) was selectively captured in the obtained hybrid gels, indicating that SA-G4Y retained its biological function. The amount of biotin-EGFP immobilized in the hybrid gels depended on the concentration of SA-G4Y. In addition, biotinylated bacterial alkaline phosphatase (biotin-BAP) was immobilized in the hybrid gel. The immobilized biotin-BAP exhibited more than 95% of the initial activity after 5 rounds of recycling. The results suggest the facile functionalization of the hybrid gel with a variety of biotinylated functional molecules. © 2013 Elsevier B.V.

    DOI: 10.1016/j.bej.2013.04.007

  • Aligning an endoglucanase Cel5A from Thermobifida fusca on a DNA scaffold Potent design of an artificial cellulosome Reviewed

    Yutaro Mori, Shiori Ozasa, Momoko Kitaoka, Shuhei Noda, Tsutomu Tanaka, Hirofumi Ichinose, Noriho Kamiya

    Chemical Communications   49 ( 62 )   6971 - 6973   2013.7

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    DOI: 10.1039/c3cc42614a

  • Enzymatic preparation of streptavidin-immobilized hydrogel using a phenolated linear poly(ethylene glycol) Reviewed International journal

    BIOCHEMICAL ENGINEERING JOURNAL   76   2013.7

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    DOI: 10.1016/j.bej.2013.04.007

  • Peracetic acid-ionic liquid pretreatment to enhance enzymatic saccharification of lignocellulosic biomass Reviewed International journal

    BIORESOURCE TECHNOLOGY   138   2013.6

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    DOI: 10.1016/j.biortech.2013.03.147

  • Selective extraction and recovery of rare earth metals from phosphor powders in waste fluorescent lamps using an ionic liquid system

    Fan Yang, Fukiko Kubota, Yuzo Baba, Noriho Kamiya, Noriho Kamiya, Masahiro Goto, Masahiro Goto

    Journal of Hazardous Materials   254-255   79 - 88   2013.6

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    Selective extraction and recovery of rare earth metals from phosphor powders in waste fluorescent lamps using an ionic liquid system
    The recycling of rare earth metals from phosphor powders in waste fluorescent lamps by solvent extraction using ionic liquids was studied. Acid leaching of rare earth metals from the waste phosphor powder was examined first. Yttrium (Y) and europium (Eu) dissolved readily in the acid solution; however, the leaching of other rare earth metals required substantial energy input. Ionization of target rare earth metals from the waste phosphor powders into the leach solution was critical for their successful recovery. As a high temperature was required for the complete leaching of all rare earth metals, ionic liquids, for which vapor pressure is negligible, were used as an alternative extracting phase to the conventional organic diluent. An extractant, N, N-dioctyldiglycol amic acid (DODGAA), which was recently developed, showed a high affinity for rare earth metal ions in liquid-liquid extraction although a conventional commercial phosphonic extractant did not. An effective recovery of the rare earth metals, Y, Eu, La and Ce, from the metal impurities, Fe, Al and Zn, was achieved from the acidic leach solution of phosphor powders using an ionic liquid containing DODGAA as novel extractant system. © 2013 Elsevier B.V.

    DOI: 10.1016/j.jhazmat.2013.03.026

  • Preparation and evaluation of cellulose-dissolving magnetic ionic liquid Reviewed

    Jin Muraoka, Noriho Kamiya, Yuji Ito

    Journal of Molecular Liquids   182   76 - 78   2013.6

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    DOI: 10.1016/j.molliq.2013.03.012

  • Peracetic acid-ionic liquid pretreatment to enhance enzymatic saccharification of lignocellulosic biomass

    Uju, Kojiro Abe, Nobuyuki Uemura, Toyoji Oshima, Masahiro Goto, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   138   87 - 94   2013.6

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    DOI: 10.1016/j.biortech.2013.03.147

  • Preparation and evaluation of cellulose-dissolving magnetic ionic liquid Reviewed International journal

    JOURNAL OF MOLECULAR LIQUIDS   182   2013.6

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    DOI: 10.1016/j.molliq.2013.03.012

  • Selective extraction and recovery of rare earth metals from phosphor powders in waste fluorescent lamps using an ionic liquid system Reviewed International journal

    JOURNAL OF HAZARDOUS MATERIALS   254   2013.6

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    DOI: 10.1016/j.jhazmat.2013.03.026

  • Low melting point pyridinium ionic liquid pretreatment for enhancing enzymatic saccharification of cellulosic biomass Reviewed International journal

    BIORESOURCE TECHNOLOGY   135   2013.5

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    DOI: 10.1016/j.biortech.2012.06.096

  • 希土類金属の新規吸着剤としての大腸菌の応用

    細樅 侑貴穂, 馬場 雄三, 久保田 富生子, 神谷 典穂, 後藤 雅宏

    希土類 = Rare earths   ( 62 )   176 - 177   2013.5

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  • Low melting point pyridinium ionic liquid pretreatment for enhancing enzymatic saccharification of cellulosic biomass

    Uju, Aya Nakamoto, Yasuhiro Shoda, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Chiaki Ogino, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   135   103 - 108   2013.5

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    DOI: 10.1016/j.biortech.2012.06.096

  • 薬物漏洩を制御した多層エマルションの調製と経皮吸収促進効果 Reviewed

    安部祐子, 田原義朗, 若林里衣, 神谷典穂, 後藤雅宏

    膜   38 ( 2 )   92 - 96   2013.3

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    DOI: 10.5360/membrane.38.92

  • Split Spy0128 as a Potent Scaffold for Protein Cross-Linking and Immobilization Reviewed International journal

    Hiroki Abe, Rie Wakabayashi, Hiroaki Yonemura, Sunao Yamada, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   24 ( 2 )   2013.2

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    DOI: 10.1021/bc300606b

  • 経皮薬物投与を目指したイオン液体製剤の開発 (特集 イオン液体応用技術の新展開)

    麻生 慎, 神谷 典穂, 後藤 雅宏

    化學工業   64 ( 2 )   116 - 121   2013.2

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  • Split Spy0128 as a potent scaffold for protein cross-linking and immobilization

    Hiroki Abe, Rie Wakabayashi, Hiroaki Yonemura, Hiroaki Yonemura, Sunao Yamada, Sunao Yamada, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Bioconjugate Chemistry   24   242 - 250   2013.2

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    Split Spy0128 as a potent scaffold for protein cross-linking and immobilization
    Site-specific cross-linking techniques between proteins and additional functional groups have become increasingly important for expanding the utility of proteins in biochemistry and biotechnology. In order to explore powerful techniques for practical bioconjugation applications, we have validated a technique mediated by a unique property of Streptcoccus pyogenes pilin subunit Spy0128, an autocatalytic intramolecular isopeptide formation in Spy0128. Recently, it has been revealed that Spy0128 can be split into two fragments (split-Spy0128 (residues 18-299 of Spy0128) and isopeptag (residues 293-308 of Spy0128)) that were capable of forming an intermolecular covalent complex. We focused on this unique reconstitution property and first studied the bioconjugation of blue and green fluorescent proteins, enabling the direct monitoring of cross-linking reactions by Förster resonance energy transfer (FRET). A fluorescence lifetime study shows that spatial control of two proteins on the Spy0128 scaffold is possible when one protein is fused to the N-terminus of split-Spy0128 and another one is tethered at the N- or C-terminus of the isopeptag. Furthermore, we demonstrated site-specific protein immobilization mediated by the reconstitution of split-Spy0128 and isopeptag. In this case, a split-Spy0128 mutant with a free N-terminal Cys residue was first immobilized onto beads chemically modified with a maleimide group through a Michael addition process. Then, an isopeptagged protein was successfully immobilized onto the split-Spy0128-immobilized beads. These results suggest that Spy0128 is a potent proteinaceous scaffold available for bioconjugation both in solution and at a solid surface. © 2013 American Chemical Society.

    DOI: 10.1021/bc300606b

  • Protein supramolecular complex formation by site-specific avidin-biotin interactions

    Yutaro Mori, Rie Wakabayashi, Masahiro Goto, Masahiro Goto, Noriho Kamiya, Noriho Kamiya

    Organic and Biomolecular Chemistry   11 ( 6 )   914 - 922   2013.2

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    Protein supramolecular complex formation by site-specific avidin-biotin interactions
    The precise accumulation of protein functions on a nanoscale to fabricate advanced biomaterials has become possible by a bottom-up approach based on molecular self-assembly. The avidin-biotin interaction is widely employed in the design of functional protein self-assemblies. Herein we assessed how the spatial arrangement of the avidin-biotin interaction between protein building blocks affects the formation of a protein supramolecular complex (PSC). The enzymatic site-specific internal labeling of a symmetric protein scaffold, bacterial alkaline phosphatase (AP), with specifically designed biotinylation substrates revealed that the precise positioning of the biotinylation sites on AP and the linker flexibility of the substrate are critical factors for the growth of PSCs in the presence of streptavidin (SA). A potential diagnostic application of the PSCs comprised of AP and SA was demonstrated in an enzyme-linked immunosorbent assay. © 2013 The Royal Society of Chemistry.

    DOI: 10.1039/c2ob26625c

  • Protein supramolecular complex formation by site-specific avidin-biotin interactions Reviewed

    Yutaro Mori, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya

    Organic and Biomolecular Chemistry   11 ( 6 )   914 - 922   2013.2

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    DOI: 10.1039/c2ob26625c

  • Enzymatic synthesis of Z-aspartame in liquefied amino acid substrates Reviewed International journal

    Shinya Furukawa, Kazuhiro Hasegawa, Ichino Fuke, Kkoji Kittaka, Terumitsu Nakakoba, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   70   2013.1

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    DOI: 10.1016/j.bej.2012.10.002

  • S/O-nanodispersion electrospun nanofiber mesh effective for sustained release of healthy plasmid DNA with the structuraland functional integrity Reviewed International journal

    Tatsuya Okuda, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Satoru Kidoaki

    Journal of Biomaterials Science, Polymer Edition   24 ( 10 )   1277 - 1290   2013.1

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    S/O-nanodispersion electrospun nanofiber mesh effective for sustained release of healthy plasmid DNA with the structuraland functional integrity
    Localized and sustained delivery of the therapeutic genes using a solid carrier matrix is a potential approach to develop highly curative treatments. Electrospun nanofiber mesh of biodegradable polymer has been applied extensively as a carrier for localized and sustained delivery of drugs, proteins, and DNA, but it remains difficult to release sufficient amounts of DNA while maintaining structural and functional integrity. To realize the stable sustained release of the healthy plasmid DNA (pDNA) from electrospun fiber mesh, a novel method was examined for loading pDNA into the fibers based on solid-in-oil (S/O) nanodispersion of pDNA in organic solvent for electrospinning polymer solution: S/O nanodispersion electrospinning. A prepared pDNA-loaded fiber mesh made of biodegradable polymer showed sustained release of pDNA without burst release. From luciferase activity-based in vitro transcription-translation assay, pDNA released from meshes of the S/O nanodispersion retained about 60% luciferase activity of control pDNA, whereas pDNA released from the meshes of simple mixing showed only about 5% activity, indicating that S/O nanodispersion electrospinning is effective for loading pDNA into electrospun fiber meshes while maintaining their healthy functions. Effectiveness of S/O nanodispersion electrospinning was verified for fabricating a sustained release carrier matrix for high molecular weight bioactives, including therapeutic genes.

    DOI: 10.1080/09205063.2012.755600

  • Enzymatic synthesis of Z-aspartame in liquefied amino acid substrates

    Shinya Furukawa, Kazuhiro Hasegawa, Ichiro Fuke, Koji Kittaka, Terumitsu Nakakoba, Masahiro Goto, Noriho Kamiya

    Biochemical Engineering Journal   70   84 - 87   2013.1

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    DOI: 10.1016/j.bej.2012.10.002

  • A comparative study of ionic liquids and a conventional organic solvent on the extraction of rare-earth ions with TOPO Reviewed

    Fan Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   20   225 - 232   2013

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    DOI: 10.15261/serdj.20.225

  • Extraction of rare-earth ions with an 8-hydroxyquinoline derivative in an ionic liquid Reviewed

    Fan Yang, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   20   123 - 129   2013

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    DOI: 10.15261/serdj.20.123

  • Biosorption of rare earth elements by Escherichia coli Reviewed

    Yukiho Hosomomi, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   46 ( 7 )   450 - 454   2013

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    DOI: 10.1252/jcej.13we031

  • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides Reviewed International journal

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Masahiro Goto

    MEDCHEMCOMM   3 ( 12 )   2012.12

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    DOI: 10.1039/c2md20059g

  • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Masahiro Goto

    MEDCHEMCOMM   3 ( 12 )   1496 - 1499   2012.12

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    DOI: 10.1039/c2md20059g

  • Solid-in-oil dispersion A novel core technology for drug delivery systems Reviewed

    Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   438 ( 1-2 )   249 - 257   2012.11

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    DOI: 10.1016/j.ijpharm.2012.09.007

  • Solid-in-oil dispersion: A novel core technology for drug delivery systems

    Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   438 ( 1-2 )   249 - 257   2012.11

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    DOI: 10.1016/j.ijpharm.2012.09.007

  • Activation of Pyrococcus furiosus alkaline phosphatase by divalent metal ions

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOTECHNOLOGY LETTERS   34 ( 11 )   2055 - 2060   2012.11

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    DOI: 10.1007/s10529-012-0998-0

  • Activation of Pyrococcus furiosus alkaline phosphatase by divalent metal ions Reviewed

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Biotechnology letters   34 ( 11 )   2055 - 2060   2012.10

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    DOI: 10.1007/s10529-012-0998-0

  • Lipase incorporated ionic liquid polymers as active, stable and reusable biocatalysts Reviewed

    Muhammad Moniruzzaman, Keishirou Ino, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   10 ( 38 )   7707 - 7713   2012.10

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    DOI: 10.1039/c2ob25529d

  • Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier Reviewed International journal

    Fan Yang, Noriho Kamiya, Masahiro Goto

    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS   82 ( 1 )   2012.9

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    DOI: 10.1016/j.ejpb.2012.05.016

  • Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier

    Fan Yang, Noriho Kamiya, Masahiro Goto

    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS   82 ( 1 )   158 - 163   2012.9

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    DOI: 10.1016/j.ejpb.2012.05.016

  • Control of a Tyrosyl Radical Mediated Protein Cross-Linking Reaction by Electrostatic Interaction Reviewed International journal

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   23 ( 8 )   2012.8

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    DOI: 10.1021/bc300137s

  • Control of a Tyrosyl Radical Mediated Protein Cross-Linking Reaction by Electrostatic Interaction

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   23 ( 8 )   1600 - 1609   2012.8

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    DOI: 10.1021/bc300137s

  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells

    Yoshiro Tahara, Takeshi Kaneko, Riki Toita, Chiharu Yoshiyama, Takuya Kitaoka, Takuro Niidome, Yoshiki Katayama, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CONTROLLED RELEASE   161 ( 3 )   713 - 721   2012.8

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    DOI: 10.1016/j.jconrel.2012.05.001

  • Activation of Pyrococcus furiosus alkaline phosphatase by divalent metal ions Reviewed International journal

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Biotechnol. Lett.   34   2012.8

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  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells Reviewed International journal

    Yoshiro Tahara, Takeshi Kaneko, Riki Toita, Chiharu Yoshiyama, Takuya Kitaoka, Takuro Niidome, Yoshiki Katayama, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CONTROLLED RELEASE   161 ( 3 )   2012.8

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    DOI: 10.1016/j.jconrel.2012.05.001

  • Lipase incorporated ionic liquid polymers as active, stable and reusable biocatalysts Reviewed International journal

    Muhammad Moniruzzaman, Keishirou Ino, Noriho Kamiya, Masahiro Goto

    Org. Biomol. Chem.   14   2012.8

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  • Transglutaminase-Mediated in Situ Hybridization (TransISH) System: A New Methodology for Simplified mRNA Detection Reviewed International journal

    Noriho Kamiya, Momoko Kitaoka, Kounosuke Hayashi, Yoshiyuki HIraishi, Koji Nakano, Katsuyuki Miyawaki, Sumihare Noji, Masahiro Goto

    ANALYTICAL CHEMISTRY   84 ( 14 )   2012.7

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    DOI: 10.1021/ac2034198

  • Transglutaminase-Mediated in Situ Hybridization (TransISH) System: A New Methodology for Simplified mRNA Detection

    Momoko Kitaoka, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Hisao Yoshinaga, Koji Nakano, Katsuyuki Miyawaki, Sumihare Noji, Masahiro Goto, Noriho Kamiya

    ANALYTICAL CHEMISTRY   84 ( 14 )   5885 - 5891   2012.7

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    DOI: 10.1021/ac2034198

  • Facile, rapid and efficient biofabrication of gold nanoparticles decorated with functional proteins Reviewed

    Kojiro Shimojo, Teppei Niide, Tomitsugu Taguchi, Hirochika Naganawa, Noriho Kamiya, Masahiro Goto

    Analyst   137 ( 10 )   2300 - 2303   2012.5

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    DOI: 10.1039/c2an35172b

  • Programmable protein-protein conjugation via DNA-based self-assembly Reviewed

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Hisao Yoshinaga, Koji Nakano, Noriho Kamiya, Masahiro Goto

    Chemical Communications   48 ( 50 )   6226 - 6228   2012.5

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    DOI: 10.1039/c2cc30618b

  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on His-tag chemistry Reviewed International journal

    J.Shimada, T. Maruyama, M. Kitaoka, N. Kamiya, M. Goto

    Anal. Biochem.   421   2012.2

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  • チロシルラジカルの電荷指向型カップリング反応によるタンパク質架橋

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会年会研究発表講演要旨集(CD-ROM)   77th   ROMBUNNO.B214   2012.2

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  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on histidine-tag chemistry

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    ANALYTICAL BIOCHEMISTRY   421 ( 2 )   541 - 546   2012.2

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    DOI: 10.1016/j.ab.2011.11.028

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery

    Eiichi Toorisaka, Kikumi Watanabe, Hiroshige Ono, Makoto Hirata, Noriho Kamiya, Masahiro Goto

    ACTA BIOMATERIALIA   8 ( 2 )   653 - 658   2012.2

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    DOI: 10.1016/j.actbio.2011.09.023

  • Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on histidine-tag chemistry Reviewed

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   421 ( 2 )   541 - 546   2012.2

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    DOI: 10.1016/j.ab.2011.11.028

  • Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery Reviewed

    Eiichi Toorisaka, Kikumi Watanabe, Hiroshige Ono, Makoto Hirata, Noriho Kamiya, Masahiro Goto

    Acta Biomaterialia   8 ( 2 )   653 - 658   2012.2

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    DOI: 10.1016/j.actbio.2011.09.023

  • チロシンタグ導入タンパク質/フェノール性水酸基含有ヒドロゲル融合基材の開発

    境慎司, 足立辰弥, 南畑孝介, 後藤雅宏, 神谷典穂, 川上幸衛, 田谷正仁

    化学工学会年会研究発表講演要旨集(CD-ROM)   77th   ROMBUNNO.A113   2012.2

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  • Short time ionic liquids pretreatment on lignocellulosic biomass to enhance enzymatic saccharification Reviewed

    Uju, Yasuhiro Shoda, Aya Nakamoto, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Kazunori Nakashima, Chiaki Ogino, Noriho Kamiya

    Bioresource Technology   103 ( 1 )   446 - 452   2012.1

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    DOI: 10.1016/j.biortech.2011.10.003

  • Short time ionic liquids pretreatment on lignocellulosic biomass to enhance enzymatic saccharification

    Uju, Yasuhiro Shoda, Aya Nakamoto, Masahiro Goto, Wataru Tokuhara, Yoshiyuki Noritake, Satoshi Katahira, Nobuhiro Ishida, Kazunori Nakashima, Chiaki Ogino, Noriho Kamiya

    BIORESOURCE TECHNOLOGY   103 ( 1 )   446 - 452   2012.1

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    DOI: 10.1016/j.biortech.2011.10.003

  • Extraction and separation of rare earth metal ions with DODGAA in ionic liquids Reviewed

    Fan Yang, Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   19   69 - 76   2012

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    DOI: 10.15261/serdj.19.69

  • Protein lipidation catalyzed by microbial transglutaminase Reviewed

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Chemistry - A European Journal   17 ( 50 )   14004 - 14008   2011.12

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    DOI: 10.1002/chem.201102121

  • Protein Lipidation Catalyzed by Microbial Transglutaminase

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    CHEMISTRY-A EUROPEAN JOURNAL   17 ( 50 )   14004 - 14008   2011.12

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    DOI: 10.1002/chem.201102121

  • Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation Reviewed

    Hongyu Piao, Noriho Kamiya, Fude Cui, Masahiro Goto

    International Journal of Pharmaceutics   420 ( 1 )   156 - 160   2011.11

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    DOI: 10.1016/j.ijpharm.2011.08.025

  • Protein Heteroconjugation by the Peroxidase-Catalyzed Tyrosine Coupling Reaction

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   22 ( 11 )   2332 - 2338   2011.11

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    DOI: 10.1021/bc200420v

  • Preparation of a solid-in-oil nanosuspension containing L-ascorbic acid as a novel long-term stable topical formulation

    Hongyu Piao, Noriho Kamiya, Fude Cui, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   420 ( 1 )   156 - 160   2011.11

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    DOI: 10.1016/j.ijpharm.2011.08.025

  • Recent advances in extraction and separation of rare-earth metals using ionic liquids Reviewed

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   44 ( 10 SPEC. ISSUE )   679 - 685   2011.11

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    DOI: 10.1252/jcej.10we279

  • Protein heteroconjugation by the peroxidase-catalyzed tyrosine coupling reaction Reviewed

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   22 ( 11 )   2332 - 2338   2011.11

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    DOI: 10.1021/bc200420v

  • Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation Reviewed International journal

    H. Piao, N. Kamiya, F. Cui, M. Goto

    Int. J. Pharm.   420   2011.10

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  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium Reviewed International journal

    J.Shimada, T. Maruyama, M. Kitaoka, N. Kamiya, M. Goto

    Anal. Biochem.   414   2011.9

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  • Protein assemblies by site-specific avidin-biotin interactions Reviewed

    Yutaro Mori, Kosuke Minamihata, Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Organic and Biomolecular Chemistry   9 ( 16 )   5641 - 5644   2011.8

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    DOI: 10.1039/c1ob05428g

  • ストレプトアビジンー酵素ハイブリッドの新規調製法の開発

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)   43rd   ROMBUNNO.P1O054   2011.8

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  • Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells Reviewed

    Teppei Niide, Masahiro Goto, Noriho Kamiya

    Chemical Communications   47 ( 26 )   7350 - 7352   2011.7

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    DOI: 10.1039/c1cc12302e

  • Transglutaminase-mediated internal protein labeling with a designed peptide loop

    Yutaro Mori, Masahiro Goto, Noriho Kamiya

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   410 ( 4 )   829 - 833   2011.7

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    DOI: 10.1016/j.bbrc.2011.06.073

  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium

    Josui Shimoda, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    ANALYTICAL BIOCHEMISTRY   414 ( 1 )   103 - 108   2011.7

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    DOI: 10.1016/j.ab.2011.02.035

  • Transglutaminase-mediated internal protein labeling with a designed peptide loop Reviewed

    Yutaro Mori, Masahiro Goto, Noriho Kamiya

    Biochemical and Biophysical Research Communications   410 ( 4 )   829 - 833   2011.7

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    DOI: 10.1016/j.bbrc.2011.06.073

  • DNA-enzyme conjugate with a weak inhibitor that can specifically detect thrombin in a homogeneous medium Reviewed

    Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   414 ( 1 )   103 - 108   2011.7

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    DOI: 10.1016/j.ab.2011.02.035

  • Immobilization of alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase Reviewed

    Kousuke Moriyama, Kyunga Sung, Masahiro Goto, Noriho Kamiya

    Journal of Bioscience and Bioengineering   111 ( 6 )   650 - 653   2011.6

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    DOI: 10.1016/j.jbiosc.2011.02.002

  • Immobilization of alkaline phosphatase on magnetic particles by site-specific and covalent cross-linking catalyzed by microbial transglutaminase

    Kousuke Moriyama, Kyunga Sung, Masahiro Goto, Noriho Kamiya

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   111 ( 6 )   650 - 653   2011.6

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    DOI: 10.1016/j.jbiosc.2011.02.002

  • Transglutaminase-mediated synthesis of a DNA-(Enzyme)n probe for highly sensitive DNA detection Reviewed

    Momoko Kitaoka, Yukito Tsuruda, Yukari Tanaka, Masahiro Goto, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    Chemistry - A European Journal   17 ( 19 )   5387 - 5392   2011.5

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    DOI: 10.1002/chem.201003744

  • Transglutaminase-Mediated Synthesis of a DNA-(Enzyme)(n) Probe for Highly Sensitive DNA Detection

    Momoko Kitaoka, Yukito Tsuruda, Yukari Tanaka, Masahiro Goto, Masayuki Mitsumori, Kounosuke Hayashi, Yoshiyuki Hiraishi, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    CHEMISTRY-A EUROPEAN JOURNAL   17 ( 19 )   5387 - 5392   2011.5

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    DOI: 10.1002/chem.201003744

  • Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state Reviewed International journal

    M. Sakono, K. Motomura, T. Maruyama, N. Kamiya, M. Goto

    Biochem. Biophys. Res. Commun.   404   2011.4

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  • Conjugation of enzymes on RNA probes through Cu(I) catalyzed alkyne-azide cycloaddition

    Momoko Kitaoka, Yukari Tanaka, Yutaka Tada, Masahiro Goto, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    BIOTECHNOLOGY JOURNAL   6 ( 4 )   470 - 476   2011.4

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    DOI: 10.1002/biot.201000249

  • Conjugation of enzymes on RNA probes through Cu(I) catalyzed alkyne-azide cycloaddition Reviewed

    Momoko Kitaoka, Yukari Tanaka, Yutaka Tada, Masahiro Goto, Katsuyuki Miyawaki, Sumihare Noji, Noriho Kamiya

    Biotechnology Journal   6 ( 4 )   470 - 476   2011.4

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    DOI: 10.1002/biot.201000249

  • A solid-in-oil dispersion of gold nanorods can enhance trandermal protein delivery and skin vaccination Reviewed International journal

    D. Pissuwan, K. Nose, R. Kurihara, K. Kaneko, Y. Tahara, N. Kamiya, M. Goto, Y. Katayama, T. Niidome

    small   7   2011.2

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  • チロシン酸化反応を用いた異種タンパク質架橋体の酵素合成

    南畑孝介, 後藤雅宏, 神谷典穂

    化学工学会年会研究発表講演要旨集(CD-ROM)   76th   ROMBUNNO.A318   2011.2

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  • New strategy to enhance catalytic performance of Escherichia coli whole cell biocatalysts harboring P450cam mutants Reviewed International journal

    T. Mouri, N. Kamiya,* M. Goto

    Biochem. Eng. J.   53   2011.1

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  • Site-Specific Protein Cross-Linking by Peroxidase-Catalyzed Activation of a Tyrosine-Containing Peptide Tag

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    BIOCONJUGATE CHEMISTRY   22 ( 1 )   74 - 81   2011.1

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    DOI: 10.1021/bc1003982

  • New strategy to enhance catalytic performance of Escherichia coli whole cell biocatalysts harboring P450cam mutants

    Tsuyoshi Mouri, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   53 ( 2 )   229 - 233   2011.1

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    DOI: 10.1016/j.bej.2010.09.016

  • Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state

    Masafumi Sakono, Konomi Motomura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   404 ( 1 )   494 - 497   2011.1

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    DOI: 10.1016/j.bbrc.2010.12.009

  • A Solid-in-Oil Dispersion of Gold Nanorods Can Enhance Transdermal Protein Delivery and Skin Vaccination

    Dakrong Pissuwan, Keisuke Nose, Ryohsuke Kurihara, Kenji Kaneko, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

    SMALL   7 ( 2 )   215 - 220   2011.1

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    DOI: 10.1002/smll.201001394

  • Site-specific protein cross-linking by peroxidase-catalyzed activation of a tyrosine-containing peptide tag Reviewed

    Kosuke Minamihata, Masahiro Goto, Noriho Kamiya

    Bioconjugate Chemistry   22 ( 1 )   74 - 81   2011.1

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    DOI: 10.1021/bc1003982

  • New strategy to enhance catalytic performance of Escherichia coli whole cell biocatalysts harboring P450cam mutants Reviewed

    Tsuyoshi Mouri, Noriho Kamiya, Masahiro Goto

    Biochemical Engineering Journal   53 ( 2 )   229 - 233   2011.1

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    DOI: 10.1016/j.bej.2010.09.016

  • New fluorescent substrates of microbial transglutaminase and its application to peptide tag-directed covalent protein labeling

    Noriho Kamiya, Hiroki Abe

    Methods in Molecular Biology   81 - 94   2011.1

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    DOI: 10.1007/978-1-61779-151-2_7

  • Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state Reviewed

    Masafumi Sakono, Konomi Motomura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Biochemical and Biophysical Research Communications   404 ( 1 )   494 - 497   2011.1

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    DOI: 10.1016/j.bbrc.2010.12.009

  • A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination Reviewed

    Dakrong Pissuwan, Keisuke Nose, Ryohsuke Kurihara, Kenji Kaneko, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

    Small   7 ( 2 )   215 - 220   2011.1

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    DOI: 10.1002/smll.201001394

  • Application of ionic liquids to extraction separation of rare earth metals with an effective diglycol amic acid extractant Reviewed

    Fukiko Kubota, Yousuke Shimobori, Yuzo Baba, Yusuke Koyanagi, Kojiro Shimojo, Noiho Kamiya, Masahiro Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   44 ( 5 )   307 - 312   2011

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    DOI: 10.1252/jcej.11we005

  • Selective recovery of dysprosium and neodymium ions by a supported liquid membrane based on ionic liquids Reviewed

    Yuzo Baba, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   18   193 - 198   2011

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    DOI: 10.15261/serdj.18.193

  • Development of ionic liquid-based consolidated bioprocessing (I-CBP) for bioethanol production

    Nobuiro Ishida, Satoshi Katahira, Wataru Tokuhara, Yoshiyuki Noritake, Noriho Kamiya, Kazunori Nakashima, Chiaki Ogino, Akihiko Kondo

    Sustainable Engineering Forum: Core Programming Topic at the 2011 AIChE Annual Meeting Sustainable Engineering Forum Core Programming Topic at the 2011 AIChE Annual Meeting   2011

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  • Ionic liquid based microemulsion with pharmaceutically accepted components Formulation and potential applications Reviewed

    Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    Journal of Colloid And Interface Science   352 ( 1 )   136 - 142   2010.12

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    DOI: 10.1016/j.jcis.2010.08.035

  • Ionic liquid based microemulsion with pharmaceutically accepted components: Formulation and potential applications

    Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    JOURNAL OF COLLOID AND INTERFACE SCIENCE   352 ( 1 )   136 - 142   2010.12

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    DOI: 10.1016/j.jcis.2010.08.035

  • Transcutaneous immunization by a solid-in-oil nanodispersion Reviewed

    Yoshiro Tahara, Kenichi Namatsu, Noriho Kamiya, Masayori Hagimori, Seitaro Kamiya, Masayuki Arakawa, Masahiro Goto

    Chemical Communications   46 ( 48 )   9200 - 9202   2010.12

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    DOI: 10.1039/c0cc03600e

  • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug Characterization and cytotoxicity evaluation Reviewed

    Muhammad Moniruzzaman, Miki Tamura, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   400 ( 1-2 )   243 - 250   2010.11

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    DOI: 10.1016/j.ijpharm.2010.08.034

  • 新規カチオン性ダブルコーティング型キャリアによる遺伝子デリバリー

    田原義朗, 金子丈志, 戸井田力, 神谷典穂, 新留琢郎, 片山佳樹, 後藤雅宏

    日本バイオマテリアル学会大会予稿集   32nd   192   2010.11

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  • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation

    Muhammad Moniruzzaman, Miki Tamura, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   400 ( 1-2 )   243 - 250   2010.11

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    DOI: 10.1016/j.ijpharm.2010.08.034

  • Enzymatic single-step preparation of multifunctional proteins Reviewed

    Hiroki Abe, Masahiro Goto, Noriho Kamiya

    Chemical Communications   46 ( 38 )   7160 - 7162   2010.10

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    DOI: 10.1039/c0cc02133d

  • 部位特異的タンパク質修飾のための高反応性トランスグルタミナーゼ基質ペプチド配列の探索

    尾上佳大, 神谷典穂, 南畑孝介, 安倍弘喜, 後藤雅宏

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)   42nd   ROMBUNNO.L1P60   2010.8

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  • Selective separation of precious metals using biomass materials Reviewed

    Yukiko Shimada, Teppei Niide, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    kagaku kogaku ronbunshu   36 ( 4 )   255 - 258   2010.7

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    DOI: 10.1252/kakoronbunshu.36.255

  • ファージディスプレイ法を用いた部位特異的タンパク質修飾のためのペプチドタグの探索

    尾上佳大, 神谷典穂, 南畑孝介, 安倍弘喜, 毛利剛, 後藤雅宏, 人見清隆

    化学関連支部合同九州大会・外国人研究者交流国際シンポジウム講演予稿集   47th   255   2010.7

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  • Transcutaneous immunization by a solid-in-oil nanodispersion Reviewed International journal

    Yoshiro TAHARA, Kenichi NAMATSU, Noriho KAMIYA, Masayori HAGIMORI, Shinji KAMIYA, Masayuki ARAKAWA, Masahiro GOTO

    Chem. Commun.   46   2010.6

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  • Activation and stabilization of enzymes in ionic liquids Reviewed

    Muhammad Moniruzzaman, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   8 ( 13 )   2887 - 2899   2010.6

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    DOI: 10.1039/b926130c

  • Functional glass surface displaying a glutamyl donor substrate for transglutaminase-mediated protein immobilization Reviewed International journal

    K. Sung, N. Kamiya,* N. Kawata, S. Kamiya and M. Goto

    Biotechnol. J.   46   2010.6

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  • Enzymatic single-step preparation of multifunctional proteins Reviewed International journal

    Hiroki Abe, Masahiro GOTO, Noriho KAMIYA

    Chem. Commun.   46   2010.5

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  • 独自のエマルション化技術を利用した新規ダブルコーティング型キャリアの開発

    田原義朗, 金子丈志, 戸井田力, 神谷典穂, 新留琢郎, 片山佳樹, 後藤雅宏

    25 ( 3 )   302   2010.5

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  • 新規ダブルコーティング型キャリアの開発と非ウイルス性遺伝子デリバリーへの応用

    田原義朗, 金子丈志, 戸井田力, 神谷典穂, 新留琢郎, 片山佳樹, 後藤雅宏

    25 ( 3 )   334   2010.5

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  • Functional glass surface displaying a glutamyl donor substrate for transglutaminase-mediated protein immobilization

    Kyunga Sung, Noriho Kamiya, Noriyuki Kawata, Shinji Kamiya, Masahiro Goto

    BIOTECHNOLOGY JOURNAL   5 ( 5 )   456 - 462   2010.5

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    DOI: 10.1002/biot.200900302

  • Artificial Self-Sufficient P450 in Reversed Micelles

    Hidehiko Hirakawa, Noriho Kamiya, Yutaka Kawarabayasi, Teruyuki Nagamune

    MOLECULES   15 ( 5 )   2935 - 2948   2010.5

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    DOI: 10.3390/molecules15052935

  • Functional glass surface displaying a glutamyl donor substrate for transglutaminase-mediated protein immobilization Reviewed

    Kyunga Sung, Noriho Kamiya, Noriyuki Kawata, Shinji Kamiya, Masahiro Goto

    Biotechnology Journal   5 ( 5 )   456 - 462   2010.5

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    DOI: 10.1002/biot.200900302

  • Artificial self-sufficient P450 in reversed micelles Reviewed

    Hidehiko Hirakawa, Noriho Kamiya, Yutaka Kawarabayasi, Teruyuki Nagamune

    Molecules   15 ( 5 )   2935 - 2948   2010.5

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    DOI: 10.3390/molecules15052935

  • Uphill transport of rare-earth metals through a highly stable supported liquid membrane based on an ionic liquid Reviewed

    Fukiko Kubota, Yousuke Shimobori, Yusuke Koyanagi, Kojiro Shimojo, Noriho Kamiya, Masahiro Goto

    analytical sciences   26 ( 3 )   289 - 290   2010.3

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    DOI: 10.2116/analsci.26.289

  • Uphill Transport of Rare-Earth Metals through a Highly Stable Supported Liquid Membrane Based on an Ionic Liquid

    Fukiko Kubota, Yousuke Shimobori, Yusuke Koyanagi, Kojiro Shimojo, Noriho Kamiya, Masahiro Goto

    ANALYTICAL SCIENCES   26 ( 3 )   289 - 290   2010.3

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    DOI: 10.2116/analsci.26.289

  • Recent advances of enzymatic reactions in ionic liquids Reviewed

    Muhammad Moniruzzaman, Kazunori Nakashima, Noriho Kamiya, Masahiro Goto

    Biochemical Engineering Journal   48 ( 3 )   295 - 314   2010.2

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    DOI: 10.1016/j.bej.2009.10.002

  • 新たなタンパク質複合化技術を用いた固定化酵素調製法

    南畑孝介, 神谷典穂, 後藤雅宏

    化学工学会年会研究発表講演要旨集(CD-ROM)   75th   ROMBUNNO.D106   2010.2

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  • Recent advances of enzymatic reactions in ionic liquids

    Muhammad Moniruzzaman, Kazunori Nakashima, Noriho Kamiya, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   48 ( 3 )   295 - 314   2010.2

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    DOI: 10.1016/j.bej.2009.10.002

  • Ionic liquid-assisted transdermal delivery of sparingly soluble drugs Reviewed International journal

    M. Moniruzzaman, Y. Tahara, M. Tamura, N. Kamiya, M. Goto

    Chem. Commun.   46   2010.1

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  • Quaternary ammonium bacterial cellulose for adsorption of proteins Reviewed

    Teppei Niide, Hikaru Shiraki, Tatsuya Oshima, Yoshinari Baba, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   17   73 - 81   2010.1

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    DOI: 10.15261/serdj.17.73

  • Ionic liquid-assisted transdermal delivery of sparingly soluble drugs Reviewed

    Muhammad Moniruzzaman, Yoshiro Tahara, Miki Tamura, Noriho Kamiya, Masahiro Goto

    Chemical Communications   46 ( 9 )   1452 - 1454   2010

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    DOI: 10.1039/b907462g

  • Design of a molecular detection system by a DNA-regulated enzyme conjugate

    Josui Shimada, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   108   S112 - S112   2009.11

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    DOI: 10.1016/j.jbiosc.2009.08.327

  • New fluorescent substrates designed for covalent protein labeling catalyzed by microbial transglutaminase

    Noriho Kamiya, Hiroki Abe, Masahiro Goto, Yukiko Tsuji, Hiroyuki Jikuya

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   108   S97 - S97   2009.11

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    DOI: 10.1016/j.jbiosc.2009.08.283

  • Development and clarification of a novel transcutaneous protein delivery system and its mechanism by a solid-in-oil nanodispersion

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Masahiro Goto

    Journal of Bioscience and Bioengineering   108   pp.S39 - S40   2009.11

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    Development and clarification of a novel transcutaneous protein delivery system and its mechanism by a solid-in-oil nanodispersion

  • Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase Reviewed

    Tsuyoshi Mouri, Takeshi Shimizu, Noriho Kamiya, Masahiro Goto, Hirofumi Ichinose

    Biotechnology Progress   25 ( 5 )   1372 - 1378   2009.9

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    DOI: 10.1002/btpr.231

  • Design of a Cytochrome P450BM3 Reaction System Linked by Two-Step Cofactor Regeneration Catalyzed by a Soluble Transhydrogenase and Glycerol Dehydrogenase

    Tsuyoshi Mouri, Takeshi Shimizu, Noriho Kamiya, Masahiro Goto, Hirofumi Ichinose

    BIOTECHNOLOGY PROGRESS   25 ( 5 )   1372 - 1378   2009.9

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    DOI: 10.1002/btpr.231

  • Fluorescent substrates for covalent protein labeling catalyzed by microbial transglutaminase Reviewed

    Noriho Kamiya, Hiroki Abe, Masahiro Goto, Yukiko Tsuji, Hiroyuki Jikuya

    Organic and Biomolecular Chemistry   7 ( 17 )   3407 - 3412   2009.9

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    DOI: 10.1039/b904046c

  • Extraction behavior of indium with TOPO into ionic liquids Reviewed

    Fukiko Kubota, Yosuke Shimobori, Yusuke Koyanagi, Kazunori Nakashima, Kojiro Shimojo, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   16   151 - 155   2009.9

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  • 1Ep12 チロシンを介した新規タンパク質修飾技術の創製(タンパク質工学,一般講演)

    南畑 孝介, 神谷 典穂, 後藤 雅宏

    日本生物工学会大会講演要旨集   平成21年度   2009.8

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  • Enzyme encapsulation in microparticles composed of polymerized ionic liquids for highly active and reusable biocatalysts Reviewed International journal

    K. Nakashima, N. Kamiya, D. Koda, T. Maruyama, M. Goto

    Org. Biomol. Chem.   7   2009.7

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  • 生体分子のマイクロカプセルへの固定化とその応用 (特集 躍進するマイクロカプセルの最前線)

    清山 史朗, 南畑 孝介, 神谷 典穂

    ケミカルエンジニヤリング   54 ( 7 )   501 - 507   2009.7

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  • Solid–in–Oil化技術を利用したアスコルビン酸誘導体の経皮デリバリーシステム Reviewed

    大熊愛子, 朴洪宇, 田原義朗, 神谷典穂, 後藤雅宏

    膜   34 ( 4 )   227 - 232   2009.7

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    DOI: 10.5360/membrane.34.227

  • Development of a novel immobilization method for enzymes from hyperthermophiles

    Kosuke Minamihata, Masamichi Tokunaga, Noriho Kamiya, Shiro Kiyoyama, Haruhiko Sakuraba, Toshihisa Ohshima, Masahiro Goto

    BIOTECHNOLOGY LETTERS   31 ( 7 )   1037 - 1041   2009.7

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    DOI: 10.1007/s10529-009-9974-8

  • Development of a novel immobilization method for enzymes from hyperthermophiles Reviewed

    Kosuke Minamihata, Masamichi Tokunaga, Noriho Kamiya, Shiro Kiyoyama, Haruhiko Sakuraba, Toshihisa Ohshima, Masahiro Goto

    Biotechnology letters   31 ( 7 )   1037 - 1041   2009.7

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    DOI: 10.1007/s10529-009-9974-8

  • Enzyme encapsulation in microparticles composed of polymerized ionic liquids for highly active and reusable biocatalysts Reviewed

    Kazunori Nakashima, Noriho Kamiya, Daisuke Koda, Tatsuo Maruyama, Masahiro Goto

    Organic and Biomolecular Chemistry   7 ( 11 )   2353 - 2358   2009.6

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    DOI: 10.1039/b823064a

  • S/O化技術の魅力と新しい経皮薬物送達システム実現の可能性 Invited

    田原義朗, 神谷典穂, 後藤雅宏

    25   pp.1409 - 1414   2009.6

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  • Biocatalysis in Water-in-Ionic Liquid Microemulsions: A Case Study with Horseradish Peroxidase Reviewed International journal

    M.M.Zaman, N. Kamiya, M. Goto

    Langmuir   2009.4

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  • タンパク質の経皮デリバリーの実現 Invited

    田原義朗, 神谷典穂, 後藤雅宏

    バイオサイエンスとインダストリー   67   pp.68 - 70   2009.4

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  • Biocatalysis in water-in-ionic liquid microemulsions A case study with horseradish peroxidase Reviewed

    M. Moniruzzaman, N. Kamiya, M. Goto

    Langmuir   25 ( 2 )   977 - 982   2009.1

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    DOI: 10.1021/la803118q

  • Biocatalysis in Water-in-Ionic Liquid Microemulsions: A Case Study with Horseradish Peroxidase

    M. Moniruzzaman, N. Kamiya, A. Goto

    LANGMUIR   25 ( 2 )   977 - 982   2009.1

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    DOI: 10.1021/la803118q

  • Stimuli-responsive nanoparticles composed of naturally occurring amphiphilic proteins Reviewed

    Noriho Kamiya, Yoshiaki Shiotari, Masamichi Tokunaga, Hideshi Matsunaga, Hirokazu Yamanouchi, Koji Nakano, Masahiro Goto

    Chemical Communications   ( 35 )   5287 - 5289   2009

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    DOI: 10.1039/b909897f

  • Conjugation of DNA with protein using His-tag chemistry and its application to the aptamer-based detection system Reviewed

    Josui Shimada, Tatsuo Maruyama, Takuya Hosogi, Jo Tominaga, Noriho Kamiya, Masahiro Goto

    Biotechnology letters   30 ( 11 )   2001 - 2006   2008.11

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    DOI: 10.1007/s10529-008-9784-4

  • Conjugation of DNA with protein using His-tag chemistry and its application to the aptamer-based detection system

    Josui Shimada, Tatsuo Maruyama, Takuya Hosogi, Jo Tominaga, Noriho Kamiya, Masahiro Goto

    BIOTECHNOLOGY LETTERS   30 ( 11 )   2001 - 2006   2008.11

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    DOI: 10.1007/s10529-008-9784-4

  • A solid-in-oil nanodispersion for transcutaneous protein delivery Reviewed

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Hongyu Piao, Akihiko Hirata, Eiji Hayakawa, Takeru Fujii, Masahiro Goto

    Journal of Controlled Release   131 ( 1 )   14 - 18   2008.10

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    DOI: 10.1016/j.jconrel.2008.07.015

  • A solid-in-oil nanodispersion for transcutaneous protein delivery

    Yoshiro Tahara, Shota Honda, Noriho Kamiya, Hongyu Piao, Akihiko Hirata, Eiji Hayakawa, Takeru Fujii, Masahiro Goto

    JOURNAL OF CONTROLLED RELEASE   131 ( 1 )   14 - 18   2008.10

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    DOI: 10.1016/j.jconrel.2008.07.015

  • Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone Reviewed

    Hiromu Yoshiura, Yoshiro Tahara, Masakazu Hashida, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, Masahiro Goto

    Biochemical Engineering Journal   41 ( 2 )   106 - 110   2008.9

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    DOI: 10.1016/j.bej.2008.04.001

  • Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone

    Hiromu Yoshiura, Yoshiro Tahara, Masakazu Hashida, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, Masahiro Goto

    BIOCHEMICAL ENGINEERING JOURNAL   41 ( 2 )   106 - 110   2008.9

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    DOI: 10.1016/j.bej.2008.04.001

  • Extraction of lanthanide ions with an organophosphorous extractant into ionic liquids Reviewed

    Fukiko Kubota, Yusuke Koyanagi, Kazunori Nakashima, Kojiro Shimojo, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   15   81 - 87   2008.9

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  • Microcapsulation of DNA and the adsorption of toxic substances Reviewed

    Shiro Kiyoyama, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Journal of Microencapsulation   25 ( 5 )   324 - 329   2008.8

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    DOI: 10.1080/02652040801990741

  • Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. International journal

    H. Piao, N. Kamiya, A. Hirata, T. Fujii, I. Shimizu, S. Ito, M. Goto

    Pharm. Devel. Technol.   2008.7

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  • A chemically modified glass surface that facilitates transglutaminase- mediated protein immobilization Reviewed

    Yusuke Tanaka, Satoshi Doi, Noriho Kamiya, Noriyuki Kawata, Shinji Kamiya, Kenichi Nakama, Masahiro Goto

    Biotechnology letters   30 ( 6 )   1025 - 1029   2008.6

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    DOI: 10.1007/s10529-008-9656-y

  • Enzymatic in situ saccharification of cellulose in aqueous-ionic liquid media

    Noriho Kamiya, Yuichi Matsushita, Misa Hanaki, Kazunori Nakashima, Mamiko Narita, Masahiro Goto, Haruo Takahashi

    BIOTECHNOLOGY LETTERS   30 ( 6 )   1037 - 1040   2008.6

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    DOI: 10.1007/s10529-008-9638-0

  • A chemically modified glass surface that facilitates transglutaminase-mediated protein immobilization

    Yusuke Tanaka, Satoshi Doi, Noriho Kamiya, Noriyuki Kawata, Shinji Kamiya, Kenichi Nakama, Masahiro Goto

    BIOTECHNOLOGY LETTERS   30 ( 6 )   1025 - 1029   2008.6

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    DOI: 10.1007/s10529-008-9656-y

  • Enzymatic in situ saccharification of cellulose in aqueous-ionic liquid media Reviewed

    Noriho Kamiya, Yuichi Matsushita, Misa Hanaki, Kazunori Nakashima, Mamiko Narita, Masahiro Goto, Haruo Takahashi

    Biotechnology letters   30 ( 6 )   1037 - 1040   2008.6

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    DOI: 10.1007/s10529-008-9638-0

  • Water-in-ionic liquid microemulsions as a new medium for enzymatic reactions Reviewed

    Muhammad Moniruzzaman, Noriho Kamiya, Kazunori Nakashima, Masahiro Goto

    Green Chemistry   10 ( 5 )   497 - 450   2008.5

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    DOI: 10.1039/b802501k

  • A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium Reviewed

    Hongyu Piao, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, Masahiro Goto

    Pharmaceutical Research   25 ( 4 )   896 - 901   2008.4

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    DOI: 10.1007/s11095-007-9445-7

  • Formation of reverse micelles in a room-temperature ionic liquid

    Muhammad Moniruzzaman, Kamiya Noriho, Kazunori Nakashima, Masahiro Goto

    CHEMPHYSCHEM   9 ( 5 )   689 - 692   2008.4

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    DOI: 10.1002/cphc.200700802

  • A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium

    Hongyu Piao, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, Masahiro Goto

    PHARMACEUTICAL RESEARCH   25 ( 4 )   896 - 901   2008.4

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    DOI: 10.1007/s11095-007-9445-7

  • Formation of reverse micelles in a room-temperature ionic liquid Reviewed

    Muhammad Moniruzzaman, Noriho Kamiya, Kazunori Nakashima, Masahiro Goto

    ChemPhysChem   9 ( 5 )   689 - 692   2008.4

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    DOI: 10.1002/cphc.200700802

  • Immobilization of proteins into microcapsules and their adsorption properties with respect to precious-metal ions Reviewed

    Shiro Kiyoyama, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Industrial and Engineering Chemistry Research   47 ( 5 )   1527 - 1532   2008.3

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    DOI: 10.1021/ie0712636

  • Spectrophotometric assay for protease activity in ionic liquids using chromogenic substrates

    Kazunorl Nakashima, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    ANALYTICAL BIOCHEMISTRY   374 ( 2 )   285 - 290   2008.3

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    DOI: 10.1016/j.ab.2007.11.015

  • Immobilization of proteins into microcapsules and their adsorption properties with respect to precious-metal ions

    Shiro Kiyoyama, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH   47 ( 5 )   1527 - 1532   2008.3

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    DOI: 10.1021/ie0712636

  • A rapid assay of protease activity in ionic liquids using chromogenic substrates Reviewed

    Kazunori Nakashima, Tatsuo Maruyama, Masahiro Goto, Noriho Kamiya

    Analytical Biochemistry   Vol. 374 Issue: 2 Pages: 2   2008.3

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    A rapid assay of protease activity in ionic liquids using chromogenic substrates

  • Spectrophotometric assay for protease activity in ionic liquids using chromogenic substrates Reviewed

    Kazunori Nakashima, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   374 ( 2 )   285 - 290   2008.3

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    DOI: 10.1016/j.ab.2007.11.015

  • Functional immobilization of recombinant alkaline phosphatases bearing a glutamyl donor substrate peptide of microbial transglutaminase Reviewed

    Noriho Kamiya, Satoshi Doi, Yusuke Tanaka, Hirofumi Ichinose, Masahiro Goto

    Journal of Bioscience and Bioengineering   104 ( 3 )   195 - 199   2007.9

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    DOI: 10.1263/jbb.104.195

  • Intramolecular electron transfer in a cytochrome P450cam system with a site-specific branched structure

    Hidehiko Hirakawa, Noriho Kamiya, Tsutomu Tanaka, Teruyuki Nagamune

    PROTEIN ENGINEERING DESIGN & SELECTION   20 ( 9 )   453 - 459   2007.9

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    DOI: 10.1039/protein/gzm045

  • Functional immobilization of recombinant alkaline phosphatases bearing a glutarnyl donor substrate peptide of microbial transglutaminase

    Noriho Kamiya, Satoshi Doi, Yusuke Tanaka, Hirofumi Ichinose, Masahiro Goto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   104 ( 3 )   195 - 199   2007.9

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    DOI: 10.1263/jbb.104.195

  • Intramolecular electron transfer in a cytochrome P450cam system with a site-specific branched structure Reviewed

    Hidehiko Hirakawa, Noriho Kamiya, Tsutomu Tanaka, Teruyuki Nagamune

    Protein Engineering, Design and Selection   20 ( 9 )   453 - 459   2007.9

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    DOI: 10.1093/protein/gzm045

  • Extraction of cytochrome c by a functionalized ionic liquid containing a crown ether Reviewed

    Fukiko Kubota, Yusuke Koyanagi, Kazunori Nakashima, Kojiro Shimojo, Noriho Kamiya, Masahiro Goto

    Solvent Extraction Research and Development   14   115 - 120   2007.8

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  • Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions. Reviewed International journal

    H. Yoshiura, M. Hashida, N. Kamiya, M. Goto

    Int. J. Pharm., 338, 174-179 (2007)   2007.7

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  • Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions Reviewed

    Hiromu Yoshiura, Masakazu Hashida, Noriho Kamiya, Masahiro Goto

    International Journal of Pharmaceutics   338 ( 1-2 )   174 - 179   2007.6

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    DOI: 10.1016/j.ijpharm.2007.01.041

  • Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions

    Hiromu Yoshiura, Masakazu Hashida, Noriho Kamiya, Masahiro Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   338 ( 1-2 )   174 - 179   2007.6

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    DOI: 10.1016/j.ijpharm.2007.01.041

  • An enzyme-labeled protein polymer bearing pendent haptens Reviewed

    Jo Tominaga, Noriho Kamiya, Masahiro Goto

    Bioconjugate Chemistry   18 ( 3 )   860 - 865   2007.5

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    DOI: 10.1021/bc060161d

  • An enzyme-labeled protein polymer bearing pendent haptens

    Jo Tominaga, Noriho Kamiya, Masahiro Goto

    BIOCONJUGATE CHEMISTRY   18 ( 3 )   860 - 865   2007.5

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    DOI: 10.1021/bc060161d

  • Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension Reviewed

    Hongyu Piao, Akihiko Hirata, Hideakira Yokoyama, Takeru Fujii, Ichiro Shimizu, Susumu Ito, Noriho Kamiya, Masahiro Goto

    Pharmaceutical Development and Technology   12 ( 3 )   321 - 325   2007.5

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    DOI: 10.1080/10837450701247517

  • Proteins and protein-rich biomass as environmental-friendly adsorbents selective for precious metal ions Reviewed International journal

    T. Maruyama, Y. Shimada, H. Matsushita, N. Kamiya, M. Goto

    Env. Sci. Technol.   2007.2

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  • Proteins and protein-rich biomass as environmentally friendly adsorbents selective for precious metal ions

    Tatsuo Maruyama, Hironari Matsushita, Yukiko Shimada, Ichiro Kamata, Misa Hanaki, Saori Sonokawa, Noriho Kamiya, Masahiro Goto

    ENVIRONMENTAL SCIENCE & TECHNOLOGY   41 ( 4 )   1359 - 1364   2007.2

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    DOI: 10.1021/es061664x

  • Proteins and protein-rich biomass as environmentally friendly adsorbents selective for precious metal ions Reviewed

    Tatsuo Maruyama, Hironari Matsushita, Yukiko Shimada, Ichiro Kamata, Misa Hanaki, Saori Sonokawa, Noriho Kamiya, Masahiro Goto

    Environmental Science and Technology   41 ( 4 )   1359 - 1364   2007.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/es061664x

  • An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides Reviewed

    Jo Tominaga, Yoshinori Kemori, Yusuke Tanaka, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Chemical Communications   ( 4 )   401 - 403   2007.1

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    DOI: 10.1039/b613793h

  • Exploring enzymatic catalysis at a solid surface A case study with transglutaminase-mediated protein immobilization Reviewed

    Yusuke Tanaka, Yukito Tsuruda, Motohiro Nishi, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   5 ( 11 )   1764 - 1770   2007

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    DOI: 10.1039/b701595j

  • Intramolecular electron transfer in a novel cytochrome P450cam system with a site-specific branched structure

    Hidehiko Hirakawa, Noriho Kamiya, Tsutomu Tanaka, Teruyuki Nagamune

    2006 AIChE Annual Meeting 2006 AIChE Annual Meeting   2006.12

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  • Extractive solubilization, structural change, and functional conversion of cytochrome c in ionic liquids via crown ether complexation Reviewed

    Kojiro Shimojo, Noriho Kamiya, Fumito Tani, Hirochika Naganawa, Yoshinori Naruta, Masahiro Goto

    Analytical chemistry   78 ( 22 )   7735 - 7742   2006.11

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    DOI: 10.1021/ac0612877

  • Extractive solubilization, structural change, and functional conversion of cytochrome c in ionic liquids via crown ether complexation

    Kojiro Shimojo, Noriho Kamiya, Fumito Tani, Hirochika Naganawa, Yoshinori Naruta, Masahiro Goto

    ANALYTICAL CHEMISTRY   78 ( 22 )   7735 - 7742   2006.11

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    DOI: 10.1021/ac0612877

  • Extractive Solubilization, Structural Change and Functional Conversion of Cytochrome c in Ionic Liquids via Crown Ether Complexation Reviewed International journal

    K. Shimojo, N. Kamiya, F. Tani, H. Naganawa, Y. Naruta, M. Goto

    Anal. Chem.   2006.10

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  • Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol)

    Kazunori Nakashima, Jun Okada, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   7 ( 7 )   692 - 698   2006.10

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    DOI: 10.1016/j.stam.2006.06.008

  • Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol) Reviewed

    Kazunori Nakashima, Jun Okada, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Science and Technology of Advanced Materials   7 ( 7 )   692 - 698   2006.10

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    DOI: 10.1016/j.stam.2006.06.008

  • Crown-ether mediated extraction and functional conversion of cytochrome c in ionic liquids Reviewed International journal

    K.Shimojo, K.Nakashima, N.Kamiya, M.Goto

    Biomacromolecules   2006.10

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  • A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration Reviewed

    Tsuyoshi Mouri, Junji Michizoe, Hirofumi Ichinose, Noriho Kamiya, Masahiro Goto

    Applied Microbiology and Biotechnology   72 ( 3 )   514 - 520   2006.9

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    DOI: 10.1007/s00253-005-0289-y

  • Increasing the catalytic performance of a whole cell biocatalyst harboring a cytochrome P450cam system by stabilization of an electron transfer component

    Tsuyoshi Mouri, Noriho Kamiya, Masahiro Goto

    BIOTECHNOLOGY LETTERS   28 ( 18 )   1509 - 1513   2006.9

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    DOI: 10.1007/s10529-006-9118-3

  • A recombinant Escherichia coli whole cell biocatalyst harboring a cytochrome P450cam monooxygenase system coupled with enzymatic cofactor regeneration

    Tsuyoshi Mouri, Junji Michizoe, Hirofumi Ichinose, Noriho Kamiya, Masahiro Goto

    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   72 ( 3 )   514 - 520   2006.9

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    DOI: 10.1007/s00253-005-0289-y

  • Increasing the catalytic performance of a whole cell biocatalyst harboring a cytochrome P450cam system by stabilization of an electron transfer component Reviewed

    Tsuyoshi Mouri, Noriho Kamiya, Masahiro Goto

    Biotechnology letters   28 ( 18 )   1509 - 1513   2006.9

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    DOI: 10.1007/s10529-006-9118-3

  • Homogeneous enzymatic reactions in ionic liquids with poly(ethylene glycol)-modified subtilisin Reviewed

    Kazunori Nakashima, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   4 ( 18 )   3462 - 3467   2006.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/b608920h

  • Masking oligonucleotides improve sensitivity of mutation detection based on guanine quenching Reviewed International journal

    T. Maruyama, T. Shinohara, T. Hosogi, H. Ichinose, N. Kamiya, M. Goto

    Anal. Biochem.   2006.7

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  • Masking oligonucleotides improve sensitivity of mutation detection based on guanine quenching

    T Maruyama, T Shinohara, T Hosogi, H Ichinose, N Kamiya, M Goto

    ANALYTICAL BIOCHEMISTRY   354 ( 1 )   8 - 14   2006.7

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    DOI: 10.1016/j.ab.2006.03.056

  • Masking oligonucleotides improve sensitivity of mutation detection based on guanine quenching Reviewed

    Tatsuo Maruyama, Toshimitsu Shinohara, Takuya Hosogi, Hirofumi Ichinose, Noriho Kamiya, Masahiro Goto

    Analytical Biochemistry   354 ( 1 )   8 - 14   2006.7

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    DOI: 10.1016/j.ab.2006.03.056

  • Oral delivery of diclofenac sodium using a novel solid-in-oil suspension Reviewed

    Hongyu Piao, Noriho Kamiya, Junji Watanabe, Hideakira Yokoyama, Akihiko Hirata, Takeru Fujii, Ichiro Shimizu, Susumu Ito, Masahiro Goto

    International Journal of Pharmaceutics   313 ( 1-2 )   159 - 162   2006.4

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    DOI: 10.1016/j.ijpharm.2006.02.003

  • Oral delivery of diclofenac sodium using a novel solid-in-oil suspension

    H Piao, N Kamiya, J Watanabe, H Yokoyama, A Hirata, T Fujii, Shimizu, I, S Ito, M Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   313 ( 1-2 )   159 - 162   2006.4

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    DOI: 10.1016/j.ijpharm.2006.02.003

  • Crown ether-mediated extraction and functional conversion of cytochrome c in ionic liquids Reviewed

    Kojiro Shimojo, Kazunori Nakashima, Noriho Kamiya, Masahiro Goto

    Biomacromolecules   7 ( 1 )   2 - 5   2006.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bm050847t

  • Crown ether-mediated extraction and functional conversion of cytochrome c in ionic liquids

    Kojiro Shimojo, Kazunori Nakashima, Noriho Kamiya, Masahiro Goto

    Biomacromolecules   7 ( 1 )   2 - 5   2006.1

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    DOI: 10.1021/bm050847t

  • Solubilization and high activity of enzymes in ionic liquids by modification with comb-shaped poly (ethylene glycol)

    Kazunori Nakashima, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Polymer Preprints, Japan   54   4647 - 4648   2005.12

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    Solubilization and high activity of enzymes in ionic liquids by modification with comb-shaped poly (ethylene glycol)
    Subtilisin Carlsberg was modified with comb-shaped poly (ethylene glycol), PM13. PM13 modified subtilisin (PM13-Sub) could be solubilized clearly in a wide range of pure ILs, whereas native subtilisin was not soluble in any ILs. Furthermore, PM13-Sub dissolved in ILs exhibited the excellent catalytic activity in transesterification of N-acetyl-L-phenylalanine ethyl ester with 1-butanol. This markedly high activity in the IL was superior to that in organic solvents commonly used for enzymatic catalysis. PM13-Sub was also found to retain its catalytic activity in the ILs for a prolonged period.

  • 油と界面活性剤を基材とするドラッグデリバリーシステム--新規脂質複合型経口製剤の開発に向けて (特集 次世代バイオテクノロジーの展開)

    神谷 典穂, 後藤 雅宏

    ケミカルエンジニヤリング   50 ( 12 )   924 - 928   2005.12

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  • Detection of single-base mutations by fluorogenic ribonuclease protection assay Reviewed

    Hirofumi Ichinose, Momoko Kitaoka, Nobuko Okamura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Analytical chemistry   77 ( 21 )   7047 - 7053   2005.11

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    DOI: 10.1021/ac050782k

  • Detection of single-base mutations by fluorogenic ribonuclease protection assay

    H Ichinose, M Kitaoka, N Okamura, T Maruyama, N Kamiya, M Goto

    ANALYTICAL CHEMISTRY   77 ( 21 )   7047 - 7053   2005.11

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    DOI: 10.1021/ac050782k

  • An enteric-coated dry emulsion formulation for oral insulin delivery Reviewed

    Eiichi Toorisaka, Masakazu Hashida, Noriho Kamiya, Hiroshige Ono, Yuko Kokazu, Masahiro Goto

    Journal of Controlled Release   107 ( 1 )   91 - 96   2005.9

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    DOI: 10.1016/j.jconrel.2005.05.022

  • Mutation detection in DNA oligonucleotides based on a guanine quenching method coupled with enzymatic digestion of single-stranded DNA

    T Maruyama, T Shinohara, H Ichinose, M Kitaoka, N Okamura, N Kamiya, M Goto

    BIOTECHNOLOGY LETTERS   27 ( 18 )   1349 - 1354   2005.9

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    DOI: 10.1007/s10529-005-3681-x

  • An enteric-coated dry emulsion formulation for oral insulin delivery

    E Toorisaka, M Hashida, N Kamiya, H Ono, Y Kokazu, M Goto

    JOURNAL OF CONTROLLED RELEASE   107 ( 1 )   91 - 96   2005.9

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    DOI: 10.1016/j.jconrel.2005.05.022

  • Mutation detection in DNA oligonucleotides based on a guanine quenching method coupled with enzymatic digestion of single-stranded DNA Reviewed

    Tatsuo Maruyama, Toshimitsu Shinohara, Hirofumi Ichinose, Momoko Kitaoka, Nobuko Okamura, Noriho Kamiya, Masahiro Goto

    Biotechnology letters   27 ( 18 )   1349 - 1354   2005.9

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    DOI: 10.1007/s10529-005-3681-x

  • Comb-shaped poly(ethylene glycol)-modified subtilisin Carlsberg is soluble and highly active in ionic liquids Reviewed

    Kazunori Nakashima, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Chemical Communications   ( 34 )   4297 - 4299   2005.9

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    DOI: 10.1039/b505479f

  • Enzymatic redox cofactor regeneration in organic media Functionalization and application of glycerol dehydrogenase and soluble transhydrogenase in reverse micelles Reviewed

    Hirofumi Ichinose, Noriho Kamiya, Masahiro Goto

    Biotechnology Progress   21 ( 4 )   1192 - 1197   2005.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bp0500765

  • Enzymatic redox cofactor regeneration in organic media: Functionalization and application of glycerol dehydrogenase and soluble transhydrogenase in reverse micelles

    H Ichinose, N Kamiya, M Goto

    BIOTECHNOLOGY PROGRESS   21 ( 4 )   1192 - 1197   2005.7

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    DOI: 10.1021/bp0500765

  • Design of a specific peptide tag that affords covalent and site-specific enzyme immobilization catalyzed by microbial transglutaminase

    J Tominaga, N Kamiya, S Doi, H Ichinose, T Maruyama, M Goto

    BIOMACROMOLECULES   6 ( 4 )   2299 - 2304   2005.7

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    DOI: 10.1021/bm050193o

  • Biodegradation of phenolic environmental pollutants by a surfactant-laccase complex in organic media

    Y Michizoe, H Ichinose, N Kamiya, T Maruyama, M Goto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   99 ( 6 )   642 - 647   2005.6

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    DOI: 10.1263/jbb.99.642

  • Optical resolution of various amino acids using a supported liquid membrane encapsulating a surfactant-protease complex Reviewed

    Eijiro Miyako, Tatsuo Maruyama, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Langmuir   21 ( 10 )   4674 - 4679   2005.5

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    DOI: 10.1021/la046789z

  • Optical resolution of various amino acids using a supported liquid membrane encapsulating a surfactant-protease complex

    E Miyako, T Maruyama, F Kubota, N Kamiya, M Goto

    LANGMUIR   21 ( 10 )   4674 - 4679   2005.5

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    DOI: 10.1021/la046789z

  • Log P effect of organic solvents on a thermophilic alcohol dehydrogenase Reviewed

    Hidehiko Hirakawa, Noriho Kamiya, Yutaka Kawarabayashi, Teruyuki Nagamune

    Biochimica et Biophysica Acta - Proteins and Proteomics   1748 ( 1 )   94 - 99   2005.4

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    DOI: 10.1016/j.bbapap.2004.12.007

  • N-terminal glycine-specific protein conjugation catalyzed by microbial transglutaminase

    T Tanaka, N Kamiya, T Nagamune

    FEBS LETTERS   579 ( 10 )   2092 - 2096   2005.4

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    DOI: 10.1016/j.febslet.2005.02.064

  • Metal ion-selective membrane prepared by surface molecular imprinting

    K Araki, T Maruyama, N Kamiya, M Goto

    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES   818 ( 2 )   141 - 145   2005.4

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    DOI: 10.1016/j.jchromb.2004.12.030

  • Log P effect of organic solvents on a thermophilic alcohol dehydrogenase

    H Hirakawa, N Kamiya, Y Kawarabayashi, T Nagamune

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   1748 ( 1 )   94 - 99   2005.4

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    DOI: 10.1016/j.bbapap.2004.12.007

  • Activation of a Thermophilic Alcohol Dehydrogenase by Organic Solvents Reviewed

    Hirakawa, Hidehiko, Kamiya, Noriho, Kawarabayashi, Yutaka, Nagamune, Teruyuki

    Asian Pacific Confederation of Chemical Engineering congress program and abstracts   2005.4

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    Activation of a Thermophilic Alcohol Dehydrogenase by Organic Solvents

    DOI: 10.11491/apcche.2004.0.435.0

  • Metal ion-selective membrane prepared by surface molecular imprinting Reviewed

    Kosuke Araki, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   818 ( 2 )   141 - 145   2005.4

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    DOI: 10.1016/j.jchromb.2004.12.030

  • Detection of point mutations in the HBV polymerase gene using a fluorescence intercalator in reverse micelles Reviewed

    Tatsuo Maruyama, Tomoaki Takata, Hirofumi Ichinose, Noriho Kamiya, Hiroyuki Kuma, Naotaka Hamasaki, Hiroyuki Morita, Masahiro Goto

    Biotechnology Progress   21 ( 2 )   575 - 579   2005.3

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    DOI: 10.1021/bp0496474

  • Detection of point mutations in the HBV polymerase gene using a fluorescence intercalator in reverse micelles

    T Maruyama, T Takata, H Ichinose, N Kamiya, H Kuma, N Hamasaki, H Morita, M Goto

    BIOTECHNOLOGY PROGRESS   21 ( 2 )   575 - 579   2005.3

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    DOI: 10.1021/bp0496474

  • A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids Reviewed

    Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Chemistry - A European Journal   11 ( 4 )   1163 - 1170   2005.2

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    DOI: 10.1002/chem.200400691

  • APCChE2004 : The 10th Congress of the Asian Pacific Confederation of Chemical Engineering

    63 ( 2 )   105 - 106   2005.2

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    APCChE2004 : The 10th Congress of the Asian Pacific Confederation of Chemical Engineering

  • A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids

    E Miyako, T Maruyama, N Kamiya, M Goto

    CHEMISTRY-A EUROPEAN JOURNAL   11 ( 4 )   1163 - 1170   2005.2

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    DOI: 10.1002/chem.200400691

  • Biodegradation of phenolic environmental pollutants by a surfactant-laccase complex in organic media Reviewed

    Junji Michizoe, Hirofumi Ichinose, Noriho Kamiya, Tatsuo Maruyama, Masahiro Goto

    Journal of Bioscience and Bioengineering   99 ( 6 )   642 - 647   2005.1

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    DOI: 10.1263/jbb.99.642

  • Transglutaminase-mediated protein immobilization to casein nanolayers created on a plastic surface

    N Kamiya, S Doi, J Tominaga, H Ichinose, M Goto

    BIOMACROMOLECULES   6 ( 1 )   35 - 38   2005.1

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    DOI: 10.1021/bm0494895

  • Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions

    J Michizoe, H Ichinose, N Kamiya, T Maruyama, M Goto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   99 ( 1 )   12 - 17   2005.1

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    DOI: 10.1263/jbb.99.012

  • Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions Reviewed

    Junji Michizoe, Hirofumi Ichinose, Noriho Kamiya, Tatsuo Maruyama, Masahiro Goto

    Journal of Bioscience and Bioengineering   99 ( 1 )   12 - 17   2005.1

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    DOI: 10.1263/jbb.99.12

  • An enzymatic strategy for site-specific immobilization of functional proteins using microbial transglutaminase Reviewed

    Jo Tominaga, Noriho Kamiya, Satoshi Doi, Hirofumi Ichinose, Masahiro Goto

    Enzyme and Microbial Technology   35 ( 6-7 )   613 - 618   2004.12

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    DOI: 10.1016/j.enzmictec.2004.08.014

  • Poly(ethylene glycol)-lipase complex highly active in ionic liquids

    Masahiro Goto, Tatsuo Maruyama, Noriho Kamiya

    AIChE Annual Meeting, Conference Proceedings   8711 - 8715   2004.12

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    Poly(ethylene glycol)-lipase complex highly active in ionic liquids
    The alcoholysis catalyzed by the poly(ethylene glycol) (PEG)-lipase complex in ionic liquids was investigated. The alcoholysis between vinyl cinnamete and benzyl alcohol was catalyzed by lyophilized native lipase PS or the PEG-lipase PS complex in [Hmin][PF6]. The alcoholysis reaction involves acylation of the lipase and esterification of benzyl alcohol. The results show that the differences in activation among lipases was related to the solvent tolerance of the lipase or the dispersion of the PEG-lipase complexes.

  • An enzymatic strategy for site-specific immobilization of functional proteins using microbial transglutaminase

    J Tominaga, N Kamiya, S Doi, H Ichinose, M Goto

    ENZYME AND MICROBIAL TECHNOLOGY   35 ( 6-7 )   613 - 618   2004.12

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    DOI: 10.1016/j.enzmictec.2004.08.014

  • Direct refolding of inclusion bodies using reversed micelles Reviewed

    Masafumi Sakono, Yu Mi Kawashima, Hirofumi Ichinose, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Biotechnology Progress   20 ( 6 )   1783 - 1787   2004.11

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    DOI: 10.1021/bp049887j

  • 逆ミセルによるインクルージョンボディの高効率リフォールディング Reviewed

    迫野昌文, 河嶋優美, 一瀬博文, 丸山 達生, 神谷 典穂, 後藤雅宏

    化学工学論文集   Volume: 30 Issue: 4 Page   2004.11

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  • 有機酸の選択的分離が可能なリパーゼ-オルガノゲル膜システムの開発 Reviewed

    都英次郎, 丸山 達生, 神谷典穂, 後藤雅宏

    膜(Membrane)   29, 236-243   2004.11

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  • Mutation detection in the drug-resistant hepatitis B virus polymerase gene using nanostructured reverse micelles

    LC Park, T Maruyama, N Kamiya, M Goto, H Kuma, N Hamasaki

    ANALYTICAL SCIENCES   20 ( 11 )   1609 - 1611   2004.11

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    DOI: 10.2116/analsci.20.1609

  • Direct refolding of inclusion bodies using reversed micelles

    M Sakono, YM Kawashima, H Ichinose, T Maruyama, N Kamiya, M Goto

    BIOTECHNOLOGY PROGRESS   20 ( 6 )   1783 - 1787   2004.11

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    DOI: 10.1021/bp049887j

  • Mutation detection in the drug-resistant hepatitis B virus polymerase gene using nanostructured reverse micelles Reviewed

    Lian Chun Park, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto, Hiroyuki Kuma, Naotaka Hamasaki

    analytical sciences   20 ( 11 )   1609 - 1611   2004.11

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    DOI: 10.2116/analsci.20.1609

  • Intermittent partition walls promote solvent extraction of metal ions in a microfluidic device Reviewed

    Tatsuo Maruyama, Tomoaki Kaji, Tomohiro Ohkawa, Ken Ichiro Sotowa, Hironari Matsushita, Fukiko Kubota, Noriho Kamiya, Katsuki Kusakabe, Masahiro Goto

    Analyst   129 ( 11 )   1008 - 1013   2004.11

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    DOI: 10.1039/b411630p

  • Liquid membrane operations in a microfluidic device for separation of metal ions Reviewed

    Tatsuo Maruyama, Hironari Matsushita, Jun Ichi Uchida, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Analytical Chemistry   76 ( 15 )   4495 - 4500   2004.8

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    DOI: 10.1021/ac049844h

  • Liquid membrane operations in a microfluidic device for selective separation of metal ions

    T Maruyama, H Matsushita, J Uchida, F Kubota, N Kamiya, M Goto

    ANALYTICAL CHEMISTRY   76 ( 15 )   4495 - 4500   2004.8

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    DOI: 10.1021/ac049844h

  • Efficient refolding of inclusion bodies by reversed micelles Reviewed

    Masafumi Sakono, Yu Mi Kawashima, Hirofumi Ichinose, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    kagaku kogaku ronbunshu   30 ( 4 )   468 - 473   2004.7

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    DOI: 10.1252/kakoronbunshu.30.468

  • Refolding of denatured carbonic anhydrase B by reversed micelles formulated with nonionic surfactant

    M Sakono, T Maruyama, N Kamiya, M Goto

    BIOCHEMICAL ENGINEERING JOURNAL   19 ( 3 )   217 - 220   2004.7

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    DOI: 10.1016/j.bej.2004.01.003

  • Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

    E Miyako, T Maruyama, N Kamiya, M Goto

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   126 ( 28 )   8622 - 8623   2004.7

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    DOI: 10.1021/ja049378d

  • Efficient refolding of inclusion bodies by reversed micelles

    M Sakono, Y Kawashima, H Ichinose, T Maruyama, N Kamiya, M Goto

    KAGAKU KOGAKU RONBUNSHU   30 ( 4 )   468 - 473   2004.7

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    DOI: 10.1252/kakoronbunshu.30.468

  • Activation of manganese peroxidase in an organic medium using a mediator

    J Michizoe, Y Uchimura, H Ichinose, T Maruyama, N Kamiya, H Wariishi, S Furusaki, M Goto

    BIOCHEMICAL ENGINEERING JOURNAL   19 ( 1 )   43 - 46   2004.7

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    DOI: 10.1016/j.bej.2003.09.008

  • Refolding of denatured carbonic anhydrase B by reversed micelles formulated with nonionic surfactant Reviewed

    Masafumi Sakono, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Biochemical Engineering Journal   19 ( 3 )   217 - 220   2004.7

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    DOI: 10.1016/j.bej.2004.01.003

  • Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex Reviewed

    Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Journal of the American Chemical Society   126 ( 28 )   8622 - 8623   2004.7

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    DOI: 10.1021/ja049378d

  • Electron-transfer reactions and functionalization of cytochrome P450cam monooxygenase system in reverse micelles

    H Ichinose, J Michizoe, T Maruyama, N Kamiya, M Goto

    LANGMUIR   20 ( 13 )   5564 - 5568   2004.6

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    DOI: 10.1021/la049752n

  • Enzymatic labeling of a single chain variable fragment of an antibody with alkaline phosphatase by microbial transglutaminase Reviewed

    Takeshi Takazawa, Noriho Kamiya, Hiroshi Ueda, Teruyuki Nagamune

    Biotechnology and Bioengineering   86 ( 4 )   399 - 404   2004.5

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    DOI: 10.1002/bit.20019

  • Peptidyl linkers for protein heterodimerization catalyzed by microbial transglutaminase

    T Tanaka, N Kamiya, T Nagamune

    BIOCONJUGATE CHEMISTRY   15 ( 3 )   491 - 497   2004.5

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    DOI: 10.1021/bc034209o

  • Enzymatic labeling of a single chain variable fragment of an antibody with alkaline phosphatase by mircobial transglutaminase

    T Takazawa, N Kamiya, H Ueda, T Nagamune

    BIOTECHNOLOGY AND BIOENGINEERING   86 ( 4 )   399 - 404   2004.5

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    DOI: 10.1002/bit.20019

  • Peptidyl linkers for protein heterodimerization catalyzed by microbial transglutaminase Reviewed

    Tsutomu Tanaka, Noriho Kamiya, Teruyuki Nagamune

    Bioconjugate Chemistry   15 ( 3 )   491 - 497   2004.5

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    DOI: 10.1021/bc034209o

  • Poly(ethylene glycol)-lipase complexes that are highly active and enantioselective in ionic liquids Reviewed

    Tatsuo Maruyama, Hiroshi Yamamura, Takahiro Kotani, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   2 ( 8 )   1239 - 1244   2004.4

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    DOI: 10.1039/b401012d

  • Solid-phase peptide synthesis in a microfluidic device Reviewed

    Tatsuo Maruyama, Jun Ichi Uchida, Tomohiro Ohkawa, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    kagaku kogaku ronbunshu   30 ( 2 )   180 - 182   2004.3

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    DOI: 10.1252/kakoronbunshu.30.180

  • マイクロ流体デバイスを用いたオリゴペプチドの固相合成 Reviewed

    丸山 達生, 内田純一, 大川朋裕, 久保田富生子, 神谷典穂, 後藤雅宏

    化学工学論文集   Volume: 30 Issue: 2 Pages:   2004.3

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  • Solid-phase peptide synthesis in a microfluidic device

    T Maruyama, J Uchida, T Ohkawa, F Kubota, N Kamiya, M Goto

    KAGAKU KOGAKU RONBUNSHU   30 ( 2 )   180 - 182   2004.3

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    DOI: 10.1252/kakoronbunshu.30.180

  • Poly(ethylene glycol)-lipase complexes catalytically active in fluorous solvents Reviewed

    Tatsuo Maruyama, Takahiro Kotani, Hiroshi Yamamura, Noriho Kamiya, Masahiro Goto

    Organic and Biomolecular Chemistry   2 ( 4 )   524 - 527   2004.2

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    DOI: 10.1039/b312212c

  • Poly(ethylene glycol)-lipase complexes catalytically active in fluorous solvents

    T Maruyama, T Kotani, H Yamamura, N Kamiya, M Goto

    ORGANIC & BIOMOLECULAR CHEMISTRY   2 ( 4 )   524 - 527   2004.2

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    DOI: 10.1039/b312212c

  • Electron transfer reaction and functionalization of P450cam system in reverse micelles Reviewed International journal

    H.Ichinose, J.Michizoe, T.Maruyama, N.Kamiya, M.Goto

    Langmuir   20 ( 13 )   5564 - 5568   2004.1

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    DOI: 10.1021/la049752n

  • Erratum Enzymatic degradation of p-chlorophenol in a two-phase flow microchannel system (Lab on a chip - Miniaturisation for Chemistry, Biology & Bioengineering (2003) 3 (308) (DOI: 10.1039/b309982b)) Reviewed

    Tatsuo Maruyama, Jun Ichi Uchida, Tomohiro Ohkawa, Toru Futami, Koji Katayama, Kei Ichiro Nishizawa, Ken Ichiro Sotowa, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Lab on a Chip   4 ( 2 )   2004.1

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  • Rational design of a protein-based molecular device consisting of blue fluorescent protein and zinc protoporphyrin IX incorporated into a cytochrome b(562) scaffold

    S Takeda, N Kamiya, T Nagamune

    BIOTECHNOLOGY LETTERS   26 ( 2 )   121 - 125   2004.1

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    DOI: 10.1023/B:BILE.0000012889.24412.ca

  • Erratum: Enzymatic degradation of p-chlorophenol in a two-phase flow microchannel system (Lab on a chip - Miniaturisation for Chemistry, Biology & Bioengineering (2003) 3 (308) (DOI: 10.1039/b309982b))

    Tatsuo Maruyama, Jun Ichi Uchida, Tomohiro Ohkawa, Toru Futami, Koji Katayama, Kei Ichiro Nishizawa, Ken Ichiro Sotowa, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Lab on a Chip   4   159   2004.1

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    Erratum: Enzymatic degradation of p-chlorophenol in a two-phase flow microchannel system (Lab on a chip - Miniaturisation for Chemistry, Biology & Bioengineering (2003) 3 (308) (DOI: 10.1039/b309982b))

  • Rational design of a protein-based molecular device consisting of blue fluorescent protein and zinc protoporphyrin IX incorporated into a cytochrome b562 scaffold Reviewed

    Shuji Takeda, Noriho Kamiya, Teruyuki Nagamune

    Biotechnology Letters   26 ( 2 )   121 - 125   2004.1

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    DOI: 10.1023/B:BILE.0000012889.24412.ca

  • Properties of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix K1 Reviewed

    Hidehiko Hirakawa, Noriho Kamiya, Yutaka Kawarabayashi, Teruyuki Nagamune

    Journal of Bioscience and Bioengineering   97 ( 3 )   202 - 206   2004.1

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    DOI: 10.1263/jbb.97.202

  • Factors affecting the oxidative activity of laccase towards biphenyl derivatives in homogeneous aqueous-organic systems Reviewed

    Jo Tominaga, Junji Michizoe, Noriho Kamiya, Hirofumi Ichinose, Tatsuo Maruyama, Masahiro Goto

    Journal of Bioscience and Bioengineering   98 ( 1 )   14 - 19   2004.1

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    DOI: 10.1016/S1389-1723(04)70236-4

  • Enzymatic degradation of p-chlorophenol in a two-phase flow microchannel system Reviewed

    Tatsuo Maruyama, Jun Ichi Uchida, Tomohiro Ohkawa, Toru Futami, Koji Katayama, Kei Ichiro Nishizawa, Ken Ichiro Sotowa, Fukiko Kubota, Noriho Kamiya, Masahiro Goto

    Lab on a Chip   3 ( 4 )   308 - 312   2003.11

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    DOI: 10.1039/b309982b

  • Regioselective reduction of a steroid in a reversed micellar system with enzymatic NADH-regeneration

    H Hirakawa, N Kamiya, T Yata, T Nagamune

    BIOCHEMICAL ENGINEERING JOURNAL   16 ( 1 )   35 - 40   2003.10

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    DOI: 10.1016/S1369-703X(03)00019-6

  • ナノ集合体を利用した有機溶媒中におけるマンガンペルオキシダーゼの機能発現と環境汚染物質の分解 Reviewed

    道添純二, 小谷貴浩, 富永譲, 丸山 達生, 一瀬博文, 神谷典穂, 後藤雅宏

    膜 (Membrane)   28, 191-197   2003.10

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  • Site-specific cross-linking of functional proteins by transglutamination

    N Kamiya, T Takazawa, T Tanaka, H Ueda, T Nagamune

    ENZYME AND MICROBIAL TECHNOLOGY   33 ( 4 )   492 - 496   2003.9

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    DOI: 10.1016/S0141-0229(03)00154-6

  • Luminescent and substrate binding activities of firefly luciferase N-terminal domain Reviewed

    Tamotsu Zako, Keiichi Ayabe, Takahide Aburatani, Noriho Kamiya, Atsushi Kitayama, Hiroshi Ueda, Teruyuki Nagamune

    Biochimica et Biophysica Acta - Proteins and Proteomics   1649 ( 2 )   183 - 189   2003.7

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    DOI: 10.1016/S1570-9639(03)00179-1

  • Measuring adsorption of a hydrophobic probe with a surface plasmon resonance sensor to monitor conformational changes in immobilized proteins

    S Yamaguchi, T Mannen, T Zako, N Kamiya, T Nagamune

    BIOTECHNOLOGY PROGRESS   19 ( 4 )   1348 - 1354   2003.7

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    DOI: 10.1021/bp034015n

  • Luminescent and substrate binding activities of firefly luciferase N-terminal domain

    T Zako, K Ayabe, T Aburatani, N Kamiya, A Kitayama, H Ueda, T Nagamune

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   1649 ( 2 )   183 - 189   2003.7

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    DOI: 10.1016/S1570-9639(03)00179-1

  • Measuring adsorption of a hydrophobic probe with a surface plasmon resonance sensor to monitor conformational changes in immobilized proteins Reviewed

    Satoshi Yamaguchi, Teruhisa Mannen, Tamotsu Zako, Noriho Kamiya, Teruyuki Nagamune

    Biotechnology Progress   19 ( 4 )   1348 - 1354   2003.7

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    DOI: 10.1021/bp034015n

  • A novel protein-based heme sensor consisting of green fluorescent protein and apocytochrome b562 Reviewed

    Shuji Takeda, Noriho Kamiya, Teruyuki Nagamune

    Analytical Biochemistry   317 ( 1 )   116 - 119   2003.6

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    DOI: 10.1016/S0003-2697(03)00096-4

  • Controling the rate of protein release from polyelectrolyte complexes

    N Kamiya, AM Klibanov

    BIOTECHNOLOGY AND BIOENGINEERING   82 ( 5 )   590 - 594   2003.6

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    DOI: 10.1002/bit.10606

  • A novel protein-based heme sensor consisting of green fluorescent protein and apocytochrome b(562)

    S Takeda, N Kamiya, T Nagamune

    ANALYTICAL BIOCHEMISTRY   317 ( 1 )   116 - 119   2003.6

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    DOI: 10.1016/S-0003-2697(03)00096-4

  • Controling the rate of protein release from polyelectrolyte complexes Reviewed

    Noriho Kamiya, Alexander M. Klibanov

    Biotechnology and Bioengineering   82 ( 5 )   590 - 594   2003.6

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    DOI: 10.1002/bit.10606

  • Fabrication of a protein film by electrospray deposition method and investigation of photochemical properties by persistent spectral hole burning Reviewed

    Bumhwan Lee, Noriho Kamiya, Shinjiro Machida, Yutaka Yamagata, Kazuyuki Horie, Teruyuki Nagamune

    Biomaterials   24 ( 12 )   2045 - 2051   2003.5

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    DOI: 10.1016/S0142-9612(02)00637-3

  • Use of ionic liquids in a lipase-facilitated supported liquid membrane

    E Miyako, T Maruyama, N Kamiya, M Goto

    BIOTECHNOLOGY LETTERS   25 ( 10 )   805 - 808   2003.5

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    DOI: 10.1023/A:1023536922749

  • Fabrication of a protein film by electrospray deposition method and investigation of photochemical properties by persistent spectral hole burning

    B Lee, N Kamiya, S Machida, Y Yamagata, K Horie, T Nagamune

    BIOMATERIALS   24 ( 12 )   2045 - 2051   2003.5

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    DOI: 10.1016/S0142-9612(02)00637-3

  • Leakage mechanism of irinotecan from water-in-oil-in-water (W/O/W) multiple emulsions Reviewed

    Eiichi Toorisaka, Yuko Kokazu, Noriho Kamiya, Masahiro Goto

    kagaku kogaku ronbunshu   29 ( 2 )   294 - 298   2003.3

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    DOI: 10.1252/kakoronbunshu.29.294

  • S-peptide as a potent peptidyl linker for protein cross-linking by microbial transglutaminase from Streptomyces mobaraensis

    N Kamiya, T Tanaka, T Suzuki, T Takazawa, S Takeda, K Watanabe, T Nagamune

    BIOCONJUGATE CHEMISTRY   14 ( 2 )   351 - 357   2003.3

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    DOI: 10.1021/bc025610y

  • Ring-opening polymerization of lactones catalyzed by surfactant-coated lipases in organic solvents

    T Maruyama, S Noda, N Kamiya, M Goto

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN   36 ( 3 )   307 - 312   2003.3

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    DOI: 10.1252/jcej.36.307

  • S-peptide as a potent peptidyl linker for protein cross-linking by microbial transglutaminase from Streptomyces mobaraensis Reviewed

    Noriho Kamiya, Tsutomu Tanaka, Tsutomu Suzuki, Takeshi Takazawa, Shuji Takeda, Kimitsuna Watanabe, Teruyuki Nagamune

    Bioconjugate Chemistry   14 ( 2 )   351 - 357   2003.3

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    DOI: 10.1021/bc025610y

  • Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

    E Toorisaka, H Ono, K Arimori, N Kamiya, M Goto

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   252 ( 1-2 )   271 - 274   2003.2

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    DOI: 10.1016/S0378-5173(02)00674-9

  • Control of water content by reverse micellar solutions for peroxidase catalysis in a water-immiscible organic solvent Reviewed

    Junji Michizoe, Yoichi Uchimura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Journal of Bioscience and Bioengineering   95 ( 4 )   425 - 427   2003.1

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    DOI: 10.1263/jbb.95.425

  • Transport of Organic Acids through a Supported Liquid Membrane Driven by Lipase-Catalyzed Reactions Reviewed

    Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Journal of Bioscience and Bioengineering   96 ( 4 )   370 - 374   2003.1

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    DOI: 10.1263/jbb.96.370

  • ヘムを標的にしたセンサータンパク質の構築とヘム測定への応用 Reviewed

    武田 修治, 神谷 典穂, 新海 政重, 長棟 輝行

    生化学   74 ( 8 )   828 - 828   2002.8

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  • Self-assembly of electron transport protein using oligonucleotide hybridization Reviewed

    Masafumi Shimizu, Noriho Kamiya, Atsushi Kitayama, Teruyuki Nagamune

    Colloids and Surfaces B: Biointerfaces   25 ( 1 )   69 - 79   2002.3

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    DOI: 10.1016/S0927-7765(01)00305-8

  • Effect of water activity control on the catalytic performance of surfactant - Arthromyces ramosus peroxidase complex in toluene Reviewed

    Noriho Kamiya, Teruyuki Nagamune

    Biochemical Engineering Journal   10 ( 1 )   55 - 59   2002.2

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    DOI: 10.1016/S1369-703X(01)00162-0

  • Effect of water activity control on the catalytic performance of surfactant - Arthromyces ramosus peroxidase complex in toluene

    N Kamiya, T Nagamune

    BIOCHEMICAL ENGINEERING JOURNAL   10 ( 1 )   55 - 59   2002.2

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    DOI: 10.1016/S1369-703X(01)00162-0

  • Design of an artificial light-harvesting unit by protein engineering Cytochrome b562-green fluorescent protein chimera Reviewed

    Shuji Takeda, Noriho Kamiya, Ryoichi Arai, Teruyuki Nagamune

    Biochemical and Biophysical Research Communications   289 ( 1 )   299 - 304   2001.11

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    DOI: 10.1006/bbrc.2001.5966

  • Design of an artificial light-harvesting unit by protein engineering: Cytochrome b(562)-green fluorescent protein chimera

    S Takeda, N Kamiya, R Arai, T Nagamune

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   289 ( 1 )   299 - 304   2001.11

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    DOI: 10.1006/bbrc.2001.5966

  • Enhancement of apparent thermostability of lipase from Rhizopus sp by the treatment with a microbial transglutaminase

    N Kamiya, T Ogawa, T Nagamune

    BIOTECHNOLOGY LETTERS   23 ( 19 )   1629 - 1632   2001.10

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    DOI: 10.1023/A:1011936618341

  • 逆ミセル中における補酵素再生を伴う酸化還元反応に関する基礎的研究

    平川, 秀彦, 神谷, 典穂, 長棟, 輝行

    化学工学シンポジウムシリーズ76「高機能界面・分子集合体の基礎構築と応用分野の新展開」   - 133   2001.6

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  • How does heme axial ligand deletion affect the structure and the function of cytochrome b562? Reviewed

    Noriho Kamiya, Yuko Okimoto, Zhen Ding, Hiroko Ohtomo, Masafumi Shimizu, Atsushi Kitayama, Hisayuki Morii, Teruyuki Nagamune

    Protein Engineering   14 ( 6 )   415 - 419   2001.1

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    DOI: 10.1093/protein/14.6.415

  • Design of the linkers which effectively separate domains of a bifunctional fusion protein Reviewed

    R. Arai, H. Ueda, A. Kitayama, N. Kamiya, T. Nagamune

    Protein Engineering   14 ( 8 )   529 - 532   2001

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    DOI: 10.1093/protein/14.8.529

  • Enhancement of apparent thermostability of lipase from Rhizopus sp. by the treatment with a microbial transglutaminase Reviewed

    Noriho Kamiya, Takashi Ogawa, Teruyuki Nagamune

    Biotechnology Letters   23 ( 19 )   1629 - 1632   2001

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    DOI: 10.1023/A:1011936618341

  • Catalytic and structural properties of surfactant-horseradish peroxidase complex in organic media Reviewed

    Noriho Kamiya, Masahito Inoue, Masahiro Goto, Nobuhumi Nakamura, Yoshinori Naruta

    Biotechnology Progress   16 ( 1 )   52 - 58   2000.1

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    DOI: 10.1021/bp990125b

  • Catalytic and structural properties of surfactant-horseradish peroxidase complex in organic media

    N Kamiya, M Inoue, M Goto, N Nakamura, Y Naruta

    BIOTECHNOLOGY PROGRESS   16 ( 1 )   52 - 58   2000.1

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    DOI: 10.1021/bp990125b

  • Enantioselective recognition mechanism of secondary alcohol by surfactant-coated lipases in nonaqueous media Reviewed

    Noriho Kamiya, Hideaki Kasagi, Masahito Inoue, Koichiro Kusunoki, Masahiro Goto

    Biotechnology and Bioengineering   65 ( 2 )   227 - 232   1999.10

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    DOI: 10.1002/(SICI)1097-0290(19991020)65:2<227::AID-BIT14>3.0.CO;2-U

  • Enantioselective recognition mechanism of secondary alcohol by surfactant-coated lipases in nonaqueous media

    N Kamiya, H Kasagi, M Inoue, K Kusunoki, M Goto

    BIOTECHNOLOGY AND BIOENGINEERING   65 ( 2 )   227 - 232   1999.10

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    DOI: 10.1002/(SICI)1097-0290(19991020)65:2<227::AID-BIT14>3.0.CO;2-U

  • Surfactant-histidine-heme ternary complex as a simple artificial heme enzyme in organic media Reviewed

    Noriho Kamiya, Masahiro Goto, Shintaro Furusaki

    Biotechnology and Bioengineering   64 ( 4 )   502 - 506   1999.8

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    DOI: 10.1002/(SICI)1097-0290(19990820)64:4<502::AID-BIT13>3.0.CO;2-H

  • Surfactant-histidine-heme ternary complex as a simple artificial heme enzyme in organic media

    N Kamiya, M Goto, S Furusaki

    BIOTECHNOLOGY AND BIOENGINEERING   64 ( 4 )   502 - 506   1999.8

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    DOI: 10.1002/(SICI)1097-0290(19990820)64:4<502::AID-BIT13>3.0.CO;2-H

  • Catalytic properties of novel reversed micellar system on trans-esterification by α-chymotrypsin in organic media Reviewed

    2 ( 1 )   29 - 33   1998.1

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    Novel reversed micelles formulated by sodium dioleylphosphate (SDOLP) has been developed for enzymatic reaction in organic media. Comparison study between sodium bis-(2-ethylhexyl)-sulfosuccinate (Aerosol-OT or AOT) and SDOLP, which was carried out by investigating the reactivity of each reversed micellar system as reaction media for enzymatic transesterification reaction of N-acetyl-1-phenylalanine ethyl ester (APEE) and 1-propanol, leads to the upshot that α-chymotrypsin immobilized within SDOLP reversed micelles can persevere its high catalytic activity in isooctane. The initial reaction rate of the SDOLP reversed micellar system is almost 60 times higher than that in the AOT system. Additional kinetic results, including the Michaelis constant and the maximum reaction rate, reveal that the inner core of the SDOLP reversed micelles provides a better environment for enzymatic reaction than that of the conventional AOT reversed micelles.

    DOI: 10.1016/S1369-703X(98)00013-8

  • Preparation of surfactant-coated lipases utilizing the molecular imprinting technique Reviewed

    Noriho Kamiya, Masahiro Goto

    Journal of Fermentation and Bioengineering   85 ( 2 )   237 - 239   1998.1

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    DOI: 10.1016/S0922-338X(97)86774-8

  • Peroxidase activity and stability of surfactant-heme complex in nonaqueous media Reviewed

    N. Kamiya, S. Furusaki, M. Goto

    Biotechnology letters   19 ( 10 )   1015 - 1018   1997.11

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    DOI: 10.1023/A:1018403518763

  • Application of novel preparation method for surfactant-protease complexes catalytically active in organic media Reviewed

    Shin Ya Okazaki, Noriho Kamiya, Masahiro Goto

    Biotechnology Progress   13 ( 5 )   551 - 556   1997.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bp970064m

  • Application of novel preparation method for surfactant-protease complexes catalytically active in organic media

    S Okazaki, N Kamiya, M Goto

    BIOTECHNOLOGY PROGRESS   13 ( 5 )   551 - 556   1997.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bp970064m

  • Enantioselective esterification of glycidol by surfactant-lipase complexes in organic media Reviewed

    Shin Ya Okazaki, Noriho Kamiya, Masahiro Goto, Fumiyuki Nakashio

    Biotechnology letters   19 ( 6 )   541 - 543   1997.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1018337320213

  • Novel preparation method for surfactant-lipase complexes utilizing water in oil emulsions

    SY Okazaki, N Kamiya, K Abe, M Goto, F Nakashio

    BIOTECHNOLOGY AND BIOENGINEERING   55 ( 2 )   455 - 460   1997.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/(SICI)1097-0290(19970720)55:2<455::AID-BIT23>3.0.CO;2-E

  • How is enzymatic selectivity of menthol esterification catalyzed by surfactant-coated lipase determined in organic media?

    N Kamiya, M Goto

    BIOTECHNOLOGY PROGRESS   13 ( 4 )   488 - 492   1997.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bp9700317

  • Novel preparation method for surfactant-lipase complexes utilizing water in oil emulsions Reviewed

    Shin Ya Okazaki, Noriho Kamiya, Kojiro Abe, Masahiro Goto, Fumiyuki Nakashio

    Biotechnology and Bioengineering   55 ( 2 )   455 - 460   1997.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/(SICI)1097-0290(19970720)55:2<455::AID-BIT23>3.0.CO;2-E

  • How is enzymatic selectivity of menthol esterification catalyzed by surfactant-coated lipase determined in organic media? Reviewed

    Noriho Kamiya, Masahiro Goto

    Biotechnology Progress   13 ( 4 )   488 - 492   1997.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bp9700317

  • Enzymatic polymerization catalyzed by surfactant-coated lipases in organic media

    S Noda, N Kamiya, M Goto, F Nakashio

    BIOTECHNOLOGY LETTERS   19 ( 4 )   307 - 309   1997.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1018334430266

  • 有機溶媒中で高い酵素活性を発現させるには(2)有機溶媒不溶化酵素の利用

    神谷 典穂, 後藤 雅宏, 中塩 文行

    ケミカルエンジニヤリング   42 ( 3 )   222 - 226   1997.3

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    Language:Japanese  

  • Enzymatic polymerization catalyzed by surfactant-coated lipases in organic media Reviewed

    Sadafumi Noda, Noriho Kamiya, Masahiro Goto, Fumiyuki Nakashio

    Biotechnology letters   19 ( 4 )   307 - 310   1997.1