Updated on 2024/09/27

Information

 

写真a

 
KAWAGUCHI YOSHIROU
 
Organization
Faculty of Engineering Department of Applied Chemistry Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Tel
0928022808
Profile
経皮ワクチンに関する研究の推進、支援。 樹状細胞ターゲティングペプチドを用いた経皮ワクチンの高機能化検討。 指向性進化法に関する研究。
External link

Degree

  • Ph.D. Systems Life Sciences (Kyushu University)

Research History

  • 第一三共株式会社‐抗体および抗体様中分子を利用した創薬研究

    第一三共株式会社‐抗体および抗体様中分子を利用した創薬研究

Research Interests・Research Keywords

  • Research theme：Creation of Dendritic Cell-Targeting Peptides for Transdermal Cancer Vaccines

    Keyword：Transdermal Vaccines, Peptides, Protein Engineering, Directed Evolution

    Research period： 2023.11 - 2026.3

Papers

  • Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library Reviewed International journal

    Hidenori Yano, Daisuke Nishimiya, Yoshirou Kawaguchi, Masakazu Tamura, Ryuji Hashimoto

    PLoS One   2023.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172159

  • A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders Reviewed International journal

    Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani, Shinnosuke Tsuji, Kensuke Nakamura, Satoshi Ohte, Yoshiro Kawaguchi, Kiyosumi Takaishi

    Nature Communications   2023.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172165

  • A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases Reviewed International journal

    Daisuke Nishimiya, Yoshirou Kawaguchi, Shiho Kodama, Hatsumi Nasu, Hidenori Yano, Aya Yamaguchi, Masakazu Tamura, Ryuji Hashimoto

    Scientific Reports   2020.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7171754

  • Generation of efficient mutants of endoglycosidase from Streptococcus pyogenes and their application in a novel one-pot transglycosylation reaction for antibody modification Reviewed International journal

    Mitsuhiro Iwamoto, Yukiko Sekiguchi, Kensuke Nakamura, Yoshirou Kawaguchi, Takeshi Honda, Jun Hasegawa

    PLoS One   2018.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7171753

  • The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein Reviewed International journal

    Yoshirou Kawaguchi, Nobuo Sugiura, Koji Kimata, Makoto Kimura, Yoshimitu Kakuta

    FEBS Letters   2013.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172191

  • Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction Reviewed International journal

    Takamasa Teramoto, Yukari Fujikawa, Yoshirou Kawaguchi, Katsuhisa Kurogi, Masayuki Soejima, Rumi Adachi, Yuichi Nakanishi, Emi Mishiro-Sato, Ming-Cheh Liu, Yoichi Sakakibara, Masahito Suiko, Makoto Kimura, Yoshimitsu Kakuta

    Nature Communications   2013.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172241

  • Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66 Reviewed International journal

    Yoshirou Kawaguchi, Nobuo Sugiura, Momo Onishi, Koji Kimata, Makoto Kimura, Yoshimitu Kakuta

    Acta Crystallographica Section F   2011.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172192

  • Glucuronyltransferase activity of KfiC from Escherichia coli strain K5 requires association of KfiA: KfiC and KfiA are essential enzymes for production of K5 polysaccharide, N-acetylheparosan Reviewed International journal

    Nobuo Sugiura, Yuichi Baba, Yoshirou Kawaguchi, Toru Iwatani, Kiyoshi Suzuki, Takahiro Kusakabe, Kiwamu Yamagishi, Koji Kimata, Yoshimitsu Kakuta, Hideto Watanabe

    The Journal of Biological Chemistry   2010.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Repository Public URL： https://hdl.handle.net/2324/7172161

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Presentations

  • Crystal structure of human tyrosylprotein sulfotransferase International conference

    Yoshirou Kawaguchi, Takamasa Teramoto, Yukari Fujikawa, Katsuhisa Kurogi, Masayuki Soejima, Rumi Adachi, Yuichi Nakanishi, Emi Mishiro-Sato, Ming-Cheh Liu, Yoichi Sakakibara, Masahito Suiko, Makoto Kimura, Yoshimitsu Kakuta

    International Union of Crystallography  2011.8 

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    Event date： 2011.8

    Language：English  

    Country：Spain  

    Other Link： http://iucr2011.iucr.org/

Industrial property rights

Patent   Number of applications: 0   Number of registrations: 2
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Research Projects

  • バキュロウイルス由来新奇コンドロイチンリアーゼの立体構造解明と機能改変

    2013 - 2014

    日本学術振興会  特別研究員

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    Grant type：Joint research

Class subject

  • 応用化学実験第三

    2024.10 - 2025.3   Second semester

FD Participation

  • 2024.4   Role：Participation   Title：令和６年度 第１回全学FD（新任教員の研修）The 1st All-University FD (training for new faculty members) in FY2024

    Organizer：University-wide