Updated on 2025/04/24

Information

 

写真a

 
SASAKI SAORI
 
Organization
Faculty of Engineering Department of Mechanical Engineering Assistant Professor
School of Engineering （Concurrent）
Graduate School of Engineering Department of Mechanical Engineering（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0928023076
Homepage
External link

Research Areas

  • Nanotechnology/Materials / Polymer materials

  • Life Science / Biomaterials

  • Life Science / Biomedical engineering

Degree

  • Ph.D. Eng.

Research Interests・Research Keywords

  • Research theme： 高分子ゲル

    Keyword： 高分子ゲル

    Research period： 2024

  • Research theme： バイオメカニクス

    Keyword： バイオメカニクス

    Research period： 2024

  • Research theme： Biomaterial

    Keyword： Biomaterial

    Research period： 2024

  • Research theme： Elucidation of the mechanism of soft-domain-directed movement of cells induced by micro-topography of substrate surfaces

    Keyword： Cell Migration, Substrate Properties, Microconvex Structure

    Research period： 2020.4

  • Research theme： Biomimetic function of biocompatible polymer gel

    Keyword： Hydrogel Biomaterial

    Research period： 2019.2

  • Research theme： Elution behavior of non-crosslinked-polymer from physically cross-linked poly(vinyl alcohol) gel

    Keyword： poly(vinyl alcohol), physically cross-linked gel, elution

    Research period： 2012.4

Awards

  • IUMRS Award for Encouragement of Research in IUMRS−ICAM 2017

    2017.8   IUMRS   Effect of Gamma Ray Irradiation on Friction Property of PVA Hybrid Gel

Papers

  • The effect of stiff substrates on the collective migration of A549 cells Reviewed International journal

    Saori SASAKI, Zhaoyi DU, Ryu TAKAHASHI, Qi SUN, Toshihiro SERA, Susumu KUDO

    Journal of Biomechanical Science and Engineering   2023.9

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1299/jbse.23-00298

  • Spatiotemporal distribution of PKCα, Cdc42, and Rac1 before directed cell migration Reviewed International journal

    Saori Sasaki, Ryu Takahashi, Yangfeng Luo, Kengo Chujo, Toshihiro Sera and Susumu Kudo

    Biochemical and Biophysical Research Communications   584   26 - 31   2021.12

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2021.10.080

  • Precise design of microwrinkles through the independent regulation of elasticity on the surface and in the bulk of soft hydrogels Reviewed

    Saori Sasaki, Satoru Kidoaki

    Polymer Journal   52 ( 5 )   515 - 522   2020.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41428-019-0299-8

  • Mechanisms of endothelial cell coverage by pericytes computational modelling of cell wrapping and in vitro experiments Reviewed

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, Takashi Miura

    Journal of the Royal Society, Interface   17 ( 162 )   2020.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1098/rsif.2019.0739

  • Effect of Drying on the Frictional Properties of PVA Cast Gel Reviewed

    Saori Sasaki, Seido Yarimitsu, Teruo Murakami, Atsushi Suzuki, Kobunshi Ronbunshu

    KOBUNSHI RONBUNSHU   73 ( 2 )   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1295/koron.2015-0036er

  • Frictional properties of physically cross-linked PVA hydrogels as artificial cartilage Reviewed

    S. Sasaki, T. Murakami, A. Suzuki

    Biosurface and Biotribology   2 ( 1 )   11 - 17   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bsbt.2016.02.002

  • Evaluation of lubrication properties of hydrogel artificial cartilage materials for joint prosthesis Reviewed

    S. Yarimitsu, S. Sasaki, T. Murakami, A. Suzuki

    Biosurface and Biotribology   2 ( 1 )   40 - 47   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bsbt.2016.02.005

  • Factors influencing the swelling and elution properties of poly(vinyl alcohol) cast gels Reviewed

    Saori Sasaki, Atsushi Suzuki

    Polymers for Advanced Technologies   27 ( 3 )   318 - 324   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/pat.3643

  • A Novel Method to Control the Elution Behavior of PVA Cast Gels Reviewed

    Saori Sasaki, Atsushi Suzuki

    Macromolecular Symposia   358 ( 1 )   170 - 175   2015.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/masy.201500058

  • Swelling and mechanical properties of physically crosslinked poly(vinyl alcohol) hydrogels Reviewed

    Atsushi Suzuki, Saori Sasaki

    Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine   229 ( 12 )   828 - 844   2015.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/0954411915615469

  • Effect of drying on the frictional properties of PVA cast gel Reviewed

    Saori Sasaki, Seido Yarimitsu, Teruo Murakami, Atsushi Suzuki

    KOBUNSHI RONBUNSHU   72 ( 12 )   760 - 764   2015.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1295/koron.2015-0036

  • Change in molecular weight distribution by elution of polymers from PVA cast gel Reviewed

    Saori Sasaki, Atsushi Suzuki

    Polymer Bulletin   71 ( 9 )   2383 - 2394   2014.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00289-014-1196-0

  • Effects of repeated water exchange and the molecular-weight distribution of PVA cast gels on the elution of polymers Reviewed

    Saori Sasaki, Atsushi Suzuki

    Reactive and Functional Polymers   73 ( 7 )   878 - 884   2013.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.reactfunctpolym.2013.01.010

  • Elution of polymers from poly(vinyl alcohol) cast gels with different degrees of polymerization and hydrolysis Reviewed

    Saori Sasaki, Emiko Otsuka, Yumiko Hirashima, Atsushi Suzuki

    Journal of Applied Polymer Science   126 ( SUPPL. 2 )   2012.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/app.36919

  • Elution of polymers from physically cross-linked poly(vinyl alcohol) gels Reviewed

    Emiko Otsuka, Saori Sasaki, Kenta Koizumi, Yumiko Hirashima, Atsushi Suzuki

    Soft Matter   6 ( 24 )   6155 - 6159   2010.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/c0sm00757a

  • Spatiotemporal distribution of PKCα, PIP3, Moesin, Cdc42, MARCKS, Scriblle, and Arf6 before directed cell migration in monolayers

    Quanzhi Lu, Katsuyuki Ushijima, Saori Sasaki, Toshihiro Sera, Naoki Takeishi, Susumu Kudo

    Biochemical and Biophysical Research Communications   750   151371 - 151371   2025.3   （ ISSN:0006-291X eISSN:1090-2104 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Protein kinase Cα (PKCα) has an important role in directed cell migration. After a mechanical wounding, PKCα rapidly accumulates at cell edges adjacent to the wounded cell and regulates cell migration. However, the proteins downstream of PKCα that mediate directed signaling remain unknown. In this study, we examined the spatiotemporal dynamics of PKCα, PIP3, Moesin, Cdc42, MARCKS, Scribble, and Arf6 before directed migration. After wounding, PIP3, Moesin, and Cdc42 accumulated at the cell edge near the wounded cells later than PKCα. In contrast, MARCKS moved away from the plasma membrane without polarization, and Scribble and Arf6 exhibited no significant translocation. The inhibition of PIP3 suppressed the accumulation of Moesin and Cdc42, suggesting that PIP3 regulates Moesin and Cdc42. In particular, the inhibition of PKCα completely inhibited the translocation of all factors, indicating that PKCα is a central regulator in early signaling after wounding and before directional migration.

    DOI： 10.1016/j.bbrc.2025.151371

    Web of Science

    Scopus

    PubMed

    researchmap

  • Overstretching alveolar epithelial type II cells decreases surfactant secretion via actin polymerization and intracellular trafficking alteration. Reviewed International journal

    Shigesato Inoue, Junpei Nagao, Kouhei Kawamoto, Keiko Kan-O, Satoru Fukuyama, Saori Sasaki, Susumu Kudo, Isamu Okamoto, Toshihiro Sera

    Heliyon   10 ( 13 )   e33499   2024.7   （ ISSN:24058440 eISSN:2405-8440 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Heliyon  

    Pulmonary surfactant is essential for maintaining proper lung function. Alveolar epithelial type II (AE2) cells secrete surfactants via lamellar bodies (LBs). In tidal loading during each breath, the physiological cyclic stretching of AE2 cells promotes surfactant secretion. Excessive stretching inhibits surfactant secretion, which is considered to contribute to the development of lung damage. However, its precise mechanism remains unknown. This study tested whether actin polymerization and intracellular transport are required for pulmonary surfactant secretion and the association of actin polymerization and transport in identical human AE2-derived A549 cells using live-cell imaging, not in the bulk cells population. We found that overstretching approximately doubled actin polymerization into filaments (F-actin) and suppressed LB secretion by half in the fluorescent area ratio, compared with physiological stretching (F-actin: 1.495 vs 0.643 (P < 0.01); LB: 0.739 vs 0.332 (P < 0.01)). An inhibitor of actin polymerization increased LB secretion. Intracellular tracking using fluorescent particles revealed that cyclic stretching shifted the particle motion perpendicularly to the direction of stretching according to the orientation of the F-actin (proportion of perpendicular axis motion prior particle: 0h 40.12 % vs 2h 63.13 % (P < 0.01)), and particle motion was restricted over time in the cells subjected to overstretching, indicating that overstretching regulates intracellular transport dynamics (proportion of stop motion particle: 0h 1.01 % vs 2h 11.04 % (P < 0.01)). These findings suggest that overstretching changes secretion through the cytoskeleton: overstretching AE2 cells inhibits pulmonary surfactant secretion, at least through accelerating actin polymerization and decreasing intracellular trafficking, and the change in actin orientation would modulate intracellular trafficking.

    DOI： 10.1016/j.heliyon.2024.e33499

    Web of Science

    Scopus

    PubMed

    researchmap

  • Spatiotemporal distribution of PTEN before directed cell migration in monolayers Reviewed

    Quanzhi Lu, Saori Sasaki, Toshihiro Sera, Susumu Kudo

    In Vitro Cellular &amp; Developmental Biology - Animal   60 ( 10 )   1160 - 1173   2024.6   （ ISSN:1071-2690 eISSN:1543-706X ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    The intracellular distribution of phosphatase and tensin homolog (PTEN) is closely related to directed cell migration. In single cells, PTEN accumulates at the rear of the cell before and during directed migration; however, the spatiotemporal distribution of PTEN in confluent cell monolayers, particularly before directed migration, remains unclear. In this study, we wounded a cell in confluent fetal rat skin keratinocytes (FRSKs) and examined the dynamics of PTEN in the cells adjacent to the wounded cell. In contrast to single-cell migration, we found that PTEN translocated to the nucleus before the beginning of directed migration. This nuclear translocation of PTEN did not occur in disconnected cells, and it was also suppressed by importin-β inhibitor and actin inhibitor. When the nuclear localization of PTEN was inhibited by an importin-β inhibitor, cell elongation in the direction of migration was also significantly inhibited. Our results indicate that PTEN translocation is induced by the disruption of cell–cell adhesion and requires the involvement of importin-β and actin cytoskeleton signaling. In addition, phosphatidylinositol 3,4,5-triphosphate (PIP3) may regulate PTEN distribution through its localized accumulation at the cell edge. Our findings suggest that the translocation of PTEN is crucial for directed cell migration and for responding to mechanical environmental changes in confluent cell monolayers.

    DOI： 10.1007/s11626-024-00927-x

    Web of Science

    Scopus

    PubMed

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s11626-024-00927-x/fulltext.html

  • Microscale unorganized wrinkle topographies on biomaterial surfaces modulate cell migration

    Sasaki Saori, Eguchi Keita, Wei Ming, Takahashi Ryu, Sera Toshihiro, Takeishi Naoki, Kudo Susumu

    Journal of Biorheology   38 ( 2 )   120 - 125   2024   （ ISSN:18670466 eISSN:18670474 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY OF BIORHEOLOGY  

    <p>Directional migration of eukaryotic cells results from an interplay between cell motility and environmental cues such as stiffness, roughness, and microtopological features of substrates. While the effects of aligned grooves on the substrate lithographically designed on active cell migration are well documented, the impact of unorganized and wrinkled substrates remains poorly understood. We investigated how microscale wrinkles on gelatin substrates regulate two-dimensional (2D) migration of immortalized human mesenchymal stem cells (iMSCs). We showed that there exists an optimal wrinkle size to enhance iMSC migration, where the iMSCs exhibited larger travel distance with moderate wrinkle size (30 μm) than shorter or larger wrinkle sizes (10 μm and 50 μm). These findings reveal a size-dependent effect of wrinkles on iMSC migration and provide insights into designing biomaterials to control stem cell behavior in regenerative medicine applications.</p>

    DOI： 10.17106/jbr.38.120

    Scopus

    CiNii Research

    researchmap

  • Quantification of membrane protein diffusion on endothelial cell surfaces under shear stress using a photochromic fluorescent protein

    Kawasaki Naoto, Hamasaki Keita, Sasaki Saori, Takeishi Naoki, Kudo Susumu

    Journal of Biorheology   38 ( 2 )   88 - 93   2024   （ ISSN:18670466 eISSN:18670474 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY OF BIORHEOLOGY  

    <p>The fluidity of endothelial cell (EC) membranes, consisting of a lipid bilayer and heterogeneous multicomponent, undergoes alterations in response to shear stress. Although localized variations in membrane fluidity are assumed to induce region-specific signal transduction by modulating membrane protein dynamics on almost planar bilayers, membrane protein diffusion under shear stress remains uncertain. Hence, this study aimed to quantify membrane protein diffusion on ECs under fluid shear stress. We used the photochromic fluorescent protein Dronpa to tag a glycosylphosphatidylinositol-anchored protein (GPI-AP), which diffuses across the outer membranes, and quantified its surface diffusion based on the spatiotemporal distribution of Dronpa-Green-labeled GPI-AP (DGGPI-AP) on EC membranes. We developed an experimental platform to measure the GPI-AP surface diffusion under fluid shear stress and quantified the diffusion coefficient of GPI-AP in two distinct membrane regions: upstream and downstream relative to the direction of fluid flow. Our experimental results showed that there were not statistically significant differences in GPI-AP diffusion on EC membranes between the time points or between the upstream and downstream regions of ECs for at least 15 minutes under shear stress. Our developed methodology and experimental results will be useful to understand a relationship between the membrane protein diffusion and shear-induced cellular processes.</p>

    DOI： 10.17106/jbr.38.88

    Scopus

    CiNii Research

    researchmap

  • がん細胞A549の集団遊走に及ぼす細胞接着基材の影響

    佐々木 沙織, 髙橋 周大, 工藤 奨

    Transactions of Japanese Society for Medical and Biological Engineering   Annual62 ( Abstract )   132_1 - 132_1   2024   （ ISSN:1347443X eISSN:18814379 ）

    　More details

    Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

    <p>がん細胞は生体内において接着環境の弾性率を上げてしまうことはよく知られている。そのため、がん組織は正常な組織と比較して硬い構造を有しており、乳がんの触診はこの特性を応用した簡便ながん診断法である。正常肺組織のヤング率は1〜5kPaであるのに対し、線維化組織や肺腫瘍組織は30倍程度硬い。しかしながら、肺は微視的には様々な組織から構成されており、腫瘍中のがん細胞は浸潤の際に硬いコラーゲン含有繊維に接触する。</p><p>本研究では、ヒト肺胞基底上皮腺癌細胞A549の集団遊走挙動に及ぼす基材弾性率の影響を調べた。架橋剤の比率を調整することにより弾性率の異なる（1.4、3.4、18.3MPa）ポリジメチルシロキサン（PDMS）基板を作製し、スクラッチアッセイにより、PDMS基板上および7.7 GPaガラス上でのA549細胞の遊走距離と遊走軌跡を調べた。その結果、A549細胞の18.3MPaでの移動範囲は、1.4MPaおよび3.4MPaでの移動範囲よりも有意に高かった。当日は細胞遊走の直進性についても併せて検討する。</p>

    DOI： 10.11239/jsmbe.annual62.132_1

    CiNii Research

  • 脳皮質中の刺激されたニューロンの近くにある細動脈の径に対する酸素濃度の影響(Effect of O2 concentration on arteriole diameter near stimulated neurons in the cortex)

    Sato Tatsuya, Sasaki Saori, Sera Toshihiro, Kudo Susumu

    Journal of Biorheology   37 ( 1 )   9 - 12   2023.8   （ ISSN:1867-0466 ）

    　More details

    Language：English   Publisher：(NPO)日本バイオレオロジー学会  

    脳皮質スライス標本を材料に、ニューロンを刺激することでその近傍の細動脈にみられる反応が、酸素濃度によってどのように変化するか実験した。3～4週齢の雄性Wistarラット16匹から脳皮質スライス標本を調製した。その培養液中の酸素濃度は20～95%の範囲で変化させた。脳皮質中のII/III層の錐体細胞を同定し、記録電極をその錐体細胞内に、刺激電極をIV層に設置した。トレイン刺激(20Hz、350ms)を0.75Hz周期で5回繰り返すことで興奮性シナプス後場電位を惹起させた。その結果、酸素濃度を95%に保った場合、錐体細胞を刺激することでその近傍における細動脈の径は縮小することが判明した。それと同条件で酸素濃度のみ20%とした時には、逆に細動脈径は拡張した。以上から、海馬のニューロンについて既に報告されていたのと同様に、皮質ニューロンでも近傍血管の反応の方向性は酸素濃度によって逆転することが示唆された。

  • Effect of O2 concentration on arteriole diameter near stimulated neurons in the cortex Invited Reviewed International journal

    @Tatsuya SATO, @Saori SASAKI, @Toshihiro SERA, and @Susumu KUDO

    Journal of Biorheology   accepted   accepted - accepted   2023.1

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • The effect of stiff substrates on the collective migration of A549 cells

    SASAKI Saori, DU Zhaoyi, TAKAHASHI Ryu, SUN Qi, SERA Toshihiro, KUDO Susumu

    Journal of Biomechanical Science and Engineering   18 ( 4 )   23-00298 - 23-00298   2023   （ ISSN:18809863 eISSN:18809863 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japan Society of Mechanical Engineers  

    <p>The Young’s modulus of normal lung tissues ranges from 1 to 5 kPa, whereas fibrotic or lung tumor tissues can be ~30 times stiffer. However, the lung parenchyma microscopically consists of various tissues, and cancer cells in tumors contact stiff collagen-containing fibers during invasion. In this study, we investigated the effect of stiff substrates on A549 cell migration. We fabricated stiff polydimethylsiloxane (PDMS) substrates with different stiffness levels (1.4, 3.4, and 18.3 MPa) by adjusting the cross-linking agent ratio. We examined the distance and the trajectory orientation of A549 cell migration on PDMS substrates and much stiffer 7.7 GPa glass with scratch-wound assays. A549 cells exhibited a collective sheet-like migration pattern toward the wounded area on stiff substrates. The migration range at 18.3 MPa was significantly higher than at 1.4 and 3.4 MPa, and that on glass was significantly higher than that at 18.3 MPa. The cell trajectory orientation on stiff PDMS substrates gradually increased and became constant, whereas that on glass was constant from the initial migration. Our results revealed that stiff substrates affect A549 cells migration in this range.</p>

    DOI： 10.1299/jbse.23-00298

    Scopus

    CiNii Research

    researchmap

  • Effect of O<sub>2</sub> concentration on arteriole diameter near stimulated neurons in the cortex

    Sato Tatsuya, Sasaki Saori, Sera Toshihiro, Kudo Susumu

    Journal of Biorheology   37 ( 1 )   9 - 12   2023   （ ISSN:18670466 eISSN:18670474 ）

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY OF BIORHEOLOGY  

    <p>The brain requires O<sub>2</sub> and nutrition to keep functioning. It is known that O<sub>2</sub> concentration converts the polarity of vessel response near the activated neuron in the hippocampus. However, it remains unclear whether O<sub>2</sub> concentration converts the polarity in the cortex. We investigated the comparison of the arteriole response near the stimulated neurons in cerebral cortex slices between 95% and 20% O<sub>2</sub> concentration in medium. We showed that the diameter of the blood vessels decreased under 95% O<sub>2</sub> concentration when the pyramidal cells near the blood vessels were stimulated and increased under 20% O<sub>2</sub> concentration with the same stimulation.</p>

    DOI： 10.17106/jbr.37.9

    Scopus

    CiNii Research

    researchmap

  • Nuclear activation in dual-durotaxing cells on a matrix with cell-scale stiffness-heterogeneity

    Satoru Kidoaki, Hiroyuki Ebata, Kosuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Rumi Sawada, Saori Sasaki, Tatsuya Okuda, Kosuke Hamano, Takahito Kawano, Aki Yamamoto, Ken Kono, Kazusa Tanaka

    2022.4

    　More details

  • Relationship between PKCα and MARCKS after adjacent cell are damaged

    USHIJIMA Katsuyuki, SASAKI Saori, SERA Toshihiro, KUDO Susumu

    The Proceedings of the JSME Conference on Frontiers in Bioengineering   2022.32 ( 0 )   1A32   2022   （ eISSN:24242810 ）

    　More details

    Language：Japanese   Publisher：The Japan Society of Mechanical Engineers  

    DOI： 10.1299/jsmebiofro.2022.32.1a32

    CiNii Research

  • Relationship between the elastic modulus of the substrate and PKCα accumulation due to adjacent cell detachment

    TAKAHASHI Ryu, SASAKI Saori, SERA Toshihiro, KUDO Susumu

    The Proceedings of the JSME Conference on Frontiers in Bioengineering   2022.32 ( 0 )   1A27   2022   （ eISSN:24242810 ）

    　More details

    Language：Japanese   Publisher：The Japan Society of Mechanical Engineers  

    DOI： 10.1299/jsmebiofro.2022.32.1a27

    CiNii Research

  • Response of PKCα and DAG during cell deformation

    KITAGAWA Tomoaki, SASAKI Saori, SERA Toshihiro, KUDO Susumu

    The Proceedings of the JSME Conference on Frontiers in Bioengineering   2022.32 ( 0 )   2A14   2022   （ eISSN:24242810 ）

    　More details

    Language：Japanese   Publisher：The Japan Society of Mechanical Engineers  

    DOI： 10.1299/jsmebiofro.2022.32.2a14

    CiNii Research

  • Cytoskeleton and cytoplasmic in type II alveolar cells during extension loading

    NAGAO Junpei, SASAKI Saori, SERA Toshihiro, KUDO Susumu

    The Proceedings of the JSME Conference on Frontiers in Bioengineering   2022.32 ( 0 )   2A17   2022   （ eISSN:24242810 ）

    　More details

    Language：Japanese   Publisher：The Japan Society of Mechanical Engineers  

    DOI： 10.1299/jsmebiofro.2022.32.2a17

    CiNii Research

  • Adhesive-ligand-independent cell-shaping controlled by the lateral deformability of a condensed polymer matrix Invited Reviewed International journal

    Sayaka Masaike, Saori Sasaki, Hiroyuki Ebata, Kosuke Moriyama, Satoru Kidoaki

    POLYMER JOURNAL   54 ( 2 )   211 - 222   2021.11   （ ISSN:0032-3896 eISSN:1349-0540 ）

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Polymer Journal  

    Cell adhesion on biomaterial surfaces has been extensively studied from the perspective of the adsorption properties of adhesive ligands, while recent research on mechanobiology has been revealing a critical role of the mechanical properties of the extracellular milieu in the control of cell adhesion, such as the stiffness and viscoelasticity of the matrix. Although the effects of the lateral mobility of an adhesive ligand have been intensively investigated in a model substrate with water-soluble polymer layers, less is known about those in the setting of lateral deformability of hydrophobic condensed polymer layers. In this study, to help clarify this issue, we used PNIPAAm-grafted substrates with a well-controlled degree of graft-polymerization (DGP) as a typical hydrophobic condensed polymer surface at a cell culture temperature of 37 °C. We observed a clear negative correlation between cell spreading and DGP of PNIPAAm regardless of the amount of fibronectin adsorbed on the substrates, which was found to be attributable to the lateral deformability of a condensed PNIPAAm layer based on lateral force microscopic analysis. The surface-lateral-deformation-induced modulation in stability and maturation of focal adhesion of the cells is discussed in relation to the matrix-strain-induced alteration of the density distribution of adsorbed adhesive ligands.

    DOI： 10.1038/s41428-021-00577-w

    Web of Science

    Scopus

  • A metabolic reaction–diffusion model for PKCα translocation via PIP2 hydrolysis in an endothelial cell Reviewed International journal

    Toshihiro Sera; Shiro Higa; Yan Zeshu; Kyosuke Takahi; Satoshi Miyamoto; Tetsuya Fujiwara; Hideo Yokota; Saori Sasaki; Susumu Kudo

    Biochemical Journal   2020.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1042/BCJ20200484

  • Lipid membrane effect on the elasticity of gelatin microgel prepared inside lipid microdroplets Reviewed

    Atsushi Sakai, Naomi Hiro-oka, Saori Sasaki, Satoru Kidoaki, Miho Yanagisawa

    Nihon Reoroji Gakkaishi   47 ( 2 )   55 - 59   2019.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1678/rheology.47.55

  • Persistent random deformation model of cells crawling on a gel surface Reviewed

    Hiroyuki Ebata, Aki Yamamoto, Yukie Tsuji, Saori Sasaki, Kousuke Moriyama, Thasaneeya Kuboki, Satoru Kidoaki

    Scientific reports   8 ( 1 )   2018.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-018-23540-x

  • Increasing Elasticity through Changes in the Secondary Structure of Gelatin by Gelation in a Microsized Lipid Space Reviewed

    Atsushi Sakai, Yoshihiro Murayama, Kei Fujiwara, Takahiro Fujisawa, Saori Sasaki, Satoru Kidoaki, Miho Yanagisawa

    ACS Central Science   4 ( 4 )   477 - 483   2018.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acscentsci.7b00625

  • Effect of Gamma Ray Irradiation on Friction Property of Poly(vinyl alcohol) Cast-Drying on Freeze-Thawed Hybrid Gel Reviewed International journal

    Saori Sasaki, Seiji Omata, Teruo Murakami, Naotsugu Nagasawa, Mitsumasa Taguchi, Atsushi Suzuki

    Gels   2018.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Development of PVA Hydrogels with Superior Lubricity for Artificial Cartilage

    Atsushi Suzuki, Saori Sasaki, Teruo Murakami

    Rheology of Biological Soft Matter: Fundamentals and Applications   339 - 374   2017.11

    　More details

    Language：English  

    DOI： 10.1007/978-4-431-56080-7_13

  • Characterization of the Frustrated Differentiation of Mesenchymal Stem Cells Induced by Normadic Migration Between Stiff and Soft Region of Gel Matrix

    Satoru Kidoaki, Hiroyuki Ebata, Rumi Sawada, Kousuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Ken Kono, Kazusa Tanaka, Saori Sasaki

    Biophysical Journal   112 ( 3, Supplement 1 )   436a   2017

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bpj.2016.11.2328

  • Evaluation of lubrication property of poly(vinyl alcohol) hybrid gel for artificial articular cartilage Reviewed

    Seido Yarimitsu, Ayumi Yoshida, Saori Sasaki, Teruo Murakami, Atsushi Suzuki

    Tribology Online   11 ( 2 )   360 - 365   2016.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2474/trol.11.360

  • Tear force of physically crosslinked poly(vinyl alcohol) gels with different submicrometer-scale network structures Reviewed

    Taegu Noh, Yujiro Bando, Kensuke Ota, Saori Sasaki, Atsushi Suzuki

    Journal of Applied Polymer Science   132 ( 4 )   2015.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/app.41356

  • Elution and wear of PVA hydrogels by reciprocating friction

    Atsushi Suzuki, Saori Sasaki, Syouhei Sasaki, Taegu Noh, Kazuhiro Nakashima, Seido Yarimitsu, Teruo Murakami

    5th World Tribology Congress, WTC 2013   2283 - 2286   2014.1

    　More details

    Language：English   Publishing type：Research paper (other academic)  

  • Effects of preparation temperature on swelling and mechanical properties of PVA cast gels Reviewed

    Emiko Otsuka, Shin Komiya, Saori Sasaki, Jiawen Xing, Yujiro Bando, Yumiko Hirashima, Masaaki Sugiyama, Atsushi Suzuki

    Soft Matter   8 ( 31 )   8129 - 8136   2012.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/c2sm25513h

▼display all

Books

  • Development of PVA Hydrogels with Superior Lubricity for Artificial Cartilage

    Atsushi Suzuki, Saori Sasaki, Teruo Murakami

    Springer Japan  2017.1 

    　More details

    Responsible for pages：339-374   Language：English  

    Physically cross-linked poly(vinyl alcohol) (PVA) gels are versatile biomaterials with their excellent biocompatibility and mechanical strength. Since the late 1970s, the semicrystalline PVA gels prepared by a freeze-thawing method (FT gel) have been extensively studied in characterizing the structural and functional properties for practical applications, such as artificial hydrogel cartilage. Recently, a simple preparation method for a physically cross-linked PVA gel by a cast-drying method (CD gel) was reported. Although the network nanostructures are similar, CD gels are transparent and elastic, while FT gels are opaque and less elastic. The crystallization conditions of these systems have been investigated; the gels become highly swollen and rigid by the selection of optimum preparation conditions. In this chapter, the mechanical properties of FT and CD gels, such as tearing energy, sliding friction, and abrasion loss, are reviewed in connection with the nano- and microstructures of physical PVA gels. The tribological properties of FT and CD gels are compared with that of natural cartilage. Based on experimental results, simple preparation methods to improve the mechanical and lubrication properties of physically cross-linked PVA gels are presented, and the mechanism of superior lubricity in newly developed PVA gels for artificial hydrogel cartilage is discussed.

    DOI： 10.1007/978-4-431-56080-7_13

  • Elution and wear of PVA hydrogels by reciprocating friction

    Atsushi Suzuki, Saon Sasaki, Syouhei Sasaki, Taegu Noh, Kazuhiro Nakashima, Seido Yarimitsu, Teruo Murakami

    Politecnico di Torino (DIMEAS)  2014.1 

    　More details

    Responsible for pages：2283-2286   Language：English  

Presentations

  • 細胞接着面の基材弾性率と隣接細胞剥離に伴う細胞内PKCα集積の関係について

    高橋龍, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第32回バイオフロンティア講演会  2022.1 

    　More details

    Event date： 2022.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Development of gelatin gels for cell culture with controllable surface microwrinkles International conference

    Saori Sasaki, Keita Eguchi, Ming Wei, Ryu Takahashi, Toshihiro Sera, Susumu Kudo

    Materials Research Meeting 2021 (MRM2021)  2021.12 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：パシフィコ横浜ノース   Country：Japan  

  • Cell Migration on gelatin gels with controllable surface microwrinkle International conference

    Saori Sasaki, Keita Eguchi, Ming Wei, Ryu Takahashi, Toshihiro Sera, Susumu Kudo

    11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)  2021.12 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 表面微細凹凸構造の制御可能な細胞培養ゼラチンゲルの開発

    佐々木 沙織, 江口 慶太, 魏 銘, 高橋 龍, 世良 俊博, 工藤 奨

    高分子学会 第70回高分子討論会  2021.9 

    　More details

    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 細胞培養基材ハイドロゲルの機械的特性が細胞遊走に及ぼす影響

    佐々木沙織、杜兆宜、江口慶太、孫琪、世良俊博、工藤奨

    日本バイオレオロジー学会 第44回日本バイオレオロジー学会年会  2021.7 

    　More details

    Event date： 2021.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • ゼラチンを用いた細胞培養基質の開発

    江口慶太, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会九州支部第52会学生員卒業研究発表講演会  2021.3 

    　More details

    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • 細胞培養ゲル上への微細凹凸構造導入と遊走に及ぼす影響

    佐々木沙織，江口慶太，高橋 龍，世良俊博，工藤 奨

    日本バイオマテリアル学会 ２０２０年度九州ブロック学術講演会  2021.1 

    　More details

    Event date： 2021.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 生体模倣材料としての高分子ゲル Invited

    佐々木沙織

    日本レオロジー学会第67回レオロジー討論会 バイオレオロジーフォーラム  2019.10 

    　More details

    Event date： 2019.11

    Language：Japanese  

    Country：Japan  

  • 細胞培養・観察を目的としたゼラチンゲルの不溶化

    佐々木沙織、世良俊博、工藤奨

    高分子学会 第71回高分子討論会  2022.9 

    　More details

    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Keratin 構造の違いによる PKCα 局在への影響

    森岡真悠, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 細胞変形時のRab11とCaveolin-1の挙動

    尾﨑郁美, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 細胞間張力の消失によるPIP3とPTENの局在

    盧泉至, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 力学場変化時のPKCαの応答解析

    北川智晃, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 隣接細胞損傷時における細胞骨格がYAP動態に及ぼす影響について

    肖博元, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 隣接細胞損傷時の細胞内PKCαトランスロケーションとMARCKSの関係

    牛島克恭, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • PKCの構造が隣接細胞剥離によるトランスロケーションに及ぼす影響

    小野瀬孝一, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第34回バイオエンジニアリング講演会  2022.6 

    　More details

    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 細胞変形による細胞質流動と細胞内タンパク質の関係

    大兼健史，佐々木沙織，世良俊博，工藤奨

    日本機械学会九州支部 第75期総会・講演会  2022.3 

    　More details

    Event date： 2022.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 伸展負荷時におけるⅡ型肺胞細胞内の細胞骨格と細胞質

    長尾淳平, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第32回バイオフロンティア講演会  2022.1 

    　More details

    Event date： 2022.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 隣接細胞損傷時の細胞内タンパク質PKCαとMARCKSの関係

    牛島克恭, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第32回バイオフロンティア講演会  2022.1 

    　More details

    Event date： 2022.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 細胞変形時におけるPKCαとDAGの応答

    北川智晃, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会 第32回バイオフロンティア講演会  2022.1 

    　More details

    Event date： 2022.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • YAP dynamics during adjacent cell injury International conference

    Boyuan XIAO, Saori SASAKI, Toshihiro SERA, Susumu KUDO

    11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)  2021.12 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Relative behavior of PIP3 and PTEN caused by disconnection between cells International conference

    QUANZHI LU, Saori SASAKI, Toshihiro SERA, Susumu KUDO

    11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)  2021.12 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 力学刺激下における細胞膜近傍物質の移動現象

    工藤 奨、世良 俊博、佐々木 沙織

    日本機械学会 第33回バイオエンジニアリング講演会  2021.6 

    　More details

    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 隣接細胞剥離時のPKCα応答と細胞内変形の同時計測

    北川 智晃、佐々木 沙織、世良 俊博、工藤 奨

    日本機械学会 第33回バイオエンジニアリング講演会  2021.6 

    　More details

    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • コラーゲン薄膜を用いた共培養システムの検討

    藤田芳孝, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会九州支部第52会学生員卒業研究発表講演会  2021.3 

    　More details

    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • 隣接細胞剥離時の細胞内ひずみの計測

    北川智晃, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会九州支部第52会学生員卒業研究発表講演会  2021.3 

    　More details

    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • 隣接細胞損傷時のMARCKSの挙動

    牛島克恭, 佐々木沙織, 世良俊博, 工藤奨

    日本機械学会九州支部第52会学生員卒業研究発表講演会  2021.3 

    　More details

    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • ゼラチンゲルを用いた弾性細胞培養デバイスの作製

    佐々木 沙織, 高橋 龍, 世良 俊博, 工藤 奨

    日本機械学会 第32回バイオエンジニアリング講演会  2019.12 

    　More details

    Event date： 2019.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢商工会議所会館   Country：Japan  

  • 力学刺激に対する PKCαのトランスロケーションとキネシンの関係

    坂口 光輝, 古川 舜, 佐々木 沙織, 世良 俊博, 工藤 奨

    日本機械学会 第32回バイオエンジニアリング講演会  2019.12 

    　More details

    Event date： 2019.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：金沢商工会議所会館   Country：Japan  

  • 細胞培養ハイドロゲル表面リンクルの精密マルチスケール制御

    佐々木 沙織，木戸秋 悟

    日本機械学会 第 30 回バイオフロンティア講演会  2019.7 

    　More details

    Event date： 2019.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：霧島国際ホテル   Country：Japan  

  • 細胞外環境に応答した細胞内温度分布計測

    佐々木沙織，平井祐士，世良俊博，工藤奨

    第46回バイオレオロジー学会年会  2023.6 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：姫路   Country：Japan  

  • 隣接細胞剥離時の遊走関連タンパク質の数値解析

    佐々木沙織，江口慶太，牛島克恭，世良俊博，工藤奨

    第46回バイオレオロジー学会年会  2023.6 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：姫路   Country：Japan  

  • Development of a novel method for preparing physically cross-linked Poly(vinyl alcohol) gels International conference

    Saori Sasaki, Shoko Miyauchi, Ryo Takigawa

    MRM2023  2023.12 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Kyoto   Country：Japan  

  • 隣接細胞剥離時の遊走関連タンパク質の数値解析

    佐々木 沙織, 江口 慶太, 牛島 克恭, 世良 俊博, 工藤 奨

    日本バイオレオロジー学会誌(B&R)  2023.5  (NPO)日本バイオレオロジー学会

    　More details

    Language：Japanese  

  • 細胞微小変形時のモータータンパク質の挙動

    尾崎 郁美, 佐々木 沙織, 世良 俊博, 工藤 奨

    日本バイオレオロジー学会誌(B&R)  2023.5  (NPO)日本バイオレオロジー学会

    　More details

    Language：Japanese  

  • 細胞外環境に応答した細胞内温度分布計測

    佐々木 沙織, 平井 祐士, 世良 俊博, 工藤 奨

    日本バイオレオロジー学会誌(B&R)  2023.5  (NPO)日本バイオレオロジー学会

    　More details

    Language：Japanese  

  • 細胞変形時におけるYAP移動現象

    肖 博元, 大兼 健史, 佐々木 沙織, 世良 俊博, 工藤 奨

    日本バイオレオロジー学会誌(B&R)  2022.6  (NPO)日本バイオレオロジー学会

    　More details

    Language：Japanese  

  • 細胞のかたちづくりの原理に数理と実験で迫る　細胞が細胞を包むしくみ　血管内皮細胞と周皮細胞の場合

    杉原 圭, 佐々木 沙織, 木戸秋 悟, 植村 明嘉, 三浦 岳

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

    　More details

    Language：Japanese  

  • PKCα局在時におけるKeratin構造の影響

    森岡 真悠, 佐々木 沙織, 世良 俊博, 工藤 奨

    日本バイオレオロジー学会誌(B&R)  2023.5  (NPO)日本バイオレオロジー学会

    　More details

    Language：Japanese  

▼display all

Industrial property rights

Patent   Number of applications: 3   Number of registrations: 1
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Society of Polymer Science, Japan

  • The Japan Society of Mechanical Engineers

  • Japanese Society of Biorhelogy

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

    　 More details

  • THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

    　 More details

  • Japanese Society of Biorhelogy

    　 More details

▼display all

Committee Memberships

  • 日本機械学会 第34回バイオエンジニアリング講演会   実行委員  

    2022.6   

    　 More details

    Committee type：Academic society

    researchmap

  • 日本機械学会LAJ委員会   LAJ委員   Domestic

    2021.4 - Present   

  • 日本機械学会LAJ委員会   LAJ委員  

    2021.4 - Present   

    　 More details

    Committee type：Academic society

    researchmap

Academic Activities

  • Cluster Organizer International contribution

    MRM2023  （ Japan ） 2023.6 - 2023.12

    　More details

    Type：Competition, symposium, etc. 

  • 実行委員

    日本機械学会 第34回バイオエンジニアリング講演会  （ Japan ） 2022.6

    　More details

    Type：Competition, symposium, etc. 

Research Projects

  • 基材弾性率・表面凹凸構造に対する細胞の指向性遊走と応答解析

    Grant number：22K18172  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    佐々木 沙織

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    細胞遊走は、恒常性の維持、様々な生理機能の発現，組織・器官の発生において基礎をなす機能である。細胞は基材に応じて細胞挙動を変化させることが知られており、例えば硬さの違いを感知し、より硬い領域へ遊走する。申請者は近年、表面に微小な凹凸構造が存在するハイドロゲルを開発し、細胞が表面の微細凹凸構造の周期や大きさによって郵送挙動が異なる現象を見出した。本研究課題は、表面凹凸による細胞運動変化のメカニズムを解明することを目的とする。

    CiNii Research

  • 基材表面微小凹凸構造によって誘起される細胞の軟領域指向性運動メカニズムの解明

    2020.4 - 2022.3

    　 More details

    Authorship：Principal investigator 

  • 基材表面微小凹凸構造によって誘起される細胞の軟領域指向性運動メカニズムの解明

    Grant number：20K20183  2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    佐々木 沙織

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    細胞遊走は、恒常性の維持、様々な生理機能の発現，組織・器官の発生において基礎をなす機能である。従来研究において、細胞は基材の硬さの違いを感知し、より硬い領域へ遊走することが知られている。この運動はがん細胞などで観察されている。これに対して申請者は、表面に微小な凹凸構造が存在する時、細胞が従来とは逆に柔らかい基材に細胞が動くことを見出した。本研究課題は、表面凹凸による細胞運動変化のメカニズムを解明することを目的とする。

    CiNii Research

  • 細胞の指向性運動を利用した正常細胞とがん細胞の自発的な分離プラットフォームの確立

    2020

    公益財団法人吉田学術教育振興会 令和二年度学術奨励金

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

Educational Activities

  • 学部生・大学院生の研究指導、学部講義（学生実験）担当

Class subject

  • 機械工学実験第二（Bクラス）

    2024.10 - 2025.3   Second semester

  • 機械工学実験第二（Aクラス）

    2024.10 - 2025.3   Second semester

  • 機械工学実験第二（Aクラス）

    2023.10 - 2024.3   Second semester

  • 機械工学実験第二（Bクラス）

    2023.10 - 2024.3   Second semester

  • 機械工学実験第二（Aクラス）

    2022.10 - 2023.3   Second semester

  • 機械工学実験第二（Bクラス）

    2022.10 - 2023.3   Second semester

  • 機械工学実験第二（Aクラス）

    2021.10 - 2022.3   Second semester

  • 機械工学実験第二（Bクラス）

    2021.10 - 2022.3   Second semester

  • 機械工学実験第二（Aクラス）

    2020.10 - 2021.3   Second semester

  • 機械工学実験第二（Bクラス）

    2020.10 - 2021.3   Second semester

  • 機械工学実験第二（Aクラス）

    2019.10 - 2020.3   Second semester

  • 機械工学実験第二（Bクラス）

    2019.10 - 2020.3   Second semester

▼display all

FD Participation

  • 2020.12   Role：Participation   Title：Moodle&MS Teams連携によるオンライン講義実施報告(Youtube Prezi Powerpoint Wolframcloud そして TeX)

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.12   Role：Participation   Title：UQ-KU Education Forum 2020 (Day 1) −Teaching effectively in the time of COVID-19−

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.11   Role：Participation   Title：【機械系FD】学修目標を評価する意義と方法

    Organizer：University-wide

  • 2019.4   Role：Participation   Title：平成３１年度 第１回全学ＦＤ（新任教員の研修）

    Organizer：University-wide

Participation in international educational events, etc.

  • 2019.9

    九州大学国際教育支援センター

    教育の質向上支援プログラム(NEEP)「STEM科目の英語による教授法」

    　 More details

    Venue：オーストラリア・ブリスベン