記述言語：その他   掲載種別：研究論文（学術雑誌）  

Purpose: The thalamus, the region that forms the attentional network and transmits external sensory signals to the entire brain, is important for sleepiness. Herein, we examined the relationship between activity in the thalamus-seed brain network and subjective sleepiness.
Materials and Methods: Fifteen healthy male participants underwent an experiment comprising a baseline evaluation and two successive interventions, a 9-day sleep extension followed by 1-night total sleep deprivation. Pre- and post-intervention tests included the Karolinska sleepiness scale and neuroimaging for arterial spin labeling and functional connectivity. We examined the association between subjective sleepiness and the functional magnetic resonance imaging indices.
Results: The functional connectivity between the left or right thalamus and various brain regions displayed a significant negative association with subjective sleepiness, and the functional connectivity between the left and right thalamus displayed a significant positive association with subjective sleepiness. The graph theory analysis indicated that the number of positive functional connectivity related to the thalamus showed a strong negative association with subjective sleepiness, and conversely, the number of negative functional connectivity showed a positive association with subjective sleepiness. Arterial spin labeling analysis indicated that the blood flow in both the left and right thalami was significantly negatively associated with subjective sleepiness. Functional connectivity between the anterior cingulate cortex and salience network areas of the left insular cortex, and that between the anterior and posterior cingulate cortices showed a strong positive and negative association with subjective sleepiness, respectively.
Conclusion: Subjective sleepiness and the thalamic-cortical network dynamics are strongly related, indicating the application of graph theory to study sleepiness and consciousness. These results also demonstrate that resting functional connectivity largely reflects the “state” of the subject, suggesting that the control of sleep and conscious states is essential when using functional magnetic resonance imaging indices as biomarkers.

DOI： 10.2147/nss.s297309

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/09291016.2020.1782691

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/07420528.2020.1752704

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open-the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300-500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named "eye-metrical estimation version of the PVT: PVT-E," can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate.

DOI： 10.1093/sleep/zsz219

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Cortisol is known to affect visuospatial memory through its major binding site in the brain, the hippocampus. The synchronization of neural activity between the hippocampus, prefrontal cortex (PFC), and visual cortex is presumed to be essential for the formation of visuospatial memory because of their visuospatial learning-dependent neuroplasticity. However, it remains unclear how hippocampal connectivity with the PFC and visual cortex is involved in the relationship between cortisol and visuospatial memory in humans. We thus investigated whether functional connectivity (FC) of the hippocampus, specifically its rostral and caudal subdivisions, mediates the relationship between visuospatial memory and endogenous cortisol. One-hundred sixty-six healthy young adults underwent standard neuropsychological tests to assess visuospatial construction (a complex figure copying test) and retrieval (the corresponding recall test) and collected their saliva at 6-time points across 2 consecutive days for measurement of daily cortisol concentrations (dCOR). Ninety of them received resting-state fMRI scans. Greater dCOR was significantly associated with better figure copying performance, but contrastingly with poorer figure recall. In proportion to dCOR, the rostral hippocampus (rHC) showed significantly increased FC with the PFC (including its dorsolateral and medial parts) and the inferior lateral occipital cortex (iLOC), while the caudal hippocampus had increased FC with the anterior middle temporal cortex. Of the cortisol-related hippocampal connectivity, the rHC-iLOC FC was specifically correlated with figure recall and showed complete mediation for the negative relationship of dCOR with figure recall. These results suggest that cortisol might have enhancing effects on visuospatial encoding as well as impairing effects on visuospatial retrieval, possibly due to its occupancy patterns of corticosteroid receptors. Cortisol's adverse effects on visuospatial retrieval might be explained through cortisol-related rostral hippocampal connectivity with the iLOC, which is a part of the extrastriate cortex implicated in visuospatial perception. Thorough dissection of hippocampal-prefrontal-extrastriate connectivity might facilitate the understanding of neural mechanisms underlying cortisol's contrasting effects on encoding (or consolidation) and retrieval of visuospatial information.

DOI： 10.1016/j.psyneuen.2019.04.013

記述言語：日本語   掲載種別：研究論文（国際会議プロシーディングス）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children's facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving. Methods: Participants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured. Results: The results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors. Conclusions: Our findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions.

DOI： 10.1186/s40101-019-0196-z

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jad.2018.06.018

記述言語：日本語  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.

DOI： 10.1093/sleep/zsx137

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Study objectives: Sleep debt (SD) has been suggested to evoke emotional instability by diminishing the suppression of the amygdala by the medial prefrontal cortex (MPFC). Here, we investigated how short-term SD affects resting-state functional connectivity between the amygdala and MPFC, self-reported mood, and sleep parameters.
Methods: Eighteen healthy adult men aged 29 +/- 8.24 years participated in a 2-day sleep control session (SC; time in bed [ TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each session, resting-state functional magnetic resonance imaging was performed, followed immediately by measuring self-reported mood on the State-Trait Anxiety Inventory-State subscale (STAI-S).
Results: STAI-S score was significantly increased, and functional connectivity between the amygdala and MPFC was significantly decreased in SD compared with SC. Significant correlations were observed between reduced rapid eye movement (REM) sleep and reduced left amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced FCL_amg-MPFC and increased STAI-S score in SD compared with SC.
Conclusions: These findings suggest that reduced MPFC functional connectivity of amygdala activity is involved in mood deterioration under SD, and that REM sleep reduction is involved in functional changes in the corresponding brain regions. Having adequate REM sleep may be important for mental health maintenance.

DOI： 10.1093/sleep/zsx133

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22.80 +/- 0.47 (mean +/- s.d.) h in control-derived fibroblasts. The in vitro periods in DSWPD-derived fibroblasts and N24SWD-derived fibroblasts were 22.67 +/- 0.67 h and 23.18 +/- 0.70 h, respectively. The N24SWD group showed a significantly longer in vitro period than did the control or DSWPD group. Furthermore, in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders (mean +/- s.d.: 23.59 +/- 0.89 h) compared with the responders (mean +/- s.d.: 22.97 +/- 0.47 h) in the N24SWD group. Our results indicate that prolonged circadian periods contribute to the onset and poor treatment outcome of N24SWD. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSDs.

DOI： 10.1038/tp.2017.75

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0128005

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40101-015-0053-7

記述言語：英語  

DOI： 10.1016/j.ijpsycho.2014.08.892

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/1880-6805-33-31

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/1471-2202-15-97

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

In todays modern society, an increasing number of people have developed sleep-related problems, represented by sleep loss and chronic insomnia. These are due to drastic changes in living conditions such as prolonged work time, increased shift working, and various sociopsychological stresses. Sleep problems have been reported to strongly associate with emotional dysfunction in humans. Sleep loss cause not only daytime sleepiness and psychomotor impairment, but also emotional instability, anxiety and confusion, and chronic insomnia increases vulnerability to mood and anxiety disorders. Recent studies have revealed some of the neural basis of emotional regulation by sleep. For instance, continuous and accumulating sleep debt experienced in daily living could interfere with the functional regulation of the amygdala by ventral anterior cingulate cortex. And consequently this can induce an overreaction of the amygdala to negative emotional stimuli. Sleep-related mood disturbances may, in part, be attributable to the neural basis of emotional instability during sleep debt. In this text, recent findings on the functional linkage between sleep and emotional regulation have been reviewed.

記述言語：その他  

ASSOCIATION BETWEEN EMOTIONAL AWARENESS AND NEURAL CORRELATES OF INTEROCEPTION

記述言語：その他  

THE ASSOCIATION BETWEEN NEURAL RESPONSE AND HEART RATE VARIABILITY DURING ATTENDING TO BODILY SENSATIONS

記述言語：その他  

SLEEPINESS BY SLEEP DEBT ENHANCED AMYGDALA ACTIVATION FOR SUBLIMINAL SIGNALS OF FEAR

記述言語：その他  

WHY SLEEP DEPRIVATION RISK US OBESITY? AN FMRI STUDY

記述言語：その他  

THE NEURAL SUBSTRATES OF THE EMOTIONAL AUTOBIOGRAPHICAL MEMORY RETRIEVAL AND ITS RELATION TO ADAPTIVE COPING

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives: Sleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness and psychomotor impairment. However, the neural basis of emotional instability due to sleep debt has yet to be elucidated. This study investigated changes in emotional responses that are elicited by the simulation of short-term sleep loss and the brain regions responsible for these changes.
Subjects and Methods: Fourteen healthy adult men aged 24.1 +/- 3.3 years (range, 20-32 years) participated in a within-subject crossover study consisting of 5-day sessions of both sleep debt (4 h for time in bed) and sleep control (8 h for time in bed). On the last day of each session, participants underwent polysomnography and completed the State-Trait Anxiety Inventory and Profile of Mood States questionnaires. In addition, functional magnetic resonance imaging was conducted while performing an emotional face viewing task.
Results: Restricted sleep over the 5-day period increased the activity of the left amygdala in response to the facial expression of fear, whereas a happy facial expression did not change the activity. Restricted sleep also resulted in a significant decrease in the functional connectivity between the amygdala and the ventral anterior cingulate cortex (vACC) in proportion to the degree of sleep debt (as indicated by the percentage of slow wave sleep and delta wave power). This decrease was significantly correlated with activation of the left amygdala and deterioration of subjective mood state.
Conclusion: The results of this study suggest that continuous and accumulating sleep debt that can be experienced in everyday life can downregulate the functional suppression of the amygdala by the vACC and consequently enhance the response of the amygdala to negative emotional stimuli. Such functional alteration in emotional control may, in part, be attributed to the neural basis of emotional instability during sleep debt.

DOI： 10.1371/journal.pone.0056578

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0056578

開催年月日： 2023年6月

記述言語：英語  

国名：日本国  

開催年月日： 2023年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2021年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2021年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2021年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2021年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2021年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年8月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年6月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

国名：日本国  

開催年月日： 2020年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

国名：日本国  

開催年月日： 2020年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2020年6月

記述言語：英語  

国名：日本国  

開催年月日： 2020年2月

記述言語：英語  

開催地：Modena   国名：イタリア共和国  

Managing negative emotions and promptly relieving anxiety are two main focuses in the prevention of mental illness. This paper indicates a biofeedback-training experience that helps an experiencer to manage his/her emotions. The authors have defined the following major problems to approach this bio-feedback design procedure. The first one is how to grasp human emotions using existing technologies in exhibition circumstances. The second one is what kind of manifestation should be used to create emotional resonance. For the first problem, Heart Rate Variability (HRV) is adopted to obtain anxiety and stress levels. For the second problem, the authors took a nature-inspired design approach. The results are visualized on a wall composed of 64 bionic scales. A device system guides the experiencer into a meditative state, and contributes to spurring thoughts on emotional management, and thus achieving the purpose of preventing mental illness.

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2019年6月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

国名：日本国  

開催年月日： 2019年3月 - 2019年6月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年12月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年10月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年10月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年7月

記述言語：英語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年6月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2018年5月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2018年5月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：その他  

国名：マレーシア  

記述言語：その他  

国名：マレーシア  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

国名：日本国  

記述言語：日本語  

潜在的睡眠不足からの回復は前頭前野による扁桃体賦活抑制機能の改善を介して気分を改善する ASL-fMRI研究

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語  

記述言語：日本語  

・近年になり、日常生活で蓄積した睡眠負債の悪影響が注目され始めている。睡眠負債は眠気や精神運動機能の低下を引き起こし、情動調節機能の障害とも強い関連性をもつことが多く報告されている。・最近の研究において、睡眠負債がいかにして認知機能や情動に影響するか、その神経科学的メカニズムが部分的にではあるが明らかになってきている。例えば、認知機能の低下には睡眠促進物質の蓄積や全般的な注意機能を司る脳領域の機能低下がその背景にあることや、睡眠不足時には前頭領域による扁桃体の抑制機能の低下が気分の不安定性を引き起こすことが明らかにされている。・本稿では、筆者らの研究成果を交えながら、睡眠負債による認知機能・情動調節機能低下の脳内メカニズムに迫る近年の研究について概説する。(著者抄録)

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

視床を中心とする脳内ネットワークと主観的眠気の関連 安静時fMRIによる検討

記述言語：日本語  

慢性不眠症患者の情動機能 fMRI研究

記述言語：日本語  

概日リズムへ影響する日常生活光の特性

記述言語：日本語  

記述言語：日本語  

新型分光放射照度センサーを使用した身体装着部位と光曝露との関連

記述言語：日本語  

睡眠負債時における顔表情認知と情動伝染

記述言語：日本語  

睡眠負債が道徳的行動に及ぼす影響とその神経基盤

記述言語：日本語  

眼球運動と眼瞼運動を用いた眠気による注意低下の状態推定法

記述言語：日本語  

概日リズム睡眠障害の治療反応性と末梢時計リズム周期

記述言語：日本語  

日常生活における睡眠負債が肥満に及ぼす神経学的検証

記述言語：日本語  

睡眠負債時における安静時気分の低下とその神経基盤 fMRI研究

記述言語：日本語  

睡眠負債時における安静時気分の低下とその神経基盤 fMRI研究

記述言語：日本語  

睡眠相後退型、フリーラン型の末梢時計リズム周期

記述言語：日本語  

睡眠相後退型、フリーラン型の末梢時計リズム周期

記述言語：日本語  

日常生活における睡眠負債が肥満に及ぼす神経学的検証

記述言語：日本語  

近年、睡眠や概日リズム機構の障害が気分調節に影響を与えることが示されており、鬱病、不安障害の発症や日中の抑鬱のリスク要因としても注目されている。その背景には、生活要因や生体リズム異常に起因する「睡眠の不調の影響」と、「生体リズム異常そのものの影響」の二つの要因が重なっていると考えられる。睡眠不足や不眠が気分調節機能や精神疾患の発症に及ぼす影響とそのメカニズム、さらに概日リズム機構と気分調節の連関メカニズムに関して、現在までに得られている知見を概説した。

記述言語：日本語  

正または負の事象への共感に相手との親密性が与える影響

記述言語：日本語  

精神生理研究部 睡眠延長による必要睡眠量と潜在的睡眠負債の推定

記述言語：日本語  

精神生理研究部 原発性不眠症患者における情動刺激観察時の脳活動

記述言語：日本語  

精神生理研究部 睡眠延長による必要睡眠量と潜在的睡眠負債の推定

記述言語：日本語  

原発性不眠症患者は報酬処理に関連する脳部位の活動低下を示す fMRI研究

記述言語：日本語  

肥満に関連する睡眠および食習慣の検討

記述言語：日本語  

どのような睡眠習慣と食習慣が肥満リスクを高めるか

記述言語：日本語  

睡眠延長による潜在的睡眠負債からの回復が気分調節に与える影響

記述言語：日本語  

宇宙飛行士のヴィジランス評価における新規指標の必要性

記述言語：日本語  

睡眠習慣および食習慣と肥満との関連に関する検討

記述言語：日本語  

睡眠延長による必要睡眠量と潜在的睡眠負債の推定

記述言語：日本語  

概日リズム睡眠障害の発症機序 末梢時計機能の評価

記述言語：日本語  

慢性不眠症患者の脳構造 Voxel-based Morphometryを用いた検討

記述言語：日本語  

睡眠延長による潜在的睡眠負債からの回復が気分調節に与える影響

記述言語：日本語  

現代社会では,増え続ける長時間労働やシフトワーク,さまざまな社会心理的ストレスなどの生活状況のめまぐるしい変化によって睡眠不足や不眠などの睡眠問題が増加しており,多くの現代人がこの問題に悩まされている。睡眠問題は情動機能の障害と強い関連性を持つことを示唆する数多くの報告がある。睡眠不足は眠気や精神運動機能の低下だけではなく,不安や混乱などの情動的不安定性を増加させる。また,慢性不眠症は気分障害,不安障害の発症脆弱性を高める。最近の研究によって,不適切な睡眠習慣による情動調節の障害メカニズムが,部分的にではあるが解明されつつある。例えば,日常的に体験するレベルの睡眠不足の蓄積により腹側前帯状皮質による扁桃体活動の調節異常が生じ,ネガティブな情動刺激に対する扁桃体の過剰反応が生じることが明らかになった。このような睡眠障害に起因する情動反応の亢進は,睡眠不足時にみられる情動的不安定性とその神経基盤を一部共有している可能性がある。本稿では,睡眠と情動調節の機能的連関に関する近年の研究について概説する。(著者抄録)

記述言語：日本語  

睡眠習慣と摂食行動および肥満との関連

記述言語：日本語  

若年者の睡眠習慣と肥満リスクに関する基礎的研究

記述言語：日本語  

リアルタイムfMRIを用いたストレス関連疾患の治療法の開発

記述言語：日本語  

新しい活動量計における睡眠/覚醒判定アルゴリズムの検討

記述言語：日本語  

無意識的な情動伝達経路の役割 強い眠気は意識下で呈示された恐怖表情刺激に対する情動関連脳領域の活動を増強する

記述言語：日本語  

安静時脳活動の測定による原発性不眠症患者における神経科学的病態の検討

記述言語：日本語  

無意識的な情動伝達経路の役割:強い眠気は意識下で呈示された恐怖表情刺激に対する情動関連脳領域の活動を増強する

記述言語：日本語  

概日リズム睡眠障害患者の生物時計機能障害

記述言語：日本語  

新しい活動量計を用いた睡眠/覚醒判定アルゴリズムの作成

記述言語：英語  

記述言語：日本語  

睡眠負債は扁桃体 前頭前野間の機能的結合の減弱を介して、ネガティブな情動反応を惹起する

記述言語：日本語  

睡眠負債は扁桃体‐前頭前野間の機能的結合の減弱を介して,ネガティブな情動反応を惹起する

記述言語：日本語  

睡眠のマルチモダル画像研究 脳機能画像解析からみた睡眠負債時の情動・認知機能障害メカニズム

記述言語：日本語  

短時間睡眠による睡眠負債が情動に関する脳機能に及ぼす影響

記述言語：日本語  

部分断眠による睡眠負債が情動反応に与える影響 機能的MRIを用いた検討

記述言語：日本語  

視覚が健常な概日リズム睡眠障害(自由継続型)患者は長い概日リズム周期を持つ

記述言語：日本語  

部分断眠による睡眠負債が情動反応に与える影響:機能的MRIを用いた検討

記述言語：日本語  

共感性の個人差と脳活動の関連性 事象関連電位を用いた検討

種別：学会・研究会等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：査読等 

外国語雑誌　査読論文数：2

日本語雑誌　査読論文数：2