Updated on 2024/11/01

Information

 

写真a

 
SUZUKI TAKAHIRO
 
Organization
Faculty of Agriculture Department of Bioresource Sciences Associate Professor
School of Agriculture Department of Bioresource and Bioenvironment(Concurrent)
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioresource Sciences(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Profile
私は、骨格筋の幹細胞(衛星細胞)を対象とした筋細胞生物学に関する基礎的な研究活動を中心に取り組み、新たな知見から得られた情報を応用することで、アニマルサイエンス(特に食肉科学)分野や健康・スポーツ科学分野への貢献を目指しています。
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Research Areas

  • Life Science / Cell biology

  • Life Science / Animal production science

Degree

  • Ph. D.

Research History

  • Research Faculty of Agriculture, Kyushu University Department of Animal and Marine Bioresource Sciences Associate Professor 

    2020.10 - Present

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  • 2014年4月-2015年9月 川崎医科大学 分子生物学教室1 (日本学術振興会特別研究員 PD) 2015年10月-2020年9月 北海道大学 大学院農学研究院 (助教)   

Research Interests・Research Keywords

  • Research theme: skeletal muscle

    Keyword: skeletal muscle

    Research period: 2024

  • Research theme: Satellite Cell Heterogeneity

    Keyword: Satellite Cell Heterogeneity

    Research period: 2024

  • Research theme: muscle fiber type

    Keyword: muscle fiber type

    Research period: 2024

  • Research theme: satellite cell

    Keyword: satellite cell

    Research period: 2024

  • Research theme: semaphorins and netrins

    Keyword: semaphorins and netrins

    Research period: 2024

  • Research theme: Satellite cells are resident myogenic stem cells positioned beneath the basal lamina of mature myofibers. These cells differentiate to form nascent myofibers (myotubes) or fuse to injured myofibers for skeletal muscle regeneration and hypertrophy. Numerous studies focusing on cell dynamics such as quiescence, activation, proliferation, and differentiation, have shown that satellite cells exhibit heterogeneities based on the expression patterns of key transcription factors and cellular membrane proteins and determine the cell fate/linage. My research topics have directly focused on characterization of satellite cells based on myofiber types.

    Keyword: Skeletal muscle, Myogenic stem cells (Satellite cells), Myofiber type, Multipotent-modulator, Functional heterogeneity

    Research period: 2020.10

Awards

  • 2017年度日本畜産学奨励賞

    2017.3   日本畜産学会   筋幹細胞分泌因子semaphorin 3Aによる筋線維型自律制御機構に関する研究

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    http://www.jsas-org.jp/hyousyou/2017/syourei17.html

  • 平成25年度 生物資源環境科学府賞

    2014.3   九州大学大学院 生物資源科学府   Generation of slow myofiber by semaphorin 3A secreted from resident myogenic stem cells during muscle regeneration.」 (骨格筋再生過程において筋幹細胞から分泌されるsemaphorin 3A は新生筋線維の遅筋化を誘導する)

Papers

  • Netrin-4 synthesized in satellite cell-derived myoblasts stimulates autonomous fusion Reviewed International journal

    Takahiro Maeno, Rio Arimatsu, Koichi Ojima, Yuki Yamaya, Hikaru Imakyure, Naruha Watanabe, Yusuke Komiya, Ken Kobayashi, Mako Nakamura, Takanori Nishimura, Ryuichi Tatsumi, Takahiro Suzuki

    Experimental Cell Research   430 ( 1 )   113698 - 113698   2023.9   ISSN:0014-4827 eISSN:1090-2422

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    Satellite cells are indispensable for skeletal muscle regeneration and hypertrophy by forming nascent myofibers (myotubes). They synthesize multi-potent modulator netrins (secreted subtypes: netrin-1, -3, and -4), originally found as classical neural axon guidance molecules. While netrin-1 and -3 have key roles in myogenic differentiation, the physiological significance of netrin-4 is still unclear. This study examined whether netrin-4 regulates myofiber type commitment and myotube formation. Initially, the expression profiles indicated that satellite cells isolated from the extensor digitorum longus muscle (EDL muscle: fast-twitch myofiber-abundant) expressed slightly more netrin-4 than the soleus muscle (slow-type abundant) cells. As netrin-4 knockdown inhibited both slow- and fast-type myotube formation, netrin-4 may not directly regulate myofiber type commitment. However, netrin-4 knockdown in satellite cell-derived myoblasts reduced the myotube fusion index, while exogenous netrin-4 promoted myotube formation, even though netrin-4 expression level was maximum during the initiation stage of myogenic differentiation. Furthermore, netrin-4 knockdown also inhibited MyoD (a master transcriptional factor of myogenesis) and Myomixer (a myoblast fusogenic molecule) expression. These data suggest that satellite cells synthesize netrin-4 during myogenic differentiation initiation to promote their own fusion, stimulating the MyoD–Myomixer signaling axis.

    DOI: 10.1016/j.yexcr.2023.113698

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  • Abundant Synthesis of Netrin-1 in Satellite Cell-Derived Myoblasts Isolated from EDL Rather Than Soleus Muscle Regulates Fast-Type Myotube Formation Reviewed International journal

    Takahiro Suzuki, Aika Mori, Takahiro Maeno, Rio Arimatsu, Emi Ichimura, Yuriko Nishi, Kouga Hisaeda, Yuki Yamaya, Ken Kobayashi, Mako Nakamura, Ryuichi Tatsumi, Koichi Ojima, Takanori Nishimura

    International Journal of Molecular Sciences   22 ( 9 )   4499 - 4499   2021.4

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    Resident myogenic stem cells (satellite cells) are attracting attention for their novel roles in myofiber type regulation. In the myogenic differentiation phase, satellite cells from soleus muscle (slow fiber-abundant) synthesize and secrete higher levels of semaphorin 3A (Sema3A, a multifunctional modulator) than those derived from extensor digitorum longus (EDL; fast fiber-abundant), suggesting the role of Sema3A in forming slow-twitch myofibers. However, the regulatory mechanisms underlying fast-twitch myotube commitment remain unclear. Herein, we focused on netrin family members (netrin-1, -3, and -4) that compete with Sema3A in neurogenesis and osteogenesis. We examined whether netrins affect fast-twitch myotube generation by evaluating their expression in primary satellite cell cultures. Initially, netrins are upregulated during myogenic differentiation. Next, we compared the expression levels of netrins and their cell membrane receptors between soleus- and EDL-derived satellite cells; only netrin-1 showed higher expression in EDL-derived satellite cells than in soleus-derived satellite cells. We also performed netrin-1 knockdown experiments and additional experiments with recombinant netrin-1 in differentiated satellite cell-derived myoblasts. Netrin-1 knockdown in myoblasts substantially reduced fast-type myosin heavy chain (MyHC) expression; exogenous netrin-1 upregulated fast-type MyHC in satellite cells. Thus, netrin-1 synthesized in EDL-derived satellite cells may promote myofiber type commitment of fast muscles.

    DOI: 10.3390/ijms22094499

  • Adipocytes suppress differentiation of muscle cells in a co-culture system Reviewed International journal

    Kangmin Seo, Takahiro Suzuki, Ken Kobayashi, Takanori Nishimura

    Animal Science Journal   90 ( 3 )   423 - 434   2019.3

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    DOI: 10.1111/asj.13145

  • Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells. Reviewed International journal

    Tatsumi R, Suzuki T, Do MQ, Ohya Y, Anderson JE, Shibata A, Kawaguchi M, Ohya S, Ohtsubo H, Mizunoya W, Sawano S, Komiya Y, Ichitsubo R, Ojima K, Nishimatsu SI, Nohno T, Ohsawa Y, Sunada Y, Nakamura M, Furuse M, Ikeuchi Y, Nishimura T, Yagi T, Allen RE

    Stem cells   35 ( 7 )   1815 - 1834   2017.7

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    Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells

    DOI: 10.1002/stem.2639

  • Comparative analysis of semaphorin 3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression Reviewed International journal

    Takahiro Suzuki, Mai-Khoi Q. Do, Yusuke Sato, Koichi Ojima, Minako Hara, Wataru Mizunoya, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi

    The International Journal of Biochemistry & Cell Biology   45 ( 2 )   476 - 482   2013.2

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    DOI: 10.1016/j.biocel.2012.10.003

  • In vitro immuno-prevention of nitration/dysfunction of myogenic stem cell activator HGF, towards developing a strategy for age-related muscle atrophy. International journal

    Sakiho Tanaka, Alaa Elgaabari, Miyumi Seki, So Kuwakado, Kahona Zushi, Junri Miyamoto, Shoko Sawano, Wataru Mizunoya, Kenshiro Ehara, Naruha Watanabe, Yohei Ogawa, Hikaru Imakyure, Reina Fujimaru, Rika Osaki, Kazuki Shitamitsu, Kaoru Mizoguchi, Tomoki Ushijima, Takahiro Maeno, Takashi Nakashima, Takahiro Suzuki, Mako Nakamura, Judy E Anderson, Ryuichi Tatsumi

    Aging cell   23 ( 10 )   e14337   2024.10   ISSN:1474-9718 eISSN:1474-9726

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    In response to peroxynitrite (ONOO-) generation, myogenic stem satellite cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198 and Y250) predominantly on fast IIa and IIx myofibers to lose its binding to the signaling receptor c-met, thereby disturbing muscle homeostasis during aging. Here we show that rat anti-HGF monoclonal antibody (mAb) 1H41C10, which was raised in-house against a synthetic peptide FTSNPEVRnitroY198EV, a site well-conserved in mammals, functions to confer resistance to nitration dysfunction on HGF. 1H41C10 was characterized by recognizing both nitrated and non-nitrated HGF with different affinities as revealed by Western blotting, indicating that the paratope of 1H41C10 may bind to the immediate vicinity of Y198. Subsequent experiments showed that 1H41C10-bound HGF resists peroxynitrite-induced nitration of Y198. A companion mAb-1H42F4 presented similar immuno-reactivity, but did not protect Y198 nitration, and thus served as the control. Importantly, 1H41C10-HGF also withstood Y250 nitration to retain c-met binding and satellite cell activation functions in culture. The Fab region of 1H41C10 exerts resistivity to Y250 nitration possibly due to its localization in the immediate vicinity to Y250, as supported by an additional set of experiments showing that the 1H41C10-Fab confers Y250-nitration resistance which the Fc segment does not. Findings highlight the in vitro preventive impact of 1H41C10 on HGF nitration-dysfunction that strongly impairs myogenic stem cell dynamics, potentially pioneering cogent strategies for counteracting or treating age-related muscle atrophy with fibrosis (including sarcopenia and frailty) and the therapeutic application of investigational HGF drugs.

    DOI: 10.1111/acel.14337

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  • Murf1 alters myosin replacement rates in cultured myotubes in a myosin isoform-dependent manner. International journal

    Emi Uenaka, Koichi Ojima, Takahiro Suzuki, Ken Kobayashi, Susumu Muroya, Takanori Nishimura

    In vitro cellular & developmental biology. Animal   60 ( 7 )   748 - 759   2024.8   ISSN:1071-2690 eISSN:1543-706X

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:In Vitro Cellular and Developmental Biology - Animal  

    Skeletal muscle tissue increases or decreases its volume by synthesizing or degrading myofibrillar proteins. The ubiquitin-proteasome system plays a pivotal role during muscle atrophy, where muscle ring finger proteins (Murf) function as E3 ubiquitin ligases responsible for identifying and targeting substrates for degradation. Our previous study demonstrated that overexpression of Ozz, an E3 specific to embryonic myosin heavy chain (Myh3), precisely reduced the Myh3 replacement rate in the thick filaments of myotubes (E. Ichimura et al., Physiol Rep. 9:e15003, 2021). These findings strongly suggest that E3 plays a critical role in regulating myosin replacement. Here, we hypothesized that the Murf isoforms, which recognize Myhs as substrates, reduced the myosin replacement rates through the enhanced Myh degradation by Murfs. First, fluorescence recovery after a photobleaching experiment was conducted to assess whether Murf isoforms affected the GFP-Myh3 replacement. In contrast to Murf2 or Murf3 overexpression, Murf1 overexpression selectively facilitated the GFP-Myh3 myosin replacement. Next, to examine the effects of Murf1 overexpression on the replacement of myosin isoforms, Cherry-Murf1 was coexpressed with GFP-Myh1, GFP-Myh4, or GFP-Myh7 in myotubes. Intriguingly, Murf1 overexpression enhanced the myosin replacement of GFP-Myh4 but did not affect those of GFP-Myh1 or GFP-Myh7. Surprisingly, overexpression of Murf1 did not enhance the ubiquitination of proteins. These results indicate that Murf1 selectively regulated myosin replacement in a Myh isoform-dependent fashion, independent of enhanced ubiquitination. This suggests that Murf1 may have a role beyond functioning as a ubiquitin ligase E3 in thick filament myosin replacement.

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  • Eicosapentaenoic acid increases proportion of type 1 muscle fibers through PPARδ and AMPK pathways in rats International journal

    Yusuke Komiya, Yuka Sakazaki, Tsuyoshi Goto, Fuminori Kawabata, Takahiro Suzuki, Yusuke Sato, Shoko Sawano, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Keizo Arihara, Wataru Mizunoya

    iScience   27 ( 6 )   109816 - 109816   2024.6   ISSN:2589-0042 eISSN:2589-0042

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    Eicosapentaenoic acid increases proportion of type 1 muscle fibers through PPARδ and AMPK pathways in rats

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  • 第26回若手企画シンポジウム「どうする?どうなる!?日本の畜産業界 〜現状と現場を知る〜」の開催報告

    大塚 剛司, 長澤 麻央, 鈴木 貴弘, 吉田 悠太, 渡邊 源哉

    Nihon Chikusan Gakkaiho   95 ( 2 )   103 - 105   2024.5   ISSN:1346907X eISSN:18808255

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    <p>日本畜産学会若手企画委員会は,分野や所属の垣根を越えた若手研究者のネットワーク構築および今後のキャリアパスの参考となる様々な企画を実施している.そして,若手研究者の奮起と成長を促すことで,今後の畜産学および畜産業の発展に貢献することを目的とする.本稿では,2023年9月19日の第131回日本畜産学会大会において,4年ぶりに対面開催された「第26回若手企画シンポジウム どうする?どうなる!?日本の畜産業界 〜現状と現場を知る〜」について,簡単に紹介する.</p>

    DOI: 10.2508/chikusan.95.103

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  • C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation International journal

    Chi Sun Yun, Yuyu Saito, Al-Nur Md, Iftekhar Rahman, Takahiro Suzuki, Hideyuki Takahashi, Keiichiro Kizaki, M. A. M, Yahia Khandoker, Nobuhiko Yamauchi

    Cell and Tissue Research   396 ( 2 )   231 - 243   2024.3   ISSN:0302-766X eISSN:1432-0878

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    C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation

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    Other Link: https://link.springer.com/article/10.1007/s00441-024-03869-8/fulltext.html

  • Age-related nitration/dysfunction of myogenic stem cell activator HGF. International journal

    Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Takashi Nakashima, Shoko Okuda, Yoshitaka Manabe, Shoko Sawano, Wataru Mizunoya, Ryuki Kaneko, Sakiho Tanaka, Takahiro Maeno, Yuji Matsuyoshi, Miyumi Seki, So Kuwakado, Kahona Zushi, Nasibeh Daneshvar, Mako Nakamura, Takahiro Suzuki, Kenji Sunagawa, Judy E Anderson, Ronald E Allen, Ryuichi Tatsumi

    Aging cell   23 ( 2 )   e14041   2024.2   ISSN:1474-9718 eISSN:1474-9726

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    Mechanical perturbation triggers activation of resident myogenic stem cells to enter the cell cycle through a cascade of events including hepatocyte growth factor (HGF) release from its extracellular tethering and the subsequent presentation to signaling-receptor c-met. Here, we show that with aging, extracellular HGF undergoes tyrosine-residue (Y) nitration and loses c-met binding, thereby disturbing muscle homeostasis. Biochemical studies demonstrated that nitration/dysfunction is specific to HGF among other major growth factors and is characterized by its locations at Y198 and Y250 in c-met-binding domains. Direct-immunofluorescence microscopy of lower hind limb muscles from three age groups of rat, provided direct in vivo evidence for age-related increases in nitration of ECM-bound HGF, preferentially stained for anti-nitrated Y198 and Y250-HGF mAbs (raised in-house) in fast IIa and IIx myofibers. Overall, findings highlight inhibitory impacts of HGF nitration on myogenic stem cell dynamics, pioneering a cogent discussion for better understanding age-related muscle atrophy and impaired regeneration with fibrosis (including sarcopenia and frailty).

    DOI: 10.1111/acel.14041

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  • Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice

    Yusuke Komiya, Shugo Iseki, Masaru Ochiai, Yume Takahashi, Issei Yokoyama, Takahiro Suzuki, Ryuichi Tatsumi, Shoko Sawano, Wataru Mizunoya, Keizo Arihara

    Scientific Reports   14 ( 1 )   755   2024.1   ISSN:2045-2322

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    Abstract

    Skeletal muscle is one of the largest metabolic tissues in mammals and is composed of four different types of muscle fibers (types 1, 2A, 2X, and 2B); however, type 2B is absent in humans. Given that slow-twitch fibers are superior to fast-twitch fibers in terms of oxidative metabolism and are rich in mitochondria, shift of muscle fiber types in direction towards slower fiber types improves metabolic disorders and endurance capacity. We previously had reported that oleic acid supplementation increases type 1 fiber formation in C2C12 myotubes; however, its function still remains unclear. This study aimed to determine the effect of oleic acid on the muscle fiber types and endurance capacity. An in vivo mouse model was used, and mice were fed a 10% oleic acid diet for 4 weeks. Two different skeletal muscles, slow soleus muscle with the predominance of slow-twitch fibers and fast extensor digitorum longus (EDL) muscle with the predominance of fast-twitch fibers, were used. We found that dietary oleic acid intake improved running endurance and altered fiber type composition of muscles, the proportion of type 1 and 2X fibers increased in the soleus muscle and type 2X increased in the EDL muscle. The fiber type shift in the EDL muscle was accompanied by an increased muscle TAG content. In addition, blood triacylglycerol (TAG) and non-esterified fatty acid levels decreased during exercise. These changes suggested that lipid utilization as an energy substrate was enhanced by oleic acid. Increased proliferator-activated receptor γ coactivator-1β protein levels were observed in the EDL muscle, which potentially enhanced the fiber type transitions towards type 2X and muscle TAG content. In conclusion, dietary oleic acid intake improved running endurance with the changes of muscle fiber type shares in mice. This study elucidated a novel functionality of oleic acid in skeletal muscle fiber types. Further studies are required to elucidate the underlying mechanisms. Our findings have the potential to contribute to the field of health and sports science through nutritional approaches, such as the development of supplements aimed at improving muscle function.

    DOI: 10.1038/s41598-023-50464-y

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  • Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia. International journal

    Yutaka Ohsawa, Hideaki Ohtsubo, Asami Munekane, Kohei Ohkubo, Tatsufumi Murakami, Masahiro Fujino, Shin-Ichiro Nishimatsu, Hiroki Hagiwara, Hirotake Nishimura, Ryuki Kaneko, Takahiro Suzuki, Ryuichi Tatsumi, Wataru Mizunoya, Atsushi Hinohara, Masao Fukunaga, Yoshihide Sunada

    The American journal of pathology   193 ( 5 )   591 - 607   2023.5   ISSN:0002-9440 eISSN:1525-2191

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    α-Klotho is a longevity-related protein. Its deficiency shortens lifespan with prominent senescent phenotypes, including muscle atrophy and weakness in mice. α-Klotho has two forms: membrane α-Klotho and circulating α-Klotho (c-α-Klotho). Loss of membrane α-Klotho impairs a phosphaturic effect, thereby accelerating phosphate-induced aging. However, the mechanisms of senescence on c-α-Klotho loss remain largely unknown. Herein, with the aging of wild-type mice, c-α-Klotho declined, whereas Smad2, an intracellular transforming growth factor (TGF)-β effector, became activated in skeletal muscle. Moreover, c-α-Klotho suppressed muscle-wasting TGF-β molecules, including myostatin, growth and differentiation factor 11, activin, and TGF-β1, through binding to ligands as well as type I and type II serine/threonine kinase receptors. Indeed, c-α-Klotho reversed impaired in vitro myogenesis caused by these TGF-βs. Oral administration of Ki26894, a small-molecule inhibitor of type I receptors for these TGF-βs, restored muscle atrophy and weakness in α-Klotho (-/-) mice and in elderly wild-type mice by suppression of activated Smad2 and up-regulated Cdkn1a (p21) transcript, a target of phosphorylated Smad2. Ki26894 also induced the slow to fast myofiber switch. These findings show c-α-Klotho's potential as a circulating inhibitor counteracting TGF-β-induced sarcopenia. These data highlight the potential of a novel therapy involving TGF-β blockade to prevent sarcopenia.

    DOI: 10.1016/j.ajpath.2023.01.009

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  • A pilot study on nitration/dysfunction of NK1 segment of myogenic stem cell activator HGF

    Elgaabari, A; Imatomi, N; Kido, H; Seki, M; Tanaka, S; Matsuyoshi, Y; Nakashima, T; Sawano, S; Mizunoya, W; Suzuki, T; Nakamura, M; Anderson, JE; Tatsumi, R

    BIOCHEMISTRY AND BIOPHYSICS REPORTS   31   101295   2022.9   ISSN:2405-5808

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    Protein tyrosine residue (Y) nitration, a post-translational chemical-modification mode, has been associated with changes in protein activity and function; hence the accumulation of specific nitrated proteins in tissues may be used to monitor the onset and progression of pathological disorders. To verify the possible impact of nitration on postnatal muscle growth and regeneration, a pilot study was designed to examine the nitration/dysfunction of hepatocyte growth factor (HGF), a key ligand that is released from the extracellular tethering and activates myogenic stem satellite cells to enter the cell cycle upon muscle stretch and injury. Exposure of recombinant HGF (a hetero-dimer of α- and β-chains) to peroxynitrite induces Y nitration in HGF α-chain under physiological conditions. Physiological significance of this finding was emphasized by Western blotting that showed the NK1 segment of HGF (including a K1 domain critical for signaling-receptor c-met binding) undergoes nitration with a primary target of Y198. Peroxynitrite treatment abolished HGF-agonistic activity of the NK1 segment, as revealed by in vitro c-met binding and bromodeoxyuridine-incorporation assays. Importantly, direct-immunofluorescence microscopy of rat lower hind-limb muscles from two aged-groups (2-month-old “young” and 12-month-old “retired/adult”) provided in vivo evidence for age-related nitration of extracellular HGF (Y198). Overall, findings provide the insight that HGF/NK1 nitration/dysfunction perturbs myogenic stem cell dynamics and homeostasis; hence NK1 nitration may stimulate progression of muscular disorders and diseases including sarcopenia.

    DOI: 10.1016/j.bbrep.2022.101295

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  • Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1. International journal

    Koichi Ojima, Masahiro Kigaki, Emi Ichimura, Takahiro Suzuki, Ken Kobayashi, Susumu Muroya, Takanori Nishimura

    American journal of physiology. Cell physiology   323 ( 2 )   C520 - C535   2022.8   ISSN:0363-6143 eISSN:1522-1563

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    Skeletal muscle consists of slow and fast myofibers in which different myosin isoforms are expressed. Approximately 300 myosins form a single thick filament in the myofibrils, where myosin is continuously exchanged. However, endogenous slow and fast myosin dynamics have not been fully understood. To elucidate those dynamics, here we generated mice expressing green fluorescence protein-tagged slow myosin heavy chain (GFP-Myh7) and Kusabira Orange fluorescence protein-tagged fast myosin heavy chain (KuO-Myh1). First, these mice enabled us to distinguish between GFP- and KuO-myofibers under fluorescence microscopy: GFP-Myh7 and KuO-Myh1 were exclusively expressed in slow myofibers and fast myofibers, respectively. Next, to monitor endogenous myosin dynamics, fluorescence recovery after photobleaching (FRAP) was conducted. The mobile fraction (Mf) of GFP-Myh7 and that of KuO-Myh1 were almost constant values independent of the regions of the myofibers and the muscle portions where the myofibers were isolated. Intriguingly, proteasome inhibitor treatment significantly decreased the Mf in GFP-Myh7 but not in KuO-Myh1 myofibers, indicating that the response to a disturbance in protein turnover depended on muscle fiber type. Taken together, the present results indicated that the mice we generated are promising tools not only for distinguishing between GFP- and KuO-myofibers but also for studying the dynamics of endogenous myosin isoforms by live-cell fluorescence imaging.

    DOI: 10.1152/ajpcell.00415.2021

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  • Connexin 43 is Localized in Gizzard Smooth Muscle Cells during Chicken Development

    Tokunaga Kosuke, Akimoto Shota, Aiba Machiko, Nakagomi Mutsuki, Suzuki Takahiro, Tatsumi Ryuichi, Nakamura Mako

    The Journal of Poultry Science   59 ( 4 )   338 - 347   2022   ISSN:13467395 eISSN:13490486

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    <p>Smooth muscle cells are widely distributed in the digestive organs of chickens. They exist as single cells, but adhere to each other to function synchronously. In this study, the expression of the gap junction protein connexin 43 (Cx43) in chicken gizzards was investigated at embryonic days (E) 10, E15, and E18. Gizzards have an abundance of smooth muscle cells because of their thick muscle layers, which enable easy analysis of the cells. Morphological observations and expression patterns of smooth muscle markers were confirmed. Next, we observed where the markers were localized in the gizzard tissue at E10, E15, and E18. Finally, the expression pattern of Cx43 in primary cultured smooth muscle cells from E15 gizzards was investigated. The analysis revealed the expression and localization of Cx43 and calponin 1 in the smooth muscle layers, and 3D analysis revealed dynamic changes in the localization pattern of Cx43 from E10 to E15. Cultured smooth muscle cells confirmed that Cx43 was expressed in the cell membrane and cytosol. In conclusion, Cx43 expression was identified in chicken gizzards at E10, E15, and E18, which was localized differently during development. The expression was broad at E10, and became restricted at E15 and E18. Primary culture of smooth muscle cells showed that Cx43 was present in the cell membrane and cytosol. This suggests that Cx43 is actively translated into the cytosol at E10, forming a hexamer, and shuttling the cell membrane to function as a gap junction.</p>

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  • The ubiquitin ligase Ozz decreases the replacement rate of embryonic myosin in myofibrils Reviewed

    Emi Ichimura, Koichi Ojima, Susumu Muroya, Takahiro Suzuki, Ken Kobayashi, Takanori Nishimura

    Physiological Reports   9 ( 17 )   2021.9

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    DOI: 10.14814/phy2.15003

  • Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1 Reviewed International journal

    Alaa Elgaabari, Atsuko Miyawaki-Kuwakado, Kosuke Tomimatsu, Qianmei Wu, Kosuke Tokunaga, Wakana Izumi, Takahiro Suzuki, Ryuichi Tatsumi, Mako Nakamura

    The Journal of Biochemistry   2021.3

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    <title>Abstract</title>
    Although skeletal muscle cells and adipocytes are derived from the same mesoderm, they do not transdifferentiate in vivo and are strictly distinct at the level of gene expression. To elucidate some of the regulatory mechanisms underlying this strict distinction, Pax7, a myogenic factor, was ectopically expressed in 3T3-L1 adipose progenitor cells to perturb their adipocyte differentiation potential. Transcriptome analysis showed that ectopic expression of Pax7 repressed the expression of some adipocyte genes and induced expression of some skeletal muscle cell genes. We next profiled the epigenomic state altered by Pax7 expression using H3K27ac, an activating histone mark, and H3K27me3, a repressive histone mark, as indicators. Our results show that ectopic expression of Pax7 did not result in the formation of H3K27ac at loci of skeletal muscle-related genes, but instead resulted in the formation of H3K27me3 at adipocyte-related gene loci. These findings suggest that the primary function of ectopic Pax7 expression is the formation of H3K27me3, and muscle gene expression results from secondary regulation.

    DOI: 10.1093/jb/mvab030

  • Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells Reviewed International journal

    Yusaku Tsugami, Haruka Wakasa, Manabu Kawahara, Atsushi Watanabe, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Cell and Tissue Research   2021.1

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    DOI: 10.1007/s00441-020-03344-0

  • Suppressive effects of curcumin on milk production without inflammatory responses in lactating mammary epithelial cells Reviewed International journal

    Ken Kobayashi, Yusaku Tsugami, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimura

    Phytomedicine   80   153360 - 153360   2021.1

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    DOI: 10.1016/j.phymed.2020.153360

  • Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro Reviewed International journal

    Norihiro Suzuki, Yusaku Tsugami, Haruka Wakasa, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Molecular Nutrition & Food Research   64 ( 24 )   2000853 - 2000853   2020.12

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    DOI: 10.1002/mnfr.202000853

  • Distinct Expression Patterns of Fibrillar Collagen Types I, III, and V in Association with Mammary Gland Remodeling during Pregnancy, Lactation and Weaning Reviewed International journal

    Shiori Tsutsui, Haruka Wakasa, Yusaku Tsugami, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Journal of Mammary Gland Biology and Neoplasia   25 ( 3 )   219 - 232   2020.9

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    DOI: 10.1007/s10911-020-09457-0

  • Regulatory Effects of Soy Isoflavones and Their Metabolites in Milk ProductionviaDifferent Ways in Mice Reviewed International journal

    Yusaku Tsugami, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Journal of Agricultural and Food Chemistry   68 ( 21 )   5847 - 5853   2020.5

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    DOI: 10.1021/acs.jafc.0c01288

  • Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts Reviewed International journal

    Naomi Watanabe, Yusuke Komiya, Yusuke Sato, Yusuke Watanabe, Takahiro Suzuki, Keizo Arihara

    Biochemical and Biophysical Research Communications   525 ( 2 )   406 - 411   2020.4

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    DOI: 10.1016/j.bbrc.2020.02.099

  • Establishment of an in vitro culture model to study milk production and the blood–milk barrier with bovine mammary epithelial cells Reviewed International journal

    Yusaku Tsugami, Norihiro Suzuki, Manabu Kawahara, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Animal Science Journal   91 ( 1 )   2020.3

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    DOI: 10.1111/asj.13355

  • Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro. Reviewed International journal

    Kobayashi, K., Tsugami, Y., Suzuki, N., Suzuki, T., and Nishimura, T.

    Toxicology in Vitro   63   104741   2020.3

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    DOI: 10.1016/j.tiv.2019.104741

  • Adverse Effects of Coumestrol and Genistein on Mammary Morphogenesis and Future Milk Production Ability of Mammary Epithelial Cells Reviewed International journal

    Aogu Kumai, Yusaku Tsugami, Haruka Wakasa, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Advanced Biosystems   4 ( 4 )   1900187 - 1900187   2020.2

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    DOI: 10.1002/adbi.201900187

  • Distinct expression patterns of aquaporin 3 and 5 in ductal and alveolar epithelial cells in mouse mammary glands before and after parturition Reviewed International journal

    Yoshiki Kaihoko, Yusaku Tsugami, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    Cell and Tissue Research   380 ( 3 )   513 - 526   2020.1

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    DOI: 10.1007/s00441-020-03168-y

  • IL-1β directly inhibits milk lipid production in lactating mammary epithelial cells concurrently with enlargement of cytoplasmic lipid droplets. Reviewed International journal

    Matsunaga K, Tsugami Y, Kumai A, Suzuki T, Nishimura T, Kobayashi K

    Experimental cell research   370 ( 2 )   365 - 372   2018.9

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    IL-1β directly inhibits milk lipid production in lactating mammary epithelial cells concurrently with enlargement of cytoplasmic lipid droplets.

    DOI: 10.1016/j.yexcr.2018.06.038

  • HSP90 modulates the myosin replacement rate in myofibrils. Reviewed International journal

    Ojima, K, Ichimura, E, Suzuki, T, Oe, M, Muroya, S, Nishimura, T

    American Journal of Physiology-Cell Physiology   315 ( 1 )   C104 - C114   2018.7

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    HSP90 modulates 1 the myosin replacement rate in myofibrils.

    DOI: 10.1152/ajpcell.00245.2017

  • Moderate High Temperature Condition Induces the Lactation Capacity of Mammary Epithelial Cells Through Control of STAT3 and STAT5 Signaling Reviewed International journal

    Ken Kobayashi, Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Takahiro Nishimura

    Journal of Mammary Gland Biology and Neoplasia   23 ( 1-2 )   75 - 88   2018.6

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    DOI: 10.1007/s10911-018-9393-3

  • 食品としての油脂が骨格筋の代謝特性へ与える影響と筋線維タイプとの関連 Reviewed International journal

    小宮佑介, 丸山アレクサンデル, 渡辺裕介, 内田直愛, 大津翔平, 小林千亜暉, 横山壱成, 鈴木貴弘, 中村真子, 辰巳隆一, 池内義秀, 水野谷航, 有原圭三

    栄養生理研究会報   62 ( 1 )   9 - 17   2018.4

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    Study of dietary fat and skeletal muscle fiber type.

  • Fluorescence microscopy data on expression of Paired Box Transcription Factor 7 in skeletal muscle of APOBEC2 knockout mice Reviewed International journal

    Hideaki Ohtsubo, Yusuke Sato, Yuji Matsuyoshi, Takahiro Suzuki, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi

    Data in Brief   17   1348 - 1351   2018.4

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    The data presented in this article are related to the research articles entitled “APOBEC2 negatively regulates myoblast differentiation in muscle regeneration” and “Data supporting possible implication of APOBEC2 in self-renewal functions of myogenic stem satellite cells: toward understanding the negative regulation of myoblast differentiation” (Ohtsubo et al., 2017a, 2017b) [1,2]. This article provides in vivo phenotypical data to show that Paired Box Transcription Factor 7 (Pax7)-positive cell number (per myofiber) is significantly lower in APOBEC2 (a member of apoB mRNA editing enzyme, catalytic polypeptide-like family)-knockout muscle than the control wild-type tissue at the same age of 8-wk-old in mice. The emerging results support an essential role for APOBEC2 in the self-renewal functions of myogenic stem satellite cells, namely the re-establishment of quiescent status after activation and proliferation of myoblasts.

    DOI: 10.1016/j.dib.2018.02.063

  • Phytoestrogens Weaken the Blood-Milk Barrier in Lactating Mammary Epithelial Cells by Affecting Tight Junctions and Cell Viability Reviewed International journal

    Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   65 ( 50 )   11118 - 11124   2017.12

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    During lactation, mammary epithelial cells (MECs) form the blood-milk barrier by less-permeable tight junctions (TJs) to prevent the leakage of milk components. Phytoestrogens affect the proliferation, differentiation, and apoptosis of MECs. However, it remains unclear whether phytoestrogens are involved in the blood-milk barrier. Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, and daidzein) by using an in vitro mouse-MEC-culture model. The results showed that coumestrol and genistein changed the expression of TJ proteins (claudins-3 and -4 and occludin), weakened barrier function, and reduced beta-casein production. Daidzein also weakened barrier function without inhibiting beta-casein production. Additionally, coumestrol and genistein induced apoptosis in MECs. These results indicate that phytoestrogens weaken the blood-milk barrier by directly affecting TJs and the cellular viability of lactating MECs in different ways.

    DOI: 10.1021/acs.jafc.7b04786

  • Myosin substitution rate is affected by the amount of cytosolic myosin in cultured muscle cells Reviewed International journal

    Koichi Ojima, Emi Ichimura, Yuya Yasukawa, Mika Oe, Susumu Muroya, Takahiro Suzuki, Jun-ichi Wakamatsu, Takanori Nishimura

    ANIMAL SCIENCE JOURNAL   88 ( 11 )   1788 - 1793   2017.11

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    In striated muscles, approximately 300 myosin molecules form a single thick filament in myofibrils. Each myosin is continuously displaced by another myosin to maintain the thick filament structure. Our previous study using a fluorescence recovery after photobleaching (FRAP) technique showed that the myosin replacement rate is decreased by inhibition of protein synthesis, but myosin is still exchangeable. This result prompted us to examine whether myosin in the cytoplasm is involved in myosin replacement in myofibrils. To address this, FRAP was measured in green fluorescent protein (GFP)-tagged myosin heavy chain 3 (Myh3) expressing myotubes that were treated with streptolysin-O (SLO), which forms pores specifically in the plasma membrane to induce leakage of cytoplasmic proteins. Our biochemical data demonstrated that the cytoplasmic myosin content was reduced in SLO-permeabilized semi-intact myotubes. Furthermore, FRAP experiments showed a sluggish substitution rate of GFP-Myh3 in SLO-permeabilized myotubes. Taken together, these results demonstrate that the myosin substitution rate is significantly reduced by a decreased amount of myosin in the cytoplasm and that cytoplasmic myosin contributes to myosin replacement in myofibrils.

    DOI: 10.1111/asj.12826

  • Isoflavones and their metabolites influence the milk component synthesis ability of mammary epithelial cells through prolactin/STAT5 signaling Reviewed International journal

    Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Takanori Nishimura, Ken Kobayashi

    MOLECULAR NUTRITION & FOOD RESEARCH   61 ( 10 )   1700156   2017.10

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    Scope: Isoflavones are a class of polyphonic compounds present in legumes and are called phytoestrogens because of their estrogen-like activity. Estrogen influences the behavior of mammary epithelial cells (MECs) during pregnancy and lactation. In this study, we investigated the direct influences of isoflavones and their metabolites in milk production ability of MECs.
    Methods and results: Mouse MECs were cultured with prolactin and dexamethasone (glucocorticoid analog) to induce milk production ability. Subsequently, lactating MECs were treated with each isoflavone. Coumestrol, biochanin A, genistein, and formononetin decreased the intracellular and secreted beta-casein. On the other hand, p-ethylphenol, daidzein, and equol did not significantly influence beta-casein production at any concentration. Coumestrol, biochanin A and genistein down-regulated the mRNA expression of whey acidic protein (WAP), lactoferrin and alpha-lactalbumin. In contrast, p-ethylphenol, daidzein and equol up-regulated beta-casein and/or WAP with alpha-lactalbumin. Furthermore, coumestrol and genistein down-regulated the expression of prolactin receptor and signal transducer and activator of transcription 5 (STAT5) accompanied by a decrease in STAT5 phosphorylation.
    Conclusion: Isoflavones and their metabolites influence the milk production ability of MECs through different interactions with prolactin/STAT5 signaling. Simultaneous intake of multiple isoflavones by consumption of legumes may induce promotive or adverse effects on lactating MECs.

    DOI: 10.1002/mnfr.201700156

  • The role of semaphorin3A in myogenic regeneration and the formation of functional neuromuscular junctions on new fibres Reviewed International journal

    Judy E. Anderson, Mai-Khoi Q. Do, Nasibeh Daneshvar, Takahiro Suzuki, Junio Dort, Wataru Mizunoya, Ryuichi Tatsumi

    BIOLOGICAL REVIEWS   92 ( 3 )   1389 - 1405   2017.8

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    Current research on skeletal muscle injury and regeneration highlights the crucial role of nerve-muscle interaction in the restoration of innervation during that process. Activities of muscle satellite or stem cells, recognized as the 'currency' of myogenic repair, have a pivotal role in these events, as shown by ongoing research. More recent investigation of myogenic signalling events reveals intriguing roles for semaphorin3A (Sema3A), secreted by activated satellite cells, in the muscle environment during development and regeneration. For example, Sema3A makes important contributions to regulating the formation of blood vessels, balancing bone formation and bone remodelling, and inflammation, and was recently implicated in the establishment of fibre-type distribution through effects on myosin heavy chain gene expression. This review highlights the active or potential contributions of satellite-cell-derived Sema3A to regulation of the processes of motor neurite ingrowth into a regenerating muscle bed. Successful restoration of functional innervation during muscle repair is essential; this review emphasizes the integrative role of satellite-cell biology in the progressive coordination of adaptive cellular and tissue responses during the injury-repair process in voluntary muscle.

    DOI: 10.1111/brv.12286

  • Data supporting possible implication of APOBEC2 in self-renewal functions of myogenic stem satellite cells: Toward understanding the negative regulation of myoblast differentiation Reviewed International journal

    Hideaki Ohtsubo, Yusuke Sato, Takahiro Suzuki, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi

    Data in Brief   12   269 - 273   2017.6

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    This paper provides in vitro phenotypical data to show that APOBEC2, a member of apoB mRNA editing enzyme, catalytic polypeptide-like family, may implicate in self-renewal functions of myogenic stem satellite cells, namely in the re-establishment of quiescent status after activation and proliferation of myoblasts in single-myofiber culture.

    DOI: 10.1016/j.dib.2017.03.051

  • APOBEC2 negatively regulates myoblast differentiation in muscle regeneration Reviewed International journal

    Hideaki Ohtsubo, Yusuke Sato, Takahiro Suzuki, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi

    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY   85   91 - 101   2017.4

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    Recently we found that the deficiency of APOBEC2, a member of apoB mRNA editing enzyme, catalytic polypeptide-like family, leads to a diminished muscle mass and increased myofiber with centrally-located nuclei known as dystrophic phenotypes. APOBEC2 expression is predominant in skeletal and cardiac muscles and elevated exclusively at the early-differentiation phase of wild-type (WT) myoblast cultures; however the physiological significance is still un-known. Here we show that APOBEC2 is a key negative regulator of myoblast differentiation in muscle regeneration. APOBEC2-knockout (A2KO) mice myoblast cultures displayed a normal morphology of primary myotubes along with earlier increase in fusion index and higher expression levels of myosin heavy chain (MyHC), myogenin and its cooperating factor MEF2C than WT myoblasts. Similar response was observable in APOBEC2-knockdown cultures of WT myoblasts that were transfected with the specific siRNA at the differentiation phase (not proliferation phase). Importantly, cardiotoxin-injured A2KO gastrocnemius muscle provided in vivo evidence by showing larger up-regulation of neonatal MyHC and myogenin and hence earlier regeneration of myofiber structures with diminished cross-sectional areas and minimal Feret diameters. Therefore, the findings highlight a promising role for APOBEC2 in normal progression of regenerative myogenesis at the early-differentiation phase upon muscle injury. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bioce1.2017.02.005

  • Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: Impact of the low-dose supplementation Reviewed International journal

    Wataru Mizunoya, Shinpei Okamoto, Hideo Miyahara, Mariko Akahoshi, Takahiro Suzuki, Mai-Khoi Q. Do, Hideaki Ohtsubo, Yusuke Komiya, Mulan Qahar, Toshiaki Waga, Koichi Nakazato, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi

    ANIMAL SCIENCE JOURNAL   88 ( 3 )   489 - 499   2017.3

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    Our previous studies demonstrated that an 8-week intake of 5% (w/w) apple polyphenol (APP) in the diet improves muscle endurance of young-adult rats. In order to identify a lower limit of the dietary contribution of APP to the effect, the experiments were designed for lower-dose supplementation (8-week feeding of 0.5% APP in AIN-93G diet) to 12-week-old male Sprague-Dawley rats. Results clearly showed that the 0.5% APP diet significantly up-regulates slower myosin-heavy-chain (MyHC) isoform ratios (IIx and IIa relative to total MyHC) and myoglobin expression in lower hind-limb muscles examined (P<0.05). There was a trend to increased fatigue resistance detected from measurements of relative isometric plantar-flexion force torque generated by a stimulus train delivered to the tibial nerve (F(98, 1372)=1.246, P=0.0574). Importantly, there was no significant difference in the animal body-phenotypes or locomotor activity shown as total moving distance in light and dark periods. Therefore, the present study encourages the notion that even low APP-intake may increase the proportions of fatigue-resistant myofibers, and has promise as a strategy for modifying performance in human sports and improving function in age-related muscle atrophy.

    DOI: 10.1111/asj.12655

  • Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells. Reviewed International journal

    Kobayashi, K, Oyama, S, Kuki, C, Tsugami, Y, Matsunaga, K, Suzuki, T, Nishimura, T

    Molecular and Cellular Endocrinology   440 ( C )   16 - 24   2017.1

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    Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in beta-casein secretion pathway in lactating mammary epithelial cells
    Beta-casein is a secretory protein contained in milk. Mammary epithelial cells (MECs) synthesize and secrete beta-casein during lactation. However, it remains unclear how the beta-casein secretion pathway is developed after parturition. In this study, we focused on prolactin (PRL), epidermal growth factor (EGF), and glucocorticoids, which increase in blood plasma and milk around parturition. MECs cultured with PRL, EGF and dexamethasone (DEX: glucocorticoid analog) developed the beta-casein secretion pathway. In the absence of PRL, MECs hardly expressed beta-casein. EGF enhanced the expression and secretion of beta-casein in the presence of PRL and DEX. DEX treatment rapidly increased secreted beta-casein concurrent with enhancing beta-casein expression. DEX also up-regulated the expression of SNARE proteins, such as SNAP-23, VAMP-8 and Syntaxin-12. Furthermore, PRL and DEX regulated the expression ratio of alpha(st-), beta- and kappa-casein. These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.mce.2016.11.006

  • Experiments reveal a novel mechanism to regulate myofiber types and its activation by functional food ingredients. Reviewed

    辰巳隆一, 鈴木貴弘, 大屋雄暉, ド クイ マイコイ, 大坪秀明, 川口舞, アンダーソン ジュディー, 水野谷航, 小宮佑介, チャハラ モクラン, 尾嶋孝一, 澤野祥子, 中村真子, 古瀬充宏, 池内義秀, アレン ロナルド, 巳隆一, 鈴木貴弘, 大屋雄暉, ド クイ マイコイは等しい

    栄養生理研究会報   60 ( 2 )   69 - 77   2016.7

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    Experiments reveal a novel mechanism to regulate myofiber types and its activation by functional food ingredients.

  • miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells (vol 16, 13, 2015) Reviewed International journal

    Naoki Katase, Kumiko Terada, Takahiro Suzuki, Shin-ichiro Nishimatsu, Tsutomu Nohno

    BMC CELL BIOLOGY   17 ( 1 )   9   2016.3

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    DOI: 10.1186/s12860-016-0083-y

  • Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts International journal

    Mai-Khoi Q. Do, Naomi Shimizu, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Shoko Sawano, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi

    Physiological Reports   3 ( 9 )   e12553 - e12553   2015.9

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    DOI: 10.14814/phy2.12553

  • Improvement of Endurance Based on Muscle Fiber-Type Composition by Treatment with Dietary Apple Polyphenols in Rats Reviewed International journal

    Wataru Mizunoya, Hideo Miyahara, Shinpei Okamoto, Mariko Akahoshi, Takahiro Suzuki, Mai-Khoi Q. Do, Hideaki Ohtsubo, Yusuke Komiya, Mu Lan, Toshiaki Waga, Akira Iwata, Koichi Nakazato, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi

    PLOS ONE   10 ( 7 )   e0134303   2015.7

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    A recent study demonstrated a positive effect of apple polyphenol (APP) intake on muscle endurance of young-adult animals. While an enhancement of lipid metabolism may be responsible, in part, for the improvement, the contributing mechanisms still need clarification. Here we show that an 8-week intake of 5% (w/w) APP in the diet, up-regulates two features related to fiber type: the ratio of myosin heavy chain (MyHC) type IIx/IIb and myoglobin protein expression in plantaris muscle of 9-week-old male Fischer F344 rats compared to pair-fed controls (P < 0.05). Results were demonstrated by our SDS-PAGE system specialized for MyHC isoform separation and western blotting of whole muscles. Animal-growth profiles (food intake, body-weight gain, and internal-organ weights) did not differ between the control and 5% APP-fed animals (n = 9/group). Findings may account for the increase in fatigue resistance of lower hind limb muscles, as evidenced by a slower decline in the maximum isometric planter-flexion torque generated by a 100-s train of electrical stimulation of the tibial nerve. Additionally, the fatigue resistance was lower after 8 weeks of a 0.5% APP diet than after 5% APP, supporting an APP-dose dependency of the shift in fiber-type composition. Therefore, the present study highlights a promising contribution of dietary APP intake to increasing endurance based on fiber-type composition in rat muscle. Results may help in developing a novel strategy for application in animal sciences, and human sports and age-related health sciences.

    DOI: 10.1371/journal.pone.0134303

  • Supplementary immunocytochemistry of hepatocyte growth factor production in activated macrophages early in muscle regeneration Reviewed International journal

    Shoko Sawano, Takahiro Suzuki, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Yoshihide Ikeuchi, Ryuichi Tatsumi

    ANIMAL SCIENCE JOURNAL   85 ( 12 )   994 - 1000   2014.12

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    Regenerative intramuscular motor-innervation is thought to reside in the spatiotemporal expression of axon-guidance molecules. Our previous studies showed that resident myogenic stem cells, satellite cells, up-regulate a secreted neural-chemorepellent semaphorin 3A (Sema3A) during the early-differentiation period, in response to hepatocyte growth factor (HGF) elevated in injured muscle. However, a paracrine source of the HGF release is still unknown. Very recently, we proposed a possible contribution of anti-inflammatory macrophages (CD206-positive M2) by showing that M2 cells infiltrate predominantly at the early-differentiation phase (3-5 days post-injury) and produce/secrete large amounts of HGF. However, in understanding this concept there still remains a critical need to examine if phagocytotic pro-inflammatory macrophages (CD86-positive M1), another activated-phenotype still present at the early-differentiation phase concerned, produce HGF upon muscle injury. The current immunocytochemical study demonstrated that the HGF expression is negative for M1 prepared from cardiotoxin-injured Tibialis anterior muscle at day 5, in contrast to the intense fluorescent-signal of M2 served as a positive control. This supplementary result advances our understanding of a spatiotemporal burst of HGF secretion from M2 populations (not M1) to impact Sema3A expression, which ensures a coordinated delay in attachment of motoneuron terminals onto damaged and generating fibers during the early phase of muscle regeneration.

    DOI: 10.1111/asj.12264

  • Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: Promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle Reviewed International journal

    Shohei Sakaguchi, Jun-ichi Shono, Takahiro Suzuki, Shoko Sawano, Judy E. Anderson, Mai-Khoi Q. Do, Hideaki Ohtsubo, Wataru Mizunoya, Yusuke Sato, Mako Nakamura, Mitsuhiro Furuse, Koji Yamada, Yoshihide Ikeuchi, Ryuichi Tatsumi

    The International Journal of Biochemistry & Cell Biology   54   272 - 285   2014.9

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    DOI: 10.1016/j.biocel.2014.05.032

  • 筋幹細胞が分泌するSema3Aによる筋線維型自律制御機構 Reviewed

    鈴木貴弘, 大屋雄暉, 尾嶋孝一, 大坪秀明, 小宮佑介, 水野谷航, 中村真子, 池内義秀, 古瀬充宏, 辰巳隆一

    栄養生理研究会報   58 ( 1 )   19 - 25   2014.4

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    Autonomous determination of muscle fiber-types by semaphorin 3A secreted from resident myogenic stem cells.

  • Preliminary time-course study of antiinflammatory macrophage infiltration in crush-injured skeletal muscle Reviewed International journal

    Jun-ichi Shono, Shohei Sakaguchi, Takahiro Suzuki, Mai-Khoi Q. Do, Wataru Mizunoya, Mako Nakamura, Yusuke Sato, Mitsuhiro Furuse, Koji Yamada, Yoshihide Ikeuchi, Ryuichi Tatsumi

    Animal Science Journal   84 ( 11 )   744 - 750   2013.11

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    Muscle damage induces massive macrophage infiltration of the injury site, in which activated pro-inflammatory and anti-inflammatory phenotypes (currently classified as M1 and M2, respectively) have been documented as distinct functional populations predominant at different times after the conventional acute injury by intramuscular injection of snake venoms (cardiotoxin, notexin) or chemicals (bupivacaine hydrochloride, barium chloride). The present study employed a muscle-crush injury model that may better reflect the physiologic damage and repair processes initiated by contusing a gastrocnemius muscle in the lower hind-limb of adult mice with hemostat forceps, and examined the time-course invasion of M1 and M2 macrophages during muscle regeneration by immunocytochemistry of CD197 and CD206 marker proteins. CD197-positive M1 macrophages were observed exclusively at 1-4 days after crush followed by the alternative prevalence of CD206-positive M2 at 7 days of myogenic differentiation, characterized by increasing levels of myogenin messenger RNA expression. Preliminary PCR analysis showed that M2 may produce hepatocyte growth factor (HGF) in culture, providing additional benefit to understanding that M2 populations actively promote regenerative myogenesis (muscle fiber repair) and moto-neuritogenesis (re-attachment of motoneuron terminals onto damaged fibers) through their time-specific infiltration and release of growth factor at the injury site early in muscle regeneration. © 2013 Japanese Society of Animal Science.

    DOI: 10.1111/asj.12105

  • Satellite cells produce neural chemorepellent semaphorin 3A upon muscle injury Reviewed International journal

    Yusuke SATO, Mai-Khoi Q. DO, Takahiro SUZUKI, Hideaki OHTSUBO, Wataru MIZUNOYA, Mako NAKAMURA, Mitsuhiro FURUSE, Yoshihide IKEUCHI, Ryuichi TATSUMI

    Animal Science Journal   84 ( 2 )   185 - 189   2013.2

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    DOI: 10.1111/asj.12014

  • Time-coordinated prevalence of extracellular HGF, FGF2 and TGFβ3 in crush-injured skeletal muscle. Reviewed International journal

    Do, M-KQ, Suzuki, T, Gerelt, B, Sato, Y, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, JE, Tatsumi, R

    Animal Science Journal   83 ( 10 )   712 - 717   2012.10

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    Time-coordinated prevalence of extracellular HGF, FGF2 and TGF-ss 3 in crush-injured skeletal muscle
    Successful regeneration and remodeling of neuromuscular junctions are critical for restoring functional capacities and properties of skeletal muscle after damage, and axon-guidance molecules may be involved in the signaling that regulates such restoration. Recently, we found that early-differentiated satellite cells up-regulate a secreted neural chemorepellent Sema3A upon in vivo muscle-crush injury. The study also revealed that Sema3A expression is up-regulated in primary satellite-cell cultures in response to hepatocyte growth factor (HGF) and basic fibroblast growth factor (FGF2) and is prevented by transforming growth factor (TGF)-beta 2, 3. In order to verify the physiological significance of this regulation in vitro, the present study was designed to estimate the time-course of extracellular HGF, FGF2 and TGF-beta 3 concentrations after crush-injury of Gastrocnemius muscle in the rat lower hind-limb, using a combination of a non-homogenization/non-spin extraction of extracellular wound fluids and enhanced chemiluminescenceWestern blotting analyses. Results clearly demonstrated that active HGF and FGF2 are prevalent in 28?days post-crush, whereas active TGF-beta 3 increases after 12?days, providing a better understanding of the time-coordinated levels of HGF, FGF2 and TGF-beta 3 that drive regulation of Sema3A expression during regenerative intramuscular moto-neuritogenesis.

    DOI: 10.1111/j.1740-0929.2012.01057.x

  • Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch Reviewed International journal

    Minako Hara, Kuniko Tabata, Takahiro Suzuki, Mai-Khoi Q. Do, Wataru Mizunoya, Mako Nakamura, Shotaro Nishimura, Shoji Tabata, Yoshihide Ikeuchi, Kenji Sunagawa, Judy E. Anderson, Ronald E. Allen, Ryuichi Tatsumi

    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   302 ( 12 )   C1741 - C1750   2012.6

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    Hara M, Tabata K, Suzuki T, Do MQ, Mizunoya W, Nakamura M, Nishimura S, Tabata S, Ikeuchi Y, Sunagawa K, Anderson JE, Allen RE, Tatsumi R. Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch. Am J Physiol Cell Physiol 302: C1741-C1750, 2012. First published March 28, 2012; doi:10.1152/ajpcell.00068.2012.-When skeletal muscle is stretched or injured, satellite cells, resident myogenic stem cells positioned beneath the basal lamina of mature muscle fibers, are activated to enter the cell cycle. This signaling pathway is a cascade of events including calcium-calmodulin formation, nitric oxide (NO) radical production by NO synthase, matrix metalloproteinase activation, release of hepatocyte growth factor (HGF) from the extracellular matrix, and presentation of HGF to the receptor c-met, as demonstrated by assays of primary cultures and in vivo experiments. Here, we add evidence that two ion channels, the mechanosensitive cation channel (MS channel) and the long-lasting-type voltage-gated calcium-ion channel (L-VGC channel), mediate the influx of extracellular calcium ions in response to cyclic stretch in satellite cell cultures. When applied to 1-h stretch cultures with individual inhibitors for MS and L-VGC channels (GsMTx-4 and nifedipine, respectively) or with a less specific inhibitor (gadolinium chloride, Gd), satellite cell activation and upstream HGF release were abolished, as revealed by bromodeoxyuridine-incorporation assays and Western blotting of conditioned media, respectively. The inhibition was dose dependent with a maximum at 0.1 mu M (GsMTx-4), 10 mu M (nifedipine), or 100 mu M (Gd) and canceled by addition of HGF to the culture media; a potent inhibitor for transient-type VGC channels (NNC55-0396, 100 mu M) did not show any significant inhibitory effect. The stretch response was also abolished when calcium-chelator EGTA (1.8 mM) was added to the medium, indicating the significance of extracellular free calcium ions in our present activation model. Finally, cation/calcium channel dependencies were further documented by calcium-imaging analyses on stretched cells; results clearly demonstrated that calcium ion influx was abolished by GsMTx-4, nifedipine, and EGTA. Therefore, these results provide an additional insight that calcium ions may flow in through L-VGC channels by possible coupling with adjacent MS channel gating that promotes the local depolarization of cell membranes to initiate the satellite cell activation cascade.

    DOI: 10.1152/ajpcell.00068.2012

  • Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures Reviewed International journal

    Mai-Khoi Q. Do, Yusuke Sato, Naomi Shimizu, Takahiro Suzuki, Jun-ichi Shono, Wataru Mizunoya, Mako Nakamura, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi

    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   301 ( 5 )   C1270 - C1279   2011.11

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    Do MKQ, Sato Y, Shimizu N, Suzuki T, Shono J, Mizunoya W, Nakamura M, Ikeuchi Y, Anderson JE, Tatsumi R. Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures. Am J Physiol Cell Physiol 301: C1270-C1279, 2011. First published August 24, 2011; doi: 10.1152/ajpcell.00257.2011.-Successful regeneration and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory signals of such coordination remain unclear, although axon-guidance molecules may be involved. Recently, satellite cells, resident myogenic stem cells positioned beneath the basal lamina and at high density at the myoneural junction regions of mature fibers, were shown to upregulate a secreted neural chemorepellent semaphorin 3A (Sema3A) in response to in vivo muscle-crush injury. The initial report on that expression centered on the observation that hepatocyte growth factor (HGF), an essential cue in muscle fiber growth and regeneration, remarkably upregulates Sema3A expression in early differentiated satellite cells in vitro [Tatsumi et al., Am J Physiol Cell Physiol 297: C238-C252, 2009]. Here, we address regulatory effects of basic fibroblast growth factor (FGF2) and transforming growth factor (TGF)-beta s on Sema3A expression in satellite cell cultures. When treated with FGF2, Sema3A message and protein were upregulated as revealed by reverse transcription-polymerase chain reaction and immunochemical studies. Sema3A upregulation by FGF2 was dose dependent with a maximum (8- to 1-fold relative to the control) at 2.5 ng/ml (150 pM) and occurred exclusively at the early differentiation stage. The response was highly comparable in dose response and timing to effects of HGF treatment, without any additive or synergistic effect from treatment with a combination of both potent upregulators. In contrast, TGF-beta 2 and -beta 3 potently decreased basal Sema3A expression; the maximum effect was at very low concentrations (40 and 8 pM, respectively) and completely cancelled the activities of FGF2 and HGF to upregulate Sema3A. These results therefore encourage the prospect that a time-coordinated increase in HGF, FGF2, and TGF-beta ligands and their receptors promotes a programmed strategy for Sema3A expression that guarantees successful intramuscular motor reinnervation by delaying sprouting and reattachment of motoneuron terminals onto damaged muscle fibers early in regeneration pending restoration of muscle fiber contractile integrity.

    DOI: 10.1152/ajpcell.00257.2011

  • In vitromeasurement of post-natal changes in proliferating satellite cell frequency during rat muscle growth International journal

    Takahiro SUZUKI, Hideyuki TAKAISHI, Tomowa SAKATA, Mai-Khoi Q. DO, Minako HARA, Akiko SATO, Wataru MIZUNOYA, Takanori NISHIMURA, Akihito HATTORI, Yoshihide IKEUCHI, Ryuichi TATSUMI

    Animal Science Journal   81 ( 2 )   245 - 251   2010.4

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    DOI: 10.1111/j.1740-0929.2009.00734.x

  • Possible implication of satellite cells in regenerative motoneuritogenesis: HGF upregulates neural chemorepellent Sema3A during myogenic differentiation Reviewed International journal

    Ryuichi Tatsumi, Yoriko Sankoda, Judy E. Anderson, Yusuke Sato, Wataru Mizunoya, Naomi Shimizu, Takahiro Suzuki, Michiko Yamada, Robert P. Rhoads, Yoshihide Ikeuchi, Ronald E. Allen

    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   297 ( 2 )   C238 - C252   2009.8

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    Tatsumi R, Sankoda Y, Anderson JE, Sato Y, Mizunoya W, Shimizu N, Suzuki T, Yamada M, Rhoads RP Jr, Ikeuchi Y, Allen RE. Possible implication of satellite cells in regenerative motoneuritogenesis: HGF upregulates neural chemorepellent Sema3A during myogenic differentiation. Am J Physiol Cell Physiol 297: C238-C252, 2009. First published June 10, 2009; doi: 10.1152/ajpcell.00161.2009.-Regenerative coordination and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory mechanisms of such coordination remain unclear, although both attractive and repulsive axon guidance molecules may be involved in the signaling pathway. Here we show that expression of a neural secreted chemorepellent semaphorin 3A (Sema3A) is remarkably upregulated in satellite cells of resident myogenic stem cells that are positioned beneath the basal lamina of mature muscle fibers, when treated with hepatocyte growth factor (HGF), established as an essential cue in muscle fiber growth and regeneration. When satellite cells were treated with HGF in primary cultures of cells or muscle fibers, Sema3A message and protein were upregulated as revealed by reverse transcription-polymerase chain reaction and immunochemical studies. Other growth factors had no inductive effect except for a slight effect of epidermal growth factor treatment. Sema3A upregulation was HGF dose dependent with a maximum (about 7-to 8-fold units relative to the control) at 10-25 ng/ml and occurred exclusively at the early-differentiation stage, as characterized by the level of myogenin expression and proliferation (bromodeoxyuridine incorporation) of the cells. Neutralizing antibody to the HGF-specific receptor, c-met, did not abolish the HGF response, indicating that c-met may not mediate the Sema3A expression signaling. Finally, in vivo Sema3A was upregulated in the differentiation phase of satellite cells isolated from muscle regenerating following crush injury. Overall, the data highlight a heretofore unexplored and active role for satellite cells as a key source of Sema3A expression triggered by HGF, hence suggesting that regenerative activity toward motor innervation may importantly reside in satellite cells and could be a crucial contributor during postnatal myogenesis.

    DOI: 10.1152/ajpcell.00161.2009

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Presentations

  • 分化誘導過程における物理刺激が筋芽細胞の自律的線維型制御に与える影響

    鈴木貴弘

    第10回骨格筋生物学研究会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌医科大学 北海道   Country:Japan  

  • 筋芽細胞で発現するnetrin-1,-4および受容体による分化過程の機能

    鈴木貴弘, 前野岳大, 尾嶋孝一, 小川陽平, 中村真子, 辰巳隆一

    第8回 若手による骨格筋細胞研究会  2024.2 

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    Event date: 2024.2

    Language:Others   Presentation type:Oral presentation (general)  

    Venue:東京医科大学 東京都   Country:Japan  

  • 廃用による筋幹細胞の活性化阻害に関する報告

    桑門想, Alaa Elgaabari, 鈴木貴弘, 川口謙一, 中島康晴, 辰巳隆一

    第7回日本リハビリテーション医学会秋季学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:シーガイアコンベンションセンター 宮崎県   Country:Japan  

  • 筋の肥大や再生に留まらない筋幹細胞の機能 Invited

    鈴木貴弘

    日本畜産学会第131回大会 関連シンポジウム:骨格筋を基礎的な観点から再考する学術フォーラム「骨格筋の量と質を制御する分子機構と畜産学への応用」  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:帯広畜産大学 北海道   Country:Japan  

  • 筋幹細胞活性化因子HGFのニトロ化による不活化に関する研究:抗HGFモノクローナル抗体のニトロ化抑制効果の検証

    田中咲帆, Elgaabari Alaa, 圖師歌歩乃, 澤野祥子, 水野谷航, 松吉祐児, 鈴木貴弘,中村真子, 辰巳隆一

    日本畜産学会 第131回大会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:帯広畜産大学 北海道   Country:Japan  

  • 筋幹細胞で発現するnetrin受容体の筋分化への関与

    前野岳大, 小川陽平, 尾嶋孝一, 中村真子, 辰巳隆一, 鈴木貴弘

    日本畜産学会 第131回大会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:帯広畜産大学 北海道   Country:Japan  

  • 筋芽細胞による自律的な筋線維型制御における機械的伸展刺激の影響

    中田后紀, 川崎佑華, 大山竜輝, 前野岳大, 今給黎燿, 小川陽平, 大崎莉果, 小川蒼生, 保坂善真, 中村真子, 辰巳隆一, 鈴木貴弘

    日本畜産学会 第131回大会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:帯広畜産大学 北海道   Country:Japan  

  • 弾性刺激と電気刺激が筋芽細胞による自律的な筋線維型制御に及ぼす影響

    川崎佑華, 江草愛, 室田大輝, 大山竜輝, 中村真子, 辰巳隆一, 鈴木貴弘

    日本畜産学会 第131回大会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:帯広畜産大学 北海道   Country:Japan  

  • Understanding the mechanism of chicken gizzard contractile/proliferative smooth muscle cells International conference

    Mutsuki Nakagomi, Kosuke Tokunaga, Saki Egashira, Kazuki Hosoda, Machiko Aiba, Takahiro Suzuki, Ryuichi Tatsumi, Mako Nakamura

    11th Avian Model Systems Meeting  2023.9 

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    Event date: 2023.9

    Language:English  

    Venue:Portsmouth   Country:United Kingdom  

  • 筋幹細胞が合成するsemaphorinおよびnetrinサブファミリーの生理機能に関する研究

    鈴木貴弘, 前野岳大, 今給黎耀, 川崎佑華, 中田后紀, 小川陽平, 中村真子, 辰巳隆一

    第9回 日本筋学会学術集会  2023.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンター, 大阪府   Country:Japan  

  • Muscle De-nitration Activity: Regenerative Upregulation in Young, not Old Mice

    Alaa Elgaabari, Sakiho Tanaka, Kahona Zushi, So Kuwakado, Miyumi Seki, Takahiro Suzuki, Mako Nakamura, Ryuichi Tatsumi

    第9回 日本筋学会学術集会  2023.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンター, 大阪府   Country:Japan  

  • オレイン酸摂取はマウス骨格筋において1および2X型筋線維を増加させる

    小宮佑介, 伊関柊吾, 鈴木貴弘, 辰巳隆一, 澤野祥子, 水野谷航, 長竿淳, 有原圭三

    第77回 日本栄養・食糧学会大会  2023.5 

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    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌コンベンションセンター   Country:Japan  

  • 筋幹細胞による自律的な筋線維型制御メカニズムの検証~弾性刺激に着目したアプローチ~

    鈴木貴弘

    第9回骨格筋生物学研究会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東海大学湘南キャンパス(神奈川県平塚市)   Country:Japan  

  • netrin-4とnetrin受容体結合による速筋型の筋管形成への関与

    前野岳大、鈴木貴弘

    第9回骨格筋生物学研究会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東海大学湘南キャンパス(神奈川県平塚市)   Country:Japan  

  • 筋幹細胞活性化因子HGF のニトロ化による不活化に関する研究:ニトロ化を抑制する化合物

    関 美弓, Alaa Elgaabari, 田中咲帆, 澤野祥子, 水野谷航, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会第130回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Other  

  • 骨格筋の部位に準じた衛星細胞の特性を分化誘導過程において比較する

    鈴木貴弘, 村本 匠, 前野岳大, 川崎佑華, 中村真子, 辰巳隆一

    日本畜産学会第130回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Other  

  • 筋幹細胞分泌因子semaphorin3A による筋線維型制御機構:速筋型筋線維の形成抑制機能について

    金子琉輝, 松吉祐児, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会第130回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Other  

  • The muti-potent modulator netrin-1 synthesized in satellite cell-derived myoblasts isolated from the fast-twitch muscle may regulate fast-type myotube formation International conference

    Takahiro Suzuki, Takahiro Maeno, Mako Nakamura and Ryuichi Tatsumi.

    68th International Congress of Meat Science and Technology  2022.8 

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    Event date: 2022.8

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン開催   Country:Other  

  • Netrin-4 synthesized in satellite cell-derived myoblasts regulates myotube formation during myogenic differentiation International conference

    Takahiro Maeno, Yuka Kawasaki, Takumi Muramoto, Mako Nakamura, Ryuichi Tatsumi and Takahiro Suzuki.

    68th International Congress of Meat Science and Technology  2022.8 

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    Event date: 2022.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Other  

  • 物理刺激が筋幹細胞による自律的な筋線維型制御に及ぼす影響 〜培養基質の弾性に着目したアプローチ〜 Invited

    鈴木貴弘

    第24 回日本畜産学会若手企画シンポジウム 若手が考えるこれからのアニマルサイエンス2022  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 発生段階のニワトリ砂嚢平滑筋細胞におけるCx43発現の解析

    徳永亘祐・穐本翔太・饗場万知子・中込睦生・鈴木貴弘・辰巳隆一・中村真子

    日本家禽学会2022年度春季大会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Japan  

  • 野生型マウスの一部系統で筋幹細胞の分化能に機能不全が起こる要因の検証

    鈴木貴弘

    第1回日本畜産学会若手企画オンラインサイエンスキャンプ:若手が切り拓くアニマルサイエンスの最前線  2024.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Japan  

  • 分化型および脱分化型平滑筋細胞におけるギャップ結合因子コネキシン43の発現解析

    中込睦生,徳永亘祐,穐本翔太,饗場万知子,鈴木貴弘,辰巳隆一,中村真子

    日本農芸化学会2022年度(令和4年度)京都大会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催   Country:Japan  

  • 速筋型筋線維に特異的な加齢変化:ECMに結合している筋幹細胞活性化因子HGF のニトロ化・不活化

    辰巳隆一, Elgaabari Alaa, 今冨菜々, 城戸潤力, 中島崇, 奥田晶子, 真鍋宣隆, 澤野祥子, 水野谷航, 関美弓, 松吉祐児, 中村真子, 鈴木貴弘

    第7回 日本筋学会学術集会【ハイブリッド開催】  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Venue:京都大学 百周年時計台記念館   Country:Japan  

  • 筋幹細胞が合成するnetrin-4 は筋管形成を誘導する

    前野岳大, 川崎佑華, 村本匠, 中村真子, 辰巳隆一, 鈴木貴弘

    第7回 日本筋学会学術集会【ハイブリッド開催】  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Venue:京都大学 百周年時計台記念館   Country:Japan  

  • 野生型マウス系統間における衛星細胞の分化・筋管形成能の比較

    鈴木貴弘, 西百合子, 小山大空, 前野岳大, 村本匠, 川崎佑華, 中村真子, 辰巳隆一, 西邑 隆徳

    第7回 日本筋学会学術集会【ハイブリッド開催】  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Country:Japan  

  • 衛星細胞の休止状態を維持する初代培養系の作出を目指して

    江原健史郎, 松吉祐児, Elgaabari Alaa, 中村真子, 鈴木貴弘, 辰巳隆一

    第7回 日本筋学会学術集会【ハイブリッド開催】  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Country:Japan  

  • Nitration and Dysfunction of NK1 Domain of Myogenic Stem Cell Activator HGF

    Elgaabari Alaa, 今冨菜々, 城戸潤力, 松吉祐児, 中島崇, 澤野祥子, 水野谷航, 鈴木貴弘, 中村真子, 辰巳隆一

    第7回 日本筋学会学術集会【ハイブリッド開催】  2021.12 

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    Event date: 2021.12

    Language:English  

    Venue:京都大学 百周年時計台記念館   Country:Japan  

  • Nitration and Dysfunction of NK1 Segment of Myogenic Stem Cell Activator HGF International conference

    Elgaabari, A., Imatomi, N., Kido, H., Matsuyoshi, Y., Nakashima, T., Sawano, S., Mizunoya, W., Suzuki, T., Nakamura, M., Tatsumi, R.

    Cell Bio Virtual 2021-An Online ASCB|EMBO Meeting  2021.12 

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    Event date: 2021.12

    Language:English  

    Country:Japan  

  • 食肉の質を制御する新奇アイデア 〜筋幹細胞に着目したアプローチ〜 Invited

    鈴木貴弘

    令和3年度(2021年度)日本栄養・食糧学会 九州・沖縄支部大会, 特別講演会:「食事タンパク質の未来を考える」  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:九州大学【オンライン開催】   Country:Japan  

  • 分化型平滑筋細胞におけるConnexin43 の機能解析

    饗場万知子, 徳永亘祐, 穐本翔太, 片岩由莉, 中込睦生, 鈴木貴弘, 辰巳隆一, 中村真子

    日本畜産学会 第129回大会【オンライン開催】  2021.9 

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    Event date: 2021.9

    Language:Japanese  

    Country:Japan  

  • 筋幹細胞が担う筋線維型の制御 Invited

    鈴木貴弘

    日本畜産学会 第129回大会, パラレルシンポジウムII: 畜産学における組織幹細胞研究の現在・未来  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学【オンライン開催】   Country:Japan  

  • Insight linking between nitration and myogenic dysfunction of HGF/NK1 domain

    Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Ryuichi Tatsumi

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

    Language:Others  

    Country:Other  

  • 筋線維型評価における上腕二頭筋の有用性についての検証

    松吉祐児, 金子琉輝, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 筋幹細胞活性化因子HGFのニトロ化による不活化の生理学的意義:加齢性筋萎縮・再生不全の主要因のブレークスルー

    今冨菜々, 城戸潤力, Alaa Elgaabari, 中島崇, 澤野祥子, 水野谷航, 松吉祐児, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 筋幹細胞の活性化・増殖因子HGFのニトロ化による不活化の生理学的意義:暑熱ストレスによる筋成長阻害との関係

    増原夏海, Mohamed Z. Elhussiny, Vishwajit, S. Chowdhury, 今冨菜々, Alaa Elgaabari, 城戸潤力, 澤野祥子, 水野谷航, 松吉祐児, 鈴木貴弘, 中村真子, 古瀬充宏, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 筋幹細胞の活性化抑制機構の発見:活性化因子 HGFのニトロ化による生理活性の消失

    城戸潤力, 今冨菜々, Alaa Elgaabari, 奥田晶子, 真鍋宜隆, 中島崇, 澤野祥子, 水野谷航, 松吉祐児, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

    Language:Others  

    Country:Other  

  • 筋幹細胞におけるmyogeninの生理機能を骨格筋種で比較する

    鈴木貴弘, 有松里央, 尾嶋孝一, 中村真子, 辰巳隆一, 小林謙, 西邑隆徳

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 筋幹細胞が合成するnetrin-4の筋線維型制御への関与

    前野岳大, 有松里央, 久枝皓雅, 山谷有希, 小林謙, 中村真子, 西邑隆徳, 辰巳隆一, 鈴木貴弘

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 筋原線維内の太いフィラメントにおけるミオシン分子置換に及ぼすユビキチンリガーゼの影響 (Overexpressed-ubiquitin ligase reduces myosin replacement rate in thick filament of myofibrils.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    市村恵美, 尾嶋孝一, 鈴木貴弘, 小林謙, 西邑隆徳

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 無血清培地を用いたニワトリ砂嚢由来平滑筋細胞の分化維持培養系の確立

    德永亘祐, 饗場万知子, 穐本翔太, 水野谷航, 鈴木貴弘, 辰巳隆一, 中村真子

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 持久的運動負荷による遅筋型筋線維の増加に筋幹細胞は関与しているか?

    荒川拓実, 松吉祐児, 城戸潤力, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • ニワトリ胚における砂嚢平滑筋層分化の経時的変化

    穐本翔太, 徳永亘祐, 鈴木貴弘, 辰巳隆一, 中村真子

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

    Language:Others  

    Country:Other  

  • Sema3A依存的な遅筋型筋線維形成機構の食品機能学的制御:クロロゲン酸のSema3A受容体アゴニスト活性の検証

    坂田拡太, 松吉祐児, 水野谷航, 鈴木貴弘, 中村真子, 辰巳隆一

    日本畜産学会 第128回大会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 培養基質の弾性率が筋幹細胞による自律的な筋線維型制御に与える影響

    鈴木貴弘

    第8回骨格筋生物学研究会【オンライン開催】  2021.3 

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    Event date: 2021.3

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    Country:Other  

  • 神経筋接合部の形態観察を目的とした上腕二頭筋損傷モデルの検討

    松吉祐児, 鈴木貴弘, 中村真子, 辰巳隆一

    第6回 日本筋学会学術集会【Web開催】  2020.12 

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    Event date: 2020.12

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    Country:Other  

  • 筋幹細胞の機能的不均一性について-筋線維型の制御に着目したアプローチ-

    鈴木貴弘

    第21回日本畜産学会若手企画シンポジウム【オンライン開催】  2020.11 

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    Event date: 2020.11

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    Country:Other  

  • myogeninが筋幹細胞の分化に与える影響を骨格筋種で比較する (The comparative study for physiological function of myogenin in myogenic stem cells isolated from different muscles.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    鈴木貴弘, 有松里央, 尾嶋孝一, 小林謙, 西邑隆徳

    日本畜産学会 第127回大会  2020.3 

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    Event date: 2020.3

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    Venue:京都大学 京都府   Country:Other  

  • 筋幹細胞が合成するNetrin-4の筋線維型制御への関与 (Netrin-4 synthesized in myogenic stem cells may regulate myofiber-types.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    前野岳大, 有松里央, 久枝皓雅, 山谷有希, 小林謙, 西邑隆徳, 鈴木貴弘

    日本畜産学会 第127回大会  2020.3 

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    Event date: 2020.3

    Language:Others  

    Venue:京都大学 京都府   Country:Other  

  • 筋原線維内の太いフィラメントにおけるミオシン分子置換に及ぼすユビキチンリガーゼの影響 (Overexpressed-ubiquitin ligase reduces myosin replacement rate in thick filament of myofibrils.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    市村恵美, 尾嶋孝一, 鈴木貴弘, 小林謙, 西邑隆徳

    日本畜産学会 第127回大会  2020.3 

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    Event date: 2020.3

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    Venue:京都大学 京都府   Country:Other  

  • 乳房炎発症の際に大腸菌および黄色ブドウ球菌由来の毒素が引き起こす初期応答の違いを細胞生理学的に明らかにする研究 (Lipopolysaccharide and lipoteichoic acid differently influence lactating bovine mammary epithelial cells.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    津上優作, 小林謙, 鈴木徳宏, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第127回大会  2020.3 

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    Event date: 2020.3

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    Venue:京都大学 京都府   Country:Other  

  • クルクミンは乳腺上皮細胞の乳産生を複合的に抑制する (Multiple adverse effects of curcumin on milk production in lactating mammary epithelial cells.) *新型コロナウィルス感染拡大の影響により中止 (要旨受理済み)

    小林謙, 津上優作, 鈴木徳宏, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第127回大会  2020.3 

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    Event date: 2020.3

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    Venue:京都大学 京都府   Country:Other  

  • Netrin-1 synthesized in satellite cells isolated from fast-twitch muscle may promote fast myofiber-type commitment. International conference

    Suzuki, T, Mori, A, Ichimura, E, Nishi, Y, Arimatsu, R, Maeno, T, Kobayashi, K, Ojima, K, Tatsumi, R, Nishimura, T

    The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) 2019 meeting  2019.12 

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    Event date: 2019.12

    Language:English  

    Venue:Washington, DC   Country:United States  

    Netrin-1 synthesized in satellite cells isolated from fast-twitch muscle may promote fast myofiber-type commitment.

  • The replacement of myosin molecules in thick filaments is different between slow- and fast-twitch myofibers. International conference

    Kigaki, M, Ojima, K, Suzuki, T, Kobayashi, K, Nishimura, T

    The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) 2019 meeting  2019.12 

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    Event date: 2019.12

    Language:English  

    Venue:Washington, DC   Country:United States  

    The replacement of myosin molecules in thick filaments is different between slow- and fast-twitch myofibers.

  • 多機能性細胞外因子semaphorin 3Eが筋分化に与える影響; A Multi-potent cell regulator semaphorin 3E may affect myogenic differentiation

    久枝皓雅, 鈴木貴弘

    第7回 若手による骨格筋細胞研究会  2019.10 

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    Event date: 2019.10

    Language:Others  

    Venue:コープイン京都大学生協事業センター 京都府   Country:Other  

  • 筋幹細胞が合成するNetrin-1は筋管の速筋化を誘導する; Netrin-1 abundantly synthesized in satellite cells isolated from fast-twitch muscles may promote fast myofiber-type commitment

    鈴木貴弘

    第7回 若手による骨格筋細胞研究会  2019.10 

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    Event date: 2019.10

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    Venue:コープイン京都大学生協事業センター 京都府   Country:Other  

  • クルクミンは乳腺上皮細胞に対して影響力の大きい生理活性物質である

    小林謙, 津上優作, 隈井仰, 鈴木徳宏, 鈴木貴弘, 西邑隆徳

    第24回 日本乳房炎研究会・学術集会  2019.10 

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    Event date: 2019.10

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    Venue:東北大学 宮城県   Country:Other  

  • リポ多糖とリポタイコ酸がウシ乳腺上皮細胞の乳産生とタイトジャンクションに及ぼす影響

    津上優作, 隈井仰, 鈴木徳宏, 鈴木貴弘, 西邑隆徳, 小林謙

    第24回 日本乳房炎研究会・学術集会  2019.10 

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    Event date: 2019.10

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    Venue:東北大学 宮城県   Country:Other  

  • Myogenin has distinct function in satellite cells isolated from different muscles. International conference

    Arimatsu, R, Nishi, Y, Kobayashi, K, Tatsumi, R, Ojima, K, Nishimura, T, Suzuki, T

    Society for Muscle Biology 2019 meeting on Frontiers in Myogenesis Meeting “Skeletal Muscle: Development, Regeneration and Disease  2019.9 

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    Event date: 2019.9

    Language:English  

    Venue:San José   Country:Costa Rica  

    Myogenin has distinct function in satellite cells isolated from different muscles.

  • Netrin-1 synthesized in satellite cells may promote fast myofiber-type commitment during myogenic differentiation phase. International conference

    Suzuki, T, Mori, A, Nishi, Y, Arimatsu, R, Maeno, T, Kobayashi, K, Ojima, K, Tatsumi, R, Nishimura, T

    Society for Muscle Biology 2019 meeting on Frontiers in Myogenesis Meeting “Skeletal Muscle: Development, Regeneration and Disease  2019.9 

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    Event date: 2019.9

    Language:English  

    Venue:San José   Country:Costa Rica  

    Netrin-1 synthesized in satellite cells may promote fast myofiber-type commitment during myogenic differentiation phase.

  • マウス系統間における筋幹細胞の機能的不均一性の検証

    鈴木貴弘, 西百合子, 有松里央, 小林謙, 西邑隆徳

    日本畜産学会 第126回大会  2019.9 

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    Venue:岩手大学 岩手県   Country:Other  

  • ウシ乳腺上皮細胞を用いた培養モデルの作製とその応用

    津上優作, 鈴木徳宏, 若狹遥, 鈴木貴弘, 西邑隆徳, 小林謙

    第6回 乳房炎サマーキャンプ  2019.9 

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    Venue:佐島マリーナホテル 神奈川県   Country:Other  

  • 培養温度が乳腺上皮組織の形態形成に及ぼす影響

    若狹遥, 津上優作, 鈴木徳宏, 鈴木貴弘, 西邑隆徳, 小林謙

    第6回 乳房炎サマーキャンプ  2019.9 

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    Venue:佐島マリーナホテル 神奈川県   Country:Other  

  • ペパーミント精油は乳腺上皮細胞の乳産生能を低下させるか

    鈴木徳宏, 津上優作, 若狹遥, 鈴木貴弘, 西邑隆徳, 小林謙

    第6回 乳房炎サマーキャンプ  2019.9 

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    Event date: 2019.9

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    Venue:佐島マリーナホテル 神奈川県   Country:Other  

  • 培養基質の弾性率が筋芽細胞による自律的な筋線維型制御に与える影響

    山谷有希, 有松里央, 前野岳大, 久江未記, 小林謙, 辰巳隆一, 尾嶋孝一, 西邑隆徳, 鈴木貴弘

    第5回 日本筋学会学術集会  2019.8 

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    Event date: 2019.8

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    Venue:東京大学 東京都   Country:Other  

  • 筋幹細胞が合成するNetrin-1は速筋型筋線維の形成誘導に関与する

    鈴木貴弘, 森愛華, 久枝皓雅, 西百合子, 小林謙, 辰巳隆一, 尾嶋孝一, 西邑隆徳

    第5回 日本筋学会学術集会  2019.8 

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    Event date: 2019.8

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    Venue:東京大学 東京都   Country:Other  

  • ウシ乳腺上皮細胞を用いたin vitro乳分泌モデルの作製とその有用性の検討

    津上優作, 鈴木徳宏, 隈井仰, 鈴木貴弘, 西邑隆徳, 小林謙

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

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    Venue:麻布大学 神奈川県   Country:Other  

  • 脂肪細胞が筋細胞の筋線維型決定に及ぼす影響

    趙暁琳, 徐康珉, 鈴木貴弘, 小林謙, 西邑隆徳

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

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    Venue:麻布大学 神奈川県   Country:Other  

  • 筋幹細胞の合成・分泌因子Netrin-1 による速筋型筋線維の形成誘導

    鈴木貴弘, 森愛華, 久枝皓雅, 西百合子, 有松里央, 小林謙, 辰巳隆一, 尾嶋孝一, 西邑隆徳

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

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    Venue:麻布大学 神奈川県   Country:Other  

  • 筋原線維内のミオシン分子置換様相は筋線維型によって異なる

    城垣誠大, 尾嶋孝一, 鈴木貴弘, 小林謙, 西邑隆徳

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

    Language:Others  

    Venue:麻布大学 神奈川県   Country:Other  

  • 生体内組織形成術を用いて作製したウシ由来バイオシートの性状に及ぼす生体内環境の影響

    今山知佳, 寺澤武, 中山泰秀, 三谷朋弘, 市居修, 池田哲平, 小千田圭吾, 小林謙, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

    Language:Others  

    Venue:麻布大学 神奈川県   Country:Other  

  • 乳腺上皮細胞に発現する甘味受容体の生理作用に関する研究

    小林謙, 津上優作, 鈴木徳宏, 隈井仰, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

    Language:Others  

    Venue:麻布大学 神奈川県   Country:Other  

  • ペパーミントが乳腺上皮細胞の乳産生能を低下させる機序に関する研究

    鈴木徳宏, 隈井仰, 津上優作, 鈴木貴弘, 西邑隆徳, 小林謙

    日本畜産学会 第125回大会  2019.3 

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    Event date: 2019.3

    Language:Others  

    Venue:麻布大学 神奈川県   Country:Other  

  • 衛星細胞が発現するsemaphorinおよびNetrinファミリーは筋線維型の制御に関わるかもしれない

    鈴木 貴弘

    第6回 若手による骨格筋細胞研究会  2018.11 

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    Event date: 2018.11

    Language:Others  

    Venue:大阪大学 大阪府   Country:Other  

  • イソフラボンが泌乳期乳腺上皮細胞へ及ぼす影響の体系的解明

    津上優作, 隈井仰, 鈴木徳宏, 鈴木貴弘, 西邑隆徳, 小林謙

    第23回 日本乳房炎研究会・学術集会  2018.10 

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    Event date: 2018.10

    Language:Others  

    Venue:機械振興会館 東京都   Country:Other  

  • 高濃度イソフラボンが妊娠期乳腺の形態形成に及ぼす影響

    隈井仰, 津上優作, 鈴木徳宏, 鈴木貴弘, 西邑隆徳, 小林謙

    第23回 日本乳房炎研究会・学術集会  2018.10 

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    Event date: 2018.10

    Language:Others  

    Venue:機械振興会館 東京都   Country:Other  

  • 筋幹細胞分泌因子による筋線維型制御 Invited

    辰巳隆一, 鈴木貴弘, MaiKhoi Q. Do, 水野谷航, 西邑隆徳

    第161回 日本獣医学会学術集会「One Health-人と動物の健康と共生」 シンポジウム:「透けてきたSkelton:骨格・筋・結合組織の形態形成機構」  2018.9 

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    Event date: 2018.9

    Language:Others  

    Venue:つくば国際会議場 茨城県   Country:Other  

  • マウス系統種の違いによる衛星細胞の分化能の比較

    西百合子, 有松里央, 森愛華, 福地達貴, 久枝皓雅, 小林謙, 辰巳隆一, 西邑隆徳, 鈴木貴弘

    第4回 日本筋学会学術集会  2018.8 

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    Event date: 2018.8

    Language:Others  

    Venue:川崎医科大学 岡山県   Country:Other  

  • 遅筋と速筋それぞれに局在する衛星細胞は独自の筋線維型制御機構を有する

    鈴木貴弘, 辰巳隆一, 森愛華, 久枝皓雅, 西百合子, 小林謙, 尾嶋孝一, 西邑隆徳

    第4回 日本筋学会学術集会 「シンポジウム2-骨格筋の可塑性と再生能を支える筋衛星細胞とエピジェネティック制御-」  2018.8 

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    Event date: 2018.8

    Language:Others  

    Venue:川崎医科大学 岡山県   Country:Other  

  • 衛星細胞におけるmyogeninの機能は局在部位で異なる

    有松里央, 西百合子, 小林謙, 西邑隆徳, 鈴木貴弘

    第4回 日本筋学会学術集会  2018.8 

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    Event date: 2018.8

    Language:Others  

    Venue:川崎医科大学 岡山県   Country:Other  

  • Expression profiles of semaphorin and Netrin family subtypes in satellite cells during myogenic differentiation phase: toward further understanding of myofiber-type commitment models. International conference

    Suzuki, T, Mori, A, Hisaeda, K, Nishi, Y, Kobayashi, K, Matsuyoshi, Y, Tatsumi, R, Ojima, K, Nishimura, T

    2018 FASEB Science Research Conference on Skeletal Muscle Satellite Cells and Regeneration  2018.7 

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    Event date: 2018.7

    Language:English  

    Venue:Steamboat Springs, CO   Country:United States  

    Expression profiles of semaphorin and Netrin family subtypes in satellite cells during myogenic differentiation phase: toward further understanding of myofiber-type commitment models.

  • イヌ肺動脈に異種移植したウシ由来バイオシートの組織構造(優秀発表賞受賞)

    今山知佳, 鈴木貴弘, 小林謙, 三谷朋弘, 市居修, 中山泰秀, 古越真耶, 池田哲平, 小千田圭吾, 西邑隆徳

    日本畜産学会 第124回大会  2018.3 

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    Event date: 2018.3

    Language:Others  

    Venue:東京大学 東京都   Country:Other  

  • 衛星細胞由来のSema3Aによる遅筋線維の形成誘導メカニズムの解析

    橋本尚弥, 西百合子, 森愛華, 小林謙, 辰巳隆一, 西邑隆徳, 鈴木貴弘

    日本畜産学会 第124回大会  2018.3 

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    Event date: 2018.3

    Language:Others  

    Venue:東京大学 東京都   Country:Other  

  • 骨格筋筋原線維内ミオシン分子の置換はHsp90により促進される

    尾嶋孝一, 市村恵美, 大江美香, 室谷進, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第123回大会  2017.9 

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    Event date: 2017.9

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    Venue:信州大学 長野県   Country:Other  

  • 筋幹細胞由来分泌因子による筋線維型制御機構に関する研究-速筋化誘導因子の候補netrinに着目して-

    鈴木貴弘, 森愛華, 西百合子, 橋本尚弥, 小林謙, 辰巳隆一, 西邑隆徳

    第3回 日本筋学会学術集会  2017.8 

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    Event date: 2017.8

    Language:Others  

    Venue:国立精神・神経医療研究センター 東京都   Country:Other  

  • イソフラボンが乳腺上皮細胞における乳産生へ及ぼす影響

    津上優作, 松長康太, 鈴木貴弘, 西邑隆徳, 小林謙

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 筋幹細胞分泌因子netrinの筋線維型制御作用を検証する

    鈴木貴弘, 西百合子, 橋本尚弥, 小林謙, 辰巳隆一, 西邑隆徳

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

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    Venue:神戸大学 兵庫県   Country:Other  

  • 筋原線維に組み込まれていないミオシン分子の量が太いフィラメントのミオシン分子置換に及ぼす影響

    尾嶋孝一, 市村恵美, 安川裕也, 室谷進, 鈴木貴弘, 西邑隆徳

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 炎症性サイトカインが乳腺上皮細胞の乳成分産生に及ぼす影響

    松長康太, 津上優作, 鈴木貴弘, 西邑隆徳, 小林謙

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 温度変化が乳腺上皮細胞の乳成分産生能力に及ぼす影響

    小林謙, 津上優作, 松長康太, 鈴木貴弘, 西邑隆徳

    日本畜産学会大会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 成熟脂肪細胞が筋芽細胞の分化に及ぼす影響

    Seo Kangmin, 鈴木貴弘, 小林謙, 西邑隆徳

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 家畜生体内を利用して再生医療用組織をつくる

    西邑隆徳, 今山知佳, 鈴木貴弘, 小林謙, 三谷朋弘, 市居修, 小千田圭吾, 池田哲平, 寺澤武, 中山泰秀

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • マウス系統種の違いによる筋幹細胞の筋分化能力を比較する

    西百合子, 小林謙, 西邑隆徳, 鈴木貴弘

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • ウシ生体内で形成させた再生医療移植用組織の構造

    今山知佳, 鈴木貴弘, 小林謙, 三谷朋弘, 市居修, 小千田圭吾, 池田哲平, 寺澤武, 中山泰秀

    日本畜産学会 第122回大会  2017.3 

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    Event date: 2017.3

    Language:Others  

    Venue:神戸大学 兵庫県   Country:Other  

  • 各骨格筋由来のサテライト細胞の特徴を検証する

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 濃野勉, 橋本尚弥, 西百合子, 小林謙, 辰巳隆一, 西邑隆徳

    第四回 若手による骨格筋細胞研究会  2016.11 

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    Event date: 2016.11

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    Venue:ウインクあいち 愛知県   Country:Other  

  • 骨格筋幹細胞の新たな役割を探る -筋線維型自律制御機構に着目して-

    鈴木貴弘

    日本畜産学会 若手企画 サマーキャンプ 「アニマルサイエンス若手研究者の胎動」  2016.9 

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    Event date: 2016.9

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    Venue:基礎生物学研究所 愛知県   Country:Other  

  • Satellite cells isolated from soleus muscle may autonomously form slow-twitch fibers via Sema3A signaling. International conference

    Suzuki, T, Mori, A, Hisaeda, K, Nishi, Y, Kobayashi, K, Matsuyoshi, Y, Tatsumi, R, Ojima, K, Nishimura, T

    Animal Science Congress 2016 of the Asian-Australian Association of Animal Production Societies (17th AAAP)  2016.8 

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    Event date: 2016.8

    Language:English  

    Venue:Kyushu Sangyo University, Fukuoka   Country:Japan  

    Satellite cells isolated from soleus muscle may autonomously form slow-twitch fibers via Sema3A signaling.

  • 各骨格筋に局在するサテライト細胞の部域特異性を検証する

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 濃野勉, 小林謙, 水野谷航, 大澤裕, 砂田芳秀, 辰巳隆一, 西邑隆徳

    各骨格筋に局在するサテライト細胞の部域特異性を検証する  2016.8 

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    Event date: 2016.8

    Language:Others  

    Venue:日本筋学会学術集会 国立精神・神経医療研究センター 東京都   Country:Other  

  • 骨格筋形成における脱アミノ化酵素APOBEC2の機能

    大坪秀明, 佐藤祐介, 鈴木貴弘, 水野谷航, 中村真子, 辰巳隆一, 池内義秀

    日本畜産学会 第121回大会  2016.3 

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    Event date: 2016.3

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    Venue:日本獣医生命科学大学 東京都   Country:Other  

  • 馬肉摂取による体温低下作用に関する研究

    黒田裕介, 鈴木貴弘, 西邑隆徳, 若松純一

    日本畜産学会 第121回大会  2016.3 

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    Event date: 2016.3

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    Venue:日本獣医生命科学大学 東京都   Country:Other  

  • 長期塩漬ハムの風味に寄与する微生物の探索

    森綾音, 鈴木貴弘, 西邑隆徳, 生田稔, 日置昭二, 若松純一

    日本畜産学会 第121回大会  2016.3 

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    Event date: 2016.3

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    Venue:日本獣医生命科学大学 東京都   Country:Other  

  • 亜鉛プロトポルフィリンIX形成能が高い微生物の探索

    大屋桃, 川添穂高, 鈴木貴弘, 西邑隆徳, 若松純一

    日本畜産学会 第121回大会  2016.3 

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    Event date: 2016.3

    Language:Others  

    Venue:日本獣医生命科学大学 東京都   Country:Other  

  • The effects of DKK3 expression in oral squamous cell carcinoma cells

    片瀬直樹, 寺田久美子, 西松伸一郎, 鈴木貴弘, 松崎秀紀, 山村真弘, 山内明, 大槻剛巳, 濃野勉

    BMB2015 (第38回日本分子生物学会年会, 第88回日本生化学会大会 合同大会)  2015.12 

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    Event date: 2015.12

    Language:Others  

    Venue:神戸ポートランド 兵庫県   Country:Other  

  • 骨格筋サテライト細胞の部域特異性の検討

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 大澤裕, 砂田芳秀, 辰巳隆一, 濃野勉

    BMB2015 (第38回日本分子生物学会年会, 第88回日本生化学会大会 合同大会)  2015.12 

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    Event date: 2015.12

    Language:Others  

    Venue:神戸ポートランド 兵庫県   Country:Other  

  • 骨格筋幹細胞による筋線維型制御作用についての検討

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 辰巳隆一, 濃野勉

    第三回 若手による骨格筋細胞研究会  2015.11 

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    Event date: 2015.11

    Language:Others  

    Venue:九州大学 福岡県   Country:Other  

  • Sema3Aによる筋線維型の初期決定に関する研究

    大屋雄暉, 鈴木貴弘, MaiKhoi Q. Do, 水野谷航, 中村真子, 池内義秀, 辰巳隆一

    日本畜産学会 第120回大会  2015.9 

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    Event date: 2015.9

    Language:Others  

    Venue:酪農学園大学 北海道   Country:Other  

  • 異なる骨格筋部位に局在する筋幹細胞の性質を比較する

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 辰巳隆一, 濃野勉

    日本畜産学会 第120回大会  2015.9 

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    Event date: 2015.9

    Language:Others  

    Venue:酪農学園大学 北海道   Country:Other  

  • プロセシング酵素PCSK5 による体節形成の制御

    西松伸一郎, 鈴木貴弘, 片瀬直樹, 寺田久美子, 大澤裕, 砂田芳秀, 濃野勉

    第1回 日本筋学会学術集会  2015.8 

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    Event date: 2015.8

    Language:Others  

    Venue:国立精神・神経医療研究センター 東京都   Country:Other  

  • 筋幹細胞由来のSema3Aによる筋線維型制御に関する研究

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 濃野勉, 水野谷航, 池内義秀, 辰巳隆一

    第1回 日本筋学会学術集会  2015.8 

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    Event date: 2015.8

    Language:Others  

    Venue:国立精神・神経医療研究センター 東京都   Country:Other  

  • 筋幹細胞特異的Sema3A cKOマウスの解析

    鈴木貴弘, 西松伸一郎, 寺田久美子, 片瀬直樹, 濃野勉, 水野谷航, 池内義秀, 辰巳隆一

    日本畜産学会 第119回大会  2015.3 

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    Event date: 2015.3

    Language:Others  

    Venue:宇都宮大学 栃木県   Country:Other  

  • プロセシング酵素Furinによる骨格筋形成の制御

    西松伸一郎, 大澤裕, 寺田久美子, 片瀬直樹, 鈴木貴弘, 砂田芳秀, 濃野勉

    第37回 日本分子生物学会年会  2014.11 

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    Event date: 2014.11

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    Venue:パシフィコ横浜 神奈川県   Country:Other  

    Regulation of skeletal muscle growth by the pro-protein convertase, furin.

  • 筋幹細胞由来の分泌性因子Sema3Aによる筋線維型自律制御機構

    鈴木貴弘, 大屋雄暉, 澤野祥子, 大坪秀明, 水野谷航, 中村真子, 池内義秀, 辰巳隆一

    第37回 日本分子生物学会年会  2014.11 

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    Event date: 2014.11

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    Venue:パシフィコ横浜 神奈川県   Country:Other  

    Sema3A secreted from satellite cells promotes slow-twitch fiber generation.

  • Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression. International conference

    Sakaguchi, S, Shono, J, Suzuki, T, Sawano, S, Anderson, JE, Do, M-KQ, Ohtsubo, H, Mizunoya, W, Nakamura, M, Furuse, M, Ikeuchi, Y, Tatsumi, R

    Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (16th AAAP)  2014.11 

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    Event date: 2014.11

    Language:English  

    Venue:Universitas Gadjah Mada (UGM), Yogyakarta   Country:Indonesia  

    Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.

  • Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts. International conference

    Mulan, Nakamura, M, Suzuki, T, Mizunoya, W, Ojima, K, Tatsumi, R, Ikeuchi, Y

    International Symposium on Agriculture, Forestry, Environment and Life Sciences in Asia, 2014 (AFELiSA'14)  2014.10 

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    Event date: 2014.10

    Language:English  

    Venue:Chuncheon, Gangwon   Country:Korea, Republic of  

    Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts.

  • APOBEC2 deficiency up-regulates myoblast differentiation. International conference

    Ohtsubo, H, Sato, Y, Suzuki, T, Mizunoya, W, Nakamura, M, Tatsumi, R, Ikeuchi, Y

    2014 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2014.7 

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    Event date: 2014.7

    Language:English  

    Venue:Steamboat Springs, CO   Country:United States  

    APOBEC2 deficiency up-regulates myoblast differentiation.

  • Sema3A secreted from satellite cells promotes slow-twitch fiber generation. International conference

    Suzuki, T, Ohya, Y, Ojima, K, Mizunoya, W, Sawano, S, Ohtsubo, H, Nishimatsu, S-I, Anderson, JE, Do, M-KQ, Nakamura, M, Furuse, M, Ikeuchi, Y, Nohno, T, Tatsumi, R

    2014 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2014.7 

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    Event date: 2014.7

    Language:English  

    Venue:Steamboat Springs, CO   Country:United States  

    Sema3A secreted from satellite cells promotes slow-twitch fiber generation.

  • M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression. International conference

    Tatsumi, R, Sakaguchi, S, Shono, J, Suzuki, T, Sawano, S, Anderson, JE, Do, M-KQ, Ohtsubo, H, Mizunoya, W, Nakamura, M, Furuse, M, Ikeuchi, Y

    2014 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2014.7 

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    Event date: 2014.7

    Language:English  

    Venue:Steamboat Springs, CO   Country:United States  

    M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.

  • 筋幹細胞による筋線維型自律制御機構は食品成分によって制御できる

    鈴木貴弘, 水野谷航, 赤星眞理子, 尾嶋孝一, 大坪秀明, 中村真子, 池内義秀, 和賀俊明, 辰巳隆一

    日本畜産学会 第118回大会  2014.3 

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    Event date: 2014.3

    Language:Others  

    Venue:つくば国際会議場 茨城県   Country:Other  

  • 脱アミノ化酵素APOBEC2の欠損が筋再生に及ぼす影響

    大坪秀明, 佐藤祐介, 鈴木貴弘, 水野谷航, 中村真子, 辰巳隆一, 池内義秀

    日本畜産学会 第118回大会  2014.3 

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    Event date: 2014.3

    Language:Others  

    Venue:つくば国際会議場 茨城県   Country:Other  

  • Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation. International conference

    Suzuki, T, Ojima, K, Do, M-KQ, Hara, M, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, JE, Tatsumi, R

    2013 EMBO Workshop on “Semaphorin Function and Mechanism in Action.  2013.10 

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    Event date: 2013.10

    Language:English  

    Venue:Cemay-la-Ville   Country:France  

    Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation.

  • 脱アミノ化酵素APOBEC2の欠損が筋細胞の分化に及ぼす影響

    大坪秀明, 佐藤祐介, 鈴木貴弘, 水野谷航, 中村真子, 辰巳隆一, 池内義秀

    日本畜産学会 第117回大会  2013.9 

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    Event date: 2013.9

    Language:Others  

    Venue:新潟大学 新潟県   Country:Other  

  • 筋幹細胞由来の分泌因子Sema3Aによる筋線維型自律制御機構の解明

    鈴木貴弘, 尾嶋孝一, 大屋雄暉, 大坪秀明, 水野谷航, 中村真子, 池内義秀, 辰巳隆一

    日本畜産学会 第117回大会  2013.9 

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    Event date: 2013.9

    Language:Others  

    Venue:新潟大学 新潟県   Country:Other  

  • 筋幹細胞による筋線維型の自律制御機構

    鈴木貴弘, 尾嶋孝一, 水野谷航, 中村真子, 池内義秀, 辰巳隆一

    日本畜産学会 第116回大会  2013.3 

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    Event date: 2013.3

    Language:Others  

    Venue:安田女子大学 広島県   Country:Other  

  • 筋肉細胞分化時における筋幹細胞マーカーPax7とセマフォリン3A の機能解明

    中村真子, 中條裕子, 鈴木貴弘, 西岡沙織, 上野惟, 水野谷航, 辰巳隆一, 池内義秀

    日本畜産学会 第116回大会  2013.3 

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    Event date: 2013.3

    Language:Others  

    Venue:安田女子大学 広島県   Country:Other  

  • Regulation mechanism of muscle cells differentiation by a paired box protein, pax7 and Semaphorin 3A.(ペアードボックス転写因子Pax7とセマフォリン3Aによる筋肉細胞分化制御機構の解明)

    中村真子, 中條裕子, 鈴木貴弘, 西岡沙織, 上野惟, 水野谷航, 辰巳隆一, 池内義秀

    第35回 日本分子生物学会年会 (15-c) 発生-細胞・組織分化  2012.12 

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    Event date: 2012.12

    Language:Others  

    Venue:マリンメッセ福岡 福岡県   Country:Other  

  • Heparan/chondroitin sulfate chains may mediate HGF/FGF2-induced up-regulation of neural chemorepellent Sema3A in satellite cell cultures. International conference

    Do, M-KQ, Shimizu, N, Suzuki, T, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, JE, Tatsumi, R

    2012 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2012.8 

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    Event date: 2012.8

    Language:English  

    Venue:Lucca   Country:Italy  

    Heparan/chondroitin sulfate chains may mediate HGF/FGF2-induced up-regulation of neural chemorepellent Sema3A in satellite cell cultures.

  • Semaphorin 3A regulates the early differentiation of satellite cells. International conference

    Suzuki, T, Ojima, K, Do, M-KQ, Hara, M, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, JE, Tatsumi, R

    2012 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2012.8 

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    Event date: 2012.8

    Language:English  

    Venue:Lucca   Country:Italy  

    Semaphorin 3A regulates the early differentiation of satellite cells.

  • Mechano-Sensing Calcium-Influx Machinery that Instigates Skeletal Muscle Satellite Cell Activation. International conference

    Tatsumi, R, Hara, M, Tabata, K, Suzuki, T, Do, M.-KQ, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, JE, Allen, RE

    2012 FASEB Science Research Conference on Skeletal Muscle Satellite & Stem Cells.  2012.8 

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    Event date: 2012.8

    Language:English  

    Venue:Lucca   Country:Italy  

    Mechano-Sensing Calcium-Influx Machinery that Instigates Skeletal Muscle Satellite Cell Activation.

  • Studies on receptors responsible for growth factor-regulated Sema3A expression in satellite cells.

    MaiKhoi Q. Do, 清水直美, 鈴木貴弘, 水野谷航, 中村真子, 辰巳隆一, 池内義秀

    日本畜産学会 第115回大会  2012.3 

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    Event date: 2012.3

    Language:Others  

    Venue:名古屋大学 愛知県   Country:Other  

  • semaphorin 3A は筋幹細胞の初期分化を制御する

    鈴木貴弘, 尾嶋孝一, 佐藤祐介, 中村真子, 水野谷 航, 辰巳 隆一, 池内 義秀

    日本畜産学会 第115回大会  2012.3 

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    Event date: 2012.3

    Language:Others  

    Venue:名古屋大学 愛知県   Country:Other  

  • 筋幹細胞が分泌するsemaphorin 3Aの生理機能

    鈴木貴弘, 尾嶋孝一, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 池内 義秀

    日本畜産学会 第114回大会  2011.8 

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    Event date: 2011.8

    Language:Others  

    Venue:北里大学 青森県   Country:Other  

  • 筋細胞におけるsemaphorin 3Aの機能 *東日本大震災の影響により中止 (要旨受理済み)

    鈴木貴弘, 佐藤祐介, 原美菜子, 水野谷航, 辰巳隆一, 池内義秀

    日本畜産学会 第113回大会  2011.3 

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    Event date: 2011.3

    Language:Others  

    Venue:東京農業大学 神奈川県 *東日本大震災の影響により中止 (要旨受理済み)   Country:Other  

  • Possible implication of satellite cells in regenerative motoneuritogenesis : HGF and FGF2 up-regulates neural chemorepellent Sema3A expression. International conference

    Tatsumi, R, Do, M-KQ, Shimizu, N, Anderson, JE, Sato, Y, Suzuki, T, Mizunoya, W, Ikeuchi, Y, Allen, RE

    the 6th World Congress on Biomedical in conjunction with the 14th International Conference on Engineering (ICBME) 2010 and the 5th Asian Pacific Conference on Biomechanics (APBiomech) 2010  2010.8 

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    Event date: 2010.8

    Language:English  

    Venue:Suntec Singapore Convention and Exhibition Center, Singapore   Country:Singapore  

    Possible implication of satellite cells in regenerative motoneuritogenesis : HGF and FGF2 up-regulates neural chemorepellent Sema3A expression.

  • Possible implication of satellite cells in regenerative motoneuritogenesis : Temporal coordination of HGF/FGF2/TGF-beta may regulate neural chemorepellent Sema3A. International conference

    Do, M-KQ, Shimizu, N, Suzuki, T, Tatsumi, R, Mizunoya, W, Ikeuchi, Y, Anderson, JE, Allen, RE

    2010 FASEB Summer Research Conference on Skeletal Muscle Satellite & Stem Cells.  2010.7 

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    Event date: 2010.7

    Language:English  

    Venue:Carefree, AZ, U.S.A.   Country:United States  

    Possible implication of satellite cells in regenerative motoneuritogenesis : Temporal coordination of HGF/FGF2/TGF-beta may regulate neural chemorepellent Sema3A.

  • semaphorin 3A による筋衛星細胞の分化促進

    鈴木貴弘, 清水直美, 山田路子, 辰巳隆一, 水野谷航, 池内義秀

    日本畜産学会 第112回大会  2010.3 

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    Event date: 2010.3

    Language:Others  

    Venue:明治大学 東京都   Country:Other  

  • 筋幹細胞における運動神経軸索ガイダンス因子Sema3Aの発現調節

    清水直美, 鈴木貴弘, 山田路子, 佐藤祐介, 水野谷航, 辰巳隆一, 池内 義秀

    日本畜産学会 第111回大会  2009.9 

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    Event date: 2009.9

    Language:Others  

    Venue:琉球大学 沖縄   Country:Other  

  • semaphorin 3A が筋衛星細胞の分化に及ぼす影響

    鈴木貴弘, 清水直美, 山田路子, 辰巳隆一, 水野谷航, 池内義秀

    日本畜産学会 第111回大会  2009.9 

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    Event date: 2009.9

    Language:Others  

    Venue:琉球大学 沖縄   Country:Other  

  • A possible role for satellite cells in regenerative motoneurogenesis: HGF up-regulates neural chemorepellent Sema3A expression. International conference

    Tatsumi, R, Sankoda, Y, Anderson, JE, Sato, Y, Mizunoya, W, Shimizu, N, Suzuki, T, Yamada, M, Robert, PR. Jr, Ikeuchi, Y, Allen, RE

    Making Muscle and the Embryo and Adult, A Joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells  2009.5 

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    Event date: 2009.5 - 2009.6

    Language:English  

    Venue:Alfred Lerner Hall at Columbia University, NY, U.S.A.   Country:United States  

    A possible role for satellite cells in regenerative motoneurogenesis: HGF up-regulates neural chemorepellent Sema3A expression.

  • 骨格筋の部位に準じた衛星細胞の特性を分化誘導過程において比較する

    鈴木 貴弘, 村本 匠, 前野 岳大, 川崎 佑華, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋芽細胞による自律的な筋線維型制御における機械的伸展刺激の影響

    中田 后紀, 川崎 佑華, 大山 竜輝, 前野 岳大, 今給黎 燿, 小川 陽平, 大崎 莉果, 小川 蒼生, 保坂 善真, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋肉の脱ニトロ化活性 老齢マウスではなく若齢マウスにおける再生アップレギュレーション(Muscle De-nitration Activity: Regenerative Upregulation in Young, not Old Mice)

    Elgaabari Alaa, Tanaka Sakiho, Zushi Kahona, Kuwakado So, Seki Miyumi, Suzuki Takahiro, Nakamura Mako, Tatsumi Ryuichi

    日本筋学会学術集会・筋ジストロフィー医療研究会合同学術集会プログラム・抄録集  2023.8  日本筋学会・筋ジストロフィー医療研究会

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  • 筋幹細胞活性化因子HGFのニトロ化による不活化に関する研究 抗HGFモノクローナル抗体のニトロ化抑制効果の検証

    田中 咲帆, Alaa Elgaabari, 圖師 歌歩乃, 澤野 祥子, 水野谷 航, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋幹細胞活性化因子HGFのニトロ化による不活化に関する研究:ニトロ化を抑制する化合物

    関 美弓, Elgaabari Alaa, 田中 咲帆, 澤野 祥子, 水野谷 航, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋幹細胞分泌因子semaphorin3Aによる筋線維型制御機構 速筋型筋線維の形成抑制機能について

    金子 琉輝, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋幹細胞で発現するnetrin受容体の筋分化への関与

    前野 岳大, 小川 陽平, 尾嶋 孝一, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋幹細胞が合成するsemaphorinおよびnetrinサブファミリーの生理機能に関する研究

    鈴木 貴弘, 前野 岳大, 今給黎 耀, 川崎 佑華, 中田 后紀, 小川 陽平, 中村 真子, 辰巳 隆一

    日本筋学会学術集会・筋ジストロフィー医療研究会合同学術集会プログラム・抄録集  2023.8  日本筋学会・筋ジストロフィー医療研究会

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  • 物理刺激培養モデルを用いた筋管の筋線維型制御機構の変化

    鈴木 貴弘, 川崎 佑華, 中田 后紀, 大山 竜輝, 江草 愛, 保坂 善真, 前野 岳大, 今給黎 燿, 小川 陽平, 大崎 莉果, 小川 蒼生, 中村 真子, 辰巳 隆一

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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  • 弾性刺激と電気刺激が筋芽細胞による自律的な筋線維型制御に及ぼす影響

    川崎 佑華, 江草 愛, 室田 大輝, 大山 竜輝, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 廃用による筋幹細胞の活性化阻害に関する報告

    桑門 想, Alaa Elgaabari, 鈴木 貴弘, 川口 謙一, 中島 康晴, 辰巳 隆一

    The Japanese Journal of Rehabilitation Medicine  2023.10  (公社)日本リハビリテーション医学会

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  • 分化型および脱分化型平滑筋細胞におけるギャップ結合因子コネキシン43の発現解析

    中込睦生, 徳永亘祐, 穐本翔太, 饗場万知子, 鈴木貴弘, 辰巳隆一, 中村真子

    日本農芸化学会2022年度(令和4年度)京都大会  2022.3 

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  • オレイン酸摂取はマウス骨格筋において1型および2X型筋線維を増加させる

    小宮 佑介, 伊関 柊吾, 鈴木 貴弘, 辰巳 隆一, 澤野 祥子, 水野谷 航, 長竿 淳, 有原 圭三

    日本栄養・食糧学会大会講演要旨集  2023.3  (公社)日本栄養・食糧学会

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  • 骨格筋をターゲットとしたオレイン酸の新規機能性

    小宮 佑介, 伊関 柊吾, 渡邉 奈穂美, 佐藤 祐介, 鈴木 貴弘, 辰巳 隆一, 澤野 祥子, 水野谷 航, 横山 壱成, 長竿 淳, 有原 圭三

    東北畜産学会報  2024.8  東北畜産学会

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  • 骨格筋の部位に準じた衛星細胞の特性を分化誘導過程において比較する

    鈴木 貴弘, 村本 匠, 前野 岳大, 川崎 佑華, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋芽細胞による自律的な筋線維型制御における機械的伸展刺激の影響

    中田 后紀, 川崎 佑華, 大山 竜輝, 前野 岳大, 今給黎 燿, 小川 陽平, 大崎 莉果, 小川 蒼生, 保坂 善真, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋肉の脱ニトロ化活性 老齢マウスではなく若齢マウスにおける再生アップレギュレーション(Muscle De-nitration Activity: Regenerative Upregulation in Young, not Old Mice)

    Elgaabari Alaa, Tanaka Sakiho, Zushi Kahona, Kuwakado So, Seki Miyumi, Suzuki Takahiro, Nakamura Mako, Tatsumi Ryuichi

    日本筋学会学術集会・筋ジストロフィー医療研究会合同学術集会プログラム・抄録集  2023.8  日本筋学会・筋ジストロフィー医療研究会

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  • 筋幹細胞活性化因子HGFのニトロ化による不活化に関する研究 抗HGFモノクローナル抗体のニトロ化抑制効果の検証

    田中 咲帆, Alaa Elgaabari, 圖師 歌歩乃, 澤野 祥子, 水野谷 航, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋幹細胞活性化因子HGFのニトロ化による不活化に関する研究:ニトロ化を抑制する化合物

    関 美弓, Elgaabari Alaa, 田中 咲帆, 澤野 祥子, 水野谷 航, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋幹細胞分泌因子semaphorin3Aによる筋線維型制御機構 速筋型筋線維の形成抑制機能について

    金子 琉輝, 松吉 祐児, 鈴木 貴弘, 中村 真子, 辰巳 隆一

    日本畜産学会大会講演要旨集  2022.9  (公社)日本畜産学会

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  • 筋幹細胞で発現するnetrin受容体の筋分化への関与

    前野 岳大, 小川 陽平, 尾嶋 孝一, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 筋幹細胞が合成するsemaphorinおよびnetrinサブファミリーの生理機能に関する研究

    鈴木 貴弘, 前野 岳大, 今給黎 耀, 川崎 佑華, 中田 后紀, 小川 陽平, 中村 真子, 辰巳 隆一

    日本筋学会学術集会・筋ジストロフィー医療研究会合同学術集会プログラム・抄録集  2023.8  日本筋学会・筋ジストロフィー医療研究会

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  • 物理刺激培養モデルを用いた筋管の筋線維型制御機構の変化

    鈴木 貴弘, 川崎 佑華, 中田 后紀, 大山 竜輝, 江草 愛, 保坂 善真, 前野 岳大, 今給黎 燿, 小川 陽平, 大崎 莉果, 小川 蒼生, 中村 真子, 辰巳 隆一

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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  • 弾性刺激と電気刺激が筋芽細胞による自律的な筋線維型制御に及ぼす影響

    川崎 佑華, 江草 愛, 室田 大輝, 大山 竜輝, 中村 真子, 辰巳 隆一, 鈴木 貴弘

    日本畜産学会大会講演要旨集  2023.9  (公社)日本畜産学会

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  • 廃用による筋幹細胞の活性化阻害に関する報告

    桑門 想, Alaa Elgaabari, 鈴木 貴弘, 川口 謙一, 中島 康晴, 辰巳 隆一

    The Japanese Journal of Rehabilitation Medicine  2023.10  (公社)日本リハビリテーション医学会

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  • オレイン酸摂取はマウス骨格筋において1型および2X型筋線維を増加させる

    小宮 佑介, 伊関 柊吾, 鈴木 貴弘, 辰巳 隆一, 澤野 祥子, 水野谷 航, 長竿 淳, 有原 圭三

    日本栄養・食糧学会大会講演要旨集  2023.3  (公社)日本栄養・食糧学会

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MISC

  • 多機能性因子の合成を介した筋衛星細胞による自律的な筋肥大誘導機構の解釈を利用した新プラットフォームの形成

    鈴木貴弘, 前野岳大, 今給黎耀, 川崎佑華, 中田后紀, 室田大輝, 中村真子, 辰巳隆一

    公益財団法人 伊藤記念財団 平成4年度「食肉に関する助成研究調査報告書 Vol.41」   2023.11

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  • The novel platform for the autonomous regulatory system of myogenic hypertrophy by multi-functional modulators synthesized in satellite cells

    鈴木貴弘, 前野岳大, 今給黎耀, 川崎佑華, 中田后紀, 室田大輝, 中村真子, 辰巳隆一

    食肉に関する助成研究調査成果報告書   41   2023

  • 筋線維型に応じて変化する筋幹細胞の特性獲得メカニズムの検証 Reviewed

    鈴木 貴弘

    公益財団法人 サッポロ生物科学振興財団 第10回(2021年度)助成研究報告書   2022.5

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  • 成熟後の効率的な筋肥大の誘導に寄与する筋幹細胞の探索(II)

    鈴木貴弘

    公益財団法人 伊藤記念財団 平成31年度(令和元年度)「食肉に関する助成研究調査報告書 Vol.38」   2020.11

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  • 骨格筋の幹細胞は働き者?怠け者? Reviewed

    鈴木貴弘

    生物工学会誌–『バイオミディア』   2020.1

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  • Netrin-1 synthesized in satellite cells isolated from fast-twitch muscle may promote fast myofiber-type commitment.

    Suzuki, T, Mori, A, Ichimura, E, Nishi, Y, Arimatsu, R, Maeno, T, Kobayashi, K, Ojima, K, Tatsumi, R, Nishimura, T

    Proceeding of The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) 2019 meeting   2019.12

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  • The replacement of myosin molecules in thick filaments is different between slow- and fast-twitch myofibers.

    Kigaki, M, Ojima, K, Suzuki, T, Kobayashi, K, Nishimura, T

    Proceeding of The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) 2019 meeting   2019.12

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  • 成熟後の効率的な筋肥大の誘導に寄与する筋幹細胞の探索 Reviewed

    鈴木貴弘

    公益財団法人 伊藤記念財団 平成30年度「食肉に関する助成研究調査報告書 Vol.37」   2019.11

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  • Myogenin has distinct function in satellite cells isolated from different muscles Reviewed

    Arimatsu, R, Nishi, Y, Kobayashi, K, Tatsumi, R, Ojima, K, Nishimura, T, Suzuki, T

    Proceeding of Society for Muscle Biology 2019 meeting on Frontiers in Myogenesis Meeting “Skeletal Muscle: Development, Regeneration and Disease   2019.9

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  • Netrin-1 synthesized in satellite cells may promote fast myofiber-type commitment during myogenic differentiation phase. Reviewed

    Suzuki, T, Mori, A, Nishi, Y, Arimatsu, R, Maeno, T, Kobayashi, K, Ojima, K, Tatsumi, R, Nishimura, T

    Proceeding of Society for Muscle Biology 2019 meeting on Frontiers in Myogenesis Meeting “Skeletal Muscle: Development, Regeneration and Disease   2019.9

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  • Expression profiles of semaphorin and Netrin family subtypes in satellite cells during myogenic differentiation phase: toward further understanding of myofiber-type commitment models. Reviewed

    Suzuki, T, Mori, A, Hisaeda, K, Nishi, Y, Kobayashi, K, Matsuyoshi, Y, Tatsumi, R, Ojima, K, Nishimura, T

    Proceeding of 2018 FASEB Science Research Conference on Skeletal Muscle Satellite Cells and Regeneration   2018.7

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  • 筋幹細胞の新たな性質を見出す

    鈴木 貴弘

    食肉の科学(日本食肉研究会)   2018.6

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  • 食肉特性の向上を目指して:ポリフェノール給餌による遅筋型筋線維の形成誘導 Reviewed

    辰巳隆一, 水野谷航, 宮原秀雄, 岡本慎平, 赤星眞理子, 鈴木貴弘, ドマイコイ, 大坪秀明, 小宮祐介, チャハラモクラン, 中村真子, 池内義秀

    公益財団法人 伊藤記念財団 平成27年度「食肉に関する助成研究調査報告書」   2016.11

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  • Satellite cells isolated from soleus muscle may autonomously form slow-twitch fibers via Sema3A signaling.

    Suzuki, T, Ohya, Y, Nishimatsu, S-I, Terada, K, Katase, N, Ohtsubo, H, Mizunoya, W, Kobayashi, K, Nohono, T, Nishimura, T, Tatsumi, R

    Proceeding of Animal Science Congress 2016 of the Asian-Australian Association of Animal Production Societies (17th AAAP)   2016.8

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  • 筋肥大・再生における異種細胞間コミュニケーションダイナミクス —筋幹細胞による運動神経支配の再構築制御(仮説)を話題にして—

    辰巳隆一, Do Mai-Khoi Quy, 鈴木貴弘, 大屋雄暉, 大坪秀明, 小宮佑介, 澤野祥子, 水野谷航, 中村真子, 池内義秀

    食肉の科学(日本食肉研究会)   2015.11

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  • 口腔扁平上皮癌におけるDKK3の発現と機能解析

    片瀬 直樹, 寺田 久美子, 鈴木 貴弘, 西松 伸一郎, 山村 真弘, 山内 明, 濃野 勉

    Journal of Oral Biosciences Supplement   2015.9

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    口腔扁平上皮癌におけるDKK3の発現と機能解析

  • Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.

    Sakaguchi, S, Shono, J, Suzuki, T, Sawano, S, Anderson, JE, Do, M-KQ, Ohtsubo, H, Mizunoya, W, Nakamura, M, Furuse, M, Ikeuchi, Y, Tatsumi, R

    Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (16th AAAP   2014.11

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  • Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts

    Mulan, Nakamura, M, Suzuki, T, Mizunoya, W, Ojima, K, Tatsumi, R, Ikeuchi, Y

    International Symposium on Agriculture, Forestry, Environment and Life Sciences in Asia, 2014 (AFELiSA'14) Kangwon National University, Chuncheon, Gangwon, Korea   2014.10

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    Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts
    Poster presentation

  • APOBEC2 deficiency up-regulates myoblast differentiation Reviewed

    Ohtsubo, H, Sato, Y, Suzuki, T, Mizunoya, W, Nakamura, M, Tatsumi, R, Ikeuchi, Y

    2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells” Steamboat Springs, CO, USA   2014.7

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    APOBEC2 deficiency up-regulates myoblast differentiation
    Poster Presentation

  • Sema3A secreted from satellite cells promotes slow-twitch fiber generation

    Suzuki, T, Ohya, Y, Ojima, K, Mizunoya, W, Sawano, S, Ohtsubo, H, Nishimatsu, S, Anderson, J. E, Do, M.-K. Q, Nakamura, M, Furuse, M, Ikeuchi, Y, Nohno, T, Tatsumi, R

    2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells” Steamboat Springs, CO, USA   2014.7

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    Sema3A secreted from satellite cells promotes slow-twitch fiber generation
    Poster Presentation

  • M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression Reviewed

    Tatsumi, R, Sakaguchi, S, Shono, J, Suzuki, T, Sawano, S, Anderson, J.E, Do, M.-K.Q, Ohtsubo, H, Mizunoya, W, Nakamura, M, Furuse, M, Ikeuchi, Y

    2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells” Steamboat Springs, CO, USA   2014.7

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    M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression
    Poster Presentation

  • ポリフェノールによる遅筋型筋線維の形成誘導に関する研究 Reviewed

    辰巳隆一, 鈴木貴弘, 赤星眞理子, 大屋雄暉, 水野谷航, 中村真子, 池内義秀

    東和食品研究振興会 平成26年度「助成研究成果報告書」   2014.4

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  • Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation Reviewed

    Suzuki, T, Ojima, K, Do, M.K.Q, Hara, M, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, J.E, Tatsumi, R

    2013 EMBO Workshop on “Semaphorin Function and Mechanism in Action”, Cemay-la-Ville, France   2013.10

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    Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation
    Poster Presentation

  • Heparan/chondroitin sulfate chains may mediate HGF/FGF2-induced up-regulation of neural chemorepellent Sema3A in satellite cell cultures Reviewed

    Do, M.Q, Shimizu, N, Suzuki, T, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, J.E, Tatsumi, R

    2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells”, Renaissance Tuscany Il Ciocco Resort & Spa, Barga, Lucca, Italy   2012.8

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    Heparan/chondroitin sulfate chains may mediate HGF/FGF2-induced up-regulation of neural chemorepellent Sema3A in satellite cell cultures
    Poster presentation

  • Semaphorin 3A regulates the early differentiation of satellite cells Reviewed

    Suzuki, T, Ojima, K, Do, M.Q, Hara, M, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, J.E, Tatsumi, R

    Semaphorin 3A regulates the early differentiation of satellite cells. 2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells”, Renaissance Tuscany Il Ciocco Resort & Spa, Barga, Lucca, Italy   2012.8

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    Semaphorin 3A regulates the early differentiation of satellite cells
    Poster presentation

  • Mechano-Sensing Calcium-Influx Machinery that Instigates Skeletal Muscle Satellite Cell Activation Reviewed

    Tatsumi, R, Hara, M, Tabata, K, Suzuki, T, Do, M.-K. Q, Mizunoya, W, Nakamura, M, Ikeuchi, Y, Anderson, J. E, Allen, R. E

    2012 FASEB Science Research Conference on “Skeletal Muscle Satellite & Stem Cells”, Renaissance Tuscany Il Ciocco Resort & Spa, Barga, Lucca, Italy   2012.8

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    Mechano-Sensing Calcium-Influx Machinery that Instigates Skeletal Muscle Satellite Cell Activation
    Selected for Oral presentation

  • Possible implication of satellite cells in regenerative motoneuritogenesis: HGF and FGF2 up-regulate neural chemorepellent Sema3A expression

    Tatsumi, R, Do, M. Q, Shimizu, N, Sankoda, Y, Anderson, J. E, Sato, Y, Suzuki, T, Mizunoya, W, Ikeuchi, Y, Allen, R. E, qual contributors

    Theme 3: Tissue Mechanics, Track 3.6 Muscle Mechanics and Motor Control, at the 6th World Congress on Biomechanics (WCB) 2010, in conjunction with the 14th International Conference on Biomedical Engineering (ICBME) 2010 and the 5th Asian Pacific Conferenc   2010.8

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    Possible Implication of Satellite Cells in Regenerative Motoneuritogenesis: HGF and FGF2 Upregulate Neural Chemorepellent Sema3A Expression.
    Poster presentation

  • Possible implication of satellite cells in regenerative motoneuritogenesis : Temporal coordination of HGF/FGF2/TGF-beta may regulate neural chemorepellent Sema3A.

    Do, M-KQ, Shimizu, N, Suzuki, T, Tatsumi, R, Mizunoya, W, Ikeuchi, Y, Anderson, JE, Allen, RE

    Proceeding of 2010 FASEB Summer Research Conference on Skeletal Muscle Satellite & Stem Cells.   2010.7

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  • A Possible Role for Satellite Cells in Regenerative Motoneurogenesis: HGF Up-Regulates Neural Chemorepellent Sema3A Expression Reviewed

    Tatsumi, R, Sankoda, Y, Anderson, J. E, Sato, Y, Mizunoya, W, Shimizu, N, Suzuki, T, Yamada, M, Rhoads, R. P., Jr, Ikeuchi, Y, Allen, R. E

    Making Muscle and the Embryo and Adult, A Joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells, Alfred Lerner Hall at Columbia University, New York, US   2009.5

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    A Possible Role for Satellite Cells in Regenerative Motoneurogenesis: HGF Up-Regulates Neural Chemorepellent Sema3A Expression
    Poster presentation

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Professional Memberships

  • 日本栄養・食糧学会

  • 日本分子生物学会

  • 日本筋学会

  • 日本暖地畜産学会

  • 日本食肉科学会

  • 日本畜産学会

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Committee Memberships

  • 畜産学教育協議会   事務局   Domestic

    2023.10 - 2026.9   

  • 畜産学教育協議会   幹事(庶務、会計)  

    2023.10 - 2026.9   

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  • 日本暖地畜産学会   Organizer   Domestic

    2023.10 - 2024.9   

  • 日本暖地畜産学会   県幹事(福岡県)  

    2023.10 - 2024.9   

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  • 日本食肉科学会   会計  

    2023.4 - Present   

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    Committee type:Academic society

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  • 日本食肉科学会   広報委員  

    2021.4 - 2023.3   

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    Committee type:Academic society

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  • 日本畜産学会若手企画委員会   委員  

    2018.4 - 2024.3   

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    Committee type:Academic society

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Academic Activities

  • 世話人

    第9回 若手による骨格筋細胞生物学研究会  ( Japan ) 2024.11

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    Type:Competition, symposium, etc. 

  • オーガナイザー

    第78 回日本栄養・食糧学会大会 シンポジウム SY01「シン・Nutrition in Myology」  ( Japan ) 2024.5

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  • 実行委員会委員(プログラム委員)

    第78 回日本栄養・食糧学会大会  ( Japan ) 2024.5

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  • オーガナイザー

    日本畜産学会第131回大会 関連シンポジウム:骨格筋を基礎的な観点から再考する学術フォーラム「骨格筋の量と質を制御する分子機構と畜産学への応用」  ( Japan ) 2023.9

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    Type:Competition, symposium, etc. 

  • 世話人

    公社)日本畜産学会 若手企画委員会主催ランチョンセミナー 第26 回若手企画シンポジウム(一般財団法人旗影会協賛)「どうする?どうなる!? 日本の畜産業界 〜現状と現場を知る〜」  ( Japan ) 2023.9

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • 行事・接遇委員 International contribution

    the 68th International Congress of Meat Science and Technology  ( Kobe Japan ) 2022.8

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  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

    Number of peer-reviewed articles in Japanese journals:1

  • 実行委員会 庶務担当

    第14回 日本暖地畜産学会大会 (福岡大会)  ( Japan ) 2021.10

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  • 大会実行委員会 委員(実行委員長補佐)

    日本畜産学会 第128回大会  ( Japan ) 2021.3

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  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Number of peer-reviewed articles in Japanese journals:1

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

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Research Projects

  • 健康長寿遺伝子の同定と発現誘導:健康寿命延伸戦略のブレークスルー

    Grant number:24K01911  2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    辰巳 隆一, 鈴木 貴弘

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    タンパク質のニトロ化(特定のチロシン残基にニトロ基が導入される翻訳後修飾)が、アルツハイマー病やパーキンソン病などの神経変性疾患、アテローム性動脈硬化症などの加齢関連疾病と関係があることが示唆されている。本研究代表者は、ADL・QOL低下のリスク因子である加齢性筋萎縮・再生不全の新奇主要因として、筋幹細胞の活性化因子HGF(肝細胞増殖因子)のニトロ化・不活化を見出した。原因タンパク質のニトロ化を解除できれば (脱ニトロ化)、加齢関連疾患の予防や治療が可能になると期待される。そこで本研究では、健康長寿遺伝子と期待される脱ニトロ化酵素遺伝子と発現細胞の同定および食品機能学的発現誘導を目指す。

    CiNii Research

  • 2023年度 一般財団法人旗影会 研究助成

    2023

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    Grant type:Donation

  • 多機能性因子の合成を介した筋衛星細胞による自律的な筋肥大誘導機構の解釈を利用した新プラットフォームの形成(Ⅱ)

    2023

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    Grant type:Donation

  • Satellite cells functional-heterogeneity according to mice strains

    Grant number:22K05955  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    鈴木 貴弘

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    Authorship:Principal investigator  Grant type:Scientific research funding

    本研究は、野生型マウス系統間という比較基準のもとで、筋幹細胞(衛星細胞)の機能的不均一性を捉えることを目標とする。衛星細胞には、筋再生に留まらず筋肥大にも寄与する高いポテンシャルをもつ細胞集団と、対極な性質を示す集団とが存在すると考えられている。そこで、それぞれの細胞集団を保有する系統を正確に見極め、かつ各特性の解明に繋がる基礎的知見の捻出を目指す。本研究から得られる知見は、系統間でポテンシャルが異なる可能性を示すので、衛星細胞をターゲットとした筋生理学的研究を行う際に適切な系統を選択するための有益な情報となる。さらに、成熟個体における効率的な筋肥大誘導の技術開発へ学術的な発展も期待される。

    CiNii Research

  • 動物の系統間における筋幹細胞の機能的不均一性を捉える

    2022 - 2024

    令和4年度科学研究費助成事業(学術研究助成基金助成金)(「基盤研究(C)」,及び「若手研究」における独立基盤形成支援(試行))研究基盤整備 Ⅱ

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 多機能性因子の合成を介した筋衛星細胞による自律的な筋肥大誘導機構の解釈を利用した新プラットフォームの形成

    2022

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    Grant type:Donation

  • 衛星細胞で合成されるnetrin-4は筋芽細胞の融合を活発にする(Netrin-4 synthesized in satellite cell-derived myoblasts stimulates autonomous fusion)

    2022

    令和4年度 外国語論文校閲経費支援(基礎支援)

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 物理刺激によって発現が誘導される筋細胞由来低分子化合物の生理作用の検討

    2021.10 - 2026.3

    Joint research

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 加齢性筋萎縮・再生不全の先駆的理解と栄養機能学的制御

    Grant number:21H02347  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    辰巳 隆一, 中島 崇, 鈴木 貴弘, 前原 一満

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    代表者はこれまでに、骨格筋の肥大・再生・維持を妨げる「筋幹細胞の活性化阻害機構」として活性化因子 HGFのニトロ化 (不活化) を見出した。一方、加齢に伴い筋細胞が萎縮する他、線維化や脂肪化も散見される。 本研究では、これらの加齢性変化が上記の「HGFのニトロ化」に起因すると着想し、これを新規ツール(ニトロ化HGFに対する抗体)を用いて検証する。また、加齢性筋萎縮・再生不全の積極的な治療法・予防法の創出を目指して、脱ニトロ化酵素遺伝子の同定に挑戦すると共に、この遺伝子の発現誘導およびニトロ化を抑制する機能性食品成分を検索する。以って愛玩動物(およびヒト)の健康寿命の延伸に寄与することを目指す。

    CiNii Research

  • 筋線維型に応じて変化する筋幹細胞の特性獲得メカニズムの検証

    2021

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    Grant type:Donation

  • 令和2年度研究奨励金/小児期の筋成長・肥大プロセスでの筋幹細胞による自律的な筋線維型制御機構の解明

    2021

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    Grant type:Donation

  • 新生筋線維の筋線維型初期決定機構の要を担う筋幹細胞の同定

    2021

    令和3年度 大学院農学研究院若手教員 支援事業 [チャレンジ研究支援(I型)]

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • ヒラメ筋よりも長趾伸筋由来の衛星細胞(筋芽細胞)で多量に合成されるnetrin-1は速筋型筋管の形成を誘導する(Abundant Synthesis of Netrin-1 in Satellite Cell-Derived Myoblasts Isolated from EDL Rather Than Soleus Muscle Regulates Fast-Type Myotube Formation)

    2021

    令和3年度研究活動基礎支援制度「外国語校閲経費支援」

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 骨格筋肥大・萎縮の根幹である筋原線維構造の形成・維持・分解メカニズムの解明

    Grant number:19H03100  2019 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 筋幹細胞が自律的に筋線維型を初期決定する分子メカニズムの解明

    Grant number:19K15959  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 成熟後の効率的な筋肥大の誘導に寄与する筋幹細胞の探索(II)

    2019

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    Grant type:Donation

  • 難治性疾患実用化研究事業「デュシェンヌ型筋ジストロフィーに対する革新的ペプチド医薬の実用化」

    2018.4 - 2021.3

    Research commissions

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    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 成熟後の効率的な筋肥大の誘導に寄与する筋幹細胞の探索

    2018

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    Grant type:Donation

  • 骨格筋発達の統合的理解を目指す異種細胞間コミュニケーション機構の全容解明

    Grant number:16H02585  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Scientific research funding

  • 多様な筋幹細胞による新奇筋線維型制御機構の解明

    Grant number:16K18788  2016 - 2018

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 筋幹細胞の分泌因子による筋線維型自律制御機構の解明

    Grant number:14J09964  2014 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 神経軸索成長ガイダンス因子による筋肥大・再生制御機構

    Grant number:12J02624  2012 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Educational Activities

  • 教育活動の概要:
     学部の教育に関しては、実験科目として「基礎化学実験(2年次後期、必修)[分担]」および「畜産化学実験(3年次通年、選択必修)[主担当]」を担当し、実験を行う上で基礎的な心構えや技術を分りやすく説明するよう努めています。授業科目としては、「動物生産科学概論(2年次後期、必修)」および「Utilization of Animal and Marine Resource(3年次前期、専門科目)」の専攻教育科目を分担しています。学府の授業科目として、「筋肉・食肉科学特論(修士1年秋学期、選択)」の専攻教育科目を分担しています。

Class subject

  • 基礎化学実験(分担)

    2024.10 - 2025.3   Second semester

  • 動物・海洋生物科学演習第二

    2024.10 - 2025.3   Second semester

  • 動物・海洋生物科学演習第一

    2024.10 - 2025.3   Second semester

  • 動物・海洋生物科学プロジェクト演習

    2024.10 - 2025.3   Second semester

  • 筋肉・食肉科学特論

    2024.10 - 2024.12   Fall quarter

  • 卒業研究

    2024.4 - 2025.3   Full year

  • 動物・海洋生物科学特別演習

    2024.4 - 2025.3   Full year

  • 動物・海洋生物科学特別講究

    2024.4 - 2025.3   Full year

  • 動物・海洋生物科学特別実験

    2024.4 - 2025.3   Full year

  • プロジェクト演習

    2024.4 - 2025.3   Full year

  • ティーチング演習

    2024.4 - 2025.3   Full year

  • 国際交流演習Ⅳ

    2024.4 - 2025.3   Full year

  • 国際交流演習Ⅲ

    2024.4 - 2025.3   Full year

  • 国際交流演習Ⅱ

    2024.4 - 2025.3   Full year

  • 国際交流演習Ⅰ

    2024.4 - 2025.3   Full year

  • 国際演示技法

    2024.4 - 2025.3   Full year

  • 演示技法Ⅱ

    2024.4 - 2025.3   Full year

  • 演示技法Ⅰ

    2024.4 - 2025.3   Full year

  • インターンシップ

    2024.4 - 2025.3   Full year

  • 動物海洋生物科学ティーチング演習

    2024.4 - 2025.3   Full year

  • 動物・海洋生物科学特別研究第二

    2024.4 - 2025.3   Full year

  • 動物・海洋生物科学特別研究第一

    2024.4 - 2025.3   Full year

  • 畜産化学実験

    2024.4 - 2024.9   First semester

  • Utilization of Animal and Marine Resource(分担)

    2024.4 - 2024.9   First semester

  • 基礎化学実験(分担)

    2023.10 - 2024.3   Second semester

  • 動物生産科学概論(分担)

    2023.10 - 2024.3   Second semester

  • 動物・海洋生物科学プロジェクト演習

    2023.10 - 2024.3   Second semester

  • 動物・海洋生物科学演習第二

    2023.10 - 2024.3   Second semester

  • 動物・海洋生物科学演習第一

    2023.10 - 2024.3   Second semester

  • 筋肉・食肉科学特論

    2023.10 - 2023.12   Fall quarter

  • 卒業研究

    2023.4 - 2024.3   Full year

  • 動物・海洋生物科学特別演習

    2023.4 - 2024.3   Full year

  • 動物・海洋生物科学特別講究

    2023.4 - 2024.3   Full year

  • 動物・海洋生物科学特別実験

    2023.4 - 2024.3   Full year

  • プロジェクト演習

    2023.4 - 2024.3   Full year

  • ティーチング演習

    2023.4 - 2024.3   Full year

  • 国際交流演習Ⅳ

    2023.4 - 2024.3   Full year

  • 国際交流演習Ⅲ

    2023.4 - 2024.3   Full year

  • 国際交流演習Ⅱ

    2023.4 - 2024.3   Full year

  • 国際交流演習Ⅰ

    2023.4 - 2024.3   Full year

  • 国際演示技法

    2023.4 - 2024.3   Full year

  • 演示技法Ⅱ

    2023.4 - 2024.3   Full year

  • 演示技法Ⅰ

    2023.4 - 2024.3   Full year

  • インターンシップ

    2023.4 - 2024.3   Full year

  • 動物海洋生物科学ティーチング演習

    2023.4 - 2024.3   Full year

  • 動物・海洋生物科学特別研究第二

    2023.4 - 2024.3   Full year

  • 動物・海洋生物科学特別研究第一

    2023.4 - 2024.3   Full year

  • 畜産化学実験

    2023.4 - 2023.9   First semester

  • Utilization of Animal and Marine Resource(分担)

    2023.4 - 2023.9   First semester

  • 基礎化学実験(分担)

    2022.10 - 2023.3   Second semester

  • 動物・海洋生物科学演習第二

    2022.10 - 2023.3   Second semester

  • 動物・海洋生物科学演習第一

    2022.10 - 2023.3   Second semester

  • 動物・海洋生物科学プロジェクト演習

    2022.10 - 2023.3   Second semester

  • 筋肉・食肉科学特論(分担)

    2022.10 - 2022.12   Fall quarter

  • 卒業研究

    2022.4 - 2023.3   Full year

  • 動物・海洋生物科学特別演習

    2022.4 - 2023.3   Full year

  • 動物・海洋生物科学特別講究

    2022.4 - 2023.3   Full year

  • 動物・海洋生物科学特別実験

    2022.4 - 2023.3   Full year

  • プロジェクト演習

    2022.4 - 2023.3   Full year

  • ティーチング演習

    2022.4 - 2023.3   Full year

  • 国際交流演習Ⅳ

    2022.4 - 2023.3   Full year

  • 国際交流演習Ⅲ

    2022.4 - 2023.3   Full year

  • 国際交流演習Ⅱ

    2022.4 - 2023.3   Full year

  • 国際交流演習Ⅰ

    2022.4 - 2023.3   Full year

  • 国際演示技法

    2022.4 - 2023.3   Full year

  • 演示技法Ⅱ

    2022.4 - 2023.3   Full year

  • 演示技法Ⅰ

    2022.4 - 2023.3   Full year

  • インターンシップ

    2022.4 - 2023.3   Full year

  • 動物海洋生物科学ティーチング演習

    2022.4 - 2023.3   Full year

  • 動物・海洋生物科学特別研究第二

    2022.4 - 2023.3   Full year

  • 動物・海洋生物科学特別研究第一

    2022.4 - 2023.3   Full year

  • 畜産化学実験

    2022.4 - 2022.9   First semester

  • Utilization of Animal and Marine Resource(分担)

    2022.4 - 2022.9   First semester

  • 基礎化学実験(分担)

    2021.10 - 2022.3   Second semester

  • 動物・海洋生物科学演習第二

    2021.10 - 2022.3   Second semester

  • 動物・海洋生物科学プロジェクト演習

    2021.10 - 2022.3   Second semester

  • 動物・海洋生物科学演習第一

    2021.10 - 2022.3   Second semester

  • 専門英語(分担)

    2021.10 - 2022.3   Second semester

  • 実地見学(アニマルサイエンス分野)

    2021.10 - 2022.3   Second semester

  • 動物生産科学概論(分担)

    2021.10 - 2022.3   Second semester

  • 筋肉・食肉科学特論(分担)

    2021.10 - 2021.12   Fall quarter

  • アカデミックフロンティアII(分担)

    2021.6 - 2021.8   Summer quarter

  • 畜産化学実験

    2021.4 - 2022.3   Full year

  • 動物・海洋生物科学特別演習

    2021.4 - 2022.3   Full year

  • 動物・海洋生物科学特別講究

    2021.4 - 2022.3   Full year

  • プロジェクト演習

    2021.4 - 2022.3   Full year

  • ティーチング演習

    2021.4 - 2022.3   Full year

  • 動物・海洋生物科学特別実験

    2021.4 - 2022.3   Full year

  • 動物・海洋生物科学特別研究第二

    2021.4 - 2022.3   Full year

  • 動物・海洋生物科学特別研究第一

    2021.4 - 2022.3   Full year

  • 国際交流演習Ⅳ

    2021.4 - 2022.3   Full year

  • 国際交流演習Ⅲ

    2021.4 - 2022.3   Full year

  • 国際交流演習Ⅱ

    2021.4 - 2022.3   Full year

  • 国際交流演習Ⅰ

    2021.4 - 2022.3   Full year

  • 国際演示技法

    2021.4 - 2022.3   Full year

  • 演示技法Ⅱ

    2021.4 - 2022.3   Full year

  • 演示技法Ⅰ

    2021.4 - 2022.3   Full year

  • インターンシップ

    2021.4 - 2022.3   Full year

  • 動物海洋生物科学ティーチング演習

    2021.4 - 2022.3   Full year

  • 卒業研究

    2021.4 - 2022.3   Full year

  • Utilization of Animal and Marine Resource(分担)

    2021.4 - 2021.9   First semester

  • 動物生産科学概論(分担)

    2020.10 - 2021.3   Second semester

  • 動物・海洋生物科学演習第二

    2020.10 - 2021.3   Second semester

  • 動物・海洋生物科学演習第一

    2020.10 - 2021.3   Second semester

  • 動物・海洋生物科学プロジェクト演習

    2020.10 - 2021.3   Second semester

  • 筋肉・食肉科学特論(分担)

    2020.10 - 2020.12   Fall quarter

  • 畜産化学実験

    2020.4 - 2021.3   Full year

  • 動物・海洋生物科学特別演習

    2020.4 - 2021.3   Full year

  • 動物・海洋生物科学特別講究

    2020.4 - 2021.3   Full year

  • プロジェクト演習

    2020.4 - 2021.3   Full year

  • ティーチング演習

    2020.4 - 2021.3   Full year

  • 動物・海洋生物科学特別実験

    2020.4 - 2021.3   Full year

  • 動物・海洋生物科学特別研究第二

    2020.4 - 2021.3   Full year

  • 動物・海洋生物科学特別研究第一

    2020.4 - 2021.3   Full year

  • 国際交流演習Ⅳ

    2020.4 - 2021.3   Full year

  • 国際交流演習Ⅲ

    2020.4 - 2021.3   Full year

  • 国際交流演習Ⅱ

    2020.4 - 2021.3   Full year

  • 国際交流演習Ⅰ

    2020.4 - 2021.3   Full year

  • 国際演示技法

    2020.4 - 2021.3   Full year

  • 演示技法Ⅱ

    2020.4 - 2021.3   Full year

  • 演示技法Ⅰ

    2020.4 - 2021.3   Full year

  • インターンシップ

    2020.4 - 2021.3   Full year

  • 動物海洋生物科学ティーチング演習

    2020.4 - 2021.3   Full year

  • 筋肉・食肉科学特論

    2024.10 - 2024.12   Fall quarter

  • 畜産化学実験

    2024.4 - 2024.9   First semester

▼display all

FD Participation

  • 2023.11   Role:Participation   Title:農学研究院FD:遺伝子組換え実験の安全管理について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.9   Role:Participation   Title:M2Bシステムの使い方 ~Moodleのバージョンアップによる変更点を中心に紹介します~(9/13)

    Organizer:University-wide

  • 2023.3   Role:Participation   Title:TF(ティーチング・フェロー)経験を通じて大学院生の教育能力を高める

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role:Participation   Title:新M2Bシステムの使い方 ~新機能を中心に紹介します~(3/17)

    Organizer:University-wide

  • 2022.3   Role:Participation   Title:農学研究院FD:リポジトリ登録を対象とした大学改革推進経費の新指標案について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role:Participation   Title:全学FD:メンタルヘルス講演会

    Organizer:University-wide

  • 2021.11   Role:Participation   Title:農学研究院FD「人を対象とする生命科学・医学系研究に関する倫理指針」について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.9   Role:Participation   Title:JST 次世代研究者挑戦的研究プログラム 説明会

    Organizer:University-wide

  • 2021.7   Role:Participation   Title:農学研究院FD「科研費を獲りにいこう! 科研費獲得の技術と工夫」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.4   Role:Participation   Title:オンライン授業実施の”いろは”

    Organizer:University-wide

  • 2021.4   Role:Participation   Title:令和3年度 第1回全学FD(新任教員の研修)

    Organizer:University-wide

  • 2020.12   Role:Participation   Title:大学の研究評価の現状と農学研究院の「部局独自の評価基準」案における業績分析

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all