平成２９年度科学技術分野の文部科学大臣表彰科学技術賞（研究部門）

2017.4   文部科学省   緑茶成分の生理作用の分子基盤に関する研究

第２１回安藤百福賞優秀賞

2017.3   安藤スポーツ・食文化振興財団食創会   「緑茶カテキン受容体の基礎研究」

農芸化学技術賞

2016.3   日本農芸化学会   健康機能を有する緑茶「べにふうき」の効果、作用機序、茶葉特性の解明ならびに飲食品の開発

日本食品免疫学会学会賞

2010.6   日本食品免疫学会   食品免疫学の基礎および応用分野における成果に対して。

日本学術振興会賞

2006.3   日本学術振興会   茶葉成分の生理作用の分子機構に関する研究

日本農学進歩賞

2004.11   日本農学会   機能性食品成分の分子標的の同定とその作用機構に関する研究

農芸化学奨励賞

1998.3   日本農芸化学会   ヒト抗体機能の多面的制御に関する研究

九州大学共同研究等活動表彰

2023.11   九州大学   共同研究費の獲得上位者として

VISION EXPO 産学官連携活動特別表彰

2022.11   九州大学   共同研究費の獲得上位者として

九州大学共同研究等活動表彰

2022.11   九州大学   共同研究費の獲得に対して

日本栄養・食糧学会2022年度大会トピックス賞

2022.6   日本栄養・食糧学会   研究成果発表に対して

九州大学共同研究等活動表彰

2021.11   日本農芸化学会   共同研究費の獲得に対して

日本農芸化学会 トピックス賞

2021.4   日本農芸化学会   ウーロン茶ポリフェノールの機能性発現メカニズムについて

日本農芸化学会 トピックス賞

2021.4   日本農芸化学会   植物マイクロRNAの新規機能性の発見に対して

九州大学共同研究等活動表彰

2020.11   九州大学   九州大学共同研究等活動

九州大学共同研究等活動表彰

2019.11   九州大学   九州大学共同研究等活動

九州大学農学研究院賞

2018.2   九州大学農学研究院  

Hot Topics Award at Annual Meeting of JSBBA 2017

2017.3   日本農芸化学会   「緑茶カテキンEGCGのがん幹細胞抑制作用に関与する分子の同定」

Hot Topics Award at Annual Meeting of JSBBA 2017

2017.3   日本農芸化学会   「新規膵臓がん幹細胞制御分子の同定」

ＨＫ創造性開発賞最優秀賞

2017.2   九州大学農学部   優秀特許表彰

九州大学研究活動表彰

2016.11   九州大学  

第一回食品免疫産業賞

2016.11   日本食品免疫学会   緑茶の抗アレルギー成分を特定し、その作用機構を解明して応用開発につなげる成果を挙げた

九州大学研究活動表彰

2015.11   九州大学   研究活動表彰

Hot Topics Award at Annual Meeting of JSBBA 2015

2015.3   日本農芸化学会  

九州大学研究活動表彰

2014.11   九州大学  

九州大学研究活動表彰

2013.11   九州大学  

九州大学研究活動表彰

2012.11   九州大学  

O-CHAパイオニア賞学術研究大賞

2012.11   世界緑茶協会   緑茶の生活習慣病予防効果に関する研究と茶業振興への取組において

平成23年度九州大学研究活動表彰

2011.11   九州大学  

ＨＫ創造性開発賞最優秀賞

2009.3   九州大学農学部   優秀特許表彰

農学研究院賞

2006.7   九州大学農学部  

ICOS2004 Outstanding Poster Award

2004.11   国際O-CHA学術会議2004   カテキン(EGCG)が抗がん作用を発揮するための受容体の発見

67-kDa laminin receptor mediates oolonghomobisflavan B-induced cell growth inhibition in melanoma Reviewed International coauthorship International journal

@Jaehoon Bae,@Motofumi Kumazoe,#Kwanwoo Lee,@Yoshinori Fujimura and@Hirofumi Tachibana

Phytomedicine   118   154970 - 154970   2023.9

5,7-dimethoxyflavone potentiates epigallocatechin-3-O-gallate-induced cancer cell death in multiple myeloma cells Reviewed International coauthorship International journal

@Jaehoon Bae,@Motofumi Kumazoe,@Su-Jin Park,@Yoshinori Fujimura,@Hirofumi Tachibana

FEBS Open Bio.   13   2147 - 2156   2023.9

Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by inhibition of neuronal maturation in adolescent mice Reviewed International journal

#Kwanwoo Lee,@Motofumi Kumazoe,#Yuki Marugame,@Yoshinori Fujimura, and@Hirofumi Tachibana

Biochem. Biophys. Res. Commun.   669   46 - 53   2023.6

Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1 Reviewed International journal

@Motofumi Kumazoe,@Fumiyo Ogawa,@Ai Hikida,#Yu Shimada,@Ren Yoshitomi,#Ryoya Watanabe,@Yoshinori Fujimura, and@Hirofumi Tachibana

Sci. Rep.   13   2128   2023.2

(-)-Epigallocatechin-3-O-gallate upregulated the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells Reviewed International journal

@Motoki Murata,#Yuki Marugame,@Mai Morozumi,@Kyosuke Murata,@Motofumi Kumazoe,@Yoshinori Fujimura, and@Hirofumi Tachibana

Biomedical Reports   18   19   2023.1

Quercetin up-regulates the expression of tumor-suppressive miRNAs in human cervical cancer Reviewed International journal

@Motoki Murata,@Satomi Komatsu,@Emi Miyamoto,@Chihiro Oka,Ichian Lin,@Motofumi Kumazoe,@Shuya Yamashita,@Yoshinori Fujimura, and @Hirofumi Tachibana

Bioscience of Microbiota, Food and Health   42   87 - 93   2023.1

Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin Reviewed International journal

@Yoshinori Fujimura,@Takanori Yoshimoto,@Konatsu Fujino,@Ayaka Nezu,#Yuki Marugame,@Jaehoon Bae,@Motofumi Kumazoe, and@Hirofumi Tachibana

J. Nat. Med.   77   363 - 369   2022.12

Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase Reviewed International journal

＠Daiki Hayashi,＠Varnavas D. Mouchlis,＠Seika Okamoto,＠Liuqing Wang,＠Sheng Li,＠Shuji Ueda,＠Minoru Yamanoue,＠Hirofumi Tachibana, ＠Hiroyuki Arai,＠Hitoshi Ashida,＠Edward A. Dennis, and＠Yasuhito Shirai

J. Nutr. Biochem   110   109129   2022.12

Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells Reviewed International journal

@Jaehoon Bae,#Kwanwoo Lee,@Ji Sun Park,@Jinseok Jung,@Hirofumi Tachibana,@Yoshinori Fujimura,@Motofumi Kumazoe,@Jae Sung Lim,@Young-Chang Cho,@Seung-Jae Lee and @Su-Jin Park

Curr. Issues Mol. Biol.   44   6247 - 6256   2022.12

Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment Reviewed International journal

＠Tomomi Morikawa-Ichinose,＠Yoshinori Fujimura,＠Motofumi Kumazoe,＠Hiroaki Onda,＠Daisuke Miura,＠Hirofumi Tachibana

Food and Chemical Toxicology   169   113421   2022.9

Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice Reviewed International journal

@Motoki Murata,@Kai Nakayama,@Ryo Kitamura,@Megumi Goto,@Mai Morozumi,@Takanori Yoshimoto,#Yuki Marugame,@Ren Yoshitomi,@Shuya Yamashita,@Yoshinori Fujimura, and @Hirofumi Tachibana

Int. J.Gastronomy and Food Science   29   100573   2022.9

Circulating miRNA profiles in mice plasma following flavonoid intake Reviewed International journal

＠Motoki Murata,＃Yuki Marugame,＠Shuhei Yamada,＠I-Chian Lin,＠Shuya Yamashita,＠Yoshinori Fujimura, and＠Hirofumi Tachibana

Mol. Biol. Rep.   49   10399 - 10407   2022.9

Myricetin improve cognitive function in SAMP8 mice accompanied with upregulation of BDNF and NGF Reviewed International journal

#Yu Shimada,@Yuka Sato,@Motofumi Kumazoe,@Ryo Kitamura,@Yoshinori Fujimura, and@Hirofumi Tachibana

Biochem. Biophys. Res. Commun.   616   33 - 40   2022.5

Metabolic profiling for evaluating the dipeptidyl peptidase-IV inhibitory potency of diverse green tea cultivars and determining bioactivity-related ingredients and combinations Reviewed International journal

@Yoshinori Fujimura,@Mototsugu Watanabe,@Tomomi Morikawa-Ichinose,@Konatsu Fujino,#Mao Yamamoto,@Seita Nishioka,@Chihiro Inoue, @Fumiyo Ogawa,@Madoka Yonekura,@Akari Nakasone,@Motofumi Kumazoe, and@Hirofumi Tachibana

J. Agri. Food Chem   70   6455 - 6466   2022.5

Fustin, a flavanonol, synergically potentiates the anti-cancer effect of the green tea catechin EGCG with activation of the eNOS/cGMP axis Reviewed International journal

@Motofumi Kumazoe,@Yoshinori Fujimura,@Ren Yoshitomi,#Yu Shimada,and @Hirofumi Tachibana

J. Agri. Food Chem   70   3458 - 3466   2022.2

Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner Reviewed International journal

@Shuya Yamashita,@Ichian Lin,@Chihiro Oka,@Motofumi Kumazoe,@Satomi Komatsu,@Motoki Murata,@Shoko Kamachi,and@Hirofumi Tachibana

J. Nutr. Biochem.   100   108910   2022.2

Sesame Lignans Upregulate Glutathione S-transferase Expression and Downregulate microRNA-669c-3p Reviewed International journal

#Yuki Marugame,@Natsuko Takeshita,@Shuhei Yamada,@Ren Yoshitomi,@Motofumi Kumazoe,@Yoshinori Fujimura and @Hirofumi Tachibana

Bioscience of Microbiota, Food and Health   41   66 - 72   2022.1

Methylated (−)-epigallocatechin 3-O-gallate potentiates split vaccine accompanied with upregulation of Toll-like receptor 5 Reviewed International journal

@Motofumi Kumazoe,@Kanako Takamatsu,@Fuyumi Horie,#Ren Yoshitomi,@Hiroki Hamagami,@Hiroshi Tanaka,@Yoshinori Fujimura,@Hirofumi Tachibana

Sci. Rep.   11   23101   2021.11

The combined effect of green tea and α-glucosyl hesperidin in preventing obesity:a randomized placebo-controlled clinical trial Reviewed International journal

#Ren Yoshitomi, #Mao Yamamoto, #Motofumi Kumazoe, @Yoshinori Fujimura, @Madoka Yonekura, @Yasuyo Shimamoto, @Akari Nakasone, @Satoshi Kondo, @Hiroki Hattori, @Akane Haseda, @Jun Nishihira, @Hirofumi Tachibana

Sci. Rep.   11   19067   2021.9

Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG Reviewed International journal

@Motofumi Kumazoe, @Yasutake Tanaka, #Ren Yoshitomi, #Yuki Marugame, #Kwan-Woo Lee, @Hiroaki Onda, @Yoshinori Fujimura, @Madoka Yonekura, @Yasuyo Shimamoto, @Hirofumi Tachibana

J. Natural Medicines   75   1037 - 1042   2021.7

Eriodictyol-amplified 67-kDa laminin receptor signaling potentiates the anti-allergic effect of O-methylated catechin Reviewed International journal

@Yoshinori Fujimura, #Konatsu Fujino, #Takanori Yoshimoto, #Ayaka Nezu, #Yuki Marugame, @Jaehoon Bae, @Motofumi Kumazoe, @Hirofumi Tachibana

J. Natural Products   84   1823 - 1830   2021.7

Oral EGCG administration time-dependently increases plasma cGMP concentration in mice Reviewed International journal

@Yasutake Tanaka,@Motofumi Kumazoe,@Hiroaki Onda,@Yoshinori Fujimura, and@Hirofumi Tachibana

Food Bioscience   41   101017   2021.6

Immunomodulatory effect of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in allergic conditions in vitro and in vivo Reviewed International journal

@Akira Iwamoto,@Yuichi Inoue,@Hirofumi Tachibana,@Hiroharu Kawahara

Cytotechnology   73   333 - 342   2021.6

Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3 Reviewed International journal

#Ren Yoshitomi,@Kai Nakayama,@Shuya Yamashita,@Motofumi Kumazoe,@Ting-An Lin,@Chen-Yi Mei,#Yuki Marugame,@Yoshinori Fujimura,@Mari Maeda-Yamamoto,@Shinichi Kuriyama, and@Hirofumi Tachibana

Sci. Rep.   10 ( 1 )   10283   2020.12

Src mediates epigallocatechin-3-O-gallate-elicited acid Reviewed International journal

@Motofumi Kumazoe,@Mai Kadomatsu,@Jaehoon Bae,#Yushi Otsuka, @Yoshinori Fujimura, and @Hirofumi Tachibana

Molecules   25 ( 22 )   5481   2020.11

EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol Reviewed International journal

@Motoki Murata,@Yuki Shimizu,#Yuki Marugame,@Ayaka Nezu,@Konatsu Fujino,@Syuhei Yamada,@Motofumi Kumazoe,@Yoshinori Fujimura, and @Hirofumi Tachibana

J. Natural Medicines   74 ( 4 )   637 - 679   2020.5

Procyanidin C1 inhibits melanoma cell growth by activating 67-kDa laminin receptor signaling Reviewed International journal

Jaehoon Bae, Motofumi Kumazoe, Kyosuke Murata, Yoshinori Fujimura, and Hirofumi Tachibana

Molecular Nutrition & Food Research   64   2020.4

Cancer cell selective probe by mimicking EGCG Reviewed International journal

Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, and Hirofumi Tachibana

Biochem. Biophys. Res. Commun.   525   974 - 981   2020.2

Epigallocatechin-3-O-gallate induces acid sphingomyelinase activation through activation of phospholipase C Reviewed International journal

Jaehoon Bae, Motofumi Kumazoe, Chieri Takeuchi, Shiori Hidaka, Yoshinori Fujimura, and Hirofumi Tachibana

Biochem. Biophys. Res. Commun.   520   186 - 191   2019.4

Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro Reviewed International journal

Akira Iwamoto, Yuichi Inoue, Hirofumi Tachibana, Hiroharu Kawahara

Cytotechnology   71 ( 2 )   573 - 581   2019.4

Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity Reviewed International journal

Jaehoon Bae, Motofumi Kumazoe, Yoshinori Fujimura, and Hirofumi Tachibana

J. Nutr. Biochem.   64   152 - 161   2019.2

Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8 Reviewed International journal

Masafumi Wasai, Haruna Nonaka, Motoki Murata, Ryo Kitamura, Yuka Sato, and Hirofumi Tachibana

Biosci. Biotechnol. Biochem.   83   339 - 347   2018.10

Postprandial glycaemia-lowering effect of a green tea cultivar Sunrouge and cultivar-specific metabolic profiling for determining bioactivity-related ingredients Reviewed International journal

Masafumi Wasai, Yoshinori Fujimura, Haruna Nonaka, Ryo Kitamura, Motoki Murata, and Hirofumi Tachibana

Sci. Rep.   8   16041   2018.10

Inhibition of amyloid fibril formation in the variable domain of <lambda>6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate Reviewed International journal

Yoshito Abe, Naoki Odawara, Nantanat Aeimhirunkailas, Hinako Shibata, Naoki Fujisaki, Hirofumi Tachibana, Tadashi Ueda

Biochim Biophys Acta Gen. Subj.   1862   2570 - 2578   2018.8

O-Methylated catechins from "Benifuuki" green tea reduce serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: a double-blind placebo-controlled randomized trial Reviewed International journal

Masahiro Miyawaki, Hiroyuki Sano, Hisashi Imbe, Reiko Fujisawa, Keiji Tanimoto, Jungo Terasaki, Mari Maeda-Yamamoto, Hirofumi Tachibana, Akihisa Imagawa, Toshiaki Hanafusa

Nutrients   10   924   2018.7

Saturated fatty acid inhibits anti-obesity effect of green tea. Reviewed International journal

Shuya Yamashita, Asami Hirashima, I-Chian Lin, Jaehoon Bae, Kanami Nakahara, Motoki Murata, Shuhei Yamada, Motofumi Kumazoe, Ren Yoshitomi, Mai Kadomatsu, Yuka Sato, Ayaka Nezu, Ai Hikita, Konatsu Fujino, Kyosuke Murata, Mari Maeda-Yamamoto and Hirofumi Tachibana

Sci. Rep.   8   10023   2018.7

A randomized, placebo-controlled study on the safety and efficacy of daily ingestion of green tea (Camellia sinensis L.) cv. “Yabukita” and “Sunrouge” on eyestrain and blood pressure in healthy adults Reviewed International journal

Mari Maeda-Yamamoto , Mie Nishimura, Nobuyoshi Kitaichi, Atsushi Nesumi, Manami Monobe, Sachiko Nomura, Yukihiko Horie, Hirofumi Tachibana, Jun Nishihira

Nutrients, 2018, 10, 569;   2018.2

A harmonized immunoassay with liquid chromatograph-mass spectrometry analysis in egg allergen determination. Reviewed International journal

Masaomi Nimata, Hideki Okada, Kei Kurihara, Tsukasa Sugimoto, Tsutomu Honjoh, Kazuhiko Kuroda, Takeo Yano, Hirofumi Tachibana, and Masahiro Shoji

Anal. Bioanal. Chem., 410, 325-335 (2018)   2018.2

Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: the Kakegawa cohort study. Reviewed International journal

Hisashi Ohseto, Mami Ishikuro,Masahiro Kikuya,Taku Obara, Yuko Igarashi, Satomi Takahashi, Michiko Shigihara,Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, and Shinichi Kuriyama

J. Psychosomatic Res., 107, 20-25 (2018)   2018.2

Green tea polyphenol EGCG upregulates Tollip expression by suppressing Elf-1 expression. Reviewed International journal

Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri,　Kenji Kangawa, and Hirofumi Tachibana

J. Immunol., 199, 3261-3269 (2017)   2017.7

Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production Reviewed International journal

Won, YS., Kumazoe, M., Takamatsu, K., Shinoda, Y., Sonoda, S., Okada, K., Okamoto, T., Tachibana, H.

J. Nat. Med., 71, 68-75(2017)   2017.7

Effect of Sunrouge on the postprandial blood glucose level. Reviewed International journal

Masafumi Wasai, Nobuaki Urata, Yuji Fujii, Akiyoshi Kawaoka, Hirofumi Tachibana, Suguru Fujiwara, Katsuhisa Sakano, Mayumi Hayashi, Shukuko Ebihara

Jpn. Pharmacol. Ther., 45, 105-111(2017)   2017.7

Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells. Reviewed International journal

Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana

Sci. Rep., 7, 6665 (2017)   2017.7

The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. Reviewed International journal

Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Mai Kadomatsu, Takashi Nojiri, Hiroaki Onda, Jaehoon, B., Yuhui Huang, Takamatsu, K., Shuya Yamashita, Kenji Kangawa, Hirofumi Tachibana

J. Biol. Chem., doi:10.1074/jbc.M116.772111   2017.5

A Chemometrics-driven Strategy for the Bioactivity Evaluation of Complex Multicomponent Systems and the Effective Selection of Bioactivity-predictive Chemical Combinations. Reviewed International journal

Yoshinori Fujimura, Chihiro Kawano, Ayaka Maeda-Murayama, Asako Nakamura, Kanako Takamatsu, Akiko Koike-Miki, Daichi Yukihira, Eisuke Hayakawa, Takanori Ishii, Hirofumi Tachibana, Hiroyuki Wariishi, Daisuke Miura

Sci. Rep., 7, 2257 (2017)   2017.4

FOXO3 is essential for CD44 expression in pancreatic cancer cells. Reviewed International journal

Motofumi Kumazoe, Takai, M., Jaehoon, B., Yuhui Huang, Takamatsu, K., Won, YS., Hiroi,S., Shuya Yamashita, Shuhei Yamada, Murata, M., Tsukamoto, S., Hirofumi Tachibana

Oncogene, doi:10.1038/onc.2016.426   2017.3

PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma. Reviewed International journal

Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Kanako Takamatsu, Yuhui Huang, Jaehoon, B., Shuya Yamashita, Shuhei Yamada, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana

Sci. Rep., 7, 1917 (2017)   2017.3

Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Upregulation of E3 Ubiquitin-protein Ligase RNF216. Reviewed International journal

Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Takamatsu, K., Yuhui Huang, Jaehoon, B., Shuya Yamashita, Murata, M., Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana

J. Biol. Chem., 292, 4077-4088 (2017)   2017.3

Oligomer formation of a tea polyphenol, EGCG on its sensing molecule the 67-kDa laminin receptor. Reviewed International journal

Yuhui Huang, Mami Sumida,, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Fujimura Y, Hirofumi Tachibana

Chemical Communication, 53, 1941-1944 (2017) .   34   2017.2

SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells Reviewed International journal

Tsukamoto, S., Kumazoe, M., Huang, Y., Yamada, S., Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana

Br. J. Haematol., in press   2016.8

The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Accompanied by Suppression of Cholester Reviewed International journal

Yamashita, M., Kumazoe, K., Nakamura, N., Won, YS., Bae, J., Yamashita, S., Hirofumi Tachibana

J.Nutr.Sci.Vit., 62, 249-256 (2016)   2016.8

6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of zido-containing chemical probes. Reviewed International journal

Hamagami, H., Kumazoe, K., Yamaguchi,Y., Fuse,S., Hirofumi Tachibana, Tanaka, H.

Chemistry - Eur. J., 22, 12884-12890 (2016).   2016.8

The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR. Reviewed International journal

Shiraishi, N., Kumazoe, K., Fuse,S., Hirofumi Tachibana, Tanaka, H.

Chemistry - Eur. J.,22, 13050-13053 (2016).   2016.8

Green Tea Catechin Metabolites Derived from Intestinal Bacteria Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activity Reviewed International journal

Kim, YH., Won, Y., Xue, Y., Kumazoe, K., Yamashita, S., Hara, A., Takagaki, A., Goto,K., Nanjo,F., Hirofumi Tachibana

J. Agri. Food Chem., 64, 3591-3597 (2016)   34   1162 - 1168   2016.7

Delphinidin prevents muscle atrophy and upregulates miR-23a expression. Reviewed International journal

Motoki Murata, Haruna Nonaka, Satomi Komatsu, Kumazoe, K., Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Yamashita, S., Hirofumi Tachibana

J. Agri. Food Chem., 65, 45-50 (2017).   34   1162 - 1168   2016.7

"Benifuuki" Green Tea, Containing O-methylated EGCG, Reduces Serum Low-Density Lipoprotein Cholesterol and Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind, Placebo-Controlled Randomized Trial Reviewed International journal

Imbe, H., Sano, H., Miyawaki, M., Fujisawa, R., Miyasato, M., Nakatsuji, M., Haseda, F., Tanimoto, K., Hanafusa, T., Terasaki, J., Hirofumi Tachibana, Maeda-Yamamoto, M.

J. Fuct. Foods　25,　25-37 (2016)   2016.7

Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice. Reviewed International journal

Lin, IC., Yamashita, S., Murata, M., Kumazoe, M., Hirofumi Tachibana

J. Nutr. Biochem., 32, 101-106 (2016)   6   19225   2016.5

Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-gallate: Potential Mechanism for the Formation of Innate Antigens by Antioxidants Reviewed

Hatasa, Y, Chikazawa, M., Furuhashi, M., Nakashima, F., Shibata, T., Kondo, T., Akagawa, M., Tanaka, H., Hirofumi Tachibana, Uchida, K.

PLoS ONE, 11(4), e0153002 (2016)   2016.5

Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells Reviewed International journal

Yamada, S., Tsukamoto1, S., Huang, Y., Makio, A, Kumazoe, K., Yamashita, S., Hirofumi Tachibana

Scientific Reports   6   19225   2016.1

γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. Reviewed International journal

Yamada, S., Baba, K, Makio, A, Kumazoe, K., Huang, Y., Yamashita, S., Lin, IC., Bae, J., Murata, M., Yamada, S., Hirofumi Tachibana

Biochem. Biophys. Res. Commun., 473, 801-807（2016）.   6   19225   2016.1

Sphingosine kinase-1 protects B-cell neoplasm and myeloid leukemia from apoptosis driven by cancer specific inhibition of RTKs. Reviewed International journal

Tsukamoto, S., Huang, Y., Kumazoe, M., Kim, YH., Yamashita, S., Murata, M., Suzuki, T., Ueda, N., Yoshinori Fujimura, Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana

Mol. Cancer Theraputic.   2015.8

Metabolic profiling-based data-mining for an effective chemical combination to induce apoptosis of cancer cells. Reviewed International journal

Kumazoe, M., Yoshinori Fujimura, Shiori HIdaka, Kim, YH., Tsukamoto, S., Kanako Murayama, Mika Takai, Huang, Y., Yamashita, S., Daisuke Miura, Mari Maeda-Yamamoto, Hirofumi Tachibana

Sci. Rep.   5   9474   2015.3

Pentagalloylglucose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mouse Reviewed International journal

Kim, YH., Yamashita, S., Kumazoe, M., Huang, Y., Shiori HIdaka, Nakahara, K., Won, YS., Murata, M., Lin, I., Koji Yamada, Hirofumi Tachibana

Int. Immunopharmacol.   26   30 - 36   2015.3

67kDa-laminin receptor-dependent PP2A activation elicits melanoma-specific antitumor activity overcoming drug resistance. Reviewed International journal

Tsukamoto, S., Huang, Y., Umeda , D., Yamashita, S., Kumazoe, M., Murata, M., Kim, YH., Koji Yamada, Hirofumi Tachibana

J. Biol. Chem.   2014.12

IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation Reviewed International journal

Kim, Y.H., Shuya Yamashita, Kumazoe, M., Yuhui Huang, Motoki Murata, Won, YS., Yamada, K., Ninomiya,Y., Tachibana H.

Biochem. Biophys. Res. Commun.   450   824 - 830   2014.9

In situ label-free visualization of orally dosed strictinin within mouse kidney by MALDI-MS imaging. Reviewed International journal

Kim, YH., Yoshinori Fujimura, Masako Sasaki, Yang, X., Daichi Yukihira, Daisuke Miura, Unno, Y., Ogata, K., Hiroyuki Wariishi, Nakajima, H., Yamashita, S., Koji Yamada, Hirofumi Tachibana, Kanami Nakahara, Murata, M., Lin,I.

J. Agri. Food Chem.   62   9279 - 9285   2014.9

Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells. Reviewed International journal

Kumazoe, M., Tsukamoto, S., Lesnick, C, Kay, N. E., Koji Yamada, Shanafelt T. D., Hirofumi Tachibana

Br. J. Haematol.   2014.9

Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder. Reviewed International journal

Takashi Suzuki, Shuya Yamashita, Yukari Tsurudome, Motofumi Kumazoe, Huang, Y., Kanami Nakahara, Yuki Shinoda, Wataru Yamaguchi, Mari Maeda-Yamamoto, Koji Yamada, Hirofumi Tachibana

Scientific. Reports   3   2749   2013.9

In situ label-free imaging for visualizing biotransformation of bioactive polyphenol. Reviewed International journal

Kim, YH., Yoshinori Fujimura, Nagao, T, Takatoki Hagihara, Masako Sasaki, Daichi Yukihira, Daisuke Miura, HIroshi Tanaka, Saito, D., Hiroyuki Wariishi, Koji Yamada, Hirofumi Tachibana

Scientific Reports   3   2013.9

1,2,3,4,6-penta-O-galloyl-β-D-glucose from tannic acid inhibits antigen-specific IgE production by inhibiting  germline transcription induced by STAT6 activation. Reviewed International journal

Kim, Y.H., Nakayama, K., Yoshimoto, M., Tanino, S., Koji Yamada, Hirofumi Tachibana

FEBS Open Bio   2013.8

Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis. Reviewed International journal

Kumazoe, M., Kim, Y-H., Tsukamoto, S., Huang, Y., Nakahara, K., Bae, JH., Takai, M., Suemasu, Y., Motoki Murata, Sugihara, K., 山下 修矢, Koji Yamada, Hirofumi Tachibana

FEBS Letter   2013.8

67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. Reviewed International journal

Kumazoe, M., Sugihara, K., Tsukamoto, S., Huang, Y., Tsurudome, Y., Suzuki, T., Suemasu, Y., Yamashita, S., Kim, Y-H., Koji Yamada, Hirofumi Tachibana

J.Clin.Invest.   123   787 - 799   2013.2

Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG. Reviewed International journal

Tsukamoto, S., Yamashita, S., Kim, Y.H., Kumazoe, M., Huang, Y., Koji Yamada, Hirofumi Tachibana

FEBS Lett.   586   3441 - 3447   2012.8

Isoflavones suppress the expression of the FcεRI high-affinity IgE receptor independently of estrogen receptor. Reviewed International journal

Yamashita, S., Yano, S., Tsukamoto, S., Kumazoe, M., Kim, Y-H., Koji Yamada, Hirofumi Tachibana

J. Agric. Food Chem.   60 ( 8 )   8379 - 8385   2012.8

Green Tea Polyphenol EGCG Sensing Motif on the 67-kDa Laminin Receptor. Reviewed International journal

Fujimura, Y., Sumida, M. Sugihara, K., Tsukamoto, S., Yamada, K., and Tachibana, H.

PLoS ONE, e37942, 7(5) (2012).   2012.5

Green tea polyphenol EGCG induces lipid raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through 67-kDa laminin receptor in multiple myeloma cells. Reviewed International journal

Tsukamoto, S., Hirotsu, K., Kumazoe, M., Goto, Y., Sugihara, K., Suda, T., Tsurudome, Y., Suzuki, T., Yamashita, S., Kim, Y., Huang, Y., Yamada, K., and Tachibana, H.

Biochem. J.   443   2012.2

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars Reviewed International journal

Fujimura, Y., Kurihara, K., Ida, M., Kosaka, R., Miura, D., Wariishi, H., Maeda-Yamamoto, M., Nesumi, A., Saito, T., Kanda, T., Yamada, K., and Tachibana, H.

PLoS ONE   585   2011.5

Green tea polyphenol epigallocatechin-3-gallate inhibites TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor. Reviewed International journal

Byun, E.-H., Omura, T., Yamada, K., and Tachibana, H.

FEBS Lett.   585   2011.3

Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa Laminin Receptor. Reviewed International journal

Lee JH., Kishikawa M., Kumazoe M., Yamada K., and Tachibana H.

PLoS ONE   5 ( 6 )   2010.6

TLR 4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. Reviewed International journal

Byun E-H., Fujimura Y., Yamada K., and Tachibana H.

J. Immunol.   185   2010.6

Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. Reviewed International journal

Yamashita, S., Yamashita, T., Yamada, K., and Tachibana, H.

FEBS Lett.   587   2010.3

The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins Reviewed International journal

Fujimura, Y., Umeda, D., Yamada, K., and Tachibana, H.

Arch. Biochem. Biophys.   2008.7

Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells Reviewed International journal

Umeda, D., Yano, S., Yamada, K., and Tachibana, H.

Biochem. Biophys. Res. Commun.   2008.6

Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor Reviewed International journal

Umeda, D., Yano, S., Yamada, K., and Tachibana, H.

J. Biol. Chem.   283   2008.2

The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG Reviewed International journal

Fujimura, Y., Umeda, D., Yano, S., Maeda-Yamamoto, M., Yamada, K., and Tachibana, H.

Biochem. Biophys. Res. Commun.   364   2007.10

Dietary flavones suppress IgE and Th2 cytokines in OVA-immunized BALB/c mice Reviewed International journal

Yano, S., Umeda, D., Yamashita, T., Ninomiya, Y., Sumida,M., Fujimura, Y., Yamada, K., and Tachibana, H.

Eur J. Nutr.   46 ( 5 )   2007.5

The aggregated ursolic acid, a natural triterpenoid, induces interleukin-1β release in murine peritoneal macrophages: A role of CD36 Reviewed International journal

Ikeda, Y., Murakami, M., Fujimura, Y., Tachibana, H., Yamada, K., Hirano, K., Masuda, D., Ohigashi, H.

J. Immunol.   178   2007.4

Relationship between biological activities of methylated derivatives of EGCG and their cell surface binding activities Reviewed International journal

Yano, S., Fujimura, Y., Umeda, D., Miyase, T., Yamada, K, and Tachibana,H.

J. Agric. Food Chem.   55 ( 17 )   2007.3

The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate Reviewed International journal

Fujimura,Y., Yamada, K., and Tachibana, H.

Biochem. Biophys. Res. Commun.   2006.11

A lipid raft-associated 67 kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcεRI expression Invited Reviewed International journal

Fujimura,Y., Yamada, K., and Tachibana, H.

Biochem. Biophys. Res. Commun.   336 ( 2 )   674 - 681   2005.8

Isoflavone genestein and daizein up-regulate LPS-inducible oxide synthase activity through estrogen receptor pathway in RAW264.7 cells Reviewed International journal

Nakaya, M., Tachibana, H., and Yamada, K.

Biochem. Pharmacol.   71 ( 1-2 )   108 - 114   2005.6

Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67kDa laminin receptor Reviewed International journal

Umeda, D., Tachibana, H, and Yamada, K.

Biochem. Biophys. Res. Commun.   333 ( 2 )   628 - 635   2005.6

Trans10,cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilizationinrat hepatoma cells Reviewed International journal

Yamasaki, M, Miyamoto, Y, Chujo, H, Nishiyama, K, Tachibana,H, Yamada, K

Biochim Biophys Acta   1735 ( 3 )   176 - 184   2005.2

A receptor for green tea polyphenol EGCG Reviewed International journal

Tachibana, H., Koga, K., Fujimura, Y., and Yamada, K.

Nature Struc. Mol. Biol.   11 ( 4 )   380 - 381   2004.4

O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells Reviewed International journal

Maeda-Yamamoto, M., Inagaki, N., Kitaura, J., Chikumoto, T., Kawahara, H., Kawakami,Y., Sano, M., Miyase, T., Tachibana, H., Nagai, H., and Kawakami, T.

J. Immunol.,   172 ( 7 )   4486 - 4492   2004.4

Lipid raft-associated catechin suppresses the FceRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2 Reviewed International journal

Fujimura, Y., Tachibana, H., and Yamada, K.

FEBS Lett.   556 ( 1-3 )   204 - 210   2004.1

Modulation of body fat and serum leptin levels by dietary conjugated 　linoleic acid in Sprague-Dawley rats fed various fat level diets. Reviewed International journal

Yamasaki, M., Ikeda, A., Oji, M., Tanaka, Y., Hirao, A., Kasai, M., Iwata, T., Tachibana, H., and Yamada, K.

Nutrition   19 ( 1 )   30 - 35   2003.1

Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. Reviewed International journal

Yamasaki, M., Chujo, H., Hirao, A., Koyanagi, N., Okamoto, T., Tojo, N., Oishi, A., Iwata, T., Yamauchi-Sato, Y., Yamamoto, T., Tsutsumi , K., Tachibana, H., and Yamada, K.

J. Nutr.   133 ( 3 )   784 - 788   2003.1

Induction of light chain replacement in human plasma cells by caffeine independent from enhancement of RAG proteins expression and germ-line transcription. Reviewed International journal

Tachibana, H., Haruta, H., Ueda, K., Chiwata, T. and Yamada, K.

J. Biol. Chem.   275 ( 8 )   5927 - 5933   2000.8

Light Chain Shifting: Identification of a human plasma cell line actively undergoing light chain replacement. Reviewed International journal

Tachibana, H., Haruta, H. and Yamada, K.

Blood   93 ( 1 )   198 - 207   1999.4

Bioactivity Evaluation and Phytochemical Characterization of <i>Euonymus alatus</i> (Thunb.) Siebold Leaf Extract

Yoon, WJ; Min, HJ; Cho, HD; Kim, HG; Park, WL; Kim, D; Tachibana, H; Seo, KI

BIOMEDICINES   12 ( 12 )   2024.12   （ ISSN:2227-9059 eISSN:2227-9059 ）

Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes

Murata, M; Takahashi, R; Marugame, Y; Fujimura, Y; Tachibana, H

BIOCHEMISTRY AND BIOPHYSICS REPORTS   40   101884   2024.12   （ ISSN:2405-5808 ）

MicroRNA mediates the effects of food factors

Kumazoe, M; Tachibana, H

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   89 ( 2 )   174 - 178   2024.11   （ ISSN:0916-8451 eISSN:1347-6947 ）

Future outlook for food function research.

Tachibana H

Bioscience, biotechnology, and biochemistry   89 ( 2 )   201 - 204   2024.9   （ ISSN:0916-8451 eISSN:1347-6947 ）

Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies

Lu, Z; Verginadis, I; Kumazoe, M; Castillo, GM; Yao, Y; Guerra, RE; Bicher, S; You, MH; Mcclung, G; Qiu, R; Xiao, ZB; Miao, Z; George, SS; Beiting, DP; Nojiri, T; Tanaka, Y; Fujimura, Y; Onda, H; Hatakeyama, Y; Nishimoto-Ashfield, A; Bykova, K; Guo, W; Fan, Y; Buynov, NM; Diehl, JA; Stanger, BZ; Tachibana, H; Gade, TP; Puré, E; Koumenis, C; Bolotin, EM; Fuchs, SY

SCIENCE TRANSLATIONAL MEDICINE   16 ( 761 )   eadn0904   2024.8   （ ISSN:1946-6234 eISSN:1946-6242 ）

Cationic lipids modification of natriuretic peptide to increase potency and in vivo stability

Castillo, G; Yao, Y; Tachibana, H; Kumazoe, M; Tanaka, Y; Nojiri, T; Bolotin, E; Nishimoto-Ashfield, A; Geurra, R

JOURNAL OF PEPTIDE SCIENCE   30   2024.8   （ ISSN:1075-2617 eISSN:1099-1387 ）

フスチンはcAMP/PKA依存性機序を介してメラノーマ細胞増殖を抑制する(Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism)

Kumazoe Motofumi, Fujimura Yoshinori, Shimada Yu, Onda Hiroaki, Hatakeyama Yui, Tachibana Hirofumi

Bioscience, Biotechnology, and Biochemistry   88 ( 8 )   900 - 907   2024.8   （ ISSN:0916-8451 ）

Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism

Kumazoe, M; Fujimura, Y; Shimada, Y; Onda, H; Hatakeyama, Y; Tachibana, H

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   88 ( 8 )   900 - 907   2024.6   （ ISSN:0916-8451 eISSN:1347-6947 ）

Identification rate of <i>Legionella</i> species in non-purulent sputum culture is comparable to that in purulent sputum culture in <i>Legionella</i> pneumonia

Ito, A; Ishida, T; Tachibana, H; Nakanishi, Y; Kawataki, M; Yamazaki, A; Washio, Y

JOURNAL OF CLINICAL MICROBIOLOGY   62 ( 4 )   e0166523   2024.4   （ ISSN:0095-1137 eISSN:1098-660X ）

miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11

Kumazoe, M; Miyamoto, E; Oka, C; Kondo, M; Yoshitomi, R; Onda, H; Shimada, Y; Fujimura, Y; Tachibana, H

ISCIENCE   27 ( 1 )   108730   2024.1   （ eISSN:2589-0042 ）

Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway(タイトル和訳中)

Shimada Yu, Kumazoe Motofumi, Otsuka Yushi, Tetsuzen Rin, Fujimura Yoshinori, Tachibana Hirofumi

Journal of Natural Medicines   78 ( 1 )   208 - 215   2024.1   （ ISSN:1340-3443 ）

Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract Reviewed

Won-Joo Yoon, Hye-Ji Min , Hyun-Dong Cho, Hwi-Gon Kim, Wool-Lim Park, Du-Hyun Kim, Hirofumi Tachibana and Kwon-Il Seo

Biomedicines   2024

Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes Reviewed

Motoki Murata, Rina Takahashi, Yuki Marugame, Yoshinori Fujimura, and Hirofumi Tachibana

Biochemistry and Biophysics Reports   2024

The anti-cancer effect of epigallocatechin-3-O-gallate against multiple myeloma cells is potentiated by 5,7-dimethoxyflavone

Bae, J; Kumazoe, M; Park, SJ; Fujimura, Y; Tachibana, H

FEBS OPEN BIO   13 ( 11 )   2147 - 2156   2023.11   （ ISSN:2211-5463 ）

Limocitrin Suppresses Breast Cancer Through Inducing Apoptotic-Cell Death Signaling and Inhibiting the PI3K/AKT/mTOR/S6K Cell Survival Signaling

Lim, HJ; Bae, J; Bak, SG; Chandimali, N; Park, EH; Park, SI; Tachibana, H; Won, YS; Lee, SJ

JOURNAL OF MEDICINAL FOOD   26 ( 10 )   749 - 759   2023.10   （ ISSN:1096-620X eISSN:1557-7600 ）

67-kDa laminin receptor mediates oolonghomobisflavan B-induced cell growth inhibition in melanoma

Bae, J; Kumazoe, M; Lee, KW; Fujimura, Y; Tachibana, H

PHYTOMEDICINE   118   154970   2023.9   （ ISSN:0944-7113 eISSN:1618-095X ）

Bioactivity of Flavonoids through Regulation of microRNA Expression

MURATA Motoki, TACHIBANA Hirofumi

KAGAKU TO SEIBUTSU   61 ( 8 )   371 - 378   2023.8   （ ISSN:0453073X eISSN:18836852 ）

Anti-inflammatory mechanism of EGCG by suppressing expression of Elf-1

Yamashita, M; Kumazoe, M; Kobarai, H; Nakamura, Y; Fujimura, Y; Tachibana, H

ANNALS OF NUTRITION AND METABOLISM   79   957 - 957   2023.8   （ ISSN:0250-6807 eISSN:1421-9697 ）

Effect of theogallin on cognitive function in mice

Lee, K; Otsuka, Y; Fujimura, Y; Tachibana, H

ANNALS OF NUTRITION AND METABOLISM   79   1054 - 1054   2023.8   （ ISSN:0250-6807 eISSN:1421-9697 ）

67-kDa laminin receptor mediates the beneficial effects of a green tea polyphenol EGCG

Tachibana, H

ANNALS OF NUTRITION AND METABOLISM   79   214 - 214   2023.8   （ ISSN:0250-6807 eISSN:1421-9697 ）

A gold-complex initiated functionalization of biologically active polyphenols applied to a <SUP>18</SUP>F-labeled chemical probe

Liu, ZY; Fukagawa, Y; Yamano, M; Tago, T; Iwai, K; Hirano, K; Kumazoe, M; Tachibana, H; Toyohara, J; Tanaka, H

ORGANIC & BIOMOLECULAR CHEMISTRY   21 ( 29 )   5990 - 5996   2023.7   （ ISSN:1477-0520 eISSN:1477-0539 ）

(-)-Epigallocatechin-3-<i>O</i>-gallate upregulates the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells

Murata, M; Marugame, Y; Morozumi, M; Murata, K; Kumazoe, M; Fujimura, Y; Tachibana, H

BIOMEDICAL REPORTS   18 ( 3 )   19   2023.3   （ ISSN:2049-9434 eISSN:2049-9442 ）

抗アレルギー性O-メチル化カテキンに柑橘類フラバノンのヘスペレチンを組み合わせた生物活性促進戦略(Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin)

Fujimura Yoshinori, Yoshimoto Takanori, Fujino Konatsu, Nezu Ayaka, Marugame Yuki, Bae Jaehoon, Kumazoe Motofumi, Tachibana Hirofumi

Journal of Natural Medicines   77 ( 2 )   363 - 369   2023.3   （ ISSN:1340-3443 ）

Bioactivity-boosting strategy based on combination of anti-allergic <i>O</i>-methylated catechin with a <i>Citrus</i> flavanone, hesperetin

Fujimura, Y; Yoshimoto, T; Fujino, K; Nezu, A; Marugame, Y; Bae, J; Kumazoe, M; Tachibana, H

JOURNAL OF NATURAL MEDICINES   77 ( 2 )   363 - 369   2023.3   （ ISSN:1340-3443 eISSN:1861-0293 ）

ケルセチンはヒト子宮頸癌において腫瘍抑制性microRNAの発現を亢進する(Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer)

Murata Motoki, Komatsu Satomi, Miyamoto Emi, Oka Chihiro, Lin Ichian, Kumazoe Motofumi, Yamashita Shuya, Fujimura Yoshinori, Tachibana Hirofumi

Bioscience of Microbiota, Food and Health   42 ( 1 )   87 - 93   2023.1   （ ISSN:2186-6953 ）

Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer

MURATA Motoki, KOMATSU Satomi, MIYAMOTO Emi, OKA Chihiro, LIN Ichian, KUMAZOE Motofumi, YAMASHITA Shuya, FUJIMURA Yoshinori, TACHIBANA Hirofumi

Bioscience of Microbiota, Food and Health   42 ( 1 )   87 - 93   2023   （ ISSN:2186-6953 eISSN:21863342 ）

Limocitrin Suppresses Breast Cancer Through Inducing Apoptotic-Cell Death Signaling and Inhibiting the PI3K/AKT/mTOR/S6K Cell Survival Signaling Reviewed International coauthorship

Hyung-Jin Lim, Jaehoon Bae, Seon-Gyeong Bak, Nisansala Chandimali, Eun Hyun Park, Sang-Ik Park, Hirofumi Tachibana, Yeong-Seon Won, and Seung-Jae Lee

J. Medicinal Food   2023

A gold-complex initiated functionalization of biologically active polyphenols applied to 18F-labeled chemical probe Reviewed

Ziyun Liu,Yuki Fukagawa,Masaharu Yamano,Tetsuro Tago,Kumiko Iwai,Keiichi Hirano,Motofumi Kumazoe, Hirofumi Tachibana,Jun Toyohara,and Hiroshi Tanaka

Organic & Biomolecular Chemistry   2023

Multi-Institutional Study of End-to-End Dose Delivery Quality Assurance Testing for Image-Guided Brachytherapy Using a Gel Dosimeter

Tachibana, H; Watanabe, Y; Kurokawa, S; Maeyama, T; Hiroki, T; Ikoma, H; Hirashima, H; Kojima, H; Shiinoki, T; Tanimoto, Y; Shimizu, H; Shishido, H; Oka, Y; Hirose, TA; Kinjo, M; Morozumi, T; Kurooka, M; Suzuki, H; Saito, T; Fujita, K; Shirata, R; Inada, R; Yada, R; Yamashita, M; Kondo, K; Hanada, T; Takenaka, T; Usui, K; Okamoto, H; Asakura, H; Notake, R; Kojima, T; Kumazaki, Y; Hatanaka, S; Kikumura, R; Nakajima, M; Nakada, R; Suzuki, R; Mizuno, H; Kawamura, S; Nakamura, M; Akimoto, T

BRACHYTHERAPY   21 ( 6 )   956 - 967   2022.11   （ ISSN:1538-4721 eISSN:1873-1449 ）

Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor

Shimada, Y; Sato, Y; Kumazoe, M; Kitamura, R; Fujimura, Y; Tachibana, H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   616   33 - 40   2022.8   （ ISSN:0006-291X eISSN:1090-2104 ）

67-kDa Laminin Receptor-Mediated Cellular Sensing System of Green Tea Polyphenol EGCG and Functional Food Pairing

Fujimura, Y; Kumazoe, M; Tachibana, H

MOLECULES   27 ( 16 )   2022.8   （ eISSN:1420-3049 ）

ゴマリグナンはグルタチオンS-トランスフェラーゼ発現を亢進しmicroRNA-669c-3pを抑制する(Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p)

Marugame Yuki, Takeshita Natsuko, Yamada Shuhei, Yoshitomi Ren, Kumazoe Motofumi, Fujimura Yoshinori, Tachibana Hirofumi

Bioscience of Microbiota, Food and Health   41 ( 2 )   66 - 72   2022.4   （ ISSN:2186-6953 ）

Fustin, a Flavanonol, Synergically Potentiates the Anticancer Effect of Green Tea Catechin Epigallocatechin-3-O-Gallate with Activation of the eNOS/cGMP Axis

Kumazoe, M; Fujimura, Y; Yoshitomi, R; Shimada, Y; Tachibana, H

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   70 ( 11 )   3458 - 3466   2022.3   （ ISSN:0021-8561 eISSN:1520-5118 ）

Randomized controlled trial of the effects of consumption of "Yabukita" or "Benifuuki" encapsulated tea-powder on LDL cholesterol level and body weight. Reviewed International journal

Yuko Igarashi, Taku Obara, Mami Ishikuro, Michiko Shigihara, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Youichi Samejima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Food & Nutrition Research, 10.1080/16546628.2017.1334484.   2017.6

Effect of Sunrouge on the postprandial blood glucose level Reviewed International journal

Masafumi Wasai, Nobuaki Urata, Yuji Fujii, Akiyoshi Kawaoka, Hirofumi Tachibana, Suguru Fujiwara, Katsuhisa Sakano, Mayumi Hayashi, Shukuko Ebihara

Jpn. Pharmacol. Ther., 45, 105-111 (2017)   2017.3

Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression Reviewed International journal

Murata, M., Kosaka, R., Kurihara, K., Yamashita, S., Hirofumi Tachibana

Biosci. Biotechnol. Biochem., 80 (8), 1636-1640 (2016)   2016.5

ザクロ酢のヒスタミン放出抑制活性におけるポリフェノール化合物の寄与 Reviewed

宮崎義之, 倉田有希江, 古賀裕章, 山口智, 山田耕路, Hirofumi Tachibana

日本食品科学工学会誌,63(2), 63-69 (2016).   2016.2

Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells. Reviewed

Huang, Y., Kumazoe, K., Bae, J., Yamada, S., Takai, M., Hidaka, S., Yamashita, S., Kim, YH., Won, Y., Murata, M., Tsukamoto1, S., Hirofumi Tachibana

Oncology Rep.   34   1162 - 1168   2015.7

ブロッコリーのビタミンC、S−メチルメチオニン、ポリフェノール含有量の部位別解析と細胞機能への影響 Reviewed

上田京子, 塚谷忠之, 村山加奈子, 倉田有希江, 竹田絵理, 大塚崇文, 高井美佳, 宮崎義之, Hirofumi Tachibana, 山田耕路

日本食品科学工学会誌   62 ( 5 )   242 - 249   2015.5

The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes. Reviewed International journal

Takai, M, Miyazaki, Y., Koji Yamada, Hirofumi Tachibana

Biosci. Biotechnol. Biochem.   78   1743 - 1747   2014.9

A highly sensitive method for quantifying gallocatechin gallate and its epimer using a catechinspecific peptide. Reviewed International journal

Miyamoto, T., Mekada, Y., Kurahachi, M., Umeno, M., Nakayama, M., Shigemune, M., Tsugukuni, T., Tokuda, H., Tachibana, H., and Honjoh, K.

Food Cont., 29, 162-166 (2013).   2013.8

Anti-allergic effects of strawberry extract Reviewed International journal

Akira Iwamoto, Yuichi Inoue, Aiko Inoue, Koji Yamada, Hirofumi Tachibana, Hiroharu Kawahara

J. Funct. Foods   5,   1947 - 1955   2013.7

オキナワモズク由来フコイダンの細胞運動阻害作用 Reviewed

山崎有美, 山崎正夫, 安藤美子, 立花 宏文, 山田 耕路

日本食品科学工学会誌   60 ( 7 )   357 - 361   2013.7

不知火姫菊の花弁および葉抽出液のヒト乳がん細胞MCF-7株に対する増殖抑制作用 Reviewed

村山加奈子, 澤智子, 古賀裕章, 山口智, 熊添基文, 大塚崇文, 宮崎義之, 立花 宏文, 山田 耕路

日本食品科学工学会誌   60 ( 2 )   80 - 86   2013.2

Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Reviewed International journal

Lee J.H., Won, Y.S., Park, K.H., Lee, M.K., Hirofumi Tachibana, Koji Yamada, Seo, K.I.

Apoptosis   17   1275 - 1286   2012.9

Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. ‘Sunrouge’)". Reviewed International journal

Maeda-Yamamoto, M., Saito, T., Nesumi, A., Tokuda, Y., Ema, K., Honma, D., Ogino, A., Monobe, M., Murakami, A., Murakami, A., and Tachibana, H.

J. Sci. Food Agric.92, 2379-2386 (2012).   2012.8

不知火姫菊の花弁および葉抽出液のヒスタミン放出抑制効果 Reviewed

Koji Yamada, Tomoko Sawa, Kanako Murayama, Satoshi Yamaguchi, Hirofumi Tachibana

日本食品科学工学会誌   59 ( 8 )   394 - 400   2012.8

Epicatechin-3-O-(3-O-methyl) gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release. Reviewed International journal

Maeda-Yamamoto, M., Ema, K., Monobe, M., Tokuda, Y., and Tachibana, H.

J. Agric. Food Chem. 60, 2165-2170 (2012)   2012.8

Induction of nitric oxide generation by various cow milk cheeses in RAW264.7 mouse macrophage-like cells. Reviewed International journal

Shin Yasuda, Hirofumi Tachibana, Koji Yamada

Milkscience   61   89 - 94   2012.6

β-Integrin plays an important role in fucoidan-induced apoptosis via caspase-8 activation. Reviewed International journal

Yamasaki, Y., Yamasaki, M., Tachibana, H., and Yamada, Y.

Biosci. Biotechnol. Biochem.,76(6), 1163-1168 (2012).   2012.6

Effect of Highly Lipolyzed Goat Cheese on HL-60 Human Leukemia Cells: Antiproliferative Activity and Induction of Apoptotic DNA Damage. Reviewed International journal

Yasuda, S., Kuwata, H., Kawamoto, K., Shirakawa, J., Atobe, S., Hoshi, Y.,Yamasaki, M., Nishiyama, K., Tachibana,H., Yamada, K., Kobayashi,H., Igoshi,K.

J. Dairy Sci., 95(5), 2248-2260 (2012).   2012.5

Anti-allergic effects of Kakrol (Momordica diocia Roxb.) flesh extract Reviewed International journal

Kim, Y.H., Ida, M., Yamashita, S., Tsukamoto, S., Kumazoe,M., Sumida, M., Mitsuo Kawakami, M., Yamada, K., and Tachibana, H.

Bioscience of Microbiota, Food and Health   31   2012.1

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study. Reviewed International journal

Maeda-Yamamoto, M., Ema, K., Tokuda, Y., Monobe, M., Tachibana, H., Sameshima, Y., and Kuriyama, S.

Cytotechnology   63   2011.8

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study. International journal

Maeda-Yamamoto M, Ema K, Tokuda Y, Monobe M, Tachibana H, Sameshima Y, Kuriyama S.

Cytotechnology   2011.2

Ultra-highly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors. Reviewed International journal

Miura, D., Fujimura, Y., Yamato, M., Hyodo, F., Tachibana, H., and Wariishi, H.

Anal. Chem.   82   2010.12

Solid-phase synthesis of a combinatorial methylated epigallocatechin gallate library and their growth inhibitory effects on melanoma B16 cells. Reviewed International journal

Tanaka H., Yamanouchi M., Miyoshi H., Hirotsu K., Tachibana H., and Takahashi T.

Chem. Asian J.   5 ( 10 )   2010.10

New Insights into Anticancer Effect of Green Tea Polyphenol Epigallocatechin-3-gallate in Hypoxia by Metabolic Profiling. Reviewed International journal

Fujimura, Y., Tsukamoto, S., Irie, M., Miura, D., Wariishi, H., and Tachibana, H.

Free Radic. Biol. Med.   49, Supplement1   2010.10

Analysis of Cisplatin-Induced Nephrotoxicity by In Situ Mass Spectrometry Imaging and Urinary Metabolic Profiling. Reviewed International journal

Miura, D., Fujimura, Y., Hyodo, F., Yasukawa, K., Tachibana, H., and Wariishi, H.

Free Radic. Biol. Med.   49, Supplement1   2010.10

Identification of a Sensing Gene for Antioxidative Flavones. Reviewed International journal

Yamashita, S., Yamada, K. and Tachibana, H.

Free Radic. Biol. Med.   49, Supplement1   2010.10

Comparisons of uptake and cell surface binding among pyridoxal, pyridoxine and pyridoxamine in RAW264.7 cells. Reviewed International journal

Kanouchi H., Shibuya M., Tsukamoto S., Fujimura Y., Tachibana H., Yamada K.,and Oka T.

Nutrition   6 ( 6 )   2010.6

Inhibitory effect on thrombin-induced myosin light chain phosphorylation by an extract of new green tea cultivar in A7r5 rat aortic smooth muscle cells. Reviewed International journal

Kurihara K., Nagatomo S., Maeda-Yamamoto M., Yamada K., and Tachibana H.

Food Sci. Tech. Res.   16 ( 3 )   2010.3

Antihypertensive effect of Benifuuki tea containing O-methylated EGCG Reviewed International journal

Kurita, I., Maeda-Yamamoto, M., Tachibana,. H., and Kamei, M.

J. Agric. Food Chem.   58   2010.2

Highly Sensitive MALDI-Mass Spectrometry for High-throughput Metabolic Profiling Reviewed International journal

Miura, D., Fujimura, Y., Tachibana, H., and Wariishi, H.

Anal. Chem.   82 ( 18 )   2010.1

Specific accumulation of γ and δ-tocotrienols in tumor and their antitumor effect in vivo Reviewed International journal

Hiura, Y., Tachibana, H., Arakawa, R., Aoyama, N., Okabe,M., Sakai, M. and Yamada,K.

J. Nutr. Biochem.   2009.7

Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 Cells Reviewed International journal

Yamasaki-Miyamoto, Y., Yamasaki, M., Tachibana, H., and Yamada, K.

J. Agri. Food Chem.   57 ( 18 )   2009.7

Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids. Reviewed International journal

Lee, J-H., Tachibana, H., Morinaga, Y., Fujimura, Y., and Yamada, K.

Life Sciences   84   2009.7

Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice Reviewed International journal

Yano, S., Umeda, D., Yamashita, S., Yamada, K. and Tachibana, H.

J. Nutr. Biochem.   20   2009.7

Cistanche salsa extract acts similarly to protein-bound polysaccharide-K (PSK) on various types of cell lines. Reviewed International journal

Maruyama, S., Akasaka, T., Yamada, K., and Tachibana, H.

J. Trad. Med.   2009.5

Bioactivity of High-molecular-weight Constituents of Cistanche tubulosa Reviewed International journal

Maruyama, S., Akasaka, T., Yamada, K., and Tachibana, H.

Pharmacologyonline   2009.1

Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway Reviewed International journal

Yamasaki, M, Tachibana, H, Yamada, A, Ochi, Y, Madhyastha, H, Nishiyama ,K, Yamada, K.

In Vitro Cellular & Developmental Biology –Animal   2008.9

The 67 kDa laminin receptor mediates anti-allergic effects of epigallocatechin-3-O-(3-O-methyl) gallate. Reviewed International journal

Fujimura, Y., Umeda, D., Maeda-Yamamoto, M., Yamada,K.and Tachibana, H.

J. Clin. Biochem. Nutr.   2008.9

Relationship between the suppressive effect of methylated derivatives of EGCG on FcεRI Expression and their cell surface binding activities. Reviewed International journal

Yano, S., Fujimura, Y., Umeda, D., Miyase, T., Yamada, K., Tachibana, H.

J. Clin. Biochem. Nutr.   2008.9

Identification of Eukaryotic Translation Elongation Factor 1A as a Downstream Mediator of EGCG Signaling through 67-kDa Laminin Receptor. Reviewed International journal

Umeda, D., Yano, S., Yamada, K., and Tachibana, H.

J. Clin. Biochem. Nutr.   2008.9

H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation Reviewed International journal

Umeda, D., Yamada, K., and Tachibana, H.

Eur. J. Pharm.   2008.9

Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1 Reviewed International journal

Maruyama, S., Yamada, K., and Tachibana, H.

Biomedicine and Pharmacotherapy   63 ( 6 )   2008.6

Immunomodulating activity of Cistanche salsa Reviewed International journal

Maruyama, S., Yamada, K., and Tachibana, H.

J. Trad. Med.   25   2008.6

Cistanche salsa extract induced apoptosis in the human Burkitt’s lymphoma cell clone Namalwa Reviewed International journal

Maruyama, S., Yamada, K., and Tachibana, H.

J. Trad. Med.   25   2008.1

Induction of endoreduplication by a JNK Inhibitor SP600125 in human lung carcinoma A 549 cells Reviewed International journal

Miyamoto-yamasaki, Y. Yamasaki, M. Tachibana, H. Yamada, K.

Cell Biology Int.   31 ( 12 )   2007.12

Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1 Reviewed International journal

Maruyama, S., Yamada, K., and Tachibana, H.

J. Trad. Med.   24   2007.12

Induction of endoreduplication by a JNK Inhibitor SP600125 in human lung carcinoma A 549 cells. Reviewed International journal

Miyamoto-yamasaki, Y. Yamasaki, M. Tachibana, H. Yamada, K.

Cell Biology Int.   2007.11

Study on the molecules involved in anti-allergic effect of soybean components Invited

Tachibana, H., Yano, S., and Yamada, K.

Soy Protein Res.,   2007.6

Effect of royal jerry on bisphenol A-induced proliferation of human breast cancer cells Reviewed International journal

Nakaya, M., Onda, Y., Yukiyoshi, A., Tachibana, H., and Yamada K.

Biosci. Biotechnol. Biochem.   2007.5

スサビノリ水溶性低分子画分のHL-60細胞の増殖に及ぼす影響 Reviewed

柘植圭介、渡部弥生、前田徳秀、阿部真一、鶴橋亨、吉村臣史、吉木政弘、立花宏文、山田耕路

日本食品科学工学会誌   54 ( 2 )   2007.2

Soy-derived immunoglobulin production stimulating factor enhances IgM production of mouse spleen lymphocytes Reviewed International journal

Maeda, N., Yoshimi, K., Tachibana, H., and Yamada, K.

J. Food Sci.   2006.12

Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells Reviewed International journal

Sakai, M., Okabe, M., Tachibana, H., and Yamada, K.

J Nutr Biochem.   2006.10

Effect of royal jerry on bisphenol A-induced proliferation of human breast cancer cells Reviewed International journal

Nakaya, M., Onda, Y., Yukiyoshi, A., Tachibana, H., and Yamada K.

Biosci. Biotechnol. Biochem.   2006.8

Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice Reviewed International journal

Yamasaki M, Kitagawa T, Koyanagi N, Chujo H, Maeda H, Kohno-Murase J, Imamura J, Tachibana H, Yamada K.

Nutrition   2006.6

Effect of estrogens on interferon-γ producing cell population of mouse splenocytes Reviewed International journal

Nakaya, M., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem.   2006.5

Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice Reviewed International journal

Yano, S., Umeda, D., Maeda, N., Fujimura, Y., Yamada, K., and Tachibana,H.

J. Agric. Food Chem   2006.5

Tissue-specific distribution of genistein, daizein and bisphenol A in male Sprague-Dawley rats after intragastric administration Reviewed International journal

Yasuda, S., Wu, P.-O., Okabe, M., Tachibana, H. and Yamada K.

Food Sci. & Tech. Res.   11 ( 2 )   187 - 193   2005.10

IgM production of lymphocytes from C57BL/6N mice was stimulated by estrogen treated splenic adherent cells Reviewed International journal

Nakaya, M., Yamasaki, M., Tachibana, H., and Yamada, K.

Immunol. Lett.   98 ( 2 )   225 - 231   2005.2

Flavones suppress the expression of the high affinity IgE receptor FcεRI in human basophilic KU812 cells Reviewed International journal

Yano, S., Tachibana, H., and Yamada, K.

J. Agric. Food Chem   53 ( 5 )   1812 - 1817   2005.2

Cytotoxity of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol Reviewed International journal

Yamasaki, M., Nishida, E., Nou, S., Tachibana, H., and Yamada, K.

In Vitro Cell. Dev. Biol.   2005.1

Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction. Reviewed International journal

Nakaya, M., Yamasaki, M., Miyazaki, Y., Tachibana, H., Yamada, K.

In Vitro Cell Dev Biol Anim.   39 ( 8-9 )   383 - 387   2003.10

Inhibitory effect of conjugated linoleic acid isomaers on the proliferation of human breast cancer cells. Reviewed International journal

Chujo, H., Yamasaki, M., Koyanagi, N., Iwara, T., Tsutsumi, K., Tachibana, H., and Yamada, K.

Cancer letter   2003.10

Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats. Reviewed International journal

Yamada, K., Tokunaga, Y., Ikeda, A., Ohkura, K., Kaku-Ohkura, S., Mamiya, S., Lim, B.-O., and Tachibana, H.

Biosci. Biotechnol. Biochem.   67 ( 2 )   429 - 433   2003.9

Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid. Reviewed International journal

Yamasaki, M., Chujo, H., Nou, S., Tachibana, H., and Yamada, K.

Cancer lett.   196 ( 2 )   187 - 196   2003.4

大豆サポニンの高親和性IgE受容体発現抑制効果

立花宏文、藤村由紀、矢野和美、山田耕路

大豆たん白質研究   2003.4

Diurnal variation in secretory immunoglobulin A concentration.

Liu, Z., Otonari, M., Naito, S., Yasuda, S., Tanaka, H., Yoshioka, H., Oyabu, M., Tobina, T., Kanda, R., Tanaka, H., Shindo, M., Tachibana, H., and Yamada, K.

J. Fac. Agr. Kyushu Univ.   48 ( 1-2 )   167 - 174   2003.3

Peroxisome proliferator-activated receptor (PPAR) ligands negatively regulate the expression of the high-affinity IgE receptor FceRI in human basophilic KU812 cells. Reviewed International journal

Fujimura, Y., Tachibana, H., and Yamada, K.

Biochem. Biophys. Res. Commun   297 ( 2 )   193 - 201   2002.9

Inhibitory effect of peroxisome proliferator-activated receptor-g ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. Reviewed International journal

Miyazaki, Y., Tachibana, H., and Yamada, K.

Biochem. Biophys. Res. Commun.   295 ( 2 )   547 - 552   2002.8

Antiallergic tea catechin, (-)-Epigallocatechin-3-O-(3-O-methyl) gallate, suppresses FceRI expression in human basophilic KU812 cells. Reviewed International journal

Fujimura, Y., Tachibana, H., Maeda-Yamamoto, M., Miyase, T., Sano, M., and Yamada, K.

J. Agric. Food Chem.   50 ( 20 )   5729 - 5734   2002.7

Relationship between estrogen receptor-binding and estrogenic activites of environmental estrogens and suppression by flavonoids Reviewed International journal

Han, D.-H., Denison M. S., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   66 ( 7 )   1479 - 1487   2002.7

Dietary effect of a-tocopherol and tocotrienols on lipid metaborism and immune function of aged Sprague-Dawley rats. Reviewed International journal

Yamada, K., Okabe, M., Ohkura, K., Oji, M., Nonaka, M., Ikeda, I., and Tachibana, H.

Food Sci. Technol. Res.   8 ( 1 )   59 - 63   2002.1

Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo Reviewed International journal

Yamasaki, M., Ikeda, A., Tanaka, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K.

J. Nutr. Sci. Vitaminol.   48 ( 6 )   505 - 511   2002.1

Potent cytotoxic effect of trans-10, cis-12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells. Reviewed International journal

Yamasaki, M., Chujo, H., Koga, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K.

Cancer Lett.   188 ( 1-2 )   171 - 180   2002.1

Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes Reviewed International journal

Han, D., Denison, M. S., Tachibana, H., and Yamada, K.

Biol. Pharm. Bull.   25 ( 10 )   1263 - 1267   2002.1

Tocotrienol levels in various tissues of Sprague-dawley rats after intragastric administration of tocotrienols. Reviewed International journal

Okabe, M., Oji, M., Ikeda, I., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   66 ( 8 )   1768 - 1771   2002.1

Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone Reviewed International journal

Okamoto, T., Sugahara, T., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   66 ( 6 )   1241 - 1245   2002.1

A tea catechin suppresses the expression of the high affinity IgE receptor FceRI in the human basophilic KU812 cells. Reviewed International journal

Fujimura, Y., Tachibana, H., and Yamada, K.

J. Agric. Food Chem.   49 ( 5 )   2527 - 2531   2001.10

Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes. Reviewed International journal

Takasugi, M., Tamura, Y., Tachibana, H., Sugano, M., and Yamada, K.

Biosci. Biotechnol. Biochem   65 ( 1 )   143 - 149   2001.1

茶の品種、摘採期と製造法による抗アレルギー性カテキンEGCG3モMeの変動. Reviewed

山本（前田）万里、佐野満昭、松田奈帆美、宮瀬敏男、川本恵子、鈴木直子、吉村昌恭、立花宏文、袴田勝弘

日本食品科学工学会誌   2001.1

Recombinant expression of perchloric acid-solble protein reduces cell proliferation. Reviewed International journal

Kanouchi, H., Tachibana, H.,Oka, T., and Yamada, K.

Cell. Mol. Life Sci.   58 ( 9 )   1340 - 1343   2001.1

Identification of an inhibitor for interleukin 4-induced e germline transcription and antigen-specific IgE production in vivo. Reviewed International journal

Tachibana, H., Kubo, T., Miyase, T., Tanino, S., Yoshimoto, M., Sano, M., Yamamoto-Maeda, M., and Yamada, K.

Biochem. Biophys. Res. Commun.   280 ( 1 )   53 - 60   2001.1

Oxidation of cell membrane phospholipids suppresses immunoglobulin production by mouse spleen lymphocytes. Reviewed International journal

Miyazaki, Y., Yamasaki, M., Mishima, H., Mansho, K., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   2001.1

Dietary g-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats Reviewed International journal

Kaku, S., Ohkura, K., Yunoki, S., Nonaka, M., Tachibana, H., Sugano, M., and Yamada, K.

Prostaglandins Leukot Essent Fatty Acids   65 ( 4 )   205 - 210   2001.1

Effect of dietary cabbage fermentation extract and young barley leaf powder on immune function of sprague-Dawley rats. Reviewed International journal

Miyazaki, Y., Tokunaga, Y., Takagaki, K., Tsuzaki, S., Tachibana, H., and Yamada, K.

J. Nutr. Sci. Vitaminol.   47 ( 3 )   253 - 257   2001.1

Effect of dietary conjugated lonoleic acid on the in vivo growth of rat hapatoma dRLh84. Reviewed International journal

Yamasaki, M., Ikeda, A., Hirao, A., Tanaka, Y., Miyazaki, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K.

Nut. Cancer   40 ( 2 )   140 - 148   2001.1

Interaction of flavonoids and environmental estrogens on proliferation of human breast carcinoma MCF-7 cells. Reviewed International journal

Han, D-H., Tachibana, H., and Yamada, K.

In Vitro Cell. Devlop. Biol.   2001.1

Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats Reviewed International journal

Kaku, S., Yunoki, S., Ohkura, K., Sugano, M., Nonaka, M., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   65 ( 2 )   315 - 321   2001.1

Antigen binding of an ovomucoid specific monoclonal antibody is modulated by the carbohydrate chain on the light chain variable region. Reviewed International journal

Fujimura, Y., Tachibana, H., Eto, M., and Yamada, K

Biosci. Biotech. Biochem   64 ( 11 )   2298 - 2305   2000.11

Identification of a methylated epigallocatechin gallate as an inhibitor of degranulation in human basophilic KU812 cells. Reviewed International journal

Tachibana, H., Sunada, Y., Miyase, T., Sano, M., Maeda-Yamamoto, M., and Yamada, K.

Biosci. Biotech. Biochem   2000.11

Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes Reviewed International journal

Yamasaki, M., Kishihara, K., Mansho, K., Ogino, Y., Kasai, M., Tachibana, H., and Yamada, K.

Biosci. Biotechnol. Biochem   64 ( 10 )   2159 - 2164   2000.10

Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats. Reviewed International journal

Yamasaki, M., Mansho, K., Ogino, Y., Kasai, M., Tachibana, H., and Yamada, K.

J. Nutr. Biochem.   11 ( 9 )   467 - 471   2000.1

Basophilic differentiation of the human leukemia cell line KU812 upon treatment with hydrocortisone. Reviewed International journal

Hara, T., Tachibana, H., and Yamada, K.

Cytotechnology.   2000.1

Expression and cellular distribution of perchloric acid-soluble protein is dependent on the cell-proliferating States of NRK-52E cells. Reviewed International journal

Kanouchi, H., Oka, T., Asagi, K., Tachibana, H., and Yamada, K.

Cell. Mol. Life Sci.   57 ( 7 )   1103 - 1108   2000.1

Recent topics in antioxidative factors. International journal

Yamada, K., and Tachibana, H.

BioFactors   13 ( 1-4 )   167 - 172   2000.1

Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats Reviewed International journal

Hung, P., Gu, J-Y., Kaku, S., Yunoki, S., Ohkura, K., Ikeda, I., Tachibana, H., Sugano, M., Yazawa, K., and Yamada, K.

Biosci. Biotechnol. Biochem   2000.1

Effect of dietary conjugated linoleic acid on lipid peroxidation and histological change in rat liver tissues Reviewed International journal

Yamasaki, M., Mansho, K., Mishima, H., Kimura, G., Sasaki, M., Kasai, M., Tachibana, H., and Yamada, K.

J. Agric. Food Chem.   48 ( 12 )   6367 - 6371   2000.1

Structure-activity relationship of immunoregulatory factors in foodstuffs. Reviewed International journal

Yamada, K., Tachibana, H., Matsuo, N., Nishiyama, K., and Sugano, M.

Food Sci. Technol. Res.   1999.1

Serum starvation induced secondary VlJl rearrangement in a human plasma B cell. Reviewed International journal

Haruta, H., Tachibana, H. and Yamada, K.

Mol. Immunol.   36 ( 3 )   177 - 185   1999.1

Concanavalin A stimulation enhanced secondary VlJl rearrangement in some human plasma B cells without up-regulation of recombination activating gene expression and Vl germline transcription. Reviewed International journal

Haruta, T., Tachibana, H. and Yamada, K.

Immunology   97 ( 4 )   549 - 557   1999.1

Dietary effect of guar gum and its partially hydrolyzed product on lipid metabolism and immune function of Sprague-Dawley rats. Reviewed International journal

Yamada K., Tokunaga Y., Ikeda A., Ohkura, K., Mamiya S., Kaku S., Sugano M., and Tachibana H.

Biosci. Biotechnol. Biochem.   63 ( 12 )   2163 - 2167   1999.1

Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. Reviewed International journal

Yamasaki, M., Mansho, K., Mishima, H., Kasai, M., Sugano, M., Tachibana, H., and Yamada K

Biosci. Biotechnol. Biochem.   63 ( 6 )   1104 - 1106   1999.1

Basophilic differentiation of the human leukemia cell line KU812 upon treatment with interleukin-4. Reviewed International journal

Hara, T., Yamada, K. and Tachibana, H.

Biochem. Biophys. Res. Commun.   247 ( 3 )   542 - 548   1998.7

Effect of rosebengal on immunoglobulin production by mouse B lymphoma, WEHI-279 cells. Reviewed International journal

Kuramoto T, Miyazaki Y, Inoue S, Haruta H, Tachibana H, Sugano M and Yamada K

J. Agric. Food Chem.   46 ( 12 )   5368 - 5372   1998.1

食品因子の機能性フードペアリング実験医学増刊号「栄養・代謝物シグナルと食品機能」

立花宏文（Role：Joint author）

羊土社  2022.5 

食品分野におけるメタボリック・プロファイリング活用最前線メタボローム解析を活用したフードデザイン

藤村由紀、＠三浦大典、立花宏文（Role：Joint author）

NTS出版  2021.4 

実験医学増刊　食と健康を結ぶメディカルサイエンス

立花宏文（Role：Joint author）

羊土社  2020.4 

茶ポリフェノールの生理機能と応用展開 緑茶カテキン受容体

立花宏文（Role：Joint author）

シーエムシー出版  2019.4 

茶ポリフェノールの生理機能と応用展開 緑茶成分のメタボリック・プロファイリング解析

藤村由紀、立花宏文（Role：Joint author）

シーエムシー出版  2019.4 

茶ポリフェノールの生理機能と応用展開 緑茶カテキンの抗がん作用メカニズムと活性増強法

熊添基文、立花宏文（Role：Joint author）

シーエムシー出版  2019.4 

茶ポリフェノールの生理機能と応用展開 マイクロRNA発現調節作用

吉冨廉、立花宏文（Role：Joint author）

シーエムシー出版  2019.4 

分子栄養学 4章　遺伝子の発現とその制御

立花宏文（Role：Joint author）

講談社サイエンティフィック  2018.6 

機能性食品開発のための初期評価試験プロトコール集 第12章　抗炎症・抗アレルギー作用

藤村由紀、林宜蒨、吉本孝憲、立花宏文（Role：Joint author）

シーエムシー出版  2018.6 

フラボノイドの抗アレルギー作用 内外美容成分―食べる化粧品の素材研究

山下修矢、立花宏文（Role：Joint author）

シーエムシー出版  2018.6 

高機能茶サンルージュのアルツハイマー病予防効果 アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発

和才昌史、立花宏文（Role：Joint author）

エヌ・ティー・エス出版  2018.4 

食品機能性成分の吸収・代謝・作用機序 緑茶カテキン

立花宏文（Role：Joint author）

シーエムシー出版  2018.4 

Green tea polyphenol EGCG sensing receptor Health Benefits of Green Tea: An Evidence-based Approach

Tachibana, H.（Role：Joint author）

CABI International  2017.10 

非栄養素の分子栄養学 第7章　食品因子センシングの調節による食品因子の機能性増強

山下修矢、立花宏文（Role：Joint author）

建帛社  2017.5 

緑茶カテキンのマイクロRNA発現調節作用、ポリフェノール：機能性成分研究開発の最新動向

Hirofumi Tachibana, 山田脩平（Role：Joint author）

シーエムシー出版  2016.8 

Metabolomics of Green Tea, GENOMICS, PROTEOMICS AND METABOLOMICS IN NUTRACEUTICALS & FUNCTIONAL FOODS (2nd Ed), Ed by Debasis Bagchi, Anand Swaroop, Manashi Bagchi

Fujimura Y, Hirofumi Tachibana（Role：Joint author）

John Wiley & Sons  2015.9 

Scientific Evidence for the Health Benefits of Green Tea

Hirofumi Tachibana（Role：Joint author）

Japan Tea Central Public Interest Incorporated Association  2015.9 

食品因子による栄養機能制御

立花 宏文（Role：Joint author）

建帛社  2015.5 

食物アレルギーの現状とリスク低減化食品素材の開発「マスト細胞・好塩基球を用いた脱顆粒抑制試験」

立花 宏文, Yoshinori Fujimura（Role：Joint author）

シーエムシー出版  2015.1 

ニュートリゲノミクスを基盤としたバイオマーカーの開発-未病診断とテーラーメイド食品開発に向けて-

立花 宏文（Role：Joint author）

シーエムシー出版  2014.9 

新版茶の機能—ヒト試験から分かった新たな役割,緑茶カテキン感知レセプター

立花 宏文（Role：Joint author）

農村漁村文化協会  2013.9 

Tea in Health and Disease Prevention

Maeda-Yamamoto, M., Hirofumi Tachibana, Sameshima, Y., Kuriyama, S.（Role：Joint author）

Taylor & Trancis  2012.12 

Tea in Health and Disease Prevention

Byun, E-H., Hirofumi Tachibana（Role：Joint author）

Taylor & Trancis  2012.12 

機能性食品の作用と安全性百科, 上野川修一、清水俊雄、清水誠、鈴木英毅、武田英二編

立花宏文（Role：Joint author）

丸善出版  2012.7 

Green Tea Polyphenols: Nutraceuticals of Modern Life

立花宏文（Role：Joint author）

Taylor & Trancis  2011.10 

Molecular basis for the anti-cancer activity of EGCG in vivo: Molecular-targeting prevention of cancer by green tea catechin., Green Tea and Health Research

Fujimura, Y., and Tachibana, H.（Role：Joint author）

Nova Publishers  2009.5 

Food Factors for Health Promotion

Tachibana, H.（Role：Joint author）

Forum Nutr.  2009.5 

栄養学研究の最前線

立花宏文（Role：Joint author）

2008.4 

Research Focus on Natural products and the Body's Immune and Inflammatory

Tachibana H（Role：Joint author）

Nova Publisher  2007.12 

抗アレルギー食品開発ハンドブック 抗アレルギー食品開発のターゲット

立花宏文（Role：Joint author）

サイエンスフォーラム  2005.5 

ガン予防食品開発の新展開 緑茶カテキンエピガロカテキンガレート

立花宏文（Role：Joint author）

シーエムシー出版  2005.4 

食品学 嗜好食品

立花宏文（Role：Joint author）

建白社  2005.4 

食品成分のはたらき

立花宏文（Role：Joint author）

朝倉書店  2004.5 

生物機能の進歩I

立花宏文（Role：Joint author）

アイピーシー  2002.5 

茶の機能

立花宏文（Role：Joint author）

学会出版センター  2002.3 

動物細胞工学ハンドブック

立花宏文（Role：Joint author）

朝倉書店  2000.6 

生物機能の新展開-人類の生存をかけて-

立花宏文（Role：Joint author）

日本食品出版  2000.6 

食品・栄養を学ぶ学生にゼロからわかる分子栄養学

叶内 宏明 , 山内 明, 竹中 重雄, 飯塚 勝美, 石原 健吾 , 大石 勝隆, 神戸 大朋, 窪薗 琢郎, 杉元 康志, 瀬川 博子, 立花 宏文, 平坂 勝也, 藤村 由紀, 松村 成暢

建帛社  2024    （ ISBN:9784767907505 ）

FOODStyle21 機能性フードペアリングに基づいた抗肥満食品

立花 宏文

食品化学新聞社  2022 

食品免疫・アレルギーの事典

立花宏文（Role：Joint author）

朝倉書店  2011.4 

バイオチップ実用化ハンドブック

立花宏文（Role：Joint author）

NTS出版  2010.4 

食品機能性の科学

立花宏文（Role：Joint author）

産業技術サービスセンター  2008.5 

免疫と栄養

立花宏文（Role：Joint author）

幸書房  2006.5 

アクティブシニア社会の食品開発指針

立花宏文（Role：Joint author）

サイエンスフォーラム  2006.4 

茶の効能と応用開発

藤村由紀、立花宏文（Role：Joint author）

シーエムシー出版  2006.1 

バイオテクノロジーレビュー’89

立花宏文, 村上浩紀（Role：Joint author）

CMC  1989.5 

食品・栄養を学ぶ学生にゼロからわかる分子栄養学 Reviewed

藤村由紀、立花宏文（Role：Joint author）

緑茶カテキンのケミカルバイオロジー Invited

立花 宏文

日本農芸化学会  2013.3 

質量分析イメージング法による緑茶カテキンおよびその代謝物の生体組織内布情報の非標識可視化

金允喜, 藤村 由紀, 萩原立春, 佐々木雅子, 行平大地, 山口歩, 斉藤和徳, 三浦 大典, 割石 博之, 山田 耕路, 立花 宏文

日本農芸化学会  2013.3 

蛍光プローブ化緑茶カテキン EGCG を用いたがん細胞の特異的可視化

熊添基文, 末益優美, 谷本陽祐, 弘津圭祐, 田中浩士, 高橋孝志, 山田 耕路, 立花 宏文

日本農芸化学会  2013.3 

食品因子感知システムに基づいた食品の機能性評価 Invited

立花 宏文

日本農芸化学会  2013.3 

組織内微小領域における機能性食品因子の時空間分解可視化 Invited

藤村 由紀, 三浦 大典, 割石 博之, 立花 宏文

日本農芸化学会  2013.3 

緑茶カテキン感知レセプターを介したEGCGの機能性発現機序

立花 宏文

日本茶インストラクター協会講習会  2013.3 

緑茶カテキン感知レセプターを介したEGCGの機能性発現機序

Hirofumi Tachibana

茶学術研究会  2013.3 

緑茶成分の免疫調節作用とそのしくみ

Hirofumi Tachibana

茶学術研究会シンポジウム  2013.1 

Green tea polyphenol EGCG sensing for cancer prevention Invited

立花 宏文

The 6th International Niigata symposium on Diet and Health  2012.10 

緑茶カテキンの機能性発現とレドックス Invited

立花 宏文

日本学術振興会レドックス・ライフイノベーション第１７０委員会  2012.8 

機能性食品因子を感知するしくみ Invited

立花 宏文

日本栄養・食糧学会九州沖縄支部  2012.7 

がん予防食品因子を感知する分子的基盤 Invited

立花 宏文

日本がん予防学会  2012.6 

フードファクターセンシング：機能性食品因子の生体感知システム Invited

立花宏文

日本農芸化学会大会  2012.3 

Anti-allergic action of O-methylated EGCG in green tea cv. Benifuuki International conference

Mari Maeda-Yamamoto, and Hirofumi Tachibana

International Conference on Food Factors 2011 (ICoFF2011)  2011.11 

Green tea polyphenol EGCG sensing Invited

Tachibana, H.

International Conference on Food Factors 2011 (ICoFF2011)  2011.11 

Intake of green tea extract modulates heme oxygenase-1 gene expression and Nrf2 protein expression in peripheral blood lymphocytes from human with mild hypercholesterolemia; The Kakegawa Study

Yoon Hee Kim, Shuntaro Tsukamoto, Shuya Yamashita, Koji Yamada, Hirohito Metoki, Taku Obara, Masayuki Yamamoto2, Yoichi Sameshima3, Mari Maeda-Yamamoto4, Shinichi Kuriyama2, and Hirofumi Tachibana

International Conference on Food Factors 2011 (ICoFF2011)  2011.11 

Apoptotic cell death pathway induced by green tea polyphenol EGCG through the polyphenol sensing molecule 67-kDa laminin receptor

Shuntaro Tsukamoto, Motofumi Kumazoe, Takafumi Suda, Yukari Tsurudome, Takashi Suzuki, Yuhui Huang, Koji Yamada, and Hirofumi Tachibana

International Conference on Food Factors 2011 (ICoFF2011)  2011.11 

Identification of A Gene Mediating the ER-Independent Effect of Equol on Cancer Cell Growth

Shuya Yamashita, Shoko Kamachi, Koji Yamada, and Hirofumi Tachibana

International Conference on Food Factors 2011 (ICoFF2011)  2011.11 

Factors underlying sensitivity of cancers to green tea polyphenol EGCG Invited

Tachibana, H.

2011 Annual Conference on Nutraceuticals, Functional Foods and Dietary Supplements  2011.11 

食品の免疫調節作用とそのしくみ Invited

立花宏文

(社)鹿児島県工業倶楽部法人設立２０周年記念事業シンポジウム  2011.10 

トコトリエノール感知関連遺伝子Hic2発現に対する食餌の影響

立花宏文, 隅田崇文、中原加奈美、上田直樹、宮元彩希、山下修矢、鈴木貴視、山田耕路

日本トコトリエノール研究会  2011.10 

10t,12c-CLA のがん細胞増殖抑制作用を担う遺伝子p38IPの機能解析

阿比留晶子、園田知代、山田耕路,立花宏文

第2回機能性油脂懇話会  2011.10 

Molecular basis for anti-allergic and anti-inflammatory actions of green tea polyphenols International conference

Tachibana, H.

Konkuk University Seminar  2011.9 

Molecular basis for anti-allergic and anti-inflammatory actions of green tea polyphenols Invited International conference

Tachibana, H.

Workshop on Fuctional Foods  2011.9 

Food Factor Sensing:機能性食品因子を感知するしくみ

立花宏文

日本農芸化学会西日本支部、中四国支部合同大会  2011.9 

高脂肪高ショ糖食摂取マウスにおける緑茶抽出パウダーの摂食効果

鈴木貴視、萩原立春、鶴留ゆかり、篠田有希、山口航、豊田唯、山本（前田）万里、山田耕路、立花宏文

生物機能研究会  2011.7 

緑茶カテキン感知システムに基づくEGCGのがん予防機能増強法 Invited

立花宏文

日本がん予防学会  2011.6 

Nutraceutical evaluation of diverse green tea cultivars on the basis of metabolic profiling International conference

Yoshinori Fujimura, Kana Kurihara, Megumi Ida, Reia Kosaka, Daisuke Miura, Hiroyuki Wariishi, Mari Maeda-Yamamoto, Atsushi Nesumi, Takeshi Saito, Tomomasa Kanda, Koji Yamada, and Hirofumi Tachibana

第59回米国質量分析学会（ASMS）  2011.6 

機能性食品の創製と炎症の制御

立花宏文

日本栄養・食糧学会大会  2011.5 

食品成分の免疫調節作用とその分子基盤 Invited

立花宏文

日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会  2009.10 

緑茶カテキンの標的分子研究からみえてきたこと

立花宏文

日本農芸化学会  2009.3 

緑茶カテキン受容体の発見とその作用機序 Invited

立花宏文

平成20年度農研機構シンポジウム  2008.11 

抗アレルギー食品成分の標的としての脂質ラフト Invited

立花宏文

日本食品免疫学会  2008.10 

分子標的抗がん剤としての緑茶カテキンEGCG Invited

立花宏文

日本カテキン学会  2008.8 

スフィンゴシンキナーゼ阻害による緑茶カテキンEGCGのがん特異的アポトーシス誘導活性の増強 黄宇慧、塚本俊太郎、山田脩平、熊添基文、山田耕路、立花宏文 Invited

黄宇慧, 塚本俊太郎, 山田脩平, 熊添基文, Hirofumi Tachibana

第68回日本栄養・食糧学会  2014.5 

Green Tea Extract Suppresses Disuse Muscle Atrophy in Mice International conference

Hirofumi Tachibana, Motoki Murata, Reia Kosaka, Kana Kurihara, Atsushi Nesumi, Mari Maeda-Yamamoto, Koji Yamada

20TH INTERNATIONAL CONGRESS OF NUTRITION. GRANADA 2013  2013.9 

Synthesis of a fluorescent labeled EGCG as a cancer tracer International conference

Hiroshi Tanaka, Motofumi Kumazoe, Yosuke Tanimoto, Yumi Suemasu, Yuhui Huang, Koji Yamada, Hirofumi Tachibana, Takashi Takahashi

20TH INTERNATIONAL CONGRESS OF NUTRITION. GRANADA 2013  2013.9 

緑茶カテキン感知力の分子的基盤とその疫学的検証 Invited

Hirofumi Tachibana

第68回日本栄養・食糧学会  2014.5 

茶葉カテキンによるlipid raftの解裂とアレルギー疾患の改善 Invited

立花宏文

日本小児東洋医学会  2008.4 

緑茶カテキン受容体67LRを介したEGCGのシグナル伝達機構 Invited

立花宏文

日本栄養・食糧学会大会  2007.5 

緑茶カテキン受容体 67LRを介したカテキン類の機能性発現とその結合様式 Invited

立花宏文

日本カテキン学会  2007.8 

Molecular basis for inhibition of IgE production by tea polyphenol strictinin International conference

Hirofumi Tachibana, Yoshinori Fujimura, Yu Ninomiya, Yusuke Hasegawa, Kazuko Nakayama, Koji Yamada

国際O-CHA学術会議  2007.11 

Green tea polyphenol EGCG signaling through the 67kDa laminin receptor Invited International conference

Hirofumi Tachibana

3rd International Conference on Polyphenols and Health(ICPH2007)  2007.11 

Identification of EGCG binding site in the green tea polyphenol receptor 67LR International conference

Hirofumi Tachibana, Yoshinori Fujimura, Naoto Ogawa, Mami Sumida, Sayuri Tsuruda,and Koji Yamada

International Conference on Food Factors for Health Promotion (ICOFF2007)  2007.11 

緑茶カテキン受容体67LRを介したカテキンの機能性発現機構 Invited

立花宏文

日本薬理学会  2008.3 

カテキンシグナリング：緑茶カテキン受容体を介した機能性発現機構 Invited

立花宏文

日本農芸化学会大会  2008.3 

糖転移ヘスペリジンは緑茶カテキンの作用を増強する

熊添基文、田中愛健、吉富廉、山本真生、恩田弘明、藤村由紀、立花宏文

日本農芸化学会2025年度大会  2025.3  日本農芸化学会

植物miRNA csn-miR166c-3p高含有緑茶はパーキンソン病モデルマウスにおける症状を改善し神経細胞を保護する

島田優、熊添基文、恩田弘明、小川史代、藤村由紀、立花宏文

日本農芸化学会2025年度大会  2025.3  日本農芸化学会

ヒトにおける緑茶摂取がDNAメチル化に与える影響

廣井舜、熊添基文 、藤村由紀、立花宏文

第29回日本フードファクター学会学術集会  2024.12  日本フードファクター学会

緑茶成分ストリクチニンのmiR-191-5pを介した認知機能調節作用

森元文香、岸洸聖、高木基光、松井優樹、麻生菜帆、李寛雨、熊添基文、藤村由紀、立花宏文

第29回日本フードファクター学会学術集会  2024.12  日本フードファクター学会

プロシアニジンC1によるマイクロRNAを介した骨格筋の分化促進作用

右橋陸、梅本紗希、丸亀裕貴、李寛雨、熊添基文、藤村由紀、立花宏文

第29回日本フードファクター学会学術集会  2024.12  日本フードファクター学会

ポリフェノールの機能性発現おける緑茶カテキンレセプターの役割 Invited

立花宏文

日本カテキン学会設立20周年記念講演会  2024.12  日本カテキン学会

マイクロRNAを活用した食品素材の健康機能性の評価 Invited

立花宏文

食品ニューテクノロジー研究会  2024.12  食品ニューテクノロジー研究会

緑茶成分EGCGのDNAメチル化制御作用の包括的解析

張翼麟、熊添基文、藤村由紀、立花宏文

2024年度日本栄養・食糧学会九州・沖縄支部大会  2024.10  日本栄養・食糧学会九州・沖縄支部

品種や茶期の異なる緑茶の抗糖尿病成分プロファイリング

千葉涼太郎、一瀬智美、渡邉喬嗣、熊添基文、藤村由紀、立花宏文

2024年度日本栄養・食糧学会九州・沖縄支部大会  2024.10  日本栄養・食糧学会九州・沖縄支部

食品機能とマイクロRNA Invited

立花宏文

日本農芸化学会中部支部農芸化学会創立100周年・中部支部創立70周年記念例会  2024.9  日本農芸化学会中部支部

緑茶カテキンEGCGの抗がん作用をフラバノノールFustinが増強する

磯貝航，熊添基文, 藤村由紀, 立花宏文

2024年度日本農芸化学会西日本支部大会  2024.9  日本農芸化学会西日本支部

植物miRNA csn-miR166c-3pのパーキンソン病緩和作用

島田優，熊添基文，恩田弘明，小川史代，藤村由紀，立花宏文

2024年度日本農芸化学会西日本支部大会  2024.9  日本農芸化学会西日本支部

緑茶の抗糖尿病成分探索に向けたメタボリック・プロファイリング解析

後藤瑞葵、渡邉喬嗣、一瀬智美、熊添基文、藤村由紀、立花宏文

日本ポリフェノール学会第17回学術集会  2024.8  日本ポリフェノール学会

プロシアニジンC1の筋分化促進作用におけるマイクロRNAの関与

右橋陸、梅本紗希、丸亀裕貴、李寛雨、熊添基文、藤村由紀、立花宏文

日本ポリフェノール学会第17回学術集会  2024.8  日本ポリフェノール学会

フラバノノールFustinは緑茶カテキンEpigallocatechin-3-O-gallate の抗がん作用を増強する

磯貝航、熊添基文、藤村由紀、立花宏文

日本ポリフェノール学会第17回学術集会  2024.8  日本ポリフェノール学会

ヒトにおいて緑茶摂取により発現変動する緑茶由来miRNAの解析

渡邉楓、渡邉凌矢、山本真生、熊添基文、藤村由紀、立花宏文

第60回化学関連支部合同九州大会  2024.6  日本農芸化学会西日本支部

緑茶摂取により変動したマイクロRNAによるマウスの認知機能調節作用

岸洸聖、高木基光、松井優樹、麻生菜帆、李寛雨、熊添基文、藤村由紀、立花宏文

第60回化学関連支部合同九州大会  2024.6  日本農芸化学会西日本支部

プロシアニジンC1によるマイクロRNA miR-181a-5pを介した骨格筋の機能調節作用

右橋陸、丸亀裕貴、李寛雨、梅本紗希、熊添基文、藤村由紀、立花宏文

第60回化学関連支部合同九州大会  2024.6  日本農芸化学会西日本支部

緑茶カテキンEGCGの急性肺障害抑制作用における67LRの関与

高木啓吾、小原井春香、西岡成汰、畠山結、熊添基文、藤村由紀、立花宏文

第60回化学関連支部合同九州大会  2024.6  日本農芸化学会西日本支部

体調関連バイオマーカー探索に向けた軽度不調とmiRNAの関係性解析

後藤瑞葵、千葉涼太郎、山本真生、一瀬智美、西平順、山本(前田)万里、熊添基文、藤村由紀、立花宏文

第60回化学関連支部合同九州大会  2024.6  日本農芸化学会西日本支部

ペンタガロイルグルコースのマイクロRNA miR191-5pを介した脳機能調節作用

岸洸聖、李寛雨、麻生菜帆、松井優樹、高木基光、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

緑茶カテキンEGCGの骨髄性細胞67LRを介した肝線維化抑制作用

後藤芽衣、麻生菜帆、小原井春香、山本真生、丸亀裕貴、熊添基文、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

プロシアニジンC1のマイクロRNA miR-181a-5pを介した骨格筋機能調節作用

右橋陸、丸亀裕貴、梅本紗希、熊添基文、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

緑茶カテキンEGCGの急性肺障害抑制作用における67LRの関与

高木啓吾、小原井春香、西岡成汰、畠山結、熊添基文、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

緑茶摂取後のヒト血液中における食品由来マイクロRNAの解析

渡邉楓, 渡邉凌矢, 山本真生, 熊添基文, 藤村由紀, 立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

緑茶由来植物マイクロRNA　csn-miR166c-3pのパーキンソン病緩和作用

島田優、熊添基文、恩田弘明、小川史代、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

緑茶カテキン代謝物EGC-M5による免疫チェックポイント阻害剤の抗腫瘍効果増強作用

仲嶋美里, 川本礼乃, 冨岡玲乃, 田中裕子, 熊添基文, 藤村由紀, 立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

抹茶の新たな機能性食品因子としてのマイクロRNAの抽出法の検証

黄苡嵐、一瀬智美、渡邉凌矢、辰己由華、一谷正己、衣笠仁、瀧原孝宣、熊添基文、立花宏文、藤村由紀

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

プロシアニジンC1のマイクロRNAmiR-181-5pを介した脳機能調節作用

千葉涼太郎、梅本紗希、李寛雨、熊添基文、藤村由紀、立花宏文

第78回日本栄養・食糧学会大会  2024.5  (公社)日本栄養・食糧学会

ケルセチンのがん抑制性マイクロRNA発現調節作用

@村田希,#丸亀裕貴,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

食品機能研究の今後の展望

@立花宏文

日本農芸化学会2024年度大会 シンポジウム食品機能学の40年と想定もしていなかった最前線の知見  2024.3 

食品機能実行因子としてのmiRNA

@熊添基文,@立花宏文

日本農芸化学会2024年度大会  2024.3 

抹茶の新たな機能性食品因子の探索に向けたマイクロRNA解析

#黄苡嵐,@一瀬智美,#渡邉凌矢,@辰己由華,@一谷正己,@衣笠仁,@春尾守一,@熊添基文,@立花宏文,@藤村由紀

日本農芸化学会2024年度大会  2024.3 

肝線維化が誘導される肝臓特異的67-kDa laminin receptorノックアウトマウスのメタボローム解析

@一瀬智美,#米山拓良,@竹下菜津子,@錦戸里紗,@熊添基文,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

植物マイクロRNA csn-miR166c-3p はオートファジー活性化を介してパーキンソン病症状を緩和する

#島田優,@熊添基文,@恩田弘明,@小川史代,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

緑茶カテキンEGCGがヒト末梢血由来単核細胞のDNAメチル化に与える影響

#張翼麟,#山本真生,@熊添基文,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

肝臓67kDaラミニン受容体を介したEGCGの脳機能調節作用

#麻生菜帆,#李寛雨,@熊添基文,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

ペンタガロイルグルコースはmiR-191-5pを介して脳機能調節作用を発揮する

#李 寛雨,#松井優樹,#麻生菜帆,#高木基光,#岸洸聖,@熊添基文,@藤村由紀,@立花宏文

日本農芸化学会2024年度大会  2024.3 

カカオポリフェノールの作用メカニズム

@立花宏文

第28回チョコレート・ココア国際栄養シンポジウム  2024.2 

EGCGの脳機能向上作用における肝臓67kDaラミニン受容体の関与

#麻生菜帆,#李寛雨,@熊添基文,@藤村由紀,@立花宏文

日本カテキン学会  2023.12 

Delphinidin suppresses disuse muscle atrophy and upregulates microRNA-23a-3p expression in extracellular vesicles derived from intestinal cells

@Hirofumi Tachibana,#Yuki Marugame,@Motoki Murata,@Yoshinori Fujimura

15th International Conference and Exhibition on Nutraceuticals and Functional Foods  2023.12 

Myricetin protects cognitive function accompanied with upregulation of BDNF expression

#Yu Shimada,@Yuka Sato,@Ryo Kitamura,@Motofumi Kumazoe,@Yoshinori Fujimura and @Hirofumi Tachibana

JAACT2023  2023.11 

ペンタガロイルグルコースの脳機能調節作用とマイクロRNAの関与

#高木基光,#李寛雨,#松井優樹,@熊添基文,@藤村由紀,@立花宏文

日本フードファクター学会大会  2023.11 

プロシアニジンC1の脳機能調節作用におけるmiRNAの関与

#梅本紗希,#李寛雨,@熊添基文,@藤村由紀,@立花宏文

日本フードファクター学会大会  2023.11 

緑茶カテキンEGCGの骨髄性細胞67LRを介したNASH抑制作用

#後藤芽衣,#麻生菜帆,@小原井春香,#山本真生,#丸亀裕貴,@熊添基文,@藤村由紀,@立花宏文

日本フードファクター学会大会  2023.11 

緑茶カテキン代謝物EGC-M5による免疫チェックポイント阻害剤増強作用のメカニズム

#仲嶋美里,@藤村由紀,@立花宏文

日本食品免疫学会大会  2023.11 

マイクロRNAを介したウーロンホモビスフラバンBの脂質代謝関連遺伝子調節作用

#丸亀裕貴,@吉富廉,@楊琳云,@藤村由紀,@立花宏文

日本栄養・食糧学会九州・沖縄支部大会  2023.10 

「マイクロRNAを介した食品の健康維持・増進効果」

@立花宏文

フードテック官民協議会セミナー  2023.9 

デルフィニジンの筋線維型変換作用とそのメカニズム

@髙橋里奈,@村田希,#丸亀裕貴,@藤村由紀,@立花宏文

日本農芸化学会中四国・西日本支部合同大会  2023.9